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Miyatake Hideyuki  宮武 秀行

… Alternative Names

MIYATAKE Hideyuki  宮武 秀行

宮武 秀行  ミヤタケ ヒデユキ

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Researcher Number 50291935
Other IDs
  • ORCIDhttps://orcid.org/0000-0001-8872-9784
Affiliation (Current) 2025: 国立研究開発法人理化学研究所, 脳神経科学研究センター, 専任研究員
Affiliation (based on the past Project Information) *help 2025: 国立研究開発法人理化学研究所, 脳神経科学研究センター, 専任研究員
2018 – 2023: 国立研究開発法人理化学研究所, 開拓研究本部, 専任研究員
2015 – 2017: 国立研究開発法人理化学研究所, 伊藤ナノ医工学研究室, 専任研究員
2015: 国立研究開発法人理化学研究所, その他部局等, 研究員
2013: 独立行政法人理化学研究所, 連携支援ユニット, 専任研究員 … More
2012: 独立行政法人理化学研究所, バイオ解析チーム, 専任研究員
2006: 独立行政法人理化学研究所, バイオ解析チーム, 先任研究員
2005: 独立行政法人理化学研究所, 三木生物超分子結晶学研究室, 先任研究員
2004: 独立行政法人理化学研究所, 三木生物超分子結晶学研究室, 研究員
2002: 理化学研究所, 播磨研究所, 研究員
2001 – 2002: 理化学研究所, 理論構造生物学研究室, 研究員 Less
Review Section/Research Field
Principal Investigator
Basic Section 43020:Structural biochemistry-related / Microdevices/Nanodevices / Bioinformatics/Life informatics / Nano/Microsystems / Functional biochemistry
Except Principal Investigator
Basic Section 55010:General surgery and pediatric surgery-related / Medium-sized Section 90:Biomedical engineering and related fields / Physical chemistry / Biomedical engineering/Biomaterial science and engineering / Biophysics
Keywords
Principal Investigator
X線結晶構造解析 / 転写制御因子 / 結晶構造 / 2成分系 / in silico/ in vivo 複合選択法 / 人工抗体 / T細胞再活性化活性 / タンパク質工学 / 非IgG人工抗体 / オプジーボ (Nivolumab) … More / in-cell分子相互作用アッセイ / in-silico変異実験 / Rheb / PD1/PD-L1 / コンピュータ創薬 / in silico/in cell選択 / 細胞内ルシフェラーぜアッセイ / in-silico創薬 / mTORC1 / オプジーボ / 非IgG抗体 / in silico/in cell選択法 / 低分子化合物 / ラパマイシン / キナーゼ阻害剤 / mTOR / 免疫チェックポイント阻害剤 / 抗がん剤 / in-silicoスクリーニング / 低分子阻害剤 / 人工抗体タンパク質 / PD-1/PD-L1 / 免疫チェックポイント / タンパク質分子分散制御 / タンパク質分子会合制御 / タンパク質結晶化 / ナノ会合制御 / タンパク質結晶化装置 / タンパク質結晶 / ヒスチジンキナーゼ / 2成分環境応答系システム / レスポンスレギュレータ / センサーキナーゼ … More
Except Principal Investigator
進化分子工学 / 低分子医薬 / がん幹細胞性 / 上皮間葉系移行 / SPFED2 / 低分子医療 / Spred2 / 炎症とがん / シグナル伝達・抑制 / オートファジー / がん / ERK-MAPK / SPRED2 / 微小腫瘍環境 / がん肝細胞性 / 上皮間葉移行 / 内因性抑制因子 / シグナル伝達 / 中分子量医薬 / 金ナノ粒子 / 高分子化 / 多価リガンド化 / 低分子阻害剤 / PD-1 / 高分子効果 / 免疫療法 / 癌治療 / Click反応 / 多価効果 / 高分子医薬 / ペプチド医薬 / 免疫チェックポイント阻害剤 / 中分子医薬 / レーザー分光法 / 変異体作製 / 発光メカニズム / 結晶構造解析 / 水素結合 / 立体効果 / 緑色蛍光タンパク質 / 黄色蛍光タンパク質 / 蛍光メカニズム / 蛍光寿命 / X線結晶構造解析 / 時間分解蛍光分光法 / 蛍光タンパク質 / 医工学 / 蛍光性ペプチド / 生体材料 / 非天然アミノ酸 / ドラッグデリバリー / 蛍光発生プローブ / 生体機能利用 / バイオテクノロジー / ナノバイオ / 分子認識 / 生物・生体工学 / ドッキング・シミュレーション / 葉酸レセプター / インフルエンザ / バイオマーカー / ドラッグ・デリバリーシステム / 分子認識ペプチド / ナノメディシン / ドラッグデリバリーシステム / 中分子創薬 / 電気化学プローブ / 蛍光プローブ / ペプチドアプタマー / Xe / SPring-8 / K吸収端 / I / Cs / ニワトリ卵白リゾチーム / 多波長異常分散法 / 高エネルギーX線 Less
  • Research Projects

    (11 results)
  • Research Products

    (24 results)
  • Co-Researchers

    (13 People)
  •  AI創薬と構造生物学の融合による、アルツハイマー病型タウ線維を分解する化合物の開発Principal Investigator

    • Principal Investigator
      宮武 秀行
    • Project Period (FY)
      2025 – 2027
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 43020:Structural biochemistry-related
    • Research Institution
      Institute of Physical and Chemical Research
  •  Role of Spred2 in the pathogenesis of cancer and its application for cancer thepapy

    • Principal Investigator
      MATSUKAWA AKIHIRO
    • Project Period (FY)
      2021 – 2023
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Review Section
      Basic Section 55010:General surgery and pediatric surgery-related
    • Research Institution
      Okayama University
  •  Rapid design and preparation of artificial antibodies to inhibit immune checkpointsPrincipal Investigator

    • Principal Investigator
      Miyatake Hideyuki
    • Project Period (FY)
      2020 – 2023
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 43020:Structural biochemistry-related
    • Research Institution
      Institute of Physical and Chemical Research
  •  Development of polymeric immune checkpoint inhibitor by extension of low molecular weight compound

    • Principal Investigator
      Ito Yoshihiro
    • Project Period (FY)
      2019 – 2021
    • Research Category
      Grant-in-Aid for Challenging Research (Pioneering)
    • Review Section
      Medium-sized Section 90:Biomedical engineering and related fields
    • Research Institution
      Institute of Physical and Chemical Research
  •  Correlation between the fluorescence lifetime and the local environment of the chromophore: Universal nature to fluorescent proteins from the jellyfish Aequorea Victoria

    • Principal Investigator
      HOSOI Haruko
    • Project Period (FY)
      2017 – 2020
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Physical chemistry
    • Research Institution
      Toho University
  •  マイクロチップを利用した、タンパク質結晶化装置の開発Principal Investigator

    • Principal Investigator
      宮武 秀行
    • Project Period (FY)
      2015 – 2017
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Nano/Microsystems
    • Research Institution
      Institute of Physical and Chemical Research
  •  Creation of molecular recognition peptides for therapy and diagnosis by evolutionary molecular engineering

    • Principal Investigator
      Ito Yoshihiro
    • Project Period (FY)
      2015 – 2017
    • Research Category
      Grant-in-Aid for Scientific Research (A)
    • Research Field
      Biomedical engineering/Biomaterial science and engineering
    • Research Institution
      Institute of Physical and Chemical Research
  •  Development of aggregation control protein crystallization apparatusPrincipal Investigator

    • Principal Investigator
      MIYATAKE Hideyuki
    • Project Period (FY)
      2012 – 2013
    • Research Category
      Grant-in-Aid for Challenging Exploratory Research
    • Research Field
      Microdevices/Nanodevices
    • Research Institution
      Institute of Physical and Chemical Research
  •  構造システム生物学を指向した高度好熱菌の環境応答機構の研究Principal Investigator

    • Principal Investigator
      宮武 秀行
    • Project Period (FY)
      2004 – 2006
    • Research Category
      Grant-in-Aid for Young Scientists (B)
    • Research Field
      Bioinformatics/Life informatics
    • Research Institution
      The Institute of Physical and Chemical Research
  •  高エネルギーX線によるXe,Csを用いた多波長異常分散(MAD)法

    • Principal Investigator
      三木 邦夫
    • Project Period (FY)
      2002
    • Research Category
      Grant-in-Aid for Exploratory Research
    • Research Field
      Biophysics
    • Research Institution
      Kyoto University
  •  センサーキナーゼに共通する制御機構の研究Principal Investigator

    • Principal Investigator
      宮武 秀行
    • Project Period (FY)
      2001 – 2002
    • Research Category
      Grant-in-Aid for Young Scientists (B)
    • Research Field
      Functional biochemistry
    • Research Institution
      The Institute of Physical and Chemical Research

All 2023 2022 2021 2020 2019 2018 2017 2013 2012

All Journal Article Presentation Patent

  • [Journal Article] Mapping of mTOR drug targets: Featured platforms for anti-cancer drug discovery2022

    • Author(s)
      Shams Raef、Ito Yoshihiro、Miyatake Hideyuki
    • Journal Title

      Pharmacology&Therapeutics

      Volume: 232 Pages: 108012-108012

    • DOI

      10.1016/j.pharmthera.2021.108012

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20K06516
  • [Journal Article] Development of an RHEB-Targeting Peptide To Inhibit mTORC1 Kinase Activity2022

    • Author(s)
      Shams Raef、Ito Yoshihiro、Miyatake Hideyuki
    • Journal Title

      ACS Omega

      Volume: 7 Issue: 27 Pages: 23479-23486

    • DOI

      10.1021/acsomega.2c01865

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-20K06516
  • [Journal Article] Evaluation of the Binding Kinetics of RHEB with mTORC1 by In-Cell and In Vitro Assays2021

    • Author(s)
      Shams Raef、Ito Yoshihiro、Miyatake Hideyuki
    • Journal Title

      International Journal of Molecular Sciences

      Volume: 22 Issue: 16 Pages: 8766-8766

    • DOI

      10.3390/ijms22168766

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-20K06516
  • [Journal Article] In Silico and In Cell Hybrid Selection of Nonrapalog Ligands to Allosterically Inhibit the Kinase Activity of mTORC12021

    • Author(s)
      Shams Raef、Matsukawa Akihiro、Ochi Yukari、Ito Yoshihiro、Miyatake Hideyuki
    • Journal Title

      Journal of Medicinal Chemistry

      Volume: 65 Issue: 2 Pages: 1329-1341

    • DOI

      10.1021/acs.jmedchem.1c00536

    • Peer Reviewed / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-20K06516
  • [Journal Article] Development of a Non-IgG PD-1/PD-L1 Inhibitor by in Silico Mutagenesis and an In-Cell Protein-Protein Interaction Asasy2021

    • Author(s)
      Boyang Ning, Xueli Ren, Kyoji Hagiwara, Shinji Takeoka, Yoshihiro Ito, and Hideyuki Miyatake
    • Journal Title

      ACS Chemical Biology

      Volume: 16(2) Issue: 2 Pages: 316-323

    • DOI

      10.1021/acschembio.0c00817

    • Peer Reviewed / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-20K06516
  • [Journal Article] Preparation of Biphenyl-Conjugated Bromotyrosine for Inhibition of PD-1/PD-L1 Immune Checkpoint Interactions2020

    • Author(s)
      Eun-Hye Kim, Masuki Kawamoto, Roopa Dharmatti,Eiry Kobatake,Yoshihiro Ito, Hideyuki Miyatake
    • Journal Title

      Int. J. Mol. Sci.

      Volume: 21 Issue: 10 Pages: 3639-3639

    • DOI

      10.3390/ijms21103639

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-20K20490
  • [Journal Article] Escherichia coli expression, purification, and refolding of human folate receptor α (hFRα) and β (hFRβ)2018

    • Author(s)
      Dharmatti Roopa、Miyatake Hideyuki、Zhang Chen、Ren Xueli、Yumoto Akiko、Kiga Daisuke、Yamamura Masayuki、Ito Yoshihiro
    • Journal Title

      Protein Expression and Purification

      Volume: 印刷中 Pages: 17-22

    • DOI

      10.1016/j.pep.2018.04.006

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-15H01810, KAKENHI-PROJECT-18K19309
  • [Journal Article] Real-Time Control of Nanoscale Protein Assembly for Further Crystallization Using a Solution Circulating Nanoaggregation Control Apparatus2012

    • Author(s)
      Miyatake, H,et al
    • Journal Title

      Crystal Growth & Design

      Volume: 12 Issue: 9 Pages: 4466-4477

    • DOI

      10.1021/cg300619d

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-24651164
  • [Patent] 新規なmTORC1阻害作用を有する化合物を含む、制癌剤、発 がん抑制剤および寿命延長剤2023

    • Inventor(s)
      宮武秀行、他
    • Industrial Property Rights Holder
      宮武秀行、他
    • Industrial Property Rights Type
      特許
    • Filing Date
      2023
    • Data Source
      KAKENHI-PROJECT-20K06516
  • [Patent] 5.新規なmTORC1阻害作用を有する化合物を含む、制癌剤、発がん抑制剤および寿命延長剤2021

    • Inventor(s)
      宮武秀行、伊藤嘉浩、Raef Shams、松川 昭博
    • Industrial Property Rights Holder
      宮武秀行、伊藤嘉浩、Raef Shams、松川 昭博
    • Industrial Property Rights Type
      特許
    • Filing Date
      2021
    • Overseas
    • Data Source
      KAKENHI-PROJECT-20K06516
  • [Patent] 新規なmTORC1阻害作用を有する化合物を含む、制癌剤、発がん抑制剤および寿命延長剤2020

    • Inventor(s)
      宮武秀行
    • Industrial Property Rights Holder
      宮武秀行
    • Industrial Property Rights Type
      特許
    • Industrial Property Number
      2020-160450
    • Filing Date
      2020
    • Data Source
      KAKENHI-PROJECT-20K06516
  • [Presentation] mTORC1のキナーゼ活性をアロステリックに阻害する非ラパログリガンドのin silicoおよびin cellハイブリッド選択2023

    • Author(s)
      Shams Raef, 松川 昭博, 越智 由香里, 伊藤 嘉浩, 宮武 秀行
    • Organizer
      日本生化学会
    • Data Source
      KAKENHI-PROJECT-20K06516
  • [Presentation] 蛍光タンパク質の蛍光寿命の制御2019

    • Author(s)
      坪田 空樹, 間 紗希子, 山口 佳那子, 宮武 秀行, 内田 朗, 細井 晴子
    • Organizer
      分子科学討論会
    • Data Source
      KAKENHI-PROJECT-17K05764
  • [Presentation] 蛍光タンパク質eYFPとそのY145変異体の蛍光寿命に与える発色団周辺環境の影響2017

    • Author(s)
      間 紗希子・宮武 秀行・内田 朗・細井 晴子
    • Organizer
      第11回分子科学討論会
    • Data Source
      KAKENHI-PROJECT-17K05764
  • [Presentation] 新手法を用いたマイクロフロー型自動タンパク質結晶化システムの紹介2013

    • Author(s)
      宮武秀行
    • Organizer
      日本薬学会年会
    • Place of Presentation
      パシフィコ横浜
    • Data Source
      KAKENHI-PROJECT-24651164
  • [Presentation] Development of a DLS-based protein crystallization apparatus2013

    • Author(s)
      Miyatake, H.
    • Organizer
      46th Erice coursae
    • Place of Presentation
      Erice, Italy
    • Data Source
      KAKENHI-PROJECT-24651164
  • [Presentation] Real-time control of protein aggregation for further rational crystallization2013

    • Author(s)
      Hideyuki Miyatake, Tomohiro Yano, Ryo Shiroma, Nobuo Fukumoto, Kazuki Matsumoto, Masahide Kobayashi, Shin Maezawa, Naohiro Kuriyama
    • Organizer
      ICSG2013-SLS
    • Place of Presentation
      Sapporo, Japan
    • Data Source
      KAKENHI-PROJECT-24651164
  • [Presentation] Real-time control of protein aggregation for further rational crystalization2013

    • Author(s)
      Hideyuki Miyatake*, Tomohiro Yano, Ryo Shiroma, Nobuo Fukumoto2, Kazuki Matsumoto, Masahide Kobayashi, Shin Maezawa, Naohiro Kuriyama
    • Organizer
      ICSG2013-SLS
    • Place of Presentation
      Sappolo, Japan
    • Data Source
      KAKENHI-PROJECT-24651164
  • [Presentation] Protein crystallization by real-time controlling of solution composition2013

    • Author(s)
      Hideyuki Miyatake*, Tomohiro Yano, Ryo Shiroma, Nobuo Fukumoto2, Kazuki Matsumoto, Masahide Kobayashi, Shin Maezawa, Naohiro Kuriyama
    • Organizer
      第86回 日本生化学大会
    • Place of Presentation
      パシフィコ横浜、日本
    • Data Source
      KAKENHI-PROJECT-24651164
  • [Presentation] Protein crystallization by real-time controlling of solution composition2013

    • Author(s)
      Hideyuki Miyatake, Tomohiro Yano, Ryo Shiroma, Nobuo Fukumoto, Kazuki Matsumoto, Masahide Kobayashi, Shin Maezawa, Naohiro Kuriyama
    • Organizer
      第86回日本生化学会
    • Place of Presentation
      パシフィコ横浜、日本
    • Data Source
      KAKENHI-PROJECT-24651164
  • [Presentation] Development of a DLS-based protein crystallization apparatus2013

    • Author(s)
      Miyatake, H
    • Organizer
      46th Erice Course
    • Place of Presentation
      Erice, Italy
    • Data Source
      KAKENHI-PROJECT-24651164
  • [Presentation] マイクロフロー型タンパク質自動結晶化システム2012

    • Author(s)
      宮武秀行
    • Organizer
      JASIS 2012
    • Place of Presentation
      幕張メッセ
    • Data Source
      KAKENHI-PROJECT-24651164
  • [Presentation] Development of a DLS-based solution circulating crystallization apparatus2012

    • Author(s)
      Miyatake, H.
    • Organizer
      ICCBM14
    • Place of Presentation
      USA, Huntsville AL
    • Data Source
      KAKENHI-PROJECT-24651164
  • [Presentation] マイクロリアクターを用いた、新規タンパク質結晶化装置の開発2012

    • Author(s)
      宮武秀行
    • Organizer
      京都大学マクロ化学生産研究コンソーシアム
    • Place of Presentation
      京大・桂キャンパス
    • Invited
    • Data Source
      KAKENHI-PROJECT-24651164
  • 1.  Ito Yoshihiro (40192497)
    # of Collaborated Projects: 3 results
    # of Collaborated Products: 2 results
  • 2.  HOSOI Haruko (00313396)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 2 results
  • 3.  MATSUKAWA AKIHIRO (90264283)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 4.  三木 邦夫 (10116105)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 5.  竹田 一旗 (30332290)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 6.  喜田 昭子 (70273430)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 7.  上田 一樹 (10615040)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 8.  多田 誠一 (30598165)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 9.  植木 雅志 (90312264)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 10.  内田 朗 (30176680)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 2 results
  • 11.  秋元 淳 (80649682)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 12.  吉村 禎造 (50174991)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 13.  阪口 政清 (70379840)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results

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