TSUZUKI Satoshi 都築巧

… Alternative Names

TSUZUKI SATOSHI 都築巧

都筑巧ツヅキサトシ

都築功ツヅキサトシ

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Researcher Number	50283651
Other IDs
External Links
Affiliation (Current)	2023: 京都大学, 農学研究科, 助教
Affiliation (based on the past Project Information) *help	2016 – 2022: 京都大学, 農学研究科, 助教 2014: 京都大学, 大学院農学研究科, 助教 2012 – 2014: 京都大学, (連合)農学研究科(研究院), 助教 2007 – 2012: Kyoto University, 農学研究科, 助教 2011: 京都大学, 大学院・農学研究科, 助教 … More 2008 – 2009: 京都大学, 大学院・農学研究科, 助教 1997 – 2006: 京都大学, 農学研究科, 助手 2005: Kyoto University, Assistant Professor, 助手 2004: 京都大学, 農学研究科, 助教授 2003: 京都大学, 助手 1999: 京都大学, 大学院・農学研究科, 助手 1997: 京都大学, 大学院・農学研究科, 助手 Less
Review Section/Research Field	Principal Investigator Food science / 食品科学・栄養科学 / Basic Section 38050:Food sciences-related / Basic Section 59040:Nutrition science and health science-related Except Principal Investigator Food science / 食品科学・栄養科学 / Biological Sciences
Keywords	Principal Investigator CD36 / コレシストキニン / モニターペプチド / 食品 / クラスBスカベンジャー受容体 / 長鎖脂肪酸 / 脂肪族アルデヒド / SR-B1 / CCK / small intestine … More / receptor / 膵酵素分泌 / 受容体 / 精製 / プロテアーゼ / セリンプロテアーゼ / アノイキス / アポトーシス / 腸管細胞 / 細胞代謝 / 腸上皮 / 代謝回転 / 基底膜 / MT-SP1 / 活性化制御 / 酵素 / 遺伝子 / バイオテクノロジー / 栄養学 / 膵分泌性トリプシン阻害物質 / グランザイムA / 上皮細胞間リンパ球 / 腸管上皮細胞 / ホルモン産生細胞 / 膵分泌性トリプシンインヒビター / 上皮細胞間Tリンパ球 / 小腸上皮細胞 / monitor peptide / pancreatic secretory trypsin inhibitor / cholecystokinin / granzyme A / intraepithelial lymphocytes / intestinal epithelial cells / hormone-producing cells / 酸化型リポ蛋白質 / 酸化型リン脂質 / 嗅上皮 / 酸化型リポタンパク質 / 酸化型リポタンパク室 / SR-BI / 生体分子 / 脂質 / 蛋白質 / 動物 / 食品有香成分 / 模擬受容体ペプチド / 特異的結合 / GST融合タンパク質 / 三次元構造 / 食品有香物質 / 香調ー活性相関 / 結晶構造解析 / 結合試験 / 特異的結合相互作用 / 結合様式 … More Except Principal Investigator FAT / 疲労 / 肥満 / TGF-β / ストレス / エネルギー代謝 / 脂肪酸 / fatty acids / 脂肪 / PPAR / 脂質 / マイクロダイアリシス / microdialysis / 脂肪細胞 / 生活習慣病 / adipocyte / obesity / サイトカイン / cytokine / matrix metalloproteinase / 行動学 / 食品 / 神経科学 / 抗疲労 / 疲労回復 / 脳内報酬系 / 脳内自己刺激 / 脳報酬系 / 消化管ホルモン / 消化管 / ホルモン分泌 / 認識 / CCK / 膵酵素分泌 / 外分泌 / gastrointestinal hormone / gastrointestinal tract / hormone nelease / recognition / 脂質代謝 / 核内受容体 / アゴニスト / アンタゴニスト / OBESITY / LIPID METABOLISM / ENERGY METABOLISM / NUCREAR RECEPTOR / AGONIST / ANTAGONIST / 化学受容 / 舌リパーゼ / オルリスタット / 油脂 / おいしさ / 味蕾細胞 / エブネル腺 / 有郭乳頭 / 口腔内受容 / fat / chemical reception / lingual lipase / orlistat / ノルアドレナリン / ドーパミン / セロトニン / 2瓶選択 / 甘味嗜好性 / 呼吸交換比 / 脳波 / 呼吸商 / noradrenaline / dopamin / serotonin / 2-bottle selection / sweet preferences / respiratory exchange ratio / シグナル伝達 / メタボリックシンドローム / イオンチャンネル / センサー / アディポサイトカイン / イオンチャネル / signal transduction / lipid / life style-related discase / metabolic syndrome / 嗜好性 / 口腔内刺激 / カルシウムイメージング / β酸化阻害 / 報酬効果 / CD36 / エネルギー信号 / 口腔内受容体 / dietary fat / palatability / oral stimulation / calcium imaging / inhibition of beta-oxidation / rewarding effect / 高脂肪食 / ケモカイン / マクロファージ / lifestyle related disease / high fat diet / chemokine / macrophage / 中枢性疲労 / in situ hybridization / リポプロテインリパーゼ / マロニルCoA / central fatigue / TGF-beta Less

長鎖脂肪酸とその細胞への取り込みを担う受容体の特異的結合相互作用の立証Principal Investigator
- Principal Investigator
  
  都築巧
- Project Period (FY)
  2022 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 59040:Nutrition science and health science-related
- Research Institution
  Kyoto University
Elucidation of the mechanisms on the capture and recognition of food odorants that have fatty and waxy notes in the nasal cavity of mammalsPrincipal Investigator
- Principal Investigator
  
  TSUZUKI SATOSHI
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 38050:Food sciences-related
- Research Institution
  Kyoto University
Elucidation of recognition mechanisms of fatty acids and their related substances by class B scavenger receptorsPrincipal Investigator
- Principal Investigator
  
  TSUZUKI SATOSHI
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Food science
- Research Institution
  Kyoto University
Studies on the mechanism of manifestation of fatigue and its effects on the attenuation of motivation to move and on the possibility of their control by ingestion of foods/food components
- Principal Investigator
  
  INOUE Kazuo
- Project Period (FY)
  2012 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Food science
- Research Institution
  Kyoto University
Elucidation of the mechanism of matriptase activation and exploration of food components that control the activation.Principal Investigator
- Principal Investigator
  
  TSUZUKI Satoshi
- Project Period (FY)
  2012 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Food science
- Research Institution
  Kyoto University
Integrative studies on the mechanism of central and peripheral fatigue manifestation and the development of foods that have effects of anti-fatigue and fast restoration from fatigue
- Principal Investigator
  
  INOUE Kazuo
- Project Period (FY)
  2009 – 2011
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Food science
- Research Institution
  Kyoto University
Elucidation of the role of MT-SP1 in the intestinal epithelial turnover and exploration of food components that control the activation of the molecule.Principal Investigator
- Principal Investigator
  
  TSUZUKI Satoshi
- Project Period (FY)
  2009 – 2011
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Food science
- Research Institution
  Kyoto University
Construction of evaluation system of central fatigue and its application to developing basis of food aimed for control of human fatigue
- Principal Investigator
  
  INOUE Kazuo
- Project Period (FY)
  2006 – 2008
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Food science
- Research Institution
  Kyoto University
Elucidation of significance of serine proteases found in the intestines on cell death and the mechanism of the proteases-mediated cell death regulated by food componentsPrincipal Investigator
- Principal Investigator
  
  TSUZUKI Satoshi
- Project Period (FY)
  2006 – 2008
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Food science
- Research Institution
  Kyoto University
Analysis of the mechanisms on chemical reception and producing energy signal after dietary fat intake for cause investigation of its high palatability.
- Principal Investigator
  
  FUSHIKI Tohru
- Project Period (FY)
  2004 – 2005
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Food science
- Research Institution
  Kyoto University
Molecular mechanism of common disease-induced cytokine expressions in dietary fat-target cells
- Principal Investigator
  
  KAWADA Teruo
- Project Period (FY)
  2004 – 2006
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Food science
- Research Institution
  Kyoto University
Function of cytokine in the brain in manifestation of central fatigue and its involvement to the regulation of metabolism
- Principal Investigator
  
  INOUE Kazuo
- Project Period (FY)
  2004 – 2005
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Food science
- Research Institution
  Kyoto University
Analysis of Molecular Mechanisms that Monitor Hypertrophy of Adipocytes
- Principal Investigator
  
  KAWADA Teruo
- Project Period (FY)
  2003 – 2007
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Kyoto University
Studies on the role of granzyme A, a binding molecule for monitor peptide, in the CCK release mediated by the peptidePrincipal Investigator
- Principal Investigator
  
  TSUZUKI Satoshi
- Project Period (FY)
  2003 – 2005
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Food science
- Research Institution
  Kyoto University
Mechanisms on the chemical reception of dietary fat in the oral cavity and its signaling to the brain
- Principal Investigator
  
  FUSHIKI Tohru
- Project Period (FY)
  2002 – 2003
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  食品科学・栄養科学
- Research Institution
  KYOTO UNIVERSITY
Studies on the mechanisms of manifestation of central fatigue
- Principal Investigator
  
  INOUE Kazuo
- Project Period (FY)
  2002 – 2003
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  食品科学・栄養科学
- Research Institution
  KYOTO UNIVERSITY
Signal transduction of dietary fat and energy metabolismsthrough nucrea receptor
- Principal Investigator
  
  KAWADA Teruo
- Project Period (FY)
  2001 – 2003
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  食品科学・栄養科学
- Research Institution
  Kyoto University
モニターペプチド-受容体結合によるCCK放出機構の解明Principal Investigator
- Principal Investigator
  
  都築巧
- Project Period (FY)
  2000 – 2001
- Research Category
  
  Grant-in-Aid for Encouragement of Young Scientists (A)
- Research Field
  
  食品科学・栄養科学
- Research Institution
  Kyoto University
CCK放出ペプチド受容体の同定とその生理的意義の解明Principal Investigator
- Principal Investigator
  
  都築巧
- Project Period (FY)
  1997 – 1998
- Research Category
  
  Grant-in-Aid for Encouragement of Young Scientists (A)
- Research Field
  
  食品科学・栄養科学
- Research Institution
  Kyoto University
Recognition of Fatty acids by Gastw intestinal hormone producing cells.
- Principal Investigator
  
  FUSHIKI Tohru
- Project Period (FY)
  1997 – 1999
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  食品科学・栄養科学
- Research Institution
  KYOTO UNIVERSITY

[Journal Article] Application of a novel fluorescence intensity assay: identification of distinct fatty acetates as volatile compounds that bind specifically to amino acid region 149-168 of a transmembrane receptor CD362022
- Author(s)
  Tsuzuki S, Kimoto Y, Marui K, Lee S, Inoue K, Sasaki T.
- Journal Title
  
  Biosci. Biotechnol. Biochem.
  
  Volume: 86 Pages: 509-518
- DOI
  10.1093/bbb/zbac018
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K05912
[Journal Article] Assessment of direct binding interaction between CD36 and its potential lipid ligands using a peptide mimic of the receptor labeled with a fluorophore2021
- Author(s)
  Tsuzuki S, Kimoto Y, Yamasaki M, Sugawara T, Manabe Y, Inoue K, Sasaki T.
- Journal Title
  
  Biomedical Research
  
  Volume: 162 Issue: 5 Pages: 181-191
- DOI
  10.2220/biomedres.42.181
- NAID
  130008090728
- ISSN
  0388-6107, 1880-313X
- Language
  English
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K05912
[Journal Article] A novel role for scavenger receptor B1 as a contributor to the capture of specific volatile odorants in the nasal cavity2018
- Author(s)
  Tsuzuki S, Kimoto Y, Lee S, Sugawara T, Manabe Y, Inoue K
- Journal Title
  
  Biomedical Research
  
  Volume: 印刷中
- NAID
  130007396410
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16K07733
[Journal Article] A role for scavenger receptor B1 as a captor of specific fatty acids in taste buds of circumvallate papillae.2018
- Author(s)
  Tsuzuki S, Lee S, Kimoto Y, Sugawara T, Manabe Y, Inoue K
- Journal Title
  
  Biomedical Research
  
  Volume: 39 Pages: 295-300
- NAID
  130007528462
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16K07733
[Journal Article] A Search for CD36 Ligands from Flavor Volatiles in Foods with an Aldehyde Moiety: Identification of Saturated Aliphatic Aldehydes with 9-16 Carbon Atoms as Potential Ligands of the Receptor.2017
- Author(s)
  Tsuzuki S, Amitsuka T, Okahashi T, Kimoto Y, Inoue K
- Journal Title
  
  Journal of Agricultural and Food Chemistry
  
  Volume: 65 Pages: 6647-6655
- DOI
  10.1021/acs.jafc.7b01890
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16K07733
[Journal Article] CD36 involvement in the olfactory perception of oleic aldehyde, an odour-active volatile compound, in mice2017
- Author(s)
  Lee S, Tsuzuki S, Amitsuka T, Masuda D, Yamashita S, Inoue K.
- Journal Title
  
  Biomedical Research
  
  Volume: not assign
- NAID
  130005757732
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16K07733
[Journal Article] Assessment of direct interaction between CD36 and an oxidized glycerophospholipid species.2017
- Author(s)
  Tsuzuki S, Yamasaki M, Kozai Y, Sugawara T, Manabe Y, Inoue K, Fushiki T.
- Journal Title
  
  Journal of Biochemistry
  
  Volume: not assing
- DOI
  10.1093/jb/mvx019
- NAID
  40021326038
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-16K07733
[Journal Article] Identification of the odor-active volatile compound (Z,Z)-4,7-tridecadienal as a potential ligand for the transmembrane receptor CD36 2016
- Author(s)
 Tsuzuki S, Amitsuka T, Okahashi T, Kozai Y, Yamasaki M, Inoue K, Fushiki T.
- Journal Title
 
 Biomedical Research
 
 Volume: 37 Issue: 6 Pages: 335-342
- DOI
 10.2220/biomedres.37.335
- NAID
 130005252682
- ISSN
 0388-6107, 1880-313X
- Language
 English
- Peer Reviewed
- Data Source
 KAKENHI-PROJECT-16K07733
[Journal Article] Immunohistochemical localization of fatty acid transporters and MCT1 in the sebaceous glands of mouse skin 2016
- Author(s)
 Zheng M, Lee S, Tsuzuki S, Inoue K, Masuda D, Yamashita S, Iwanaga T.
- Journal Title
 
 Biomedical Research
 
 Volume: 37 Issue: 4 Pages: 265-270
- DOI
 10.2220/biomedres.37.265
- NAID
 130005405216
- ISSN
 0388-6107, 1880-313X
- Language
 English
- Peer Reviewed
- Data Source
 KAKENHI-PROJECT-16K07733
[Journal Article] A recombinant matriptase causes an increase in caspase-3 activity in a small-intestinal epithelial IEC-6 line cultured on fibronectin-coated plates2014
- Author(s)
  Seiya Mochida , Satoshi Tsuzuki , Kuniyo Inouye & Tohru Fushiki
- Journal Title
  
  Cytotechnology
  
  Volume: 66 Pages: 357-363
- DOI
  10.1007/s10616-013-9582-2
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24580178
[Journal Article] Roles of CUB and LDL receptor class A domain repeats of a transmembrane serine protease matriptase in its zymogen activation2013
- Author(s)
  Inouye K, Tomoishi M, Yasumoto M, Miyake Y, Kenji Kojima, Tsuzuki S, Fushiki T
- Journal Title
  
  Journal of Biochemistry
  
  Volume: 153 Pages: 51-61
- DOI
  10.1093/jb/mvs118
- NAID
  120005373084
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24580178
[Journal Article] The optimal activity of a pseudozymogen form of recombinant matriptase under the mildly acidic pH and low ionic strength conditions2010
- Author(s)
  Inouye K, Yasumoto M, Tsuzuki S, Mochida S, Fushiki T
- Journal Title
  
  J. Biochem. 147
  
  Pages: 485-492
- NAID
  10027874930
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21580138
[Journal Article] The Structural Requirements of Matriptase in Its Ectodomain Release in Polarized Epithelial Cells2010
- Author(s)
  Tsuzuki S, Murai N, Miyake Y, Inouye K, Fushiki T.
- Journal Title
  
  Biosci. Biotechnol. Biochem.
  
  Volume: 74 Issue: 6 Pages: 1295-1297
- DOI
  10.1271/bbb.100074
- NAID
  10027556665
- ISSN
  0916-8451, 1347-6947
- Language
  English
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21580138
[Journal Article] Granzyme A and thrombin differentially promote the release of interleukin-8 from alveolar epithelial A549 cells.2010
- Author(s)
  Yoshikawa Y, Hirayasu H, Tsuzuki S, Fushiki T
- Journal Title
  
  Cytotechnology
  
  Volume: 62 Pages: 325-332
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21580138
[Journal Article] Matriptase Does Not Require Hepatocyte Growth Factor Activator Inhibitor Type-1 for Activation in an Epithelial Cell Expression Model2010
- Author(s)
  Miyake Y, Tsuzuki S, Fushiki T, Inouye K.
- Journal Title
  
  Biosci. Biotechnol. Biochem.
  
  Volume: 74 Issue: 4 Pages: 848-850
- DOI
  10.1271/bbb.90696
- NAID
  10027554197
- ISSN
  0916-8451, 1347-6947
- Language
  English
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21580138
[Journal Article] A recombinant catalytic domain of matriptase induces detachment and apoptosis of small-intestinal epithelial IEC-6 cells cultured on laminin-coated surface.2010
- Author(s)
  Mochida S, Tsuzuki S, Inouye K, Fushiki T
- Journal Title
  
  J Biochem
  
  Volume: 148 Pages: 721-732
- NAID
  10027879947
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21580138
[Journal Article] The structural requirements of matriptase in its ectodomain release in polarized epithelial cells.2010
- Author(s)
  Tsuzuki S, Murai N, Miyake Y, Inouye K, Fushiki T
- Journal Title
  
  Biosci Biotechnol Biochem
  
  Volume: 74 Pages: 1295-1297
- NAID
  10027556665
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21580138
[Journal Article] The role of asparagine-linked glycosylation site on thecatalytic domain of matriptase in itszymogen activation2010
- Author(s)
  Miyake Y, Tsuzuki S, Mochida S, Fushiki T, Inouye K.
- Journal Title
  
  Biochim. Biophys. Acta
  
  Volume: 1804 Pages: 156-165
- DOI
  10.1016/j.bbapap.2009.09.025
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21580138
[Journal Article] Matriptase does not require hepatocyte growth factor activator inhibitor type-1 for activation in an epithelial cell expression model2010
- Author(s)
  Miyake Y, Tsuzuki S, Fushiki T, Inouye K
- Journal Title
  
  Biosci. Biotechnol. Biochem. (in press)
- NAID
  10027554197
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21580138
[Journal Article] The optimal activity of a pseudozymogen form of recombinantmatriptase under the mildly acidic pHand low ionic strength conditions2010
- Author(s)
  Inouye K, Yasumoto M, Tsuzuki S, Mochida S, Fushiki T.
- Journal Title
  
  J. Biochem.
  
  Volume: 147 Pages: 485-492
- DOI
  10.1093/jb/mvp190
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21580138
[Journal Article] The role of asparagine-linked glycosylation site on the catalytic domain of matriptase in its zymogen activation2010
- Author(s)
  Miyake Y, Tsuzuki S, Mochida S, Fushiki T, Inouye K
- Journal Title
  
  Biochim. Biophys. Acta 1804
  
  Pages: 156-165
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21580138
[Journal Article] A recombinant catalytic domain ofmatriptase induces detachment and apoptosis of small-intestinal epithelial IEC-6 cells cultured on laminin coated surface2010
- Author(s)
  Mochida S, Tsuzuki, S, Inouye K, Fushiki T.
- Journal Title
  
  J. Biochem.
  
  Volume: 148 Pages: 721-732
- DOI
  10.1093/jb/mvq108
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21580138
[Journal Article] The structural requirements of matriptase in its ectodomain release in polarized epithelial cells2010
- Author(s)
  Tsuzuki S, Murai N, Miyake Y, Inouye K, Fushiki T
- Journal Title
  
  Biosci. Biotechnol. Biochem. (in press)
- NAID
  10027556665
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21580138
[Journal Article] The Occurrence of Matriptase C-Terminal Fragments on the Apical and Basolateral Sides of Madin-Darby Canine Kidney Epithelial Cells2009
- Author(s)
  Tsuzuki S, Miyake Y, Inouye K, Fushiki T.
- Journal Title
  
  Biosci. Biotechnol. Biochem.
  
  Volume: 73 Issue: 11 Pages: 2538-2540
- DOI
  10.1271/bbb.90431
- NAID
  10027548270
- ISSN
  0916-8451, 1347-6947
- Language
  English
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21580138
[Journal Article] Activation of amembrane-bound serine protease matriptaseon the cell surface2009
- Author(s)
  Miyake Y, Yasumoto M, Tsuzuki S, Fushiki T, Inouye K
- Journal Title
  
  J. Biochem.
  
  Volume: 146
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21580138
[Journal Article] Involvement of the cytoplasmic juxtamembrane region of matriptase in its exclusive localization to the basolateral membrane domain of Madin-Darby canine Kidney epithelial cells2009
- Author(s)
  Murai N, Miyake Y, Tsuzuki S, Inouye K, Fushiki T
- Journal Title
  
  Cytotechnology 53
  
  Pages: 169-176
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21580138
[Journal Article] The activity of a type II transmembrane serine protease, matriptase, is dependent solely on the catalytic domain2009
- Author(s)
  Kojima K, Tsuzuki S, Fushiki T, Inouye K
- Journal Title
  
  Biosci. Biotechnol. Biochem 73
  
  Pages: 454-456
- NAID
  10027537869
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18580118
[Journal Article] Involvement of the cytoplasmic juxtamembrane region of matriptase in its exclusive localization to the basolateral membrane domain of Madin-Darby canine kidney epithelial cells.2009
- Author(s)
  Murai N, Miyake Y, Tsuzuki S, Inouye K Fushiki T
- Journal Title
  
  Cytotechnology
  
  Volume: 53 Pages: 169-176
- DOI
  10.1007/s10616-009-9205-0
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21580138
[Journal Article] Secreted expression of pseudozymogen forms of recombinant matriptase in Pichia Pastoris2009
- Author(s)
  Mochida S, Tsuzuki S, Yasumoto M, Inouye K, Fushiki T
- Journal Title
  
  Enzyme Microb. Technol. 45
  
  Pages: 288-294
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21580138
[Journal Article] Requirement of the activity of hepatocyte growth factor activator inhibitor type 1 for the extracelular appearance of a transmembrane serine protease matriptase in monkey kidney COS-1 cells2009
- Author(s)
  Miyake Y, Tsuzuki S, Yasumoto M, Fushiki T, Inouye K
- Journal Title
  
  Cytotechnology 60
  
  Pages: 95-103
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21580138
[Journal Article] Secreted expression of pseudozymogen forms of recombinant matriptase in Pichia Pastoris2009
- Author(s)
  Mochida S, Tsuzuki S, Yasumoto M, Inouye K, Fushiki T
- Journal Title
  
  Enzyme Microb. Technol
  
  Volume: 45 Pages: 288-294
- DOI
  10.1016/j.enzmictec.2009.06.008
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21580138
[Journal Article] Roles of the stem domain of matriptase in the interaction with its physiological inhibitor, hepatocyte growth factor activator inhibitor type I2009
- Author(s)
  Kojima K, Tsuzuki S, Fushiki T, Inouye K
- Journal Title
  
  J. Biochem.
- NAID
  10025187084
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18580118
[Journal Article] Requirement of the activity of hepatocyte growth factor activator inhibitor type 1 for the extracellular appearance of a trans-membrane serine protease matriptase in monkey kidney COS-1 cells.2009
- Author(s)
  Miyake Y, Tsuzuki S, Yasumoto M, Fushiki T Inouye K.
- Journal Title
  
  Cytotechnology
  
  Volume: 60 Pages: 95-103
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21580138
[Journal Article] Activation of a Membrane-bound serine protease matriptase on the cell surface2009
- Author(s)
  Miyake Y, Yasumoto M, Tsuzuki S, Fushiki T, Inouye K
- Journal Title
  
  J. Biochem. 146
  
  Pages: 783-790
- NAID
  10026302976
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21580138
[Journal Article] The occurrence of matriptase C-terminal fragments on the apical and basolateral sides of Madin-Darby canine kidney epithelial cells2009
- Author(s)
  Tsuzuki S, Miyake Y, Inouye K, Fushiki T
- Journal Title
  
  Biosci. Biotechnol. Biochem. 73
  
  Pages: 2538-2540
- NAID
  10027548270
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21580138
[Journal Article] A lymphocyte serine protease granzyme A causes detachment of a small-intestinal epithelial cell line(IEC-6)2008
- Author(s)
  Hirayasu H, Yoshikawa Y, Tsuzuki S, Fushiki T
- Journal Title
  
  Biosci. Biotechnol. Biochem 72
  
  Pages: 2294-2302
- NAID
  10027531759
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18580118
[Journal Article] Carrageenan inhibits granzyme A-induced detachment of and interleukin-8 release from alveolar epithelial A549 cells2008
- Author(s)
  Yoshikawa Y, Hirayasu H, Tsuzuki S, Fushiki T
- Journal Title
  
  Cytotechnology 58
  
  Pages: 63-67
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18580118
[Journal Article] A lymphocyte serine protease granzyme A causes detachment of a small-intestinal epithelial cell line (IEC-6)2008
- Author(s)
  Hirayasu H, Yoshikawa, Y, Tsuzuki S, Fushiki T
- Journal Title
  
  Biosci. Biotechnol. Biochem 72
  
  Pages: 2294-2302
- NAID
  10027531759
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18580118
[Journal Article] Development of an in vitro system for screening the ligands of a membrane glycoprotein CD362008
- Author(s)
  Inagaki H, Tsuzuki S, Iino T, Inoue K, Fushiki T
- Journal Title
  
  Cytotechnology 57
  
  Pages: 145-150
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18580118
[Journal Article] Roles of functional and structural domains of hepatocyte growth factor activator inhibitor type I in the inhibition of matriptase2008
- Author(s)
  Kojima K, Tsuzuki S, Fushiki T, Inouye K
- Journal Title
  
  J. Biol. Chem 283
  
  Pages: 2478-2487
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18580118
[Journal Article] Granzyme A causes detachment of alveolar epithelial A549 cells accompanied by promotion of interleukin-8 release2008
- Author(s)
  Yoshikawa Y, Hirayasu H, Tsuzuki S, Fushiki T
- Journal Title
  
  Biosci. Biotechnol. Biochem 72
  
  Pages: 2481-2484
- NAID
  10027532433
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18580118
[Journal Article] A role of a lymphocyte tryptase, granzyme A, in experimental ulcerative colitis2007
- Author(s)
  Hirayasu H, Yoshikawa Y, Tsuzuki S, Fushiki T
- Journal Title
  
  Biosci. Biotechnol. Biochem 71
  
  Pages: 234-237
- NAID
  10027510632
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18580118
[Journal Article] A role of a lymphocyte tryptase, granzyme A, in experimental ulcerative colitis.2007
- Author(s)
  Hirayasu H, Yoshikawa Y, Tsuzuki S, Fushiki T.
- Journal Title
  
  Biosci. Biotechnol. Biochem. 71 (1)
  
  Pages: 234-237
- NAID
  10027510632
- Data Source
  KAKENHI-PROJECT-18580118
[Journal Article] Sulfated polysaccharides derived from dietary seaweeds increase the esterase activity of alymphocyte tryptase, granzyme A.2005
- Author(s)
  Hirayasu Y, Yoshikawa Y, Tsuzuki S, Fushiki T.
- Journal Title
  
  J.Nutr.Sci.Vitaminol. 51(6)
  
  Pages: 475-477
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15580106
[Journal Article] Sulfated polysaccharides derived from dietary seaweeds increase the esterase activity of a lymphocyte tryptase, granzyme A2005
- Author(s)
  Hirayasu Y, Yoshikawa Y, Tsuzuki S, Fushiki T
- Journal Title
  
  Journal of Nutritional Science and Vitaminology 51・6
  
  Pages: 475-477
- NAID
  110002978363
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15580106
[Journal Article] Evidence for the occurrence of membrane-type serine protease 1/matriptase on the basolateral sides of enterocytes2005
- Author(s)
  Tsuzuki S, Murai N, Miyake Y, et al.
- Journal Title
  
  Biochemical Journal 388・2
  
  Pages: 679-687
- Data Source
  KAKENHI-PROJECT-15580106
[Journal Article] 腸管粘膜上皮の細胞代謝を調節するセリンプロテアーゼおよびインヒビターに関する分子栄養学的研究2004
- Author(s)
  都築巧
- Journal Title
  
  日本栄養・食糧学会誌 57・6
  
  Pages: 277-282
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15580106
[Journal Article] Molecular nutritional studies on serine proteases and their inhibitors that regulated cell turnover of intestinal mucosal epithelium.2004
- Author(s)
  Tsuzuki S.
- Journal Title
  
  J. pn.Soc.Nutr.Food.Sci. 57(6)
  
  Pages: 277-282
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15580106
[Journal Article] Purification and identification of a binding protein for pancreatic secretory trypsin inhibitor : a novel role of the inhibitor asan anti-granzymeA.2003
- Author(s)
  Tsuzuki S, Kokado Y, Satomi S, Yamasaki Y, Hirayasu H, Iwanaga T, Fushiki T.
- Journal Title
  
  Biochem.J. 372(1)
  
  Pages: 227-233
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15580106
[Journal Article] Purification and identification of a binding protein for pancreatic secretory trypsin inhibitor : a novel role of the inhibitor as an anti-granzymeA2003
- Author(s)
  Tsuzuki S, Kokado Y, Satomi S, et al.
- Journal Title
  
  Biochemical Journal 372・1
  
  Pages: 227-233
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15580106
[Journal Article] Purification and identification of a binding protein for pancreatic secretory trypsin inhibitor : a novel role of the inhibitor as an anti-granzyme A2003
- Author(s)
  Tsuzuki S, Kokado Y, Satomi S et al.
- Journal Title
  
  Biochemical Journal 372・1
  
  Pages: 227-233
- Data Source
  KAKENHI-PROJECT-15580106
[Journal Article] Membrane-type serine protease1の構造と機能2003
- Author(s)
  都築巧, 伏木亨
- Journal Title
  
  日本応用酵素協会誌 38
  
  Pages: 11-18
- Data Source
  KAKENHI-PROJECT-15580106
[Journal Article] Inhibition of membrane-type serine protease 1/matriptase by natural and synthetic protease inhibitors2003
- Author(s)
  Yamasaki Y, Satomi S, Murai N, Tsuzuki S, Fushiki T.
- Journal Title
  
  Journal of Nutritional Science and Vitaminology 49・1
  
  Pages: 27-32
- NAID
  130001377277
- Data Source
  KAKENHI-PROJECT-15580106
[Journal Article] Roles of the stem domain of matriptase in the interaction with its physiological inhibitor, hepatocyte growth factor activator inhibitor type I
- Author(s)
  Kojima K, Tsuzuki S, Fushiki T, Inouye K
- Journal Title
  
  J. Biochem (in press)
- NAID
  10025187084
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18580118
[Journal Article] Evidence for the occurrence of membrane-type serine protease 1/matriptase on the basolateral sides of enterocytes
- Author(s)
  Tsuzuki S, Murai N, Miyake Y, et al.
- Journal Title
  
  Biochemical Journal (印刷中)
- Data Source
  KAKENHI-PROJECT-15580106
[Presentation] 蛍光標識化ペプチドを用いたCD36リガンドアッセイ系の構築と新規リガンド探索2020
- Author(s)
  都築巧、木本悠作、丸井啓太、佐々木努、井上和生
- Organizer
  第59回　日本栄養・食糧学会近畿支部大会
- Data Source
  KAKENHI-PROJECT-19K05912
[Presentation] CD36 ligand activities of flavor volatiles in foods with an aldehyde moiety: Identification of saturated aliphatic aldehydes with 9-16 carbon atoms as potential ligands of the receptor2018
- Author(s)
  Tsuzuki S (speaker), Amitsuka T, Okahashi T, Kimoto Y, Inoue K
- Organizer
  256th National Meeting and Exposition of the American-Chemical-Society (ACS)
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K07733
[Presentation] クラスBスカベンジャー受容体に対するリガンド結合評価のためのin vitro アッセイ系の確立2018
- Author(s)
  木本悠作、都築巧、井上和生
- Organizer
  日本農芸化学会
- Data Source
  KAKENHI-PROJECT-16K07733
[Presentation] 小腸上皮細胞の剥離を促すセリンプロテアーゼと硫酸化多糖による阻害2011
- Author(s)
  都築巧
- Organizer
  Hindgut Club JAPANシンポジウム
- Place of Presentation
  東京(専修大学)(招待講演)
- Year and Date
  2011-12-17
- Data Source
  KAKENHI-PROJECT-21580138
[Presentation] 小腸上皮細胞の剥離を促すセリンプロテアーゼと硫酸化多糖による阻害2011
- Author(s)
  都築巧
- Organizer
  Hindgut Club JAPANシンポジウム(招待講演)
- Place of Presentation
  東京(専修大学)
- Year and Date
  2011-12-17
- Data Source
  KAKENHI-PROJECT-21580138
[Presentation] 肝細胞増殖因子アクチベーター阻害物質I型 (HAI-1)によるマトリプターゼ阻害機構2009
- Author(s)
  都築巧, ら
- Organizer
  日本生化学会
- Place of Presentation
  神戸(神戸国際会議場)
- Year and Date
  2009-10-24
- Data Source
  KAKENHI-PROJECT-21580138
[Presentation] 肝細胞増殖因子アクチベーター阻害物質I型(HAI-1)によるマトリプターゼ阻害機構2009
- Author(s)
  都築巧
- Organizer
  日本生化学会
- Place of Presentation
  神戸(神戸国際会議場)
- Year and Date
  2009-10-24
- Data Source
  KAKENHI-PROJECT-21580138
[Presentation] グランザイムAによる炎症メディエーターの放出機構の解明2007
- Author(s)
  都築巧ら
- Organizer
  日本栄養・食糧学会
- Place of Presentation
  京都(国立京都国際会館)
- Year and Date
  2007-05-20
- Data Source
  KAKENHI-PROJECT-18580118
[Presentation] グランザイムAによる炎症メディエーター放出機構の解明2007
- Author(s)
  都築巧
- Organizer
  日本栄養・食糧学会
- Place of Presentation
  京都(国立京都国際会館)
- Year and Date
  2007-05-20
- Data Source
  KAKENHI-PROJECT-18580118
[Presentation] マトリプターゼLDL受容体クラスAドメインの意義解明
- Author(s)
  友石満里絵、都築巧、安元誠、伏木亨、兒島憲二、井上國世
- Organizer
  第59回日本生化学会近畿支部例会
- Place of Presentation
  京都大学　宇治おうばくプラザ
- Data Source
  KAKENHI-PROJECT-24580178
[Presentation] マトリプターゼ前駆体の酵素活性に対するLDL受容体クラスAドメインの役割解明
- Author(s)
  友石満里絵、都築巧、安元誠、伏木亨、兒島憲二、井上國世
- Organizer
  2012年度　日本農芸化学会　関西支部大会（第476回講演会）
- Place of Presentation
  京都学園大学
- Data Source
  KAKENHI-PROJECT-24580178

1. INOUE Kazuo (80213148)

# of Collaborated Projects: 15 results

# of Collaborated Products: 10 results
2. KAWADA Teruo (10177701)

# of Collaborated Projects: 9 results

# of Collaborated Products: 0 results
3. FUSHIKI Tohru (20135544)

# of Collaborated Projects: 4 results

# of Collaborated Products: 0 results
4. 山崎正幸 (80397562)

# of Collaborated Projects: 3 results

# of Collaborated Products: 3 results
5. 真鍋祐樹 (20730104)

# of Collaborated Projects: 3 results

# of Collaborated Products: 4 results
6. OHNUKI Koichiro (50378668)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
7. INOUYE Kuniyo (10223249)

# of Collaborated Projects: 2 results

# of Collaborated Products: 25 results

TSUZUKI Satoshi 都築 巧

TSUZUKI SATOSHI 都築 巧

都筑 巧 ツヅキ サトシ

都築 功 ツヅキ サトシ

Research Projects

Research Products

Co-Researchers

長鎖脂肪酸とその細胞への取り込みを担う受容体の特異的結合相互作用の立証Principal Investigator

Principal Investigator

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Elucidation of the mechanisms on the capture and recognition of food odorants that have fatty and waxy notes in the nasal cavity of mammalsPrincipal Investigator

Principal Investigator

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Elucidation of recognition mechanisms of fatty acids and their related substances by class B scavenger receptorsPrincipal Investigator

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Elucidation of the mechanism of matriptase activation and exploration of food components that control the activation.Principal Investigator

Principal Investigator

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Principal Investigator

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Elucidation of the role of MT-SP1 in the intestinal epithelial turnover and exploration of food components that control the activation of the molecule.Principal Investigator

Principal Investigator

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Principal Investigator

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Elucidation of significance of serine proteases found in the intestines on cell death and the mechanism of the proteases-mediated cell death regulated by food componentsPrincipal Investigator

Principal Investigator

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Principal Investigator

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Principal Investigator

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Principal Investigator

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Studies on the role of granzyme A, a binding molecule for monitor peptide, in the CCK release mediated by the peptidePrincipal Investigator

Principal Investigator

TSUZUKI Satoshi 都築巧

TSUZUKI SATOSHI 都築巧

都筑巧ツヅキサトシ

都築功ツヅキサトシ