Mizobata Tomohiro 溝端知宏

… Alternative Names

MIZOBATA Tomohiro 溝端知宏

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Researcher Number	50263489
Other IDs
External Links
Affiliation (Current)	2022: 鳥取大学, 工学研究科, 教授
Affiliation (based on the past Project Information) *help	2019 – 2021: 鳥取大学, 工学研究科, 教授 2015: 鳥取大学, 大学院工学研究科, 准教授 2012 – 2015: 鳥取大学, 工学(系)研究科(研究院), 准教授 2011 – 2012: 鳥取大学, 大学院・工学研究科, 准教授 2010 – 2011: 鳥取大学, 工学研究科, 准教授 … More 2006: Tottori University, Faculty of Engineering, Associate Professor 2005 – 2006: Tottori University, Faculty of Engineering, Associate Professor, 工学部, 助教授 2004: 国立大学法人鳥取大学, 工学部, 助教授 2001 – 2003: Tottori University, Faculty of Engineering, Associate Professor, 工学部, 助教授 2001: 鳥取大学, 工学部, 教授 1994 – 2000: 鳥取大学, 工学部, 助手 Less
Review Section/Research Field	Principal Investigator Structural biochemistry / Biophysics / Structural biochemistry / Basic Section 43020:Structural biochemistry-related Except Principal Investigator Structural biochemistry / Structural biochemistry / Biological Sciences / Biophysics
Keywords	Principal Investigator シャペロニン / 分子シャペロン / フォールディング / 蛋白質フォールディング / 熱ショック蛋白質 / GroEL / 蛍光 / ストップト・フロー解析 / 円順列変異 / GroE … More / 古細菌 / 超好熱性 / 部位特異的変異導入法 / ストップト・フロー分光法 / ストップトフロー / 部位特異的変異導入 / 変性とフォールディング / ストップト・フロー / ペリプラズム / アミロイド線維 / 機能的変性構造 / 大腸菌 / グラム陰性細菌 / 機能的変性蛋白質 / 天然変性構造 / 天然変性領域 … More Except Principal Investigator シャペロニン / 分子シャペロン / αシヌクレイン / アミロイド線維 / 機能発現機構 / コンフォメーション変化 / GroEL / 構造安定性 / GroES / GroE / 立体構造形成 / アミロイド様線維形成 / 脳神経変性病 / タンパク質 / 細胞毒性 / シャペロニンGroES / オリゴマー蛋白質 / 神経変性病 / アミロイド線維形成 / Molecular chaperone / Chaperonin / Amyloid fibril / Oligomeric protein / ストレス蛋白質 / キャピラリー電気泳動 / 複合体形成 / 基質認識機構 / GroEL変異体 / 加水分解エネルギー / (1)分子シャペロン / 基質認識 / 速度論 / ストップフロー / ヌクレオチド特異性 / ADP依存的シャペロニンサイクル / シャベロニン / 機能発現 / ATP加水分解 / 一分子 / 安定性 / パーキンソン病 / 蛋白質 / 天然変性 / 生体分子 / 天延変性 / トリオースリン酸イソメラーゼ / アミロイド様線維形成機構 / アグリゲーション / インクルージョンボディ / Conformational changes / Amyloid-like fibril formation / Triose phosphate isomerase / Chaperonin GroES / α Synuclein / 構造形成反応 / 耐熱性酵素 / 耐熱性シャペロニン / オリゴマー酵素 / シャペロニンGroEL / Conformational change / Folding / Thermostable enzyme / Ncurodegenerative disease / 分子のコンパクトさ / コンフォメーション病 / 構造変化 / 蛋白質の構造安定性 / α-synuclein / Molecular compactness / Functional mechanism / Neurodegenerative disease / タンパク質凝集抑制 / 凝集抑制 / アントシアニン / SOD1 / Aβペプチド / 蛋白質凝集 / アミノ酸電荷 / ポリフェノール Less

E. coli HdeA: Analysis of the reversible formation of fibrils by an environmentally responsive molecular chaperonePrincipal Investigator
- Principal Investigator
  
  Mizobata Tomohiro
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 43020:Structural biochemistry-related
- Research Institution
  Tottori University
Re-evaluation of the molecular mechanism of chaperonin action: characterization of circularly-permuted GroELPrincipal Investigator
- Principal Investigator
  
  Mizobata Tomohiro
- Project Period (FY)
  2013 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Structural biochemistry
- Research Institution
  Tottori University
Evaluation of cytotoxicity and control of protein aggregation in the amyloid fibril formation
- Principal Investigator
  
  Kawata Yasushi
- Project Period (FY)
  2013 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Structural biochemistry
- Research Institution
  Tottori University
Functional and kinetic analysis of the inter-domain communication network of the chaperonin GroELPrincipal Investigator
- Principal Investigator
  
  MIZOBATA Tomohiro
- Project Period (FY)
  2010 – 2012
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Structural biochemistry
- Research Institution
  Tottori University
Structural and functional characteristics of natively unfolded protein
- Principal Investigator
  
  KAWATA Yasushi
- Project Period (FY)
  2009 – 2011
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Structural biochemistry
- Research Institution
  Tottori University
Molecular study on large conformational changes of protein that relates biofunction and diseases
- Principal Investigator
  
  KAWATA Yasushi
- Project Period (FY)
  2003 – 2005
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Structural biochemistry
- Research Institution
  Tottori University
Protein conformational changes and molecular chaperone
- Principal Investigator
  
  KAWATA Yasushi
- Project Period (FY)
  2002 – 2006
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Tottori University
脳細胞変性の治療を目指したαシヌクレインアミロイド線維形成機構の分子論的研究
- Principal Investigator
  
  河田康志
- Project Period (FY)
  2001
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas (C)
- Review Section
  
  Biological Sciences
- Research Institution
  Tottori University
シャペロニンGroE存在下でのフォールディング反応条件を規定する分子機構の解明Principal Investigator
- Principal Investigator
  
  溝端知宏
- Project Period (FY)
  2000 – 2001
- Research Category
  
  Grant-in-Aid for Encouragement of Young Scientists (A)
- Research Field
  
  Biophysics
- Research Institution
  Tottori University
Molecular basic research on protein aggregation and conformational diseases
- Principal Investigator
  
  KAWATA Yasushi
- Project Period (FY)
  2000 – 2001
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Structural biochemistry
- Research Institution
  Tottori University
分子シャペロンの基質認識とヌクレオチド加水分解活性
- Principal Investigator
  
  河田康志
- Project Period (FY)
  1999
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas (A)
- Research Institution
  Tottori University
変異型GroELを用いたシャペロニンの標的蛋白質結合メカニズムの解析Principal Investigator
- Principal Investigator
  
  溝端知宏
- Project Period (FY)
  1998 – 1999
- Research Category
  
  Grant-in-Aid for Encouragement of Young Scientists (A)
- Research Field
  
  Structural biochemistry
- Research Institution
  Tottori University
シャペロニンGroELの機能発現機構の新側面の検証
- Principal Investigator
  
  河田康志
- Project Period (FY)
  1997 – 1998
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  Biophysics
- Research Institution
  Tottori University
分子シャペロンを用いた蛋白質立体構造構築原理の解明
- Principal Investigator
  
  河田康志
- Project Period (FY)
  1996
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Tottori University
三種混合ストップトフローを用いる分子シャペロンの機能発現機構の速度論的解析
- Principal Investigator
  
  河田康志
- Project Period (FY)
  1996
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Structural biochemistry
- Research Institution
  Tottori University
耐熱性古細菌由来のシャペロニン蛋白質の性質決定Principal Investigator
- Principal Investigator
  
  溝端知宏
- Project Period (FY)
  1996
- Research Category
  
  Grant-in-Aid for Encouragement of Young Scientists (A)
- Research Field
  
  Biophysics
- Research Institution
  Tottori University
分子シャペロンを用いた蛋白質立体構造構築原理の解明
- Principal Investigator
  
  河田康志
- Project Period (FY)
  1995
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Tottori University
キャピラリー電気泳動による分子シャペロンGroEの構造機能解析
- Principal Investigator
  
  河田康志
- Project Period (FY)
  1995
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  Structural biochemistry
- Research Institution
  Tottori University
シャペロニン蛋白質の作用機構に関する速度論的解析Principal Investigator
- Principal Investigator
  
  溝端知宏
- Project Period (FY)
  1995
- Research Category
  
  Grant-in-Aid for Encouragement of Young Scientists (A)
- Research Field
  
  Structural biochemistry
- Research Institution
  Tottori University
原核生物のストレス蛋白質の構造と機能
- Principal Investigator
  
  KAWATA Yasushi
- Project Period (FY)
  1994
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Tottori University

[Book] Aspartases : molecular structure, biochemical function and biotechnological applications2007
- Author(s)
  Tomohiro Mizobata, Yasushi Kawata
- Total Pages
  563
- Publisher
  Springer Science (Dordrecht)
- Data Source
  KAKENHI-PROJECT-14037241
[Journal Article] Fatty acid-binding protein 7 triggers α-synuclein oligomerization in glial cells and oligodendrocytes associated with oxidative stress2021
- Author(s)
  Cheng An、Wang Yi-fei、Shinoda Yasuharu、Kawahata Ichiro、Yamamoto Tetsunori、Jia Wen-bin、Yamamoto Hanae、Mizobata Tomohiro、Kawata Yasushi、Fukunaga Kohji
- Journal Title
  
  Acta Pharmacologica Sinica
  
  Volume: 43 Pages: 552-562
- DOI
  10.1038/s41401-021-00675-8
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K06513, KAKENHI-PROJECT-19K07097, KAKENHI-PROJECT-19H03406
[Journal Article] 大腸菌の「環境応答型」分子シャペロンが見せる可逆線維化反応の解析2021
- Author(s)
  中田結衣，宮脇史織，東末剛己，溝端知宏
- Journal Title
  
  月刊細胞
  
  Volume: 53 Pages: 565-568
- NAID
  40022675992
- Data Source
  KAKENHI-PROJECT-19K06513
[Journal Article] Dopamine D2 Long Receptors Are Critical for Caveolae-Mediated α-Synuclein Uptake in Cultured Dopaminergic Neurons.2021
- Author(s)
  Kawahata I, Sekimori T, Wang H, Wang Y, Sasaoka T, Bousset L, Melki R, Mizobata T, Kawata Y, Fukunaga K.
- Journal Title
  
  Biomedicines
  
  Volume: 9 Issue: 1 Pages: 49-49
- DOI
  10.3390/biomedicines9010049
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18H02540, KAKENHI-PROJECT-19H03406, KAKENHI-PROJECT-16H06276, KAKENHI-PROJECT-19K06513, KAKENHI-PROJECT-19K07097
[Journal Article] An α-synuclein decoy peptide prevents cytotoxic α-synuclein aggregation caused by fatty acid binding protein 32021
- Author(s)
  Fukui N, Yamamoto H, Miyabe M, Aoyama Y, Hongo K, Mizobata T, Kawahata I, Yabuki Y, Shinoda Y, Fukunaga K, Kawata Y.
- Journal Title
  
  Journal of Biological Chemistry
  
  Volume: Apr 13 Pages: 100663-100663
- DOI
  10.1016/j.jbc.2021.100663
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19H03406, KAKENHI-PROJECT-19K06513, KAKENHI-PROJECT-19K07097
[Journal Article] Anthocyanin suppresses the toxicity of Aβ deposits in in vitro and in vivo models of Alzheimer's disease2016
- Author(s)
  Yamakawa, M. Y. Uchino, K. Watanabe, Y. Adachi, T. Nakanishi, M. Ichino, H. Hongo, K. Mizobata, T. Kobayashi, S. Nakashima, K. Kawata, Y.
- Journal Title
  
  Nutr Neurosci
  
  Volume: 19 Pages: 32-42
- DOI
  10.1179/1476830515y.0000000042
- Peer Reviewed / Acknowledgement Compliant / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25440026, KAKENHI-PROJECT-25440027, KAKENHI-PROJECT-16K09719
[Journal Article] Structural basis of Cu, Zn-superoxide dismutase amyloid fibril formation involves interaction of multiple peptide core regions.2016
- Author(s)
  Ida, M. Ando, M. Adachi, M. Tanaka, A. Machida, K. Hongo, K. Mizobata, T. Yamakawa, M. Y. Watanabe, Y. Nakashima, K. Kawata, Y.
- Journal Title
  
  J Biochem
  
  Volume: 159 Pages: 247-260
- DOI
  10.1093/jb/mvv091
- Peer Reviewed / Acknowledgement Compliant / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25440026, KAKENHI-PROJECT-25440027, KAKENHI-PROJECT-25461315, KAKENHI-PROJECT-16K09719
[Journal Article] Probing the dynamic process of encapsulation in Escherichia coli GroEL2013
- Author(s)
  Mizuta, T. Ando, K. Uemura, T. Kawata, Y. Mizobata, T.
- Journal Title
  
  PLoS One
  
  Volume: 8
- DOI
  10.1371/journal.pone.0078135
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25440026
[Journal Article] Bilberry anthocyanins neutralize the cytotoxicity of co-chaperonin GroES fibrillation intermediates2013
- Author(s)
  Hisanori Iwasa, Hiroshi Kameda, Naoya Fukui, Sakiho Yoshida, Kunihiro Hongo, Tomohiro Mizobata, Saori Kobayashi, and Yasushi Kawata
- Journal Title
  
  Biochemistry
  
  Volume: 52 Pages: 9202-9211
- DOI
  10.1021/bi401135j
- Peer Reviewed
- Data Source
  KAKENHI-PUBLICLY-24113716, KAKENHI-PROJECT-25440027
[Journal Article] Varied effects of Pyrococcus furiosus prefoldin and P. furiosus chaperonin on the refolding reactions of substrate proteins2012
- Author(s)
  Kunihiro Hongo, Hiroshi Itai, Tomohiro Mizobata, and Yasushi Kawata
- Journal Title
  
  J. Biochem
  
  Volume: 151(4) Pages: 383-390
- NAID
  10031166077
- Data Source
  KAKENHI-PROJECT-21570113
[Journal Article] Suppression of Sup35 amyloid fibril formation by group II chaperonin from Thermoplasma Acidophilum2012
- Author(s)
  Kentaro Noi, Aya Kitamura, Hidenori Hirai, Kunihiro Hongo, Toshihiko Sakurai, Tomohiro Mizobata, and Yasushi Kawata
- Journal Title
  
  American J. Mol. Biol
  
  Volume: (in press)
- Data Source
  KAKENHI-PROJECT-21570113
[Journal Article] Suppression of Sup35 amyloid fibril formation by group II chaperonin from Thermoplasma acidophilum2012
- Author(s)
  Noi, K., Kitamura, A., Hirai, H.,Hongo, K., Sakurai, T., Mizobata, T., and Kawata, Y
- Journal Title
  
  Am. J. Mol. Biol
  
  Volume: 2 Pages: 265-375
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22570119
[Journal Article] Role of C-terminal negative charges and tyrosine residues in fibril formation of alpha-synuclein2012
- Author(s)
  Izawa, Y., Tateno, H., Kameda, H., Hirakawa, K., Hato, K., Yagi, H.,Hongo, K., Mizobata, T., and Kawata,Y
- Journal Title
  
  Brain and behavior
  
  Volume: 2 Pages: 595-605
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22570119
[Journal Article] Varied effects of Pyrococcus furiosus prefoldin and P2012
- Author(s)
  Hongo, K., Itai, H., Mizobata, T., and Kawata, Y
- Journal Title
  
  furiosus chaperonin on the refolding reactions of substrate proteins
  
  Volume: 151 Pages: 383-390
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22570119
[Journal Article] Probing the functional mechanism of Escherichia coli GroEL using circular permutation2011
- Author(s)
  Mizobata, T., Uemura, T., Isaji, K.,Hirayama, T., Hongo, K., and Kawata,Y
- Journal Title
  
  PLoS One
  
  Volume: 6
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22570119
[Journal Article] Covalent structural changes in unfolded GroES that lead to amyloid fibril formation detected by NMR : Insight into intrinsically disordered proteins2011
- Author(s)
  Hisanori Iwasa, Shunsuke Meshitsuka, Kunihiro Hongo, Tomohiro Mizobata, and Yasushi Kawata
- Journal Title
  
  J. Biol. Chem
  
  Volume: 286(24) Pages: 21796-21805
- Data Source
  KAKENHI-PROJECT-21570113
[Journal Article] Covalent structural changes in unfolded GroES that lead to amyloid fibril formation detected by NMR: insight into intrinsically disordered proteins2011
- Author(s)
  Iwasa, H., Meshitsuka, S., Hongo,K., Mizobata, T., and Kawata, Y.
- Journal Title
  
  J. Biol. Chem
  
  Volume: 286 Pages: 21796-21805
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22570119
[Journal Article] Probing the Functional Mechanism of Escherichia coli GroEL Using Circular Permutation2011
- Author(s)
  Tomohiro Mizobata, Tatsuya Uemura, Kazuhiro Isaji, Takuma Hirayama, Kunihiro Hongo, and Yasushi Kawata
- Journal Title
  
  PLoS ONE
  
  Volume: 6(10)
- Data Source
  KAKENHI-PROJECT-21570113
[Journal Article] Covalent structural changes in unfolded GroES that lead to amyloid fibril formation detected by NMR : insight into intrinsically disordered proteins2011
- Author(s)
  Hisanori Iwasa, Shunsuke Meshitsuka, Kunihiro Hongo, Tomohiro Mizobata, Yasushi Kawata
- Journal Title
  
  The Journal of Biological Chemistry
  
  Volume: 286 Pages: 21796-21805
- DOI
  10.1074/jbc.m111.228445
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21570113, KAKENHI-PUBLICLY-22113513, KAKENHI-PROJECT-22570119
[Journal Article] Probing the functional mechanism of Escherichia coli GroEL using circular permutation2011
- Author(s)
  Tomohiro Mizobata, Tatsuya Uemura, Kazuhiro Isaji, Takuma Hirayama, Kunihiro Hongo, Yasushi Kawata
- Journal Title
  
  PLoS One
  
  Volume: 6
- DOI
  10.1371/journal.pone.0026462
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21570113, KAKENHI-PUBLICLY-22020025, KAKENHI-PROJECT-22570119
[Journal Article] Isolation of short peptide fragments from alpha-synuclein fibril core identifies a residue important for fibril nucleation: a possible implication for diagnostic applications2010
- Author(s)
  Yagi, H., Takeuchi, H., Ogawa, S., Ito,N., Sakane, I., Hongo, K., Mizobata,T., Goto, Y., and Kawata, Y
- Journal Title
  
  Biochim. Biophys. Acta
  
  Volume: 1804 Pages: 2077-2087
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22570119
[Journal Article] Isolation of short peptide fragments from□-synuclein fibril core identifies a residue important for fibril nucleation : A possible implication for diagnostic applications2010
- Author(s)
  Hisashi Yagi, Hideki Takeuchi, Shiho Ogawa, Naomi Ito, Isao Sakane, Kunihiro Hongo, Tomohiro Mizobata, Yuji Goto, and Yasushi Kawata
- Journal Title
  
  Biochim. Biophys. Acta/Proteins and Proteomics
  
  Volume: 1804(10) Pages: 2077-2087
- Data Source
  KAKENHI-PROJECT-21570113
[Journal Article] ヤヌスの二つの顔:大腸菌シャペロニンGroELの頂上ドメインに関する最近の研究2010
- Author(s)
  溝端知宏, 河田康志
- Journal Title
  
  生化学
  
  Volume: 82 Pages: 612-617
- NAID
  10026607651
- Data Source
  KAKENHI-PROJECT-22570119
[Journal Article] 「タンパク質のフォールディングを補助するシャペロニンの構造と働き」2010
- Author(s)
  溝端知宏,河田康志
- Journal Title
  
  鳥取大学大学院工学研究科/工学部研究報告
  
  Volume: 41 Pages: 29-35
- Data Source
  KAKENHI-PROJECT-22570119
[Journal Article] タンパク質のフォールディングを補助するシャペロニンの構造と働き2010
- Author(s)
  溝端知宏, 河田康志
- Journal Title
  
  鳥取大学大学院工学研究科/工学部研究報告(紀要)
  
  Volume: 41 Pages: 29-35
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21570113
[Journal Article] タンパク質のフォールディングを補助するシャペロニンの構造と働き2010
- Author(s)
  溝端知宏, 河田康志
- Journal Title
  
  鳥取大学大学院工学研究科/工学部研究報告
  
  Volume: 41 Pages: 29-35
- Data Source
  KAKENHI-PROJECT-22570119
[Journal Article] Isolation of short peptide fragments from α-synuclein fibril core identifies a residue important for fibril nucleation : A possible implication for diagnostic applications2010
- Author(s)
  Hisashi Yagi, Hideki Takeuchi, Shiho Ogawa, Naomi Ito, Isao Sakane, Kunihiro Hongo, Tomohiro Mizobata, Yuji Goto, Yasushi Kawata
- Journal Title
  
  Biochim.Biophys.Acta/Proteins and Proteomics
  
  Volume: 1804 Pages: 2077-2087
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21570113
[Journal Article] Gly192 at hinge 2 site in the chaperonin GroEL plays a pivotal role in the dynamic apical domain movement that leads to GroES binding and efficient encapsulation of substrate proteins2009
- Author(s)
  Kodai Machida, Ryoko Fujiwara, Tatsuhide Tanaka, Isao Sakane, Kunihiro Hongo, Tomohiro Mizobata, and Yasushi Kawata
- Journal Title
  
  Biochim. Biophys. Acta/Proteins and Proteomics
  
  Volume: 1794(9) Pages: 1344-1354
- Data Source
  KAKENHI-PROJECT-21570113
[Journal Article] A potentially versatile nucleotide hydrolysis activity of group II chaperonin monomers from Thermoplasma acidophilum2009
- Author(s)
  Kentaro Noi, Hidenori Hirai, Kunihiro Hongo, Tomohiro Mizobata, and Yasushi Kawata
- Journal Title
  
  Biochemistry
  
  Volume: 48(40) Pages: 9405-9415
- Data Source
  KAKENHI-PROJECT-21570113
[Journal Article] Gly192 at hinge 2 site in the chaperonin GroEL plays a pivotal role in the dynamic apical domain movement that leads to GroES binding and efficient encapsulation of substrate proteins2009
- Author(s)
  Kodai Machida, Ryoko Fujiwara, Tatsuhide Tanaka, Isao Sakane, Kunihiro Hongo, Tomohiro Mizobata, Yasushi Kawata
- Journal Title
  
  Biochim.Biophys.Acta/Proteins and Proteomics 1794
  
  Pages: 1344-1354
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21570113
[Journal Article] Mechanical unfolding of covalently linked GroES : Evidence of structural subunit intermediates2009
- Author(s)
  Isao Sakane, Kunihiro Hongo, Tomohiro Mizobata, Yasushi Kawata
- Journal Title
  
  Protein Science 18
  
  Pages: 252-257
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21570113
[Journal Article] A potentially versatile nucleotide hydrolysis activity of group II chaperonin monomers from Thermoplasma acidophilum2009
- Author(s)
  Kentaro Noi, Hidenori Hirai, Kunihiro Hongo, Tomohiro Mizobata, Yasushi Kawata
- Journal Title
  
  Biochemistry 48
  
  Pages: 9405-9415
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21570113
[Journal Article] A Novel ATP/ADP Hydrolysis Activity of Hyperthermostable Group II Chaperonin in the Presence of Cobalt or Manganese Ion2006
- Author(s)
  Kunihiro Hongo, Hidenori Hirai, Chisato Uemura, Shujiro Ono, Junjiro Tsunemi, Takashi Higurashi, Tomohiro Mizobata, Yasushi Kawata
- Journal Title
  
  FEBS Letters 580
  
  Pages: 34-40
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15370047
[Journal Article] Multiple structural transitions of the GroEL subunit are sensitive to intermolecular interactions with cochaperonin and refolding polypeptide2006
- Author(s)
  Tatsunari Yoshimi, Kunihiro Hongo, Tomohiro Mizobata, Yasushi Kawata
- Journal Title
  
  Journal of Biochemistry 139・3
  
  Pages: 407-419
- NAID
  10018846460
- Data Source
  KAKENHI-PROJECT-14037241
[Journal Article] Multiple structural transitions of the GroEL subunit are sensitive to intermolecular interactions with cochaperonin and refolding polypeptide2006
- Author(s)
  Tatsunari Yoshimi, Kunihiro Hongo, Tomohiro Mizobata, Yasushi Kawata
- Journal Title
  
  Journal of Biochemistry (印刷中)
- NAID
  10018846460
- Data Source
  KAKENHI-PROJECT-14037241
[Journal Article] Amyloid-like Fibril Formation of Co-chaperonin GroES : Nucleation and Extension Prefer Different Degrees of Molecular Compactness2005
- Author(s)
  Takashi Higurashi, Hisashi Yagi, Tomohiro Mizobata, Yasushi Kawata
- Journal Title
  
  Journal of Molecular Biology 351(5)
  
  Pages: 1057-1069
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15370047
[Journal Article] Amyloid-like Fibril Formation of Co-chaperonin GroES : Nucleation and Extension Prefer Different Degrees of Molecular Compactness2005
- Author(s)
  Takashi Higurashi, Hisashi Yagi, Tomohiro Mizobata, Yasushi Kawata
- Journal Title
  
  Journal of Molecular Biology 351・5
  
  Pages: 1057-1069
- Data Source
  KAKENHI-PROJECT-14037241
[Journal Article] Amyloid-like Fibril Formation of Co-chaperonin GroES : Nucleation and Extension Prefer Different Degrees of Molecular Compactness2005
- Author(s)
  Takashi Higurashi, Hisashi Yagi, Tomohiro Mizobata, Yasushi Kawata
- Journal Title
  
  J. Mol. Biol. 351・5
  
  Pages: 1057-1069
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15370047
[Journal Article] Amyloid-like Fibril Formation of Co-chaperonin GroES : Nucleation and Extension Prefer Different Degrees of Molecular Compactness2005
- Author(s)
  Takashi Higurashi, Hisashi Yagi, Tomohiro Mizobata, Yasushi Kawata
- Journal Title
  
  Journal of Molecular Biology 351・5
  
  Pages: 1057-1069
- Data Source
  KAKENHI-PROJECT-15370047
[Journal Article] Amyloid Fibril Formation of a-Synuclein is Accelerated by Preformed Amyloid Seeds of Other Proteins : Implications for the Mechanism of Transmissible Conformational Diseases2005
- Author(s)
  Hisashi Yagi, Eiko Kusaka, Kunihiro Hongo, Tomohiro Mizobata, Yasushi Kawata
- Journal Title
  
  Journal of Biological Chemistry 280(46)
  
  Pages: 38609-38616
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15370047
[Journal Article] Amyloid Fibril Formation of α-Synuclein is Accelerated by Preformed Amyloid Seeds of Other Proteins : Implications for the Mechanism of Transmissible Conformational Diseases2005
- Author(s)
  Hisashi Yagi, Eiko Kusaka, Kunihiro Hongo, Tomohiro Mizobata, Yasushi Kawata
- Journal Title
  
  Journal of Biological Chemistry 280・46
  
  Pages: 38609-38616
- Data Source
  KAKENHI-PROJECT-14037241
[Journal Article] Amyloid Fibril Formation of α-Synuclein is Accelerated by Preformed Amyloid Seeds of Other Proteins: Implications for the Mechanism of Transmissible Conformational Diseases2005
- Author(s)
  Hisashi Yagi, Eiko Kusaka, Kunihiro Hongo, Tomohiro Mizobata, Yasushi Kawata
- Journal Title
  
  Journal of Biological Chemistry 280(46)
  
  Pages: 38609-38616
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14037241
[Journal Article] Amyloid Fibril Formation of a-Synuclein is Accelerated by Preformed Amyloid Seeds of Other Proteins : Implications for the Mechanism of Transmissible Conformational Diseases2005
- Author(s)
  Hisashi Yagi, Eiko Kusaka, Kunihiro Hongo, Tomohiro Mizobata, Yasushi Kawata
- Journal Title
  
  Journal of Biological Chemistry 280・46
  
  Pages: 38609-38616
- Data Source
  KAKENHI-PROJECT-15370047
[Journal Article] Stopped-Flow Fluorescence Analysis of the Conformational Changes in the GroEL Apical Domain: Relationships between Movements in the Apical Domain and the Quaternary Structure of GroEL2004
- Author(s)
  Masaaki Taniguchi, Tatsunari Yoshimi, Kunihiro Hongo, Tomohiro Mizobata, Yasushi Kawata
- Journal Title
  
  Journal of Biological Chemistry 279(16)
  
  Pages: 16368-16376
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14037241
[Journal Article] Stopped-Flow Fluorescence Analysis of the Conformational Changes in the GroEL Apical Domain : Relationships between Movements in the Apical Domain and the Quaternary Structure of GroEL2004
- Author(s)
  Masaaki Taniguchi, Tatsunari Yoshimi, Kunihiro Hongo, Tomohiro Mizobata, Yasushi Kawata
- Journal Title
  
  Journal of Biological Chemistry 279(16)
  
  Pages: 16368-16376
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15370047
[Journal Article] Structural Stability and Solution Structure of Chaperonin GroES Heptamer Studied by Synchrotron Small-Angle X-Ray Scattering2003
- Author(s)
  Takashi Higurashi, Yuzuru Hiragi, Kaoru Ichimura, Yasutaka Seki, Kunitsugu Soda, Tomohiro Mizobata, Yasushi Kawata
- Journal Title
  
  Journal of Molecular Biology 333(3)
  
  Pages: 605-620
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15370047
[Journal Article] Structural Stability and Solution Structure of Chaperonin GroES Heptamer Studied by Synchrotron Small-Angle X-Ray Scattering2003
- Author(s)
  Takashi Higurashi, Yuzuru Hiragi, Kaoru Ichimura, Yasutaka Seki, Kunitsugu Soda, Tomohiro Mizobata, Yasushi Kawata
- Journal Title
  
  Journal of Molecular Biology 333(3)
  
  Pages: 605-620
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14037241
[Patent] アミロイド線維伸張ペプチド2009
- Inventor(s)
  河田康志,溝端知宏,本郷邦広,武内英樹
- Industrial Property Rights Holder
  鳥取大学
- Industrial Property Number
  2009-277681
- Filing Date
  2009-12-07
- Data Source
  KAKENHI-PROJECT-21570113
[Patent] アミロイド線維伸張ペプチド2009
- Inventor(s)
  河田康志, 溝端知宏, 本郷邦広, 武内英樹
- Industrial Property Rights Holder
  鳥取大学
- Industrial Property Number
  2009-277681
- Filing Date
  2009-12-07
- Data Source
  KAKENHI-PROJECT-21570113
[Presentation] 環境応答型分子シャペロンHdeBの可逆線維化反応2021
- Author(s)
  北崎悠人，中田結衣，上原梨那，本郷邦広，河田康志，溝端知宏
- Organizer
  第94回日本生化学会大会
- Data Source
  KAKENHI-PROJECT-19K06513
[Presentation] 真核細胞内におけるαシヌクレインと脂肪酸結合タンパク質FABP3の相互作用に関する研究2021
- Author(s)
  宮部　萌，山本英絵，福井　直也，本郷　邦広，溝端　知宏，福永　浩司，河田　康志
- Organizer
  第21回日本蛋白質科学会年会
- Data Source
  KAKENHI-PROJECT-19K06513
[Presentation] 酸感受性分子シャペロンHdeAの不活性化を誘発するペプチド配列の検索2021
- Author(s)
  古川敦智，本郷邦広，河田康志，溝端知宏
- Organizer
  第94回日本生化学会大会
- Data Source
  KAKENHI-PROJECT-19K06513
[Presentation] 酸感受性分子シャペロンHdeAの可逆的アミロイド線維形成と金属イオンに関する研究2021
- Author(s)
  東末剛己，宮脇史織，本郷邦広，溝端知宏
- Organizer
  第94回日本生化学会大会
- Data Source
  KAKENHI-PROJECT-19K06513
[Presentation] HdeBの線維化およびその構造特性2020
- Author(s)
  上原梨那、中田結衣、本郷邦広、河田康志、溝端知宏
- Organizer
  第20回　日本蛋白質科学会年会
- Data Source
  KAKENHI-PROJECT-19K06513
[Presentation] 環境応答型分子シャペロンが見せる可逆線維化反応とその応用2019
- Author(s)
  溝端知宏
- Organizer
  日本ペプチド学会第26回ペプチドフォーラム
- Invited
- Data Source
  KAKENHI-PROJECT-19K06513
[Presentation] 大腸菌ペリプラズム分子シャペロンHdeAが見せる可逆線維化反応の構造多型2019
- Author(s)
  宮脇史織，本郷邦広，河田康志，溝端知宏
- Organizer
  第19回日本蛋白質科学会年会・第71回日本細胞生物学会大会　合同年次大会
- Data Source
  KAKENHI-PROJECT-19K06513
[Presentation] 酸変性に誘発される大腸菌ペリプラズムHdeAの分子シャペロン機能と可逆線維化2019
- Author(s)
  溝端知宏
- Organizer
  第 92 回日本生化学会大会
- Data Source
  KAKENHI-PROJECT-19K06513
[Presentation] The structural landscape of the periplasmic molecular chaperones HdeA and HdeB: Acid induced activation of molecular chaperone activity and fibrillar aggregation2019
- Author(s)
  Tomohiro Mizobata
- Organizer
  The 10th KRIBB Asia-Pacific IDP Symposium
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K06513
[Presentation] アントシアニンによる家族性ALS原因タンパク質SOD1 G93Aのアミロイド線維形成抑制2015
- Author(s)
  安藤瑞歩、本郷邦広、溝端知宏、小林沙織、河田康志
- Organizer
  第38回日本分子生物学会年会、第88回日本生化学会大会合同大会
- Place of Presentation
  神戸ポートアイランド
- Year and Date
  2015-12-01
- Data Source
  KAKENHI-PROJECT-25440026
[Presentation] アントシアニンによる家族性ALS原因タンパク質SOD1 G93Aのアミロイド線維形成抑制2015
- Author(s)
  安藤瑞歩，本郷邦広，溝端知宏，小林沙織，河田康志
- Organizer
  BMB2015:第３８回日本分子生物学会年会，第８８回日本生化学会大会
- Place of Presentation
  神戸市
- Year and Date
  2015-12-01
- Data Source
  KAKENHI-PROJECT-25440027
[Presentation] Inhibition mechanism of anthocyanin for Alpha-synuclein amyloid fibril formation2015
- Author(s)
  Seki Lee, Kazuya Hirakawa, Kunihiro Hongo, Tomohiro Mizobata, Yasushi Kawata
- Organizer
  第15回日本蛋白質科学会年会
- Place of Presentation
  徳島市あわぎんホール
- Year and Date
  2015-06-25
- Data Source
  KAKENHI-PROJECT-25440026
[Presentation] アントシアニンによるアルファークリスタリン蛋白質の凝集抑制2015
- Author(s)
  下田香、山下智、本郷邦広、溝端知宏、小林沙織、河田康志
- Organizer
  第38回日本分子生物学会年会、第88回日本生化学会大会合同大会
- Place of Presentation
  神戸ポートアイランド
- Year and Date
  2015-12-02
- Data Source
  KAKENHI-PROJECT-25440026
[Presentation] Stopped-Flow characterisation of a mutant chaperonin GroEL with a CXXC motif2015
- Author(s)
  Yoko Shima, Masashi Ikeda, Kunihiro Hongo, Yasushi Kawata, Tomohiro Mizobata
- Organizer
  第15回日本蛋白質科学会年会
- Place of Presentation
  徳島市あわぎんホール
- Year and Date
  2015-06-25
- Data Source
  KAKENHI-PROJECT-25440026
[Presentation] Effect of GroEL Apical Domain on the Aggregation of alpha-Synuclein2015
- Author(s)
  Bimlesh Ojha, Kunihiro Hongo, Tomohiro Mizobata, Yasushi Kawata
- Organizer
  第15回日本蛋白質科学会年会
- Place of Presentation
  徳島市あわぎんホール
- Year and Date
  2015-06-25
- Data Source
  KAKENHI-PROJECT-25440026
[Presentation] 強制テザリング法によるシャペロニンGroELの機能解析2015
- Author(s)
  福井直也、本郷邦広、溝端知宏、河田康志
- Organizer
  第38回日本分子生物学会年会、第88回日本生化学会大会合同大会
- Place of Presentation
  神戸ポートアイランド
- Year and Date
  2015-12-02
- Data Source
  KAKENHI-PROJECT-25440026
[Presentation] ALS発症原因タンパク質SOD1の構造安定性とアミロイド線維形成機構2015
- Author(s)
  井田昌孝、安藤瑞歩、本郷邦広、溝端知宏、河田康志
- Organizer
  第38回日本分子生物学会年会、第88回日本生化学会大会合同大会
- Place of Presentation
  神戸ポートアイランド
- Year and Date
  2015-12-02
- Data Source
  KAKENHI-PROJECT-25440026
[Presentation] ALS発症原因タンパク質SOD1の構造安定性とアミロイド線維形成機構2015
- Author(s)
  井田昌孝，安藤瑞歩，本郷邦広，溝端知宏，河田康志
- Organizer
  BMB2015:第３８回日本分子生物学会年会，第８８回日本生化学会大会
- Place of Presentation
  神戸市
- Year and Date
  2015-12-01
- Data Source
  KAKENHI-PROJECT-25440027
[Presentation] ATPの加水分解が引き起こすGroELサブユニットの動的構造変化2015
- Author(s)
  藤井豊、本郷邦広、河田康志、溝端知宏
- Organizer
  第38回日本分子生物学会年会、第88回日本生化学会大会合同大会
- Place of Presentation
  神戸ポートアイランド
- Year and Date
  2015-12-03
- Data Source
  KAKENHI-PROJECT-25440026
[Presentation] 家族性ALS原因タンパク質SOD1 G93A変異体のアミロイド線維形成機構の解明とポリフェノールVMAによる線維形成抑制効果の検証2014
- Author(s)
  安藤瑞歩, 井田昌孝, 足立誠幸, 本郷邦広, 溝端知宏, 小林沙織, 山川（吉田）三穂, 渡辺保裕, 中島健二, 河田康志
- Organizer
  第87回日本生化学会大会
- Place of Presentation
  京都国際会館
- Year and Date
  2014-10-17
- Data Source
  KAKENHI-PROJECT-25440026
[Presentation] 化学修飾による大腸菌GroEL円順列変異体CP376の機能改変2014
- Author(s)
  栗本成正, 薬師寺佑典, 伊佐治算浩, 水田敏史, 本郷邦広, 河田康志, 溝端知宏
- Organizer
  第87回日本生化学会大会
- Place of Presentation
  京都国際会館
- Year and Date
  2014-10-17
- Data Source
  KAKENHI-PROJECT-25440026
[Presentation] マウス由来プリオンタンパク質のアミロイド線維形成と細胞毒性2014
- Author(s)
  川添亜沙美, 藤井冴郁, 森本悠介, 本郷邦広, 溝端知宏, 小林沙織, 河田康志
- Organizer
  第87回日本生化学会大会
- Place of Presentation
  京都国際会館
- Year and Date
  2014-10-17
- Data Source
  KAKENHI-PROJECT-25440026
[Presentation] αシヌクレイン蛋白質のアミロイド線維核部位に存在するPhe94とその周辺残基の線維形成における役割解明2014
- Author(s)
  齋木美裕, 伊藤有未, 本郷邦広, 溝端知宏, 河田康志
- Organizer
  第87回日本生化学会大会
- Place of Presentation
  京都国際会館
- Year and Date
  2014-10-17
- Data Source
  KAKENHI-PROJECT-25440026
[Presentation] αシヌクレイン蛋白質のアミロイド線維核部位に存在するPhe94とその周辺残基の線維形成おける役割解明2014
- Author(s)
  齋木美裕，伊藤有未, 本郷邦広, 溝端知宏, 河田康志
- Organizer
  第８７回日本生化学会大会
- Place of Presentation
  京都市
- Year and Date
  2014-10-17
- Data Source
  KAKENHI-PROJECT-25440027
[Presentation] シャペロニンGroELのHinge2部位Gly192残基の変異体機能解析2013
- Author(s)
  福井直也，荒木紀帆，本郷邦広，溝端知宏，河田康志
- Organizer
  第13回日本蛋白質科学会年会
- Place of Presentation
  とりぎん文化会館(鳥取市)
- Data Source
  KAKENHI-PROJECT-25440026
[Presentation] クリスタリン蛋白質の凝集抑制効果に関する研究2013
- Author(s)
  山下智，内島諒子，本郷邦広，溝端知宏，小林沙織，河田康志
- Organizer
  第13回日本蛋白質科学会年会
- Place of Presentation
  鳥取，とりぎん文化会館
- Data Source
  KAKENHI-PROJECT-25440027
[Presentation] パーキンソン病原因蛋白質α-synucleinアミロイド線維のアントシアニンによる分解機構2013
- Author(s)
  平川和哉，岩佐尚徳，本郷邦広，溝端知宏，小林沙織，河田康志
- Organizer
  第13回日本蛋白質科学会年会
- Place of Presentation
  鳥取，とりぎん文化会館
- Data Source
  KAKENHI-PROJECT-25440027
[Presentation] αシヌクレインのアミロイド線維形成を抑制するキノコ由来ケミカルシャペロンの探索2013
- Author(s)
  亀田啓, 櫻井敏彦, 本郷邦広, 溝端知宏, 河田康志
- Organizer
  第13回日本蛋白質科学会年会
- Place of Presentation
  鳥取，とりぎん文化会館
- Data Source
  KAKENHI-PROJECT-25440027
[Presentation] シャペロニンGroEL頂上ドメインの反応サイクルにおける動きと役割2013
- Author(s)
  溝端知宏
- Organizer
  第13回日本蛋白質科学会年会
- Place of Presentation
  とりぎん文化会館(鳥取市)
- Invited
- Data Source
  KAKENHI-PROJECT-25440026
[Presentation] 大腸菌GroELの機能発現における頂上ドメインの動きと役割2012
- Author(s)
  溝端知宏
- Organizer
  大阪大学蛋白質研究所セミナー「分子シャペロンの機能発現の新展開と細胞制御」
- Place of Presentation
  大阪大学蛋白質研究所
- Year and Date
  2012-11-15
- Data Source
  KAKENHI-PROJECT-22570119
[Presentation] Elucidating the Molecular Mechanism of Chaperonin-facilitated Protein Folding2012
- Author(s)
  Mizobata Tomohiro
- Organizer
  2nd Seminar on Green Sustainable Chemistry in Tottori
- Place of Presentation
  鳥取大学
- Year and Date
  2012-12-03
- Data Source
  KAKENHI-PROJECT-22570119
[Presentation] 円順列変異体GroELを用いたシャペロニンの機能解析2012
- Author(s)
  溝端知宏
- Organizer
  第12回日本蛋白質科学会年会
- Place of Presentation
  名古屋国際会議場
- Year and Date
  2012-06-20
- Data Source
  KAKENHI-PROJECT-22570119
[Presentation] Using circular permutation to probe various characteristics of E. coli GroEL2012
- Author(s)
  Mizobata Tomohiro
- Organizer
  2012 Meeting on Molecular Chaperones and Stress Responses
- Place of Presentation
  Cold Spring Harbor Laboratory, New York
- Year and Date
  2012-05-03
- Data Source
  KAKENHI-PROJECT-22570119
[Presentation] GroEL円順列変異体CP254の構造・機能相関解析2011
- Author(s)
  岡田拓也, 植木裕士, 植村達也, 本郷邦広, 河田康志, 溝端知宏
- Organizer
  第84回日本生化学会大会
- Place of Presentation
  京都
- Year and Date
  2011-09-23
- Data Source
  KAKENHI-PROJECT-21570113
[Presentation] αシヌクレイン蛋白質のアミロイド線維核部位に位置するPhe 94の線維形成における役割2011
- Author(s)
  伊藤有未, 武内英樹, 本郷邦広, 溝端知宏, 河田康志
- Organizer
  第11回日本蛋白質科学会
- Place of Presentation
  吹田
- Year and Date
  2011-06-09
- Data Source
  KAKENHI-PROJECT-21570113
[Presentation] アントシアニンによる神経変性病原因タンパク質のアミロイド線維形成抑制に関するin vitroとin vivo研究2011
- Author(s)
  河田康志, 鎌田光博, 渡辺保裕, 小林真菜, 吉田早穂, 田村哲也, 本郷邦広, 溝端知宏, 三浦典正, 中島健二, 小林沙織
- Organizer
  第84回日本生化学会大会
- Place of Presentation
  京都
- Year and Date
  2011-09-24
- Data Source
  KAKENHI-PROJECT-21570113
[Presentation] シャペロニンGroELの機能的構造変化の中心点Hinge II部位のGly192残基の変異体機能解析2011
- Author(s)
  荒木紀帆, 和田翼, 町田広大, 本郷邦広, 溝端知宏, 河田康志
- Organizer
  第84回日本生化学会大会
- Place of Presentation
  京都
- Year and Date
  2011-09-23
- Data Source
  KAKENHI-PROJECT-21570113
[Presentation] シャペロニン本来の基質蛋白質の同定2011
- Author(s)
  石橋利嗣, 本郷邦広, 溝端知宏, 河田康志
- Organizer
  第11回日本蛋白質科学会年会
- Place of Presentation
  吹田
- Year and Date
  2011-06-07
- Data Source
  KAKENHI-PROJECT-21570113
[Presentation] 円順列変異型GroELの機能的性質とタンパク質工学2011
- Author(s)
  溝端知宏
- Organizer
  第52回日本生化学会中国・四国支部例会
- Place of Presentation
  広島大学広仁会館
- Year and Date
  2011-05-13
- Data Source
  KAKENHI-PROJECT-22570119
[Presentation] 円順列変異型GroELの機能的性質とタンパク質工学2011
- Author(s)
  溝端知宏
- Organizer
  第52回日本生化学会中国・四国支部例会
- Place of Presentation
  広島大学広仁会館
- Year and Date
  2011-05-13
- Data Source
  KAKENHI-PROJECT-22570119
[Presentation] αシヌクレイン蛋白質のアミロイド線維核部位に位置するPhe 94の線維形成における役割2011
- Author(s)
  伊藤有未, 武内英樹, 本郷邦広, 溝端知宏, 河田康志
- Organizer
  第11回日本蛋白質科学会年会
- Place of Presentation
  吹田
- Year and Date
  2011-06-09
- Data Source
  KAKENHI-PROJECT-21570113
[Presentation] Modulation of the Altered Functional Characteristics of Circularly Permuted GroEL through the Introduction of Disulfide Bonds2010
- Author(s)
  Mizobata Tomohiro
- Organizer
  The 4th International Symposium on "Molecular Science of Fluctuations toward Biological Functions"
- Place of Presentation
  Piazza Omi, Shiga Japan
- Year and Date
  2010-11-30
- Data Source
  KAKENHI-PROJECT-22570119
[Presentation] Detection of the conformational change by NMR that leads to GroES amyloid fibril formation from a disordered state2010
- Author(s)
  Hisanori Iwasa, Shunsuke Meshitsuka, Kunihiro Hongo, Tomohiro Mizobata, and Yasushi Kawata
- Organizer
  The 3^<rd> International Symposium on Protein Community
- Place of Presentation
  Nara
- Year and Date
  2010-09-14
- Data Source
  KAKENHI-PROJECT-21570113
[Presentation] Rearrangement reaction at Asn-Gly of GroES enhances a conformation that leads to amyloid fibril formation in early step2010
- Author(s)
  Hisanori Iwasa, Shunsuke Meshitsuka, Kunihiro Hongo, Tomohiro Mizobata, and Yasushi Kawata
- Organizer
  The 24th Protein Society Meeting
- Place of Presentation
  San Diego
- Year and Date
  2010-08-02
- Data Source
  KAKENHI-PROJECT-21570113
[Presentation] GroESのアミロイド線維形成の初期過程には核部位直前のアミノ酸配列が関与する2010
- Author(s)
  岩佐尚徳, 飯塚舜介, 本郷邦広, 溝端知宏, 河田康志
- Organizer
  第10回日本蛋白質科学会年会
- Place of Presentation
  札幌
- Year and Date
  2010-06-16
- Data Source
  KAKENHI-PROJECT-21570113
[Presentation] NMRによるGroESアミロイド線維中間体の形成メカニズムと植物性低分子化合物による阻害効果の評価2010
- Author(s)
  岩佐尚徳, 吉田早穂, 亀田啓, 飯塚舜介, 本郷邦広, 溝端知宏, 河田康志
- Organizer
  BMB2010 :第33回日本分子生物学会年会,第83回日本生化学会大会
- Place of Presentation
  神戸
- Year and Date
  2010-12-09
- Data Source
  KAKENHI-PROJECT-21570113
[Presentation] Altered Functional Characteristics of Circularly Permuted GroEL Variants2010
- Author(s)
  Tomohiro Mizobata
- Organizer
  The 3rd International Symposium on "Protein Community"
- Place of Presentation
  Hotel Nikko Nara, Nara Japan
- Year and Date
  2010-09-14
- Data Source
  KAKENHI-PROJECT-22570119
[Presentation] Isolation of short peptide segments from. lpha-synuclein fibril core identifies a residue important for fibril nucleation2010
- Author(s)
  Yasushi Kawata, Hisashi Yagi, Hideki Takeuchi, Kunihiro Hongo, Tomohiro Mizobata, and Yuji Goto
- Organizer
  The 24th Protein Society Meeting
- Place of Presentation
  San Diego
- Year and Date
  2010-08-04
- Data Source
  KAKENHI-PROJECT-21570113
[Presentation] コシャペロニンGroESのアミロイド線維形成と細胞毒性2009
- Author(s)
  吉田早穂, 岩佐尚徳, 本郷邦広, 溝端知宏, 河田康志
- Organizer
  第82回日本生化学会大会
- Place of Presentation
  神戸
- Year and Date
  2009-10-22
- Data Source
  KAKENHI-PROJECT-21570113
[Presentation] 古細菌Thermoplasma acidophilum由来単量体シャペロニンの金属特異的新規機能の解析2009
- Author(s)
  野井健太郎, 平井秀憲, 本郷邦広, 溝端知宏, 河田康志
- Organizer
  第50回日本生化学会中国四国支部例会
- Place of Presentation
  鳥取
- Year and Date
  2009-05-15
- Data Source
  KAKENHI-PROJECT-21570113
[Presentation] Gly192 at hinge 2 site in the chaperonin GroEL plays a pivotal role in the dynamic apical domain movement that leads to GroES binding and efficient encapsulation of substrate proteins2009
- Author(s)
  Yasushi Kawata, Kodai Machida, Ryoko Fujiwara, Tatsuhide Tanaka, Isao Sakane, Kunihiro Hongo, and Tomohiro Mizobata
- Organizer
  The 23rd Protein Society Meeting
- Place of Presentation
  Boston
- Year and Date
  2009-07-26
- Data Source
  KAKENHI-PROJECT-21570113
[Presentation] 変異解析・ストップフロー法を用いた大腸菌GroELの研究
- Author(s)
  水田敏史，植村達也，本郷邦広，河田康志，溝端知宏
- Organizer
  第14回日本蛋白質科学会年会
- Place of Presentation
  横浜
- Year and Date
  2014-06-25 – 2014-06-27
- Data Source
  KAKENHI-PROJECT-25440026
[Presentation] Using circular permutation to probe various characteristics of E. coli GroEL
- Author(s)
  Tomohiro Mizobata
- Organizer
  2012 Meeting on Molecular Chaperones and Stress Responses
- Place of Presentation
  Cold Spring Harbor Laboratory, New York
- Data Source
  KAKENHI-PROJECT-22570119
[Presentation] 大腸菌GroELの機能発現における頂上ドメインの動きと役割
- Author(s)
  溝端　知宏
- Organizer
  大阪大学蛋白質研究所セミナー「分子シャペロンの機能発現の新展開と細胞制御」
- Place of Presentation
  大阪大学蛋白質研究所
- Invited
- Data Source
  KAKENHI-PROJECT-22570119
[Presentation] クリスタリン蛋白質の凝集抑制に関わる内在性,外来性シャペロンの効果
- Author(s)
  下田香，山下智，本郷邦広，溝端知宏，小林沙織，河田康志
- Organizer
  第14回日本蛋白質科学会年会
- Place of Presentation
  横浜
- Year and Date
  2014-06-25 – 2014-06-27
- Data Source
  KAKENHI-PROJECT-25440026
[Presentation] Study of E. coli GroEL Using Stopped-Flow Analysis and Circular Permutation
- Author(s)
  Toshifumi Mizuta, Tatsuya Uemura, Kunihiro Hongo, Yasushi Kawata, Tomohiro Mizobata
- Organizer
  The 28th Annual Symposium of The Protein Society
- Place of Presentation
  San Diego CA USA
- Year and Date
  2014-07-27 – 2014-07-30
- Data Source
  KAKENHI-PROJECT-25440026
[Presentation] Elucidating the Molecular Mechanism of Chaperonin-facilitated Protein Folding
- Author(s)
  Tomohiro Mizobata
- Organizer
  2nd Seminar on Green Sustainable Chemistry in Tottori
- Place of Presentation
  鳥取大学
- Invited
- Data Source
  KAKENHI-PROJECT-22570119
[Presentation] パーキンソン病原因蛋白質α-synucleinのアミロイド線維に対するアントシアニンの効果
- Author(s)
  河田康志，平川和哉，本郷邦広，溝端知宏，小林沙織
- Organizer
  第14回日本蛋白質科学会年会
- Place of Presentation
  横浜
- Year and Date
  2014-06-25 – 2014-06-27
- Data Source
  KAKENHI-PROJECT-25440026
[Presentation] 家族性ALS発症原因タンパク質SOD1 G93A変異体のapo化による立体構造とアミロイド線維形成の特性変化
- Author(s)
  安藤瑞歩，井田昌孝，本郷邦広，溝端知宏，河田康志
- Organizer
  第14回日本蛋白質科学会年会
- Place of Presentation
  横浜
- Year and Date
  2014-06-25 – 2014-06-27
- Data Source
  KAKENHI-PROJECT-25440026
[Presentation] 円順列変異体GroELを用いたシャペロニンの機能解析
- Author(s)
  溝端知宏
- Organizer
  第１２回日本蛋白質科学会年会
- Place of Presentation
  名古屋国際会議場
- Invited
- Data Source
  KAKENHI-PROJECT-22570119
[Presentation] 蛍光Stopped-flow測定による変異体GroEL D398A-RWの動的解析
- Author(s)
  藤井豊，安藤華純，河田康志，溝端知宏
- Organizer
  第14回日本蛋白質科学会年会
- Place of Presentation
  横浜
- Year and Date
  2014-06-25 – 2014-06-27
- Data Source
  KAKENHI-PROJECT-25440026
[Presentation] Curious Characteristics of a Mutant Chaperonin GroEL with Multiple Cysteines in the Central Cavity
- Author(s)
  Tomohiro Mizobata, Shuhei Fusa, Masashi Ikeda, Kunihiro Hongo, Yasushi Kawata
- Organizer
  The 28th Annual Symposium of The Protein Society
- Place of Presentation
  San Diego, CA USA
- Year and Date
  2014-07-27 – 2014-07-30
- Data Source
  KAKENHI-PROJECT-25440026

1. KAWATA Yasushi (40177697)

# of Collaborated Projects: 13 results

# of Collaborated Products: 53 results
2. HONGO Kunihiro (80335504)

# of Collaborated Projects: 2 results

# of Collaborated Products: 9 results
3. 永井純 (50025334)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
4. 川畑伊知郎

# of Collaborated Projects: 0 results

# of Collaborated Products: 3 results
5. 福永浩司

# of Collaborated Projects: 0 results

# of Collaborated Products: 3 results
6. 渡邉保裕

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
7. 笹岡俊邦

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Mizobata Tomohiro 溝端 知宏

MIZOBATA Tomohiro 溝端 知宏

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E. coli HdeA: Analysis of the reversible formation of fibrils by an environmentally responsive molecular chaperonePrincipal Investigator

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Re-evaluation of the molecular mechanism of chaperonin action: characterization of circularly-permuted GroELPrincipal Investigator

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Functional and kinetic analysis of the inter-domain communication network of the chaperonin GroELPrincipal Investigator

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シャペロニンGroE存在下でのフォールディング反応条件を規定する分子機構の解明Principal Investigator

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変異型GroELを用いたシャペロニンの標的蛋白質結合メカニズムの解析Principal Investigator

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Mizobata Tomohiro 溝端知宏

MIZOBATA Tomohiro 溝端知宏