Takahashi Fumi 高橋富美

… Alternative Names

TAKAHASHI Fumi 高橋富美

YANAGA Fumi

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Researcher Number	50274436
Other IDs
Affiliation (Current)	2022: 産業医科大学, 医学部, 教授
Affiliation (based on the past Project Information) *help	2017 – 2021: 産業医科大学, 医学部, 教授 2016: 九州大学, 医学研究院, 講師 2015: 九州大学, 大学院医学研究院, 講師 2011 – 2015: 九州大学, 医学(系)研究科(研究院), 講師 2014: 九州大学, 医学研究院, 講師 … More 2013: 九州大学, 大学院医学研究院, 助教 2012: 九州大学, 医学(系)研究院(研究科), 講師 2012: 九州大学, 大学院・医学研究院, 教授 2011 – 2012: 九州大学, 医学研究院, 講師 2009 – 2011: Kyushu University, 医学研究院, 助教 2008 – 2010: 九州大学, 大学院・医学研究院, 助教 2000 – 2005: 九州大学, 大学院・医学研究院, 助手 1995 – 1997: 九州大学, 医学部, 助手 Less
Review Section/Research Field	Principal Investigator General pharmacology / General pharmacology / Basic Section 48030:Pharmacology-related Except Principal Investigator Applied pharmacology / Surgical dentistry / General pharmacology / Conservative dentistry / Biological Sciences / Urology / 神経・脳内生理学 / General pharmacology / Basic Section 57030:Conservative dentistry-related
Keywords	Principal Investigator 抗腫瘍薬 / G1期特異的 / サイクリンD1 / Wntシグナル伝達系 / GSK-3 / トロポニン / 心筋肥大症 / 分子生物学 / 遺伝子疾患 / myofbroblast … More / アポトーシス / 創傷治癒 / アクチン / カスパーゼ / myofibroblast / Wntシグナル伝達経路 / モデル動物 / 新規抗腫瘍薬 / 経口抗腫瘍薬 / ＧＳＫ－３活性化 / Wnt / サイクリンＤ１ / 橋渡し研究 / 増殖抑制 / がん / 細胞周期 / 細胞周期拘束 / antiproliferation / cancer / cyclin D1 / cell cycle / 抗がん薬 / 細胞内シグナル調節 / 分子標的薬 / YAP / 心筋梗塞 / 線維化 / 筋線維芽細胞 … More Except Principal Investigator がん / 骨再生 / 増殖抑制 / 細胞周期 / サイクリンD1 / 遺伝子多型 / トロポニン / 分化 / スフィンゴシン-1-リン酸 / 骨芽細胞 / S1P / 硝酸薬 / ニトログリセリン / 二硝酸イソソルビド / 狭心症 / 血管拡張 / 2型アルデヒド脱水素酵素 / ゲノム薬理学 / 薬理遺伝学 / 硝酸イソソルビド / 高気圧酸素負荷 / 平滑筋 / 排尿機能 / 低活動膀胱 / 膀胱排尿筋 / 排尿筋 / 筋収縮機構 / 膀胱平滑筋 / トロポニンT / 新規抗炎症薬 / mPGES-1 / 抗炎症薬 / 炎症 / チアジド / 利尿薬 / 尿酸 / MRP4 / ABCC4 / BCRP / ABCG2 / 薬理ゲノム学 / 薬物トランスポーター / 高血圧 / 副作用 / ファーマコゲノミクス / トランスポーター / 歯科インプラント / Wnt/β-catenin 経路 / Wnt/β-カテニン経路 / インプラント / 骨 / 未分化間葉系幹細胞 / 骨組織 / Wnt5a / 脂質メディエーター / 間葉系幹細胞分化制御 / 脂肪細胞 / 筋収縮 / Ca感受性 / アシドーシス / pH感受性 / muscle contraction / Ca-sensitivity / acidosis / troponin / pH-sensitivity / antiproliferation / cancer / cyclin D1 / cell cycle / 拡張型心筋症 / GSK3β / 心臓リモデリング / 心臓収縮機能 / 生命予後 / 心不全 / ノックアウトマウス / ノックインマウス / 心肥大抑制 / セレコキシブ / ジメチルセレコキシブ / ラット歯根尖切除モデル / 骨誘導能 / 歯根膜幹細胞 / スフェロイド / 血管形成マーカー因子 / 骨芽細胞分化マーカー因子 / 骨形成 / 再生歯内療法 / 歯乳頭由来幹細胞 / S1Pシグナル / 歯髄血管再生療法 Less

GSK-3活性化作用に基づいた心臓線維化抑制薬開発に向けた基盤研究Principal Investigator
- Principal Investigator
  
  高橋富美
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 48030:Pharmacology-related
- Research Institution
  University of Occupational and Environmental Health, Japan
S1Pによる歯乳頭由来幹細胞の象牙芽細胞分化誘導と歯髄血管再生療法への応用
- Principal Investigator
  
  松崎英津子
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 57030:Conservative dentistry-related
- Research Institution
  Fukuoka Dental College
Identification of the tareget molecule for GSK-3 activator DIF towards clinical usagePrincipal Investigator
- Principal Investigator
  
  Takahashi Fumi
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  General pharmacology
- Research Institution
  University of Occupational and Environmental Health, Japan
Function of S1P signaling pathway in bone formation and angiogenesis and its aplication of hard tissue regeneration
- Principal Investigator
  
  Matsuzaki Etsuko
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Conservative dentistry
- Research Institution
  Fukuoka Dental College
Molecular mechanism of sphingosine-1-phosphate-modulated MSC differentiation for hard tissue regenerative therapy
- Principal Investigator
  
  Matsuzaki Etsuko
- Project Period (FY)
  2014 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Conservative dentistry
- Research Institution
  Fukuoka Dental College
Examination of the in vivo effect of DIF, an inhibitor of G1 phase transition derived from Dictyostelium, as a new anti-cancer drugPrincipal Investigator
- Principal Investigator
  
  Takahashi Fumi
- Project Period (FY)
  2013 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  General pharmacology
- Research Institution
  Kyushu University
A new approach to the bone regeneration -the effect of local lithium administration for facilitating bone regeneration-
- Principal Investigator
  
  Sasaki Masanori
- Project Period (FY)
  2013 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Surgical dentistry
- Research Institution
  Kyushu University
Role of GSK3b-mediated suppression of cardiac hypertrophy in heart failure
- Principal Investigator
  
  Morimoto Sachio
- Project Period (FY)
  2013 – 2015
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  General pharmacology
- Research Institution
  Kyushu University
The relationship between trichlormethiazide-induced hyperuricemia and the genotypes of uric acid transporters
- Principal Investigator
  
  TOSHIYUKI Sasaguri
- Project Period (FY)
  2012 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Applied pharmacology
- Research Institution
  Kyushu University
The basic research for the novel treatment for under active bladder -focusing on the construction of troponin system in smooth muscle-
- Principal Investigator
  
  KAJIOKA Shunichi
- Project Period (FY)
  2011 – 2013
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Urology
- Research Institution
  Kyushu University
Identification of an inhibitor of mPGES-1 expression and its target molecule
- Principal Investigator
  
  SASAGURI Toshiyuki
- Project Period (FY)
  2011 – 2012
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  General pharmacology
- Research Institution
  Kyushu University
Approach to the elucidation of bone regeneration mechanism -the effect of hyperbaric oxygen environment on bone metabolism
- Principal Investigator
  
  SASAKI Masanori
- Project Period (FY)
  2010 – 2012
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Surgical dentistry
- Research Institution
  Kyushu University
Examination of the effect of DIF, an inhibitor of G1 phase transition derived from Dictyostelium, as a new anti-cancer drug.Principal Investigator
- Principal Investigator
  
  TAKAHASHI Fumi
- Project Period (FY)
  2009 – 2011
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  General pharmacology
- Research Institution
  Kyushu University
Pharmacogenetic studies on the influence of ALDH2 gene polymorphisms on the vasodilation induced by organic nitrates
- Principal Investigator
  
  SASAGURI Toshiyuki
- Project Period (FY)
  2008 – 2010
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Applied pharmacology
- Research Institution
  Kyushu University
Studies on the signal transduction pathway of differentiation inducing factor to induce cyclin D1 degradationPrincipal Investigator
- Principal Investigator
  
  TAKAHASHI Fumi
- Project Period (FY)
  2004 – 2005
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  General pharmacology
- Research Institution
  KYUSHU UNIVERSITY
微生物由来細胞分化誘導因子の作用機構解明とG_1早期選択的抗腫瘍薬開発への応用
- Principal Investigator
  
  SASAGURI Toshiyuki
- Project Period (FY)
  2002
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Kyushu University
Studies on the signal transduction of difrentiation inducing factor and an application for the development of anti-cancer drug for early G_1 phase.
- Principal Investigator
  
  SASAGURI Toshiyuki
- Project Period (FY)
  2002 – 2004
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  General pharmacology
- Research Institution
  Kyushu University
創傷治癒の過程におけるmyofibroblastの動態を生理活性物質の果たす役割Principal Investigator
- Principal Investigator
  
  高橋富美
- Project Period (FY)
  2000 – 2001
- Research Category
  
  Grant-in-Aid for Encouragement of Young Scientists (A)
- Research Field
  
  General pharmacology
- Research Institution
  Kyushu University
トロポニンTミューテーションの心筋収縮に及ぼす影響Principal Investigator
- Principal Investigator
  
  弥永富美
- Project Period (FY)
  1996
- Research Category
  
  Grant-in-Aid for Encouragement of Young Scientists (A)
- Research Field
  
  General pharmacology
- Research Institution
  Kyushu University
Molecular mechanisms of change in Ca^<2+>-sensitivity of muscle contraction induced by pH-reduction
- Principal Investigator
  
  OHTSUKI Iwao
- Project Period (FY)
  1995 – 1997
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  神経・脳内生理学
- Research Institution
  Kyushu University

[Journal Article] 2,5-Dimethylcelecoxib attenuates cardiac fibrosis caused by cryoinjury-induced myocardial infarction by suppressing the fibroblast-to-myofibroblast transformation via inhibition of the TGF-β signaling pathway2022
- Author(s)
  Ikushima Eigo、Ishikane Shin、Kishigami Takehiro、Matsunaga Hiroaki、Igawa Kazunobu、Tomooka Katsuhiko、Nishimura Yosuke、Takahashi-Yanaga Fumi
- Journal Title
  
  Biochemical Pharmacology
  
  Volume: 197 Pages: 114950-114950
- DOI
  10.1016/j.bcp.2022.114950
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20K07303
[Journal Article] Cardiac and renal protective effects of 2,5-dimethylcelecoxib in angiotensin II and high-salt-induced hypertension model mice2021
- Author(s)
  Yamamoto Misaki、Takahashi-Yanaga Fumi、Arioka Masaki、Igawa Kazunobu、Tomooka Katsuhiko、Yamaura Ken、Sasaguri Toshiyuki
- Journal Title
  
  Journal of Hypertension
  
  Volume: Publish Ahead of Print
- DOI
  10.1097/hjh.0000000000002728
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20K07303
[Journal Article] Glycogen synthase kinase-3 inhibitor as a multi-targeting anti-rheumatoid drug2019
- Author(s)
  M. Arioka and F Takahashi-Yanaga
- Journal Title
  
  Biochemical Pharmacology
  
  Volume: 印刷中 Pages: 207-213
- DOI
  10.1016/j.bcp.2019.02.020
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K08598
[Journal Article] 2,5-Dimethylcelecoxib prevents isoprenaline-induced cardiomyocyte hypertrophy and cardiac fibroblast activation by inhibiting Akt-mediated GSK-3 phosphorylation2019
- Author(s)
  Morishige S, Takahashi-Yanaga F, Ishikane S, Arioka M, Igawa K, Kuroo A, Tomooka K, Shiose A, Sasaguri T.
- Journal Title
  
  Biochemical Pharmacology
  
  Volume: 168 Pages: 82-90
- DOI
  10.1016/j.bcp.2019.06.018
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K06907, KAKENHI-PROJECT-17K08598
[Journal Article] Differentiation‐inducing factor‐1 suppresses cyclin D1‐induced cell proliferation of MCF‐7 breast cancer cells by inhibiting S6K‐mediated signal transducer and activator of transcription 3 synthesis2019
- Author(s)
  Tetsuo Fumi、Arioka Masaki、Miura Koichi、Kai Misato、Kubo Momoko、Igawa Kazunobu、Tomooka Katsuhiko、Takahashi‐Yanaga Fumi、Nishimura Fusanori、Sasaguri Toshiyuki
- Journal Title
  
  Cancer Science
  
  Volume: 110 Pages: 3761-3772
- DOI
  10.1111/cas.14204
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K08598
[Journal Article] Anti-tumor effects of differentiation-inducing factor-1 in malignant melanoma: GSK-3-mediated inhibition of cell proliferation and GSK-3-independent suppression of cell migration and invasion.2017
- Author(s)
  Arioka M, Takahashi-Yanaga F, Kubo M, Igawa K, Sasaguri T.
- Journal Title
  
  Biochem Pharmacol.
  
  Volume: 138 Pages: 31-48
- DOI
  10.1016/j.bcp.2017.05.004
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K08598, KAKENHI-PROJECT-17K15581
[Journal Article] Sphingosine-1-phosphate-enhanced Wnt5a promotes osteogenic differentiation in C3H10T1/2 cells.2016
- Author(s)
  Hashimoto, Y,. Kobayashi, M., Matsuzaki, E., Higashi, K., Takahashi-Yanaga, F., Takano, A., Hirata, M. and Nishimura, F.
- Journal Title
  
  Cell Biol Int
  
  Volume: 40 Pages: 1129-1136
- DOI
  10.1002/cbin.10652
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-24229009, KAKENHI-PROJECT-26462886, KAKENHI-PROJECT-26670824
[Journal Article] GSK-3β heterozygous knockout is cardioprotective in a knockin mouse model of familial dilated cardiomyopathy2016
- Author(s)
  Rasha Mohamed · Sachio Morimoto · Islam Ibrahim · Dong-Yun Zhan · Cheng-Kun Du · Masaki Arioka · Tatsuya Yoshihara · Fumi Takahashi-Yanaga · Toshiyuki Sasaguri
- Journal Title
  
  American Journal of Physiology Heart and Circulatory Physiology
  
  Volume: in press
- DOI
  10.1152/ajpheart.00771.2015
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25670130, KAKENHI-PROJECT-15F15119, KAKENHI-PROJECT-16K08514
[Journal Article] Sphingosine-1-phosphate/S1PR2-mediated signaling triggers Smad1/5/8 phosphorylation and thereby induces Runx2 expression in osteoblasts.2016
- Author(s)
  Higashi, K., Matsuzaki, E., Hashimoto, Y., Takahashi-Yanaga, F., Takano, A., Anan, H., Hirata, M. and Nishimura, F.
- Journal Title
  
  Bone
  
  Volume: 93 Pages: 1-11
- DOI
  10.1016/j.bone.2016.09.003
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-24229009, KAKENHI-PROJECT-16H07066, KAKENHI-PROJECT-26462886, KAKENHI-PROJECT-26670824
[Journal Article] Stage-dependent benefits and risks of pimobendan in mice with genetic dilated cardiomyopathy and progressive heart failure.2015
- Author(s)
  Nonaka M, Morimoto S, Murayama T, Kurebayashi N, Li L, Wang YY, Arioka M, Yoshihara T, Takahashi-Yanaga F, Sasaguri T.
- Journal Title
  
  Br J Pharmacol.
  
  Volume: 172 Pages: 2369-2382
- DOI
  10.1111/bph.13062
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-25670130, KAKENHI-PROJECT-15K08210
[Journal Article] Sphingosine-1-phosphate inhibits differentiation of C3H10T1/2 cells into adipocyte2015
- Author(s)
  Hashimoto Y, Matsuzaki E, Higashi K, Takahashi-Yanaga F, Takano A, Hirata M, Nishimura F.
- Journal Title
  
  Mol. Cell. Biochem.
  
  Volume: 401(1-2) Pages: 39-47
- DOI
  10.1007/s11010-014-2290-1
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-26462886, KAKENHI-PROJECT-24229009
[Journal Article] Differentiation-inducing factor-3 inhibits intestinal tumor growth in vitro and in vivo2015
- Author(s)
  Kubokura N, Takahashi-Yanaga F, Arioka M, Yoshihara T, Igawa K, Tomooka K, Morimoto S, Nakatsu Y, Tsuzuki T, Nakabeppu Y, Matsumoto T, Kitazono T, Sasaguri T
- Journal Title
  
  J Pharmacol Sci,
  
  Volume: 127 Pages: 446-455
- DOI
  10.1016/j.jphs.2015.03.005
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-22221004, KAKENHI-PROJECT-26340025, KAKENHI-PUBLICLY-15H00897, KAKENHI-PLANNED-24108009, KAKENHI-PROJECT-25241012, KAKENHI-PROJECT-25460334
[Journal Article] Differentiation-inducing factor-3 inhibits intestinal tumor growth in vitro and in vivo2015
- Author(s)
  Kubokura N, Takaha-Yanaga F,Arioka M, Yoshihara T, Igawa K,Tomooka K, Morimoto S, Nakatsu Y, Tsuzuki T, Nakabeppu Y, MatsumotoT, Kitazono T and Sasaguri T
- Journal Title
  
  J. Phramcol. Sci.
  
  Volume: in press
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-25460334
[Journal Article] Acceleration of bone regeneration by local application of lithium: Wnt signal-mediated osteoblastogenesis and Wnt signal-independent suppression of osteoclastogenesis2014
- Author(s)
  Arioka M, Takahashi-Yanaga F, Sasaki M, Yoshihara T, Morimoto S, Hirata M, Mori Y, Sasaguri T.
- Journal Title
  
  Biochem. Pharamacol.
  
  Volume: 90(4) Pages: 397-405
- DOI
  10.1016/j.bcp.2014.06.011
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-25463090, KAKENHI-PROJECT-24229009
[Journal Article] Novel effect of 2-aminoethoxydiphenylborate through inhibition of calcium sensitization induced by Rho kinase activation in human detrusor smooth muscle.2013
- Author(s)
  Shahab N, Kajioka S, Takahashi R, Hayashi M, Nakayama S, Sakamoto K, Takeda M, Masuda N, Naito S.
- Journal Title
  
  European Journal of Pharmacology
  
  Volume: 708(1-3) Pages: 14-20
- DOI
  10.1016/j.ejphar.2013.03.006
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23592371
[Journal Article] Novel effect of 2-aminoethoxydiphenylborate through inhibition of calcium sensitization induced by Rho kinase activation in human detrusor smooth muscle2013
- Author(s)
  Shahab N, Kajioka S, Takahashi R, Hayashi M, Nakayama S, Sakamoto K, Takeda M, Masuda N, Naito S
- Journal Title
  
  Eur J Pharmacol
  
  Volume: 708(1-3) Pages: 14-20
- Data Source
  KAKENHI-PROJECT-23592371
[Journal Article] Acceleration of bone development and regeneration through the Wnt/β-catenin signaling pathway in mice heterozygously deficient for GSK-3β2013
- Author(s)
  Arioka M, Takahashi-Yanaga F, Sasaki M, Yoshihara T, Morimoto S, Takashima A, Mori Y, Sasaguri T.
- Journal Title
  
  Biochemical and Biophysical Research Communications.
  
  Volume: 440(4) Pages: 677-682
- DOI
  10.1016/j.bbrc.2013.09.126
- Peer Reviewed
- Data Source
  KAKENHI-PUBLICLY-24111562, KAKENHI-PROJECT-25463090
[Journal Article] DIF-1 inhibits the Wnt/β-catenin signaling pathway by inhibiting TCF7L2 expression in colon cancer cell lines2012
- Author(s)
  Fan, X., TakahashiYanaga, F., Morimoto, S., Zhan, D.-Y., Igawa, K., Tomooka, K., & Sasaguri, T
- Journal Title
  
  Biochem Pharmacol
  
  Volume: 83(1) Pages: 47-56
- DOI
  10.1016/j.bcp.2011.10.001
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590284, KAKENHI-PROJECT-23659138
[Journal Article] Role of brain serotonin dysfunction in the pathophysiology of congestive heart failure2012
- Author(s)
  Li L, Morimoto S, Take S, Zhan DY, Du CK Wang YY, Fan XL. Yoshihara T, Takahashi-Yanaga F, Katafuchi T, Sasaguri T
- Journal Title
  
  J MoI Cell Cardiol
  
  Volume: 53 Pages: 760-767
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24390140
[Journal Article] Obstruction enhances rho-kinase pathway and diminishes protein kinase C palhway in carbachol-induced calcium sensitization in contraction of α-toxin permeabilized guinea pig detrusor smooth muscle2012
- Author(s)
  Shahab N, et.al.
- Journal Title
  
  Neurourology & Urodynamics
  
  Volume: (in Press) Pages: 593-599
- DOI
  10.1002/nau.21193
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590315, KAKENHI-PROJECT-22590347, KAKENHI-PROJECT-22591793, KAKENHI-PROJECT-23592371
[Journal Article] Endogenous cardiac troponin T modulates Ca(2+)-mediated smooth muscle contraction2012
- Author(s)
  Kajioka S, Takahashi-Yanaga F, Shahab N, Onimaru M, Matsuda M, Takahashi R, Asano H, Morita H, Morimoto S, Yonemitsu Y, Hayashi M, Seki N, Sasaguri T, Hirata M, Nakayama S, Naito S
- Journal Title
  
  Sci Rep
  
  Volume: 2 Pages: 979-979
- Data Source
  KAKENHI-PROJECT-23592371
[Journal Article] Obstruction enhances rho-kinase pathway and diminishes protein kinase C pathway in carbachol-induced calcium sensitization in contraction ofα-toxin permeabilized guinea pig detrusor smooth muscle2012
- Author(s)
  Shahab N, Kajioka S, Takahashi-Yanaga F, Onimaru M, Matsuda M, Seki N, Naito S
- Journal Title
  
  Neurourol Urodyn
  
  Volume: 31(4) Pages: 593-599
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23592371
[Journal Article] Differential effects of organic nitrates on arterial diameter among healthy Japanese participants with different mitochondrial aldehyde dehydrogenase 2 genotypes : randomised crossover trial.2011
- Author(s)
  Sakata S, Yoshihara T, Arima H, Shiraishi F, Oniki H, Takahashi-Yanaga F, Matsumura K, Sasaguri T.
- Journal Title
  
  BMJ Open in press.
- Data Source
  KAKENHI-PROJECT-20390160
[Journal Article] Celecoxib and 2,5-dimethyl-celecoxib prevent cardiac remodeling inhibiting Akt-mediated signal transduction in an inherited DCM mouse model2011
- Author(s)
  Fan, X., Takahashi-Yanaga, F., Morimoto, S., Zhan, D.-Y., Igawa, K., Tomooka, K., & Sasaguri, T
- Journal Title
  
  J Pharmacol Exp Ther
  
  Volume: 338(1) Pages: 2-11
- DOI
  10.1124/jpet.111.179325
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590284, KAKENHI-PROJECT-23300145
[Journal Article] Targeting Wnt signaling : can we safely eradicate cancer stem cells?2010
- Author(s)
  Takahashi-Yanaga F, Kahn M.
- Journal Title
  
  Clin Cancer Res.
  
  Volume: 16(12) Pages: 3153-62
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590284
[Journal Article] Anti-angiogenic effectdifferentiation-inducing factorinvolving VEGFR-2 expression inhibition independent of the Wnt/beta-catenin signaling pathway2010
- Author(s)
  Yoshihara, T., Takahashi-Yanaga, F., Shiraishi, F., Morimoto, S., Watanabe, Y., Hirata, M., Hoka, S., & SasaguriT
- Journal Title
  
  Mol. Cancer
  
  Volume: 9(1) Pages: 245-245
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590284
[Journal Article] Targeting Wnt Signaling : Can We Safely Eradicate Cancer Stem Cells? Crin2010
- Author(s)
  Takahashi-Yanaga, F. & Kahn, M
- Journal Title
  
  Cancer Res
  
  Volume: 16(12) Pages: 3153-3162
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590284
[Journal Article] Dictyostelium differentiation-inducing factor-l binds to mitochondrial ma late dehydrogenase and inhibits its activity2010
- Author(s)
  Matsuda, T., Takahashi-Yanaga, F., Yoshihara, T., Maenaka, K., Watanabe, Y., Miwa, Y., Morimoto, S., Kubohara, Y., Hirata, M., & Sasaguri, T
- Journal Title
  
  J. Pharmacol. Sci
  
  Volume: 112(3) Pages: 320-326
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590284
[Journal Article] Dictyostelium differentiation-inducing factor-1 binds to mitochondrial malate dehydrogenase and inhibits its activity2010
- Author(s)
  Matsuda, T., Takahashi-Yanaga, F., Yoshihara, T., Maenaka, K., Watanabe, Y., Miwa, Y., Morimoto, S., Kubohara, Y., Hirata, M., Sasaguri, T.
- Journal Title
  
  J Pharmacol Sci. 112
  
  Pages: 320-326
- NAID
  10027744481
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590284
[Journal Article] Anti-angiogenic effects of differentiation-inducing factor-1 involving VEGFR-2expression inhibition independent of the Wnt/ss-catenin signaling pathway.2010
- Author(s)
  Yoshihara T, Takahashi-Yanaga F, Shiraishi F, Morimoto S, Watanabe Y, Hirata M, Hoka S, Sasaguri T.
- Journal Title
  
  Mol Cancer.
  
  Volume: 9 Pages: 245-245
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590284
[Journal Article] Glycogen synthase kinase-3β is tyrosine-phosphorylated by MEK1 in human skin fibroblasts.2004
- Author(s)
  Fumi Takahashi-Yanaga et al.
- Journal Title
  
  Biochem.Biophys.Res.Commun. 316
  
  Pages: 411-415
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-14370034
[Journal Article] Dictyostelium differentiation-inducing factor-3 activates glycogen synthase kinase-3β and degrades cyclin D1 in mammalian cells.2003
- Author(s)
  Fumi Takahashi-Yanaga et al.
- Journal Title
  
  J.Biol.Chem. 278
  
  Pages: 9663-9670
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-14370034
[Journal Article] Dictyostelium differentiation-inducing factor-3 activates glycogen synthase kinase-3β and degrades cyclin D1 in mammalian cells.2003
- Author(s)
  Fumi Takahashi-Yanaga et al.
- Journal Title
  
  J.Biol.Chem. 278(11)
  
  Pages: 9663-9670
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14370034
[Journal Article] Celecoxib and 2,5-dimethyl-celecoxib prevent cardiac remodeling inhibiting Akt-mediated signal transduction in an inherited DCM mouse model
- Author(s)
  Fan X, Takahashi-Yanaga F, Morimoto S, Zhan D.-Y, Igawa K, Tomooka K, Sasaguri T.
- Journal Title
  
  Journal of Pharmacology and Experimental Therapeutics
  
  Volume: 印刷中
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590284
[Presentation] 2,5-Dimethylcelecoxib attenuates cardiac fibrosis caused by cryoinjury-induced myocardial infarction by suppressing the fibroblast-to-myofibroblast transformation via inhibition of the TGF-β signaling pathway2022
- Author(s)
  幾島　栄悟、石兼　真、瀧口　知浩、岸上　赳大、松永　洋明、豊平　由美子、西村　陽介、高橋　富美
- Organizer
  第95回　日本薬理学会年会
- Data Source
  KAKENHI-PROJECT-20K07303
[Presentation] Cardiac and renal protective effects of 2,5-dimethylcelecoxib in angiotensin II-induced hypertension model mice2021
- Author(s)
  山本美佐紀, 高橋富美, 笹栗俊之
- Organizer
  第94回日本薬理学会年会
- Data Source
  KAKENHI-PROJECT-20K07303
[Presentation] 2,5-Dimethylcelecoxib attenuates cardiac remodeling after cryoinjury-induced myocardial infarction by suppressing the fibroblast-myofibroblast transformation2021
- Author(s)
  幾島栄悟, 石兼真, 岸上赳大, 松永洋明, 瀧口知浩, 豊平由美子, 高橋富美
- Organizer
  第94回日本薬理学会年会
- Data Source
  KAKENHI-PROJECT-20K07303
[Presentation] Differentiation-inducing factor-1 suppresses breast cancer cell proliferation by reducing STAT3-mediated cyclin D1 expression2020
- Author(s)
  哲翁ふみ, 有岡将基, 高橋富美, 西村英紀, 笹栗俊之
- Organizer
  第93回日本薬理学会年会
- Data Source
  KAKENHI-PROJECT-17K08598
[Presentation] 心筋梗塞後心臓リモデリングにおける筋線維芽細胞形質転換に対するジメチルセレコキシブの作用の検討2020
- Author(s)
  幾島栄悟，石兼真，岸上赳大，松永洋明，瀧口知浩，豊平由美子，高橋富美
- Organizer
  第73回日本薬理学会西南部会
- Data Source
  KAKENHI-PROJECT-20K07303
[Presentation] S1P/S1PR2 signaling pathway promotes bone formation on rat apicoectomy model2020
- Author(s)
  Etsuko Matsuzaki, Noriyoshi Matsumoto, Masahiko Minakami, Ryo Matsuyuki, Kazuma Matsumoto, Junko Hatakeyama, Fumi Takahashi-Yanaga, Hisashi Anan
- Organizer
  第93回日本薬理学会年会
- Data Source
  KAKENHI-PROJECT-17K11729
[Presentation] Differentiation-inducing factor-1によるトリプルネガティブ乳癌の抑制機序2019
- Author(s)
  哲翁ふみ, 有岡将基, 高橋富美, 西村英紀, 笹栗俊之
- Organizer
  第72回日本薬理学会西南部会
- Data Source
  KAKENHI-PROJECT-17K08598
[Presentation] S1PR2作動薬による骨再生メカニズムの解明2019
- Author(s)
  松﨑英津子、松本典祥、水上正彦、畠山純子、松雪　稜、高橋富美、平田雅人、阿南　壽
- Organizer
  第40回日本臨床薬理学会学術総会
- Data Source
  KAKENHI-PROJECT-17K11729
[Presentation] Differentiation-Inducing Factor はYAPを介してHippoシグナル伝達経路に影響を及ぼす2019
- Author(s)
  高橋　富美，石兼　真、豊平　由美子
- Organizer
  第92回　日本薬理学会年会
- Data Source
  KAKENHI-PROJECT-17K08598
[Presentation] マウス脛骨骨組織においてS1PRシグナル伝達経路が骨形成および骨芽細胞分化マーカーに及ぼす影響2018
- Author(s)
  松崎英津子、高橋富美、平田雅人、阿南　壽
- Organizer
  第71回日本薬理学会西南部会
- Data Source
  KAKENHI-PROJECT-17K11729
[Presentation] マウス脛骨骨組織においてS1PR2シグナル伝達経路が骨芽細胞分化マーカーに及ぼす影響2017
- Author(s)
  松崎英津子、東　克匡、橋本陽子、高橋富美、阿南　壽
- Organizer
  第38回日本臨床薬理学会学術総会
- Data Source
  KAKENHI-PROJECT-17K11729
[Presentation] Anti-tumor effect of DIF-1 in malignant melanoma2017
- Author(s)
  高橋　富美、有岡　将基、久保　桃子、笹栗　俊之
- Organizer
  第７６回日本癌学会
- Data Source
  KAKENHI-PROJECT-17K08598
[Presentation] DIF-1 inhibits proliferation, infiltration and metastasis of malignant melanoma through GSK-3 activation2016
- Author(s)
  有岡将基、高橋富美、笹栗俊之
- Organizer
  第89回日本薬理学会年会
- Place of Presentation
  横浜
- Year and Date
  2016-03-09
- Data Source
  KAKENHI-PROJECT-25460334
[Presentation] GSK3βヘテロノックアウトは家族性拡張型心筋症モデルマウスにおいて心臓保護的に働く（口演）2016
- Author(s)
  Mohamed R、森本幸生、Ibrahim I、有岡将基、吉原達也、高橋富美、笹栗俊之
- Organizer
  第89回日本薬理学会年会
- Place of Presentation
  横浜
- Year and Date
  2016-03-09
- Data Source
  KAKENHI-PROJECT-25670130
[Presentation] GSK3β heterozygous knockout is cardioprotective in familial dilated cardiomyopathy mouse model（口演）2015
- Author(s)
  Mohamed R, Morimoto S, Ibrahim I, Arioka M, Yoshihara T, Takahashi-Yanaga F, Sasaguri T.
- Organizer
  第68回日本薬理学会西南部会
- Place of Presentation
  下関
- Year and Date
  2015-11-22
- Data Source
  KAKENHI-PROJECT-25670130
[Presentation] DIF-1による悪性黒色腫の増殖・浸潤・転移の抑制2015
- Author(s)
  有岡将基、高橋富美、笹栗俊之
- Organizer
  第68回日本薬理学会西南部会
- Place of Presentation
  下関
- Year and Date
  2015-11-21
- Data Source
  KAKENHI-PROJECT-25460334
[Presentation] DIF-1はGSK-3βの活性化を介して悪性黒色腫に抗腫瘍効果をもたらす2015
- Author(s)
  有岡将基、高橋富美、笹栗俊之
- Organizer
  第36回日本臨床薬理学会学術総会
- Place of Presentation
  東京
- Year and Date
  2015-12-09
- Data Source
  KAKENHI-PROJECT-25460334
[Presentation] DIF-1 exerts antitumor activity by suppressing the Wnt/β- catenin signaling pathway in melanoma cell line B16BL62015
- Author(s)
  有岡将基、高橋富美、笹栗俊之
- Organizer
  第74回日本癌学会学術総会
- Place of Presentation
  名古屋
- Year and Date
  2015-10-08
- Data Source
  KAKENHI-PROJECT-25460334
[Presentation] 歯科インプラント埋入のための抜歯窩治癒過程の経過観察-炭酸リチウム局所投与の効果評価のためのベースライン調査-2014
- Author(s)
  有岡将基、高橋富美、佐々木匡理、上妻亜也子、森悦秀、笹栗俊之
- Organizer
  第35回日本臨床薬理学会学術総会
- Place of Presentation
  松山
- Year and Date
  2014-12-05
- Data Source
  KAKENHI-PROJECT-25463090
[Presentation] 心肥大モデルマウス、GSK-3βノックアウトマウスを用いたセレコキシブ・ジメチルセレコキシブの効果2014
- Author(s)
  藤田愛、高橋富美、森本幸生、笹栗俊之
- Organizer
  日本薬理学会年会
- Place of Presentation
  仙台
- Data Source
  KAKENHI-PROJECT-25670130
[Presentation] GSK‐3と創薬　―がん、心不全、骨疾患の新規治療法を探る2014
- Author(s)
  高橋　富美
- Organizer
  第12回口腔医科学フロンティア
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-25460334
[Presentation] Influence of ALDH2 genotype on vascular endothelial function after a long-term treatment with glyceryl trinitrate2014
- Author(s)
  吉原達也、白石富美恵、有馬久富、高橋富美、池松秀之、笹栗俊之
- Organizer
  第87回日本薬理学会年会
- Place of Presentation
  仙台
- Data Source
  KAKENHI-PROJECT-24390140
[Presentation] GSK-3阻害薬の骨再生促進薬としての可能性2013
- Author(s)
  有岡将基,　高橋富美,　佐々木匡理,　笹栗俊之
- Organizer
  第66回日本薬理学会西南部会
- Place of Presentation
  福岡大学薬学部
- Data Source
  KAKENHI-PROJECT-25463090
[Presentation] ヒト膀胱排尿筋のCa感受性の収縮機構の検討2013
- Author(s)
  梶岡俊一、Nouval Shahab、林摩耶、高橋良輔、坂本一志、武田全弘、増田典之、内藤誠二
- Organizer
  第101回日本泌尿器科学会総会
- Place of Presentation
  札幌
- Data Source
  KAKENHI-PROJECT-23592371
[Presentation] ALDH2遺伝子多型がニトログリセリンの単回および長期投与効果に及ぼす影響に関する日本人健康成人を対象としたランダム化クロスオーバー試験2013
- Author(s)
  吉原達也、白石富美恵、有馬久富、高橋富美、池松秀之、笹栗俊之
- Organizer
  第34回日本臨床薬理学会学術総会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-24390140
[Presentation] ヒト膀胱排尿筋のcAMPによるCa感受性収縮機構への弛緩効果の検討2013
- Author(s)
  梶岡俊一、林摩耶、高橋良輔、石上隆雄、武田全弘、増田典之、内藤誠二
- Organizer
  第20回日本日本排尿機能学会
- Place of Presentation
  静岡
- Data Source
  KAKENHI-PROJECT-23592371
[Presentation] ALDH2遺伝子多型がニトログリセリンの単回および長期投与効果に及ぼす影響2013
- Author(s)
  吉原達也、白石富美恵、有馬久富、高橋富美、池松秀之、笹栗俊之
- Organizer
  第23回日本循環薬理学会
- Place of Presentation
  福岡
- Data Source
  KAKENHI-PROJECT-24390140
[Presentation] Inhibition of GSK-3ss accelerates bone formation via the activation of the Wnt/β-catenin signaling pathway <GSK-3β阻害はWnt/ss -catenin シグナル活性化を介して骨形成を促進する>(口演)2013
- Author(s)
  有岡将基、高橋富美、佐々木匡理、笹栗俊之
- Organizer
  第86回日本薬理学会年会
- Place of Presentation
  福岡
- Data Source
  KAKENHI-PROJECT-23659138
[Presentation] 担癌マウスを用いたDifferentiation-Inducing Factor-1の抗腫瘍作用の検討2013
- Author(s)
  高橋　富美、笹栗　俊之
- Organizer
  第34回日本臨床薬理学会学術総会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-25460334
[Presentation] Anti-Tumor Effect of Differentiation-Inducing Factors on a Colon Cancer Cell Line HCT-116 <大腸癌細胞株 HCT-116 に対するDifferentiation-Inducing Factor の抗腫瘍効果>(口演)2013
- Author(s)
  久保倉尚哉、高橋富美、松本主之、笹栗俊之
- Organizer
  第86回日本薬理学会年会
- Place of Presentation
  福岡
- Data Source
  KAKENHI-PROJECT-23659138
[Presentation] ALDH2遺伝子多型がニトログリセリンの単回および長期投与効果に及ぼす影響に関する日本人健康成人を対象としたランダム化クロスオーバー試験2013
- Author(s)
  吉原達也、白石富美恵、有馬久富、高橋富美、池松秀之、笹栗俊之
- Organizer
  第32回臨床薬理阿蘇九重カンファレンス
- Place of Presentation
  松山
- Data Source
  KAKENHI-PROJECT-24390140
[Presentation] ALDH2遺伝子多型がニトログリセリン長期投与効果に及ぼす影響2013
- Author(s)
  吉原達也、白石富美恵、有馬久富、高橋富美、池松秀之、笹栗俊之
- Organizer
  第66回日本薬理学会西南部会
- Place of Presentation
  福岡
- Data Source
  KAKENHI-PROJECT-24390140
[Presentation] 大腸癌細胞に対するDifferentiation-Inducing Factor-3の抗腫瘍効果2013
- Author(s)
  久保倉　尚哉、高橋　富美、笹栗　俊之
- Organizer
  第66回日本薬理学会西南部会
- Place of Presentation
  福岡
- Data Source
  KAKENHI-PROJECT-25460334
[Presentation] Ca^<2+> sensitization without activation of G protein is independent of calmodulin in contraction of human detrusor smooth muscle2013
- Author(s)
  Takahashi R, Kajioka S, Shahab N, Hayashi M, Naito S
- Organizer
  28^<th> Annual EAU Congress 2013
- Place of Presentation
  Milan(Poster presentation)
- Data Source
  KAKENHI-PROJECT-23592371
[Presentation] GSK-3β活性化物質DIF-1の担がんモデルマウスへの経口投与による抗腫瘍効果2013
- Author(s)
  高橋　富美、笹栗　俊之
- Organizer
  第72回日本癌学会学術総会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-25460334
[Presentation] MRP4遺伝子多型がトリクロルメチアジド単回投与後の血清尿酸値および尿酸クリアランスに及ぼす影響:パイロットスタディ2013
- Author(s)
  吉原達也、早水憲吾, 永野晃弘, 有岡将基, 北村悠, 高橋富美, 池松秀之, 有馬久富, 笹栗俊之
- Organizer
  第86回日本薬理学会年会
- Place of Presentation
  福岡
- Data Source
  KAKENHI-PROJECT-24390140
[Presentation] The role of cyclic nucleotides in regulation of pig urethral smooth muscle.2013
- Author(s)
  Kajioka S, Hayashi M, Takahashi R, Naito S
- Organizer
  The 43rd Annual Meeting of International Continence Society
- Place of Presentation
  Barcelona, Spain
- Data Source
  KAKENHI-PROJECT-23592371
[Presentation] Tumor suppression by GSK-3ss activator DIF-1 in colorectal and xenografted cancer model mice <GSK-3ss活性化物質 DIF-1の大腸がんおよび担がんモデルマウスにおける抗腫瘍効果>(ポスター)2013
- Author(s)
  高橋富美、笹栗俊之
- Organizer
  第86回日本薬理学会年会
- Place of Presentation
  福岡
- Data Source
  KAKENHI-PROJECT-23659138
[Presentation] The role of cyclic nucleotides in regulation of pig urethral smooth muscle2013
- Author(s)
  Kajioka S, Hayashi M, Takahashi R, Naito S
- Organizer
  The 43^<rd> Annual Meeting of International Continence Society
- Place of Presentation
  Barcelona(Poster presentation)
- Data Source
  KAKENHI-PROJECT-23592371
[Presentation] Tumor suppression by GSK-3β activator DIF-1 in colorectal and xenografted cancer model mice2013
- Author(s)
  高橋富美
- Organizer
  第86回日本薬理学会年会
- Place of Presentation
  福岡
- Data Source
  KAKENHI-PROJECT-23659138
[Presentation] リチウムの Wnt シグナル活性化作用による新生骨形成の促進(口演)2012
- Author(s)
  有岡将基、高橋富美、佐々木匡理、笹栗俊之
- Organizer
  第31回臨床薬理阿蘇九重カンファレンス
- Place of Presentation
  別府
- Data Source
  KAKENHI-PROJECT-23659138
[Presentation] MRP4遺伝子多型がトリクロルメチアジド単回投与後の血清尿酸値および尿酸クリアランスに及ぼす影響 : パイロットスタディ2012
- Author(s)
  吉原達也, 早水憲吾, 永野晃弘, 有岡将基, 北村悠, 高橋富美, 池松秀之, 有馬久富, 笹栗俊之
- Organizer
  第33回日本臨床薬理学会学術総会
- Place of Presentation
  宜野湾
- Data Source
  KAKENHI-PROJECT-24390140
[Presentation] Differentiation-inducing factor-1 のモデルマウスを用いた抗腫瘍作用の検討(ポスター)2012
- Author(s)
  高橋富美、吉原達也、笹栗俊之
- Organizer
  第33回日本臨床薬理学会学術総会
- Place of Presentation
  宜野湾
- Data Source
  KAKENHI-PROJECT-23659138
[Presentation] Wnt/ss-catenin シグナル活性化によるリチウムの骨形成促進作用(口演)(優秀発表賞受賞)2012
- Author(s)
  有岡将基、高橋富美、佐々木匡理、笹栗俊之
- Organizer
  第65回日本薬理学会西南部会
- Place of Presentation
  熊本
- Year and Date
  2012-11-23
- Data Source
  KAKENHI-PROJECT-23659138
[Presentation] 大腸癌細胞株 HCT-116 に対する differentiation-inducing Factor の抗腫瘍効果(ポスター)2012
- Author(s)
  久保倉尚哉、高橋富美、松本主之、笹栗俊之
- Organizer
  第71回日本癌学会学術総
- Place of Presentation
  札幌
- Data Source
  KAKENHI-PROJECT-23659138
[Presentation] 細胞性粘菌由来分化誘導因子DIF-1はヒト大腸癌由来HCT-116細胞においてc-Mycの発現を低下させる2012
- Author(s)
  神宮司健太郎、高橋富美、中村俊央、笹栗俊之
- Organizer
  第85回日本薬理学会学術総会
- Place of Presentation
  京都
- Year and Date
  2012-03-14
- Data Source
  KAKENHI-PROJECT-21590284
[Presentation] The effect of cyclic nucleotides on Ca sensitization induced by muscarinic stimulation in pig detrusor smooth muscle2012
- Author(s)
  Kajioka S, Shahab N, Takahashi R, Seki N, Naito S
- Organizer
  The 27^<th> Annual EAU Congress
- Place of Presentation
  Paris France
- Data Source
  KAKENHI-PROJECT-23592371
[Presentation] The inhibition of DUSP-1 expressionenhancesanti-tumor effects of differentiation-inducing factor-1 inHeLa eel 1s<DUSP-1発現抑制にdifferentiation-inducingfactor-1抗腫瘍活性の増強効果〉2012
- Author(s)
  吉原達也、高橋富美、笹栗俊之
- Organizer
  第85回日本薬理学会学術総会
- Place of Presentation
  京都
- Year and Date
  2012-03-15
- Data Source
  KAKENHI-PROJECT-21590284
[Presentation] Differentiation-inducing factor-1のモデルマウスを用いた抗腫瘍作用の検討2012
- Author(s)
  高橋富美
- Organizer
  第33回日本臨床薬理学会学術総会
- Place of Presentation
  宜野湾
- Data Source
  KAKENHI-PROJECT-23659138
[Presentation] The inhibition of DUSP-1 expression enhances anti-tumor effects of differentiation-inducing factor-1 in HeLa cells<DUSP-1 発現抑制によるdifferentiation-inducing factor-1 の抗腫瘍活性の増強効果>2012
- Author(s)
  吉原達也、高橋富美、笹栗俊之
- Organizer
  第85回日本薬理学会学術総会
- Place of Presentation
  京都
- Year and Date
  2012-03-15
- Data Source
  KAKENHI-PROJECT-23659138
[Presentation] Wntシグナル阻害剤DIF-1の経口投与による抗腫瘍効果2012
- Author(s)
  高橋富美
- Organizer
  第71回日本癌学会学術総会
- Place of Presentation
  札幌
- Data Source
  KAKENHI-PROJECT-23659138
[Presentation] ヒト膀胱排尿平滑筋のトロポニンサブユニットの分子生物学的包括的検討2012
- Author(s)
  梶岡俊一,Nouval Shahab,高橋良輔,内藤誠二
- Organizer
  第19回排尿機能学会
- Place of Presentation
  名古屋
- Data Source
  KAKENHI-PROJECT-23592371
[Presentation] Wnt シグナル阻害剤 DIF-1 の経口投与による抗腫瘍効果(ポスター)2012
- Author(s)
  高橋富美、笹栗俊之
- Organizer
  第71回日本癌学会学術総
- Place of Presentation
  札幌
- Data Source
  KAKENHI-PROJECT-23659138
[Presentation] The effect of cyclic nucleotides on carbachol-induced calcium sensitization in contraction of alpha-toxin permeabilized human and pig detrusor smooth muscle2012
- Author(s)
  Kajioka S, Shahab N, Hayashi M, Takahashi R, Seki N, Naito S
- Organizer
  The 32^<nd> Congress of Societe internationale d'Urologie
- Place of Presentation
  Fukuoka Japan
- Data Source
  KAKENHI-PROJECT-23592371
[Presentation] Rho-kinase pathway diminishes the relaxation effect of cyclic adenosine monophosphate on carbachol-induced calcium sensitization in contraction of a-toxin permeabilized Human detrusor smooth muscle2012
- Author(s)
  Kajioka S, Shahab N, Hayashi M, Takahashi R, Seki N, Naito S
- Organizer
  AUA Annual Meeting
- Place of Presentation
  Atlanta USA
- Data Source
  KAKENHI-PROJECT-23592371
[Presentation] セレコキシブによる Wnt シグナル伝達経路阻害を介した骨芽細胞の分化抑制(ポスター)2012
- Author(s)
  永野晃弘、高橋富美、笹栗俊之
- Organizer
  第33回日本臨床薬理学会学術総会
- Place of Presentation
  宜野湾
- Data Source
  KAKENHI-PROJECT-23659138
[Presentation] 細胞性粘菌由来分化誘導因子 DIF-1 はヒト大腸癌由来 HCT-116 細胞においてc-Myc の発現を低下させる2012
- Author(s)
  神宮司健太郎、高橋富美、中村俊央、笹栗俊之
- Organizer
  第85回日本薬理学会学術総会
- Place of Presentation
  京都
- Year and Date
  2012-03-14
- Data Source
  KAKENHI-PROJECT-23659138
[Presentation] 細胞性粘菌由来分化誘導因子DIF-1ははト大腸癌由来HCT-116細胞においてc-Mycの発現を低下させる2012
- Author(s)
  神宮司健太郎、高橋富美、中村俊央、笹栗俊之
- Organizer
  第85回日本薬理学会学術総会
- Place of Presentation
  京都
- Year and Date
  2012-03-14
- Data Source
  KAKENHI-PROJECT-21590284
[Presentation] DUSP-1の抑制によりdifferentiation-inducing factor-1の抗腫瘍効果は増強する2012
- Author(s)
  吉原達也、高橋富美、笹栗俊之
- Organizer
  第85回日本薬理学会学術総会
- Place of Presentation
  京都
- Year and Date
  2012-03-15
- Data Source
  KAKENHI-PROJECT-21590284
[Presentation] Wnt シグナル阻害剤Differentiation-inducing factor-1 の抗腫瘍活性の検討2011
- Author(s)
  高橋富美、吉原達也、笹栗俊之
- Organizer
  第70回日本癌学会学術総会
- Place of Presentation
  名古屋
- Year and Date
  2011-10-03
- Data Source
  KAKENHI-PROJECT-23659138
[Presentation] DUSP-1の抑制によりdifferentiation-inducingfactor-1の抗腫瘍効果は増強する2011
- Author(s)
  吉原達也、高橋富美、笹栗俊之
- Organizer
  第32回日本臨床薬理学会年会
- Place of Presentation
  浜松
- Year and Date
  2011-12-02
- Data Source
  KAKENHI-PROJECT-21590284
[Presentation] DUSP-1の抑制によりdifferentiation-inducingfactor-1の抗腫瘍効果は増強する2011
- Author(s)
  吉原達也、高橋富美、笹栗俊之
- Organizer
  第70回日本癌学会学術総会
- Place of Presentation
  名古屋
- Year and Date
  2011-10-03
- Data Source
  KAKENHI-PROJECT-21590284
[Presentation] Differentiation-inducing factor-1 inhibits the Wnt signaling pathway by reducing TCF7L2 expression in colon cancer cells2011
- Author(s)
  Jingushi, K., Takahashi, F., Sasaguri, T.
- Organizer
  第70回日本癌学会学術総会
- Place of Presentation
  名古屋
- Year and Date
  2011-10-04
- Data Source
  KAKENHI-PROJECT-21590284
[Presentation] Differentiation-inducing factor-1 inhibits the Wnt signaling pathway by reducing TCF7L2 expression in colon cancer cells2011
- Author(s)
  Jingushi, K., Takahashi, F., Sasaguri, T
- Organizer
  第70回日本癌学会学術総会
- Place of Presentation
  名古屋
- Year and Date
  2011-10-04
- Data Source
  KAKENHI-PROJECT-23659138
[Presentation] DUSP-1の抑制によりdifferentiation-inducing factor-1の抗腫瘍効果は増強する2011
- Author(s)
  吉原達也、高橋富美、笹栗俊之
- Organizer
  第32回日本臨床薬理学会年会(12/1-3:浜松)
- Place of Presentation
  浜松
- Year and Date
  2011-12-02
- Data Source
  KAKENHI-PROJECT-21590284
[Presentation] DUSP-1 の抑制によりdifferentiation-inducing factor-1 の抗腫瘍効果は増強する2011
- Author(s)
  吉原達也、高橋富美、笹栗俊之
- Organizer
  第70回日本癌学会学術総会
- Place of Presentation
  名古屋
- Year and Date
  2011-10-03
- Data Source
  KAKENHI-PROJECT-23659138
[Presentation] DUSP-1の抑制によりdifferentiation-inducing factor-1の抗腫瘍効果は増強する2011
- Author(s)
  吉原達也、高橋富美、笹栗俊之
- Organizer
  第70回日本癌学会学術総会
- Place of Presentation
  名古屋
- Year and Date
  2011-10-03
- Data Source
  KAKENHI-PROJECT-21590284
[Presentation] DUSP-1 の抑制によりdifferentiation-inducing factor-1 の抗腫瘍効果は増強する2011
- Author(s)
  吉原達也、高橋富美、笹栗俊之
- Organizer
  第32回日本臨床薬理学会年会
- Place of Presentation
  浜松
- Year and Date
  2011-12-02
- Data Source
  KAKENHI-PROJECT-23659138
[Presentation] 細胞性粘菌由来分化誘導因子DIFによるmPGES-1の発現抑制機序の解明2011
- Author(s)
  高橋富美、笹栗俊之
- Organizer
  第32回日本臨床薬理学会年会
- Place of Presentation
  浜松
- Data Source
  KAKENHI-PROJECT-23659138
[Presentation] Differentiation-inducingfactor-1inhibitstheWntsignalingpathwaybyreducingTCF7L2expressionincoloncancercells2011
- Author(s)
  Jingushi, K., Takahashi, F., SasaguriT
- Organizer
  第70回日本癌学会学術総会
- Place of Presentation
  名古屋
- Year and Date
  2011-10-04
- Data Source
  KAKENHI-PROJECT-21590284
[Presentation] Wntシグナル阻害剤Differentiation-inducing factor-1の抗腫瘍活性の検討2011
- Author(s)
  高橋富美、吉原達也、笹栗俊之
- Organizer
  第70回日本癌学会学術総会
- Place of Presentation
  名古屋
- Year and Date
  2011-10-03
- Data Source
  KAKENHI-PROJECT-21590284
[Presentation] Wntシグナル阻害剤Differentiation-inducingfactor-1の抗腫瘍活性の検討2011
- Author(s)
  高橋富美、吉原達也、笹栗俊之
- Organizer
  第70回日本癌学会学術総会
- Place of Presentation
  名古屋
- Year and Date
  2011-10-03
- Data Source
  KAKENHI-PROJECT-21590284
[Presentation] Influence of aldehyde dehydrogenase-2 gene polymorphism on vasodilatation induced by organic nitrates in healthy human subjects.2010
- Author(s)
  Sakata S, Ichijima K, Oniki H, Miwa Y, Arima H, Matsumura K, Yoshihara T, Takahashi-Yanaga F, Shiraishi F, Sasaguri T
- Organizer
  WorldPharma 2010
- Place of Presentation
  コペンハーゲン
- Data Source
  KAKENHI-PROJECT-20390160
[Presentation] 酸化ストレス誘発小腸腫瘍に対するDifferentiation-inducing factor-1の抗腫瘍効果2010
- Author(s)
  高橋富美、吉原達也、中津可道、續輝久、中別府雄作、笹栗俊之
- Organizer
  第69回日本癌学会学術総会
- Place of Presentation
  大阪
- Year and Date
  2010-09-22
- Data Source
  KAKENHI-PROJECT-21590284
[Presentation] 2型アルデヒド脱水素酵素の遺伝子多型ガニトログリセリンおとび二硝酸イソソルビドの血管拡張作用に印ぼす効果2010
- Author(s)
  吉原達也, 坂田智子, 白石富美恵, 鬼木秀幸, 市島久仁彦, 大坪俊夫, 三輪宜一, 高橋富美, 有馬久富, 松村潔, 笹栗俊之
- Organizer
  第31回日本臨床薬理学会年会
- Place of Presentation
  京都
- Data Source
  KAKENHI-PROJECT-20390160
[Presentation] Effect of aldehyde dehydrogenase-2 gene polymorphism on vasodilatory response of brachial artery induced by nitroglycerin.2010
- Author(s)
  Sakata S, Matsumura K, Miwa Y, Oniki H, Ichishima K, Arima H, Takahashi-Yanaga F, Yoshihara T, Shiraishi F, Iida M, Sasaguri T
- Organizer
  23rd Scientific Meeting of the International Society of Hypertension
- Place of Presentation
  バンクーバー
- Data Source
  KAKENHI-PROJECT-20390160
[Presentation] 酸化ストレス誘発小腸腫瘍に対するDifferentiation-inducingfactor-1の抗腫瘍効果2010
- Author(s)
  高橋富美、吉原達也、中津可道、績輝久、中別府雄作、笹栗俊之
- Organizer
  第69回日本癌学会学術総会
- Place of Presentation
  大阪
- Year and Date
  2010-09-22
- Data Source
  KAKENHI-PROJECT-21590284
[Presentation] 2型アルデヒド脱水素酵素の遺伝子多型がニトログリセリンおよび二硝酸イソソルビドの血管拡張作用に及ぼす影響2010
- Author(s)
  坂田智子, 松村潔, 三輪宜一, 鬼木秀幸, 市島久仁彦, 吉原達也, 高橋富美, 白石富美恵, 大坪俊夫, 笹栗俊之
- Organizer
  第33回日本高血圧学会年会
- Place of Presentation
  福岡
- Data Source
  KAKENHI-PROJECT-20390160
[Presentation] Differentiation-inducingfactor-1はVEGFR2の発現を低下させることによりin vitroおよびinvivoにおいて血管新生を阻害する2009
- Author(s)
  吉原達也、高橋富美、笹栗俊之
- Organizer
  第68回日本癌学会
- Place of Presentation
  横浜
- Year and Date
  2009-10-01
- Data Source
  KAKENHI-PROJECT-21590284
[Presentation] Differentiation-inducing factor-1はVEGFR2の発現を低下させることにより in vitro および in vivo において血管新生を阻害する2009
- Author(s)
  吉原達也, 高橋寓美, 笹栗俊之
- Organizer
  第68回日本癌学会
- Place of Presentation
  横浜
- Year and Date
  2009-10-01
- Data Source
  KAKENHI-PROJECT-21590284
[Presentation] MRP4の遺伝子多型がトリクロルメチアジド投与後の血清尿酸値と尿酸クリアランスに及ぼす影響
- Author(s)
  吉原達也、今井浩光、白石富美恵、有馬久富、高橋富美、池松秀之、小手川勤、笹栗俊之
- Organizer
  第35回日本臨床薬理学会学術総会
- Place of Presentation
  松山市
- Year and Date
  2014-12-04 – 2014-12-06
- Data Source
  KAKENHI-PROJECT-24390140
[Presentation] Acceleration of bone regeneration by local application of GSK-3 inhibitors.
- Author(s)
  Masaki Arioka, Fumi Yanaga-Takahashi, Masanori Sasaki, Yoshiko Inoue, Toshiyuki Sasaguri.
- Organizer
  EAO Congress ROMA 2014
- Place of Presentation
  ローマ、イタリア
- Year and Date
  2014-09-25 – 2014-09-27
- Data Source
  KAKENHI-PROJECT-25463090
[Presentation] Detection of cardiac troponin T in detrusor smooth muscle. -Does troponin system operate in smooth muscle?-
- Author(s)
  Kajioka S, Takahashi-Yanaga F, Shahab N, Takahashi R, Matsuda M, Yonemitsu Y, Seki N, Nakayama S, Naito S
- Organizer
  第84回日本薬理学会総会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-23592371
[Presentation] Generosity of cardiac troponin T in smooth muscle and its functional analysis in detrusor smooth muscle
- Author(s)
  Kajioka S, Shahab N, Takahashi-Yanaga F, Takahashi R, Matsuda M, Yonemitsu Y, Seki N, Nakayama S
- Organizer
  第88回日本生理学会総会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-23592371
[Presentation] Differentiation-inducing factor-3 inhibits intestinal tumor growth in vitro and in vivo
- Author(s)
  久保倉尚哉、高橋富美、笹栗俊之
- Organizer
  第88回日本薬理学会年会
- Place of Presentation
  名古屋
- Year and Date
  2015-03-18 – 2015-03-20
- Data Source
  KAKENHI-PROJECT-25460334
[Presentation] DIF-1 inhibits tumor growth in vivo reducing phosphorylation of GSK-3β and expressions of cyclin D1 and TCF7L2
- Author(s)
  高橋富美、中津可道、續輝久、中別府雄作、笹栗俊之
- Organizer
  第73回日本癌学会学術総会
- Place of Presentation
  横浜
- Year and Date
  2014-09-25 – 2014-09-27
- Data Source
  KAKENHI-PROJECT-25460334
[Presentation] Influence of a loss-of-function polymorphism of MRP4 on serum uric acid concentration and uric acid clearance after the administration of trichlormethiazide
- Author(s)
  Tatsuya Yoshihara, Hiromitsu Imai, Fumie Shiraishi, Hisatomi Arima, Fumi Takahashi-Yanaga, Hideyuki Ikematsu, Tsutomu Kotegawa, Toshiyuki Sasaguri
- Organizer
  17th World Congress of Basic and Clinical Pharmacology
- Place of Presentation
  ケープタウン（南アフリカ共和国）
- Year and Date
  2014-07-13 – 2014-07-18
- Data Source
  KAKENHI-PROJECT-24390140

1. SASAGURI Toshiyuki (30261209)

# of Collaborated Projects: 6 results

# of Collaborated Products: 37 results
2. KAJIOKA Shunichi (90274472)

# of Collaborated Projects: 3 results

# of Collaborated Products: 16 results
3. Matsuzaki Etsuko (20432924)

# of Collaborated Projects: 3 results

# of Collaborated Products: 6 results
4. MATSUMURA Kiyoshi (70285469)

# of Collaborated Projects: 2 results

# of Collaborated Products: 5 results
5. WATANABE Yutaka (40114722)

# of Collaborated Projects: 2 results

# of Collaborated Products: 4 results
6. SASAKI Masanori (30346803)

# of Collaborated Projects: 2 results

# of Collaborated Products: 5 results
7. IGAWA KAZUNOBU (80401529)

# of Collaborated Projects: 2 results

# of Collaborated Products: 4 results
8. MORIMOTO Sachio (50202362)

# of Collaborated Projects: 2 results

# of Collaborated Products: 6 results
9. 阿南壽 (80158732)

# of Collaborated Projects: 2 results

# of Collaborated Products: 4 results
10. MINAKO Hirahashi (90529877)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. SEKI Narihito (90294941)

# of Collaborated Projects: 1 results

# of Collaborated Products: 8 results
12. ITO Shinichi (40291520)

# of Collaborated Projects: 1 results

# of Collaborated Products: 13 results
13. YONEMITSU Yoshikazu (40315065)

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
14. NAKAYAMA Shinsuke (30192230)

# of Collaborated Projects: 1 results

# of Collaborated Products: 5 results
15. MATSUMURA Kiyoshi (70285409)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
16. YOSHIHARA Tatsuya (80419613)

# of Collaborated Projects: 1 results

# of Collaborated Products: 10 results
17. OHTSUBO Toshio (30423974)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
18. ARIMA Hisatomi (20437784)

# of Collaborated Projects: 1 results

# of Collaborated Products: 9 results
19. Higashi Yoko (90755042)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
20. Higashi Katsumasa (90778846)

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
21. OHTSUKI Iwao (70009992)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
22. 三輪宜一 (60346773)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
23. 西村英紀 (80208222)

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
24. 石兼真 (40470190)

# of Collaborated Projects: 1 results

# of Collaborated Products: 5 results
25. IKEMATU Hideyuki

# of Collaborated Projects: 1 results

# of Collaborated Products: 8 results
26. SHIRAISHI Fumie

# of Collaborated Projects: 1 results

# of Collaborated Products: 7 results
27. Mohamed Rasha

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
28. TO Seikon

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
29. Zhan Dong-Yun

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
30. OKA Sugako

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
31. 平田雅人

# of Collaborated Projects: 0 results

# of Collaborated Products: 4 results
32. 橋本陽子

# of Collaborated Projects: 0 results

# of Collaborated Products: 3 results
33. 有岡将基

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
34. ZHAN DONGYUN

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
35. 中別府雄作

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
36. 中津可道

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
37. 續輝久

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
38. 高島明彦

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Takahashi Fumi 高橋 富美

TAKAHASHI Fumi 高橋 富美

YANAGA Fumi

Research Projects

Research Products

Co-Researchers

GSK-3活性化作用に基づいた心臓線維化抑制薬開発に向けた基盤研究Principal Investigator

Principal Investigator

Project Period (FY)

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Review Section

Research Institution

Principal Investigator

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Review Section

Research Institution

Identification of the tareget molecule for GSK-3 activator DIF towards clinical usagePrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Principal Investigator

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Examination of the in vivo effect of DIF, an inhibitor of G1 phase transition derived from Dictyostelium, as a new anti-cancer drugPrincipal Investigator

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Examination of the effect of DIF, an inhibitor of G1 phase transition derived from Dictyostelium, as a new anti-cancer drug.Principal Investigator

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Takahashi Fumi 高橋富美

TAKAHASHI Fumi 高橋富美