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HASHIMOTO Osamu  橋本 修

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橋本 修  ハシモト オサム

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Researcher Number 50289427
Affiliation (Current) 2025: 久留米大学, 医学部, 助教
Affiliation (based on the past Project Information) *help 2011 – 2012: 久留米大学, 医学部, 助教
2007 – 2009: Kurume University, 医学部, 助教
2006: Kurume University, Second Department of Internal Medicine, Assistant, 医学部, 助手
2000 – 2004: 久留米大学, 医学部, 助手
2001: Medical Institute of Bioregulation, Kyushu University, Assistant Professor, 生体防御医学研究所, 助手
Review Section/Research Field
Principal Investigator
Gastroenterology / Gastroenterology
Except Principal Investigator
Gastroenterology / Gastroenterology / Immunology / Food science
Keywords
Principal Investigator
Weel / 抗酸化 / 薬理学 / 癌 / 抗癌剤 / 抗酸化作用 / 肝癌の治療 / 肝癌治療 / メチル化カテキン / apoptosis … More / G2 arrest / PD0166285 / PD1660285 / Weel inhibitor / 細胞周期 / Hep3B / 遺伝子治療 … More
Except Principal Investigator
PYY_<3-36> / NASH / 脂肪肝 / IL-1 / COX2 / MHC / 酸化ストレス / Oxidative stress / Fatty liver / HEPATITIS C VIRUS / LIPOMICS / DEDIFFERENTIATION / PPAR α ACTIVATOR / HEPATOMA CELL / HEPATIC STELLATE CELL / フィノフィブレート / 肝細胞癌 / PPARγ / 肝細胞脂肪変性 / 肝発癌 / transgenic mouse / HCV-Core蛋白 / フェノフィブレート / PPARα / C型肝炎ウイルス / Lipomics / 脱分化 / PPARα activator / 肝癌細胞 / 肝星細胞 / autoimmunity / positive and negative selection / antigenic peptides / T cell receptor / CDR3 / ペプチド複合体 / 単一MHC / T細胞レパートリー / TCR / 正の選択 / 胸腺内T細胞分化 / 自己免疫 / 正と負の選択 / 抗原ペプチド / T細胞受容体 / 主要組織適合抗原 / 蛋白質量分析 / 卵白アレルゲン / 卵白オボムコイド / 鶏卵アレルギー / 質量分析 / 低アレルゲン食品 / 通電処理 / 食物アレルギー / 蛋白高次構造 / プロテオミクス / 直流電流 / オボムコイド / 低アレルゲン化 / 卵アレルゲン / 卵アレルギー / コリン欠乏食 / メチオニン / KKA^yマウス / サイトカイン / メチオニン/コリン欠乏食 / インスリン抵抗性 / 炎症 / メチル化カテキン / 治療 / 非アルコール性脂肪性肝炎(NASH) Less
  • Research Projects

    (8 results)
  • Research Products

    (12 results)
  • Co-Researchers

    (14 People)
  •  Structural changes accompanying mitigation of the allergic action ofovomucoid after passing an electric current

    • Principal Investigator
      MATSUMOTO Tomoaki
    • Project Period (FY)
      2010 – 2012
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Food science
    • Research Institution
      Kumamoto University
  •  Whether methylated-(3")-epigallocatechin gallate is useful for the therapy of NASH(nonalcoholic steatohepatitis)?

    • Principal Investigator
      UENO Takato
    • Project Period (FY)
      2009 – 2011
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Gastroenterology
    • Research Institution
      Kurume University
  •  3"O-methylEGCG (metylated-(3")-epigallocatechin gallate) regulated the cellular proliferation in hepatoma cell line Huh7 in vitro and in vivo.Principal Investigator

    • Principal Investigator
      HASHIMOTO Osamu
    • Project Period (FY)
      2007 – 2009
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Gastroenterology
    • Research Institution
      Kurume University
  •  Research for usefulness of intestinal peptide, PYY_<3-36> for therapeutic agents of fatty liver and NASH

    • Principal Investigator
      UENO Takato
    • Project Period (FY)
      2004 – 2006
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Gastroenterology
    • Research Institution
      Kurume University
  •  細胞周期チェックポイントWeelを標的とした癌治療の研究Principal Investigator

    • Principal Investigator
      橋本 修
    • Project Period (FY)
      2003 – 2004
    • Research Category
      Grant-in-Aid for Young Scientists (B)
    • Research Field
      Gastroenterology
    • Research Institution
      Kurume University
  •  肝癌細胞増殖抑制へのWeel分子の役割の解明と肝癌の遺伝子治療への応用Principal Investigator

    • Principal Investigator
      橋本 修
    • Project Period (FY)
      2001 – 2002
    • Research Category
      Grant-in-Aid for Young Scientists (B)
    • Research Field
      Gastroenterology
    • Research Institution
      Kurume University
  •  ROLE OF PPARα HUMAN HEPATIC STELLATE CELL AND HEPATOMA CELL

    • Principal Investigator
      UENO Takato
    • Project Period (FY)
      2000 – 2002
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Gastroenterology
    • Research Institution
      KURUME UNIVERSITY
  •  Molecular basis for T cell repertoire selection in the thymus

    • Principal Investigator
      FUKUI Yoshinori, SASAZUKI Takehiko
    • Project Period (FY)
      1999 – 2001
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Immunology
    • Research Institution
      KYUSHU UNIVERSITY

All 2010 2009 2008 2007

All Journal Article Presentation Patent

  • [Journal Article] Epigallocatechin-3-gallate improves nonalcoholic steatohepatitis model mice expressing nuclear sterol regulatory element binding protein-1c in adipose tissue2009

    • Author(s)
      Ueno T, Torimura T, Nakamura T, Sivakumar R, Nakayama H, Otabe S, Yuan X, Yamada K, Hashimoto O, Inoue K, Koga H, Sata M
    • Journal Title

      International Journal of Molecular Medicine 24

      Pages: 12-22

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21590864
  • [Journal Article] Epigallocatechin-3-gallate improves nonalcoholic steatohepatitis model mice expressing nuclear sterol regulatory element binding protein-1c in adipose tissue2009

    • Author(s)
      Ueno T, Torimura T, Nakamura T, Sivakumar R, Nakayama H, Otabe S, Yuan X, Yamada K, Hashimoto O, Inoue K, Koga H, Sata M
    • Journal Title

      Int J Mol Med

      Volume: 24 Pages: 12-22

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21590864
  • [Patent] 非アルコール性脂肪性肝炎の改善用組成物2010

    • Inventor(s)
      上野隆登,橋本修
    • Industrial Property Rights Holder
      久留米大学
    • Industrial Property Number
      2010-172131
    • Filing Date
      2010-07-30
    • Data Source
      KAKENHI-PROJECT-21590864
  • [Patent] 非アルコール性脂肪性肝炎の改善用組成物2010

    • Inventor(s)
      上野隆登 橋本修
    • Industrial Property Rights Holder
      久留米大学
    • Industrial Property Number
      2010-172131
    • Filing Date
      2010-07-30
    • Data Source
      KAKENHI-PROJECT-21590864
  • [Patent] メチル化エピガロカテキンガレート含有抗癌剤組成物2008

    • Inventor(s)
      橋本修
    • Industrial Property Rights Holder
      学校法人久留米大学
    • Filing Date
      2008-08-22
    • Overseas
    • Data Source
      KAKENHI-PROJECT-19590797
  • [Patent] メチル化カテキンを応用した抗癌剤の開発2008

    • Inventor(s)
      橋本修
    • Industrial Property Rights Holder
      橋本修
    • Filing Date
      2008-08-22
    • Data Source
      KAKENHI-PROJECT-19590797
  • [Patent] メチル化カテキン含有抗癌剤組成物2008

    • Inventor(s)
      橋本修
    • Industrial Property Rights Holder
      橋本修
    • Filing Date
      2008-02-25
    • Data Source
      KAKENHI-PROJECT-19590797
  • [Presentation] 緑茶カテキンはNASH(非アルコール性脂肪性肝炎)を改善する-nSREBP1cトランスジェニックNASHモデルマウスによる検討-2009

    • Author(s)
      上野隆登、中村徹、中山ひとみ、小田辺修一、山田研太郎、森田恭代、橋本修、岩本英希、鳥村拓司、佐田通夫
    • Organizer
      第45回日本肝臓学会総会
    • Place of Presentation
      神戸
    • Year and Date
      2009-06-04
    • Data Source
      KAKENHI-PROJECT-21590864
  • [Presentation] Molecular targeted therapy using natural food, Benifuki Tea methylEGCG(Metylated-(3)-epigallocatechin gallate) in hepatoma2009

    • Author(s)
      Hashimoto O
    • Organizer
      3rd International Kobe Liver Symposium on HCC with a JSH-ILCA Joint Scientific Session
    • Place of Presentation
      Kobe, Japan
    • Year and Date
      2009-06-07
    • Data Source
      KAKENHI-PROJECT-21590864
  • [Presentation] Molecular targeted therapy using natural food, Benifuki Tea methylegcg(Metylated-(3")-epigallocatechin gallate)in hepatoma -in vitro and in vivo approach-2009

    • Author(s)
      橋本修, 鳥村拓司, 中村徹, 岩本英希, 上野隆登, 佐田通夫
    • Organizer
      3rd International Kobe Liver Symposium on HCC with a JSH-ILCA Joint Scientific Session
    • Place of Presentation
      Kobe
    • Year and Date
      2009-06-07
    • Data Source
      KAKENHI-PROJECT-21590864
  • [Presentation] The Methylated-(3")-epigallocatechin gallate ; MethylEGCG inhibits cell growth both in vitro and in vivo in a Huh7 hepatoma cell line2008

    • Author(s)
      Osamu Hashimoto
    • Organizer
      AACR
    • Place of Presentation
      San Diego
    • Year and Date
      2008-04-13
    • Data Source
      KAKENHI-PROJECT-19590797
  • [Presentation] 3"0-methylEGCG(metylated-(3")-epigallocatechin gallate)regulated the cellular proliferation in hepatoma cell line Huh7 in vitro and in vivo2007

    • Author(s)
      Osamu Hashimoto
    • Organizer
      日本癌学会
    • Place of Presentation
      横浜
    • Year and Date
      2007-10-03
    • Data Source
      KAKENHI-PROJECT-19590797
  • 1.  UENO Takato (70176618)
    # of Collaborated Projects: 4 results
    # of Collaborated Products: 4 results
  • 2.  TORIMURA Takuji (60197986)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 3.  FUKUI Yoshinori (60243961)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 4.  SASAZUKI Takehiko (50014121)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 5.  KOGA Hironori (90268855)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 6.  NAKAYAMA Hitomi (20368955)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 3 results
  • 7.  MATSUMOTO Tomoaki (30128318)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 8.  INOUE Kaoru (00106113)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 9.  YAMAMOTO Ken (60274528)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 10.  SAKATA Ryuichiro (70258424)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 11.  NAKAMURA Toru (30341332)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 12.  白澤 専二 (10253535)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 13.  木村 利奈 (60299518)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 14.  川口 巧 (00320177)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results

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