HIRATA Youko 平田洋子

… Alternative Names

平田洋子ヒラタヨウコ

HIRATA Yoko 平田洋子

Less

Researcher Number	50271523
Other IDs
Affiliation (Current)	2025: 岐阜大学, 高等研究院, 特任教授
Affiliation (based on the past Project Information) *help	2023: 岐阜大学, 高等研究院, 特任教授 2019 – 2022: 岐阜大学, 工学部, 教授 2009 – 2011: Gifu University, 工学部, 准教授 2007: Gifu University, Factclty of Engineering, Associate Professor 2004 – 2006: 岐阜大学, 工学部, 助教授 1996 – 1997: 理化学研究所, 運動遺伝子研究チーム, フロンティア研究員
Review Section/Research Field	Principal Investigator Neurochemistry/Neuropharmacology / Basic Section 59040:Nutrition science and health science-related / Neurochemistry/Neuropharmacology Except Principal Investigator Basic Section 33020:Synthetic organic chemistry-related / Living organism molecular science
Keywords	Principal Investigator Nurr1 / NGFI-B(Nur77) / 蛍光プローブ / オキシトーシス / 鉄イオン / 酸化ストレス / フェロトーシス / prostaglandin / caspase-3 / Parkinson's disease … More / manganese / rotenone / apoptosis / 活性酸素種 / ドーパミン / 神経保護物質 / ドーバミン神経 / プロスタグランディン / カスパーゼ-3 / パーキンソン病 / マンガン / ロテノン / アポトーシス / Rat brain / Protein Kinase Cbeta / Limited proteolysis / Calpain / Protein kinase C beta / NGFI-B kinase / ラット脳 / プロテインキナーゼCβ / 限定分解 / カルパイン / シクロペンテノン / 脳虚血 / シクロペンテノン誘導体 / MAPキナーゼ / C6グリオーマ細胞 / 神経成長因子 / 脳由来神経栄養因子 / グリア細胞株由来神経栄養因子 … More Except Principal Investigator リン原子キラリティ / ビナフチルチオホスホン酸エステル / 計算化学 / リン原子キラリティー / 円偏光発光 / 反応経路理論解析 / 小胞体ストレス / リン原子上置換反応 / キラリティー転写 / ビナフチル基 / P-キラルホスフィン酸エステル / キラリティー転写反応 / 中心性キラリティー / 軸性キラリティー / P-キラル有機リン化合物 / Molecular Probe / Keapl / Prostaglandin / Apoptosis / Parkinson's disease / Cyclopentenone / Neuroprotective / NEPP / スルファニル置換体 / 抗アポトーシス / 分子プローブ / Keap1 / プロスタグランジン / アポトーシス / パーキンソン病 / シクロペンテノン / 神経保護 Less

Development of feroptosis inhibitors based on the novel antioxidative mechanismPrincipal Investigator
- Principal Investigator
  
  平田洋子
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 59040:Nutrition science and health science-related
- Research Institution
  Gifu University
Development of syntehtic reactions based on the tetracoorinate phosphorus compounds with a chrality
- Principal Investigator
  
  Murai Toshiaki
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 33020:Synthetic organic chemistry-related
- Research Institution
  Gifu University
Up-regulation of glial cell line-derived neurotrophic factor by newly synthesized cyclopentenone derivatives : Studies on cellular mechanisms in vitro and effectiveness in vivoPrincipal Investigator
- Principal Investigator
  
  HIRATA Yoko
- Project Period (FY)
  2009 – 2011
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Neurochemistry/Neuropharmacology
- Research Institution
  Gifu University
Synthesis and Application of Novel Cyclopentenone Molecular Probes with Neuroprotective Activity
- Principal Investigator
  
  FURUTA Kyoji
- Project Period (FY)
  2005 – 2007
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Living organism molecular science
- Research Institution
  Gifu University
Studies of molecular mechanisms of rotenone-induced apoptosis and neurotrophic substances for dopaminergic neuronsPrincipal Investigator
- Principal Investigator
  
  HIRATA Yoko
- Project Period (FY)
  2004 – 2005
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Neurochemistry/Neuropharmacology
- Research Institution
  Gifu University
Studies for the phosphorylation and signaling pathway of a transcription factor induced by neuronal defferentiationPrincipal Investigator
- Principal Investigator
  
  HIRATA Yoko
- Project Period (FY)
  1996 – 1997
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Neurochemistry/Neuropharmacology
- Research Institution
  The Institute of Physical and Chemical Research (RIKEN)

All 2023 2022 2020 2011 2010 2009 2007 2006 2005

All Journal Article Presentation

[Journal Article] Structural features localizing the ferroptosis inhibitor GIF-2197-r to lysosomes2023
- Author(s)
  Hirata Y, Hashimoto T, Ando K, Kamatari YO, Takemori H, Furuta K
- Journal Title
  
  RSC Adv
  
  Volume: 13 Issue: 46 Pages: 32276-32281
- DOI
  10.1039/d3ra06611h
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K11824, KAKENHI-PROJECT-23K28190
[Journal Article] Antiferroptotic Activities of Oxindole GIF-0726-r Derivatives: Involvement of Ferrous Iron Coordination and Free-Radical Scavenging Capacities2023
- Author(s)
  Takahashi M, Hamamoto A, Oh-Hashi K, Takemori H, Furuta K, Hirata Y.
- Journal Title
  
  ACS Chem Neurosci.
  
  Volume: － Issue: 10 Pages: 1826-1833
- DOI
  10.1021/acschemneuro.3c00042
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21K17638, KAKENHI-PROJECT-22K11824, KAKENHI-PROJECT-23K04504
[Journal Article] Quercetin and resveratrol inhibit ferroptosis independently of Nrf2-ARE activation in mouse hippocampal HT22 cells,2023
- Author(s)
  Kato K, Takahashi M, Oh-hashi K, Ando K, Hirata Y
- Journal Title
  
  Food Chem Toxicol
  
  Volume: 172 Pages: 113586-113586
- DOI
  10.1016/j.fct.2022.113586
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22K11824
[Journal Article] Haloperidol Prevents Oxytosis/Ferroptosis by Targeting Lysosomal Ferrous Ions in a Manner Independent of Dopamine D2 and Sigma-1 Receptors2022
- Author(s)
  Hirata Yoko、Oka Kohei、Yamamoto Shotaro、Watanabe Hiroki、Oh-hashi Kentaro、Hirayama Tasuku、Nagasawa Hideko、Takemori Hiroshi、Furuta Kyoji
- Journal Title
  
  ACS Chemical Neuroscience
  
  Volume: 13 Issue: 18 Pages: 2719-2727
- DOI
  10.1021/acschemneuro.2c00398
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22K11824, KAKENHI-PUBLICLY-22H04818, KAKENHI-PROJECT-23K23490
[Journal Article] Effect of ferroptosis inhibitors oxindole-curcumin hybrid compound and N,N-dimethylaniline derivatives on rotenone-induced oxidative stress2022
- Author(s)
  Hirata Yoko、Okazaki Ruidai、Sato Mina、Oh-hashi Kentaro、Takemori Hiroshi、Furuta Kyoji
- Journal Title
  
  European Journal of Pharmacology
  
  Volume: 928 Pages: 175119-175119
- DOI
  10.1016/j.ejphar.2022.175119
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22K11824
[Journal Article] Hormetic Effects of Binaphthyl Phosphonothioates as Pro-oxidants and Antioxidants2020
- Author(s)
  Hirata Yoko、Kuwabara Kazuma、Takashima Madoka、Murai Toshiaki
- Journal Title
  
  Chemical Research in Toxicology
  
  Volume: 33 Issue: 11 Pages: 2892-2902
- DOI
  10.1021/acs.chemrestox.0c00345
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19H02712
[Journal Article] Neuroprotective effects of(arylthio) cyclo-pentenone derivatives on manganese-induced apoptosis in PC12 cells2009
- Author(s)
  Shibata S., Maeda M., Furuta K., Suzuki M., Oh-Hashi K., Kiuchi K. and Hirata Y.
- Journal Title
  
  Brain Res
  
  Volume: Vol.1294 Pages: 218-225
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21500348
[Journal Article] (Arylthio) cyclopentenones derivatives prevent glutamate-induced HT22 cell death through a PPAR gamma-dependent pathway2009
- Author(s)
  Shibata S., Furuta K., Maeda M., Suzuki M., Oh-Hashi K., Kiuchi K. and Hirata Y.
- Journal Title
  
  Brain Res
  
  Volume: Vol.1296 Pages: 196-202
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21500348
[Journal Article] Synthesls of Neuyoprotective Cyclopentenne Prostaglandin Analogs Suppresslon of Manganese-induced Apoptosis of PC12 Cells2007
- Author(s)
  K.Furuta, M.Maeda, Y.Hirata, S.Shibata, K.Kiuchi, M.Suzuki
- Journal Title
  
  Bioorg. Med. Chem. Lett. (in press)
- Data Source
  KAKENHI-PROJECT-17310124
[Journal Article] p44/42 MAP kinase and c-Jun N-terminal kinase contribute to the up-regulation of caspase-3 in manganese-induced apoptosis in PC12 cells2006
- Author(s)
  Yoshimasa Ito, Kentaro Oh-hashi, Kazutoshi Kiuchi, Yoko Hirata
- Journal Title
  
  Brain Research (in press)
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16500240
[Journal Article] p44/42 MAP kinase and c-Jun N-termmal kinase contribute to the up-regulation of caspase-3 in manganese-induced apoptosis in PC12 cells2006
- Author(s)
  Yoshimasa Ito, Kentaro Oh-hashi, Kazutoshi Kiuchi, Yoko Hirata
- Journal Title
  
  Brain Res (in press)
- Data Source
  KAKENHI-PROJECT-16500240
[Journal Article] Differential effect of nerve growth factor on dopaminergic neurotoxin-induced apoptosis2006
- Author(s)
  Yoko Hirata, Tomotaka Meguro, Kazutoshi Kiuchi
- Journal Title
  
  Journal of Neurochemistry (in press)
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16500240
[Journal Article] Rotenone and CCCP inhibit tyrosine hydroxylation m rat striatal slices2005
- Author(s)
  Yoko Hirata, Toshiharu Nagatsu
- Journal Title
  
  Toxicology 216
  
  Pages: 9-14
- Data Source
  KAKENHI-PROJECT-16500240
[Journal Article] Rotenone and CCCP inhibit tyrosine hydroxylation in rat striatal slices2005
- Author(s)
  Yoko Hirata, Toshiharu Nagatsu
- Journal Title
  
  Toxicology 216
  
  Pages: 9-14
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16500240
[Presentation] Chloroquine inhibits glutamate-induced death of a neuronal cell line by reducing reactive oxygen species through sigma-1 receptor2011
- Author(s)
  Y.HIRATA, M.S.M.ATTA, K.OH-HASHIl, H.YAMAMOTO, K.KIUCHI
- Organizer
  Society for Neuroscience(北米神経科学会)
- Place of Presentation
  Washington, D.C.
- Year and Date
  2011-11-13
- Data Source
  KAKENHI-PROJECT-21500348
[Presentation] (Arylthio) cyclopentenones derivatives prevent glutamate-induced HT22 cell death through a PPARγ-dependent pathway2010
- Author(s)
  Y.HIRATA, S.SHIBATA, K.FURUTA, M.SUZUKI, K.OH-HASHI, K.KIUCHI
- Organizer
  Society for Neuroscience, 40th Annual Meeting
- Place of Presentation
  San Diego (アメリカ)
- Year and Date
  2010-11-16
- Data Source
  KAKENHI-PROJECT-21500348
[Presentation] (Arylthio) cyclopentenones derivatives prevent glutamate-induced HT22 cell death through a PPARγ-dependent pathway2010
- Author(s)
  Hirata Y, Shibata S, Furuta K, Suzuki M, Oh-Hashi K, Kiuchi K
- Organizer
  Society for Neuroscience
- Place of Presentation
  San Diego
- Year and Date
  2010-11-16
- Data Source
  KAKENHI-PROJECT-21500348
[Presentation] C6細胞におけるシクロペンテノン型プロスタグランジン類縁体NEPP11による神経栄養因子の誘導2009
- Author(s)
  岡田文陽、古田享史、鈴木正昭、大橋憲太郎、木内一壽、平田洋子
- Organizer
  日本生化学会大会
- Place of Presentation
  神戸
- Year and Date
  2009-10-24
- Data Source
  KAKENHI-PROJECT-21500348

1. FURUTA Kyoji (40173538)

# of Collaborated Projects: 3 results

# of Collaborated Products: 6 results
2. KIUCHI Kazutoshi (30135339)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
3. Murai Toshiaki (70166239)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
4. 宇田川太郎 (70509356)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
5. 今井喜胤 (80388496)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. 竹森洋 (90273672)

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
7. 濱本明恵

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

HIRATA Youko 平田 洋子

平田 洋子 ヒラタ ヨウコ

HIRATA Yoko 平田 洋子

Research Projects

Research Products

Co-Researchers

Development of feroptosis inhibitors based on the novel antioxidative mechanismPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Development of syntehtic reactions based on the tetracoorinate phosphorus compounds with a chrality

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Up-regulation of glial cell line-derived neurotrophic factor by newly synthesized cyclopentenone derivatives : Studies on cellular mechanisms in vitro and effectiveness in vivoPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Synthesis and Application of Novel Cyclopentenone Molecular Probes with Neuroprotective Activity

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Studies of molecular mechanisms of rotenone-induced apoptosis and neurotrophic substances for dopaminergic neuronsPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Studies for the phosphorylation and signaling pathway of a transcription factor induced by neuronal defferentiationPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Structural features localizing the ferroptosis inhibitor GIF-2197-r to lysosomes2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Antiferroptotic Activities of Oxindole GIF-0726-r Derivatives: Involvement of Ferrous Iron Coordination and Free-Radical Scavenging Capacities2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Quercetin and resveratrol inhibit ferroptosis independently of Nrf2-ARE activation in mouse hippocampal HT22 cells,2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Haloperidol Prevents Oxytosis/Ferroptosis by Targeting Lysosomal Ferrous Ions in a Manner Independent of Dopamine D2 and Sigma-1 Receptors2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Effect of ferroptosis inhibitors oxindole-curcumin hybrid compound and N,N-dimethylaniline derivatives on rotenone-induced oxidative stress2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Hormetic Effects of Binaphthyl Phosphonothioates as Pro-oxidants and Antioxidants2020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Neuroprotective effects of(arylthio) cyclo-pentenone derivatives on manganese-induced apoptosis in PC12 cells2009

Author(s)

Journal Title

Data Source

[Journal Article] (Arylthio) cyclopentenones derivatives prevent glutamate-induced HT22 cell death through a PPAR gamma-dependent pathway2009

Author(s)

Journal Title

Data Source

HIRATA Youko 平田洋子

平田洋子ヒラタヨウコ

HIRATA Yoko 平田洋子