Deguchi Kimiko 出口貴美子

… Alternative Names

DEGUCHI Kimiko 出口貴美子

出口貴美子デグチキミコ

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Researcher Number	50227542
Other IDs	https://orcid.org/0000-0002-2697-6736
External Links
Affiliation (Current)	2025: 慶應義塾大学, 医学部(信濃町), 講師(非常勤)
Affiliation (based on the past Project Information) *help	2016 – 2024: 慶應義塾大学, 医学部(信濃町), 講師(非常勤) 2015: 慶應義塾大学, 医学部, 講師 2015: 慶応義塾大学, 医学部, 非常勤講師 2012 – 2015: 慶應義塾大学, 医学部, 講師(非常勤) 2011: 独立行政法人国立精神・神経医療研究センター, 神経研究所・疾病研究第二部, 研究生 … More 2010 – 2011: 独立行政法人国立精神・神経医療研究センター, 神経研究所疾病研究第二部, 研究生 2009: National Center of Neurology and Psychiatry, 神経研究所・疾病研究第二部, 研究生 2008: 国立精神・神経センター, 神経研究所疾病研究第二部, 研究生 2006 – 2007: 国立精神・神経センター, 研究生 1998: 北里大, 医学部, 助手 1997: 北里大学, 医学部, 助手 1994: 北里大学, 医学部, 助手 Less
Review Section/Research Field	Principal Investigator Embryonic/Neonatal medicine / Basic Section 52050:Embryonic medicine and pediatrics-related / Embryonic/Neonatal medicine / Pediatrics Except Principal Investigator Basic Section 09030:Childhood and nursery/pre-school education-related / Medical sociology / Human genetics / Embryonic/Neonatal medicine / Pediatrics
Keywords	Principal Investigator マウスモデル / 発達障害 / 虚血性脳障害 / モデルマウス / 認知機能障害 / 超早産児 / 認知機能 / 神経細胞移動 / 脳障害 / 虚血 … More / 治療法開発 / 後遺症 / 神経幹細胞 / 軸索変性 / APP(amyloid precursor protein) / ミクログリア / TNFα / 免疫組織化学染色 / 脳室周囲白質軟化 / 超早産 / シナプス / エレクトロポレーション / フラッシュ・タグ法 / 子宮内胎児電気穿孔法 / 行動試験 / 環境要因 / トランスクリプトーム解析 / 細胞移動 / 発達神経症 / 注意欠如多動症 / 自閉スペクトラム症 / 神経学的後遺症 / DREDDシステム / 作業記憶 / 層構造 / 大脳皮質 / 行動解析 / 微細組織構築 / 神経細胞 / 脳虚血 / 病理学 / 脳・神経 / 動物モデル / 脳神経疾患 / 神経科学 / 高次脳機能障害 / 未熟児医学 / 超低出生体重児 … More Except Principal Investigator 早期発達支援 / 神経科学 / 予防的介入 / 神経発達症 / 早産児 / オンライン / 早期支援 / 看護師 / オンライン教材 / 自閉スペクトラム症 / 保護者トレーニング / 啓発ビデオ / 事故予防 / 発症年齢 / 地域差 / 発達障害児 / 事故発生背景分析 / 保育士･幼稚園教諭意識 / 全市の事故 / 事故発生時間 / 自転車事故 / 特別支援教育 / 保育園･幼稚園児 / 子どもの事故 / 特別支援学級 / 発達障害児施設 / 救急外来 / BIS分析 / 骨折 / 交通事故 / 病院救急外来 / 発達障害児の傷害 / 幼稚園 / 保育園 / 子どもの傷害 / 発生・分化 / 遺伝学 / 脳神経疾患 / BACトランスジェニックマウス / 分子遺伝学 / 移植・再生医療 / トランスレーショナルリサーチ / 脳・神経 / 医療・福祉 / 高次脳機能障害 / 脳性麻痺 / 虚血性脳傷害 / 神経前駆細胞 / 超早産児 / 脳室周囲白質軟化症 Less

早産児に対する発達支援プログラムの開発と評価：神経発達症へのプロアクティブな介入
- Principal Investigator
  
  松崎敦子
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 09030:Childhood and nursery/pre-school education-related
- Research Institution
  Saniku Gakuin College
Evaluation of parent training using online materials: Early developmental support in a Community
- Principal Investigator
  
  Matsuzaki Atsuko
- Project Period (FY)
  2020 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 09030:Childhood and nursery/pre-school education-related
- Research Institution
  Saniku Gakuin College
Analysis of pathological mechanism of cognitive impairment and neurodevelopmental disorder observed in the new model mouse of extremely preterm infantsPrincipal Investigator
- Principal Investigator
  
  DEGUCHI Kimiko
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 52050:Embryonic medicine and pediatrics-related
- Research Institution
  Keio University
Investigation of the mechanism of ischemic brain injury in extremely preterm infantsPrincipal Investigator
- Principal Investigator
  
  Deguchi Kimiko
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Embryonic/Neonatal medicine
- Research Institution
  Keio University
The study on mechanisms, causes and prevention of childhood injuries-regional, age and diseases specificity
- Principal Investigator
  
  MATSUURA Nobuo
- Project Period (FY)
  2013 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Medical sociology
- Research Institution
  Seitoku University
Establishment and analysis of a new mouse model of ischemic brain injuries in extremely preterm infantsPrincipal Investigator
- Principal Investigator
  
  Deguchi Kimiko
- Project Period (FY)
  2012 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Embryonic/Neonatal medicine
- Research Institution
  Keio University
Molecular basis for the complex neurocristopathy PCWH and mechanisms underlying SOX10 allelic affinity
- Principal Investigator
  
  INOUE Ken
- Project Period (FY)
  2009 – 2011
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Human genetics
- Research Institution
  National Center of Neurology and Psychiatry
Pathological study of higher brain dysfunction as a neurological outcome in extremely preterm infantsPrincipal Investigator
- Principal Investigator
  
  DEGUCHI Kimiko
- Project Period (FY)
  2009 – 2011
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Embryonic/Neonatal medicine
- Research Institution
  National Center of Neurology and Psychiatry
周産期脳虚血性障害の治療法開発を目指した基礎研究:リーリン回路の神経成長促進作用
- Principal Investigator
  
  井上健
- Project Period (FY)
  2007 – 2008
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  Embryonic/Neonatal medicine
- Research Institution
  National Center of Neurology and Psychiatry
超未熟児に伴う脳障害の病態研究-神経幹細胞障害モデルと幹細胞移植治療への展望
- Principal Investigator
  
  INOUE Ken
- Project Period (FY)
  2005 – 2006
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  Pediatrics
- Research Institution
  National Center of Neurology and Psychiatry
胎児、新生児の脳室周囲白室軟化に関する分子発生病理学的研究Principal Investigator
- Principal Investigator
  
  出口貴美子
- Project Period (FY)
  1997 – 1998
- Research Category
  
  Grant-in-Aid for Encouragement of Young Scientists (A)
- Research Field
  
  Embryonic/Neonatal medicine
- Research Institution
  Kitasato University
脳室周囲白質軟化の発生に関する細胞生物学的研究Principal Investigator
- Principal Investigator
  
  出口貴美子
- Project Period (FY)
  1994
- Research Category
  
  Grant-in-Aid for Encouragement of Young Scientists (A)
- Research Field
  
  Pediatrics
- Research Institution
  Kitasato University

[Journal Article] Human neocortical development as a basis to understand mechanisms underlying neurodevelopmental disabilities in extremely preterm infants2020
- Author(s)
  Kubo Ken‐ichiro、Deguchi Kimiko
- Journal Title
  
  Journal of Obstetrics and Gynaecology Research
  
  Volume: 46 Issue: 11 Pages: 2242-2250
- DOI
  10.1111/jog.14468
- Peer Reviewed
- Data Source
  KAKENHI-PUBLICLY-19H05227, KAKENHI-PROJECT-18K07855, KAKENHI-PROJECT-18K19379
[Journal Article] Association of impaired neuronal migration with cognitive deficits in extremely preterm infants2017
- Author(s)
  K. Kubo, K. Deguchi, T. Nagai, Y. Ito, K. Yoshida, T. Endo, S. Benner, W.Shan, A.o Kitazawa, M. Aramaki, K. Ishii, M. Shin, Y. Matsunaga, K. Hayashi, M. Kakeyama, C. Tohyama, K. F. Tanaka, K. Tanaka, S. Takashima, M. Nakayama, M. Itoh, Y. Hirata, B. Antalffy, D. D. Armstrong, K.Yamada, K. Inoue, and K. Nakajima
- Journal Title
  
  JCI Insight
  
  Volume: 印刷中
- Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K09723
[Journal Article] Association of impaired neuronal migration with cognitive deficits in extremely preterm infants.2017
- Author(s)
  Kubo, K.I., Deguchi, K., Nagai, T,, Ito, Y., Yoshida, K., Endo, T., Benner, S., Shan, W., Kitazawa, A., Aramaki, M., Ishii, K., Shin, M., Matsunaga, Y., Hayashi, K., Kakeyama, M., Tohyama, C., Tanaka, K.F., Tanaka, K., Takashima, S., Nakayama, M.
- Journal Title
  
  JCI Insight.
  
  Volume: 2 Issue: 10 Pages: 88609-88609
- DOI
  10.1172/jci.insight.88609
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K19483, KAKENHI-PUBLICLY-16H01621, KAKENHI-PUBLICLY-17H06062, KAKENHI-PLANNED-25117005, KAKENHI-PROJECT-15H03123, KAKENHI-PROJECT-16H05361, KAKENHI-PROJECT-17H02220, KAKENHI-PROJECT-15J08536, KAKENHI-PROJECT-15K09723, KAKENHI-PROJECT-15K18363
[Journal Article] Epidemiological, clinical, and genetic landscapes of hypomyelinating leukodystrophies.2014
- Author(s)
  Numata Y, Gotoh L, Iwaki A, Kurosawa K, Takanashi J, Deguchi K, Yamamoto T, Osaka H, Inoue K.
- Journal Title
  
  J Neurol.
  
  Volume: 261(4) Issue: 4 Pages: 752-758
- DOI
  10.1007/s00415-014-7263-5
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24591615, KAKENHI-PROJECT-24591790, KAKENHI-PROJECT-25670485
[Journal Article] 先天性大脳白質形成不全症ーゲノム解析から診断・治療への取り組み2013
- Author(s)
  井上健、岩城明子、黒澤健司、高梨潤一、出口貴美子、山本俊至、小坂仁
- Journal Title
  
  脳と発達
  
  Volume: 45 Pages: 122-126
- NAID
  10031156273
- Data Source
  KAKENHI-PROJECT-24591615
[Journal Article] 先天性大脳白質形成不全症：ゲノム解析から診断、治療への取り組み2013
- Author(s)
  井上　健，岩城明子，黒澤健司，高梨潤一，出口貴美子，山本俊至，小坂　仁
- Journal Title
  
  脳と発達
  
  Volume: 45 Pages: 122-126
- NAID
  10031156273
- Data Source
  KAKENHI-PROJECT-24591615
[Journal Article] Effect of curcumin in a mouse model of Pelizaeus-Merzbacher disease.2012
- Author(s)
  Yu LH, Morimura T, Numata Y, Yamamoto R, Inoue N, Antalfy B, Goto Y, Deguchi K, Osaka H, Inoue K.
- Journal Title
  
  Mol Genet Metab.
  
  Volume: 106(1) Pages: 108-114
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24591615
[Journal Article] Effect of curcumin in a mouse model of Pelizaeus-Merzbacher disease2012
- Author(s)
  Yu L-H, Morimura T, Numata Y, Yamamoto R, Inoue N, Antalfy B, Goto Y, Deguchi K, Osaka H, Inoue K.
- Journal Title
  
  Mol Genet Metab
  
  Volume: 106 Issue: 1 Pages: 108-114
- DOI
  10.1016/j.ymgme.2012.02.016
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21390103, KAKENHI-PROJECT-21591425, KAKENHI-PROJECT-23659531
[Journal Article] 小坂仁先天性大脳白質形成不全症: Pelizaeus-Merzbacher病とその類縁疾患2011
- Author(s)
  井上健,岩城明子,黒澤健司,高梨潤一,出口貴美子,山本俊至, 小坂仁
- Journal Title
  
  脳と発達
  
  Volume: 43(6) Pages: 435-442
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21591425
[Journal Article] Neurological phenotype of Schimke immuno-osseous dysplasia and neurodevelopmental expression of SMARCAL12008
- Author(s)
  Deguchi K, 他
- Journal Title
  
  J Neuropath Exp Neurol 67
  
  Pages: 565-577
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19659277
[Journal Article] Spinocerebellar ataxia with axonal neuropathy: consequence of a Tdpl recessive neomorphic mutation2007
- Author(s)
  Hirano R, Interthal H, Huang C, Nakamura T, Deguchi K, 他 InoueK, 他
- Journal Title
  
  EMBO J 26
  
  Pages: 4732-4743
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19659277
[Journal Article] Periventricular leukomalacia2006
- Author(s)
  Deguchi K, Miller G
- Journal Title
  
  UpToDate (Online review series) http://www.uptodate.com
- Data Source
  KAKENHI-PROJECT-17659324
[Journal Article] Neurological phenotype of Schimke immuno-osseous dysplasia and neurodevelopmental expression of SMARCAL1
- Author(s)
  Deguchi K, Clewing JM, Elizndo LI, 他 Inoue K, 他
- Journal Title
  
  J Neuropath Exp Neurol In press
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19659277
[Journal Article] Brains of extremely premature infants with white matter injury also exhibit altered neural progenitor cells and cortical development.
- Author(s)
  Deguchi K, Takashima S, Armstrong DL, Inoue K
- Journal Title
  
  (In preparation)
- Data Source
  KAKENHI-PROJECT-17659324
[Presentation] 自閉スペクトラム症疑い児の発達的特徴～生後10ヶ月および18ヶ月時の経時的調査からわかること2024
- Author(s)
  松崎敦子・中村晃子・西田佳史・井上健・出口貴美子
- Organizer
  日本発達心理学会第35回大会
- Data Source
  KAKENHI-PROJECT-20K02705
[Presentation] Is transient hypertonia in the lower extremities in infancy an early sign of autism spectrum disorder? An on-going prospective study2023
- Author(s)
  Deguchi, K., Nakamura, A., Saito, A., Nishida, Y., Matuzaki, A., & Ken Inoue
- Organizer
  15th European Paediatric Neurology Society Congres
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K02705
[Presentation] 生後４ヶ月健診で見られる筋緊張亢進と自閉スペクトラム症の関連についての前向き研究―第１報2022
- Author(s)
  出口貴美子・井上健・中村晃子・松﨑敦子
- Organizer
  第40回日本小児心身医学会学術集会
- Data Source
  KAKENHI-PROJECT-20K02705
[Presentation] 10ヶ月児健診における発達評価：自閉スペクトラム症疑い群と定型発達群2022
- Author(s)
  松﨑敦子・出口貴美子・西田佳史
- Organizer
  第69回日本小児保健協会学術集会
- Data Source
  KAKENHI-PROJECT-20K02705
[Presentation] 発生段階における虚血等による脳傷害が脳の発達に与える影響の解析2020
- Author(s)
  久保健一郎、出口貴美子、吉永怜史、野々村美康、大島鴻太、高杉聡、北澤彩子、井上健、仲嶋一範
- Organizer
  第123回日本小児科学会学術集会
- Invited
- Data Source
  KAKENHI-PROJECT-18K07855
[Presentation] New aspects of extremely preterm infants with brain injury2019
- Author(s)
  Kimiko Deguchi, Ken-ichiro Kubo, Kazunori Nakajima, Ken Inoue
- Organizer
  The 20th Annual Meeting of Infantile Seizure Society
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K07855
[Presentation] Extremely preterm infants with brain injury leads to cognitive dysfunction due to neuronal brain network damage2019
- Author(s)
  Kimiko Deguchi, Ken-ichiro Kubo, Kazunori Nakajima, Ken Inoue
- Organizer
  15th Asian and Oceanian Congress of Child Neurology (AOCCN) & 41st Malaysian Paediatric Association Annual Congress 2019
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K07855
[Presentation] 神経細胞移動の障害が超早産児の認知機能低下に関与する可能性についての検討2019
- Author(s)
  久保　健一郎，出口　貴美子，井上　健，仲嶋　一範
- Organizer
  第24回認知神経科学会学術集会
- Invited
- Data Source
  KAKENHI-PROJECT-18K07855
[Presentation] 脳の細胞構築に注目して精神疾患の病態を理解する試みについて2019
- Author(s)
  久保　健一郎，出口　貴美子，井上　健，仲嶋　一範
- Organizer
  第115回日本精神神経学会学術総会
- Invited
- Data Source
  KAKENHI-PROJECT-18K07855
[Presentation] 超早産児虚血モデルマウスの開発と応用2019
- Author(s)
  久保　健一郎，出口　貴美子，井上　健，仲嶋　一範
- Organizer
  第4回小児ニューロリハビリテーション研究会・第4回超早産児神経発達症研究会
- Invited
- Data Source
  KAKENHI-PROJECT-18K07855
[Presentation] 超早産児脳の最近の知見 ─NICUのその後をどう育むか？─ 在胎20－28週のヒト脳の脆弱性2019
- Author(s)
  出口　貴美子、久保　健一郎、井上　健、仲嶋　一範
- Organizer
  第4回小児ニューロリハビリテーション研究会・第4回超早産児神経発達症研究会
- Invited
- Data Source
  KAKENHI-PROJECT-18K07855
[Presentation] Improvement of cognitive deficits observed in a mouse model of extremely preterm infants with brain injuries2018
- Author(s)
  Ken-ichiro Kubo, Kimiko Deguchi, Debabrata Hazra, Satoshi Yoshinaga, Ayako Kitazawa, Minkyung Shin, Keitaro Yoshida, Kenji F. Tanaka, Ken Inoue, and Kazunori Nakajima
- Organizer
  第123回日本解剖学会総会・全国学術集会
- Data Source
  KAKENHI-PROJECT-15K09723
[Presentation] 超早産児虚血性脳障害モデルマウスの解析と治療戦略2018
- Author(s)
  久保健一郎、出口貴美子、ハズラデバブラタ、吉永怜史、井上健、仲嶋一範
- Organizer
  日本新生児生育医学会・学術集会サテライトセミナー
- Invited
- Data Source
  KAKENHI-PROJECT-18K07855
[Presentation] Pathogenesis of neurodevelopmental disorders in extremely preterm infants2018
- Author(s)
  Kimiko Deguchi, Ken-ichiro Kubo, Ken Inoue, and Kazunori Nakajima
- Organizer
  11th FENS Forum of Neuroscience
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K07855
[Presentation] 神経発達症モデルマウスの作成とその神経回路の解析2018
- Author(s)
  久保健一郎、出口貴美子、石井一裕、井上健、仲嶋一範
- Organizer
  2018年度生理学研究所研究会「情動の神経回路機構とその破綻」
- Invited
- Data Source
  KAKENHI-PROJECT-18K07855
[Presentation] 超早産児における神経発達症の新たな知見と治療戦略2018
- Author(s)
  出口貴美子、久保健一郎、井上健、仲嶋一範
- Organizer
  第121回日本小児科学会学術集会
- Invited
- Data Source
  KAKENHI-PROJECT-18K07855
[Presentation] Neuronal network damage in mouse model of extremely preterm infants with brain injury2018
- Author(s)
  Kimiko Deguchi, Ken-ichiro Kubo, Ken Inoue, and Kazunori Nakajima
- Organizer
  22nd Biennial Meeting of the International Society for Developmental Neuroscience (ISDN2018)
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K07855
[Presentation] Pathophysiology of neuronal network damage in the mouse model of extremely preterm infants2018
- Author(s)
  Kimiko Deguchi, Ken-ichiro Kubo, Ken Inoue, and Kazunori Nakajima
- Organizer
  第60回日本小児神経学会学術集会
- Data Source
  KAKENHI-PROJECT-18K07855
[Presentation] Analysis of cortical development in a newly established mouse model of extremely preterm infants with brain injuries2017
- Author(s)
  Ken-ichiro Kubo, Kimiko Deguchi, et al.
- Organizer
  Society for Neuroscience, Neuroscience 2017 meeting
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K09723
[Presentation] Establishment of a mouse model of extremely preterm infants with brain injuries and analysis of neuronal migration2017
- Author(s)
  Ken-ichiro Kubo, Kimiko Deguchi, Taku Nagai, Keitaro Yoshida, Wei Shan, Ayako Kitazawa, Michihiko Aramaki, Kazuhiro Ishii, Shin Minkyung, Kenji F. Tanaka, Sachio Takashima, Masahiro Nakayama, Masayuki Itoh, Yukio Hirata, Barbara Antalffy, Dawna D. Armstrong, Kiyofumi Yamada, Ken Inoue, and Kazunori Nakajima
- Organizer
  第40回日本神経科学大会
- Data Source
  KAKENHI-PROJECT-15K09723
[Presentation] 超早産児脳障害のモデルマウス脳における組織構築の解析2017
- Author(s)
  久保健一郎、出口貴美子、北澤彩子、石井一裕、シンミンギョン、高嶋幸男、中山雅弘、伊藤雅之、井上健、仲嶋一範
- Organizer
  第122回日本解剖学会総会・全国学術集会
- Place of Presentation
  長崎大学坂本キャンパス、長崎市(長崎県)
- Year and Date
  2017-03-28
- Data Source
  KAKENHI-PROJECT-15K09723
[Presentation] Abnormal neuronal migration with ischemic brain injuries in extremely preterm infants underlies subsequent cognitive impairment2017
- Author(s)
  Kimiko Deguchi, Ken-ichiro Kubo, Kazunori Nakajima, and Ken Inoue
- Organizer
  12th European Paediatric Neurology Society (EPNS) Congress
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K09723
[Presentation] 認知機能障害を伴うマウスモデルの作成とその脳における細胞構築の解析2017
- Author(s)
  Ken-ichiro Kubo, Kimiko Deguchi, Kazuhiro Ishii, Ken Inoue, and Kazunori Nakajima
- Organizer
  第60回日本神経化学会大会
- Data Source
  KAKENHI-PROJECT-15K09723
[Presentation] マウスにおける神経発達障害モデルの作成とその解析2017
- Author(s)
  久保健一郎、出口貴美子、石井一裕、井上健、仲嶋一範
- Organizer
  第39回日本生物学的精神医学会・第47回日本神経精神薬理学会合同年会
- Invited
- Data Source
  KAKENHI-PROJECT-15K09723
[Presentation] 超早産児に生じる脳障害のマウスモデル作成の試み2017
- Author(s)
  久保健一郎、出口貴美子、永井拓、シャンウェイ、北澤彩子、荒巻道彦、石井一裕、シンミンギョン、高嶋幸男、中山雅弘、伊藤雅之、アンタルフィバーバラ、アームストロングダーナ、山田清文、井上健、仲嶋一範
- Organizer
  第52回TOKYOニューロサイエンス研究会
- Data Source
  KAKENHI-PROJECT-15K09723
[Presentation] Reelin coupled with myelin may play a role in long term maintenance of myelin2016
- Author(s)
  Kimiko Deguchi，Takao Honda, Ken-ichiro Kubo, Kazunori Nakajima,and Ken Inoue
- Organizer
  第58回日本小児神経学会学術集会
- Place of Presentation
  京王プラザホテル新宿、新宿(東京都）
- Year and Date
  2016-06-03
- Data Source
  KAKENHI-PROJECT-15K09723
[Presentation] 子どもの事故発生要因と予防ｰ地域、年齢、疾患特性の解析2016
- Author(s)
  松浦信夫、岡　敏明、原田正平、細田のぞみ、昆　伸也、峰尾恵梨、石井　　正浩、出口貴美子
- Organizer
  第119回日本小児科学会学術集会
- Place of Presentation
  ロイトン札幌（札幌市）
- Year and Date
  2016-05-13
- Data Source
  KAKENHI-PROJECT-25293120
[Presentation] Reelin coupled with myelin may play a role in long-term maintenance of myelin2016
- Author(s)
  Kimiko Deguchi, Takao Honda, Ken-ichiro Kubo, Kazunori Nakajima, and Ken Inoue
- Organizer
  21st Biennial Meeting of the International Society for Developmental Neuroscience (ISDN2016)
- Place of Presentation
  Antibes-Juan les Pins, France
- Year and Date
  2016-05-11
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K09723
[Presentation] 環境要因としての虚血ストレスが大脳皮質の発達に与える影響2016
- Author(s)
  久保健一郎、出口貴美子、井澤栄一、井上健、仲嶋一範
- Organizer
  フォーラム2016：衛生薬学・環境トキシコロジー
- Place of Presentation
  昭和大学旗の台キャンパス、品川区(東京都）
- Year and Date
  2016-09-10
- Invited
- Data Source
  KAKENHI-PROJECT-15K09723
[Presentation] 保育園･幼稚園児の傷害に関わる遊具、備品などの解析2016
- Author(s)
  松浦信夫、西田佳史、原田正平、高橋かほる、腰川一恵、昆　伸也、細田のぞみ、出口貴美子、岡　敏明、堀田文絵
- Organizer
  第6３回日本小児保健協会学術集会
- Place of Presentation
  大宮ソニックシティ（さいたま市）
- Year and Date
  2016-06-23
- Data Source
  KAKENHI-PROJECT-25293120
[Presentation] Why does cognitive impairment frequently develop later in extremely preterm infants2016
- Author(s)
  Ken-ichiro Kubo, Kimiko Deguchi, Taku Nagai, Wei Shan, Ayako Kitazawa, Michihiko Aramaki, Kazuhiro Ishii, Shin Minkyung, Sachio Takashima, Masahiro Nakayama, Masayuki Itoh, Barbara Antalffy, Dawna D. Armstrong, Kiyofumi Yamada, Ken Inoue, and Kazunori Nakajima
- Organizer
  Cell Symposia: Big Questions in Neuroscience
- Place of Presentation
  Paradise Point Resort & Spa,San Diego, California, U.S.A.
- Year and Date
  2016-11-10
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K09723
[Presentation] 子どもの事故の発生要因の解析と予防ｰ地域、年齢、疾患特性の解析2015
- Author(s)
  松浦信夫、西田佳史、原田正平、高橋かほる、腰川一恵、昆　伸也、細田のぞみ、出口貴美子、岡　敏明、堀田文絵
- Organizer
  第62回日本小児保健協会学術集会
- Place of Presentation
  長崎ブリックホール（長崎市）
- Year and Date
  2015-06-17
- Data Source
  KAKENHI-PROJECT-25293120
[Presentation] 子どもの事故の発生要因の解析と予防ｰ地域、年齢、疾患特性の解析2015
- Author(s)
  松浦信夫、西田佳史、原田正平、高橋かほる、腰川一恵、細田のぞみ、出口貴美子
- Organizer
  第21回日本保育園保健学会
- Place of Presentation
  鹿児島市民文化ホール（鹿児島市）
- Year and Date
  2015-10-17
- Data Source
  KAKENHI-PROJECT-25293120
[Presentation] Abnormal cortical architectures and neuropsychiatric disorders2014
- Author(s)
  Ken-ichiro Kubo, Kimiko Deguchi, Taku Nagai, Wei Shan, Ayako Kitazawa, Michihiko Aramaki, Kazuhiro Ishii, Kiyofumi Yamada, Ken Inoue, Kazunori Nakajima
- Organizer
  第87回日本薬理学会年会
- Place of Presentation
  東北大学百周年記念会館川内萩ホール・仙台国際センター、仙台（宮城県）
- Invited
- Data Source
  KAKENHI-PROJECT-24591615
[Presentation] Abnormal neuronal migration with ischaemic brain injuries may cause cognitive dysfunction in extremely preterm infants2013
- Author(s)
  Kimiko Deguchi, Ken-ichiro Kubo, Dawna Armstrong, Kazunori Nakajima, and Ken Inoue
- Organizer
  23nd Meeting of the European Neurological Society (ENS)
- Place of Presentation
  Convention Centre Gran Via, Barcelona, Spain
- Data Source
  KAKENHI-PROJECT-24591615
[Presentation] Preclinical studies for the treatment of Pelizaeus-Merzbacher disease with clinically applicable compounds, curumin and chloroquine.2013
- Author(s)
  Inoue K, Morimura T, Numata Y, Yu L-H, Gotoh L, Yamamoto R, Inoue N, Antalfy B, Deguchi K, Osaka H, Goto Y
- Organizer
  23nd Meeting of the European Neurological Society (ENS)
- Place of Presentation
  Convention Centre Gran Via, Barcelona, Spain
- Data Source
  KAKENHI-PROJECT-24591615
[Presentation] Epidemiological and molecular diagnostic landscape of Pelizaeus-Merzbacher disease and associated disorders in Japan: a nation-wide survey.2012
- Author(s)
  Inoue, K Numata Y, Iwaki A, Kurosawa K, Takanashi J, Deguchi K, Yamamoto T, Osaka H.
- Organizer
  22nd Meeting of the European Neurological Society
- Place of Presentation
  Prague, Czech
- Data Source
  KAKENHI-PROJECT-24591615
[Presentation] Treating Pelizaeus-Merzbacher disease with clinically applicable compounds, curumin and chloroquine: preclinical studies.2012
- Author(s)
  Ken Inoue, Toshifumi Morimura, Yurika Numata, Li-Hua Yu, Leo Gotoh, Ryoko Yamamoto, Naoko Inoue, Barbara Antalfy, Kimiko Deguchi, Hitoshi Osaka , Yu-ichi Goto
- Organizer
  62nd Annual meeting of the American Society of Human Genetics
- Place of Presentation
  San Francisco, USA
- Data Source
  KAKENHI-PROJECT-24591615
[Presentation] 先天性大脳白質形成不全症：ゲノム解析から診断、治療への取り組み2012
- Author(s)
  井上　健，岩城明子，黒澤健司，高梨潤一，出口貴美子，山本俊至，小坂　仁
- Organizer
  第54回日本小児神経学会総会
- Place of Presentation
  ロイトン札幌、札幌市
- Invited
- Data Source
  KAKENHI-PROJECT-24591615
[Presentation] 超早産児の虚血性脳傷害モデルマウスを用いた解析；第３報2012
- Author(s)
  出口貴美子、久保健一郎、仲嶋一範、井上　健
- Organizer
  第54回日本小児神経学会総会
- Place of Presentation
  ロイトン札幌、札幌市
- Data Source
  KAKENHI-PROJECT-24591615
[Presentation] Pelizaeus-Merzbacher病の治療法開発への試み2012
- Author(s)
  井上　健、守村敏史、沼田有里佳、Li-Hua Yu、後藤玲央、山本良子、井上直子、出口貴美子、小坂　仁、後藤雄一
- Organizer
  第57回日本人類遺伝学会
- Place of Presentation
  京王プラザホテル、東京
- Data Source
  KAKENHI-PROJECT-24591615
[Presentation] 新たな超早産児の虚血性脳傷害モデルマウスを用いた解析(続報)2011
- Author(s)
  出口貴美子、久保健一郎、仲島一範、井上健
- Organizer
  第53回日本小児神経学会
- Place of Presentation
  横浜、パシフィコ横浜
- Year and Date
  2011-05-28
- Data Source
  KAKENHI-PROJECT-21591425
[Presentation] A comprehensive nation-wide epidemiological survey for Pelizaeus-Merzbacher disease and associated disorders in Japan2011
- Author(s)
  Inoue K, Numata Y, Ohkubo T, Arima E, Iwaki A, Kurosawa K, Takanashi J, Deguchi K, Yamamoto T, Osaka H.
- Organizer
  12^<th> International Congress of Human Genetics
- Place of Presentation
  Montreal, Canada
- Year and Date
  2011-10-13
- Data Source
  KAKENHI-PROJECT-21390103
[Presentation] 先天性大脳白質形成不全症の診断基準と疾患分類の作成2011
- Author(s)
  井上健,岩城明子,黒澤健司,高梨潤一,出口貴美子,山本俊至,小坂仁
- Organizer
  第53回日本小児神経学会
- Place of Presentation
  横浜
- Year and Date
  2011-05-26
- Data Source
  KAKENHI-PROJECT-21390103
[Presentation] 先天性大脳白質形成不全症の統合的研究の推進2011
- Author(s)
  井上健、岩城明子、黒澤健司、高梨潤一、出口貴美子、山本俊至、小坂仁
- Organizer
  第56回日本人類遺伝学会総会
- Place of Presentation
  千葉
- Year and Date
  2011-11-12
- Data Source
  KAKENHI-PROJECT-21390103
[Presentation] Abnormal neuronal migration with ischemic brain injuries may cause cognitive dysfunction in extremely preterm infants.2010
- Author(s)
  K Deguchi, K Kubo, DL Armstrong, K Nakajima, K Inoue.
- Organizer
  18th Biennial Meeting of the International Society for Development Neuroscience
- Place of Presentation
  Estoril Convention Centre, Estoril, Portugal
- Year and Date
  2010-06-08
- Data Source
  KAKENHI-PROJECT-21591425
[Presentation] 新たな超早産児の虚血性脳障害のモデルマウスの解析:神経前駆細胞の移動障害2010
- Author(s)
  出口貴美子、久保健一郎、仲嶋一範、井上健
- Organizer
  第55回日本未熟児新生児学会
- Place of Presentation
  神戸コンベンションセンター、神戸
- Year and Date
  2010-10-10
- Data Source
  KAKENHI-PROJECT-21591425
[Presentation] Abnormal neuronal migration with ischemic brain injuries may cause cognitive dysfunction in extremely preterm infants2010
- Author(s)
  K Deguchi, K Kubo, DL Armstrong, K Nakajima, K Inoue
- Organizer
  18th Biennial Meeting of the International Society for Development Neuroscience
- Place of Presentation
  Estoril, Portugal
- Year and Date
  2010-06-08
- Data Source
  KAKENHI-PROJECT-21390103
[Presentation] Abnormal neuronal migration with ischemic brain injuries may cause cognitive dysfunction in extremely preterm infants2010
- Author(s)
  K Deguchi, K Kubo, DL Armstrong, K Nakajima, K Inoue
- Organizer
  18th Biennial Meeting of the International Society for Development Neuroscience
- Place of Presentation
  Estoril, Portugal
- Year and Date
  2010-06-08
- Data Source
  KAKENHI-PROJECT-21591425
[Presentation] 周産期脳障害による高次脳機能障害のマウスモデルの開発2010
- Author(s)
  出口貴美子、久保健一郎、仲嶋一範、井上健
- Organizer
  第52回日本小児神経学会総会
- Place of Presentation
  福岡国際会議場、福岡
- Data Source
  KAKENHI-PROJECT-21591425
[Presentation] Abnormal neuronal migration with ischemic brain injuries may cause cognitive dysfunction in extremely preterm infants2010
- Author(s)
  Deguchi K, Kubo K, Armstrong DL, Nakajima K, Inoue K
- Organizer
  18th Biennial Meeting of the International Society for Development Neuroscience
- Place of Presentation
  Estoril Convention Centre, Estoril, Portugal
- Year and Date
  2010-06-08
- Data Source
  KAKENHI-PROJECT-21390103
[Presentation] Curcumin partially mitigated the phenotype of Pelizaeus-Merzbacher disease caused by PLP1 point mutations in mouse2009
- Author(s)
  K. Inoue, L-H. Yu, T. Morimura, H. Iwashita, R. Yamamoto, K. Deguchi, B. Antalfy, N. Inoue, H. Osaka, M. Itoh, Y. Goto
- Organizer
  59^<th> Annual meeting of the American Society of Human Genetics
- Place of Presentation
  Honolulu, HI
- Year and Date
  2009-10-23
- Data Source
  KAKENHI-PROJECT-21390103
[Presentation] A neuronal migration regulator Reelin pathway may be involved in the white matter pathology in Alzheimer's disease2008
- Author(s)
  Deguchi K, 他
- Organizer
  18^<th> Meeting of European Neurological Society
- Place of Presentation
  フランス・ニース
- Year and Date
  2008-06-10
- Data Source
  KAKENHI-PROJECT-19659277
[Presentation] Extremely preterm infants with white matter lnjury:impaired neural progenitor cells and cortical development2007
- Author(s)
  出口貴美子
- Organizer
  第35回日本胎児新生児神経研究会
- Place of Presentation
  大阪
- Year and Date
  2007-05-20
- Data Source
  KAKENHI-PROJECT-19659277
[Presentation] 子どもの事故の発生要因の解析と予防－地域、年齢、疾患特性の解析－
- Author(s)
  松浦信夫、西田佳史、原田正平、高橋かほる、腰川一恵、出口貴美子、細田のぞみ
- Organizer
  第62会日本小児保健学会
- Place of Presentation
  長崎市
- Year and Date
  2015-06-18 – 2015-06-20
- Data Source
  KAKENHI-PROJECT-25293120
[Presentation] Abnormal neuronal migration with ischemic brain injury in extremely preterm infants underlies subsequent cognitive impairment
- Author(s)
  Kimiko Deguchi, Ken-ichiro Kubo, Kazunori Nakajima, and Ken Inoue
- Organizer
  Joint Meeting of the 20th Biennial Meeting of the International Society for Developmental Neuroscience (ISDN) and the 5th Annual NeuroDevNet Brain Development Conference
- Place of Presentation
  Hilton Montreal Bonaventure, Montreal, Canada
- Year and Date
  2014-07-19 – 2014-07-24
- Data Source
  KAKENHI-PROJECT-24591615
[Presentation] Analyses of the effects of embryonic ischemia on brain development (胎児期の虚血が脳の構造と機能に及ぼす影響)
- Author(s)
  Ken-ichiro Kubo, Kimiko Deguchi, Taku Nagai, Michihiko Aramaki, Kiyofumi Yamada, Ken Inoe, Kazunori Nakajima
- Organizer
  第92回日本生理学会大会第120回日本解剖学会総会・全国学術集会合同大会
- Place of Presentation
  神戸国際会議場・展示場、神戸（兵庫県）
- Year and Date
  2015-03-21 – 2015-03-23
- Invited
- Data Source
  KAKENHI-PROJECT-24591615
[Presentation] 超早産児の高次脳機能障害に結びつくメカニズムの解明；虚血性脳傷害モデルマウスを用いた解析【第4報】
- Author(s)
  出口貴美子、久保健一郎、永井拓、Shan Wei、山田清文、仲嶋一範、井上健
- Organizer
  第56回日本小児神経学会学術集会
- Place of Presentation
  アクトシティ浜松、浜松（静岡県）
- Year and Date
  2014-05-29 – 2014-05-31
- Data Source
  KAKENHI-PROJECT-24591615
[Presentation] Abnormal brain cytoarchitecture as one of the micro-endophenotypes of neuropsychiatric disorders (精神疾患のマイクロエンドフェノタイプとしての微細な脳組織構築の異常)
- Author(s)
  Ken-ichiro Kubo, Kazuhiro Ishii, Toshihiro Endo, Seico Benner, Taku Nagai, Wei Shan, Kimiko Deguchi, Ken Inoue, Kiyofumi Yamada, Chiharu Tohyama, Masaki Kakeyama, and Kazunori Nakajima
- Organizer
  第36回日本生物学的精神医学会・第57回日本神経化学会大会
- Place of Presentation
  奈良県文化会館・奈良県新公会堂、奈良（奈良県）
- Year and Date
  2014-09-29 – 2014-10-01
- Invited
- Data Source
  KAKENHI-PROJECT-24591615

1. INOUE Ken (30392418)

# of Collaborated Projects: 6 results

# of Collaborated Products: 44 results
2. KUBO Kenichirou (20348791)

# of Collaborated Projects: 4 results

# of Collaborated Products: 39 results
3. NISHIDA Yoshifumi (60357712)

# of Collaborated Projects: 2 results

# of Collaborated Products: 7 results
4. Matsuzaki Atsuko (40792297)

# of Collaborated Projects: 2 results

# of Collaborated Products: 1 results
5. INOUE Takayoshi (20370984)

# of Collaborated Projects: 1 results

# of Collaborated Products: 7 results
6. MATSUURA Nobuo (50002332)

# of Collaborated Projects: 1 results

# of Collaborated Products: 5 results
7. HARADA Syouhei (70392503)

# of Collaborated Projects: 1 results

# of Collaborated Products: 5 results
8. TAKAHASHI Kaoru (40532784)

# of Collaborated Projects: 1 results

# of Collaborated Products: 4 results
9. KOSHIKAWA Kazue (70406742)

# of Collaborated Projects: 1 results

# of Collaborated Products: 4 results
10. KON Shinya (70458800)

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
11. HOSODA Nozomi (80199504)

# of Collaborated Projects: 1 results

# of Collaborated Products: 5 results
12. 高嶋幸男 (70038743)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
13. 峰尾恵梨 (90566944)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
14. 本田崇 (50525532)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
15. 岡橋彩 (70866813)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
16. 森岡一朗 (80437467)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
17. ISHII Kazuhiro

# of Collaborated Projects: 1 results

# of Collaborated Products: 7 results
18. OKA Toshiaki

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
19. HOTTA Fumie

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
20. ITOH Norimichi

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
21. 永井拓

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Deguchi Kimiko 出口 貴美子

DEGUCHI Kimiko 出口 貴美子

出口 貴美子 デグチ キミコ

Research Projects

Research Products

Co-Researchers

早産児に対する発達支援プログラムの開発と評価：神経発達症へのプロアクティブな介入

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Evaluation of parent training using online materials: Early developmental support in a Community

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Analysis of pathological mechanism of cognitive impairment and neurodevelopmental disorder observed in the new model mouse of extremely preterm infantsPrincipal Investigator

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Investigation of the mechanism of ischemic brain injury in extremely preterm infantsPrincipal Investigator

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The study on mechanisms, causes and prevention of childhood injuries-regional, age and diseases specificity

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Establishment and analysis of a new mouse model of ischemic brain injuries in extremely preterm infantsPrincipal Investigator

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Molecular basis for the complex neurocristopathy PCWH and mechanisms underlying SOX10 allelic affinity

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Pathological study of higher brain dysfunction as a neurological outcome in extremely preterm infantsPrincipal Investigator

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周産期脳虚血性障害の治療法開発を目指した基礎研究:リーリン回路の神経成長促進作用

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超未熟児に伴う脳障害の病態研究-神経幹細胞障害モデルと幹細胞移植治療への展望

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胎児、新生児の脳室周囲白室軟化に関する分子発生病理学的研究Principal Investigator

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脳室周囲白質軟化の発生に関する細胞生物学的研究Principal Investigator

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[Journal Article] Human neocortical development as a basis to understand mechanisms underlying neurodevelopmental disabilities in extremely preterm infants2020

Author(s)

Deguchi Kimiko 出口貴美子

DEGUCHI Kimiko 出口貴美子

出口貴美子デグチキミコ