KAWAKAMI Junichi 川上純一

… Alternative Names

川上純一カワカミジユンイチ

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Researcher Number	50272539
Other IDs
Affiliation (Current)	2022: 浜松医科大学, 医学部附属病院, 教授
Affiliation (based on the past Project Information) *help	2009 – 2021: Hamamatsu University School of Medicine, 医学部附属病院, 教授 2015: 浜松医科大学, 医学部附属病院, 教授・薬剤部長 2011: 浜松医科大学, 医学部・附属病院, 教授 2006 – 2007: 浜松医科大学, 医学部附属病院, 教授 2005: 富山大学, 附属病院, 助教授 2001 – 2004: 富山医科薬科大学, 附属病院, 助教授 1997 – 1998: 東京大学, 医学部・附属病院, 助手
Review Section/Research Field	Principal Investigator Medical pharmacy / 応用薬理学・医療系薬学 / Basic Section 47060:Clinical pharmacy-related Except Principal Investigator Medical pharmacy / Basic Section 47060:Clinical pharmacy-related
Keywords	Principal Investigator 炎症性サイトカイン / 薬物動態 / がん性疼痛 / がん悪液質 / オピオイド / 血液脳関門 / 有害作用 / 薬物間相互作用 / TNFα / IL-1β … More / 緩和医療 / 代謝物 / 遺伝子多型 / 神経障害性疼痛 / トラマドール / プレガバリン / ニューキノロン系抗菌剤 / 非ステロイド性抗炎症剤 / 副作用 / GABA_A受容体 / けいれん / アフリカツメガエル卵母細胞 / mRNA / GABAA受容体 / 痙攣 / 脳毛細血管内皮細胞 / アストロサイト / 共培養 / 多発性硬化症 / 実験的自己免疫性脳脊髄炎ラット / 酸化ストレス / in vitro / 解熱鎮痛剤 / インフルエンザ脳炎 / インフルエンザ脳症 / PGE_2 / 中枢神経系 / 非ステロイド性抗炎症薬 / インフルエンザウイルス / 脳血管 / 薬剤性痙攣 / 中枢移行性 / 脳虚血 / 薬剤性痙彎 / オピオイド鎮痛薬 / オキシコドン / オーダーメイド医療 / 遺伝子多 / 悪液質 / 耐性形成 / 遊離形分率 / 有害反応 / アルブミン / α1酸性糖タンパク / CYP2D6 / ガバペンチン / 遺伝子変異 / 制酸剤 / がん病期 / 鎮痛効果 / 病期 / 薬物代謝 / 忍容性 / フェンタニル / 鎮痛補助薬 / バイオマーカー / デュロキセチン / 神経障害性疼痛治療薬 / 個別化薬物療法 / オピオイド誘発性便秘 / がん性疼痛緩和 / 薬物代謝酵素 / 薬物輸送担体 / オピオイド系鎮痛薬 / がん病態生理 … More Except Principal Investigator 薬物動態 / 炎症性サイトカイン / オピオイド / がん性疼痛 / 薬物代謝 / バイオマーカー / 医療情報データベース / 薬物間相互作用 / 免疫バイオ医薬品 / スタチン / 免疫関連バイオ医薬品 / 悪液質 / オキシコドン / サイトカイン / 中枢症状 / 有害作用 / がん悪液質 / 薬剤疫学 / 糖尿病治療薬 / DPP4阻害薬 / 尿路感染症 / 副作用 / 糖尿病薬 / 薬物代謝酵素 / 遺伝子多型 / 炎症 / CYP3A4 / CYP2D6 / 血清バイオマーカー / 4β水酸化コレステロール / マイクロRNA / CYP3A4/5 / エピジェネティック因子 / CYP3A / 個別化薬物療法 / 低分子分子標的薬 / ヤヌスキナーゼ阻害 / 体内動態 / JAK-STAT / ヤヌスキナーゼ阻害薬 / 投与設計 / 甲状腺ホルモン / 妊娠 / 肝取り込みトランスポーター / 有機アニオン輸送ポリペプチド / 周産期 / トランスポーター Less

Investigation of interindividual factors determining the clinical effects of peripherally-acting mu-opioid receptor antagonist under cancer conditionsPrincipal Investigator
- Principal Investigator
  
  川上純一
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 47060:Clinical pharmacy-related
- Research Institution
  Hamamatsu University School of Medicine
PK-PD解析に基づく自己免疫疾患に対する低分子分子標的薬の投与設計法の確立
- Principal Investigator
  
  見野靖晃
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 47060:Clinical pharmacy-related
- Research Institution
  Hamamatsu University School of Medicine
Kinetic analyses of thyroid hormone based on hepatic uptake transporter activity during the perinatal period
- Principal Investigator
  
  内藤隆文
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 47060:Clinical pharmacy-related
- Research Institution
  Shinshu University
  Hamamatsu University School of Medicine
Investigation of interindividual variability in pharmacokinetics of and clinical responses to neuropathic pain medications in cancer patientsPrincipal Investigator
- Principal Investigator
  
  Kawakami Junichi
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 47060:Clinical pharmacy-related
- Research Institution
  Hamamatsu University School of Medicine
Prediction of opioid analgesics pharmacokinetics using the biomarkers of drug metabolizing enzyme activity in cancer patients
- Principal Investigator
  
  NAITO TAKAFUMI
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Medical pharmacy
- Research Institution
  Hamamatsu University School of Medicine
Prediction of interindividual variations in pain relief and adverse effects of opioid analgesics based on cancer disease stagePrincipal Investigator
- Principal Investigator
  
  Kawakami Junichi
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Medical pharmacy
- Research Institution
  Hamamatsu University School of Medicine
The pharmacoepidemiological study on the adverse reaction of novel therapeutic agent for type 2 diabetes mellitus and the application
- Principal Investigator
  
  Imatoh Takuya
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Medical pharmacy
- Research Institution
  National Institute of Health Sciences
Investigation of interindividual factors determining the pain relief and adverse effects of opioid analgesics in cancer cachexia
- Principal Investigator
  
  NAITO TAKAFUMI
- Project Period (FY)
  2014 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Medical pharmacy
- Research Institution
  Hamamatsu University School of Medicine
Evaluation of interaction between biotechnology-based drug and chemical drug using medical information databases
- Principal Investigator
  
  SAI KIMIE
- Project Period (FY)
  2013 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Medical pharmacy
- Research Institution
  National Institute of Health Sciences
Investigation of interindividual variability in pharmacokinetics of and clinical responses to analgesics for cancer pain reliefPrincipal Investigator
- Principal Investigator
  
  KAWAKAMI Junichi
- Project Period (FY)
  2012 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Medical pharmacy
- Research Institution
  Hamamatsu University School of Medicine
Investigation of interindividual variability in pharmacokinetics of and clinical responses to opioid analgesics in cancer pain patientsPrincipal Investigator
- Principal Investigator
  
  KAWAKAMI Junichi
- Project Period (FY)
  2009 – 2011
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Medical pharmacy
- Research Institution
  Hamamatsu University School of Medicine
病態時における血液脳関門の破綻と医薬品による中枢神経系副作用の発現との関係解明Principal Investigator
- Principal Investigator
  
  川上純一
- Project Period (FY)
  2005 – 2007
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Medical pharmacy
- Research Institution
  Hamamatsu University School of Medicine
  University of Toyama
解熱鎮痛剤によるインフルエンザ脳炎・脳症の重症化に関する機構解明Principal Investigator
- Principal Investigator
  
  川上純一
- Project Period (FY)
  2003 – 2004
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Medical pharmacy
- Research Institution
  Toyama Medical and Pharmaceutical University
中枢神経系疾患による血液脳関門の機能変化と制御機構の解明Principal Investigator
- Principal Investigator
  
  川上純一
- Project Period (FY)
  2001 – 2002
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  応用薬理学・医療系薬学
- Research Institution
  Toyama Medical and Pharmaceutical University
ニューキノロン剤と非ステロイド性抗炎症剤との相互作用の機構解明Principal Investigator
- Principal Investigator
  
  川上純一
- Project Period (FY)
  1997 – 1998
- Research Category
  
  Grant-in-Aid for Encouragement of Young Scientists (A)
- Research Field
  
  応用薬理学・医療系薬学
- Research Institution
  The University of Tokyo

All 2021 2020 2019 2017 2016 2012 2011 2010 2009

All Journal Article Presentation

[Journal Article] A reversed-phase mode LC-MS/MS method using a polysaccharide chiral selector for simultaneous quantitation of each enantiomer of tramadol and its metabolites in human plasma and evaluation of CYP-mediated stereoselective demethylation.2020
- Author(s)
  Suzuki K, Naito T, Tanaka H, Yamada Y, Itoh K, Kawakami J.
- Journal Title
  
  Ther Drug Monit
  
  Volume: －
- DOI
  10.1097/ftd.0000000000000707
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K08410
[Journal Article] Impact of cachexia and opioid analgesic co-treatment on pregabalin pharmacokinetics and central nervous system symptoms in cancer patients.2019
- Author(s)
  Nozomi Yoshikawa, Takafumi Naito, Tatsuya Yagi, and Junichi Kawakami
- Journal Title
  
  Ther Drug Monit
  
  Volume: 41 Pages: 591-597
- DOI
  10.1097/ftd.0000000000000634
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18H00378, KAKENHI-PROJECT-18K06746
[Journal Article] Relationships between oxycodone pharmacokinetics, central symptoms, and serum interleukin-6 in cachectic cancer patients2016
- Author(s)
  Sato H, Naito T, Ishida T, Kawakami J.
- Journal Title
  
  Eur J Clin Pharmacol
  
  Volume: 72(12) Pages: 1463-1470
- DOI
  10.1007/s00228-016-2116-z
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-26460194
[Journal Article] Impact of Concomitant Antacid Administration on Gabapentin Plasma Exposure and Oral Bioavailability in Healthy Adult Subjects2012
- Author(s)
  Yagi T, Naito T, Mino Y, Umemura K, Kawakami J.
- Journal Title
  
  DMPK
  
  Volume: 27 Issue: 2 Pages: 248-254
- DOI
  10.2133/dmpk.dmpk-11-rg-108
  10.2133/dmpk.DMPK-11-RG-108
- NAID
  130004463244
- ISSN
  1347-4367, 1880-0920
- Language
  English
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24590186
[Journal Article] Impact of cachexia on pharmacokinetic disposition of and clinical responses to oxycodone in cancer patients2012
- Author(s)
  Naito T, Tashiro M, Yamamoto K, Ohnishi K, Kagawa Y, Kawakami J
- Journal Title
  
  Eur J Clin Pharmacol
  
  Volume: (in press)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590155
[Journal Article] CYP3A5* 3 affects plasma disposition of noroxycodone and dose escalation in cancer patients receiving oxycodone2011
- Author(s)
  Naito T, Takashina Y, Yamamoto K, Tashiro M, Ohnishi K, Kagawa Y, Kawakami J
- Journal Title
  
  J Clin Pharmacol
  
  Volume: 51 Pages: 1529-1538
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590155
[Presentation] メタルフリーPEEKカラムを用いたOATP1B基質胆汁酸硫酸抱合体のLC-MS/MS同時定量法の開発2021
- Author(s)
  黒澤優子, 内藤隆文, 前川真人, 伊東宏晃, 川上純一
- Organizer
  第42回日本臨床薬理学会学術総会
- Data Source
  KAKENHI-PROJECT-20K07175
[Presentation] 頭頸部がん患者におけるトラマドール及び代謝物の光学異性体の血中動態とCYP2D6のactivity scoreとの関係解析.2020
- Author(s)
  鈴木光路, 内藤隆文, 田中達也, 山田康秀, 伊藤邦彦, 川上純一.
- Organizer
  第140回日本薬学会年会
- Data Source
  KAKENHI-PROJECT-17K08410
[Presentation] デュロキセチン服用妊婦における臍帯血・母体血中薬物濃度と新生児薬物離脱症候群との関係2020
- Author(s)
  田口怜奈, 内藤隆文, 鈴木光路, 伊東宏晃, 川上純一
- Organizer
  第30回日本医療薬学会年会
- Data Source
  KAKENHI-PROJECT-18K06746
[Presentation] An enantiomeric quantitation of tramadol and its metabolites in human plasma and evaluation of cytochrome P450-mediated stereoselective demethylation.2019
- Author(s)
  Suzuki K, Naito T, Tanaka H, Yamada Y, Itoh K, Kawakami J.
- Organizer
  The 120th Annual Meeting of the American Society for Clinical Pharmacology and Therapeutics (ASCPT2019)
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K08410
[Presentation] がん患者におけるトラマドールとその脱メチル代謝物の血中動態に及ぼすCYP2D6およびCYP2B6の遺伝子変異の影響2017
- Author(s)
  田中達也, 内藤隆文, 佐藤聖, 川上純一
- Organizer
  第38回日本臨床薬理学会年会
- Data Source
  KAKENHI-PROJECT-15K08070
[Presentation] Impact of CYP2D6 phenotype on tramadol pharmacokinetics and metabolic pathways in cancer patients2017
- Author(s)
  Tanaka H, Naito T, Sato H, Kawakami J
- Organizer
  13th Congress of the European Association for Clinical Pharmacology and Therapeutics (EACPT2017
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K08070
[Presentation] がん悪液質の病態時における血清IL-6 の濃度上昇とオキシコドンの血中動態および中枢症状発現との関係2016
- Author(s)
  佐藤聖, 内藤隆文, 石田卓矢, 川上純一.
- Organizer
  第26回日本医療薬学会年会
- Place of Presentation
  京都市
- Year and Date
  2016-09-17
- Data Source
  KAKENHI-PROJECT-26460194
[Presentation] Impact of serum albumin level on free oxycodone pharmacokinetics, dose escalation, and central adverse reaction in cancer patients2011
- Author(s)
  Naito T, Tashiro M, Yamamoto K, Kagawa Y, Kawakami J
- Organizer
  10th Congress of the European Association for Clinical Pharmacology and Therapeutics
- Place of Presentation
  Budapest, Hungary
- Data Source
  KAKENHI-PROJECT-21590155
[Presentation] Impact of cachexia on pharmacokinetic disposition of and clinical responses to oxycodone in cancer patients2011
- Author(s)
  Naito T, Tashiro M, Yamamoto K, Ohnishi K, Kagawa Y, Kawakami J
- Organizer
  第5回次世代を担う若手医療薬科学シンポジウム
- Place of Presentation
  名古屋
- Data Source
  KAKENHI-PROJECT-21590155
[Presentation] がん悪液質のステージ分類に基づくオキシコドンの体内動態および臨床効果の個人差の評価2011
- Author(s)
  内藤隆文, 田代将貴, 山本圭祐, 賀川義之, 川上純一
- Organizer
  第32回日本臨床薬理学会年会
- Place of Presentation
  浜松市
- Year and Date
  2011-12-02
- Data Source
  KAKENHI-PROJECT-21590155
[Presentation] がん悪液質のステージ分類に基づくオキシコドンの体内動態および臨床効果の個人差の評価2011
- Author(s)
  内藤隆文,田代将貴,山本圭祐,賀川義之,川上純一
- Organizer
  第32回日本臨床薬理学会年会
- Place of Presentation
  浜松
- Data Source
  KAKENHI-PROJECT-21590155
[Presentation] Impact of CYP2D6and CYP3A5gene polymorphisms on pharmacokinetics of oxycodone and its demethylates and dose escalation rate in cancer patients2010
- Author(s)
  Naito T, Yamamoto K, Takashina Y, Tashiro M, Kagawa Y, Ohnishi K, Kawakami J
- Organizer
  16th World Congress of Basic and Clinical Pharmacology(WorldPharma2010)
- Place of Presentation
  Copenhagen, Denmark
- Data Source
  KAKENHI-PROJECT-21590155
[Presentation] がん患者におけるオキシコドンとその代謝物の血中動態と嘔吐出現-CYP2D6, CYP3A5, ABCB1およびOPRM1の遺伝子変異の影響-2010
- Author(s)
  田代将貴,内藤隆文,山本圭祐,高科嘉章,賀川義之,川上純一
- Organizer
  第130回日本薬学会年会
- Place of Presentation
  岡山
- Data Source
  KAKENHI-PROJECT-21590155
[Presentation] CYP3A5* 3 affects plasma disposition of noroxycodone and dose escalation in cancer patients receiving oxycodone2010
- Author(s)
  Takashina Y, Naito T, Tashiro M, Yamamoto K, Ohnishi K, Kagawa Y, Kawakami J
- Organizer
  第4回次世代を担う若手医療薬科学シンポジウム
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-21590155
[Presentation] がん患者におけるオキシコドンとその代謝物の血中動態と嘔吐出現-CYP2D6、CYP3A5、ABCB1およびOPRM1の遺伝子変異の影響-2010
- Author(s)
  内藤隆文, 川上純一, ら
- Organizer
  日本薬学会年会
- Place of Presentation
  岡山コンベンションセンター (岡山)
- Year and Date
  2010-03-28
- Data Source
  KAKENHI-PROJECT-21590155
[Presentation] がん患者におけるオキシコドンの有害作用と耐性形成に及ぼすCYP3A5, CYP2D6およびOPRM1の遺伝子変異の影響2009
- Author(s)
  山本圭祐,内藤隆文,高科嘉章,丸山修治,賀川義之,川上純一
- Organizer
  第30回日本臨床薬理学会年会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-21590155

1. NAITO Takafumi (80422749)

# of Collaborated Projects: 8 results

# of Collaborated Products: 22 results
2. HORI KATSUHITO (20436786)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
3. TANAKA Hironari

# of Collaborated Projects: 2 results

# of Collaborated Products: 2 results
4. ISHIDA Takuya

# of Collaborated Projects: 2 results

# of Collaborated Products: 2 results
5. YAGI Tatsuya (70719575)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
6. SAI KIMIE (20195960)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. Imatoh Takuya (20368989)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. 見野靖晃 (40586715)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. SATO Hikaru

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results

KAWAKAMI Junichi 川上 純一

川上 純一 カワカミ ジユンイチ

Research Projects

Research Products

Co-Researchers

Investigation of interindividual factors determining the clinical effects of peripherally-acting mu-opioid receptor antagonist under cancer conditionsPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

PK-PD解析に基づく自己免疫疾患に対する低分子分子標的薬の投与設計法の確立

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Kinetic analyses of thyroid hormone based on hepatic uptake transporter activity during the perinatal period

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Investigation of interindividual variability in pharmacokinetics of and clinical responses to neuropathic pain medications in cancer patientsPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Prediction of opioid analgesics pharmacokinetics using the biomarkers of drug metabolizing enzyme activity in cancer patients

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Prediction of interindividual variations in pain relief and adverse effects of opioid analgesics based on cancer disease stagePrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

The pharmacoepidemiological study on the adverse reaction of novel therapeutic agent for type 2 diabetes mellitus and the application

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Investigation of interindividual factors determining the pain relief and adverse effects of opioid analgesics in cancer cachexia

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Evaluation of interaction between biotechnology-based drug and chemical drug using medical information databases

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Investigation of interindividual variability in pharmacokinetics of and clinical responses to analgesics for cancer pain reliefPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Investigation of interindividual variability in pharmacokinetics of and clinical responses to opioid analgesics in cancer pain patientsPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

病態時における血液脳関門の破綻と医薬品による中枢神経系副作用の発現との関係解明Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

解熱鎮痛剤によるインフルエンザ脳炎・脳症の重症化に関する機構解明Principal Investigator

Principal Investigator

Project Period (FY)

KAWAKAMI Junichi 川上純一

川上純一カワカミジユンイチ