SAKAI Yasuo 坂井靖夫

… Alternative Names

坂井靖夫サカイヤスオ

Less

Researcher Number	50272315
Other IDs
Affiliation (based on the past Project Information) *help	2012: 大阪大学, 医学(系)研究科(研究院), 准教授 2009 – 2012: Osaka University, 医学系研究科, 准教授 2011: 大阪大学, 医学系・研究科, 准教授 2007 – 2008: Fujita Health University, 医学部, 准教授 1996: 千葉大学, 医学部・附属病院, 助手 1996: 千葉大学, 医学部附属病院, 助手
Review Section/Research Field	Principal Investigator Plastic surgery / General anatomy (including Histology/Embryology) / Dermatology Except Principal Investigator Dermatology / Plastic surgery / General anatomy (including Histology/Embryology)
Keywords	Principal Investigator レチノイン酸 / 発生 / 再生 / 毛 / 創傷治愈 / CYP26B1 / 創傷治癒 / 毛発生 / 皮膚発生 / 舌 … More / 遺伝子改変マウス / CYP26 / 口蓋裂 / mRNA / in situ hybridiration / ウロキナーゼタイプ・プラスミノーゲンアクチベータ- / マトリックス・メタロプロテナーゼ / 細胞外マトリックス / 皮膚有棘細胞癌 … More Except Principal Investigator CYP26B1 / レチノイン酸 / transcription / TGF beta receptor / TGF beta / Pur beta / Pur alpha / promoter gene / type I collagen / 皮膚線維症 / COLF1 / TNF-α / 遺伝子発現 / TGFβレセプター / TGFβ / Purβ / Purα / 転写 / TGF βレセプター / TGF β / Pur β / Pur α / プロモーター遺伝子 / I型コラーゲン / glycosaminoglycans / actinic keratosis / matrix metalloproteinase / extracellular matrix / skin cancer / ムコ多糖 / 日光角化症 / マトリックスメタロプロテアーゼ / 細胞外マトリックス / 皮膚悪性腫瘍 / 再生医療 / 骨形成 / 軟骨形成 / CYP26 / 頭蓋顔面骨 / 軟骨発生 / 骨発生 / 毛包発生 / ノックアウトマウス / 皮膚発生 / プロテオグリカン / デコリン / コラーゲン線維 / デルマトポンチン Less

毛の発生と維持にレチノイン酸はどう関わるか?Principal Investigator
- Principal Investigator
  
  坂井靖夫
- Project Period (FY)
  2012
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Plastic surgery
- Research Institution
  Osaka University
Role of retinoic acid in craniofacial bone formation
- Principal Investigator
  
  HOSOKAWA Ko
- Project Period (FY)
  2010 – 2012
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Plastic surgery
- Research Institution
  Osaka University
Role of retinoic acid in the mechanism of skin wound healingPrincipal Investigator
- Principal Investigator
  
  SAKAI Yasuo
- Project Period (FY)
  2009 – 2011
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Plastic surgery
- Research Institution
  Osaka University
Cyp26(レチノイン酸分解酵素)の役割を中心とした皮膚発生における分子機構
- Principal Investigator
  
  岡野純子
- Project Period (FY)
  2008 – 2010
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  General anatomy (including Histology/Embryology)
- Research Institution
  Kyoto University
Role of CYP26B1, a retinoic acid inactivating enzyme, in cleft palate formationPrincipal Investigator
- Principal Investigator
  
  SAKAI Yasuo
- Project Period (FY)
  2007 – 2008
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  General anatomy (including Histology/Embryology)
- Research Institution
  Fujita Health University
コラーゲン線維化におけるデルマトポンチン(新しい細胞外マトリックス成分)の機能
- Principal Investigator
  
  SHINKAI Hiroshi
- Project Period (FY)
  1996
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Dermatology
- Research Institution
  Chiba University
皮膚癌細胞における細胞外マトリックス関連遺伝子の組織内発現および局在Principal Investigator
- Principal Investigator
  
  坂井靖夫
- Project Period (FY)
  1996
- Research Category
  
  Grant-in-Aid for Encouragement of Young Scientists (A)
- Research Field
  
  Dermatology
- Research Institution
  Chiba University
The expression of extracellular matrix-related genes in skin cancers
- Principal Investigator
  
  TSUKIFUJI Reiko
- Project Period (FY)
  1996 – 1997
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Dermatology
- Research Institution
  Chiba University
Transcriptional control mechanism for the expression of type I collagen gene in fibrotic skin disorders and related diseases
- Principal Investigator
  
  HATAMOCHI Atsushi
- Project Period (FY)
  1996 – 1997
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Dermatology
- Research Institution
  Chiba University

All 2012 2011 2010 2009 2008 2007 Other

All Journal Article Presentation Book

[Book] Methods in Molecular Biology (Detection of retinoic acid catabolism with receptor systems and by in situ hybridization)2010
- Author(s)
  Sakai Y, Drager U
- Publisher
  Springer
- Data Source
  KAKENHI-PROJECT-21390480
[Book] Detection of retinoic acid catabolism with reporter systems and by in situ hybridization for CYP26 enzymes2010
- Author(s)
  Sakai Y, Drager UC
- Publisher
  Methods Mol Biol
- Data Source
  KAKENHI-PROJECT-21390480
[Book] Detection of Retinic Acid Catabolism with Reporter Systems and by In Situ Hybridization for CYP26 Enzymes. (Methods in Molecular Biology)2009
- Author(s)
  Sakai Y, Drager UC
- Publisher
  Hamana Press Inc. (Totowa, NJ, USA)(印刷中)
- Data Source
  KAKENHI-PROJECT-19590181
[Book] Detection of Retinic Acid Catabolism with Reporter Systems and by In Situ Hybridization for CYP26 Enzymes. Methods in Molecular Biology
- Author(s)
  Sakai Y, Drager UC.
- Publisher
  Hamana Press Inc(Totowa, NJ, USA), in press
- Data Source
  KAKENHI-PROJECT-19590181
[Journal Article] Increased retinoic acid levels through ablation of Cyp26b1 determine the processes of embryonic skin barrier formation and peridermal development2012
- Author(s)
  Okano J et al.(Sakai Y ; 9人中8番)
- Journal Title
  
  J Cell Sci
  
  Volume: 125 Pages: 1827-36
- DOI
  10.1242/jcs.101550
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21390480, KAKENHI-PROJECT-22591991
[Journal Article] bFGF regulates P13-kinase-Rac1-JNK pathway and promotes fibroblast migration in wound healing.2010
- Author(s)
  Kanazawa S, et al., (Hosokawa K, Sakai Y)
- Journal Title
  
  PLoS One
  
  Volume: 5
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22591991
[Journal Article] bFGF regulates PI3-kinase-Rac1-JNK pathway and promotes fibroblast migration in wound healing2010
- Author(s)
  Kanazawa S et al.(Sakai Y ; 11人中8番)
- Journal Title
  
  PLoS One
  
  Volume: 5 Issue: 8 Pages: e12228-e12228
- DOI
  10.1371/journal.pone.0012228
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21390480
[Journal Article] bFGF regulates P13-kinase-Racl-JNK pathway and promotes fibroblast migration in wound healing.2010
- Author(s)
  Kanazawa S, et al.(Sakai Y)
- Journal Title
  
  PLoS One
  
  Volume: 5
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21390480
[Journal Article] Correlation of axillary osmidrosis to a SNP in the ABCC11 gene determined by the Smart Amplification Process (SmartAmp) method.2009
- Author(s)
  Inoue Y, et al. (Sakai Y)
- Journal Title
  
  J Plast Reconstr Aesthet Surh In press(In press)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21390480
[Journal Article] Earwax, osmidrosis, and breast cancer : why does one SNP (538G>A) in the human ABC transporter ABCC11 gene determine earwax type?2009
- Author(s)
  Toyoda Y, et al. (Sakai Y)
- Journal Title
  
  FASED J 23
  
  Pages: 2001-2013
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21390480
[Journal Article] Retinoic acid down-regulates Tbx1 expression and induces abnormal differentiation of tongue muscles in fetal mice2008
- Author(s)
  Okano J, Sakai Y, Shiota K.
- Journal Title
  
  Dev Dyn 237
  
  Pages: 3059-70
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590181
[Journal Article] Retinoic acid down-regulates Tbx1 expression and induces abnormal differentiation of tongue muscles in fetal mice.2008
- Author(s)
  Okano J, Sakai Y, Shiota K
- Journal Title
  
  Developmental Dynamics 237
  
  Pages: 3059-3070
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590181
[Presentation] 、レチノイン酸は生体内において成長板増殖軟骨細胞の細胞増殖を抑制する2012
- Author(s)
  峯岸芳樹ほか(細川亙、坂井靖夫)
- Organizer
  第21回日本形成外科学会基礎学術集会
- Place of Presentation
  猪苗代
- Year and Date
  2012-10-05
- Data Source
  KAKENHI-PROJECT-22591991
[Presentation] やさしい分子生物学-3次元的に標的物質を視る2011
- Author(s)
  坂井靖夫
- Organizer
  第20回日本形成外科学会基礎学術集会
- Place of Presentation
  東京(教育シンポジウム)(招待講演)
- Year and Date
  2011-10-06
- Data Source
  KAKENHI-PROJECT-21390480
[Presentation] やさしい分子生物学-3次元的に標的物質を視る(教育シンポジウム)2011
- Author(s)
  坂井靖夫
- Organizer
  第20回日本形成外科学会基礎学術集会(招待講演)
- Place of Presentation
  東京
- Year and Date
  2011-10-06
- Data Source
  KAKENHI-PROJECT-21390480
[Presentation] Effect of retinoic acid on cleft palate formation2011
- Author(s)
  Sakai Y, et al
- Organizer
  the 16th Congress of the International Confederation of Plastic Reconstructive and Aesthetic Surgery
- Place of Presentation
  Vancouver (Canada)
- Year and Date
  2011-05-23
- Data Source
  KAKENHI-PROJECT-21390480
[Presentation] Increased endogenous retinoic acid by the absence of Cyp26b1 impairs peridermal development and skin barrier formation during development.2011
- Author(s)
  Okano J et al.(Sakai Y)
- Organizer
  2011 AnnualMeeting of Society of Investigative Dermatology
- Place of Presentation
  Phoenix(USA)
- Year and Date
  2011-05-04
- Data Source
  KAKENHI-PROJECT-21390480
[Presentation] Cyp26b1遺伝子欠損マウスは皮膚のバリア機能が障害される2011
- Author(s)
  坂井靖夫, ほか
- Organizer
  第20回日本形成外科学会基礎学術集会
- Place of Presentation
  東京
- Year and Date
  2011-10-06
- Data Source
  KAKENHI-PROJECT-21390480
[Presentation] Increased endogenous retinoic acid by the absence of Cyp26b1 impairs peridermal development and skin barrier formation during development2011
- Author(s)
  Okano J, et al. (Sakai Y)
- Organizer
  2011 Annual Meeting of Society of Investigative Dermatology
- Place of Presentation
  Phenix (USA)
- Year and Date
  2011-05-04
- Data Source
  KAKENHI-PROJECT-21390480
[Presentation] 内軟骨性骨化におけるレチノイン酸の役割2011
- Author(s)
  峯岸芳樹ほか(細川亙、坂井靖夫)
- Organizer
  第20回日本形成外科学会基礎学術集会
- Place of Presentation
  東京
- Year and Date
  2011-10-06
- Data Source
  KAKENHI-PROJECT-22591991
[Presentation] 発生学を基盤とした先天異常疾患に対するアプローチ(主題シンポジウム)2010
- Author(s)
  坂井靖夫、細川亙
- Organizer
  第19回日本形成外科学会基礎学術集会
- Place of Presentation
  横浜(招待講演)
- Year and Date
  2010-09-17
- Data Source
  KAKENHI-PROJECT-21390480
[Presentation] Retinoic acid induces cleft palate by suppressing Fgf10 in the bend region of the palatal shelves.2010
- Author(s)
  Sakai Y, et al.
- Organizer
  Plastic Surgery 2010
- Place of Presentation
  Toronto (Canada)
- Year and Date
  2010-10-01
- Data Source
  KAKENHI-PROJECT-21390480
[Presentation] Retinoic acid induces cleft palate by suppressing Fgf10 in the bend region of the palatal shelves2010
- Author(s)
  Sakai Y et al.
- Organizer
  Plastic Surgery 2010
- Place of Presentation
  Toronto(Canada)
- Year and Date
  2010-10-01
- Data Source
  KAKENHI-PROJECT-21390480
[Presentation] 発生学を基盤とした先天異常疾患に対するアプローチ(主題シンポジウム)2010
- Author(s)
  坂井靖夫、細川亙
- Organizer
  第19回日本形成外科学会基礎学術集会(招待講演)
- Place of Presentation
  横浜
- Year and Date
  2010-09-17
- Data Source
  KAKENHI-PROJECT-21390480
[Presentation] 発生学を基盤とした先天異常疾患に対するアプローチ(主題シンポジウム)2010
- Author(s)
  坂井靖夫、細川亙
- Organizer
  第19回日本形成外科学会基礎学術集会
- Place of Presentation
  横浜(招待講演)
- Year and Date
  2010-09-17
- Data Source
  KAKENHI-PROJECT-22591991
[Presentation] 発生学を基盤とした先天異常疾患に対するアプローチ(主題シンポジウム)2010
- Author(s)
  坂井靖夫、細川亙
- Organizer
  第19回日本形成外科学会基礎学術集会
- Place of Presentation
  横浜
- Year and Date
  2010-09-17
- Data Source
  KAKENHI-PROJECT-22591991
[Presentation] 口蓋発生におけるCYP26B1(レチノイン酸不活化酵素)の役割2009
- Author(s)
  坂井靖夫
- Organizer
  第18回日本形成外科学会基礎学術集会
- Place of Presentation
  東京
- Year and Date
  2009-10-02
- Data Source
  KAKENHI-PROJECT-21390480
[Presentation] 毛包発生におけるCYP26B1(レチノイン酸不活化酵素)の役割-第2報-2009
- Author(s)
  小池学、坂井靖夫, ほか
- Organizer
  第18回日本形成外科学会基礎学術集会
- Place of Presentation
  東京
- Year and Date
  2009-10-02
- Data Source
  KAKENHI-PROJECT-21390480
[Presentation] 毛包発生におけるCYP26B1 (レチノイン酸不活化酵素)の役割-第1報-2008
- Author(s)
  小池学, 大杉育子, 吉村陽子, 坂井靖夫
- Organizer
  第17回日本形成外科学会基礎学術集会
- Place of Presentation
  東京
- Year and Date
  2008-10-02
- Data Source
  KAKENHI-PROJECT-19590181
[Presentation] 毛包発生におけるCYP26B1(レチノイン酸不活化酵素)の役割-第1報-2008
- Author(s)
  小池学、大杉育子、吉村陽子、坂井靖夫
- Organizer
  第17回日本形成外科学会基礎学術集会
- Place of Presentation
  東京
- Year and Date
  2008-10-02
- Data Source
  KAKENHI-PROJECT-19590181
[Presentation] CYP26B1(レチノイン酸不活化酵素)は正常な舌発生に必須である2008
- Author(s)
  坂井靖夫、岡野純子、塩田浩平、大杉育子、小池学、吉村陽子
- Organizer
  第17回日本形成外科学会基礎学術集会
- Place of Presentation
  東京
- Year and Date
  2008-10-03
- Data Source
  KAKENHI-PROJECT-19590181
[Presentation] Retinoic acid causes down-regulation of Tbx1 expression and aberrant morphogenesis in the fetal mouse tongue2008
- Author(s)
  Okano J, Sakai Y, Shiota K
- Organizer
  Plastic Surgery 2008(全米形成外科学会)
- Place of Presentation
  Chicago (USA)
- Year and Date
  2008-10-31
- Data Source
  KAKENHI-PROJECT-19590181
[Presentation] Retinoic acid causes down-regulation of Tbx1 expression and aberrant morphogenesis in the fetal mouse tongue.2008
- Author(s)
  Okano J, Sakai Y, Shiota K
- Organizer
  Plastic Surgery 2008 (全米形成外科学会)
- Place of Presentation
  Chicago (USA)
- Year and Date
  2008-10-31
- Data Source
  KAKENHI-PROJECT-19590181
[Presentation] Roles of retinoic acid in tongue development in mice2008
- Author(s)
  岡野純子、坂井靖夫、塩田浩平
- Organizer
  第48回日本先天異常学会
- Place of Presentation
  東京
- Year and Date
  2008-06-28
- Data Source
  KAKENHI-PROJECT-19590181
[Presentation] Roles of retinoic acid in tongue development in mice.2008
- Author(s)
  岡野純子, 坂井靖夫, 塩田浩平
- Organizer
  第48回日本先天異常学会
- Place of Presentation
  東京
- Year and Date
  2008-06-28
- Data Source
  KAKENHI-PROJECT-19590181
[Presentation] The retinoic acid-inactivating enzyme CYP26B1 is essential for craniofacial and palate formation in mouse development2007
- Author(s)
  Yasuo Sakai, Yohko Yoshimura
- Organizer
  第14回国際形成外科学会
- Place of Presentation
  ベルリン(ドイツ)
- Year and Date
  2007-06-26
- Data Source
  KAKENHI-PROJECT-19590181

1. HATAMOCHI Atsushi (90172923)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
2. SHINKAI Hiroshi (90030957)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
3. KURODA Kei (90225300)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
4. TSUKIFUJI Reiko (70218048)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
5. ITAMT Satoshi (30136791)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
6. HOSOKAWA Ko (20181498)

# of Collaborated Projects: 2 results

# of Collaborated Products: 5 results
7. KISHI Kazuo (40224919)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. YOSHIMURA Yoko (20129737)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. INOUE Yoshikazu (80340264)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
10. MATSUDA Ken (50423166)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. KIKUCHI Mamoru (20437677)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
12. 岡野純子 (50447968)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
13. 塩田浩平 (80109529)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results

SAKAI Yasuo 坂井 靖夫

坂井 靖夫 サカイ ヤスオ

Research Projects

Research Products

Co-Researchers

毛の発生と維持にレチノイン酸はどう関わるか?Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Role of retinoic acid in craniofacial bone formation

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Role of retinoic acid in the mechanism of skin wound healingPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Cyp26(レチノイン酸分解酵素)の役割を中心とした皮膚発生における分子機構

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Role of CYP26B1, a retinoic acid inactivating enzyme, in cleft palate formationPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

コラーゲン線維化におけるデルマトポンチン(新しい細胞外マトリックス成分)の機能

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

皮膚癌細胞における細胞外マトリックス関連遺伝子の組織内発現および局在Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

The expression of extracellular matrix-related genes in skin cancers

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Transcriptional control mechanism for the expression of type I collagen gene in fibrotic skin disorders and related diseases

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Book] Methods in Molecular Biology (Detection of retinoic acid catabolism with receptor systems and by in situ hybridization)2010

Author(s)

Publisher

Data Source

[Book] Detection of retinoic acid catabolism with reporter systems and by in situ hybridization for CYP26 enzymes2010

Author(s)

Publisher

Data Source

[Book] Detection of Retinic Acid Catabolism with Reporter Systems and by In Situ Hybridization for CYP26 Enzymes. (Methods in Molecular Biology)2009

Author(s)

Publisher

Data Source

[Book] Detection of Retinic Acid Catabolism with Reporter Systems and by In Situ Hybridization for CYP26 Enzymes. Methods in Molecular Biology

Author(s)

Publisher

Data Source

[Journal Article] Increased retinoic acid levels through ablation of Cyp26b1 determine the processes of embryonic skin barrier formation and peridermal development2012

Author(s)

Journal Title

DOI

Data Source

SAKAI Yasuo 坂井靖夫

坂井靖夫サカイヤスオ