MATSUZAKI Yasushi 松崎靖司

Researcher Number	50209532
Other IDs
Affiliation (based on the past Project Information) *help	2006 – 2018: Tokyo Medical University, Medicine, Professor, 医学部, 教授 2009: 東京医科大学, 霞ヶ浦病院, 教授 2004 – 2005: 筑波大学, 大学院・人間総合科学研究科, 助教授 1999 – 2003: 筑波大学, 臨床医学系, 助教授 1990 – 1998: 筑波大学, 臨床医学系, 講師
Review Section/Research Field	Principal Investigator Gastroenterology / Gastroenterology Except Principal Investigator Gastroenterology / Gastroenterology / Applied health science / Embryonic/Neonatal medicine
Keywords	Principal Investigator UDCA / MS / LC-MS / GC-MS / アポトーシス / glucocorticoid receptor / IL-6 / IIA PLA_2 / ursodeoxycholic acid (UDCA) / chemoprevention … More / Hepatocellular carcinoma / QOL / Bragg-peak / 肝細胞癌 / autoimmune diseases / MHC class I / cellular immunity / GVHR / primary biliary cirrhosis / 分岐鎖アミノ酸 / マイオカイン / 慢性肝疾患 / Apoptosis / Nuclear receptor / Oxysterols / Cholesterol / Dehydroepiandrosterone / ラット / マススポクトロメトリー / ガスクロマトグラフィー / 胆汁酸 / 核内レセプター / オキシステロール / 肝癌 / コレステロール / デヒドロエピアンドロステロン / IIA PLA_2promortor / HepG2 cell / チロシンリン酸化 / IL-6receptor / IIA型PLA_2 / Iia-PLA_2 / 分子生物学 / 大腸発癌 / ウルソデオキシコール酸 / ミトコンドリア / 塩酸イリノテカン / DNAトポイソメラーゼ阻害剤 / 大腸癌発癌予防機序 / IIA PLA_2プロモータ / HepG2細胞 / group II phospholipase A_2 / aberrant crypt foci / arachidonate cascade / colon cancer / group II-PLA2 / aberrant crypt foci (ACF) / II型フォスフォリパーゼA_2 / abberant crypt foci / ursodeoxy cholic acid(UDCA) / アラキドン酸カスケード / 大腸癌 / Liver cirrhosis / Proton beam / 選択的照射 / 陽子線照射療法 / 集学的治療 / 局所制御 / 肝硬変 / 陽子線 / MHC calss II / GVHD(GVHR) / MHC classII / MHC classI / ursodeoxycholic acid / 原発性胆汁性肝硬変 / MHC class II / インターフェロン / 肝炎 / 脂質代謝 / ウイルス / 内科 / host factor / metabolic marker / interferon / liver cisshosis / hepatitis C / NO / がん / 鉄 / Ribonuleotide Reductase / SOD / 微量元素 / 一酸化窒素 / 胃粘膜細胞 / 胃がん細胞 … More Except Principal Investigator 胆汁酸 / コレステロール / 腸内細菌 / HMG-CoA reductase / 酸化ステロール / コレステロール代謝 / 代謝 / 消化器 / 肥満 / 糖尿病 / 肝細胞癌 / 肝細胞がん / 胆汁酸代謝 / 非B非C肝細胞癌 / 非アルコール性脂肪性肝炎 / Hepatocellular carcinoma / Colon cancer / Gas chromatography mass-spectrometry / Hep G2 cells / MAP kinase / Glucose-6-phosphate dehydrogenase / Dehydroepiandrosterone / 培養肝癌細胞 / 癌増殖抑制 / 内因性ステロイド / 癌増殖 / エチオコラノロン / プレグネノロン / エピアンドロステロン / HepG2細胞 / 肝癌 / 大腸癌 / ガスクロマトグラフィー・マススペクトロメトリー / MAPキナーゼ / HMG-CoA還元酵素 / グルコース6リン酸脱水素酵素 / Hep G2細胞 / デヒドロエピアンドロステロン / VLA-4 / adhesion molecule / Interferon-gamma / interleukin-l0 / cytokine / helper T cell subset / graft versus host reaction / primary biliary cirrhosis / Th2 / Thl / PBC / GVHR / CD4^+ / サイトカイン / CD4^+T細胞 / 移入細胞対宿主反応(GVHR) / 原発性胆汁性肝硬変(PBC) / Gas chromatography-mass spectrometry / Cholesterol 7alpha-hydroxylase / Bile acid / Cholesterol / Gallstone disease / ガスクロマトグラフィ-・マススペクトロメトリ- / コレステロ-ル7αーヒドロキシラ-ゼ / HMGーCoAレダクタ-ゼ / コレステロ-ル / ガスクロマトグラフィー・マススベクトロメトリー / HMG-CoA レダクターゼ / ガスクロマトケラフィー・マススペクトロメトリー / コレステロール7α-ヒドロキシラーゼ / HMG-CoAレダクターゼ / 胆石症 / 脂質代謝 / 慢性肝疾患 / 7dehydroxycholesterol / C型肝炎ウイルス / C 型肝炎ウイルス / MS / LC-MS / スクリーニング / LC-MS/MS / ステロール / 先天代謝異常 / タンデムマススペクトロメトリー / 高速液体クロマトグラフィー / 血清診断 / 生化学的診断 / ステロール代謝 / 先天異常学 / 過酸化脂質 / 慢性閉塞性肺疾患 / 酸化ストレス / 抗酸化酵素 / 運動療法 / 呼気ガス / 糞便 / 横断的研究 / 健康・疾病パラメーター / 弘前市岩木地区 / 地域住民 / 疫学調査 / アレルギー Less

Promotion of personalized medicine for lifestyle-related diseases by revealing bile acids, microbiota and cell signaling interaction
- Principal Investigator
  
  WATANABE Mitsuhiro
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Gastroenterology
- Research Institution
  Keio University
The actions of BCAA intermediates as myokines on hepatic metabolismPrincipal Investigator
- Principal Investigator
  
  Matsuzaki Yasushi
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Gastroenterology
- Research Institution
  Tokyo Medical University
Serum lipid biomarker for the prediction of non-B, non-C liver cancer development
- Principal Investigator
  
  IKEGAMI TADASHI
- Project Period (FY)
  2013 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Gastroenterology
- Research Institution
  Tokyo Medical University
Invasive metabolic markers for evaluation of host factor on the pathological progress of hepatitis C patientsPrincipal Investigator
- Principal Investigator
  
  MATSUZAKI Yasushi
- Project Period (FY)
  2011 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Gastroenterology
- Research Institution
  Tokyo Medical University
Non-invasive measurement of serum lipid metabolism biomarkers in patients with HCV infection
- Principal Investigator
  
  IKEGAMI Tadashi
- Project Period (FY)
  2010 – 2012
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Gastroenterology
- Research Institution
  Tokyo Medical University
Screening of inherited diseases with abnormal sterol metabolism by LC-MS/MS
- Principal Investigator
  
  HONDA Akira
- Project Period (FY)
  2008 – 2010
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Embryonic/Neonatal medicine
- Research Institution
  Tokyo Medical University
The study about the relationship between exercise therapy and oxidative stress in patients with COPD
- Principal Investigator
  
  OHISHI Shuji
- Project Period (FY)
  2007 – 2009
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Applied health science
- Research Institution
  Tokyo Medical University
Relation between allergic characteristics and intestinal flora
- Principal Investigator
  
  NAKAJI Shigeyuki
- Project Period (FY)
  2006 – 2009
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  Applied health science
- Research Institution
  Hirosaki University
一酸化窒素による細胞内微量元素分布の変動が肝細胞がん増殖に与える影響に関する研究Principal Investigator
- Principal Investigator
  
  松崎靖司
- Project Period (FY)
  2005 – 2006
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  Gastroenterology
- Research Institution
  Tokyo Medical University
  University of Tsukuba
Chemoprevention of hepatocellular carcinoma by dehydroepiandrosterone and its derivativesPrincipal Investigator
- Principal Investigator
  
  MATSUZAKI Yasushi
- Project Period (FY)
  2003 – 2006
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Gastroenterology
- Research Institution
  Tokyo Medical University
  University of Tsukuba
Suppressive effect of ursodeoxycholic acid on type IIA phospholipase A2 expression in HepG2 cells.Principal Investigator
- Principal Investigator
  
  MATSUZAKI Yasushi
- Project Period (FY)
  2000 – 2002
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Gastroenterology
- Research Institution
  University of Tsukuba
Mechanism of anti-proliferation effects of dehydroepiandrosterone on colon cancer
- Principal Investigator
  
  TANAKA Naomi
- Project Period (FY)
  1998 – 2000
- Research Category
  
  Grant-in-Aid for Scientific Research (B).
- Research Field
  
  Gastroenterology
- Research Institution
  University of Tsukuba
The immunopathogenesis and the regulation of hepatic lesions in murine model of primary biliary cirrhosis.
- Principal Investigator
  
  TANAKA Naomi
- Project Period (FY)
  1996 – 1997
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Gastroenterology
- Research Institution
  University of Tsukuba
The Chemopreventive Role of Ursodeoxycholic Acid in Colon Cancer Model : Suppressive Effects on Enhanced Group II Phospholipase A2 ExpressionPrincipal Investigator
- Principal Investigator
  
  MATSUZAKI Yasushi
- Project Period (FY)
  1996 – 1997
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Gastroenterology
- Research Institution
  University of Tsukuba
Establishment of proton beam therapy for hepatocellular carcinomaPrincipal Investigator
- Principal Investigator
  
  MATSUZAKI Yasushi
- Project Period (FY)
  1994 – 1995
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  Gastroenterology
- Research Institution
  University of Tsukuba
Elucidation of pathogenesis and UDCA effect mechanisms in primary biliary cirrhosisPrincipal Investigator
- Principal Investigator
  
  MATSUZAKI Yasushi
- Project Period (FY)
  1992 – 1993
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  Gastroenterology
- Research Institution
  INSTITUTE OF CLINICAL MEDICINE, UNIVERSITY OF TSUKUBA
Cholesterol and bile acid metabolism in cholesterol gallstone disease
- Principal Investigator
  
  OSUGA Toshiaki
- Project Period (FY)
  1990 – 1992
- Research Category
  
  Grant-in-Aid for General Scientific Research (B)
- Research Field
  
  Gastroenterology
- Research Institution
  Tsukuba University

[Book] 内科疾患診療マニュアル原発性胆汁性肝硬変2005
- Author(s)
  伊藤進一, 松崎靖司
- Total Pages
  973
- Publisher
  中外医学社
- Data Source
  KAKENHI-PROJECT-15390225
[Book] 科学大辞典(第2版)編集委員, 医学/バイテク部門委員2005
- Author(s)
  松崎靖司
- Total Pages
  1831
- Publisher
  丸善株式会社
- Data Source
  KAKENHI-PROJECT-15390225
[Book] 消化器疾患診療実践ガイド肝内胆汁うっ滞2005
- Author(s)
  本多彰, 松崎靖司
- Total Pages
  1076
- Publisher
  文光堂
- Data Source
  KAKENHI-PROJECT-15390225
[Book] 今日の治療指針2005:黄疸、胆汁うっ滞2005
- Author(s)
  松崎靖司
- Total Pages
  1676
- Publisher
  医学書院
- Data Source
  KAKENHI-PROJECT-17659209
[Book] 今日の治療指針 2005:黄疸、胆汁うっ滞2005
- Author(s)
  松崎靖司
- Total Pages
  1676
- Publisher
  医学書院
- Data Source
  KAKENHI-PROJECT-15390225
[Journal Article] Simultaneous quantification of salivary hydroxybutyrates as possible markers of amino acid and fatty acid catabolic pathways by LC-ESI-MS/MS2015
- Author(s)
  Miyazaki T, Honda A, Ikegami T, Iwamoto J, Monma T, Hirayama T, Saito Y, Yamashita K, Matsuzaki Y. . . .
- Journal Title
  
  Springerplus
  
  Volume: 4 Issue: 1 Pages: 494-494
- DOI
  10.1186/s40064-015-1304-0
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-15K00849, KAKENHI-PROJECT-25460042, KAKENHI-PROJECT-25461013, KAKENHI-PROJECT-25750334
[Journal Article] Anti-gp210 and anti-centromere antibodies for the prediction of PBC patients with an incomplete biochemical response to UDCA and bezafibrate.2015
- Author(s)
  Honda A, Ikegami T, Matsuzaki Y.
- Journal Title
  
  Hepatol Res.
  
  Volume: 45 Issue: 8 Pages: 827-828
- DOI
  10.1111/hepr.12461
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25461013
[Journal Article] Small-bowel mucosal injuries in low-dose aspirin users with obscure gastrointestinal bleeding2014
- Author(s)
  Iwamoto J, Mizokami Y, Saito Y, Shimokobe K, Honda A, Ikegami T, Matsuzaki Y
- Journal Title
  
  World J Gastroenterol
  
  Volume: 20 Issue: 36 Pages: 13133-8
- DOI
  10.3748/wjg.v20.i36.13133
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25461013
[Journal Article] Increased serum oxysterol concentrations in patients with chronic hepatitis C virus infection.2014
- Author(s)
  Ikegami T, Honda A, Miyazaki T et al.
- Journal Title
  
  Biochem. Biophys. Res. Commun.
  
  Volume: 446 Issue: 3 Pages: 736-740
- DOI
  10.1016/j.bbrc.2014.01.176
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23590051, KAKENHI-PROJECT-25461013
[Journal Article] The role of taurine on skeletal muscle cell differentiation2013
- Author(s)
  Miyazaki, Y, Honda A, Ikegami T, Matsuzaki Y
- Journal Title
  
  Adv Exp Med Biol
  
  Volume: 776 Pages: 321-328
- DOI
  10.1007/978-1-4614-6093-0_29
- ISBN
  9781461460923, 9781461460930
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25461013
[Journal Article] Bile acid malabsorption deactivates pregnane X receptor in patients with Crohn's disease2013
- Author(s)
  Iwamoto J, Saito Y, Honda A, et al
- Journal Title
  
  Inflammatory bowel diseases
  
  Volume: 19 Issue: 6 Pages: 1278-1284
- DOI
  10.1097/mib.0b013e318281f423
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590747, KAKENHI-PROJECT-23590051, KAKENHI-PROJECT-24614016, KAKENHI-PROJECT-25461013
[Journal Article] Post-therapeutic needle biopsy in patients with hepatocellular carcinoma is a useful tool to evaluate response to proton irradiation2013
- Author(s)
  Saito, Y, Matsuzaki Y, Honda A, Iwamoto J, Ikegami T, Chiba T, Sugahara S, Okumura T, Ysujii H, Doy M, Tokuue K
- Journal Title
  
  Hepatol Res
  
  Volume: Epub ahead of print Issue: 4 Pages: 403-409
- DOI
  10.1111/hepr.12133
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25461013
[Journal Article] Cholesterol 25-hydroxylation activity of CYP3A2011
- Author(s)
  Honda A, Miyazaki T, Ikegami T, Iwamoto J, Maeda T, Hirayama T, Saito Y., Teramoto T, Matsuzaki Y
- Journal Title
  
  J. Lipid Res(Epub ahead of print)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20591309
[Journal Article] Cholesterol and chronic hepatitis C infection2011
- Author(s)
  Honda A, Matsuzaki Y
- Journal Title
  
  Hepatol. Res(In press)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20591309
[Journal Article] A SNP of NPC1L1 affects cholesterol absorption in Japanese.2010
- Author(s)
  Maeda T, Honda A, Ishikawa T, Kinoshita M, Mashimo Y, Takeoka Y, Yasuda D, Kusano J, Tsukamoto K, Matsuzaki Y, Teramoto T
- Journal Title
  
  J. Atheroscler. Thromb 17
  
  Pages: 356-360
- NAID
  130004444429
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20591309
[Journal Article] Highly sensitive and specific analysis of sterol profiles in biological samples by HPLC-ESI-MS/MS.2010
- Author(s)
  Honda A, Miyazaki T, Ikegami T, Iwamoto J, Yamashita K, Numazawa M, Matsuzaki Y
- Journal Title
  
  J. Steroid Biochem. Mol. Biol 121
  
  Pages: 556-564
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20591309
[Journal Article] Highly-sensitive quantification of serum malonate, a possible marker for de novo lipogenesis, by LC-ESI-MS/MS2009
- Author(s)
  Honda A, Yamashita K, Ikegami T, Hara T, Miyazaki T, Hirayama T, Numazawa M, Matsuzaki Y
- Journal Title
  
  J. Lipid Res. 50
  
  Pages: 2124-2130
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20591309
[Journal Article] Highly sensitive quantification of key regulatory oxysterols in biological samples by LC-ESI-MS/MS2009
- Author(s)
  Honda A, Yamashita K, Hara T, Ikegami T, Miyazaki T, Shirai M, Xu G, Numazawa M, Matsuzaki Y
- Journal Title
  
  J. Lipid Res 50
  
  Pages: 350-357
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20591309
[Journal Article] Highly sensitive analysis of sterol profiles in human serum by LC-ESI-MS/MS.2008
- Author(s)
  Honda A, Yamashita K, Miyazaki H, Shirai M, Ikegami T, Xu G, Numazawa M, Hara T, Matsuzaki Y
- Journal Title
  
  J. Lipid Res 49
  
  Pages: 2063-2073
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20591309
[Journal Article] Determination of key intermediates in cholesterol and bile acid biosynthesis by stable isotope dilution mass spectrometry.2008
- Author(s)
  Yoshida T, Honda A, Miyazaki H, Matsuzaki Y
- Journal Title
  
  Anal. Chem. Insights 3
  
  Pages: 45-60
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20591309
[Journal Article] Dehydroepiandrosterone and its derivatives : potentially novel anti-proliferative and chemopreventive agents.2006
- Author(s)
  Matsuzaki Y et al.
- Journal Title
  
  Curr.Pharm.Des. 12
  
  Pages: 3411-3421
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15390225
[Journal Article] Dehydroepiandrosterone and its derivatives : potentially novel anti-proliferative and chemopreventive agents2006
- Author(s)
  Matsuzaki Y et al.
- Journal Title
  
  Current Pharmaceutical Design 12
  
  Pages: 3411-3421
- Data Source
  KAKENHI-PROJECT-15390225
[Journal Article] Dehydroepiandrosterone and its derivatives : potentially novel anti-proliferative and chemopreventive agents2006
- Author(s)
  Matsuzaki Y et al.
- Journal Title
  
  Curr Pharm Des 12
  
  Pages: 3411-3421
- Data Source
  KAKENHI-PROJECT-17659209
[Journal Article] Dehydroepiandrosterone and its derivatives : potentially novel anti-proliferative and chemopreventive agents.2006
- Author(s)
  Matsuzaki Y et al.
- Journal Title
  
  Curr. Pharm. Des. 12
  
  Pages: 3411-3421
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15390225
[Journal Article] Alcohol abuse and occult HBV-a risk factor for hepatocellular carcinoma2005
- Author(s)
  Matsuzaki Y et al.
- Journal Title
  
  Hepatol.Res. 32
  
  Pages: 67-70
- NAID
  10016478272
- Data Source
  KAKENHI-PROJECT-17659209
[Journal Article] Suppressive effect of ursodeoxycholic acid on type IIA phospholipase A2 expression in HepG2 cells2005
- Author(s)
  Ikegami T, Matsuzaki Y, et al.
- Journal Title
  
  Hepatology 41
  
  Pages: 896-905
- Data Source
  KAKENHI-PROJECT-17659209
[Journal Article] Suppressive effect of ursodeoxycholic acid on type IIA phospholipase A2 expression in HepG2 cells2005
- Author(s)
  Ikegami T, Matsuzaki Y, et al.
- Journal Title
  
  Hepatology 41
  
  Pages: 896-905
- Data Source
  KAKENHI-PROJECT-15390225
[Journal Article] Rapid inhibition of MAPK signaling and anti-proliferation effect via JAK/STAT signaling by interferon-alpha in hepatocellular carcinoma cell lines2005
- Author(s)
  Inamura K, Matsuzaki Y, et al.
- Journal Title
  
  Biochim Biophys Acta 1745(3)
  
  Pages: 401-410
- Data Source
  KAKENHI-PROJECT-15390225
[Journal Article] Alcohol abuse and occult HBV-a risk factor for hepatocellular carcinoma2005
- Author(s)
  Matsuzaki Y et al.
- Journal Title
  
  Hepatol.Res. 32
  
  Pages: 67-70
- NAID
  10016478272
- Data Source
  KAKENHI-PROJECT-15390225
[Journal Article] Rebamipide significantly inhibits indomethacin-induced mitochondrial damage, lipid peroxidation, and apoptosis in gastric epithelial RGM-1 cells.2005
- Author(s)
  Nagano Y, Matsui H, Muramatsu M, Shimokawa O, Shibahara T, Yanaka A, Nakahara A, Matsuzaki Y, Tanaka N, Nakamura Y.
- Journal Title
  
  Dig Dis Sci. 50・suppl
- Data Source
  KAKENHI-PROJECT-17659209
[Journal Article] Disrupted coordinate regulation of farnesoid X receptor (FXR) target genes in a patient with cerebrotendinous xanthomatosis2005
- Author(s)
  Honda A, Salen G, Matsuzaki Y et al.
- Journal Title
  
  J.Lipid Res. 46
  
  Pages: 287-296
- Data Source
  KAKENHI-PROJECT-17659209
[Journal Article] Disrupted coordinate regulation of farnesoid X receptor (FXR) target genes in a patient with cerebrotendinous xanthomatosis2005
- Author(s)
  Honda A, Salen G, Matsuzaki Y et al.
- Journal Title
  
  J.Lipid Res. 46
  
  Pages: 287-296
- Data Source
  KAKENHI-PROJECT-15390225
[Journal Article] Proton beam therapy for hepatocellular carcinoma : a retrospective review of 162 patients.2005
- Author(s)
  Chiba T, tokuuye K, Matsuzaki Y, et al.
- Journal Title
  
  Clin Cancer Res 15;11(10):
  
  Pages: 799-805
- Data Source
  KAKENHI-PROJECT-15390225
[Journal Article] Simultaneous determination of dehydroepiandrosterone and its 7-oxygenated metabolites in human serum by high-resolution gas chromatography-mass spectrometry.2004
- Author(s)
  Matsuzaki Y et al.
- Journal Title
  
  Steroids 69
  
  Pages: 817-824
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15390225
[Journal Article] Simultaneous determination of dehydroepiandrosterone and its 7-oxygenated metabolites in human serum by high-resolution gas chromatography-mass spectrometry2004
- Author(s)
  Matsuzaki Y et al.
- Journal Title
  
  Steroids 69
  
  Pages: 817-824
- Data Source
  KAKENHI-PROJECT-15390225
[Journal Article] Progression of autoimmune-mediated hepatic lesions in a murine graft-versus-host reaction by neutralizing IL-102003
- Author(s)
  Unno R, Matsuzaki Y, et al.
- Journal Title
  
  Hepatol. Res 26
  
  Pages: 354-361
- NAID
  10016177304
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-12670457
[Journal Article] Origin of oxysterols in hepatic bile of patients with biliary infection.2003
- Author(s)
  Yoshida T, Matsuzaki Y, Haigh WG, et al.
- Journal Title
  
  Am.J.Gastroenterol. 98
  
  Pages: 2275-2280
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-12670457
[Journal Article] Progression of autoimmune-mediated hepatic lesions in a murine graft-versus-host reaction by neutralizing IL-102003
- Author(s)
  Unno R, Matsuzaki Y, Itoh S et al.
- Journal Title
  
  Hepatol.Res. 26
  
  Pages: 354-361
- NAID
  10016177304
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-12670457
[Journal Article] Anti-proliferative action of endogenous dehydroepiandrosterone metabolites on human cancer cell lines2003
- Author(s)
  Yoshida S, Honda A, Matsuzaki Y et al.
- Journal Title
  
  Steroids. 68
  
  Pages: 73-83
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-12670457
[Journal Article] Origin of oxysterols in hepatic bile of patients with biliary infection2003
- Author(s)
  Yoshida T, Matsuzaki Y, et al.
- Journal Title
  
  Am. J. Gastroenterol. 98
  
  Pages: 2275-2280
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-12670457
[Journal Article] Degeneration of skeletal muscle fibers in the rat administrated carbon tetrachloride : similar histological findings of the muscle in a 64-year-old patient of LC with muscle cramp.2002
- Author(s)
  Matsuzaki Y, Miyazaki T, et al.
- Journal Title
  
  Hepatol.Res. 24
  
  Pages: 368-378
- NAID
  50000713782
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-12670457
[Journal Article] Decreased taurine concentration in skeletal muscles after exercise for various durations.2002
- Author(s)
  Matsuzaki Y, Miyazaki T. et al.
- Journal Title
  
  Med.Sci.Sports Exerc. 34
  
  Pages: 793-797
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-12670457
[Journal Article] Selective inhibition of CYP27A1 and of chenodeoxycholic acid synthesis in cholestatic hamster liver.2002
- Author(s)
  Matsuzaki Y, Bouscarel B, et al.
- Journal Title
  
  Biochim.Biophys.Acta. 20;8
  
  Pages: 139-148
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-12670457
[Journal Article] Selective inhibition of CYP27A1 and of chenodeoxycholic acid synthesis in cholestatic hamster liver.2002
- Author(s)
  Matsuzaki Y, Bouscarel B, et al.
- Journal Title
  
  Biochim. Biophys. Acta. 20
  
  Pages: 139-148
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-12670457
[Journal Article] Does ursodeoxycholic acid cause lichenoid eruption?2002
- Author(s)
  Matsuzaki Y, Yoshida T, et al.
- Journal Title
  
  Gastroenterology 122
  
  Pages: 1547-1547
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-12670457
[Journal Article] Side chain hydroxylations in bile acid biosynthesis catalyzed by CYP3A are markedly up-regulated in Cyp27-/- mice but not in celebroten dinous xanthomatosis.2001
- Author(s)
  Honda A, Salen G, Matsuzaki Y et al.
- Journal Title
  
  J. Biol. Chem 276
  
  Pages: 34579-34585
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-12670457
[Journal Article] Novel murine autoimmune-mediated liver disease model induced by graft-versus-host reaction and concanavalin A2001
- Author(s)
  Unno R, Matsuzaki Y, et al.
- Journal Title
  
  J.Gastroenterol.Hepatol. 16
  
  Pages: 1149-1157
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-12670457
[Journal Article] Differences in hepatic levels of intermediates in bile acid biosynthesis between Cyp27-/- mice and CTX.2001
- Author(s)
  Honda A, Salen G, Matsuzaki Y. et al.
- Journal Title
  
  J.Lipid Res. 42
  
  Pages: 291-300
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-12670457
[Journal Article] Side chain hydroxylations in bile acid biosynthesis catalyzed by CYP3A are markedly up-regulated in Cyp27-/- mice but not in celebrotendinous xanthomatosis2001
- Author(s)
  Honda A, Salen G, Matsuzaki Y, et al.
- Journal Title
  
  J.Biol.Chem. 276
  
  Pages: 34579-34585
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-12670457
[Journal Article] Novel murine autoimmune-mediated liver disease model induced by graft-versus-host reaction and concanavalin A.2001
- Author(s)
  Unno R, Matsuzaki Y, et al.
- Journal Title
  
  J. Gastroenterol. Hepatol 16
  
  Pages: 1149-1157
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-12670457
[Journal Article] Cytokine profile of liver-infiltrating CD4+T cells separated from murine primary biriary chirrhosis-like hepatic lesions induced by graft-versus-host reaction.2000
- Author(s)
  Itoh S, Matsuzaki Y, et al.
- Journal Title
  
  J.Gastroenterol.Hepatol. 15
  
  Pages: 443-451
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-12670457
[Journal Article] Regulation of 25- and 27-hydroxylation side chain cleavage pathway for cholic acid biosynthesis in humans, rabbits, and mice : assay of enzyme activities by high-resolution gas chromatography-mass spectrometry.2000
- Author(s)
  Honda A, Salen G, Shefer S, Matsuzaki Y, et al.
- Journal Title
  
  J.Lipid Res. 41
  
  Pages: 442-451
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-12670457
[Journal Article] Suppression of hepatic lesions in a murine graft-versus-host reaction by antibodies against adhesion molecules2000
- Author(s)
  Itoh S, Matsuzaki Y, et al.
- Journal Title
  
  J.Hepatol. 32
  
  Pages: 587-595
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-12670457
[Journal Article] Alcohol abuse and Occult HBV -a risk factor for hepatocellular carcinoma (Editorial).
- Author(s)
  Matsuzaki Y et al.
- Journal Title
  
  Hepatol.Res in press
- Data Source
  KAKENHI-PROJECT-15390225
[Journal Article] Dehydroepiandrosterone and its derivatives : potentially novel antiproliferative and chemopreventive agents
- Author(s)
  Matsuzaki Y et al.
- Journal Title
  
  Curr.Pharm.Des. in press
- Data Source
  KAKENHI-PROJECT-15390225
[Presentation] Comparison of the influence of pre-exercise BCAA supplementation on serum HMB level between endurance and resistance exercises2017
- Author(s)
  Miyazaki T, Ra SG, Ishikura K, Ohmori H, Ikegami T, Matsuzaki Y, Honda A
- Organizer
  Experimental Biology 2017
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K09026
[Presentation] TGR5 activation inhibits muscular BCAA catabolism via thyroid hormone activation2016
- Author(s)
  Teruo Miyazaki, Akira Honda, Tadashi Ikegami, Yasushi Matsuzaki
- Organizer
  XXIV International Bile Acid Meeting: Bile Acids in Health and Disease
- Place of Presentation
  Düsseldorf, Germany
- Year and Date
  2016-06-17
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K09026
[Presentation] The role of N-acetyltaurine on the normalization of energy metabolism balance in the skeletal muscle after endurance exercise2016
- Author(s)
  Teruo Miyazaki, Yuho Nakamura, Kei Ebina, Takaki Mizushima, Song-Gyu Ra, Keisuke Ishikura, Yasushi Matsuzaki, Hajime Ohmori, Akira Honda.
- Organizer
  20th international taurine meeting
- Place of Presentation
  Seoul, Korea
- Year and Date
  2016-05-23
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K09026
[Presentation] Serum 3-hydroxyisobutyrate as a biomarker of muscular BCAA catabolism in liver cirrhosis patients2016
- Author(s)
  Teruo Miyazaki, Akira Honda, Tadashi Ikegami, Yasushi Matsuzaki
- Organizer
  the 25th Asian Pacific Association for the Study of the Liver (APASL 2016)
- Place of Presentation
  Shinagawa, Tokyo, Japan
- Year and Date
  2016-02-20
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K09026
[Presentation] Dysregulation of hepatic 27-hydroxycholesterol in steatohepatitis model mice with hyperglycemia2016
- Author(s)
  Yara S, Ikegami T, Honda A, Miyazaki T, Monma T, Murakami M, Konishi N, Iwamoto J, Saito Y, Matsuzaki Y
- Organizer
  The 25th Asian Pacific Association for the Study of the Liver
- Place of Presentation
  新高輪プリンスホテル
- Year and Date
  2016-02-20
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25461013
[Presentation] Characteristic Features of Serum Bile Acids Profile in Patients with Non-Alcoholic Steatohepatitis with Hepatocellular Carcinoma2015
- Author(s)
  Ikegami T, Honda A, Miyazaki T, Yara S, Matsuzaki Y
- Organizer
  AACR Special Conference : Metabolism and Cancer.
- Place of Presentation
  Bellevue, WA. USA
- Year and Date
  2015-06-07
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25461013
[Presentation] Reduction of Hepatic 27-Hydroxycholesterol in Steatohepatitis Model Mice with Insulin Resistance2015
- Author(s)
  S Yara, Ikegami T, Honda A, Miyazaki T,Murakami M, Iwamoto J, Matsuzaki Y
- Organizer
  The Liver Meeting® 2015, Annual Meeting of the American Association for the Study of Liver Diseases
- Place of Presentation
  San Francisco, CA, USA
- Year and Date
  2015-11-13
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25461013
[Presentation] Serum concentrations of 3-hydroxyisobutyrate and 3-hydroxy-3-methylbutyrate as BCAA metabolites in endurance exercise2015
- Author(s)
  Teruo Miyazaki, Keisuke Ishikura, Akira Honda, Song-Gyu Ra, Hajime Ohmori, Yasushi Matsuzaki
- Organizer
  14th International Congress on Amino Acids, Peptides and Protein
- Place of Presentation
  Vienna, Austria
- Year and Date
  2015-08-03
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K09026
[Presentation] NASHおよびNASH肝癌における血中胆汁酸分画測定とその意義2014
- Author(s)
  池上　正、本多　彰、松崎靖司
- Organizer
  第100回に本消化器病学会総会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-25461013
[Presentation] 血清ステロールマーカーからみた慢性C型肝炎の薬物代謝における性差に関する検討2014
- Author(s)
  池上　正、本多　彰、松崎靖司、宮崎照雄、国府島庸之、中牟田誠
- Organizer
  第10回消化器病における性差医学・医療研究会
- Place of Presentation
  ガーデンシティ品川
- Year and Date
  2014-07-26
- Data Source
  KAKENHI-PROJECT-25461013
[Presentation] 血清ステロールマーカーからみた慢性C型肝炎患者の薬物代謝に関する検討2014
- Author(s)
  池上　正、本多　彰、松崎靖司、宮崎照雄、国府島庸之、中牟田誠
- Organizer
  第36回胆汁酸研究会
- Place of Presentation
  東海大学校友会館
- Year and Date
  2014-11-22
- Data Source
  KAKENHI-PROJECT-25461013
[Presentation] 慢性C型肝炎患者に見られる血清コレステロール値低下のメカニズム2013
- Author(s)
  池上　正、本多　彰、松崎靖司
- Organizer
  第17回に本肝臓学会大会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-25461013
[Presentation] 肝硬変患者の骨格筋における脂肪酸β酸化活性の評価2013
- Author(s)
  宮崎照雄、本多　彰、池上　正、岩本淳一、宮本和宣、松崎靖司
- Organizer
  第49回日本肝臓学会総会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-25461013
[Presentation] クローン病における核内レセプターPregnane X receptorの活性低下と胆汁酸吸収障害の影響2013
- Author(s)
  岩本淳一, 本多　彰、松崎靖司
- Organizer
  第49回日本肝臓学会総会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-25461013
[Presentation] NAFLD患者血清における酸化ステロール上昇とその意義2012
- Author(s)
  池上正、本多彰、松崎靖司
- Organizer
  第16回日本肝臓学会大会
- Place of Presentation
  神戸
- Year and Date
  2012-10-10
- Data Source
  KAKENHI-PROJECT-22590747
[Presentation] 消化器疾患患者における血中3-ハイドロキシイソ酪酸濃度の比較2012
- Author(s)
  宮崎照雄、本多彰、松崎靖司
- Organizer
  第16回日本肝臓学会大会
- Place of Presentation
  神戸
- Year and Date
  2012-10-10
- Data Source
  KAKENHI-PROJECT-22590747
[Presentation] クローン病における低コレステロール血症の発生機序と栄養指標としての意義について2012
- Author(s)
  岩本淳一、本多彰、松崎靖司
- Organizer
  第54回日本消化器病学会大会
- Place of Presentation
  神戸
- Year and Date
  2012-10-11
- Data Source
  KAKENHI-PROJECT-22590747
[Presentation] ベザフィブラートによる原発性胆汁性肝硬変の治療効果発現メカニズムの解明2011
- Author(s)
  本多彰、中牟田誠、松崎靖司
- Organizer
  第47回日本肝臓学会総会
- Place of Presentation
  東京
- Year and Date
  2011-06-03
- Data Source
  KAKENHI-PROJECT-22590747
[Presentation] 胆汁酸合成誘導体(INT747)の脂肪肝治療への可能性.2011
- Author(s)
  宮崎照雄、本多彰、松崎靖司
- Organizer
  第15回日本肝臓学会大会
- Place of Presentation
  福岡
- Year and Date
  2011-10-21
- Data Source
  KAKENHI-PROJECT-22590747
[Presentation] 胆汁酸合成誘導体(INT747)の脂肪肝治療への可能性2011
- Author(s)
  宮崎照男、本多彰、松崎靖司
- Organizer
  第15回日本肝臓学会大会
- Place of Presentation
  福岡
- Year and Date
  2011-10-21
- Data Source
  KAKENHI-PROJECT-22590747
[Presentation] 原発性胆汁性肝硬変に対するUDCAおよびベザフィブラートによる治療効果発現メカニズムの比較2010
- Author(s)
  本多彰, 池上正, 中牟田誠, 宮崎照雄, 齋藤吉史, 平山剛, 松崎靖司
- Organizer
  第46回日本肝臓学会総会(ワークショップ)
- Place of Presentation
  山形
- Year and Date
  2010-05-27
- Data Source
  KAKENHI-PROJECT-20591309
[Presentation] Non-invasive measurement of cholesterol metabolism in patients with HCV infection by using serum marker sterols2009
- Author(s)
  Ikegami T, Honda A, Nakamuta M, Miyazaki T, Hirayama T, Saitoh Y, Matsuzaki Y.
- Organizer
  第60回米国肝臓病学会
- Place of Presentation
  Boston
- Year and Date
  2009-11-02
- Data Source
  KAKENHI-PROJECT-20591309
[Presentation] 原発性胆汁性肝硬変におけるコレステロール代謝の解析2009
- Author(s)
  本多彰,中牟田誠,松崎靖司
- Organizer
  第51回日本消化器病学会大会
- Place of Presentation
  京都
- Year and Date
  2009-10-16
- Data Source
  KAKENHI-PROJECT-20591309
[Presentation] HPLC-MS/MSを用いた先天性ステロール代謝異常症一斉診断システムの確立2009
- Author(s)
  本多彰, 宮崎照雄, 池上正, 原孝, 松崎靖司
- Organizer
  第51回日本先天代謝異常学会総会
- Place of Presentation
  東京
- Year and Date
  2009-11-07
- Data Source
  KAKENHI-PROJECT-20591309
[Presentation] コレステロール・胆汁酸代謝系に関するメタボローム解析方法の開発2008
- Author(s)
  本多彰, 池上正, 宮崎照雄, 松崎靖司
- Organizer
  第12回日本肝臓学会大会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-20591309
[Presentation] Determination of serum 3-hydroxyisobutyrate, a possible biomarker for the catabolism of branched-chain amino acids in skeletal muscles, in patients with liver cirrhosis
- Author(s)
  Miyazaki T, Honda A, Ikegami T, Matsuzaki Y
- Organizer
  Falk Symposium 195. Challenges and Management of Liver Cirrhosis
- Place of Presentation
  Freiburg, Germany
- Year and Date
  2014-10-10 – 2014-10-11
- Data Source
  KAKENHI-PROJECT-23590992
[Presentation] 生活習慣病としての慢性肝疾患における血中酸化ステロール濃度測定の意義
- Author(s)
  池上　正、本多　彰、松崎靖司
- Organizer
  第18回日本肝臓学会大会　シンポジウム
- Place of Presentation
  神戸国際会議場
- Year and Date
  2014-10-23 – 2014-10-24
- Data Source
  KAKENHI-PROJECT-25461013

1. HONDA Akira (10468639)

# of Collaborated Projects: 5 results

# of Collaborated Products: 42 results
2. IKEGAMI Tadashi (40439740)

# of Collaborated Projects: 5 results

# of Collaborated Products: 27 results
3. MIYAZAKI Teruo (60532687)

# of Collaborated Projects: 4 results

# of Collaborated Products: 18 results
4. TANAKA Naomi (60111530)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
5. SHODA Junichi (90241827)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
6. 辨野義己 (40087599)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
7. NAKAJI Shigeyuki (10192220)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. OHISHI Shuji (00322462)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. ITOH Masayuki (10419731)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. OSUGA Toshiaki (20010481)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. CHIBA Toshiya (40261797)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
12. FUHJIWARA Michio (80012722)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
13. UCHIDA Kazuhiko (90211078)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
14. WATANABE Mitsuhiro (10450842)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
15. 松井裕史 (70272200)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
16. 梅田孝 (50311535)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
17. 高橋一平 (70400132)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
18. 福田真作 (60261450)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
19. 下山克 (50312492)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
20. 横山葉子 (10617244)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
21. 滝川一 (70197226)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
22. KENJI Nemoto

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
23. 岩本淳一

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

MATSUZAKI Yasushi 松崎 靖司

Research Projects

Research Products

Co-Researchers

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

The actions of BCAA intermediates as myokines on hepatic metabolismPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Invasive metabolic markers for evaluation of host factor on the pathological progress of hepatitis C patientsPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

一酸化窒素による細胞内微量元素分布の変動が肝細胞がん増殖に与える影響に関する研究Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Chemoprevention of hepatocellular carcinoma by dehydroepiandrosterone and its derivativesPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Suppressive effect of ursodeoxycholic acid on type IIA phospholipase A2 expression in HepG2 cells.Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

The Chemopreventive Role of Ursodeoxycholic Acid in Colon Cancer Model : Suppressive Effects on Enhanced Group II Phospholipase A2 ExpressionPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

MATSUZAKI Yasushi 松崎靖司

[Book] 内科疾患診療マニュアル原発性胆汁性肝硬変2005

[Book] 消化器疾患診療実践ガイド肝内胆汁うっ滞2005