KOIKE Tatsuya 小池達也

Researcher Number	50271177
Other IDs
Affiliation (based on the past Project Information) *help	2013: 大阪市立大学, 医学(系)研究科(研究院), 教授 2011 – 2012: 大阪市立大学, 医学(系)研究科(研究院), 准教授 2007 – 2009: Osaka City University, 大学院・医学研究科, 准教授 2002 – 2006: 大阪市立大学, 大学院・医学研究科, 助教授 2004: 大阪市立大学, 大学院医学研究科, 助教授
Review Section/Research Field	Principal Investigator Orthopaedic surgery Except Principal Investigator Orthopaedic surgery / Biological Sciences
Keywords	Principal Investigator cAMP / negative feed back / Smad6 / レプチン / 関節炎 / 肥満 / 骨形成因子 / phosphorylation / pentoxifyline / pharmacological transmission … More / bone morphogenetic protein / osteogenesis / smad / 骨形成タンパク(BMP) / リン酸化 / ペントキシフィリン / 薬物伝達系 / 骨形成蛋白(BMP) / 骨形成 / トランスジェニック / マウス / 炎症 / 誘発性関節炎 / レプチン抵抗性 / 関節リウマチ / PTH / CREB / シグナル伝達 / BMP / 骨芽細胞様細胞 / サイクリックAMP / 細胞内情報伝達系 / 副甲状腺ホルモン … More Except Principal Investigator CRPS-1 / sensory nerve / rheumatoid arthritis / bone metabolism / Brown-Sequard syndrome / adjuvant induced arthritis / 脊髄損傷(Brown-Sequard syndrome) / 知覚神経 / 関節リウマチ / 骨代謝 / 脊髄損傷(Brown-Sequard症候群) / アジュバント関節炎 / TNF-α / PDE阻害剤 / BMP(骨形成因子) / PDE(Phosphodiesterase) / 生体分岐ポリマー / 薬物伝達系 / 人工骨 / 骨再生 / 骨形成 / 生体材料 / DDS / 再生医療 / 骨形成タンパク / 骨修復 Less

Effect of lipid cytokine on arthritisPrincipal Investigator
- Principal Investigator
  
  KOIKE Tatsuya
- Project Period (FY)
  2011 – 2013
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Orthopaedic surgery
- Research Institution
  Osaka City University
コラーゲン誘発関節炎の発症進展へのレプチン抵抗性の関与Principal Investigator
- Principal Investigator
  
  小池達也
- Project Period (FY)
  2008 – 2009
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Orthopaedic surgery
- Research Institution
  Osaka City University
Crosstalk of intra-cellular signaling pathway in bone formationPrincipal Investigator
- Principal Investigator
  
  KOIKE Tatsuya
- Project Period (FY)
  2006 – 2008
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Orthopaedic surgery
- Research Institution
  Osaka City University
Regulation of intracellular signal transmission for osteogenesisPrincipal Investigator
- Principal Investigator
  
  KOIKE Tatsuya
- Project Period (FY)
  2003 – 2005
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Orthopaedic surgery
- Research Institution
  Osaka City University
The role of sensory nerve in destruction of bone and joint in rheumatoid arthritis
- Principal Investigator
  
  EGI Takeshi, 乾健太郎
- Project Period (FY)
  2002 – 2004
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Orthopaedic surgery
- Research Institution
  Osaka City University
骨形成促進制御の技術開発-ホスホジエステラーゼ群の骨形成機序での役割の解明-
- Principal Investigator
  
  TAKAOKA Kunio
- Project Period (FY)
  2000 – 2004
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Osaka City University
  Shinshu University

All 2014 2013 2012 2011 2009 2008 2007 2006 2005 2004 Other

All Journal Article Presentation Book

[Book] New Frontiers in Regenerative Medicine(M. Kusano and S. Shioda Eds.)(Springer)2007
- Author(s)
  B.Zhao, T.Katagiri, H.Toyoda, T.Takada, T.Koike, K.Takaoka, R.Kamijo
- Publisher
  Heparin enhances BMP activity by maintaining high levels of nuclear phophorylated Smad1/5/8
- Data Source
  KAKENHI-PROJECT-18390421
[Book] Heparin enhances BMP activity by maintaining high levels of nuclear phosphorylated Smad1/5/82006
- Author(s)
  Zhao B, Katagiri T, Toyoda H, Takada T, Koike T, Takaoka K, and Kamijo R. eds. Kusano M and Shioda S Springer, Japan
- Publisher
  Frontiers in Regenerative Medicine
- Data Source
  KAKENHI-PROJECT-18390421
[Journal Article] Nucleated cells circulating in the peripheral blood contribute to the repair of osteochondral defects only in the early phase of healing2013
- Author(s)
  Okano T., Wakitani S., Okabe T., Takahashi M., Koike T., Nakamura H.
- Journal Title
  
  J Tissue Eng Regen Med
  
  Volume: in press Issue: 5 Pages: 414-420
- DOI
  10.1002/term.1536
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23592226
[Journal Article] Risk factors for severe nonsteroidal anti-inflammatory drug-induced small intestinal damage2013
- Author(s)
  T. Watanabe, T. Tanigawa, Y. Nadatani, Y. Nagami, S. Sugimori, H. Okazaki, H. Yamagami, K. Watanabe, K. Tominaga, Y. Fujiwara, T. Koike, T. Arakawa
- Journal Title
  
  Digest Liver Dis
  
  Volume: in press Issue: 5 Pages: 390-395
- DOI
  10.1016/j.dld.2012.12.005
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23592226
[Journal Article] Acquired leptin resistance by high-fat feeding reduces inflammation from collagen antibody-induced arthritis in mice.2012
- Author(s)
  Sugioka Y., Okano T., Tada M., Nakamura H., Koike T.
- Journal Title
  
  Clinical and Experimental Rheumatology.
  
  Volume: in press
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23592226
[Journal Article] Comparison of joint destruction between standard- and low-dose etanercept in rheumatoid arthritis from the Prevention of Cartilage Destruction by Etanercept (PRECEPT) study2012
- Author(s)
  Masahiro Tada, Tatsuya Koike, Tadashi Okano, Yuko Sugioka, Shigeyuki Wakitani, Kenzo Fukushima, Akira Sakawa, Kazunori Uehara, Kentaro Inui and Hiroaki Nakamura
- Journal Title
  
  Rheumatology
  
  Volume: 51 Pages: 2164-9
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23592226
[Journal Article] Acquired leptin resistance by high-fat feeding reduces inflammation from collagen antibody-induced arthritis in mice2012
- Author(s)
  Sugioka Y, Okano T, Tada M, Nakamura H, Koike T
- Journal Title
  
  Clin Exp Rheumatol
  
  Volume: 30 Pages: 707-707
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23592226
[Journal Article] Efficacy of infliximab therapy for a patient with superficial thrombophlebitis and rheumatoid arthritis.2011
- Author(s)
  Tada M., Fukai K., Okano T., Sugioka Y., Wakitani S., Nakamura H., Koike T.
- Journal Title
  
  International Journal of Clinical Medicine
  
  Volume: 2 Pages: 459-462
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23592226
[Journal Article] Parathyroid hormone enhances bone morphogenetic protein activity by increasing intracellular 3'2009
- Author(s)
  Nakao Y, Koike T, Ohta Y, Manaka T, Imai Y, Takaoka K
- Journal Title
  
  5'-cyclic adenosine monophosphate accumulation in osteoblastic MC3T3-E1 cell Bone 44
  
  Pages: 872-877
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18390421
[Journal Article] Cyclic AMP enhances Smad-mediated BMP signaling through PKA-CREB pathway2008
- Author(s)
  Ohta Y, Nakagawa K, ImaiY, Katagiri T, Koike T, Takaoka K
- Journal Title
  
  J Bone Miner Metab 26(5)
  
  Pages: 478-484
- NAID
  10024459494
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18390421
[Journal Article] Wnt/b-catenin signaling in chondrocyte function and cartilage matrix disruption2006
- Author(s)
  Enomoto-Iwamoto M., Otani T., Koike T., Iwamoto M.
- Journal Title
  
  Current Rheumatology Reviews 2
  
  Pages: 31-38
- Data Source
  KAKENHI-PROJECT-18390421
[Journal Article] Heparin potentiates the in vivo ectopic bone formation induced by bone morphogenetic protein-22006
- Author(s)
  B.Zhao, T.Katagiri, H.Toyod, T.Takada, T.Yanai, T.Fukuda, U.Chang, T.Koike, K.Takaoka, R.Kamijo
- Journal Title
  
  J Biol Chem 281
  
  Pages: 23246-23253
- Data Source
  KAKENHI-PROJECT-18390421
[Journal Article] Bone morphogenetic protein activities are enhanced by 3',5'-cyclic adenosine monophosphate through suppression of Smad6 expression in osteoprogenitor cells2006
- Author(s)
  Sugama R, Koike T., Imai Y, Nomura-Furukawa C., Takaoka K.
- Journal Title
  
  Bone 38
  
  Pages: 206-214
- Data Source
  KAKENHI-PROJECT-18390421
[Journal Article] Heparin potentiates the in vivo ectopic bone formation induced by bone morphogenetic protein-22006
- Author(s)
  Zhao B, Katagiri T, Toyoda H, Takada T, Yanai T, Fukuda T, Chung U-I, Koike T, Takaoka K, and Kamijo R.
- Journal Title
  
  J Biol Chem 281
  
  Pages: 23246-23253
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18390421
[Journal Article] Use of local electroporation enhances methotrexate effects with minimum dose in adjuvant-induced arthritis.2005
- Author(s)
  M.Tada, K.Inui, T.Koike, K.Takaoka
- Journal Title
  
  Arthritis Rheum In press
- Data Source
  KAKENHI-PROJECT-14571396
[Journal Article] Open reduction of the dislocated hip in juvenile idiopathic arthritis : a case report.2004
- Author(s)
  K.Inui, T.Maeno, M.Tada, K.Takaoka, T.Koike
- Journal Title
  
  Modern Rheumatol 14
  
  Pages: 399-401
- NAID
  10020420223
- Data Source
  KAKENHI-PROJECT-14571396
[Presentation] VERY-HIGH-CONCENTRATION LEPTIN SUPPRESSES AGGRAVATION OF COLLAGEN ANTIBODY-INDUCED ARTHRITIS IN MICE2014
- Author(s)
  Tadashi Okano, Tatsuya Koike, Yuko Sugioka, Masahiro Tada, Kenji Mamoto, Kentaro Inui, Hiroyuki Okihana, Ken Ebihara, Kazuwa Nakao, Hiroaki Nakamura
- Organizer
  Annual European Congress of Rheumatology EULAR 2014
- Place of Presentation
  Le Palais des Congress de Paris, Paris, France
- Data Source
  KAKENHI-PROJECT-23592226
[Presentation] Hyoerleptinemia suppresses aggravation of arthritis of collagen antibody-induced arthritis in mice2014
- Author(s)
  Okano T, Koike T, Inui K, Tada M, Sugioka Y, Mamoto K, Nakamura H
- Organizer
  Eular 2014
- Place of Presentation
  Paris (採択)
- Year and Date
  2014-06-13
- Data Source
  KAKENHI-PROJECT-23592226
[Presentation] 高用量レプチンによって関節炎の重症化は抑制される2012
- Author(s)
  岡野匡志、小池達也、多田昌弘、杉岡優子、沖花裕行、中村博亮
- Organizer
  第27回日本整形外科学会基礎学術総会
- Place of Presentation
  名古屋
- Year and Date
  2012-10-27
- Data Source
  KAKENHI-PROJECT-23592226
[Presentation] Adipocytokines affect the bone metabolism of rheumatoid arthritis patients - TOMORROW study -2011
- Author(s)
  Sugioka Y., Okano T., Tada M., Koike T.
- Organizer
  The 33rd Annual Meeting of American Society for Bone and Mineral Research
- Place of Presentation
  San Diego, Californis, USA
- Data Source
  KAKENHI-PROJECT-23592226
[Presentation] Impact of adipocytokines on disease activity in rheumatoid arthritis patients - TOMORROW study-2011
- Author(s)
  Sugioka Y., Wakitani S., Mamoto K., Okano T., Tada M., Nakamura H., Koike T.
- Organizer
  2011 Annual European Congress of Rheumatology
- Place of Presentation
  London, United Kingdom
- Data Source
  KAKENHI-PROJECT-23592226
[Presentation] 関節リウマチ患者においてレプチンの骨代謝、炎症に与える影響について2011
- Author(s)
  杉岡優子、脇谷滋之、真本建司、岡野匡志、多田昌弘、神山敦子、中村博亮、小池達也
- Organizer
  第84回日本整形外科学会学術集会
- Place of Presentation
  福岡
- Year and Date
  2011-05-12
- Data Source
  KAKENHI-PROJECT-23592226
[Presentation] Parathyroid hormone enhances bone morphogenetic protein activity by increasing intracellular 3' 5'-cyclic adenosine monophosphate accumulation in osteoblastic MC3T3-E1 cell2009
- Author(s)
  Nakao Y, Koike T, Ohta Y, Manaka T, Imai Y, Takaoka K.
- Organizer
  第55回アメリカ整形外科基礎学会、ラスベガス
- Year and Date
  2009-02-22
- Data Source
  KAKENHI-PROJECT-18390421
[Presentation] Endogenous Cyclic Adenosine 3', 5'-Monophosphate AMP Response Element-Binding Protein (CREB) Signaling Enhances Smad-Mediated Bone Morphogenetic Protein (BMP) Signaling. Journal of Bone and Mineral Research 22 : S3912007
- Author(s)
  Ohta Y, Nakagawa K, Imai Y, Katagiri T, Koike T, Takaoka K
- Organizer
  第29回アメリカ骨ミネラル代謝学会
- Place of Presentation
  ホノルル
- Year and Date
  2007-09-19
- Data Source
  KAKENHI-PROJECT-18390421
[Presentation] Cyclic AMP Accelerates BMP Signaling by Enhancing the Transcriptional Activity of BMP Responsive Element through Cyclic AMP Responsive Element. Journal of Bone and Mineral Research 21 : S1262006
- Author(s)
  Ohta Y, Nakagawa K, Imai Y, Nomura C, Katagiri T, Koike T, Takaoka K
- Organizer
  第28回アメリカ骨ミネラル代謝学会
- Place of Presentation
  フィラデルフィア
- Year and Date
  2006-09-16
- Data Source
  KAKENHI-PROJECT-18390421
[Presentation] Enhancement of BMP signaling by cyclic AMP : Its role and mechanism. Bone 38 : S172006
- Author(s)
  Ohta Y, Nakagawa K, Imai Y, Nomura C, Katagiri T, Koike T, Takaoka K
- Organizer
  ダボス骨ワークショップ
- Place of Presentation
  ダボス
- Year and Date
  2006-03-18
- Data Source
  KAKENHI-PROJECT-18390421
[Presentation] Impact of disease activity on lipid profiles and adipocytokines in patients with rheumatoid arthritis -The TOMORROW study-
- Author(s)
  Sugioka Y, Koike T, Mamoto K, Okano T, Tada M, Wakitani S, Nakamura H
- Organizer
  EULAR 2012
- Place of Presentation
  Messe Berlin, Berlin, Germany
- Data Source
  KAKENHI-PROJECT-23592226
[Presentation] Power Doppler signal Is frequently positive among patients with rheumatoid arthritis in clinical remission and normal serum matrix metalloproteinase-3 (MMP-3) levels
- Author(s)
  Tadashi Okano, Tatsuya Koike, Masahiro Tada, Kenji Mamoto, Yuko Sugioka, Atsuko Kamiyama and Hiroaki Nakamura
- Organizer
  76th American Collage of Rheumatology
- Place of Presentation
  Walter E. Washington Convention Center, Washington DC, USA
- Data Source
  KAKENHI-PROJECT-23592226

1. TAKAOKA Kunio (30112048)

# of Collaborated Projects: 3 results

# of Collaborated Products: 11 results
2. KATAGIRI Takenobu (80245802)

# of Collaborated Projects: 3 results

# of Collaborated Products: 8 results
3. ITO Yoichi (00326266)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
4. 乾健太郎 (00291592)

# of Collaborated Projects: 2 results

# of Collaborated Products: 2 results
5. WAKITANI Shigeyuki (70243243)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. EBIHARA Ken (70362514)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
7. TADA Masahiro (20514235)

# of Collaborated Projects: 1 results

# of Collaborated Products: 12 results
8. EGI Takeshi (00336778)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. 斎藤直人 (80283258)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. 北野利夫 (50291597)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. 木下哲也 (30313860)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
12. 江原宗平 (40176780)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results

KOIKE Tatsuya 小池 達也

Research Projects

Research Products

Co-Researchers

Effect of lipid cytokine on arthritisPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

コラーゲン誘発関節炎の発症進展へのレプチン抵抗性の関与Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Crosstalk of intra-cellular signaling pathway in bone formationPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Regulation of intracellular signal transmission for osteogenesisPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

The role of sensory nerve in destruction of bone and joint in rheumatoid arthritis

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

骨形成促進制御の技術開発-ホスホジエステラーゼ群の骨形成機序での役割の解明-

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

[Book] New Frontiers in Regenerative Medicine(M. Kusano and S. Shioda Eds.)(Springer)2007

Author(s)

Publisher

Data Source

[Book] Heparin enhances BMP activity by maintaining high levels of nuclear phosphorylated Smad1/5/82006

Author(s)

Publisher

Data Source

[Journal Article] Nucleated cells circulating in the peripheral blood contribute to the repair of osteochondral defects only in the early phase of healing2013

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Risk factors for severe nonsteroidal anti-inflammatory drug-induced small intestinal damage2013

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Acquired leptin resistance by high-fat feeding reduces inflammation from collagen antibody-induced arthritis in mice.2012

Author(s)

Journal Title

Data Source

[Journal Article] Comparison of joint destruction between standard- and low-dose etanercept in rheumatoid arthritis from the Prevention of Cartilage Destruction by Etanercept (PRECEPT) study2012

Author(s)

Journal Title

Data Source

[Journal Article] Acquired leptin resistance by high-fat feeding reduces inflammation from collagen antibody-induced arthritis in mice2012

Author(s)

Journal Title

Data Source

[Journal Article] Efficacy of infliximab therapy for a patient with superficial thrombophlebitis and rheumatoid arthritis.2011

Author(s)

Journal Title

Data Source

[Journal Article] Parathyroid hormone enhances bone morphogenetic protein activity by increasing intracellular 3'2009

Author(s)

Journal Title

Data Source

[Journal Article] Cyclic AMP enhances Smad-mediated BMP signaling through PKA-CREB pathway2008

Author(s)

KOIKE Tatsuya 小池達也