Oyamada Hideto 小山田英人

… Alternative Names

小山田英人オヤマダヒデト

OYAMADA Hideto 小山田英人

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Researcher Number	50266160
Other IDs
Affiliation (Current)	2025: 昭和医科大学, 医学部, 兼任講師
Affiliation (based on the past Project Information) *help	2025: 昭和医科大学, 医学部, 兼任講師 2020 – 2023: 昭和大学, 医学部, 兼任講師 2017 – 2019: 昭和大学, 医学部, 講師 2016: 昭和大学, 医学部, 助教 1997 – 2006: 昭和大学, 医学部, 助手 2000: 昭和大, 医学部, 助手
Review Section/Research Field	Principal Investigator General pharmacology / Basic Section 55050:Anesthesiology-related Except Principal Investigator Basic Section 55050:Anesthesiology-related / Applied pharmacology / General pharmacology / 応用薬理学・医療系薬学 / Neurochemistry/Neuropharmacology
Keywords	Principal Investigator カルシウムイオン / リアノジン受容体 / ryanodine receptor / calcium release channel / calcium ion / 悪性高熱症 / Tet On-Off / カルシウム放出チャンネル / 揮発性全身麻酔薬 / カルシウムシグナル … More / 遺伝子変異 / 1型リアノジン受容体 / dominant-negative / green fluorescent protein / CICR / 緑色蛍光蛋白質(GFP) / ドミナント・ネガティブ / 緑色蛍光蛋白質 / malignant hyperthermia / 分子生物学 … More Except Principal Investigator リアノジン受容体 / カルシウムイオン / 悪性高熱症 / 遺伝子変異体 / 遺伝子診断 / ryanodine receptor / calcium release channel / calcium ion / CICR / カルシウム放出チャンネル / 遺伝子発現 / Ca^<2+> / 緑色蛍光蛋白質 / malignant hyperthe / calcium　ion / cDNA cassette / cDNAカセット / malignant hyperthermia / 変異体 / RyR1 / 1型リアノジン受容体 / 薬理学 / 遺伝子 / 細胞内Ca2+イメージング / 培養細胞株 / リアノジン受容体1型 / 全身麻酔薬 / 疾患モデル / endoplasmic reticulum / green fluorescent protein(GFP) / 部分欠損クローン / 部分領域 / 小胞体 / 緑色蛍光蛋白質(GFP) / malignat hyperthermia / green fluorescent protein / rvanodine receptor / Green fluorescent protein (GFP) / PC12 cells / Regulation of expression / Intracellular translocation / Protein phosphorylation / calmodulin-dependent kinase II / Noradrenaline reuptake / Noradrenaline transporter / トランスロケーション / Green Fluorescent Protein (GFP) / PC12細胞 / 発現調節 / 細胞内移動 / 蛋白リン酸化 / カルモジュリン依存性キナーゼII / ノルアドレナリン再取り込み / ノルアドレナリントランスポーター Less

悪性高熱症の術前遺伝子診断に繋がる重要なRyR1変異体215種の機能解析Principal Investigator
- Principal Investigator
  
  小山田英人
- Project Period (FY)
  2025 – 2027
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 55050:Anesthesiology-related
- Research Institution
  Showa Medical University
悪性高熱症の遺伝子診断を目指した1型リアノジン受容体遺伝子変異体の作製と発現
- Principal Investigator
  
  小口勝司
- Project Period (FY)
  2019 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 55050:Anesthesiology-related
- Research Institution
  Showa University
A trial for establishment of the cell banks as the models of malignant hyperthemia
- Principal Investigator
  
  Oguchi Katsuji
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Applied pharmacology
- Research Institution
  Showa University
SCREENING FOR THE FUNCTIONAL DOMAINS IN THE RYANODINE RECEPTOR
- Principal Investigator
  
  OGUCHI Katsuji
- Project Period (FY)
  2003 – 2006
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  General pharmacology
- Research Institution
  SHOWA UNIVERSITY
DEVELOPMENT OF THE VISUALIZED DOMINANT NEGATIVE METHOD FOR THE CALCIUM RELEASE CHANNELPrincipal Investigator
- Principal Investigator
  
  OYAMADA Hideto
- Project Period (FY)
  2002 – 2003
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  General pharmacology
- Research Institution
  SHOWA UNIVERSITY
SPATIO-TEMPORAL ANALYSIS OF CA^<2+> RELEASE CHANNEL RELATED TO THE VARIOUS TYPE OF THE INTRACELLULAR CA^<2+> SIGNALS
- Principal Investigator
  
  OGUCHI Katsuji
- Project Period (FY)
  2000 – 2002
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  応用薬理学・医療系薬学
- Research Institution
  SHOWA UNIVERSITY
THE CONTROL OF CA2+ RELEASE CHANNEL EXPRESSION BY THE TET ON-OFF SYSTEMS.Principal Investigator
- Principal Investigator
  
  OYAMADA Hideto
- Project Period (FY)
  1999 – 2000
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  General pharmacology
- Research Institution
  SHOWA UNIVERSITY
Regulation of function and protein expression of noradrenaline transporter by protein kinases
- Principal Investigator
  
  KIUCHI Yuji
- Project Period (FY)
  1999 – 2000
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Neurochemistry/Neuropharmacology
- Research Institution
  Showa University
生きた細胞におけるカルシウム放出チャンネル蛋白質の可視化
- Principal Investigator
  
  OGUCHI Katsuji
- Project Period (FY)
  1998
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas (A)
- Research Institution
  Showa University
cDNAカセットを用いた変異体作製法によるリアノジン受容体の機能領域の検索Principal Investigator
- Principal Investigator
  
  小山田英人
- Project Period (FY)
  1997 – 1998
- Research Category
  
  Grant-in-Aid for Encouragement of Young Scientists (A)
- Research Field
  
  General pharmacology
- Research Institution
  Showa University

All 2022 2020 2019 2018 2017 2006

All Journal Article Presentation Book

[Book] 悪性高熱症 for professional anesthesiologist(菊地博達編)2006
- Author(s)
  小山田英人
- Total Pages
  204
- Publisher
  克誠堂出版
- Data Source
  KAKENHI-PROJECT-15590234
[Book] 悪性高熱症for professional anesthesiologist(菊地博達編)2006
- Author(s)
  小山田英人
- Total Pages
  204
- Publisher
  克誠堂出版
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15590234
[Journal Article] Heat-hypersensitive mutants of ryanodine receptor type 1 revealed by microscopic heating2022
- Author(s)
  Oyama Kotaro、Zeeb Vadim、Yamazawa Toshiko、Kurebayashi Nagomi、Kobirumaki-Shimozawa Fuyu、Murayama Takashi、Oyamada Hideto、Noguchi Satoru、Inoue Takayoshi、Inoue Yukiko U.、Nishino Ichizo、Harada Yoshie、Fukuda Norio、Ishiwata Shin’ichi、Suzuki Madoka
- Journal Title
  
  Proceedings of the National Academy of Sciences
  
  Volume: 119 Issue: 32
- DOI
  10.1073/pnas.2201286119
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K09383, KAKENHI-PROJECT-21K06789, KAKENHI-PROJECT-22K06652, KAKENHI-PROJECT-21K19929, KAKENHI-PLANNED-20H05785, KAKENHI-PLANNED-22H05053, KAKENHI-PLANNED-22H05054, KAKENHI-PLANNED-22H05055, KAKENHI-PROJECT-20H03421, KAKENHI-PROJECT-19K07105, KAKENHI-PROJECT-19K07306, KAKENHI-PROJECT-20K06467, KAKENHI-PROJECT-19H03404, KAKENHI-PROJECT-23K23847, KAKENHI-PROJECT-23K24778, KAKENHI-PROJECT-23K24067
[Journal Article] Insights into channel modulation mechanism of RYR1 mutants using Ca2+ imaging and molecular dynamics2020
- Author(s)
  Yamazawa Toshiko、Ogawa Haruo、Murayama Takashi、Yamaguchi Maki、Oyamada Hideto、Suzuki Junji、Kurebayashi Nagomi、Kanemaru Kazunori、Oguchi Katsuji、Sakurai Takashi、Iino Masamitsu
- Journal Title
  
  The Journal of General Physiology
  
  Volume: 152 Issue: 1 Pages: 0-0
- DOI
  10.1085/jgp.201812235
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K07105, KAKENHI-PROJECT-19K07306, KAKENHI-PROJECT-19K09383, KAKENHI-PROJECT-16H04667, KAKENHI-PROJECT-16K08507, KAKENHI-PROJECT-19H03198, KAKENHI-PROJECT-19H03404
[Journal Article] Construction of an all-in-one double-conditional shRNA expression vector2019
- Author(s)
  Kudo Y, Oyamada H, Matsuoka T, Inagaki A, Tsuchiya H, Ao Y, Kimura AM, Tsuji M, Oguchi K, Kiuchi Y.
- Journal Title
  
  Showa Univ J Med Sci
  
  Volume: 31 Pages: 41-50
- NAID
  130007662338
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16K08917
[Journal Article] Efficient high-throughput screening by endoplasmic reticulum Ca2+ measurement to identify inhibitors of ryanodine receptor Ca2+-release channels.2018
- Author(s)
  Murayama T, Kurebayashi N, Ishigami-Yuasa M, Mori S, Suzuki Y, Akima R, Ogawa H, Suzuki J, Kanemaru K, Oyamada H, Kiuchi Y, Iino M, Kagechika H, Sakurai T.
- Journal Title
  
  Mol Pharmacol.
  
  Volume: 94 Pages: 722-730
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16K08917
[Journal Article] MALIGNANT HYPERTHERMIA for Professional Anesthesiologists (ed by Hirosatsu Kikuchi, MD and Ph.D)2006
- Author(s)
  Hideto Oyamada
- Journal Title
  
  Kokuseido Co LTD
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15590234
[Presentation] Fast and easy construction method of ryanodine receptor mutants aiming at genetic screening of malignant hyperthermia diagnosis2020
- Author(s)
  Oyamada H, Nakano M, Hayashi T, Ubukata Y, Makino T, Tanaka M, Kikuchi T, Oguchi K, Kiuchi Y.
- Organizer
  第92回日本薬理学会年会
- Data Source
  KAKENHI-PROJECT-19K09383
[Presentation] Design and constructs of the single “All-in-One”type single double-conditional shRNA expression vectors for a spatio-temporal gene and/or cell targeting2019
- Author(s)
  Oyamada H, Ao Y, Kudo Y, Okamoto R, Matsuoka T, Inagaki A, Aoyama E, Oguchi K, Kiuchi Y.
- Organizer
  第92回日本薬理学会年会
- Data Source
  KAKENHI-PROJECT-16K08917
[Presentation] Construction and integration of the All-in-One type single double-conditional shRNA expression vectors for spatio-temporal gene and/or cell targeting.2019
- Author(s)
  Oyamada H, Ao Y, Kudo Y, Matsuoka T, Okamoto R, Murayama T, Yamazawa T, Kakizawa S, Oguchi T, Kimura MA, Yasumoto T, Mori Y, Tsuji M, Oguchi K, Kiuchi Y.
- Organizer
  第42回日本神経科学大会( 共同開催：第62回日本神経化学会大会)
- Data Source
  KAKENHI-PROJECT-19K09383
[Presentation] 悪性高熱症関連変異を有する骨格筋型リアノジン受容体の構造と機能変化2018
- Author(s)
  山澤徳志子，山口眞紀，小川治夫，村山尚，小山田英人，呉林なごみ，鈴木純二，金丸和典，櫻井隆，飯野正光
- Organizer
  日本筋学会第4回学術集会
- Data Source
  KAKENHI-PROJECT-16K08917
[Presentation] 小胞体内Ca2+濃度測定を利用した新規RyR1阻害薬のハイスループットスクリーニング2018
- Author(s)
  村山尚，呉林なごみ，湯浅磨里[石上] ，森修一，鈴木志奈，秋間龍之介，小川治夫，鈴木純二，金丸和典，小山田英人，木内祐二，飯野正光，影近弘之，櫻井隆
- Organizer
  日本筋学会第4回学術集会
- Data Source
  KAKENHI-PROJECT-16K08917
[Presentation] Correlation of molecular dynamics analysis and Calcium dynamics in mutant type 1 ryanodine receptors2017
- Author(s)
  山澤德志子, 村山尚, 山口眞紀, 小山田英人, 呉林なごみ, 鈴木純二, 金丸和典, 櫻井隆, 飯野正光
- Organizer
  第55回　日本生物物理学会年会
- Data Source
  KAKENHI-PROJECT-16K08917
[Presentation] A novel screeniing method for drugs inhibiting type 1 ryanodine receptor （RyR1) by ER Ca2+ monitoring2017
- Author(s)
  鈴木志奈、秋間龍之介、村山尚、呉林なごみ、湯浅麻里、森修一、影近弘之、鈴木純二、金丸和典、飯野正光、小山田英人、小口勝司、小川治夫、豊島近、櫻井隆
- Organizer
  第90回日本薬理学会年会
- Place of Presentation
  長崎ブリックホール
- Year and Date
  2017-03-15
- Data Source
  KAKENHI-PROJECT-16K08917
[Presentation] Genotype-phenotype correlations of central core disease mutaitions in the C-terminal region fo the RYR1 channel2017
- Author(s)
  村山尚、呉林なごみ、小川治夫、山澤徳志子、小山田英人、小口勝司、櫻井隆
- Organizer
  第90回日本薬理学会年会
- Place of Presentation
  長崎ブリックホール
- Year and Date
  2017-03-15
- Data Source
  KAKENHI-PROJECT-16K08917

1. OGUCHI Katsuji (50129821)

# of Collaborated Projects: 6 results

# of Collaborated Products: 7 results
2. KIUCHI Yuji (50204821)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
3. 山澤徳志子 (00282616)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
4. 村山尚 (10230012)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
5. 金丸和典 (10456105)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. 柿澤昌 (40291059)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. 鈴木団 (40350475)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. 国広なごみ

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Oyamada Hideto 小山田 英人

小山田 英人 オヤマダ ヒデト

OYAMADA Hideto 小山田 英人

Research Projects

Research Products

Co-Researchers

悪性高熱症の術前遺伝子診断に繋がる重要なRyR1変異体215種の機能解析Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

悪性高熱症の遺伝子診断を目指した1型リアノジン受容体遺伝子変異体の作製と発現

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

A trial for establishment of the cell banks as the models of malignant hyperthemia

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

SCREENING FOR THE FUNCTIONAL DOMAINS IN THE RYANODINE RECEPTOR

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

DEVELOPMENT OF THE VISUALIZED DOMINANT NEGATIVE METHOD FOR THE CALCIUM RELEASE CHANNELPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

SPATIO-TEMPORAL ANALYSIS OF CA^<2+> RELEASE CHANNEL RELATED TO THE VARIOUS TYPE OF THE INTRACELLULAR CA^<2+> SIGNALS

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

THE CONTROL OF CA2+ RELEASE CHANNEL EXPRESSION BY THE TET ON-OFF SYSTEMS.Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Regulation of function and protein expression of noradrenaline transporter by protein kinases

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

生きた細胞におけるカルシウム放出チャンネル蛋白質の可視化

Principal Investigator

Project Period (FY)

Research Category

Research Institution

cDNAカセットを用いた変異体作製法によるリアノジン受容体の機能領域の検索Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Book] 悪性高熱症 for professional anesthesiologist(菊地博達 編)2006

Author(s)

Total Pages

Publisher

Data Source

[Book] 悪性高熱症for professional anesthesiologist(菊地博達 編)2006

Author(s)

Total Pages

Publisher

Description

Data Source

[Journal Article] Heat-hypersensitive mutants of ryanodine receptor type 1 revealed by microscopic heating2022

Author(s)

Journal Title

DOI

Oyamada Hideto 小山田英人

小山田英人オヤマダヒデト

OYAMADA Hideto 小山田英人

[Book] 悪性高熱症 for professional anesthesiologist(菊地博達編)2006

[Book] 悪性高熱症for professional anesthesiologist(菊地博達編)2006