NAKAJIMA Hiromu 中島弘

Researcher Number	50252680
External Links
Affiliation (based on the past Project Information) *help	2003: 大阪府立成人病センター研究所, 特別研究員 2002 – 2003: 大阪府立成人病センター(研究所), 研究所, 特別研究員 2001: 阪大, 医学(系)研究科(研究院), 助手 1999 – 2000: Osaka University Gradutae School of Medicine, Assistant Professor, 医学系研究科, 助手 1993 – 1998: 大阪大学, 医学部, 助手
Review Section/Research Field	Principal Investigator 内分泌・代謝学 / Endocrinology / Laboratory medicine / Metabolomics Except Principal Investigator 内分泌・代謝学 / Metabolomics
Keywords	Principal Investigator レトロウイルス / インスリン分泌 / 遺伝子クローニング / NODマウス / I型糖尿病 / 糖尿病 / cancer / specific antibody / gene cloning / epitope … More / organic acid transporter / proteomics / genomics / gene analysis / mRNAスプライシング / 遺伝子構造 / がん / 特異抗体 / エピトープ / 有機酸トランスポーター / プロテオミクス / ゲノミクス / 遺伝子検査 / gene expression / isozyme / glucose responsiveness / regulatory system / glucose metabolism / insulin secretion / pancreatic B cell / phosphofructokinase / ノックアウト / アンチセンス / アロステリック調節 / グルコースセンサー / 遺伝子発現 / アイソザイム / グルコース応答性 / 調節機構 / グルコース代謝 / 膵B細胞 / ホスホフルクトキナーゼ / gene delivery method / NOD mouse / pancreas beta-cell destruction / viral infection / disease susceptible gene / positional cloning / retrovirus / type 1 diabetes mellitus / 組織適合抗原遺伝子 / 遺伝子導入法 / 膵β細胞破壊 / ウイルス感染 / 疾患感受性遺伝子 / ポジショナルクローニング / 脂肪毒性 / NOD / ワクチン療法 / グルタミン脱炭酸酵素(GAD) / 自己抗原 / 1型糖尿病 / 発症機構 / レトロポゾン / トランスアクチベーション / インスリン依存型糖尿病 / クローニング / mRNA / DNA / HLA / 自己免疫疾患 / 膵Β細胞 … More Except Principal Investigator 糖尿病 / 膵β細胞 / MIN6 / GFAT / マウス / レトロウイルス / トランスフェクション / サイトカイン / アポトーシス / インスリン / インスリン依存型糖尿病 / ホスホフルクトキナーゼ / lipotoxicity / free fatty acids / insulin secretion / glucose toxicity / 脂肪毒性 / 遊離脂肪酸 / インスリン分泌 / 糖毒性 / Insulin resistance / Promoter / Phosphofructokinase / Otsuka Long-Evans Tokushima Fatty rat / Insulin action / Gluconeogenesis / Glycolysis / Non-insulin-dependent diabetes mellitus / 遺伝子クローニング / 遺伝子調節 / ピルビン酸キナーゼ / グルコキナーゼ / OLETF / インスリン抵抗性 / プロモーター / OLETFラット / インスリン作用 / 糖新生系 / 解糖系 / インスリン非依存型糖尿病 / プロインスリン / 骨髄移植 / 遺伝子治療 / Bc1-2 / βTc1 / 転写活性 / エイズ / gag遺伝子 / RT-PCR / 膵臓 / クローニング / Bcl-2 / βTC1 / 細胞増殖因子 / HB-EGF(heparin-binding EGF-like growth factor) / BTC(betacellulin) / ミトコンドリア / 心肥大 / 全身性カルニチン欠乏マウス / カルニチン / スプライシング / 遺伝子変異 / M-CAT / TATA / CAAT / 筋原性高尿酸血症 / 糖原病 Less

Development of molecular investigation technique using the newly identified renal organic acid transporter molecule (hyperuricemia and renal cell carcinoma).Principal Investigator
- Principal Investigator
  
  NAKAJIMA Hiromu
- Project Period (FY)
  2002 – 2003
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Laboratory medicine
- Research Institution
  Osaka Medical Center for Cancer and Cardiovascular Diseases (Research Institute)
筋埋め込み型プラスミドワクチンによる1型糖尿病の遺伝子治療法開発Principal Investigator
- Principal Investigator
  
  中島弘
- Project Period (FY)
  2000 – 2001
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Endocrinology
- Research Institution
  Osaka University
生理活性物質を用いた膵ベータ細胞グルコース不応性(脂肪毒性)の解除に関する研究Principal Investigator
- Principal Investigator
  
  中島弘
- Project Period (FY)
  2000 – 2001
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Endocrinology
- Research Institution
  Osaka University
Metabolic consideration on PFK isozymes with reference to the first and the second phase of insulin secretory response from the pancreatic beta cells.Principal Investigator
- Principal Investigator
  
  NAKAJIMA Hiromu
- Project Period (FY)
  1998 – 1999
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Metabolomics
- Research Institution
  Osaka University
Molecular mechanisms of glucose toxicity and lipotoxicity in insulin-secreting cells
- Principal Investigator
  
  NAMBA Mitsuyoshi
- Project Period (FY)
  1998 – 1999
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Metabolomics
- Research Institution
  Osaka University
IDDMの遺伝子療法:自家骨髄移植による基礎インスリン補償
- Principal Investigator
  
  花房俊昭
- Project Period (FY)
  1997 – 1998
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  内分泌・代謝学
- Research Institution
  Osaka University
レトロウイルスの膵β細胞特異的発現に基づくI型糖尿病発症の分子機構とその制御
- Principal Investigator
  
  花房俊昭
- Project Period (FY)
  1996
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Osaka University
アポトーシスによる膵β細胞死とBcl-2ファミリーによるその制御
- Principal Investigator
  
  花房俊昭
- Project Period (FY)
  1996
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  内分泌・代謝学
- Research Institution
  Osaka University
Prevention of type 1 diabetes mellitus by the regulation of pancreas-specific retrovirus expression using the transplacental gene transfer method.Principal Investigator
- Principal Investigator
  
  NAKAJIMA Hiromu
- Project Period (FY)
  1996
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  内分泌・代謝学
- Research Institution
  Osaka University
膵特異的レトロウイルスによるトランスアクチベーションを介したI型糖尿病発症機序Principal Investigator
- Principal Investigator
  
  中島弘
- Project Period (FY)
  1995
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  内分泌・代謝学
- Research Institution
  Osaka University
アポトーシスによる膵β細胞死とBcl-2ファミリーによるその制御
- Principal Investigator
  
  花房俊昭
- Project Period (FY)
  1995
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  内分泌・代謝学
- Research Institution
  Osaka University
脂肪酸代謝異常に基づく心筋症でのミトコンドリア増生の意義に関する分子生物学的研究-遺伝性全身性カルニチン欠乏マウスを用いて-
- Principal Investigator
  
  松沢佑次
- Project Period (FY)
  1994
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Osaka University
新しい細胞増殖因子(BTC,HB-EGF)による膵β細胞分化増殖作用の研究
- Principal Investigator
  
  宮川潤一郎
- Project Period (FY)
  1994
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  内分泌・代謝学
- Research Institution
  Osaka University
I型糖尿病発症におけるレトロウイルスの関与と同遺伝子の発現メカニズムの分析Principal Investigator
- Principal Investigator
  
  中島弘
- Project Period (FY)
  1994
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  内分泌・代謝学
- Research Institution
  Osaka University
筋ホスホフルクトキナーゼ欠損症の遺伝子変異と発症の分子機構
- Principal Investigator
  
  KONO Norio
- Project Period (FY)
  1992 – 1993
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Osaka University
Gene expression of glycolytic and gluconeogenic enzymes and its derangement in diabetes mellitus
- Principal Investigator
  
  KONO Norio
- Project Period (FY)
  1992 – 1994
- Research Category
  
  Grant-in-Aid for General Scientific Research (B)
- Research Field
  
  内分泌・代謝学
- Research Institution
  Osaka University

All 2003 2002

All Journal Article Book

[Book] かんじゃ想い2003
- Author(s)
  中島弘、ほか
- Total Pages
  306
- Publisher
  日総研出版
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-14572199
[Journal Article] Mechanism of the production of reactive oxygen and nitrogen species in the stomach.2003
- Author(s)
  Mikuni T, Nakajima H, et al.
- Journal Title
  
  Curr Topics Pharmacol 8
  
  Pages: 67-77
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14572199
[Journal Article] Identification of a novel variant in the phosphoenolpyruvate carboxykinase gene promoter in Japanese patienis with type 2 diabetes.2003
- Author(s)
  Horikawa Y, Nakajima H, et al.
- Journal Title
  
  Horm. Metab. Res. 35
  
  Pages: 308-312
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-14572199
[Journal Article] Determination of D-mannose in plasma by HPLC.2003
- Author(s)
  Taguchi T, Nakajima H, et al.
- Journal Title
  
  Clin Chem 49
  
  Pages: 181-183
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14572199
[Journal Article] Mechanism of the production of reactive oxygen and nitrogen species in the stomach.2003
- Author(s)
  Mikuni T, Nakajima H, et al.
- Journal Title
  
  Curr. Topics Pharmacol. 8
  
  Pages: 67-77
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-14572199
[Journal Article] Identification of a novel variant in the phosphoenolpyruvate carboxykinasegene promoter in Japanese patients with type 2 diabetes.2003
- Author(s)
  Horikawa Y, Nakajima H, et al.
- Journal Title
  
  Horm Metab Res 35
  
  Pages: 308-312
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14572199
[Journal Article] Determination of D-mannose in plasma by HPLC.2003
- Author(s)
  Taguchi T, Nakajima H, et al.
- Journal Title
  
  Clin. Chem. 49
  
  Pages: 181-183
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-14572199
[Journal Article] Radiosurgery for acromegaly.2002
- Author(s)
  Saitou Y, Nakajima H, et al.
- Journal Title
  
  Recent Res. Devel. Endocrinol. 3
  
  Pages: 1-10
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-14572199
[Journal Article] Metabolic consequence of long-term exposute of pancreatic beta cells to free fatty acid with special reference to glucose insensitivity.2002
- Author(s)
  Iizuka K, Nakajima H, et al.
- Journal Title
  
  Biochim. Biophys. Acta 1586
  
  Pages: 23-31
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-14572199
[Journal Article] Metabolic consequence of long-term exposure of pancreatic beta cells to free fatty acid with special reference to glucose insensitivity.2002
- Author(s)
  Iizuka K, Nakajima H, et al.
- Journal Title
  
  Biochim Biophys Acta 1586
  
  Pages: 23-31
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14572199
[Journal Article] Phosphofructokinase deficiency, past, present and future.2002
- Author(s)
  Nakajima H, et al.
- Journal Title
  
  Curr Mol Med 2
  
  Pages: 197-212
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14572199
[Journal Article] Phosphofructokinase deficiency, past, present and future.2002
- Author(s)
  Nakajima H, et al.
- Journal Title
  
  Curr. Mol. Med. 2
  
  Pages: 197-212
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-14572199
[Journal Article] Radiosurgery for acromegaly.2002
- Author(s)
  Saitou Y, Nakajima H, et al.
- Journal Title
  
  Recent Res Devel Endocrino. 3
  
  Pages: 1-10
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14572199

1. HANAFUSA Toshiaki (60164886)

# of Collaborated Projects: 10 results

# of Collaborated Products: 0 results
2. MIYAGAWA Jun-ichiro (00127721)

# of Collaborated Projects: 7 results

# of Collaborated Products: 0 results
3. NAMBA Mitsuyoshi (00183533)

# of Collaborated Projects: 7 results

# of Collaborated Products: 0 results
4. ASAKAWA Hideki (60283785)

# of Collaborated Projects: 4 results

# of Collaborated Products: 0 results
5. KUWAJIMA Masamichi (00205262)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
6. KITAJIMA Koichi (00314310)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
7. KONO Norio (30093412)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
8. YAMASAKI Tomoyuki (00303975)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
9. 嶺尾郁夫 (40243240)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
10. 辻本賀英 (70132735)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
11. 大野昭

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
12. 冨田晃司

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
13. 森脇信

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
14. MIKUNI Tomiko (40332457)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
15. 松沢佑次 (70116101)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
16. 東山繁樹 (60202272)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
17. HAMAGUCHI Tomoya

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
18. 佐々田玲子

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
19. 佐野明彦

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
20. 今川彰久

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
21. 松永隆

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results

NAKAJIMA Hiromu 中島 弘

Research Projects

Research Products

Co-Researchers

Development of molecular investigation technique using the newly identified renal organic acid transporter molecule (hyperuricemia and renal cell carcinoma).Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

筋埋め込み型プラスミドワクチンによる1型糖尿病の遺伝子治療法開発Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

生理活性物質を用いた膵ベータ細胞グルコース不応性(脂肪毒性)の解除に関する研究Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Metabolic consideration on PFK isozymes with reference to the first and the second phase of insulin secretory response from the pancreatic beta cells.Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Principal Investigator

Project Period (FY)

Research Category

Research Institution

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Prevention of type 1 diabetes mellitus by the regulation of pancreas-specific retrovirus expression using the transplacental gene transfer method.Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

膵特異的レトロウイルスによるトランスアクチベーションを介したI型糖尿病発症機序Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Principal Investigator

Project Period (FY)

Research Category

Research Institution

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

I型糖尿病発症におけるレトロウイルスの関与と同遺伝子の発現メカニズムの分析Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Principal Investigator

NAKAJIMA Hiromu 中島弘