UEDA Hiroshi 上田浩

… Alternative Names

上田浩ウエダヒロシ

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Researcher Number	50253779
Other IDs
External Links
Affiliation (Current)	2022: 岐阜大学, 工学部, 教授
Affiliation (based on the past Project Information) *help	2016 – 2022: 岐阜大学, 工学部, 教授 2007 – 2015: Gifu University, 工学部, 准教授 2004 – 2006: 岐阜大学, 工学部, 助教授 2003: Institute for Developmental Research, Aichi Human Service Center, Department of Molecular Neurobiology, Reseach Associate, 神経制御学部, 研究員 1999 – 2002: 愛知県心身障害者コロニー発達障害研究所, 生化学部, 研究員 1993: 大分医科大学, 医学部, 助手
Review Section/Research Field	Principal Investigator Biological pharmacy / Biological pharmacy / Basic Section 47030:Pharmaceutical hygiene and biochemistry-related / Biological Sciences Except Principal Investigator Biological Sciences / Functional biochemistry / Biological pharmacy
Keywords	Principal Investigator Rho / RhoGEF / 三量体G蛋白質 / GPCR / G蛋白質 / Rac / アクチン細胞骨格 / アクチン / 細胞骨格 / 細胞接着 … More / アポトーシス / Rhoキナーゼ / Rhoファミリー低分子量G蛋白質 / 遺伝子制御 / 細胞形態変化 / チロシンリン酸化 / Akt / G protein / SRE / 低分子量G蛋白質 / βγサブユニット / Cdc42 / 細胞伸展 / 百日咳毒素 / リゾフォスファチジン酸 / シグナル伝達 / キナーゼ / リン酸化 / チロシンホスファターゼ / 細胞接着剤 / 細胞死 / インスリン / Rho-kinase / protein tyrosine phosphatase / Apoptosis / cytoskeleton / cell adhesion / actin / RHoGEF / チロシンキナーゼ / 蛋白質間相互作用 / PLEKHG2 / PLEKHG1 / FHL1 / 三量体Gタンパク質 / Src / Rho活性化因子 / 細胞形態 / エクソソーム / PKA / CD81 / 細胞外小胞 / small GTPase / Gタンパク質 / アダプタータンパク質 / タンパク質間相互作用 … More Except Principal Investigator G蛋白質 / 細胞伸展 / Rho / アポトーシス / βγサブユニット / Rac / Cdc42 / リゾホスファチジン酸 / 百日咳毒素 / プロテインキナーゼC / Rhoキナーゼ / カスパーゼ / HeLa細胞 / Akt / チロシンホスファターゼ / RhoGEF / 大腸がん / モノエン脂肪酸 / ホスホリパーゼA_2 / 高オレイン酸サフラワー油 / 脳卒中易発症高血圧ラツト / ICRマウス / ジメチルヒドラジン / サフラワー油 / 接着斑 / アセチルコリン受容体 / RhoA / 神経前駆細胞 / エンドセリン / 細胞接着 / 三量体G蛋白質 / Rhoファミリー低分子量G蛋白質 / アクチン細胞骨格 / 遺伝子制御 / 細胞形態変化 / GPCR / 低分子量G蛋白質 / ムスカリン受容体 / γサブユニット / ストレスファイバー / 神経上皮細胞 / Rhoファミリー / リゾフォスファケジン酸 / 細胞走化性 / リン酸化 / G protein / γ subunit / Stress fibers / Cell spreading / Protein kinase C / Lysophosphatidic acid / Neuroepithelial cells / Rho family / 腸管出血性大腸菌 / シトロバクター・ローデンティウム / III型分泌機構 / アクチン重合 / Rho GTPase / 免疫学 Less

Rho活性化因子に対するタンパク質相互作用原理を用いた新規機能調節分子の創成Principal Investigator
- Principal Investigator
  
  上田浩
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 47030:Pharmaceutical hygiene and biochemistry-related
- Research Institution
  Gifu University
Mechanism of Exosome Production by Heterotrimeric G Protein SignalingPrincipal Investigator
- Principal Investigator
  
  Ueda Hiroshi
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 47030:Pharmaceutical hygiene and biochemistry-related
- Research Institution
  Gifu University
Elucidation of mucosal immunity induction mechanism by microbial adhesion signal and application to mucosal adjuvant development
- Principal Investigator
  
  Sugiyama Tsuyoshi
- Project Period (FY)
  2016 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Biological pharmacy
- Research Institution
  Gihu University of Medical Science
  Gifu Pharmaceutical University
Functional and structural biological analysis of heterotrimeric G protein signal-dependent RhoGEFPrincipal Investigator
- Principal Investigator
  
  UEDA Hiroshi
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Biological pharmacy
- Research Institution
  Gifu University
The physiological roles of the phosphorylation of heterotrimeric G protein signal-dependent RhoGEFsPrincipal Investigator
- Principal Investigator
  
  UEDA Hiroshi
- Project Period (FY)
  2011 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Biological pharmacy
- Research Institution
  Gifu University
二つのGサイクルを結ぶ新規三量体G蛋白質シグナル依存性RhoGEF群の機能解析Principal Investigator
- Principal Investigator
  
  上田浩
- Project Period (FY)
  2008 – 2009
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Gifu University
Identification of novel Gβγ dependent RhoGEF interacting moleculesPrincipal Investigator
- Principal Investigator
  
  UEDA Hiroshi
- Project Period (FY)
  2008 – 2010
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Biological pharmacy
- Research Institution
  Gifu University
三量体G蛋白質シグナルにより制御されるRho活性化因子の網羅的探索とその調節機構Principal Investigator
- Principal Investigator
  
  上田浩, 浅野富子
- Project Period (FY)
  2006 – 2007
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Gifu University
  Institute for Developmental Research, Aichi Human Service Center
Studies on regulation of cytoskeleton by novel RhoGEF activated by G protein signalingPrincipal Investigator
- Principal Investigator
  
  UEDA Hiroshi
- Project Period (FY)
  2004 – 2005
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Biological pharmacy
- Research Institution
  Gifu University
三量体GTP結合蛋白質による細胞接着・運動の制御機構
- Principal Investigator
  
  浅野富子
- Project Period (FY)
  2003
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Institute for Developmental Research, Aichi Human Service Center
三量体GTP結合蛋白質による細胞接着・運動の制御機構
- Principal Investigator
  
  浅野富子
- Project Period (FY)
  2002
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Institute for Developmental Research, Aichi Human Service Center
Studies on regulation of cytoskeleton by heterotrimeric GTP-binding protein signaling.Principal Investigator
- Principal Investigator
  
  UEDA Hiroshi
- Project Period (FY)
  2002 – 2003
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Biological pharmacy
- Research Institution
  Institute for Developmental Research, Aichi Human Service Center
三量体GTP結合蛋白質による細胞接着・運動の制御機構の解明
- Principal Investigator
  
  浅野富子
- Project Period (FY)
  2001
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas (C)
- Review Section
  
  Biological Sciences
- Research Institution
  Institute for Developmental Research, Aichi Human Service Center
三量体GTP結合蛋白質βγサブユニットによる細胞接着・運動の制御機構の解明
- Principal Investigator
  
  ASANO Tomiko
- Project Period (FY)
  2000
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas (C)
- Review Section
  
  Biological Sciences
- Research Institution
  Institute for Developmental Research, Aichi Human Service Center
三量体G蛋白質βγサブユニットによるアクチン細胞骨格と細胞接着の制御機構の解明Principal Investigator
- Principal Investigator
  
  上田浩
- Project Period (FY)
  2000 – 2001
- Research Category
  
  Grant-in-Aid for Encouragement of Young Scientists (A)
- Research Field
  
  Biological pharmacy
- Research Institution
  Institute for Developmental Research, Aichi Human Service Center
Studies on various γ subunits of heterotrimeric GTP-binding proteins
- Principal Investigator
  
  ASANO Tomiko
- Project Period (FY)
  1999 – 2000
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Functional biochemistry
- Research Institution
  Institute for Developmental Research, Aichi Human Service Center
不飽和脂肪酸による循環系疾患およびガンの抑制機構
- Principal Investigator
  
  竹下正純
- Project Period (FY)
  1993
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  大分医科大学

[Journal Article] Impaired Function of PLEKHG2, a Rho-Guanine Nucleotide-Exchange Factor, Disrupts Corticogenesis in Neurodevelopmental Phenotypes2022
- Author(s)
  Nishikawa M, Ito H, Tabata H, Ueda H, Nagata KI.
- Journal Title
  
  Cells
  
  Volume: 16 Pages: 696-696
- DOI
  10.3390/cells11040696
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K07043, KAKENHI-PROJECT-20K22888, KAKENHI-PROJECT-19K07059
[Journal Article] The Rho guanine nucleotide exchange factor PLEKHG1 is activated by interaction with and phosphorylation by Src family kinase member FYN.2022
- Author(s)
  Nakano S, Nishikawa M, Kobayashi T, Harlin EW, Ito T, Sato K, Sugiyama T, Yamakawa H, Nagase T, Ueda H.
- Journal Title
  
  J Biol Chem
  
  Volume: 298 Pages: 101579-101579
- DOI
  10.1016/j.jbc.2022.101579
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K07043
[Journal Article] Specific inhibition of oncogenic RAS using cell-permeable RAS-binding domains2021
- Author(s)
  Nomura, T.K., Heishima, K., Sugito, N., Sugawara, R., Ueda, H., Akao, Y. and Honda, R.
- Journal Title
  
  Cell Chemical Biology
  
  Volume: -
- DOI
  10.1016/j.chembiol.2021.04.013
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K07043, KAKENHI-PROJECT-19K16828
[Journal Article] Petasin potently inhibits mitochondrial complex I-based metabolism that supports tumor growth and metastasis.2021
- Author(s)
  Heishima K, Sugito N, Soga T, Nishikawa M, Ito Y, Honda R, Kuranaga Y, Sakai H, Ito R, Nakagawa T, Ueda H, Akao Y
- Journal Title
  
  J Clin Invest
  
  Volume: 131
- DOI
  10.1172/jci139933
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K07043
[Journal Article] Structural and functional characterization of fast-cycling RhoF GTPase.2019
- Author(s)
  Sugawara R, Ueda H, Honda R.
- Journal Title
  
  Biochem Biophys Res Commun.
  
  Volume: 513(2) Pages: 522-527
- DOI
  10.1016/j.bbrc.2019.04.018
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K07043
[Journal Article] DBS is activated by EPHB2/SRC signaling-mediated tyrosine phosphorylation in HEK293 cells.2019
- Author(s)
  Nakano Shun、Nishikawa Masashi、Asaoka Rina、Ishikawa Natsuko、Ohwaki Chisato、Sato Katsuya、Nagaoka Hitoshi、Yamakawa Hisashi、Nagase Takahiro、Ueda Hiroshi
- Journal Title
  
  Mol Cell Biochem.
  
  Volume: 459 Pages: 83-93
- DOI
  10.1007/s11010-019-03552-5
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18J13111, KAKENHI-PROJECT-19K07043
[Journal Article] The interaction between PLEKHG2 and ABL1 suppresses cell growth via the NF-κB signaling pathway in HEK293 cells.2019
- Author(s)
  Nishikawa Masashi、Nakano Shun、Nakao Hiromu、Sato Katsuya、Sugiyama Tsuyoshi、Akao Yukihiro、Nagaoka Hitoshi、Yamakawa Hisashi、Nagase Takahiro、Ueda Hiroshi
- Journal Title
  
  Cell Signal.
  
  Volume: 61 Pages: 93-107
- DOI
  10.1016/j.cellsig.2019.04.016
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16K08241, KAKENHI-PROJECT-18K15045, KAKENHI-PROJECT-18J13111, KAKENHI-PROJECT-19K07043
[Journal Article] Specific activation of PLEKHG2-induced serum response element-dependent gene transcription by four-and-a-half LIM domains (FHL) 1, but not FHL2 or FHL32017
- Author(s)
  Masashi Nishikawa, Katsuya Sato, Shun Nakano, Hisashi Yamakawa, Takahiro Nagase, Hiroshi Ueda
- Journal Title
  
  Small GTPases
  
  Volume: 10 Pages: 1-6
- DOI
  10.1080/21541248.2017.1327838
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15K07927, KAKENHI-PROJECT-15K19005
[Journal Article] Heterotrimeric G protein Gαs subunit attenuates PLEKHG2, a Rho family-specific guanine nucleotide exchange factor, by direct interaction.2017
- Author(s)
  Sugiyama K, Tago K, Matsushita S, Nishikawa M, Sato K, Muto Y, Nagase T, Ueda H
- Journal Title
  
  Cellular Signalling
  
  Volume: 32 Pages: 115-123
- DOI
  10.1016/j.cellsig.2017.01.022
- Peer Reviewed / Acknowledgement Compliant / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26440062, KAKENHI-PROJECT-15K07927, KAKENHI-PROJECT-15K19005, KAKENHI-PROJECT-17K07343
[Journal Article] Four-and-a-Half LIM Domains 1 (FHL1) Protein Interacts with the Rho Guanine Nucleotide Exchange Factor PLEKHG2/FLJ00018 and Regulates Cell Morphogenesis2016
- Author(s)
  Sato, K., Kimura, M., Sugiyama, K., Nishikawa, M., Okano, Y., Nagaoka, H., Nagase, T., Kitade, Y., and Ueda, H.
- Journal Title
  
  J. Biol. Chem.
  
  Volume: 291 Pages: 25227-25238
- DOI
  10.1074/jbc.m116.759571
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-26460363, KAKENHI-PROJECT-15K07927, KAKENHI-PROJECT-15K19005
[Journal Article] PKM1 is involved in resistance to anti-cancer drugs.2016
- Author(s)
  Taniguchi K, Sakai M, Sugito N, Kuranaga Y, Kumazaki M, Shinohara H, Ueda H, Futamura M, Yoshida K, Uchiyama K, Akao Y.
- Journal Title
  
  Biochem Biophys Res Commun.
  
  Volume: 0000 Pages: 0000-0000
- DOI
  10.1016/j.bbrc.2016.03.074
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-15K07927, KAKENHI-PROJECT-16J08131, KAKENHI-PROJECT-15K10120
[Journal Article] 三量体G蛋白質により調節されるRhoファミリー低分子量G蛋白質特異的グアニンヌクレオチド交換因子2016
- Author(s)
  上田浩
- Journal Title
  
  生化学
  
  Volume: 88 Pages: 416-418
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15K07927
[Journal Article] PTBP1-associated microRNA-1 and -133b suppress the Warburg effect in colorectal tumors.2016
- Author(s)
  Taniguchi K, Sakai M, Sugito N, Kumazaki M, Shinohara H, Yamada N, Nakayama T, Ueda H, Nakagawa Y, Ito Y, Futamura M, Uno B, Otsuki Y, Yoshida K, Uchiyama K, Akao Y.
- Journal Title
  
  Oncotarget.
  
  Volume: 0000 Pages: 0000-0000
- DOI
  10.18632/oncotarget.8005
- NAID
  40021358229
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-15K07927, KAKENHI-PROJECT-16J08131, KAKENHI-PROJECT-15K10120, KAKENHI-PROJECT-16K10482
[Journal Article] Adaptive evolution of formyl peptide receptors in mammals.2015
- Author(s)
  Muto Y, Guindon S, Umemura T, Kőhidai L, Ueda H
- Journal Title
  
  J Mol Evol.
  
  Volume: 80 Pages: 130-141
- DOI
  10.1111/scd.12105
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23590073
[Journal Article] Adaptive evolution of formyl peptide receptors in mammals.2015
- Author(s)
  Muto Y, Guindon S, Umemura T, Kohidai L, Ueda H.
- Journal Title
  
  J Mol Evol
  
  Volume: 80 Pages: 130-141
- DOI
  10.1007/s00239-015-9666-z
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15K07927
[Journal Article] Understanding of tolerance in TRAIL-induced apoptosis and cancelation of its machinery by α-mangostin, a xanthone derivative.2015
- Author(s)
  Kumazaki M, Shinohara H, Taniguchi K, Ueda H, Nishi M, Ryo A, Akao Y.
- Journal Title
  
  Oncotarget
  
  Volume: 6 Pages: 25828-25842
- DOI
  10.18632/oncotarget.4558
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15K07927
[Journal Article] Involvement of cdc42/Rho kinase in apoA-I-mediated cholesterol efflux through interaction between cytosolic lipid-protein particles and microtubules in rat astrocytes2014
- Author(s)
  11. Kheirollah A., Nagayasu Y., Ueda H., Yokoyama S. Michikawa M. and Ito J.
- Journal Title
  
  J Neurosci Res
  
  Volume: 92 Pages: 455-463
- DOI
  10.1002/jnr.23324
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23590073, KAKENHI-PROJECT-24614018, KAKENHI-PROJECT-25461375
[Journal Article] PLEKHG2/FLJ00018, a Rho family-specific guanine nucleotide exchange factor, is tyrosine phosphorylated via the EphB2/cSrc signaling pathway.2014
- Author(s)
  12. Sato K., Suzuki T., Yamaguchi Y., Kitade Y., Nagase T. and Ueda H.
- Journal Title
  
  Cell. Signal.
  
  Volume: 26 Pages: 691-696
- DOI
  10.1016/j.cellsig.2013.12.006
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23590073
[Journal Article] Threonine 680 phosphorylation of FLJ00018/PLEKHG2, a Rho family-specific guanine nucleotide exchange factor, by epidermal growth factor receptor signaling regulates cell morphology of Neuro-2a cells.2014
- Author(s)
  13. Sato K., Sugiyama T., Nagase T., Kitade Y. and Ueda H.
- Journal Title
  
  J. Biol. Chem.
  
  Volume: 289 Pages: 10045-10056
- DOI
  10.1074/jbc.m113.521880
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23590073
[Journal Article] Identification of a Rho family specific guanine nucleotide exchange factor FLJ00018, as a novel actin-binding protein.2013
- Author(s)
  Sato, K., Handa, H., Kimura, M., Okano,Y., Nagaoka, H., Nagase, T., Sugiyama,T., Kitade, Y., and Ueda, H.
- Journal Title
  
  Cell Signal
  
  Volume: 25 Pages: 41-49
- DOI
  10.1016/j.cellsig.2012.09.015
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590331, KAKENHI-PROJECT-23590073, KAKENHI-PROJECT-23659151, KAKENHI-PUBLICLY-23118513
[Journal Article] The Importance of Interaction with Membrane Lipids through the Pleckstrin Homology Domain of the Guanine Nucleotide Exchange Factor for Rho Family Small Guanosine Triphosphatase, FLJ000182013
- Author(s)
  10. Kimura S., Sato K., Banno Y., Nagase T. and Ueda H.
- Journal Title
  
  Biol. Pharm. Bull.
  
  Volume: 36 Issue: 7 Pages: 1204-1207
- DOI
  10.1248/bpb.b12-00520
- NAID
  130003361463
- ISSN
  0918-6158, 1347-5215
- Language
  English
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23590073
[Journal Article] PMA induces GCMa phosphorylation and alters its stability via the PKC- and ERK-dependent pathway.2012
- Author(s)
  Yasui Y., Yamada K., Takahashi S., Sugiura-Ogasawara M., Sato K., Miyazawa D., Sugiyama T., Kitade Y., and Ueda H.
- Journal Title
  
  Biochem. Biophys. Res. Commun.
  
  Volume: 417 Pages: 1127-1132
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23590073
[Journal Article] Mechanism of inhibition of lipopolysaccharide-induced interferon-β production by 2-aminopurine.2012
- Author(s)
  Sugiyama T., Gotou T., Moriyama K., Nodoka Kajiura K., Hasegawa T., Tomida J., Takahashi K., Komatsu T., Ueda H., Sato K., Tokoro S., Neri P. and Mori H.
- Journal Title
  
  Mol. Immun.
  
  Volume: 52 Pages: 299-304
- DOI
  10.1016/j.molimm.2012.06.008
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23590073
[Journal Article] PMA-induced GCMa phosphorylation stimulates its transcriptional activity and degradation.2012
- Author(s)
  Yasui Y., Miyazawa D., Hiroshi Ueda H., Sato K., Kitade Y. and Yamada K.
- Journal Title
  
  Biomed. Res.
  
  Volume: 33 Pages: 217-224
- NAID
  130004470824
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23590073
[Journal Article] Gs and Gq signalings regulate hPEM-2-induced cell responses in Neuro-2a cells.2011
- Author(s)
  Nagae R., Sato K., Yasui Y., Banno Y., Nagase T. and Ueda H.
- Journal Title
  
  Biochem. Biophys. Res. Commun.
  
  Volume: 415 Pages: 168-204
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23590073
[Journal Article] TRPM1 : A vertebrate TRP channel responsible for retinal ON bipolar function.2010
- Author(s)
  Koike C., Numata T., Ueda H., Mori Y., Furukawa T.
- Journal Title
  
  Cell Caluciuru 48
  
  Pages: 95-101
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590055
[Journal Article] TRPM1 is a component of the retinal ON bipolar cell transduction channel in the mGluR6 cascade.2010
- Author(s)
  Koike C., Obara T., Uriu Y., Numata T., Sanuki R., Miyata K., Koyasu T., Ueno S., Funabiki K., Tani A., Ueda H., Kondo M., Mori Y., Tachibana M., Furukawa T.
- Journal Title
  
  Proc.Natl.Acad.Sci.U.S.A. 107(1)
  
  Pages: 332-337
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590055
[Journal Article] Sphingosine kinase isoforms regulate oxaliplatin sensitivity of human colon cancer cells through ceramide accumulation and AKT activation.2009
- Author(s)
  Nemoto S., Nakamura M., Osawa Y., Kono S., Itoh Y., Okano Y., Murate T., Hara A., Ueda H., Nozawa Y., Banno Y.
- Journal Title
  
  J Biol.Chem. 284
  
  Pages: 10422-10432
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590055
[Journal Article] Hetcrotrimeric G Protein βγ Subunits Stimulate FLJ00018,a Guanine Nucleotide Exchange Factor for Racl and Cdc422008
- Author(s)
  Ueda H., et. al.
- Journal Title
  
  Journal of Biological Chemistry 283
  
  Pages: 1946-1953
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18057030
[Journal Article] Gα_<q/11> signaling induces apoptosis through two pathways involving reduction of Akt phosphorylation and activation of RhoA in HeLa cells2004
- Author(s)
  Ueda, H., et al.
- Journal Title
  
  Experimental Cell Research 298・1
  
  Pages: 207-217
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16590079
[Journal Article] Gαq/11 signaling induces apoptosis through two pathways involving reduction of Akt phosphorylation and activation of RhoA in Hela cells.2004
- Author(s)
  Ueda, H.
- Journal Title
  
  Exp.Cell Res. 298-1
  
  Pages: 207-217
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16590079
[Presentation] アダプタータンパク質NCK2によるSH3ドメインを介したRho活性化因子PLEKHG1の活性制御2021
- Author(s)
  井藤拓哉、後藤未沙紀、中野駿、西川将司、山川央、長瀬隆弘、上田浩
- Organizer
  日本薬学会　第141年会
- Data Source
  KAKENHI-PROJECT-19K07043
[Presentation] 非受容体型チロシンキナーゼ FYNによる Rho活性化因子 PLEKHG1の活性制御2020
- Author(s)
  中野駿、西川将司、小林知世、杉山剛志、山川央、長瀬隆弘、上田浩
- Organizer
  日本生化学会第93回日本生化学会大会
- Data Source
  KAKENHI-PROJECT-19K07043
[Presentation] SH3ドメインを介したアダプター蛋白質NCK2によるRho活性化因子PLEKHG1の機能制御2019
- Author(s)
  後藤美沙紀、西川将司、中野駿、山川央、長瀬隆弘、上田浩
- Organizer
  第42回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-19K07043
[Presentation] 嗅覚受容体における新規短鎖脂肪酸受容体の同定2019
- Author(s)
  八橋茉利奈、吉田泰徳、今枝孝夫、西川将司、中野駿、喜多村徳昭、池田将、榊原清美、本山ユミ、長瀬隆弘、上田浩
- Organizer
  第42回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-19K07043
[Presentation] 三量体G蛋白質GiシグナルによるRho活性化因子PLEKHG1の活性制御2019
- Author(s)
  西川将司、中野駿、山川央、長瀬隆弘、上田浩
- Organizer
  第42回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-19K07043
[Presentation] KIAA0599 augments TRIF- and Myd88-dependent TLR signaling2018
- Author(s)
  Tsuyoshi Sugiyama, Kanna Nakao, Ryo Hayami, Takuya Hasegawa, Keita Takahashi, Naoki Inoue, Takahiro Nagase, Hiroshi Ueda
- Organizer
  Joint Meeting of the Society for Leukocyte Biology & the International Endotoxin and Innate Immunity Society
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K08241
[Presentation] 非受容体型チロシンキナーゼABL1によるRho活性化因子PLEKHG2の活性制御2017
- Author(s)
  西川将司、中尾拡、中野駿、石川奈津子、大脇千智、山川央、長瀬隆弘、上田浩
- Organizer
  第81回日本生化学会中部支部　例会・シンポジウム
- Data Source
  KAKENHI-PROJECT-15K07927
[Presentation] FYNによるRho活性化因子PLEKHG1の活性制御機構2017
- Author(s)
  小林知世、西川将司、中野駿、石川奈津子、大脇千智、貝増聖嘉、杉山剛志、山川央、長瀬隆弘、上田浩
- Organizer
  2017年度生命科学系学会合同年次大会
- Data Source
  KAKENHI-PROJECT-15K07927
[Presentation] 三量体G蛋白質シグナルによる低分子量G蛋白質RhoF活性抑制機構2017
- Author(s)
  石川奈津子、大脇千智、西川将司、中野駿、杉山剛志、山川央、長瀬隆弘、上田浩
- Organizer
  日本病院薬剤師会東海ブロック・日本薬学会東海支部合同学術大会2017
- Data Source
  KAKENHI-PROJECT-15K07927
[Presentation] EPHB2/SRCを介したRho活性化因子Dbsのリン酸化2017
- Author(s)
  中野駿、西川将司, 浅岡里奈、田代圭、石川奈津子、大脇千智、佐藤克哉、山川央、長瀬隆弘、上田浩
- Organizer
  2017年度生命科学系学会合同年次大会
- Data Source
  KAKENHI-PROJECT-15K07927
[Presentation] Rhoグアニンヌクレオチド交換因子PLEKHG3によるTRIF依存的シグナル増強作用2017
- Author(s)
  中尾莞奈、早水良、秋元奈央、長谷川拓也、高橋圭太、井上直樹、長瀬隆弘、上田浩、杉山剛志
- Organizer
  第54 回日本細菌学会中部支部総会
- Data Source
  KAKENHI-PROJECT-16K08241
[Presentation] p21-activated kinase 1によるRho活性化因子PLEKHG1の抑制機構2017
- Author(s)
  大脇千智、石川奈津子、西川将司、中野駿、山川央、長瀬隆弘、上田浩
- Organizer
  日本病院薬剤師会東海ブロック・日本薬学会東海支部合同学術大会2017
- Data Source
  KAKENHI-PROJECT-15K07927
[Presentation] 非受容体型チロシンキナーゼABL1によるRho活性化因子PLEKHG2の活性制御と核内移行2017
- Author(s)
  西川将司、中野駿、中尾拡、佐藤克哉、山川央、長瀬隆弘、上田浩
- Organizer
  2017年度生命科学系学会合同年次大会
- Data Source
  KAKENHI-PROJECT-15K07927
[Presentation] EphB2/cSrcを介したチロシンリン酸化によるRho活性化因子Dbsの活性化機構2017
- Author(s)
  中野駿、浅岡里奈、西川将司、石川奈津子、大脇千智、山川央、長瀬隆弘、上田浩
- Organizer
  第81回日本生化学会中部支部　例会・シンポジウム
- Data Source
  KAKENHI-PROJECT-15K07927
[Presentation] 腸管上皮細胞におけるRho GTPase活性化のToll様受容体シグナルへの影響2016
- Author(s)
  矢端文彦、中尾莞奈、早水良、田中秀幸、児玉雄大、高橋圭太、井上直樹、長瀬隆弘、上田浩、杉山剛志
- Organizer
  日本病院薬剤師会東海ブロック日本薬学会東海支部合同学術大会2016
- Place of Presentation
  岐阜市長良川国際会議場
- Data Source
  KAKENHI-PROJECT-15K07927
[Presentation] 三量体G蛋白質によるRho活性化因子PLEKHG1の活性制御2016
- Author(s)
  西川将司、杉山和恵、佐藤克哉、長瀬隆弘、上田浩
- Organizer
  日本病院薬剤師会東海ブロック日本薬学会東海支部合同学術大会2016
- Place of Presentation
  岐阜市長良川国際会議場
- Data Source
  KAKENHI-PROJECT-15K07927
[Presentation] SrcファミリーチロシンキナーゼFynによるPLEKHG1のチロシンリン酸化と活性制御2016
- Author(s)
  小林知世、石川奈津子、大脇千智、貝増聖嘉、西川将司、長瀬隆弘、上田浩
- Organizer
  日本病院薬剤師会東海ブロック日本薬学会東海支部合同学術大会2016
- Place of Presentation
  岐阜市長良川国際会議場
- Data Source
  KAKENHI-PROJECT-15K07927
[Presentation] 三量体G蛋白質によるRho活性化因子PLEKHG1の活性制御2016
- Author(s)
  西川将司 , 杉山和恵 , 佐藤克哉 , 山川央 , 長瀬隆弘 , 上田浩
- Organizer
  第３９回日本分子生物学会年会
- Place of Presentation
  横浜市　パシフィコ横浜
- Year and Date
  2016-11-30
- Data Source
  KAKENHI-PROJECT-15K07927
[Presentation] 腸管上皮細胞におけるRho GTPase活性化のToll様受容体シグナルへの影響2016
- Author(s)
  矢端文彦、中尾莞奈、早水良、田中秀幸、児玉雄大、高橋圭太、井上直樹、長瀬隆弘、上田浩、杉山剛志
- Organizer
  日本病院薬剤師会東海ブロック・日本薬学会東海支部合同学術大会2016
- Place of Presentation
  岐阜
- Year and Date
  2016-10-30
- Data Source
  KAKENHI-PROJECT-16K08241
[Presentation] 三量体G蛋白質によるRho活性化因子PLEKHG3の活性制御2016
- Author(s)
  中野駿、西川将司、長瀬隆弘、上田浩
- Organizer
  日本病院薬剤師会東海ブロック日本薬学会東海支部合同学術大会2016
- Place of Presentation
  岐阜市長良川国際会議場
- Data Source
  KAKENHI-PROJECT-15K07927
[Presentation] ARHGEF15 augments TRIF-dependent pathway of TLR signaling via enhancing the phosphorylation of IRF-32016
- Author(s)
  Sugiyama T, Hasegawa T, Takahashi K, Inoue N., Nagase T., Ueda H.
- Organizer
  14th Biennial Meeting of International Endotoxin and Innate Immunity Society
- Place of Presentation
  ドイツ・ハンブルグ
- Year and Date
  2016-09-22
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K08241
[Presentation] 新規短鎖脂肪酸特異的受容体としての嗅覚受容体の同定と解析2016
- Author(s)
  吉田泰徳、本山ユミ、榊原清美、今枝孝夫、喜多村徳昭、柴田綾、池田将、長瀬隆弘、上田浩
- Organizer
  日本病院薬剤師会東海ブロック日本薬学会東海支部合同学術大会2016
- Place of Presentation
  岐阜市長良川国際会議場
- Data Source
  KAKENHI-PROJECT-15K07927
[Presentation] Sec14 domain-Spectrin repeat 含有Rho活性化因子群の三量体G蛋白質との相互作用とその活性化2015
- Author(s)
  板津美穂、杉山和恵、長瀬隆弘、上田浩
- Organizer
  日本病院薬剤師会東海ブロック・日本薬学会東海支部合同学術大会２０１５
- Place of Presentation
  名古屋市金城学院大学薬学部
- Year and Date
  2015-11-01
- Data Source
  KAKENHI-PROJECT-15K07927
[Presentation] cSrcによるRho活性化因子Dbsのチロシンリン酸化と活性制御2015
- Author(s)
  浅岡里奈、田代圭、中野駿、吉田泰徳、杉山和恵、長瀬隆弘、上田浩
- Organizer
  日本病院薬剤師会東海ブロック・日本薬学会東海支部合同学術大会２０１５
- Place of Presentation
  名古屋市金城学院大学薬学部
- Year and Date
  2015-11-01
- Data Source
  KAKENHI-PROJECT-15K07927
[Presentation] Rho活性化因子PLEKHG2の ABL1及びcSrcとの相互作用とその生理機能2015
- Author(s)
  中尾拡、杉山和恵、長瀬隆弘、上田浩
- Organizer
  日本病院薬剤師会東海ブロック・日本薬学会東海支部合同学術大会２０１５
- Place of Presentation
  名古屋市金城学院大学薬学部
- Year and Date
  2015-11-01
- Data Source
  KAKENHI-PROJECT-15K07927
[Presentation] Rho特異的活性化因子PLEKHG2のGasとの相互作用による制御機構2015
- Author(s)
  杉山和恵、多胡憲治、武藤吉徳、長瀬隆弘、上田　浩
- Organizer
  BMB2015
- Place of Presentation
  神戸市ポートアイランド
- Year and Date
  2015-12-01
- Data Source
  KAKENHI-PROJECT-15K07927
[Presentation] PLEKHG2/FLJ00018のEphB2/Srcシグナルによるリン酸化とSH2ドメイン含有蛋白質との相互作用2014
- Author(s)
  佐藤克哉, 鈴木敬浩, 山口佳洋, 北出幸夫, 長瀬隆弘, 上田浩
- Organizer
  第８７回日本生化学会大会
- Place of Presentation
  京都
- Year and Date
  2014-10-17
- Data Source
  KAKENHI-PROJECT-23590073
[Presentation] Rhoファミリーグアニンヌクレオチド交換因子FLJ00018はToll様受容体2からMyD88依存的シグナルを増強する2012
- Author(s)
  杉山剛志、高橋圭太、上田浩、佐藤克哉、長瀬隆弘、森裕志
- Organizer
  第８５回日本生化学会大会
- Place of Presentation
  福岡国際会議場
- Data Source
  KAKENHI-PROJECT-23590073
[Presentation] Rho特異的活性化因子FLJ00018とアクチンの相互作用によるFLJ00018の機能制御2012
- Author(s)
  佐藤克哉、半田浩章、木村正志、岡野幸雄、長岡仁、長瀬隆弘、杉山剛志、北出幸夫、上田浩
- Organizer
  第８５回日本生化学会大会
- Place of Presentation
  福岡国際会議場
- Data Source
  KAKENHI-PROJECT-23590073
[Presentation] Rhoファミリー低分子量G蛋白質活性化因子GiRhoGEFとGi2の相互作用による活性制御2011
- Author(s)
  上田浩、佐藤克哉、加藤久司、長瀬隆弘
- Organizer
  第84回日本生化学会大会合同大会
- Place of Presentation
  神戸
- Data Source
  KAKENHI-PROJECT-23590073
[Presentation] Gβγ-RhoGEF,FLJ00018のEGFRによるリン酸化とその細胞機能.2011
- Author(s)
  佐藤克哉、北出幸夫、長瀬隆弘、上田浩
- Organizer
  第84回日本生化学会大会合同大会
- Place of Presentation
  神戸
- Data Source
  KAKENHI-PROJECT-23590073
[Presentation] Gβγと相互作用するRhoGEF, GBGEF3の活性制御機構(ポスター発表)2010
- Author(s)
  佐藤克哉、柴田裕貴、長瀬隆弘、上田浩
- Organizer
  第33回日本分子生物学学会年会第83回日本生化学会大会合同大会BMB2010
- Place of Presentation
  神戸
- Data Source
  KAKENHI-PROJECT-20590055
[Presentation] 新規GPCRシグナル依存性Rho活性化因子の細胞機能における役割(口頭発表)2010
- Author(s)
  上田浩
- Organizer
  先端創薬医療シンポジウム
- Place of Presentation
  岐阜
- Data Source
  KAKENHI-PROJECT-20590055
[Presentation] 新規βγ依存的RhoA活性化因子のSrcによる活性制御(ポスター発表)2009
- Author(s)
  高野英悟、佐藤克哉、加藤久司、長瀬隆弘、上田浩
- Organizer
  第82回日本生化学会大会合同大会
- Place of Presentation
  神戸
- Data Source
  KAKENHI-PROJECT-20590055
[Presentation] GiによるRhoファミリー低分子G蛋白質活性化因子の活性制御(ボスター発表)2009
- Author(s)
  加藤久司、佐藤克哉、高野英悟、長瀬隆弘、上田浩
- Organizer
  第82回日本生化学会大会合同大会
- Place of Presentation
  神戸
- Data Source
  KAKENHI-PROJECT-20590055
[Presentation] Rho活性化因子FLJOOO18のEGF受容体transactivationを介した活性化機構(ポスター発表)2009
- Author(s)
  佐藤克哉、加藤久司、高野英悟、長瀬隆弘、上田浩
- Organizer
  第82回日本生化学会大会合同大会
- Place of Presentation
  神戸
- Data Source
  KAKENHI-PROJECT-20590055
[Presentation] 三量体G蛋白質βγ依存性RhoGEF, FLJ00018のPDZドメイン結合モチーフを介する活性制御の検討2008
- Author(s)
  上田浩, その, 他
- Organizer
  第31回日本分子生物学会年会・第81回日本生化学会大会合同大会
- Place of Presentation
  神戸ポートアイランド
- Year and Date
  2008-12-09
- Data Source
  KAKENHI-PROJECT-20590055
[Presentation] 三量体G蛋白質βγ依存性RhoGEF,FLJ00018のPDZドメイン結合モチーフを介する活性制御の検討(ポスター発表)2008
- Author(s)
  上田浩、中峰康揮、夏目陽子、佐藤克哉、長瀬隆弘、小原収、吉田敏
- Organizer
  第31回日本分子生物学学会年会第81回日本生化学会大会合同大会BMB2008
- Place of Presentation
  神戸
- Data Source
  KAKENHI-PROJECT-20590055
[Presentation] Heterotrimeric G Protein βγ Subunits Stimulate FLJ000l8.a Guanine Nucleotide Exchange Factor for Racl2007
- Author(s)
  上田浩その他
- Organizer
  第30回日本分子生物学会年会・第80回日本生化学会大会合同大会
- Place of Presentation
  パシフィコ横浜
- Year and Date
  2007-12-13
- Data Source
  KAKENHI-PROJECT-18057030
[Presentation] Rho活性化因子FLJ00018とFour and a half LIM domain 1との相互作用
- Author(s)
  佐藤克哉、木村正志、長岡仁、長瀬隆弘、北出幸夫、上田浩
- Organizer
  第86回日本生化学会大会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-23590073
[Presentation] Rho特異的活性化因子PLEKHG2のGs/PKA経路による制御
- Author(s)
  上田浩、佐藤克哉、武藤吉徳、長瀬隆弘
- Organizer
  第86回日本生化学会大会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-23590073

1. ASANO Tomiko (70100154)

# of Collaborated Projects: 6 results

# of Collaborated Products: 0 results
2. 森下理香

# of Collaborated Projects: 5 results

# of Collaborated Products: 0 results
3. BANNO Yoshiko (50116852)

# of Collaborated Projects: 2 results

# of Collaborated Products: 1 results
4. AKAO Yukihiro (00222505)

# of Collaborated Projects: 2 results

# of Collaborated Products: 5 results
5. Sugiyama Tsuyoshi (70268001)

# of Collaborated Projects: 1 results

# of Collaborated Products: 5 results
6. 竹下正純 (50019551)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. 吉田敏 (50158440)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. 加藤善一郎 (90303502)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. 高橋圭太 (50634929)

# of Collaborated Projects: 1 results

# of Collaborated Products: 4 results
10. RO Ei

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
11. UCHIYAMA Kazuhisa

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
12. TAGO Kenji

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
13. ITO Yuko

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
14. 本田諒

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
15. 木村正志

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
16. 佐藤克哉

# of Collaborated Projects: 0 results

# of Collaborated Products: 4 results
17. 長岡仁

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
18. 岡野幸雄

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
19. 西川将司

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
20. 伊東秀記

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
21. 横山信治

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
22. 道川誠

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
23. 谷口高平

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results

UEDA Hiroshi 上田 浩

上田 浩 ウエダ ヒロシ

Research Projects

Research Products

Co-Researchers

Rho活性化因子に対するタンパク質相互作用原理を用いた新規機能調節分子の創成Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Mechanism of Exosome Production by Heterotrimeric G Protein SignalingPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Elucidation of mucosal immunity induction mechanism by microbial adhesion signal and application to mucosal adjuvant development

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Functional and structural biological analysis of heterotrimeric G protein signal-dependent RhoGEFPrincipal Investigator

Principal Investigator

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The physiological roles of the phosphorylation of heterotrimeric G protein signal-dependent RhoGEFsPrincipal Investigator

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二つのGサイクルを結ぶ新規三量体G蛋白質シグナル依存性RhoGEF群の機能解析Principal Investigator

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Identification of novel Gβγ dependent RhoGEF interacting moleculesPrincipal Investigator

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三量体G蛋白質シグナルにより制御されるRho活性化因子の網羅的探索とその調節機構Principal Investigator

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Studies on regulation of cytoskeleton by novel RhoGEF activated by G protein signalingPrincipal Investigator

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三量体GTP結合蛋白質による細胞接着・運動の制御機構

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三量体GTP結合蛋白質による細胞接着・運動の制御機構

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Studies on regulation of cytoskeleton by heterotrimeric GTP-binding protein signaling.Principal Investigator

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三量体GTP結合蛋白質による細胞接着・運動の制御機構の解明

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UEDA Hiroshi 上田浩

上田浩ウエダヒロシ