Hyuga Masashi 日向昌司

… Alternative Names

HYUGA Masashi 日向昌司

HYUGA Msashi 日向昌司

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Researcher Number	50251658
Other IDs
Affiliation (Current)	2025: 国立医薬品食品衛生研究所, 生物薬品部, 主任研究官
Affiliation (based on the past Project Information) *help	2014: 国立医薬品食品衛生研究所, 主任研究官 2010: 国立医薬品食品衛生研究所, 生物薬品部, 主任研究官 1996: TIT,Faculty of Bioscience and Biotechnology, Tokyo Institute of Technology Resea, 生命理工学部・生体分子工学科, 教員 1995: 東京工業大学, 生命理工学部, 寄附講座教授 1995: 東京工業大学, 生命理工学部, 教員
Review Section/Research Field	Principal Investigator Functional biochemistry Except Principal Investigator General internal medicine (including Psychosomatic medicine) / Structural biochemistry
Keywords	Principal Investigator ファージ / ランダムペプチドライブラリー / ガングリオシド Except Principal Investigator 漢方薬 / artificial enzyme substrates / endoglycoceramidase / hyaluronidase / b-galatosidase / p-nitrophenyl glycoside / zymography … More / glycosidase / コンドロイチナーゼ / 酵素の人工基質 / エンドグリコセラミダーゼ / ヒアルロニダーゼ / β-ガラクトシダーゼ / p-ニトロフェニルグリコシド / ザイモグラフィー / グリコシダーゼ / 分子標的治療薬 / 麻黄湯 / MET / EGFR-TKI / 耐性 / 非小細胞肺がん / MET阻害剤 / EGFR / Met / エルロチニブ / 薬剤耐性肺がん / 麻黄 / MDR-1 / ステロイド / 抗癌剤 / 膠原病 / 癌 / 薬剤耐性 / 東洋医学 Less

Application to molecular targeted therapy for non-small-cell lung cancer of kampo medicines having c-Met inhibitory activity
- Principal Investigator
  
  HANAWA Toshihiko
- Project Period (FY)
  2012 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  General internal medicine (including Psychosomatic medicine)
- Research Institution
  Kitasato University
Effects of kampo medicines on drug-resistance mediated by ABC transporter, MDR-1
- Principal Investigator
  
  HANAWA Toshihiko
- Project Period (FY)
  2008 – 2010
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  General internal medicine (including Psychosomatic medicine)
- Research Institution
  Kitasato University
ガングリオシドを特異的に認識するタンパク質の探索Principal Investigator
- Principal Investigator
  
  日向昌司
- Project Period (FY)
  1995
- Research Category
  
  Grant-in-Aid for Encouragement of Young Scientists (A)
- Research Field
  
  Functional biochemistry
- Research Institution
  Tokyo Institute of Technology
Highly sensitive method of glycosidase determination
- Principal Investigator
  
  YAMAGATA Tatsuya
- Project Period (FY)
  1995 – 1996
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  Structural biochemistry
- Research Institution
  Tokyo Institute of Technology

All 2014 2013 2012 2011 2010 2009 Other

All Journal Article Presentation Patent

[Journal Article] Herbacetin, a constituent of Ephedrae herba, suppresses the HGF-induced motility of human breast cancer MDA-MB-231cells by inhibiting c-Met and Akt phosphorylation2013
- Author(s)
  Sumiko Hyuga, Masashi Hyuga, Morio Yoshimura, Yoshiaki Amakura, Yukihiro Goda, and Toshihiko Hanawa
- Journal Title
  
  Planta Medica
  
  Volume: 79 Issue: 16 Pages: 1525-1530
- DOI
  10.1055/s-0033-1350899
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24590896
[Journal Article] Basic research on the use of Kampo medicines to protect against cancer recurrence and metastasis2013
- Author(s)
  Sumiko Hyuga and Toshihiko Hanawa
- Journal Title
  
  J. Trad. Med.
  
  Volume: 30 Pages: 19-26
- NAID
  130004942413
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24590896
[Journal Article] Characterization of Phenolic Constituents from Ephedra Herb Extract2013
- Author(s)
  Yoshiaki Amakura, Morio Yoshimura, Saori Yamakami, Takashi Yoshida, Daigo Wakana,　Masashi Hyuga, Sumiko Hyuga, Toshihiko Hanawa and Yukihiro Goda
- Journal Title
  
  Molecules
  
  Volume: 18 Pages: 5326-5334
- Data Source
  KAKENHI-PROJECT-24590896
[Journal Article] Effects of Kampo medicines on MDR-1-mediated multidrug resistance in human hepatocellular carcinoma HuH-7/PTX cells.2012
- Author(s)
  Sumiko Hyuga, Masumi Shiraishi, Atsushi Hori, Masashi Hyuga, and Toshihiko Hanawa
- Journal Title
  
  Biol. Pharm. Bull.
  
  Volume: 35 Pages: 1729-1739
- NAID
  130001872368
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24590896
[Journal Article] Unkeito, a traditional Kampo formula, exhibits a selective estrogen receptor modulator-like activity : Prevention of osteoporosis in ovariectomized mice.2009
- Author(s)
  Watanabe K, Hyuga S, Hyuga M, Sekiguchi A, Endo M, Tsuda T, Oikawa T, Yamaguchi T, Hanawa T
- Journal Title
  
  J.Trad Med 26
  
  Pages: 18-24
- NAID
  110007137401
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590712
[Journal Article] Corticosteroid sparing effect of hachimijiogan in Mikulicz's disease : a case report.2009
- Author(s)
  Tsuda T, Yashiro S, Gamo Y, Watanabe K, Hoshino T, Hyuga S, Oikawa T, Hanawa T
- Journal Title
  
  Kampo Med 60
  
  Pages: 513-518
- NAID
  10025974985
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590712
[Journal Article] Suppression of motility of human breast cancer cells by human serum after intake of maoto.2009
- Author(s)
  Ito H, Hyuga S, Hyuga M, Watanabe K, Tsuda T, Oikawa T, Hanawa T
- Journal Title
  
  J Trad Med 26
  
  Pages: 51-60
- NAID
  110007226237
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590712
[Patent] エフェドリン除去麻黄エキスと、その製法及び用途2013
- Inventor(s)
  花輪壽彦、日向須美子、合田幸広、日向昌司、他3名
- Industrial Property Rights Holder
  立崎仁・学校法人北里研究所・国立医薬品食品衛生研究所長
- Industrial Property Rights Type
  特許
- Industrial Property Number
  2013-240718
- Filing Date
  2013-11-21
- Data Source
  KAKENHI-PROJECT-24590896
[Patent] マルチキナーゼ阻害剤、抗癌剤、抗転移剤、薬剤耐性抑制剤、および疼2012
- Inventor(s)
  花輪壽彦、日向須美子、合田幸広、日向昌司、天倉吉章、好村守生
- Industrial Property Rights Holder
  財団法人ヒューマンサイエンス振興財団・学校法人北里研究所
- Industrial Property Rights Type
  特許
- Industrial Property Number
  2012-258719
- Filing Date
  2012-11-27
- Data Source
  KAKENHI-PROJECT-24590896
[Patent] 麻黄を成分とするMET阻害剤2010
- Inventor(s)
  花輪壽彦、日向須美子、日向昌司
- Industrial Property Rights Holder
  北里大学、財団法人ヒューマンサイエンス振興財団
- Filing Date
  2010-03-30
- Data Source
  KAKENHI-PROJECT-20590712
[Presentation] HerbacetinによるMet及びAurora kinase Bのキナーゼ活性阻害を介した抗腫瘍効果2014
- Author(s)
  日向須美子，日向昌司，好村守生，天倉吉章，合田幸広，花輪壽彦
- Organizer
  日本薬学会第134年会
- Place of Presentation
  熊本県熊本市熊本大学
- Data Source
  KAKENHI-PROJECT-24590896
[Presentation] 縮合型タンニンの簡易部分構造解析法の検討2014
- Author(s)
  好村守生，天倉吉章，山上沙織，吉田隆志，日向昌司，日向須美子，花輪壽彦，合田幸広
- Organizer
  日本薬学会第134年会
- Place of Presentation
  熊本県熊本市熊本大学
- Data Source
  KAKENHI-PROJECT-24590896
[Presentation] 癌細胞のHGF-c-Metシグナルを阻害する麻黄の活性成分・Herbacetin2013
- Author(s)
  日向須美子
- Organizer
  日本薬学会第133年会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-24590896
[Presentation] がん転移抑制効果を有する漢方薬の基礎研究から導き出された活性成分のユニークな薬理作用と臨床応用への可能性2013
- Author(s)
  日向　須美子、日向　昌司、天倉　吉章、合田　幸広、花輪　壽彦
- Organizer
  日本薬剤学会第28年会
- Place of Presentation
  愛知県名古屋市ウインクあいち
- Invited
- Data Source
  KAKENHI-PROJECT-24590896
[Presentation] 麻黄の活性成分・Herbacetinのマルチキナーゼ阻害作用2013
- Author(s)
  日向昌司、日向須美子、天倉吉章、川崎ナナ、合田幸広、花輪壽彦
- Organizer
  第30回和漢医薬学会学術大会
- Place of Presentation
  石川県金沢市金沢大学
- Data Source
  KAKENHI-PROJECT-24590896
[Presentation] Herbacetin, a biologically active constituent in Ephedrae herba, suppresses the HGF-induced motility of human breast cancer cells through inhibition of c-Met phosphorylation2013
- Author(s)
  Sumiko Hyuga, Masashi Hyuga, Yoshiaki Amakura, Yukihiro Goda, and Toshihiko Hanawa
- Organizer
  The 64th annual meeting of the Japan Society for Oriental Medicine, 3rd Academic Meeting of Global Research Network for Traditional Medicine (GRNTM), in Kagoshima, Japan
- Place of Presentation
  鹿児島県鹿児島市城山観光ホテル
- Invited
- Data Source
  KAKENHI-PROJECT-24590896
[Presentation] Recovery effect of Kampo Medicines on MDR-1-Mediated Multidrug Resistance in Hepatocellular Carcinoma HuH-7/PTX Cells2013
- Author(s)
  Masashi Hyuga, Sumiko Hyuga, Nana Kawasaki, and Toshihiko Hanawa
- Organizer
  The 72nd Annual Meeting of Japanese Cancer Association
- Place of Presentation
  神奈川県横浜市パシフィコ横浜
- Data Source
  KAKENHI-PROJECT-24590896
[Presentation] 麻黄の活性成分・Herbacetinによるがん細胞の運動能、増殖、及び腫瘍増殖の抑制2013
- Author(s)
  日向須美子、日向昌司、天倉吉章、合田幸広、花輪壽彦
- Organizer
  第30回和漢医薬学会学術大会
- Place of Presentation
  石川県金沢市金沢大学
- Data Source
  KAKENHI-PROJECT-24590896
[Presentation] Herbacetin in Ephedra Herb suppresses motility and growth of cancer cells through inhibition of Met and Aurora kinase B2013
- Author(s)
  Sumiko Hyuga, Masashi Hyuga, Yoshiaki Amakura, Yukihiro Goda, and Toshihiko Hanawa
- Organizer
  The 72nd Annual Meeting of Japanese Cancer Association
- Place of Presentation
  神奈川県横浜市パシフィコ横浜
- Data Source
  KAKENHI-PROJECT-24590896
[Presentation] 漢方薬によるがんの再発・転移防止療法をめざして～基礎研究から臨床応用へ～2012
- Author(s)
  日向須美子
- Organizer
  第29回和漢医薬学会学術大会　　シンポジウム1 「和漢医薬学とがん」
- Place of Presentation
  東京
- Invited
- Data Source
  KAKENHI-PROJECT-24590896
[Presentation] HGFにより誘導される乳癌細胞の運動能及びc-Metチロシンリン酸化の麻黄湯による抑制2011
- Author(s)
  日向須美子, ら
- Organizer
  日本薬学会第131年会
- Place of Presentation
  静岡
- Year and Date
  2011-03-30
- Data Source
  KAKENHI-PROJECT-20590712
[Presentation] Maoto, a kampo medicine, suppresses the HGF-induced motility and scattering by directly inhibiting phosphorylation of MET2009
- Author(s)
  Hyuga, et al.
- Organizer
  The 68^<th> Annual Meeting of the Japanese Cancer Assocuation (JCA2009)
- Place of Presentation
  Yokohama
- Year and Date
  2009-10-03
- Data Source
  KAKENHI-PROJECT-20590712
[Presentation] Maoto, a kampo medicine, suppresses the HGF-induced motility and scattering by directly inhibiting phosphorylation of MET2009
- Author(s)
  Hyuga, S., et al.
- Organizer
  The 68^<th> Annual Meeting of the Japanese Cancer Assocuation(JCA2009)
- Place of Presentation
  横浜
- Year and Date
  2009-10-03
- Data Source
  KAKENHI-PROJECT-20590712
[Presentation] HerbacetinのTrkAリン酸化阻害を介した神経突起伸張抑制作用及び疼痛抑制効果
- Author(s)
  日向須美子、日向昌司、天倉吉章、合田幸広、花輪壽彦
- Organizer
  第131和漢医薬学会学術大会
- Place of Presentation
  幕張メッセ国際会議場（千葉市）
- Year and Date
  2014-08-30 – 2014-08-31
- Data Source
  KAKENHI-PROJECT-24590896
[Presentation] 薬剤耐性がん細胞の抗がん剤に対する感受性を回復させる漢方薬
- Author(s)
  日向　須美子
- Organizer
  第69回日本東洋医学会関東甲信越支部学術総会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-24590896
[Presentation] 麻黄は肺癌細胞においてHGF刺激後のMET endocytosisおよびその分解を促進する
- Author(s)
  西村行生、日向須美子、日向昌司、伊藤和幸、花輪壽彦
- Organizer
  第24回日本がん転移学会学術集会・総会
- Place of Presentation
  シティプラザ大阪（大阪市）
- Year and Date
  2015-07-23 – 2015-07-24
- Data Source
  KAKENHI-PROJECT-24590896
[Presentation] エフェドリンアルカロイド除去麻黄エキス(EFM)の薬理作用
- Author(s)
  日向須美子、日向昌司、大嶋直浩、丸山卓郎、袴塚高志、天倉吉章、合田幸広、花輪壽彦
- Organizer
  日本薬学会第135年会
- Place of Presentation
  デザイン・クリエイティブセンター神戸他（神戸市）
- Year and Date
  2015-03-25 – 2015-03-28
- Data Source
  KAKENHI-PROJECT-24590896
[Presentation] エフェドリンアルカロイド除去麻黄エキス(EFM)の製造法及びその成分組成について
- Author(s)
  大嶋直浩、山下忠俊、日向須美子、日向昌司、鎌倉浩之、丸山卓郎、袴塚高志、天倉吉章、花輪壽彦、合田幸広
- Organizer
  日本薬学会第135年会
- Place of Presentation
  デザイン・クリエイティブセンター神戸他（神戸市）
- Year and Date
  2015-03-25 – 2015-03-28
- Data Source
  KAKENHI-PROJECT-24590896
[Presentation] 麻黄のcapsaisin誘発性疼痛に関する鎮痛効果
- Author(s)
  高橋純、中森俊輔、小林義典、香川聡子、神野透人、日向昌司、袴塚高志、合田幸広、日向須美子、花輪壽彦
- Organizer
  日本薬学会第135年会
- Place of Presentation
  デザイン・クリエイティブセンター神戸他（神戸市）
- Year and Date
  2015-03-25 – 2015-03-28
- Data Source
  KAKENHI-PROJECT-24590896
[Presentation] Characterization of phenolic constituents from ephedra herba extract
- Author(s)
  Yoshiaki Amakura, Morio Yoshimura, Saori Yamakami, Takashi Yoshida, Masashi Hyuga, Sumiko Hyuga, Toshihiko Hanawa, Yukihiro Goda
- Organizer
  第27回国際ポリフェノール会議
- Place of Presentation
  名古屋大学豊田講堂・シンポジオン（名古屋市）
- Year and Date
  2014-09-02 – 2014-09-06
- Data Source
  KAKENHI-PROJECT-24590896

1. HANAWA Toshihiko (40164892)

# of Collaborated Projects: 2 results

# of Collaborated Products: 21 results
2. HYUGA Sumiko (60353471)

# of Collaborated Projects: 2 results

# of Collaborated Products: 27 results
3. YAMAGATA Tatsuya (10251654)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
4. YAMAMOTO Hisao

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results

Hyuga Masashi 日向 昌司

HYUGA Masashi 日向 昌司

HYUGA Msashi 日向 昌司

Research Projects

Research Products

Co-Researchers

Application to molecular targeted therapy for non-small-cell lung cancer of kampo medicines having c-Met inhibitory activity

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Effects of kampo medicines on drug-resistance mediated by ABC transporter, MDR-1

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

ガングリオシドを特異的に認識するタンパク質の探索Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Highly sensitive method of glycosidase determination

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Herbacetin, a constituent of Ephedrae herba, suppresses the HGF-induced motility of human breast cancer MDA-MB-231cells by inhibiting c-Met and Akt phosphorylation2013

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Basic research on the use of Kampo medicines to protect against cancer recurrence and metastasis2013

Author(s)

Journal Title

NAID

Data Source

[Journal Article] Characterization of Phenolic Constituents from Ephedra Herb Extract2013

Author(s)

Journal Title

Data Source

[Journal Article] Effects of Kampo medicines on MDR-1-mediated multidrug resistance in human hepatocellular carcinoma HuH-7/PTX cells.2012

Author(s)

Journal Title

NAID

Data Source

[Journal Article] Unkeito, a traditional Kampo formula, exhibits a selective estrogen receptor modulator-like activity : Prevention of osteoporosis in ovariectomized mice.2009

Author(s)

Journal Title

NAID

Data Source

[Journal Article] Corticosteroid sparing effect of hachimijiogan in Mikulicz's disease : a case report.2009

Author(s)

Journal Title

NAID

Data Source

[Journal Article] Suppression of motility of human breast cancer cells by human serum after intake of maoto.2009

Author(s)

Journal Title

NAID

Data Source

[Patent] エフェドリン除去麻黄エキスと、その製法及び用途2013

Inventor(s)

Industrial Property Rights Holder

Industrial Property Rights Type

Industrial Property Number

Filing Date

Data Source

[Patent] マルチキナーゼ阻害剤、抗癌剤、抗転移剤、薬剤耐性抑制剤、および疼2012

Inventor(s)

Industrial Property Rights Holder

Industrial Property Rights Type

Industrial Property Number

Filing Date

Data Source

[Patent] 麻黄を成分とするMET阻害剤2010

Inventor(s)

Hyuga Masashi 日向昌司

HYUGA Masashi 日向昌司

HYUGA Msashi 日向昌司