Hosoi Yoshio 細井義夫

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HOSOI Yoshio 細井義夫

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Researcher Number	50238747
Other IDs
External Links
Affiliation (Current)	2025: 東北大学, 医学系研究科, 教授
Affiliation (based on the past Project Information) *help	2020 – 2023: 東北大学, 医学系研究科, 教授 2016 – 2017: 東北大学, 医学系研究科, 教授 2012 – 2016: 東北大学, 医学(系)研究科(研究院), 教授 2009 – 2011: Niigata University, 原爆放射線医科学研究所, 教授 2008 – 2009: Niigata University, 医歯学系, 教授 … More 2007: The University of Tokyo, 大学院・医学系研究科, 准教授 2006: 東京大学, 大学院医学系研究科, 助教授 1999 – 2005: University of Tokyo, Graduate School of Medicine, Associate Professor, 大学院・医学系研究科, 助教授 1997 – 1998: 東北大学, 医学部, 助教授 1995 – 1996: 東北大学, 医学部, 講師 1992 – 1993: 東北大学, 医学部, 助手 Less
Review Section/Research Field	Principal Investigator Radiation science / Radiation science / Biological Sciences / Basic Section 52040:Radiological sciences-related Except Principal Investigator Radiation science / Radiation science / 放射線5生物学 / Biological Sciences / Dermatology
Keywords	Principal Investigator 放射線 / DNA-PK / DNA修復 / 癌 / ATM / 放射線感受性 / ataxia telangiectasia / suramin / ionizing radiation / wortmannin … More / phosphatidylinositol 3-kinase / mitomycin / bleomycin / EGF受容体 / Muse細胞 / 放射線障害 / 幹細胞 / ミューズ細胞 / 放射線抵抗性 / がん幹細胞 / 間葉系幹細胞 / DNA double strand breaks / single strand DNA / 2重鎖切断 / DNA2重鎖切断 / 1本鎖DNA / Cancer / DNA repair / Ionizing radiation / radiation sensitivity / scidマウス / PI-3キナーゼ / NSAIDs / ICM-1 / 非ステロイド性抗炎症薬 / 血管内皮細胞 / mTOR / 低栄養 / 低酸素 / 活性酸素 / ERK / 上皮増殖因子受容体 / ATR / Sp1 / 放射線感受 / 細胞増殖因子受容体 / SHP-2 / Src / Ku80 / Ku70 / 毛細血管拡張性運動失調症 / アンチセンス / AT / SV40 / 癌化 / ATDC … More Except Principal Investigator Radiation fibrosis / rat / gene expression / heart / ischemia / endothelin / radiation (X-ray) / cardiomyocytes / 還元酵素 / ラット / 遺伝子発現 / 心臓 / 心筋梗塞 / エンドセリン / 放射線(X線) / 心筋細胞 / macrophage / Radiation pneumonitis / マクロファージ / 照射後の肺障害 / Cell Communication / Growth Factor / Immuno-modulator / Prevention of Hazards / Acute Effects / Radiation / 抗生物質 / 免疫賦活剤 / 骨髄死 / 放射線障害 / 血管内皮細胞 / 低線量 / X線 / フォトブリーチング / ギャップジャンクション / 腸死 / アポトーシス / p41 / MOLT-4 / XRCC4 / 放射線感受性 / 感受性 / Wortmannin / c-Myc / 温熱 / 放射線 / 細胞死 / 放射線誘発アポトーシス / DNA-PK / MOLT-4細胞 / p53 / c-myc / JNK / SAPK / p41タンパク / シグナル伝達 / 放射線誘発細胞死 / Mutaマウス / 突然変異 / 皮膚 / 太陽光 / 紫外線 Less

Treatment of radiation damage in normal tissues using Muse cells and elucidation of the mechanism of radiation resistance of stem cellsPrincipal Investigator
- Principal Investigator
  
  Hosoi Yoshio
- Project Period (FY)
  2020 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 52040:Radiological sciences-related
- Research Institution
  Tohoku University
Study on effects of modified mTOR activities under hypoxia and nutrient starvation on radiation sensitivity of cancer cells.Principal Investigator
- Principal Investigator
  
  Hosoi Yoshio
- Project Period (FY)
  2014 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Radiation science
- Research Institution
  Tohoku University
NSAIDs diclofenac, indomethacin, and meloxicam highly upregulate expression of ICAM-1 and COX-2 induced by X-irradiation in human endothelial cellsPrincipal Investigator
- Principal Investigator
  
  Hosoi Yoshio
- Project Period (FY)
  2014 – 2016
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Radiation science
- Research Institution
  Tohoku University
Radiosensitization of radioresistant cancer stem cells by inhibition of ATMPrincipal Investigator
- Principal Investigator
  
  HOSOI Yoshio
- Project Period (FY)
  2011 – 2013
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Radiation science
- Research Institution
  Tohoku University
  Hiroshima University
COX‐2・EGF受容体・DNA‐PK・ATMのクロストーク解析による放射線増感Principal Investigator
- Principal Investigator
  
  細井義夫
- Project Period (FY)
  2008 – 2010
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Radiation science
- Research Institution
  Hiroshima University
  Niigata University
Radiation sensitization though regulation of transcriptional factor Sp1Principal Investigator
- Principal Investigator
  
  HOSOI Yoshio
- Project Period (FY)
  2006 – 2009
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Radiation science
- Research Institution
  Niigata University
  The University of Tokyo
放射線によるEGF受容体活性化の原因解明とDNA損傷修復系への影響Principal Investigator
- Principal Investigator
  
  細井義夫
- Project Period (FY)
  2004 – 2005
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  Radiation science
- Research Institution
  The University of Tokyo
Development of preventive method of ischemia induced by radiation therapy
- Principal Investigator
  
  SUZUKI Takahiko
- Project Period (FY)
  2004 – 2005
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Radiation science
- Research Institution
  The University of Tokyo
DNA-PK、ATMの転写調節解析とその結果を利用した放射線感受性制御・予測Principal Investigator
- Principal Investigator
  
  細井義夫
- Project Period (FY)
  2003
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  The University of Tokyo
Inhibition of DNA-PK activity and radio-sensitization induced by single strand DNAPrincipal Investigator
- Principal Investigator
  
  HOSOI Yoshio
- Project Period (FY)
  2003 – 2005
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Radiation science
- Research Institution
  The University of Tokyo
DNA依存性プロテインキナーゼを利用した放射線感受性予測と放射線増感Principal Investigator
- Principal Investigator
  
  細井義夫
- Project Period (FY)
  2002
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  The University of Tokyo
DNA依存性プロテインキナーゼを利用した放射線感受性予測と放射線増感Principal Investigator
- Principal Investigator
  
  細井義夫
- Project Period (FY)
  2001
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas (C)
- Review Section
  
  Biological Sciences
- Research Institution
  The University of Tokyo
合成2本鎖DNAによる放射線増感剤・遺伝子治療法の開発Principal Investigator
- Principal Investigator
  
  細井義夫
- Project Period (FY)
  2001 – 2002
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  Radiation science
- Research Institution
  The University of Tokyo
放射線細胞応答メカニズムと感受性予測
- Principal Investigator
  
  SUZUKI Norio
- Project Period (FY)
  2000 – 2004
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  International University of Health and Welfare
  The University of Tokyo
Inhibition of DNA-PK activity by phosphorothioate oligonucleotidesPrincipal Investigator
- Principal Investigator
  
  HOSOI Yoshio
- Project Period (FY)
  2000 – 2002
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Radiation science
- Research Institution
  The University of Tokyo
Study to control radiation lung damages.
- Principal Investigator
  
  SUZUKI Norio
- Project Period (FY)
  1998 – 1999
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Radiation science
- Research Institution
  The University of Tokyo
Effect of a phosphatidylinositol 3-kinase inhibitor wortmannin on radiation and bleomycin sensitivities.Principal Investigator
- Principal Investigator
  
  HOSOI Yoshio
- Project Period (FY)
  1997 – 1998
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Radiation science
- Research Institution
  Tohoku University
アンチセンスATM遺伝子治療による放射線増感効果Principal Investigator
- Principal Investigator
  
  細井義夫
- Project Period (FY)
  1996
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Tohoku University
皮膚における紫外線誘発突然変異
- Principal Investigator
  
  小野哲也
- Project Period (FY)
  1996
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Dermatology
- Research Institution
  Tohoku University
アンチセンスKup70/80DNAを用いた放射線遺伝子治療Principal Investigator
- Principal Investigator
  
  細井義夫
- Project Period (FY)
  1996
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Radiation science
- Research Institution
  Tohoku University
ヒト腫瘍の放射線感受性因子としてのATDC遺伝子発現の関与Principal Investigator
- Principal Investigator
  
  細井義夫
- Project Period (FY)
  1995
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  Radiation science
- Research Institution
  Tohoku University
A search of methods to enhance the capacity to resist against radiation-induced acute injuries.
- Principal Investigator
  
  ONO Tetsuya
- Project Period (FY)
  1992 – 1993
- Research Category
  
  Grant-in-Aid for General Scientific Research (B)
- Research Field
  
  放射線5生物学
- Research Institution
  TOHOKU UNIVERSITY

[Book] がん放射線療法 20102010
- Author(s)
  細井義夫(分担)大西洋, 唐澤克之, 唐澤久美子監修
- Publisher
  (株)篠原出版社
- Data Source
  KAKENHI-PROJECT-20659187
[Book] がん放射線療法 20102010
- Author(s)
  細井義夫(分担) 大西洋, 唐澤克之, 唐澤久美子監修
- Total Pages
  1247
- Publisher
  (株)篠原出版者
- Data Source
  KAKENHI-PROJECT-18390330
[Book] 放射線医科学-生体と放射線・電磁波・超音波-(放射線によるDNA損傷と染色体異常)(大西武雄監修)2007
- Author(s)
  細井義夫
- Publisher
  学会出版センター
- Data Source
  KAKENHI-PROJECT-18390330
[Book] Low-Dose Radiation Exposures and Bio-Defense System2005
- Author(s)
  Hosoi Y, et al.
- Total Pages
  117
- Publisher
  Institute for Environmental Sciences, Japan
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15390357
[Book] がん放射線療法2010(大西洋, 唐澤克之, 唐澤久美子監修)(放射線腫瘍学の生物学的基礎)
- Author(s)
  細井義夫
- Publisher
  (株)篠原出版社
- Data Source
  KAKENHI-PROJECT-18390330
[Journal Article] Knockdown of AMPKα decreases ATM expression and increases radiosensitivity under hypoxia and nutrient starvation in an SV40-transformed human fibroblast cell line, LM217.2018
- Author(s)
  Murata Y, Hashimoto T, Urushihara Y, Shiga S, Takeda K, Jingu K, Hosoi Y.
- Journal Title
  
  Biochemical and Biophysical Research Communications
  
  Volume: 495 Issue: 4 Pages: 2566-2572
- DOI
  10.1016/j.bbrc.2017.12.141
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-26293271, KAKENHI-PROJECT-17H06528, KAKENHI-PROJECT-17K16416
[Journal Article] A chemical modulator of p53 transactivation that acts as a radioprotective agonist.2018
- Author(s)
  Akinori Morita, Ippei Takahashi, Megumi Sasatani, Shin Aoki, Bing Wang, Shinya Ariyasu, Kaoru Tanaka, Tetsuji Yamaguchi, Akiko Sawa, Yurie Nishi, Tatsuro Teraoka, Shohei Ujita, Yosuke Kawate, Chihiro Yanagawa, Keiji Tanimoto, Atsushi Enomoto, Mitsuru Nenoi, Kenji Kamiya, Yasushi Nagata, Yoshio Hosoi and Toshiya Inaba
- Journal Title
  
  Molecular Cancer Therapeutics
  
  Volume: 17 Issue: 2 Pages: 432-442
- DOI
  10.1158/1535-7163.mct-16-0554
- NAID
  120006552353
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16K10396, KAKENHI-PROJECT-17K00553, KAKENHI-PROJECT-17K08225, KAKENHI-PROJECT-17K10434, KAKENHI-PROJECT-26293271, KAKENHI-PROJECT-15K11252, KAKENHI-PROJECT-20K20310
[Journal Article] NSAIDs diclofenac, indomethacin, and meloxicam highly upregulate expression of ICAM-1 and COX-2 induced by X-irradiation in human endothelial cells2016
- Author(s)
  Y Uehara, Y Murata, S Shiga, Y Hosoi
- Journal Title
  
  Biochemical and Biophysical Research Communications
  
  Volume: 479 Issue: 4 Pages: 847-852
- DOI
  10.1016/j.bbrc.2016.09.120
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-26293271, KAKENHI-PROJECT-26670547, KAKENHI-PROJECT-26860974
[Journal Article] Activation of mTORC1 under nutrient starvation conditions increases cellular radiosensitivity in human liver cancer cell lines, HepG2 and HuH6.2015
- Author(s)
  Murata Y, Uehara Y, Hosoi Y
- Journal Title
  
  Biochemical and Biophysical Research Communications
  
  Volume: 468 Pages: 684-690
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-26670547
[Journal Article] Inhibition of β-catenin and STAT3 with curcumin analog suppresses gastric carcinogenesis in vivo: a novel candidate for gastric cancer treatment.2015
- Author(s)
  Uehara Y, Inoue M, Fukuda K, Yamakoshi H, Hosoi Y, Kanda H, Oshima M, Iwabuchi Y, Shibata H
- Journal Title
  
  Gastric Cancer
  
  Volume: 18 Pages: 774-783
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-26293271
[Journal Article] Activation of mTORC1 under nutrient starvation conditions increases cellular radiosensitivity in human liver cancer cell lines, HepG2 and HuH6.2015
- Author(s)
  Murata Y, Uehara Y, Hosoi Y
- Journal Title
  
  Biochemical and Biophysical Research Communications
  
  Volume: 468 Pages: 684-490
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-26293271
[Journal Article] Inhibition of β-catenin and STAT3 with curcumin analog suppresses gastric carcinogenesis in vivo: a novel candidate for gastric cancer treatment.2015
- Author(s)
  Uehara Y, Inoue M, Fukuda K, Yamakoshi H, Hosoi Y, Kanda H, Oshima M, Iwabuchi Y, Shibata H
- Journal Title
  
  Gastric Cancer
  
  Volume: 18 Pages: 774-783
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-26670547
[Journal Article] Requirement of mitochondria for ATM activation by extranuclear oxidative stress in cultured human hepatoblastoma cell line HepG2 cells.2014
- Author(s)
  Morita A, Murakami T, Morinaga T, Tanimoto K, Hosoi Y
- Journal Title
  
  Biochemical and Biophysical Research Communications
  
  Volume: 443 Pages: 1286-1290
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23659588
[Journal Article] Mitochondria are required for ATM activation by extranuclear oxidative stress in cultured human hepatoblastoma cell line Hep G2 cells.2014
- Author(s)
  Akinori Morita, Keiji Tanimoto, Tomoki Murakami, Takeshi Morinaga, Yoshio Hosoi.
- Journal Title
  
  Biochemical and Biophysical Research Communications
  
  Volume: 443 Issue: 4 Pages: 1286-1290
- DOI
  10.1016/j.bbrc.2013.12.139
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23592766, KAKENHI-PROJECT-23659588
[Journal Article] Sodium orthovanadate (vanadate), a potent mitigator of radiation-induced damage to the hematopoietic system in mice.2013
- Author(s)
  Wang B, Tanaka K, Morita A, Ninomiya Y, Maruyama K, Fujita K, Hosoi Y, Nenoi M: Sodium orthovanadate (vanadate), a potent mitigator of radiation-induced damage to the hematopoietic system in mice.
- Journal Title
  
  Journal of Radiation Research
  
  Volume: 54 Pages: 620-629
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23659588
[Journal Article] Evaluation of Zinc (II) chelators for inhibiting p53-mediated apoptosis2013
- Author(s)
  Morita A, Ariyasu S, Ohya S, Takahashi I, Wang B, Tanaka K, Uchida T, Okazaki H, Hanaya K, Enomoto A, Nenoi M, Ikekita M, Aoki S, Hosoi Y
- Journal Title
  
  Oncotarget
  
  Volume: 4 Pages: 2439-2450
- URL
  http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3926839/
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23659588
[Journal Article] Evaluation of Zinc (II) chelators for inhibiting p53-mediated apoptosis.2013
- Author(s)
  Morita A, Ariyasu S, Ohya S, Takahashi I, Wang B, Tanaka K, Uchida T, Okazaki H, Hanaya K, Enomoto A, Nenoi M, Ikekita M, Aoki S, Hosoi Y
- Journal Title
  
  Oncotaget
  
  Volume: 4 Pages: 2439-2450
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23659588
[Journal Article] The HSP90 inhibitor 17-allylamino-17-demethoxygeldanamycin modulates radiosensitivity by downregulating serine/threonine kinase 38 via Sp1 inhibition.2013
- Author(s)
  Enomoto A, Fukasawa T, Takamatsub N, Itob M, Moritac A, Hosoi Y, Miyagawa K
- Journal Title
  
  European Journal of Cancer
  
  Volume: 49 Pages: 3547-3558
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23659588
[Journal Article] The HSP90 inhibitor 17-allylamino-17-demethoxygeldanamycin modulates radiosensitivity by downregulating serine/threonine kinase 38 via Sp1 inhibition2013
- Author(s)
  Atsushi Enomoto
- Journal Title
  
  European Journal of Cancer
  
  Volume: 48 Issue: 16 Pages: 3547-3558
- DOI
  10.1016/j.ejca.2013.06.034
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-22132003, KAKENHI-PROJECT-23591834, KAKENHI-PROJECT-23659588, KAKENHI-PROJECT-24390289
[Journal Article] Sodium orthovanadate (vanadate), a potent mitigator of radiation-induced damage to the hematopoietic system in mice2013
- Author(s)
  Wang B, Tanaka K, Morita A, Ninomiya Y, Maruyama K, Fujita K, Hosoi Y, Nenoi M
- Journal Title
  
  J. Radiat. Res
  
  Volume: 54 Issue: 4 Pages: 620-629
- DOI
  10.1093/jrr/rrs140
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23659588, KAKENHI-PROJECT-25340041
[Journal Article] Evacuation from the restricted zone of the damaged Fukushima nuclear power plant ; facing with the reality.2011
- Author(s)
  Taniguchi K, Hirohashi N, Iwasaki Y, Hosoi Y, Kamiya K
- Journal Title
  
  Lancet
  
  Volume: (in press)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20659187
[Journal Article] 増殖因子受容体活性化によるDNA損傷修復の制御2011
- Author(s)
  細井義夫
- Journal Title
  
  細胞 The CELL
  
  Volume: 43 Pages: 207-210
- Data Source
  KAKENHI-PROJECT-18390330
[Journal Article] 増殖因子受容体活性化によるDNA損傷修復の制御2011
- Author(s)
  細井義夫
- Journal Title
  
  細胞 The CELL
  
  Volume: 43 Pages: 207-210
- Data Source
  KAKENHI-PROJECT-20659187
[Journal Article] Evacuation from the restricted zone of the damaged Fukushima nuclear power plant ; facing with the reality.2011
- Author(s)
  Taniguchi K, Hirohashi N, Iwasaki Y, Hosoi Y, Kamiya K
- Journal Title
  
  Lancet
  
  Volume: (in press)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18390330
[Journal Article] Edaravone, a known free radical scavenger, enhances X-ray-induced apoptosis at low concentrations.2010
- Author(s)
  Sasano N, Enomoto A, Hosoi Y, Katsumura Y, Matsumoto Y, Morita A, Shiraishi K, Miyagawa K, Igaki H, Nakagawa K
- Journal Title
  
  Cancer Letters
  
  Volume: 293 Pages: 52-57
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18390330
[Journal Article] 前立腺癌治療を例として考えるLQモデルと寡分割照射2010
- Author(s)
  細井義夫
- Journal Title
  
  癌の臨床
  
  Volume: 56 Pages: 445-449
- Data Source
  KAKENHI-PROJECT-18390330
[Journal Article] 前立腺癌治療を例として考えるLQモデルと寡分割照射2010
- Author(s)
  細井義夫
- Journal Title
  
  癌の臨床 56
  
  Pages: 445-449
- Data Source
  KAKENHI-PROJECT-18390330
[Journal Article] 増殖因子受容体活性化によるDNA損傷修復の制御2010
- Author(s)
  細井義夫
- Journal Title
  
  細胞The CELL 43
  
  Pages: 207-210
- Data Source
  KAKENHI-PROJECT-18390330
[Journal Article] 前立腺癌治療を例として考えるLQモデルと寡分割照射2010
- Author(s)
  細井義夫
- Journal Title
  
  癌の臨床
  
  Volume: 56 Pages: 445-449
- Data Source
  KAKENHI-PROJECT-20659187
[Journal Article] Sodium orthovanadate inhibits p53-mediated apoptosis.2010
- Author(s)
  Morita Q, Yamamoto S, Sang B, Tanaka, K, Suzuki N, Aoki S, Ito A, Nanao T, Ohya S, Yoshino M, Zhu J, Enomoto A, Matsumoto Y, Funatsu O, 細井義夫, Ikekita M
- Journal Title
  
  Cancer Research 70
  
  Pages: 257-265
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18390330
[Journal Article] Edaravone, a known free radical scavenger, enhances X-ray-induced apoptosis at low concentrations.2010
- Author(s)
  Sasano N, Enomoto A, Hosoi Y, Katsumura Y, Matsumoto Y, Morita A, Shiraishi K, Miyagawa K, Igaki H, Nakagawa K
- Journal Title
  
  Cancer Letters
  
  Volume: 293 Pages: 52-57
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20659187
[Journal Article] Edaravone, a known free radical scavenger, enhances X-ray-induced apoptosis at low concentrations.2010
- Author(s)
  Sasano N, Enomoto A, 細井義夫, Katsumura Y, Matsumoto Y, Morita A, Shiraishi K, Miyagawa K, Igaki H, Nakagawa K
- Journal Title
  
  Cancer Letters 293
  
  Pages: 52-57
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18390330
[Journal Article] Sodium orthovanadate inhibits p53-mediated apoptosis.2010
- Author(s)
  Morita A, Yamamoto S, Sang B, Tanaka, K, Suzuki N, Aoki S, Ito A, Nanao T, Ohya S, Yoshino M, Zhu J, Enomoto A, Matsumoto Y, Funatsu O, Hosoi Y, Ikekita M
- Journal Title
  
  Cancer Research
  
  Volume: 70 Pages: 257-265
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20659187
[Journal Article] Sodium orthovanadate inhibits p53-mediated apoptosis.2010
- Author(s)
  Morita A, Yamamoto S, Sang B, Tanaka, K, Suzuki N, Aoki S, Ito A, Nanao T, Ohya S, Yoshino M, Zhu J, Enomoto A, Matsumoto Y, Funatsu O, Hosoi Y, Ikekita M
- Journal Title
  
  Cancer Research
  
  Volume: 70 Pages: 257-265
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18390330
[Journal Article] Dysbindin-1, a schizophrenia-related protein, functionally interacts with the DNA-dependent protein kinase complex in an isoform-dependent manner.2009
- Author(s)
  Oyama S, Yamakawa H, Sasagawa N, Hosoi Y, Futai E, Ishiura S
- Journal Title
  
  PloS ONE
  
  Volume: 4 Pages: 1-12
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18390330
[Journal Article] Dysbindin-1, a schizophrenia-related protein, functionally interacts with the DNA-dependent protein kinase complex in an isoform dependent manner.2009
- Author(s)
  Oyama S, Yamakawa H, Sasagawa N, 細井義夫, Futai E, Ishiura S
- Journal Title
  
  PloS ONE 4
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18390330
[Journal Article] Dysbindin-1, a schizophrenia-related protein, functionally interacts with the DNA-dependent protein kinase complex in an isoform-dependent manner.2009
- Author(s)
  Oyama S, Yamakawa H, Sasagawa N, Hosoi Y, Futai K, Ishiura S
- Journal Title
  
  PloS ONE 4
  
  Pages: 1-12
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20659187
[Journal Article] Umani taste dysfunction in patients receiving radiotherapy for head and neck cancer.2009
- Author(s)
  Yamashita H, Nakagawa K, 細井義夫, Kurokawa A., Fukuda Y, Matusmoto I, Misaka T, Abe K
- Journal Title
  
  Oral Oncology 45
  
  Pages: 19-23
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18390330
[Journal Article] Umani taste dysfunction in patients receiving radiotherapy for head and neck cancer.2009
- Author(s)
  Yamashita H, Nakagawa K, Hosoi Y, Kurokawa A., Fukuda Y, Matusmoto I, Misaka T, Abe K
- Journal Title
  
  Oral Oncology 45
  
  Pages: 19-23
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20659187
[Journal Article] Umani taste dysfunction in patients receiving radiotherapy for head and neck cancer.2009
- Author(s)
  Yamashita H, Nakagawa K, Hosoi Y, Kurokawa A., Fukuda Y, Matusmoto I, Misaka T, Abe K
- Journal Title
  
  Oral Oncology
  
  Volume: 45 Pages: 19-23
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18390330
[Journal Article] 放射線増感剤・防護剤の現状と展望2009
- Author(s)
  細井義夫
- Journal Title
  
  治療学
  
  Volume: 43 Pages: 711-714
- Data Source
  KAKENHI-PROJECT-18390330
[Journal Article] Sodium orthovanadate inhibits p53-mediated apoptosis.2009
- Author(s)
  Morita Q, Yamamoto S, Sang B, Tanaka, K, Suzuki N, Aoki S, Ito A, Nanao T, Ohya S, Yoshino M, Zhu J, Enomoto A, Matsumoto Y, Funatsu O, Hosoi Y, Ikekita M
- Journal Title
  
  Cancer Research 70
  
  Pages: 257-265
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20659187
[Journal Article] 放射線増感剤・防護剤の現状と展望2009
- Author(s)
  細井義夫
- Journal Title
  
  治療学 43
  
  Pages: 711-714
- Data Source
  KAKENHI-PROJECT-18390330
[Journal Article] Negative regulation of MEKK1/2 signaling by Serine-Threonine Kinase 38 (STK38)2008
- Author(s)
  Enomoto A, Kido N, Ito M, Morita A, Matsumoto Y, Takamatsu N, Hosoi Y, Miyagawa K
- Journal Title
  
  Oncogene 27
  
  Pages: 1930-1938
- Data Source
  KAKENHI-PROJECT-18390330
[Journal Article] Pathological changes in the gastrointestinal tract of a heavily radiation-exposed worker at the Tokai-mura criticality accident2008
- Author(s)
  Igaki H, Nakagawa K, Uozaki H, Akahane M, Hosoi Y, Fukayama M, Miyagawa K, Akashi M, Ohtomo K, Maekawa K
- Journal Title
  
  Journal of Radiation Research 49
  
  Pages: 55-62
- NAID
  110006570528
- Data Source
  KAKENHI-PROJECT-18390330
[Journal Article] Pathological changes in the gastrointestinal tract of a heavily radiation-exposed worker at the Tokai-mura criticality accident.2008
- Author(s)
  Igaki H, Nakagawa K, UozakiH, Akahane M, Hosoi Y, Fukayama M, Miyagawa K, Akashi M, Ohtomo K, Maekawa K
- Journal Title
  
  Journal of Radiation Research 49
  
  Pages: 55-62
- NAID
  110006570528
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20659187
[Journal Article] Negative regulation of MEKK1/2 signaling by Serine-Threonine Kinase 38 (STK38).2008
- Author(s)
  Enomoto A, Kido N, Ito M, Morita A, Matsumoto Y, Takamatsu N, 細井義夫, Miyagawa K
- Journal Title
  
  Oncogene 27
  
  Pages: 1930-1938
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18390330
[Journal Article] Negative regulation of MEKK1/2 signaling by Serine-Threonine Kinase 38 (STK38).2008
- Author(s)
  Enomoto A, Kido N, Ito M, Morita A, Matsumoto Y, Takamatsu N. Hosoi Y, Miyagawa K
- Journal Title
  
  Oncogene 27
  
  Pages: 1930-1938
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20659187
[Journal Article] Pathological changes in the gastrointestinal tract of a heavily radiation-exposed worker at the Tokai-mura criticality accident.2008
- Author(s)
  Igaki H, Nakagawa K, Uozaki H, Akahane M, Hosoi Y, Fukayama M, Miyagawa K, Akashi M, Ohtomo K, Maekawa K
- Journal Title
  
  Journal of Radiation Research 49
  
  Pages: 55-62
- NAID
  110006570528
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18390330
[Journal Article] Pathological changes in the gastrointestinal tract of a heavily radiation-exposed worker at the Tokai-mura criticality accident.2008
- Author(s)
  Igaki H, Nakagawa K, Uozaki H, Akahane M, 細井義夫, Fukayama M, Miyagawa K, Akashi M, Ohtomo K, Maekawa K
- Journal Title
  
  Journal of Radiation Research 49
  
  Pages: 55-62
- NAID
  110006570528
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18390330
[Journal Article] Preoperative radiation response evaluated by 18-Fluorodeoxyglucose positron emission tomography predicts survival in locally advanced rectal cancer.2008
- Author(s)
  Nakagawa K, Yamashita H, Nakamura N, Igaki H, Tago M, 細井義夫, Momose T, Ohtomo K, Muto T, Nagawa H
- Journal Title
  
  Dis Colon Rectum 51
  
  Pages: 1055-1060
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18390330
[Journal Article] Negative regulation of MEKK1/2 signaling by Serine-Threonine Kinase 38(STK38)2008
- Author(s)
  Enomoto A, Kido N, Ito M, Morlta A, Matsumoto Y, Takamatsu N, Hosoi Y, Miyagawa K
- Journal Title
  
  Oncogene 27
  
  Pages: 1930-1938
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18390330
[Journal Article] Negative regulation of MEKK1/2 signaling by Serine-Threonine Kinase 38 (STK38).2008
- Author(s)
  Enomoto A, Kido N, Ito M, Morita A, Matsumoto Y, Takamatsu N, Hosoi Y, Miyagawa K
- Journal Title
  
  Oncogene 27
  
  Pages: 1930-1938
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18390330
[Journal Article] Free radical scavenger Edaravone suppresses X-ray-induced apoptosis through p53 inhibition in MOLT-4 cells2007
- Author(s)
  Sasano N, Enomoto A, Hosoi Y, Katsumura Y, Matsumoto Y, Shiraishi K, Miyagawa K, Igaki H, Nakagawa K
- Journal Title
  
  Journal of Radiation Research 48
  
  Pages: 495-503
- NAID
  110006452332
- Data Source
  KAKENHI-PROJECT-18390330
[Journal Article] Free radical scavenger Edaravone suppresses X-ray-induced apoptosis through p53 inhibition in MOLT-4 cells.2007
- Author(s)
  Sasano N, Enomoto A, 細井義夫, Katsumura Y, Matsumoto Y, Shiraishi K, Miyagawa K, Igaki H, Nakagawa K
- Journal Title
  
  Journal of Radiation Research 48
  
  Pages: 495-503
- NAID
  110006452332
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18390330
[Journal Article] Free radical scavenger Edaravone suppresses X-ray-induced apoptosisthrough p53 inhibition in MOLT-4 cells2007
- Author(s)
  Sasano N, Enomoto A, Hosoi X, Katsumura Y, Matsumoto Y, Shiraishi K, Miyagawa K, Igaki H, Nakaawa K
- Journal Title
  
  Journal of Radiation Research 48
  
  Pages: 495-503
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18390330
[Journal Article] Src tyrosine kinase inhibitor PP2 suppresses ERK1/2 activation and epidermal growth factor receptor transactivation by X-irradiation.2006
- Author(s)
  Li Z, Hosoi Y, Cai K, Tanno Y, Matsumoto Y, Enomoto A, Morita A, Nakagawa K, Miyagawa K
- Journal Title
  
  Biochemical and Biophysical Research Communications 342
  
  Pages: 363-368
- Data Source
  KAKENHI-PROJECT-18390330
[Journal Article] Suppression of anchorage-independent growth by expression of the ataxia-telangiectasia group D complementing gene, ATDC.2006
- Author(s)
  細井義夫, Kapp LN, Murnane JP, Matsumoto Y, Enomoto A, Ono T, Miyagawa K
- Journal Title
  
  Biochemical and Biophysical Research Communications 348
  
  Pages: 728-734
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18390330
[Journal Article] Anti-tuomor effects induced by low-dose total-body irradiation. Low-dose exposures and bio-defense system. Proceedings of the internationla symposium on low-dose radiation exposures and bio-defense system. Tanaka S, Fujikawa K, Oghiso Y.2006
- Author(s)
  細井義夫
- Journal Title
  
  Institute for Environmental Sciences, Japan.
  
  Pages: 27-29
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18390330
[Journal Article] Heterogeneous expression of DNA-dependent protein kinase in esophageal cancer and normal epithelium.2006
- Author(s)
  Tonotsuka N, 細井義夫, Miyazaki S, Miyata G, Sugawara K, Mori T, Ouchi N, Satomi S, Matsumoto Y, Nakagawa K, Miyagawa K, Ono T
- Journal Title
  
  International Journal of Molecular Medicine 18
  
  Pages: 441-447
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18390330
[Journal Article] Sodium orthovanadate suppresses DNA damage-induced caspase activation and apoptosis by inactivating p532006
- Author(s)
  Morita A, Zhu J, Suzuki N, Enomoto A, Matsumoto Y, Tomita T, Suzuki T, Ohtomo K, Hosoi Y
- Journal Title
  
  Death and Differentiation 13
  
  Pages: 499-511
- NAID
  130006999522
- Data Source
  KAKENHI-PROJECT-18390330
[Journal Article] Relation between acute & late irradiation impairment of four basic tastes and irradiated tongue volume in patients with head and neck cancer.2006
- Author(s)
  Yamashita H, Nakamura N, Abe K, Asakage T, Ohmoto M, Okada S, Matsumoto I, 細井義夫, Sasano N, Yamakawa S, Ohtomo K, Nakagawa K
- Journal Title
  
  International Journal of Radiation Oncology Biology Physics 66
  
  Pages: 1422-1429
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18390330
[Journal Article] Heterogeneous expression of DNA-dependent protein kinase in esophageal cancer and normal epithelium.2006
- Author(s)
  Tonotsuka N, Hosoi Y, Miyazaki S, Miyata G, Sugawara K, Mori T, Ouchi N, Satomi S, Matsumoto Y, Nakagawa K, Miyagawa K, Ono T
- Journal Title
  
  International Journal of Molecular Medicine 18
  
  Pages: 441-447
- Data Source
  KAKENHI-PROJECT-18390330
[Journal Article] Suppression of anchorage-independent growth by expression of the ataxia-telangiectasia group D complementing gene, ATDC.2006
- Author(s)
  Hosoi Y, Kapp LN, Murnane JP, Matsumoto Y, Enomoto A, Ono T, Miyagawa K
- Journal Title
  
  Biochemical and Biophysical Research Communications 348
  
  Pages: 728-734
- Data Source
  KAKENHI-PROJECT-18390330
[Journal Article] The association of DNA-dependent protein kinase activity with chromosomal instability and risk of cancer.2006
- Author(s)
  Someya M, Sakata K, Matsumoto Y, Yamamoto H, Monobe M, Ikeda H, Aono K, 細井義夫, Suzuki N, Hareyama M
- Journal Title
  
  Carcinogenesis 27
  
  Pages: 117-122
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18390330
[Journal Article] Sodium orthovanadate suppresses DNA damage-induced caspase activation and apoptosis by inactivating p53.2006
- Author(s)
  Morita A, Zhu J, Suzuki N, Enomoto A, Matsumoto Y, Tomita T, Suzuki T, Ohtomo K, 細井義夫
- Journal Title
  
  Cell Death and Differentiation 13
  
  Pages: 499-511
- NAID
  130006999522
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18390330
[Journal Article] Preservation of ovarian function by ovarian shielding when undergoing total body irradiation for hematopoietic stem cell transplantation : a report of two successful cases.2006
- Author(s)
  Nakagawa K, Kanda Y, Yamashita H, 細井義夫, Oshima K, Ohtomo I, Ban N, Yamakawa, S, Nakagawa S, Chiba S
- Journal Title
  
  Bone Marrow Transplantation 37
  
  Pages: 583-587
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18390330
[Journal Article] The association of DNA-dependent protein kinase activity with chromosomal instability and risk of cancer.2006
- Author(s)
  Someya M, Sakata K, Matsumoto Y, Yamamoto H, Monobe M, Ikeda H, Aono K, Hosoi Y, Suzuki N, Hareyama M
- Journal Title
  
  Carcinogenesis 27
  
  Pages: 117-122
- Data Source
  KAKENHI-PROJECT-18390330
[Journal Article] Preservation of ovarian function by ovarian shielding when undergoing total body irradiation for hematopoietic stem cell transplantation : a report of two successful cases.2006
- Author(s)
  Nakagawa K, Kanda Y, Yamashita H, Hosoi Y, Oshima K, Ohtomo I, Ban N, Yamakawa, S, Nakagawa S, Chiba S
- Journal Title
  
  Bone Marrow Transplantation 37
  
  Pages: 583-587
- Data Source
  KAKENHI-PROJECT-18390330
[Journal Article] Src tyrosine kinase inhibitor PP2 suppresses ERK1/2 activation and epidermal growth factor receptor transactivation by X-irradiation.2006
- Author(s)
  Li Z, 細井義夫, Cai K, Tanno Y, Matsumoto Y, Enomoto A, Morita A, Nakagawa K, Miyagawa K
- Journal Title
  
  Biochemical and Biophysical Research Communications 342
  
  Pages: 363-368
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18390330
[Journal Article] Low-dose exposures and bio-defense system.2005
- Author(s)
  Hosoi Y.
- Journal Title
  
  Institute for Environmental Sciences, Japan
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15390357
[Journal Article] Suramin Sensitizes Cells to Ionizing Radiation by Inactivating DNA-Dependent Protein Kinase.2004
- Author(s)
  Hosoi, Y., Suzuki N.et al.
- Journal Title
  
  Radiat.Res. 162
  
  Pages: 308-314
- Data Source
  KAKENHI-PROJECT-12217029
[Journal Article] Basics of combined chemo-radiotherapy.2004
- Author(s)
  Hosoi Y.
- Journal Title
  
  The Journal of the Japan Society of Gynecologic Oncology 22
  
  Pages: 334-342
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15390357
[Journal Article] Potentiality of DNA-dependent protein kinase to phosphorylate Ser46 of human p53.2004
- Author(s)
  Komiyama, S., Taniguchi, S., Matsumoto, Y., Tsunoda, E., Ohto, T., Suzuki, Y., Yin, H.-L., Tomita, M., Enomoto, A., Motita, A., Suzuki, T., Ohtomo, K., Hosoi, Y.et al.
- Journal Title
  
  Biochemical and Biophysical Research Communications 323
  
  Pages: 816-822
- Data Source
  KAKENHI-PROJECT-15390357
[Journal Article] Suppression of anchorage-independent growth by expression of the ataxia-telangiectasia group D complementing gene, ATDC.2004
- Author(s)
  Hosoi, Y. et al.
- Journal Title
  
  Molecular Carciogenesis (In press)
- Data Source
  KAKENHI-PROJECT-15390357
[Journal Article] Up-regulation of DNA-dependent protein kinase activity and Sp1 in colorectal cancer.2004
- Author(s)
  Hosoi, Y. et al.
- Journal Title
  
  International Journal of Oncology 25
  
  Pages: 461-468
- Data Source
  KAKENHI-PROJECT-15390357
[Journal Article] Up-regulation of DNA-dependent protein kinase activity and Sp1 in colorectal cancer.2004
- Author(s)
  Hosoi Y, et al.
- Journal Title
  
  International Journal of Oncology 25
  
  Pages: 461-468
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15390357
[Journal Article] Spontaneous mutations in Digestive tract of old mice show tissue-specific patterns of genomic instability.2004
- Author(s)
  Ono, T., Ikehata, H., Pithani.V.P., Uehara, Y., Chan, Y., Kinouchi.Y., Shimosegawa, Y., Hosoi, Y.
- Journal Title
  
  Cancer Research 64
  
  Pages: 6919-6923
- Data Source
  KAKENHI-PROJECT-16659313
[Journal Article] Radiation-induced signal transduction pathways.2004
- Author(s)
  Hosoi Y.
- Journal Title
  
  Japanese Journal of Cancer Clinics 50
  
  Pages: 1055-1060
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15390357
[Journal Article] Up-regulation of DNA-dependent protein kinase activity and Spl in colorectal cancer.2004
- Author(s)
  Hosoi Y, et al.
- Journal Title
  
  International Journal of Oncology 25
  
  Pages: 461-468
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15390357
[Journal Article] Suramin sensitizes cells to ionizing radiation by inactiveating DNA-dependent protein kinase.2004
- Author(s)
  Hosoi, Y. et al.
- Journal Title
  
  Radiation Research 162
  
  Pages: 308-314
- Data Source
  KAKENHI-PROJECT-15390357
[Journal Article] Radiosensitization by hyperthermia in the chicken B-lymphocyte cell line DT40 and its derivatives lacking nonhomologous end joining and/or homologous recombination pathways of DNA bouble-strand break repair.2004
- Author(s)
  Yin, H.L., Suzuki, Y., Matsumoto, Y., Tomita, M., Furusawa, Y., Enomoto, A., Motrita, A., Aoki, M., Yatagai, F., Suzuki, T., Hosoi, Y.et al.
- Journal Title
  
  Radiation Research 162
  
  Pages: 433-441
- Data Source
  KAKENHI-PROJECT-16659313
[Journal Article] 化学放射線療法の基礎2004
- Author(s)
  細井義夫
- Journal Title
  
  日本婦人科腫瘍学会誌 22
  
  Pages: 334-342
- NAID
  10026151968
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15390357
[Journal Article] Suppression of anchorage-independent growth by expression of the ataxia-telangiectasia group D complementing gene, ATDC.2004
- Author(s)
  Hosoi, Y. et al.
- Journal Title
  
  Molecular Carciogenesis (In press)
- Data Source
  KAKENHI-PROJECT-16659313
[Journal Article] Up-regulation of DNA-dependent protein kinase activity and Sp1 in2004
- Author(s)
  Hosoi, Y., Suzuki N.et al.
- Journal Title
  
  Int.J.Oncol. 25
  
  Pages: 461-468
- Data Source
  KAKENHI-PROJECT-12217029
[Journal Article] Spontaneous mutations in Digestive tract of old mice show tissue-specific patterns of genomic instability.2004
- Author(s)
  Ono, T., Ikehata, H., Pithani, V.P., Uehara, Y., Chan, Y., Kinouchi, Y., Shimosegawa, Y., Hosoi, Y.
- Journal Title
  
  Cancer Research 64
  
  Pages: 6919-6923
- Data Source
  KAKENHI-PROJECT-15390357
[Journal Article] Potentiality of DNA-dependent protein kinase to phosphorylate Ser46 of human p53.2004
- Author(s)
  Komiyama, S., Taniguchi, S., Matsumoto, Y., Tsunoda, E., Ohto, T., Suzuki, Y., Yin, H.-L., Tomita, M., Enomoto A., Motita A., Suzuki, T., Ohtomo, K., Hosoi, Y.et al.
- Journal Title
  
  Biochemical and Biophysical Research Communications 323
  
  Pages: 816-822
- Data Source
  KAKENHI-PROJECT-16659313
[Journal Article] Radiosensitization by hyperthermia in the chicken B-lymphocyte cell line DT40 and its derivatives lacking nonhomologous end joining and/or homologous recombination pathways of DNA bouble-strand break repair.2004
- Author(s)
  Yin, H.L., Suzuki, Y., Matsumoto, Y., Tomita, M., Furusawa, Y., Enomoto, A., Motrita, A., Aoki, M., Yatagai, F., Suzuki, T., Hosoi, Y.et al.
- Journal Title
  
  Radiation Research 162
  
  Pages: 433-441
- Data Source
  KAKENHI-PROJECT-15390357
[Journal Article] Up-regulation of DNA-dependent protein kinase activity and Sp1 in colorectal cancer.2004
- Author(s)
  Hosoi, Y. et al.
- Journal Title
  
  International Journal of Oncology 25
  
  Pages: 461-468
- Data Source
  KAKENHI-PROJECT-16659313
[Journal Article] 遺伝子レベルでの時間と空間2004
- Author(s)
  細井義夫
- Journal Title
  
  癌の臨床 50
  
  Pages: 1055-1060
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15390357
[Journal Article] Suramin sensitizes cells to ionizing radiation by inactiveating DNA-dependent protein kinase.2004
- Author(s)
  Hosoi, Y. et al.
- Journal Title
  
  Radiation Research 162
  
  Pages: 308-314
- Data Source
  KAKENHI-PROJECT-16659313
[Journal Article] Suramin sensitizes cells to ionizing radiation by inactivating DNA-dependent protein kinase.2004
- Author(s)
  Hosoi Y, et al.
- Journal Title
  
  Radiation Research 162
  
  Pages: 308-314
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15390357
[Journal Article] Evacuation from the restricted zone of the damaged Fukushima nuclear power plant ; facing with the reality.
- Author(s)
  Taniguchi K, Hirohashi N, Iwasaki Y, 細井義夫, Kamiya K
- Journal Title
  
  Lancet in press.
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18390330
[Journal Article] Umani taste dysfunction in patients receiving radiotherapy for head and neck cancer
- Author(s)
  Yamashita H, Nakagawa K, Hosoi Y, urokawa A., Fukuda Y, Matusmoto I, Misaka T, Abe K
- Journal Title
  
  Oral Oncology (in press)
- Data Source
  KAKENHI-PROJECT-18390330
[Journal Article] Preoperative radiation response evaluated by 18-Fluorodeoxyglucose positron emission tomography predicts survival in locally advanced rectal cancer
- Author(s)
  Nakagawa K, Yamashita H, Nakamura N, Igaki H, Tago M, Hosoi Y, Momose T, Ohtomo K, Muto T, Nagawa H
- Journal Title
  
  Dis Colon Rectum (in press)
- Data Source
  KAKENHI-PROJECT-18390330
[Presentation] 低酸素および低栄養状態のヒト線維芽細胞におけるAMPKによる放射線抵抗性の増加2017
- Author(s)
  村田泰彦、橋本拓磨、志賀壮一郎、武田一也、細井義夫
- Organizer
  第55回日本放射線腫瘍学会生物部会学術大会
- Data Source
  KAKENHI-PROJECT-26293271
[Presentation] 低酸素および低栄養状態のヒト線維芽細胞におけるAMPKの活性化は放射線抵抗性を増加させる2017
- Author(s)
  村田泰彦、橋本拓磨、志賀壮一郎、武田一也、細井義夫
- Organizer
  日本放射線影響学会第60回大会
- Data Source
  KAKENHI-PROJECT-26293271
[Presentation] AMPKを介した低栄養状態による低酸素状態の放射線抵抗性の増強2017
- Author(s)
  細井義夫
- Organizer
  第23回癌治療増感研究会
- Data Source
  KAKENHI-PROJECT-26293271
[Presentation] メトホルミン、ラパマイシンなどエネルギー代謝に関わる経路の制御による放射線増感の可能性2017
- Author(s)
  細井義夫
- Organizer
  第19回癌治療増感研究シンポジウム
- Place of Presentation
  奈良県文化会館（奈良市）
- Year and Date
  2017-02-03
- Data Source
  KAKENHI-PROJECT-26293271
[Presentation] AMPKを介した低栄養状態による低酸素状態の放射線抵抗性の増強2017
- Author(s)
  細井義夫、村田泰彦、橋本拓磨、志賀壮一郎、武田一也
- Organizer
  日本放射線腫瘍学会第30回大会
- Data Source
  KAKENHI-PROJECT-26293271
[Presentation] 低栄養状態のヒト肝癌細胞におけるmTORC1の活性化による放射線感受性の増加2016
- Author(s)
  村田泰彦、志賀壮一郎、細井義夫
- Organizer
  第45回放射線による制癌シンポジウム、第54回日本放射線腫瘍学会生物部会学術大会
- Place of Presentation
  I-siteなんば（大阪市）
- Year and Date
  2016-07-15
- Data Source
  KAKENHI-PROJECT-26670547
[Presentation] ヒト肝癌細胞HepG2とHuH6おける低栄養状態によるmTORC1活性化と放射線増感2016
- Author(s)
  細井義夫、村田泰彦、志賀壮一郎
- Organizer
  日本放射線腫瘍学会第29回学術大会
- Place of Presentation
  国立京都国際会館（京都市）
- Year and Date
  2016-11-25
- Data Source
  KAKENHI-PROJECT-26293271
[Presentation] 低栄養状態のヒト肝癌細胞におけるmTORC1の活性化による放射線感受性の増加2016
- Author(s)
  村田泰彦、志賀壮一郎、細井義夫
- Organizer
  日本放射線腫瘍学会生物部会学術大会
- Place of Presentation
  I-siteなんば（大阪市）
- Year and Date
  2016-07-15
- Data Source
  KAKENHI-PROJECT-26293271
[Presentation] ヒト肝癌細胞HepG2とHuH6おける低栄養状態によるmTORC1活性化と放射線増感2016
- Author(s)
  細井義夫、村田泰彦、志賀壮一郎
- Organizer
  日本放射線腫瘍学会第29回学術大会
- Place of Presentation
  国立京都国際会館（京都市）
- Year and Date
  2016-11-25
- Data Source
  KAKENHI-PROJECT-26670547
[Presentation] ヒト肝癌細胞における低栄養状態によるmTORC1の活性化は放射線感受性を増加させる2016
- Author(s)
  村田泰彦、志賀壮一郎、細井義夫
- Organizer
  日本放射線影響学会第59回大会
- Place of Presentation
  JRSアステールプラザ（広島市）
- Year and Date
  2016-10-26
- Data Source
  KAKENHI-PROJECT-26670547
[Presentation] ヒト肝癌細胞における低栄養状態によるmTORC1の活性化は放射線感受性を増加させる2016
- Author(s)
  村田泰彦、志賀壮一郎、細井義夫
- Organizer
  日本放射線影響学会第59回大会
- Place of Presentation
  JRSアステールプラザ（広島市中区）
- Year and Date
  2016-10-26
- Data Source
  KAKENHI-PROJECT-26293271
[Presentation] Effects of nutrient starvation condition on radiosensitivity of cultured cells.2015
- Author(s)
  Yasuhiko Murata, Yoshihiko Uehara, Yoshio Hosoi
- Organizer
  15th International Congress of Radiation Research (ICRR)
- Place of Presentation
  Kyoto International Conference Center, Kyoto
- Year and Date
  2015-05-25
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26670547
[Presentation] Effects of nutrient starvation condition on radiosensitivity of cultured cells.2015
- Author(s)
  Yasuhiko Murata, Yoshihiko Uehara, Yoshio Hosoi
- Organizer
  15th International Congress of Radiation Research (ICRR)
- Place of Presentation
  Kyoto International Conference Center, Kyoto
- Year and Date
  2015-05-25
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26293271
[Presentation] Synergistic effect of nonsteroidal anti-inflammatory drugs (NDAIDs) and ionizing radiation on ICAM-1 expression in HUVECs.2015
- Author(s)
  Yoshihiko Uehara, Yasuhiko Murata, Yoshio Hosoi
- Organizer
  15th International Congress of Radiation Research (ICRR)
- Place of Presentation
  Kyoto International Conference Center, Kyoto
- Year and Date
  2015-05-25
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26293271
[Presentation] Synergistic effect of nonsteroidal anti-inflammatory drugs (NDAIDs) and ionizing radiation on ICAM-1 expression in HUVECs.2015
- Author(s)
  Yoshihiko Uehara, Yasuhiko Murata, Yoshio Hosoi
- Organizer
  15th International Congress of Radiation Research (ICRR)
- Place of Presentation
  Kyoto International Conference Center, Kyoto
- Year and Date
  2015-05-25
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26670547
[Presentation] 過酸化水素・放射線によるATM を介したp53 Ser-15 のリン酸化とアポトーシス2011
- Author(s)
  森田明典、佐藤元俊、谷本圭司、細井義夫
- Organizer
  日本放射線影響学会第54回大会
- Place of Presentation
  神戸市
- Year and Date
  2011-11-19
- Data Source
  KAKENHI-PROJECT-23659588
[Presentation] 過酸化水素によるATM を介したp53 Ser-15 のリン酸化2011
- Author(s)
  細井義夫、森田明典、谷本圭司
- Organizer
  第17回国際癌治療増感研究会
- Place of Presentation
  仙台市
- Year and Date
  2011-06-24
- Data Source
  KAKENHI-PROJECT-23659588
[Presentation] 放射線によるDNA損傷と修復2010
- Author(s)
  細井義夫
- Organizer
  第1回放射線生物学セミナ
- Place of Presentation
  東京都
- Year and Date
  2010-03-13
- Data Source
  KAKENHI-PROJECT-18390330
[Presentation] 過酸化水素・放射線によるATMを介したp53 Ser15 のリン酸化2010
- Author(s)
  佐藤元俊、川口弦、青山英史、笹井啓資、細井義夫
- Organizer
  第49回日本医学放射線学会生物部会学術大会
- Place of Presentation
  札幌市
- Year and Date
  2010-07-09
- Data Source
  KAKENHI-PROJECT-23659588
[Presentation] 前立腺癌を例として考えるLQモデルと寡分割照射2010
- Author(s)
  細井義夫
- Organizer
  第40回放射線による制癌シンポジウム
- Place of Presentation
  札幌市
- Year and Date
  2010-07-10
- Data Source
  KAKENHI-PROJECT-18390330
[Presentation] 放射線によるEGF受容体・ERK1/2活性化の機序解明2010
- Author(s)
  川口弦、佐藤元俊、青山英史、笹井啓資、細井義夫
- Organizer
  第49回日本医学放射線学会生物部会学術大会
- Place of Presentation
  札幌市
- Year and Date
  2010-07-09
- Data Source
  KAKENHI-PROJECT-18390330
[Presentation] 放射線によるEGF受容体・ERK1/2活性化の機序解明2010
- Author(s)
  川口弦、佐藤元俊、青山英史、笹井啓資、細井義夫
- Organizer
  第49回日本医学放射線学会生物部会学術大会
- Place of Presentation
  札幌市
- Year and Date
  2010-07-09
- Data Source
  KAKENHI-PROJECT-20659187
[Presentation] 過酸化水素・放射線によるATMを介したp53 Ser15のリン酸化2010
- Author(s)
  佐藤元俊、川口弦、青山英史、笹井啓資、細井義夫
- Organizer
  第49回日本医学放射線学会生物部会学術大会
- Place of Presentation
  札幌市
- Year and Date
  2010-07-09
- Data Source
  KAKENHI-PROJECT-20659187
[Presentation] 前立腺癌を例として考えるLQモデルと寡分割照射2010
- Author(s)
  細井義夫
- Organizer
  第40回放射線による制癌シンポジウム
- Place of Presentation
  札幌市(招待講演)
- Year and Date
  2010-07-10
- Data Source
  KAKENHI-PROJECT-20659187
[Presentation] 過酸化水素・放射線によるATMを介したp53 Ser15のリン酸化2010
- Author(s)
  佐藤元俊、川口弦、青山英史、笹井啓資、細井義夫
- Organizer
  第49回日本医学放射線学会生物部会学術大会
- Place of Presentation
  札幌市
- Year and Date
  2010-07-09
- Data Source
  KAKENHI-PROJECT-18390330
[Presentation] 過酸化水素・放射線によるATMを介したp53 Ser-15のリン酸化2009
- Author(s)
  佐藤元俊、川口弦、竹原和宏、奥山圭介、笹井啓資、細井義夫
- Organizer
  第121回日本医学放射線学会北日本地方会
- Place of Presentation
  仙台市
- Year and Date
  2009-11-06
- Data Source
  KAKENHI-PROJECT-18390330
[Presentation] 転写因子Sp1を分子標的とした放射線増感2009
- Author(s)
  細井義夫
- Organizer
  日本放射線影響学会第52回大会
- Place of Presentation
  広島市
- Year and Date
  2009-11-11
- Data Source
  KAKENHI-PROJECT-18390330
[Presentation] 低線量粒子線照射によるERK1/2活性化2009
- Author(s)
  奥山幸介、竹原和宏、川口弦、佐藤元俊、笹井啓資、宮川清、加藤宝光、関根絵美子、高橋桃子、岡安隆一、細井義夫
- Organizer
  第48回日本医学放射線学会生物部会学術大会
- Place of Presentation
  富山市
- Year and Date
  2009-07-10
- Data Source
  KAKENHI-PROJECT-20659187
[Presentation] 過酸化水素・放射線によるATMを介したp53 Ser-15のリン酸化2009
- Author(s)
  佐藤元俊、川口弦、竹原和宏、奥山圭介、笹井啓資、細井義夫
- Organizer
  第121回日本医学放射線学会北日本地方会
- Place of Presentation
  仙台市
- Year and Date
  2009-11-06
- Data Source
  KAKENHI-PROJECT-20659187
[Presentation] 転写因子Sp1を分子標的とした放射線増感2009
- Author(s)
  細井義夫
- Organizer
  転写因子Sp1を分子標的とした放射線増感
- Place of Presentation
  広島市
- Year and Date
  2009-11-11
- Data Source
  KAKENHI-PROJECT-18390330
[Presentation] 細胞の増殖状態によるDNA2重鎖切断修復酵素の発現と放射線感受性2009
- Author(s)
  竹原和宏、奥山幸介、川口弦、佐藤元俊、笹井啓資、細井義夫
- Organizer
  第48回日本医学放射線学会生物部会学術大会
- Place of Presentation
  富山市
- Year and Date
  2009-07-10
- Data Source
  KAKENHI-PROJECT-20659187
[Presentation] 低線量重粒子線照射によるERK1/2活性化2009
- Author(s)
  奥山幸介、竹原和宏、川口弦、佐藤元俊、笹井啓資、宮川清、加藤宝光、関根絵美子、高橋桃子、岡安隆一、細井義夫
- Organizer
  第48回日本医学放射線学会生物部会学術大会
- Place of Presentation
  富山市
- Year and Date
  2009-07-10
- Data Source
  KAKENHI-PROJECT-18390330
[Presentation] 細胞の増殖状態によるDNA2重鎖切断修復酵素の発現と放射線感受性2009
- Author(s)
  竹原和宏、奥山幸介、川口弦、佐藤元俊、笹井啓資、細井義夫
- Organizer
  第48回日本医学放射線学会生物部会学術大会
- Place of Presentation
  富山市
- Year and Date
  2009-07-10
- Data Source
  KAKENHI-PROJECT-18390330
[Presentation] 低濃度エダラボンによる放射線増感効果2008
- Author(s)
  笹野仲史、榎本敦、細井義夫、松本義久、勝村庸介、森田明典、宮川清、中川恵一
- Organizer
  第47回日本医学放射線学会生物部会学術大会
- Place of Presentation
  高知市
- Year and Date
  2008-06-20
- Data Source
  KAKENHI-PROJECT-18390330
[Presentation] 低濃度エダラボンによる放射線増感効果2008
- Author(s)
  笹野仲史, 榎本敦, 細井義夫, 松本義久, 勝村庸介, 森田明典, 宮川清, 中川恵一
- Organizer
  第47回日本医学放射線学会生物部会学術大会
- Place of Presentation
  高知市
- Year and Date
  2008-06-20
- Data Source
  KAKENHI-PROJECT-20659187
[Presentation] “分子放射線治療学"-分子生物学は放射線治療を変えられるか? -2008
- Author(s)
  細井義夫
- Organizer
  第102回新潟臨床放射線学会
- Place of Presentation
  長岡市
- Year and Date
  2008-07-05
- Data Source
  KAKENHI-PROJECT-18390330
[Presentation] 分子放射線治療学-分子生物学は放射線治療を変えられるか-2008
- Author(s)
  細井義夫
- Organizer
  第102回新潟臨床放射線学会
- Place of Presentation
  長岡市
- Year and Date
  2008-07-05
- Data Source
  KAKENHI-PROJECT-18390330
[Presentation] 臨床的放射線生物学2008
- Author(s)
  細井義夫
- Organizer
  第44回日本医学放射線学会秋季臨床大会
- Place of Presentation
  郡山市
- Year and Date
  2008-10-22
- Data Source
  KAKENHI-PROJECT-20659187
[Presentation] 重粒子線照射によるEGF受容体の活性化2008
- Author(s)
  細井義夫, 榎本敦, 笹野仲史, 加藤宝光, 関根絵美子, 岡安隆一, 宮川清
- Organizer
  第67回日本医学放射線学会総会
- Place of Presentation
  横浜市
- Year and Date
  2008-04-05
- Data Source
  KAKENHI-PROJECT-20659187
[Presentation] 臨床的放射線生物学2008
- Author(s)
  細井義夫
- Organizer
  第44回日本医学放射線学会秋季臨床大会
- Place of Presentation
  郡山市
- Year and Date
  2008-10-22
- Data Source
  KAKENHI-PROJECT-18390330
[Presentation] 重力と低線量放射線の情報伝達経路2008
- Author(s)
  細井義夫
- Organizer
  宇宙利用シンポジウム(第24回)
- Place of Presentation
  東京都
- Data Source
  KAKENHI-PROJECT-18390330
[Presentation] p53を介したエアダラボン(ラジカツト)による放射線防護効果2008
- Author(s)
  細井義夫, 笹野仲史, 榎本敦, 中川恵一
- Organizer
  第38回放射線による制癌シンポジウム-基礎と臨床の対話-
- Place of Presentation
  高知市
- Year and Date
  2008-06-20
- Data Source
  KAKENHI-PROJECT-20659187
[Presentation] 重粒子線照射によるEGF受容体の活性化2008
- Author(s)
  細井義夫、榎本敦、笹野仲史、加藤宝光、関根絵美子、岡安隆一、宮川清
- Organizer
  第67回日本医学放射線学会総会
- Place of Presentation
  横浜市
- Data Source
  KAKENHI-PROJECT-18390330
[Presentation] “分子放射線治療学"-分子生物学は放射線治療を変えられるか? -2008
- Author(s)
  細井義夫
- Organizer
  第102回新潟臨床放射線学会
- Place of Presentation
  長岡市
- Year and Date
  2008-07-05
- Data Source
  KAKENHI-PROJECT-20659187
[Presentation] p53を介したエアダラボン(ラジカット)による放射線防護効果2008
- Author(s)
  細井義夫、笹野仲史、榎本敦、中川恵一
- Organizer
  第38回放射線による制癌シンポジウム-基礎と臨床の対話-
- Place of Presentation
  高知市
- Year and Date
  2008-06-20
- Data Source
  KAKENHI-PROJECT-18390330
[Presentation] Missing links in the mechanism of DNA double-strand break repair through the non-homologous end-joining pathway.2007
- Author(s)
  松本義久、Sushima M.Bhosle、富田雅典、鈴木紀夫、細井義夫、宮川清
- Organizer
  13th International Congress of Radiation Research
- Place of Presentation
  サンフランシスコ市
- Data Source
  KAKENHI-PROJECT-18390330
[Presentation] 放射線によるphosphatase不活化を介したEGF受容体活性化・放射線抵抗性化.2007
- Author(s)
  細井義夫、松本義久、榎本敦、桂真理、宮川清
- Organizer
  第66回日本医学放射線学会学術集会
- Place of Presentation
  横浜市
- Year and Date
  2007-04-06
- Data Source
  KAKENHI-PROJECT-18390330
[Presentation] 新規MAP3K結合因子の機能解析2007
- Author(s)
  榎本敦、木戸直樹、伊藤道彦、森田明典、細井義夫、宮川清
- Organizer
  日本放射線影響学会第50回大会
- Place of Presentation
  千葉市
- Data Source
  KAKENHI-PROJECT-18390330
[Presentation] エダラボンの放射線防護効果2007
- Author(s)
  笹野仲史、榎本敦、細井義夫、勝村庸介、井垣浩、白石憲史郎、宮川清、中川恵一
- Organizer
  日本放射線腫瘍学会第20回学術大会
- Place of Presentation
  福岡市
- Data Source
  KAKENHI-PROJECT-18390330
[Presentation] エダラボンの放射線防護効果2007
- Author(s)
  笹野仲史、榎本敦、細井義夫、白石憲史郎、井垣浩、勝村庸介、宮川清、中川恵一
- Organizer
  第46回日本医学放射線学会生物部会学術大会
- Place of Presentation
  つくば市
- Data Source
  KAKENHI-PROJECT-18390330
[Presentation] 放射線によるphosphatase不活化を介したEGF受容体活性化・放射線抵抗性化2007
- Author(s)
  細井義夫、松本義久、榎本敦、桂真理、宮川清
- Organizer
  第66回日本医学放射線学会学術集会
- Place of Presentation
  横浜市
- Data Source
  KAKENHI-PROJECT-18390330
[Presentation] エダラボンの放射線防護効果2007
- Author(s)
  笹野仲史、榎本敦、松本義久、細井義夫、宮川清、中川恵一
- Organizer
  第9回癌治療増感研究シンポジウム
- Place of Presentation
  奈良市
- Data Source
  KAKENHI-PROJECT-18390330
[Presentation] エダラボンの放射線防護効果2007
- Author(s)
  笹野仲史、榎本敦、細井義夫、白石憲史郎、宮川清、勝村庸介、中川恵一
- Organizer
  日本放射線影響学会第50回大会
- Place of Presentation
  千葉市
- Data Source
  KAKENHI-PROJECT-18390330
[Presentation] 重粒子線照射によるEGF受容体の活性化2007
- Author(s)
  細井義夫、榎本敦、笹野仲史、加藤宝光、関根絵美子、岡安隆一、宮川清
- Organizer
  第46回日本医学放射線学会生物部会学術大会
- Place of Presentation
  つくば市
- Data Source
  KAKENHI-PROJECT-18390330
[Presentation] 重粒子線によるEGF受容体を介したERKの活性化2007
- Author(s)
  細井義夫、榎本敦、笹野仲史、加藤宝光、関根絵美子、藤井義大、岡安隆一、宮川清
- Organizer
  日本放射線影響学会第50回大会
- Place of Presentation
  千葉市
- Data Source
  KAKENHI-PROJECT-18390330
[Presentation] 放射線によるphosphatase 不活化を介したEGF受容体活性化・放射線抵抗性化2007
- Author(s)
  細井義夫、松本義久、榎本敦、桂真理、宮川清
- Organizer
  第66 回日本医学放射線学会学術集会
- Place of Presentation
  横浜市
- Data Source
  KAKENHI-PROJECT-18390330
[Presentation] Src tyrosine kinase inhibitor PP2 suppresses activation of ERK1/2 and epidermal growth factor receptor induced by X-irradiation.2007
- Author(s)
  細井義夫、宮川清
- Organizer
  13th International Congress of Radiation Research
- Place of Presentation
  サンフランシスコ市
- Data Source
  KAKENHI-PROJECT-18390330
[Presentation] 重粒子線のよるEGF受容体活性化2007
- Author(s)
  細井義夫、榎本敦、笹野仲史、加藤宝光、関根絵美子、岡安隆一、宮川清
- Organizer
  日本放射線腫瘍学会第20回学術大会
- Place of Presentation
  福岡市
- Data Source
  KAKENHI-PROJECT-18390330
[Presentation] Transactivation of EGF receptor by X-irradiation. The 100th Anniversary of Tohoku University2007
- Author(s)
  細井義夫
- Organizer
  The 5th Japan-US Cancer Therapy Symposium & The 5th S. Takahashi Memorial International Joint Symposium.
- Place of Presentation
  仙台市
- Data Source
  KAKENHI-PROJECT-18390330
[Presentation] オルトバナジン酸ナトリウムによるp53制御メカニズムの解明2007
- Author(s)
  山本真一、森田明典、伊藤あずさ、榎本敦、松本義久、船津修、細井義夫、鈴木紀夫、池北雅彦
- Organizer
  日本放射線影響学会第50回大会
- Place of Presentation
  千葉市
- Data Source
  KAKENHI-PROJECT-18390330
[Presentation] 重粒子線照射によるEGF受容体の活性化2007
- Author(s)
  細井義夫、榎本敦、笹野仲史、加藤宝光、関根絵美子、岡安隆一、宮川清
- Organizer
  第46回日本医学放射線学会生物部会学術大会.
- Place of Presentation
  つくば市
- Year and Date
  2007-07-20
- Data Source
  KAKENHI-PROJECT-18390330
[Presentation] 新規JNKカスケード制御因子の機能解析とそれを標的としたアポトーシス増感2006
- Author(s)
  榎本敦、木戸直樹、森田明典、伊藤道彦、松本義久、細井義夫、宮川清
- Organizer
  日本放射線影響学会第49回大会
- Place of Presentation
  札幌市
- Data Source
  KAKENHI-PROJECT-18390330
[Presentation] Sp1によるDNA2重鎖切断修復酵素の転写制御と放射線感受性制御2006
- Author(s)
  細井義夫、丹野悠司、松本義久、榎本敦、冨田雅典、高倉かほる、宮川清
- Organizer
  日本放射線腫瘍学会第19回学術大会
- Place of Presentation
  仙台市
- Data Source
  KAKENHI-PROJECT-18390330
[Presentation] 低線量全身照射による癌転移抑制効果2006
- Author(s)
  細井義夫
- Organizer
  平成18年度サマースクールーナノの世界から宇宙まで一((社)日本アイソトープ協会主催)
- Place of Presentation
  箱根町
- Year and Date
  2006-07-27
- Data Source
  KAKENHI-PROJECT-18390330
[Presentation] Biological basis for chemo-radiotherapy.ology.2006
- Author(s)
  細井義夫
- Organizer
  IAEA/RCA Reginal Training Course on Radiation Biology for Radiation Onc
- Place of Presentation
  千葉市
- Year and Date
  2006-05-18
- Data Source
  KAKENHI-PROJECT-18390330
[Presentation] 高LET重イオンによるDNA損傷へのKu80の反応2006
- Author(s)
  和田成一、松本義久、大戸貴代、浜田信行、原孝光、船山知夫、坂下哲哉、深本花菜、柿崎竹彦、鈴木芳代、細井義夫、鈴木紀夫、小林泰彦
- Organizer
  日本放射線影響学会第49回大会
- Place of Presentation
  札幌市
- Data Source
  KAKENHI-PROJECT-18390330
[Presentation] 時間が修復に及ぼす影響の分子機構2006
- Author(s)
  細井義夫
- Organizer
  第36回放射線による制癌シンポジウム-基礎と臨床の対話
- Place of Presentation
  弘前市
- Year and Date
  2006-06-30
- Data Source
  KAKENHI-PROJECT-18390330
[Presentation] Sp1によるDNA2重鎖切断修復酵素の転写制御と放射線感受性制御2006
- Author(s)
  細井義夫, 丹野悠司, 松本義久, 榎本敦, 桂真理, 高倉かほる, 宮川清
- Organizer
  日本放射線影響学会第49 回大会
- Place of Presentation
  札幌市
- Data Source
  KAKENHI-PROJECT-18390330
[Presentation] 転写因子Sp1によるDNA2 重鎖切断修復酵素の転写制御と放射線増感2006
- Author(s)
  細井義夫
- Organizer
  第65回日本医学放射線学会学術集会
- Place of Presentation
  横浜市
- Data Source
  KAKENHI-PROJECT-18390330
[Presentation] NHEJ修復酵素群のDNA二重鎖切断部位への動員とリン酸化による制御2006
- Author(s)
  松本義久、BHOSLE Sushma M.、冨田雅典、榎本敦、森田明典、鈴木紀夫、細井義夫、宮川清
- Organizer
  日本放射線影響学会第49回大会
- Place of Presentation
  札幌市
- Data Source
  KAKENHI-PROJECT-18390330
[Presentation] 重イオンによる細胞致死効果とDNA依存性プロテインキナーゼの応答2006
- Author(s)
  冨田雅典、松本義久、細井義夫、古澤佳也、矢野安重、酒井一夫
- Organizer
  日本放射線影響学会第49回大会
- Place of Presentation
  札幌市
- Data Source
  KAKENHI-PROJECT-18390330
[Presentation] Sp1によるDNA2重鎖切断修復酵素の転写制御と放射線感受性制御2006
- Author(s)
  細井義夫、丹野悠司、松本義久、榎本敦、冨田雅典、高倉かほる、宮川清
- Organizer
  日本放射線腫瘍学会第19 回学術大会
- Place of Presentation
  日仙台市
- Data Source
  KAKENHI-PROJECT-18390330
[Presentation] Sp1によるDNA2重鎖切断修復酵素の転写制御と放射線感受性制御2006
- Author(s)
  細井義夫、丹野悠司、松本義久、榎本敦、高倉かおる、宮川清
- Organizer
  第4回日本医学放射線学会生物部会学術大会
- Place of Presentation
  弘前市
- Year and Date
  2006-07-01
- Data Source
  KAKENHI-PROJECT-18390330
[Presentation] Sp1によるDNA2重鎖切断修復酵素の転写制御と放射線感受性制御2006
- Author(s)
  細井義夫、丹野悠司、松本義久、榎本敦、桂真理、高倉かほる、宮川清
- Organizer
  日本放射線影響学会第49回大会
- Place of Presentation
  札幌市
- Data Source
  KAKENHI-PROJECT-18390330
[Presentation] エダラボンの放射線防護効果2006
- Author(s)
  笹野仲史、細井義夫、白石憲史郎、榎本敦、宮川清、勝村庸介、中川恵一
- Organizer
  日本放射線影響学会第49回大会
- Place of Presentation
  札幌市
- Data Source
  KAKENHI-PROJECT-18390330
[Presentation] 転写因子Sp1によるDNA2重鎖切断修復酵素の転写制御と放射線増感2006
- Author(s)
  細井義夫
- Organizer
  第65回日本医学放射線学会学術集会
- Place of Presentation
  横浜市
- Data Source
  KAKENHI-PROJECT-18390330
[Presentation] DNA修復関連遺伝子の低酸素応答性転写抑制機構
- Author(s)
  谷本圭司、中村秀明、河本健、加藤幸夫、檜山英三、檜山圭子、西山正彦、森田昭典、細井義夫
- Organizer
  日本放射線影響学会第54回大会
- Place of Presentation
  神戸市
- Data Source
  KAKENHI-PROJECT-23659588
[Presentation] ｐ53を標的とする新規放射線防護在の開発
- Author(s)
  森田明典、花屋堅悟、大谷聡一郎、高橋一平、王　冰、田中薫、池北雅彦、永田靖、青木伸、細井義夫
- Organizer
  日本放射線影響学会第55回大会
- Place of Presentation
  東北大学
- Data Source
  KAKENHI-PROJECT-23659588
[Presentation] 低栄養状態が培養細胞の放射線感受性に及ぼす影響
- Author(s)
  細井義夫、村田泰彦、上原芳彦
- Organizer
  日本放射線腫瘍学会第27回学術大会
- Place of Presentation
  パシフィコ横浜、横浜市
- Year and Date
  2014-12-11 – 2014-12-13
- Data Source
  KAKENHI-PROJECT-26293271
[Presentation] 過酸化水素・放射線によるATMを介したp53 Ser-15のリン酸化とアポトーシス
- Author(s)
  森田明典、佐藤元俊、谷本圭司、細井義夫
- Organizer
  日本放射線影響学会第54回大会
- Place of Presentation
  神戸市
- Data Source
  KAKENHI-PROJECT-23659588
[Presentation] 非ステロイド性抗炎症薬は放射線と相乗的に作用してヒト血管内皮細胞におけるICAM-1の発現を亢進させる
- Author(s)
  上原芳彦、村田泰彦、細井義夫
- Organizer
  日本放射線影響学会
- Place of Presentation
  かごしま県民交流センター、鹿児島市
- Year and Date
  2014-10-02 – 2014-10-04
- Data Source
  KAKENHI-PROJECT-26670547
[Presentation] 過酸化水素によるATMを介したp53 Ser-15のリン酸化
- Author(s)
  細井義夫、森田明典、谷本圭司
- Organizer
  第17回国際癌治療増感研究会(招待講演)
- Place of Presentation
  仙台市
- Data Source
  KAKENHI-PROJECT-23659588

1. IKEHATA Hironobu (90250737)

# of Collaborated Projects: 6 results

# of Collaborated Products: 0 results
2. ONO Tetsuya (00107509)

# of Collaborated Projects: 6 results

# of Collaborated Products: 0 results
3. SUZUKI Norio (10010050)

# of Collaborated Projects: 3 results

# of Collaborated Products: 2 results
4. ENOMOTO Atsushi (20323602)

# of Collaborated Projects: 2 results

# of Collaborated Products: 41 results
5. MATSUMOTO Yoshihisa (20302672)

# of Collaborated Projects: 2 results

# of Collaborated Products: 38 results
6. UEHARA Yoshihiko (30223499)

# of Collaborated Projects: 1 results

# of Collaborated Products: 5 results
7. KURISHITA Akihiro (60201472)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. YAMADA Shyogo (60158194)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. NAKAGAWA Keiichi (80188896)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. HIRANO Kazuya (80251221)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. SAKAI Kazuo (40153837)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
12. ITOH Masamitsu (80176362)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
13. SUZUKI Takahiko (10171224)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
14. 森田明典 (90334234)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
15. 橋本拓磨 (50799145)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
16. 漆原佑介 (30722269)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
17. WANG Bing

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
18. 谷本圭司

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
19. 青木伸

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Hosoi Yoshio 細井 義夫

HOSOI Yoshio 細井 義夫

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Treatment of radiation damage in normal tissues using Muse cells and elucidation of the mechanism of radiation resistance of stem cellsPrincipal Investigator

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Study on effects of modified mTOR activities under hypoxia and nutrient starvation on radiation sensitivity of cancer cells.Principal Investigator

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NSAIDs diclofenac, indomethacin, and meloxicam highly upregulate expression of ICAM-1 and COX-2 induced by X-irradiation in human endothelial cellsPrincipal Investigator

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Radiosensitization of radioresistant cancer stem cells by inhibition of ATMPrincipal Investigator

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COX‐2・EGF受容体・DNA‐PK・ATMのクロストーク解析による放射線増感Principal Investigator

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Radiation sensitization though regulation of transcriptional factor Sp1Principal Investigator

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放射線によるEGF受容体活性化の原因解明とDNA損傷修復系への影響Principal Investigator

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Development of preventive method of ischemia induced by radiation therapy

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DNA-PK、ATMの転写調節解析とその結果を利用した放射線感受性制御・予測Principal Investigator

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Inhibition of DNA-PK activity and radio-sensitization induced by single strand DNAPrincipal Investigator

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DNA依存性プロテインキナーゼを利用した放射線感受性予測と放射線増感Principal Investigator

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DNA依存性プロテインキナーゼを利用した放射線感受性予測と放射線増感Principal Investigator

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合成2本鎖DNAによる放射線増感剤・遺伝子治療法の開発Principal Investigator

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Hosoi Yoshio 細井義夫

HOSOI Yoshio 細井義夫