IN Yasuko 尹康子

… Alternative Names

いん康子インヤスコ

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Researcher Number	50257896
Other IDs
External Links
Affiliation (Current)	2022: 大阪医科薬科大学, 薬学部, 准教授
Affiliation (based on the past Project Information) *help	2012: 大阪薬科大学, 薬学部, 准教授 2009 – 2011: 大阪薬科大学, 薬学部, 講師 2006 – 2007: 大阪薬科大学, 薬学部, 助教 2005: 大阪薬科大学, 薬学部, 助手 2001 – 2003: 大阪薬科大学, 薬学部, 助手 1993 – 1998: 大阪薬科大学, 薬学部, 助手
Review Section/Research Field	Principal Investigator Physical pharmacy Except Principal Investigator Drug development chemistry / 医薬分子機能学 / Chemistry related to living body / Biophysics / Physical pharmacy
Keywords	Principal Investigator X線結晶構造解析 / NMR溶液構造解析 / 細胞毒性 / 環状ペプチド / C2対称立体コンフォメーション / endomorphin-2 / NMR / C-terminal amidation / X-ray analysis / crystal structure … More / patellamide A / ascidiacyclamide / cyclic peptide / X-Ray crystal analysis / moleailar conformation / 活性型コンフォメーション / C-末端アミド化 / 分子動力学計算 / 溶液構造 / オピオイドペプチド / リン脂質 / X-線結晶構造解析 / molecular conformation / solution conformation / molecular modeling calculation / dipeptides / solution structure / molecular dynamics simulation … More Except Principal Investigator タウ蛋白質 / NMR / 微小管結合ドメイン / 阻害剤 / 構造解析 / 重合抑制 / 抗体 / 抑制機構 / X-ray analysis / PNA / PEPTIDE / STRUCTURE / INTERACTION / HETEROMOLECULE / NUCLEIC ACID / マイクロチュブル結合ドメイン / tau protein / 医薬分子設計 / C-H…Π結合 / 食品 / 翻訳開始 / 翻訳制御 / 抗ガン剤 / 結晶構造解析 / SPR / ITC / 相互作用解析 / 抗がん剤 / SPR法 / ITC法 / SPR分析 / C-H…π結合 / カテプシンL / プロカテプシンL / 遺伝子組み換え / 発現 / X線解析 / 分子設計 / cathepsin L / procathepsin L / recombinant / expression / inhibitor / molecular design / HETEROMDLECULE / タングル形成機構 / 立体構造解析 / X-線結晶解析 / 分子計算 / スペクトル解析 / タングル形式 / formation mechanism of tangle / microtubule-binding domain / 3D-structure / Spectroscopic analysis / molecular modeling / 微少管結合ドメイン / フィラメント形成 / 自己会合 / 認知症治療薬 / 自己重合 / microtubule-bindine domain / filament formation / self-aggregation / Alzheimer' disease inhibiting drug Less

タウ重合に必須なCH-π相互作用阻害剤の開発:認知症治療薬開発の基盤研究
- Principal Investigator
  
  石田寿昌
- Project Period (FY)
  2011
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Drug development chemistry
- Research Institution
  Osaka University of Pharmaceutical Sciences
Discovery of novel anti-cancer drug :The search for regulatory elements of eukaryotic initiation factor 4E.
- Principal Investigator
  
  TOMOO Koji
- Project Period (FY)
  2010 – 2012
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Chemistry related to living body
- Research Institution
  Osaka University of Pharmaceutical Sciences
Development of the inhibitor for tangle formation of tau protein : Basic research for prevention of Altzheimer disease
- Principal Investigator
  
  ISHIDA Toshimasa
- Project Period (FY)
  2008 – 2010
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Drug development chemistry
- Research Institution
  Osaka University of Pharmaceutical Sciences
Elucidation of Self-aggregation Mechanism of Tau Protein : Basic Research for Drug Development of Inhibiting Alzheimer's disease
- Principal Investigator
  
  ISHIDA Toshimasa
- Project Period (FY)
  2005 – 2007
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Physical pharmacy
- Research Institution
  Osaka University of Pharmaceutical Sciences
Elucidation of Structural Effect of C-terminal Amidation of Bioactive PeptidePrincipal Investigator
- Principal Investigator
  
  IN Yasuko
- Project Period (FY)
  2002 – 2003
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Physical pharmacy
- Research Institution
  Osaka University of Pharmaceutical Sciences
Elucidatiop of Tangle Formation Mechanism Based on 3D-structural Analysis of Tau Protein
- Principal Investigator
  
  ISHIDA Toshimasa
- Project Period (FY)
  2001 – 2003
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Biophysics
- Research Institution
  Osaka University of Pharmaceutical Sciences
アシジアサイクラマイド誘導体のコンフォメーションの安定性と生理活性との相関Principal Investigator
- Principal Investigator
  
  尹康子
- Project Period (FY)
  1998
- Research Category
  
  Grant-in-Aid for Encouragement of Young Scientists (A)
- Research Field
  
  Physical pharmacy
- Research Institution
  Osaka University of Pharmaceutical Sciences
非対称環状ペプチドの立体構造の安定性と生理活性との相関Principal Investigator
- Principal Investigator
  
  尹康子
- Project Period (FY)
  1996
- Research Category
  
  Grant-in-Aid for Encouragement of Young Scientists (A)
- Research Field
  
  Physical pharmacy
- Research Institution
  Osaka University of Pharmaceutical Sciences
Interaction between heteromolecules-Structural study and application of PNA-
- Principal Investigator
  
  DOI Mitsunobu
- Project Period (FY)
  1995 – 1997
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  医薬分子機能学
- Research Institution
  Osaka University of Pharmaceutical Sciences (OUPS)
Molecular design of cathepsin L-specific inhibitor based on the teritiary structure.
- Principal Investigator
  
  ISHIDA Toshimasa
- Project Period (FY)
  1994 – 1996
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  医薬分子機能学
- Research Institution
  Osaka University of Pharmaceutical Sciences
海洋産環状ペプチドの立体構造解析と生理活性相関Principal Investigator
- Principal Investigator
  
  いん康子
- Project Period (FY)
  1993
- Research Category
  
  Grant-in-Aid for Encouragement of Young Scientists (A)
- Research Field
  
  Physical pharmacy
- Research Institution
  Osaka University of Pharmaceutical Sciences

All 2012 2011 2010 2009 2008 2007 2006 2005

All Journal Article Presentation

[Journal Article] C-H…π interplay between Ile308 and Tyr310 residues in the third repeat of microtubule binding domain is indispensable for self-assembly of three- and four repeat tau2012
- Author(s)
  Koushirou Sogawa, Ryouhei Okuda, Ysauko In, Toshimasa Ishida, Taizo Taniguchi, Katsuhiko Minoura, Koji Tomoo
- Journal Title
  
  J.Biochem.
  
  Volume: 151(In press)
- NAID
  10031166133
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23590138
[Journal Article] A conserved motif within the flexible C-terminus of the translational regulator 4E-BP is required for tight binding to the mRNA cap-binding protein eIF4E.2012
- Author(s)
  Paku KS., Umenaga Y., Usui T., FukuyoA., Mizuno A., Ishida T. and Tomoo K
- Journal Title
  
  Biochem J.
  
  Volume: 441 Pages: 237-245
- DOI
  10.1042/bj20101481
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22550158
[Journal Article] Structural scaffold for eIF4E binding selectivity of 4E-BP isoforms : crystal structure of eIF4E binding region of 4E-BP2 and its comparison with that of 4E-BP12011
- Author(s)
  Fukuyo A., In Y., Ishida T. and Tomoo K
- Journal Title
  
  J.Pept.Sci.
  
  Volume: 17 Pages: 650-657
- DOI
  10.1002/psc.1384
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22550158
[Journal Article] Identification and function of the second eIF4E-binding region in N-terminal domain of eIF4G : comparison with eIF4E-binding protein2011
- Author(s)
  Umenaga Y. Paku KS, In Y., Ishida T.and Tomoo K
- Journal Title
  
  Biochem Biophys Res Commun
  
  Volume: 414 Pages: 462-467
- DOI
  10.1016/j.bbrc.2011.09.084
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22550158
[Journal Article] Interplay between I308 and Y310 residues in the their repeat of mucrotubule-binding domain is essential for tau filament formation2010
- Author(s)
  K.Naruto, K.Minoura, R.Okuda, T.Taniguchi, Y.In, T.Ishida, K.Tomoo
- Journal Title
  
  FEBS Lett. 584
  
  Pages: 4233-4236
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590111
[Journal Article] Importance of Tyr310 residue in the third repeat of microtubule binding domain for filament formation of tau protein2010
- Author(s)
  C.Nishiura, K.Takeuchi, K.Minoura, M.Sumida, T.Taniguchi, K.Tomoo, T.Ishida
- Journal Title
  
  J.Biochem. 147
  
  Pages: 405-414
- NAID
  10027874643
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590111
[Journal Article] Importance of Tyr310 residue in the third repeat of microtubule binding domain for filament formation of tau protein2010
- Author(s)
  C.Nishiura, K.Takeuchi, K.Minoura, M.Sumida, T.Taniguchi, K.Tomoo, T.Ishida
- Journal Title
  
  J.Biochem.
  
  Volume: 147 Pages: 405-414
- NAID
  10027874643
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590111
[Journal Article] Structural role of tyrosine residue in the their repeat of microtubule binding domain for filament formation of tau protein2010
- Author(s)
  K.Minoura, K.Takeuchi, C.Nishiura, K.Naruto, M.Sumida, T.Taniguchi, K.Tomoo, T.Ishida
- Journal Title
  
  Peptide Science
  
  Volume: 2009 Pages: 227-230
- Data Source
  KAKENHI-PROJECT-20590111
[Journal Article] Structural role of tyrosine residue in the their repeat of microtubule binding domaion for filament formation of tau protein2010
- Author(s)
  K.Minoura, K.Takeuchi, C.Nishiura, K.Naruto, M.Sumida, T.Taniguchi, K.Tomoo, T.Ishida
- Journal Title
  
  Peptide Science 2009
  
  Pages: 227-230
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590111
[Journal Article] Interplay between I308 and Y310 residues in the their repeat of mucrotubule-binding domain is essential for tau filament formation2010
- Author(s)
  K.Naruto, K.Minoura, R.Okuda, T.Taniguchi, Y.In, T.Ishida, K.Tomoo
- Journal Title
  
  FEBS Lett.
  
  Volume: 6584 Pages: 4233-4236
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590111
[Journal Article] Inhibitory behavior of cyanidine and methylene blue for filament formation of tau microtubule-binding domain2009
- Author(s)
  E.Sugino, M.Hattori, K.Minoura, Y.In, M.Sumida, T.Taniguchi, K.Tomoo, T.Ishida
- Journal Title
  
  Peptide Science 2008
  
  Pages: 331-334
- NAID
  10027166463
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590111
[Journal Article] Importance of tyrosine residue for filament formation of tau microtubule-binding domain2009
- Author(s)
  C.Nishiura, K.Takeuchi, K.Naruto, K.Minoura, M.Sumida, T.Taniguchi, K.Tomoo, T.Ishida
- Journal Title
  
  Peptide Science 2008
  
  Pages: 235-238
- NAID
  10027166266
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590111
[Journal Article] Three-/four repeat-dependent aggregation profile of tau microtubule-binding domain clarified by dynamic light scattering analysis2009
- Author(s)
  E.Sugino, C.Nishiura, K.Minoura, Y.In, M.Sumida, T.Taniguchi, K.Tomoo, T.Ishida
- Journal Title
  
  Biochem.Biophys.Res.Commun. 385
  
  Pages: 236-240
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590111
[Journal Article] Linkage-dependent contribution of repeat peptides to self-aggregation of three- or four-repeat microtubule-binding domains in tau protein2008
- Author(s)
  K.Okuyama, C.Nishiura, F.Mizushima, K.Minoura, M.Sumida, T.Taniguchi, K.Tomoo, T.Ishida
- Journal Title
  
  FEBS Journal 275
  
  Pages: 1529-1539
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590111
[Journal Article] Role of each peptide in aggregation of tau microtubule-binding domain2008
- Author(s)
  K. Minoura, K. Okuyama, C. Nishiura, F. Mizushima, M. Sumida, T. Taniguchi, K. Tomoo, T. Ishida
- Journal Title
  
  Peptide Science 2007
  
  Pages: 59-62
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590111
[Journal Article] Different inhibitory response of cyanidin and methylene blue for filament formation of tau microtubule-binding domain2008
- Author(s)
  M. Hattori, E. Sugino, K. Minoura, Y. In, M. Sumida, T. Taniguchi, K. Tomoo, T. Ishida
- Journal Title
  
  Biochem. Biophys. Res. Commun. 374
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590111
[Journal Article] Linkage-dependent contribution of repeat peptides to self-aggregation of three-or four-repeat microtubule-binding domains in tau protein2008
- Author(s)
  K. Okuyama, C. Nishiura, F. Mizushima, K. Minoura, M. Sumida, T. Taniguchi, K. Tomoo, T. Ishida
- Journal Title
  
  FEBS Journal 275
  
  Pages: 1529-1539
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590111
[Journal Article] Different inhibitory response of cyanidin and methylene blue for filament formation of tau microtubule-binding domain2008
- Author(s)
  M.Hattori, E.Sugino, K.Minoura, Y.In, M.Sumida, T.Taniguchi, K.Tomoo, T.Ishida
- Journal Title
  
  Biochem.Biophys.Res.Commun. 374
  
  Pages: 158-163
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590111
[Journal Article] Role of each peptide in aggregation of tau microtubule-binding domain2008
- Author(s)
  K.Minoura, K.Okuyama, C.Nishiura, F.Mizushima, M.Sumida, T.Taniguchi, K.Tomoo, T.Ishida
- Journal Title
  
  Peptide Science 2007
  
  Pages: 59-62
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590111
[Journal Article] Marked difference between self-aggregations of first and fourth repeat peptides on tau microtubule-binding domain in acidic solution2007
- Author(s)
  F.Mizushima, K.Minoura, K.Tomoo, M.Sumida, T.Taniguchi, T.Ishida
- Journal Title
  
  J.Biochem 142
  
  Pages: 49-54
- NAID
  10020097851
- Description
  「研究成果報告書概要(和文)」より
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17590045
[Journal Article] Effect of DNA on filament formation of tau microtubule-binding domain: Structural dependence of DNA2007
- Author(s)
  R. Hikosou, Y. Kurabayashi, M. Doumoto, K. Hoshitoku, F. Mizushima, K. Minoura, K. Tomoo, T. Ishida
- Journal Title
  
  Chem. Pharm. Bull. 55
  
  Pages: 1030-1033
- NAID
  110006317167
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17590045
[Journal Article] Marked difference between self-aggregations of first and fourth repeat peptides on microtubule-binding domain in acidic solution2007
- Author(s)
  F. Mizushima, K. Minoura, K. Tomoo, M. Sumida, T. Taniguchi, T. Ishida
- Journal Title
  
  J. Biochem. 142
  
  Pages: 49-54
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17590045
[Journal Article] Effect of DNA on filament formation of tau microtubulu-binding domain:Structural dependence of DNA2007
- Author(s)
  R.Hikosou, Y.Kurabayashi, M.Doumoto, K.Hoshitoku, F.Mizushima, M.Minoura, K.Tomoo, T.Ishida
- Journal Title
  
  Chem.Pharm.Bull 55
  
  Pages: 1030-1033
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17590045
[Journal Article] Effect of DNA on filament formation of tau microtubule-binding domain:Structural dependence of DNA2007
- Author(s)
  R.Hikosou, Y.Kurabayashi, M.Doumoto, K.Hoshitoku, F.Mizushima, K.Minoura, K.Tomoo, T.Ishida
- Journal Title
  
  Chem.Pharm.Bull 55
  
  Pages: 1030-1033
- Description
  「研究成果報告書概要(和文)」より
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17590045
[Journal Article] Fluorescence-coupled CD conformational monitoring of filament formation of tau microtubule-binding repeat domain2006
- Author(s)
  F.Mizushima, K.Minoura, K.Tomoo, M.Sumida, T.Taniguchi, T.Ishida
- Journal Title
  
  Biochem. Biophys. Res. Commun. 343
  
  Pages: 712-718
- Data Source
  KAKENHI-PROJECT-17590045
[Journal Article] N-Terminal secondary structures of second and third repeat fragment responsible for self-assembly of tau microtubule-binding domain2006
- Author(s)
  Katsuhiko Minoura, Man Tokimasa, Shuko Hiraoka, Fumie Mizushima, Koji Tomoo, Miho Sumida, Taizo Taniguchi, Toshimasa Ishida
- Journal Title
  
  Peptide Sciences 2005
  
  Pages: 367-370
- NAID
  10017675968
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17590045
[Journal Article] N-Terminal secondary structures of second and third repeat fragment responsible for self-assembly of tau microtubule-binding domain2006
- Author(s)
  K.Minoura, M.Tokimasa, S.Hiraoka, F.Mizushima, K.Tomoo, M.Sumida, T.Taniguchi, T.Ishida
- Journal Title
  
  Peptide Science 2005
  
  Pages: 367-370
- NAID
  10017675968
- Data Source
  KAKENHI-PROJECT-17590045
[Journal Article] Fluorescence-coupled CD conformational monitoring of filament formation of tau microtubule-binding repeat domain2006
- Author(s)
  F. Mizushima, K.Minoura, K. Tomoo, M. Sumida, T. Taniguchi, T. Ishida
- Journal Title
  
  Biochem. Biophys. Res. Commun. 343
  
  Pages: 712-718
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17590045
[Journal Article] PH-dependent filament formation of repeat peptide of microtubule-binding domain of tau protein2006
- Author(s)
  F.Mizushima, K.Minoura, K.Tomoo, S.Hiraoka, M.Sumida, T.Taniguchi, T.Ishida
- Journal Title
  
  Peptide Science 2005
  
  Pages: 305-308
- NAID
  10017675852
- Description
  「研究成果報告書概要(和文)」より
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17590045
[Journal Article] Fluorescence-coupled CD conformational monitoring of filament formation of tau microtubule-binding repeat domain2006
- Author(s)
  F.Mizushima, K.Minoura, K.Tomoo, M.Sumida, T.Taniguchi, T.Ishida
- Journal Title
  
  Biochem.Biophys.Res.Commun 343
  
  Pages: 712-718
- Description
  「研究成果報告書概要(和文)」より
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17590045
[Journal Article] PH-dependent filament formation of repeat peptide of microtubule-binding domain of tau protein2006
- Author(s)
  F. Mizushima, K. Minoura, K. Tomoo, S. Hiraoka, M. Sumida, T. Taniguchi, T. Ishida
- Journal Title
  
  Peptide Science 2005
  
  Pages: 305-308
- NAID
  10017675852
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17590045
[Journal Article] N-Terminal secondary structures of second and third repeat fragment responsible for self-assembly of tau microtubule-binding domain2006
- Author(s)
  K.Minoura, M Tokimasa, S Hiraoka, F Mizushima, K Tomoo, M Sumida, T Taniguchi, T Ishida
- Journal Title
  
  Peptide Sciences 2005
  
  Pages: 367-370
- NAID
  10017675968
- Description
  「研究成果報告書概要(和文)」より
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17590045
[Journal Article] Structural evaluation of conformational transition state responsible for self-assembly of tau microtubule-binding domain2005
- Author(s)
  K.Minoura, F.Mizushima, M.Tokimasa, S.Hiraoka, K.Tomoo, M.Sumida, T.Taniguchi, T.Ishida
- Journal Title
  
  Biochem.Biophys.Res.Commun 327
  
  Pages: 1100-1104
- Description
  「研究成果報告書概要(和文)」より
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17590045
[Journal Article] Possible role of each repeat strcuutre of the microtubule-binding domain of the tau protein in in vitro aggregation2005
- Author(s)
  K.Tomoo, T.M.Yao, K.Minoura, S.Hiraoka, M.Sumida, T.Taniguchi, T.Ishida
- Journal Title
  
  J.Biochem. 138
  
  Pages: 413-423
- Data Source
  KAKENHI-PROJECT-17590045
[Journal Article] Structural evaluation of conformational transition state responsible for self-assembly of tau microtubule-binding domair2005
- Author(s)
  K. Minoura, F. Mizushima, M. Tokimasa, S. Hiraoka, K. Tomoo, M. Sumida, T. Taniguchi, T. Ishida
- Journal Title
  
  Biochem. Biophys. Res. Commun. 327
  
  Pages: 1100-1104
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17590045
[Journal Article] Structural evaluation of conformational transition state responsible for self-assembly of tau microtubule-binding domain2005
- Author(s)
  K.Minoura, F.Mizushima, M.Tokimasa, S.Hiraoka, K.Tomoo, M.Sumida, T.Taniguchi, T.Ishida
- Journal Title
  
  Biochem.Biophys.Res.Commun. 327
  
  Pages: 1100-1104
- Data Source
  KAKENHI-PROJECT-17590045
[Journal Article] Importance of local structures of second and thirs repeat fragments of microtubule-binding domain for tau filament formation2005
- Author(s)
  M. Tokimasa, K. Minoura, S. Hiraoka, K. Tomoo, M. Sumida, T. Taniguchi, T. Ishida
- Journal Title
  
  FEBS Lett. 579
  
  Pages: 3481-3486
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17590045
[Journal Article] Importance of local structures of second and thirs repeat fragments of microtubule-binding domain for tau filament formation2005
- Author(s)
  M.Tokimasa, K.Minoura, S.Hiraoka, K.Tomoo, M.Sumida, T.Taniguchi, T.Ishida
- Journal Title
  
  FEBS Lett. 579
  
  Pages: 3481-3486
- Description
  「研究成果報告書概要(和文)」より
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17590045
[Journal Article] Possible role of each repeat strucutre of the microtubule-binding domain of the tau protein in in vitro aggregation2005
- Author(s)
  K. Tomoo, T.-M. Yao, K. Minoura, S. Hiraoka, M. Sumida, T. Taniguchi, T. Ishida
- Journal Title
  
  J. Biochem. 138
  
  Pages: 413-423
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17590045
[Journal Article] Effects of different anti-tau antibodies on tau fibrillogenesis: RTA-1 and RTA-2 counteract tau aggregation2005
- Author(s)
  T. Taniguchi, M. Sumida, S. Hiraoka, K.Tomoo, T. Kakehi, K.Minoura, S. Sugiyama, K.Inaka, T. Ishida, N. Saito, C. Tanaka
- Journal Title
  
  FEBS Lett. 579
  
  Pages: 1399-1404
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17590045
[Journal Article] Solvent-dependent conformational change of third repeat fragment of microtubule-binding domain responsible for fliament formation of tau protein.2005
- Author(s)
  K. Minoura, F. Mizushirna, M. Tokimasa, S. Hiraoka, K. Tomoo, M. Sumida, T. Taniguchi, T. Ishida
- Journal Title
  
  Peptide Science 2004
  
  Pages: 545-548
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17590045
[Journal Article] Effects of different anti-tau antibodies on tau fibrillogenesis:RTA-1 and RTA-2 counteract tau aggregation2005
- Author(s)
  T.Taniguchi, M.Sumida, S.Hiraoka, K.Tomoo, T.Kakehi, K.Minoura, S.Sugiyama, K.Inaka, T.Ishida, N.Saito, C.Tanaka
- Journal Title
  
  FEBS Lett. 579
  
  Pages: 1399-1404
- Description
  「研究成果報告書概要(和文)」より
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17590045
[Journal Article] Effects of different anti-tau antibodies on tau fibrillogenesis : RTA-1 and RTA-2 counteract tau aggregation2005
- Author(s)
  T.Taniguchi, M.Sumida, S.Hiraoka, K.Tomoo, T.Kakehi, K.Minoura, S.Sugiyama, K.Inaka, T.Ishida, N.Saito, C.Tanaka
- Journal Title
  
  FEBS Lett 579
  
  Pages: 1399-1404
- Data Source
  KAKENHI-PROJECT-17590045
[Journal Article] Possible role of each repeat strucutre of the microtubule-binding domain of the tau protein in in vitro aggregation2005
- Author(s)
  K.Tomoo, T.-M.Yao, K.Minoura, S.Hiraoka, M.Sumida, T.Taniguchi, T.Ishida
- Journal Title
  
  J.Biochem 138
  
  Pages: 413-423
- Description
  「研究成果報告書概要(和文)」より
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17590045
[Journal Article] Importance of local structures of second and thirs repeat fragments of microtubule-binding domain for tau filament formation2005
- Author(s)
  M.Tokimasa, K.Minoura, S.Hiraoka, K.Tomoo, Sumida, T.Taniguchi, T.Ishida
- Journal Title
  
  FEBS Lett. 579
  
  Pages: 3481-3486
- Data Source
  KAKENHI-PROJECT-17590045
[Journal Article] Solvent-dependent conformational change of third repeat fragment of microtubule-binding domain responsible for filament formation of tauprotein2005
- Author(s)
  K.Minoura, F.Mizushima, M.Tokimasa, S.Hiraoka, K.Tomoo, M.Sumida, T.Taniguchi, T.Ishida
- Journal Title
  
  Peptide Science 2004
  
  Pages: 545-548
- NAID
  10014460563
- Description
  「研究成果報告書概要(和文)」より
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17590045
[Journal Article] Solvent-dependent conformarional change of third repeat fragment of microtubule-binding domain responsible for filament formation of tau protein2005
- Author(s)
  K.Minoura, F.Mizushima, M.Tokimasa, S.Hiraoka, K.Tomoo, M.Sumida, T.Taniguchi, T.Ishida
- Journal Title
  
  Protein Science 2004
  
  Pages: 545-548
- Data Source
  KAKENHI-PROJECT-17590045
[Presentation] Tauタンパク質の自己凝集抑制能を有する特異的認識抗体の作成とその複合体結晶化による構造機能解析2012
- Author(s)
  須佐匡樹, 土屋孝弘, 箕浦克彦, 尹康子, 友尾幸司, 谷口泰造, 辻坊裕, 石田寿昌
- Organizer
  日本薬学会132年会
- Place of Presentation
  北海道大学(札幌)
- Data Source
  KAKENHI-PROJECT-23590138
[Presentation] Tauタンパク質の自己重合におけるIle308とTyr310が形成するCH-π相互作用の重要性2012
- Author(s)
  曾川甲子郎, 奥田良平, 箕浦克彦, 尹康子, 友尾幸司, 石田寿昌
- Organizer
  日本薬学会132年会
- Place of Presentation
  北海道大学(札幌)
- Data Source
  KAKENHI-PROJECT-23590138
[Presentation] Tauタンパク質の自己凝集抑制能を有する特異的認識抗体の作成とその構造機能解析2011
- Author(s)
  須佐匡樹, 土屋孝弘, 箕浦克彦, 尹康子, 友尾幸司, 辻坊裕, 石田寿昌, 他
- Organizer
  第61回日本薬学会近畿支部総会・大会
- Place of Presentation
  神戸学院
- Data Source
  KAKENHI-PROJECT-23590138
[Presentation] ヒト由来タンパク質生合成開始因子 eIF4E と eIF4G 及び内因性制御因子 4EBP サブタイプの相互作用研究2011
- Author(s)
  梅永優、朴琴順、尹康子、友尾幸司、石田寿昌
- Organizer
  日本薬学会第131 年会
- Place of Presentation
  静岡
- Data Source
  KAKENHI-PROJECT-22550158
[Presentation] Tauタンパク質の自己重合におけるIle308とTyr310が形成するCH-π相互作用の重要性2011
- Author(s)
  曾川甲子郎, 箕浦克彦, 尹康子, 友尾幸司, 石田寿昌
- Organizer
  第61回日本薬学会近畿支部総会・大会
- Place of Presentation
  神戸学院
- Data Source
  KAKENHI-PROJECT-23590138
[Presentation] CH-π interaction between I308 and Y310 residues is required for self assembly of full length tau2011
- Author(s)
  曾川甲子郎, 奥田良平, 箕浦克彦, 尹康子, 友尾幸司, 石田寿昌, 他
- Organizer
  第48回ペプチド討論会
- Place of Presentation
  北海道大学(札幌)
- Data Source
  KAKENHI-PROJECT-23590138
[Presentation] Full length tau の自己重合におけるCH-π相互作用の重要性について2010
- Author(s)
  奥田良平、鳴戸佳子、箕浦克彦、尹康子、友尾幸司、谷口泰造、石田寿昌
- Organizer
  第130会日本薬学会近畿支部大会
- Place of Presentation
  大阪
- Year and Date
  2010-10-30
- Data Source
  KAKENHI-PROJECT-20590111
[Presentation] Tauタンパク質の自己凝集抑制能を有する特異的認識抗体の作成とその構造機能解析2010
- Author(s)
  木挽友博、土屋孝弘、箕浦克彦、尹康子、友尾幸司、谷口泰造、辻坊裕、石田寿昌
- Organizer
  日本薬学会第130年会
- Place of Presentation
  岡山
- Data Source
  KAKENHI-PROJECT-20590111
[Presentation] ヒト由来タンパク質生合成開始因子 eIF4E と内因性制御因子 4EBP サブタイプ及び eIF4G の相互作用研究2010
- Author(s)
  梅永優、朴琴順、尹康子、友尾幸司、石田寿昌
- Organizer
  第60回日本薬学会近畿支部総会・大会
- Place of Presentation
  大阪
- Data Source
  KAKENHI-PROJECT-22550158
[Presentation] Full length tauの自己重合におけるCH-π相互作用の重要性について2010
- Author(s)
  奥田良平、鳴戸佳子、箕浦克彦、尹康子、友尾幸司、谷口泰造、石田寿昌
- Organizer
  第130会日本薬学会近畿支部大会
- Place of Presentation
  大阪
- Data Source
  KAKENHI-PROJECT-20590111
[Presentation] Tauタンパク質微小管結合ドメイン(MBD)におけるCH-π相互作用がもたらすフィラメント形成能への影響について2010
- Author(s)
  曽川甲子朗、箕浦克彦、尹康子、友尾幸司、石田寿昌
- Organizer
  第130会日本薬学会近畿支部大会
- Place of Presentation
  大阪
- Data Source
  KAKENHI-PROJECT-20590111
[Presentation] Tauタンパク質微小管結合ドメイン(MBD)の自己重合におけるTyrosine残基と周囲のアミノ酸残基の重要性について2010
- Author(s)
  鳴戸佳子、箕浦克彦、尹康子、友尾幸司、石田寿昌
- Organizer
  日本薬学会第130年会
- Place of Presentation
  岡山
- Data Source
  KAKENHI-PROJECT-20590111
[Presentation] tauタンパク質微小管結合ドメインのフィラメント形成に対する Cyanidin(Cy)と Methylene Blue(MB)の阻害作用の差異について2009
- Author(s)
  杉野恵津子, 服部正幹, 箕浦克彦, 尹康子, 友尾幸司, 石田寿昌
- Organizer
  日本薬学会第129年会
- Place of Presentation
  京都
- Data Source
  KAKENHI-PROJECT-20590111
[Presentation] Tau蛋白質の自己凝集抑制能を有する特異的認識抗体の作成とその構造解析2009
- Author(s)
  木挽友博、土屋孝弘、箕浦克彦、尹康子、友尾幸司、辻坊裕、石田寿昌
- Organizer
  第59回日本薬学会近畿支部大会
- Place of Presentation
  大阪
- Data Source
  KAKENHI-PROJECT-20590111
[Presentation] Tauタンパク微小管結合ドメイン(MBD)の自己重合におけるTyrosine残基の重要性について2009
- Author(s)
  鳴戸佳子、箕浦克彦、尹康子、友尾幸司、辻坊裕、石田寿昌
- Organizer
  第59回日本薬学会近畿支部大会
- Place of Presentation
  大阪
- Data Source
  KAKENHI-PROJECT-20590111
[Presentation] Tauタンパク微小管結合ドメイン(MBD)の自己重合における Tyrosine 残基の重要性について2009
- Author(s)
  鳴戸佳子, 箕浦克彦, 尹康子, 友尾幸司, 辻坊裕, 石田寿昌
- Organizer
  第59回日本薬学会近畿支部大会
- Place of Presentation
  大阪
- Data Source
  KAKENHI-PROJECT-20590111
[Presentation] tauタンパク質微小管結合ドメインのフィラメント形成に対するCyanidin(Cy)とMethylene Blue(MB)の阻害作用の差異について2009
- Author(s)
  杉野恵津子、服部正幹、箕浦克彦、尹康子、友尾幸司、石田寿昌
- Organizer
  日本薬学会第129年会
- Place of Presentation
  京都
- Data Source
  KAKENHI-PROJECT-20590111
[Presentation] Tauタンパク質の微小管結合ドメインに存在するTyrosinwが構造に与える影響2008
- Author(s)
  竹内健悟、西浦千里、箕浦克彦、友尾幸司、尹康子、石田寿昌
- Organizer
  第58回日本薬学会近畿支部大会
- Place of Presentation
  神戸
- Data Source
  KAKENHI-PROJECT-20590111
[Presentation] Cyanidine(Cy)とMethylene Blue(MB)におけるTauタンパク質微小管結合部位のフィラメント形成抑制作用の差異2008
- Author(s)
  杉野恵津子、服部正幹、箕浦克彦、尹康子、友尾幸司、石田寿昌
- Organizer
  第58回日本薬学会近畿支部大会
- Place of Presentation
  神戸
- Data Source
  KAKENHI-PROJECT-20590111
[Presentation] Role of Each Repeat Peptide in Aggregation of Tau Microtubule-binding Domain2007
- Author(s)
  K. Minoura, et. al.
- Organizer
  44th Peptide Symposium
- Place of Presentation
  Toyama
- Year and Date
  2007-11-09
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17590045
[Presentation] Importance of N-terminal secondary structure of repeat fragment in self-aggregation of tau MBD2005
- Author(s)
  K. Minoura, et. al.
- Organizer
  42th Peptide Symposium
- Place of Presentation
  Osaka
- Year and Date
  2005-10-28
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17590045

1. TOMOO Koji (70257898)

# of Collaborated Projects: 7 results

# of Collaborated Products: 66 results
2. ISHIDA Toshimasa (00111021)

# of Collaborated Projects: 6 results

# of Collaborated Products: 61 results
3. MINOURA Katsuhiko (10278591)

# of Collaborated Projects: 5 results

# of Collaborated Products: 63 results
4. DOI Mitsunobu (10183500)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
5. ASANO Akiko (40291801)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. TANIGUCHI Taizo (70346253)

# of Collaborated Projects: 1 results

# of Collaborated Products: 25 results
7. 樽井麻里子 (60257897)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results

IN Yasuko 尹 康子

いん 康子 イン ヤスコ

Research Projects

Research Products

Co-Researchers

タウ重合に必須なCH-π相互作用阻害剤の開発:認知症治療薬開発の基盤研究

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Discovery of novel anti-cancer drug :The search for regulatory elements of eukaryotic initiation factor 4E.

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Development of the inhibitor for tangle formation of tau protein : Basic research for prevention of Altzheimer disease

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Elucidation of Self-aggregation Mechanism of Tau Protein : Basic Research for Drug Development of Inhibiting Alzheimer's disease

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Elucidation of Structural Effect of C-terminal Amidation of Bioactive PeptidePrincipal Investigator

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Elucidatiop of Tangle Formation Mechanism Based on 3D-structural Analysis of Tau Protein

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アシジアサイクラマイド誘導体のコンフォメーションの安定性と生理活性との相関Principal Investigator

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非対称環状ペプチドの立体構造の安定性と生理活性との相関Principal Investigator

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Interaction between heteromolecules-Structural study and application of PNA-

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Molecular design of cathepsin L-specific inhibitor based on the teritiary structure.

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海洋産環状ペプチドの立体構造解析と生理活性相関Principal Investigator

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[Journal Article] C-H…π interplay between Ile308 and Tyr310 residues in the third repeat of microtubule binding domain is indispensable for self-assembly of three- and four repeat tau2012

Author(s)

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NAID

Data Source

[Journal Article] A conserved motif within the flexible C-terminus of the translational regulator 4E-BP is required for tight binding to the mRNA cap-binding protein eIF4E.2012

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DOI

IN Yasuko 尹康子

いん康子インヤスコ