Miyatake Hideyuki 宮武秀行

… Alternative Names

MIYATAKE Hideyuki 宮武秀行

宮武秀行ミヤタケヒデユキ

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Researcher Number	50291935
Other IDs	https://orcid.org/0000-0001-8872-9784
Affiliation (Current)	2025: 国立研究開発法人理化学研究所, 脳神経科学研究センター, 専任研究員
Affiliation (based on the past Project Information) *help	2025: 国立研究開発法人理化学研究所, 脳神経科学研究センター, 専任研究員 2018 – 2023: 国立研究開発法人理化学研究所, 開拓研究本部, 専任研究員 2015 – 2017: 国立研究開発法人理化学研究所, 伊藤ナノ医工学研究室, 専任研究員 2015: 国立研究開発法人理化学研究所, その他部局等, 研究員 2013: 独立行政法人理化学研究所, 連携支援ユニット, 専任研究員 … More 2012: 独立行政法人理化学研究所, バイオ解析チーム, 専任研究員 2006: 独立行政法人理化学研究所, バイオ解析チーム, 先任研究員 2005: 独立行政法人理化学研究所, 三木生物超分子結晶学研究室, 先任研究員 2004: 独立行政法人理化学研究所, 三木生物超分子結晶学研究室, 研究員 2002: 理化学研究所, 播磨研究所, 研究員 2001 – 2002: 理化学研究所, 理論構造生物学研究室, 研究員 Less
Review Section/Research Field	Principal Investigator Basic Section 43020:Structural biochemistry-related / Microdevices/Nanodevices / Bioinformatics/Life informatics / Nano/Microsystems / Functional biochemistry Except Principal Investigator Basic Section 55010:General surgery and pediatric surgery-related / Medium-sized Section 90:Biomedical engineering and related fields / Physical chemistry / Biomedical engineering/Biomaterial science and engineering / Biophysics
Keywords	Principal Investigator X線結晶構造解析 / 転写制御因子 / 結晶構造 / 2成分系 / AI創薬 / cryo EM / in silico screening / AD tau / in silico/ in vivo 複合選択法 / 人工抗体 … More / T細胞再活性化活性 / タンパク質工学 / 非IgG人工抗体 / オプジーボ (Nivolumab) / in-cell分子相互作用アッセイ / in-silico変異実験 / Rheb / PD1/PD-L1 / コンピュータ創薬 / in silico/in cell選択 / 細胞内ルシフェラーぜアッセイ / in-silico創薬 / mTORC1 / オプジーボ / 非IgG抗体 / in silico/in cell選択法 / 低分子化合物 / ラパマイシン / キナーゼ阻害剤 / mTOR / 免疫チェックポイント阻害剤 / 抗がん剤 / in-silicoスクリーニング / 低分子阻害剤 / 人工抗体タンパク質 / PD-1/PD-L1 / 免疫チェックポイント / タンパク質分子分散制御 / タンパク質分子会合制御 / タンパク質結晶化 / ナノ会合制御 / タンパク質結晶化装置 / タンパク質結晶 / ヒスチジンキナーゼ / 2成分環境応答系システム / レスポンスレギュレータ / センサーキナーゼ … More Except Principal Investigator 進化分子工学 / 低分子医薬 / がん幹細胞性 / 上皮間葉系移行 / SPFED2 / 低分子医療 / Spred2 / 炎症とがん / シグナル伝達・抑制 / オートファジー / がん / ERK-MAPK / SPRED2 / 微小腫瘍環境 / がん肝細胞性 / 上皮間葉移行 / 内因性抑制因子 / シグナル伝達 / 中分子量医薬 / 金ナノ粒子 / 高分子化 / 多価リガンド化 / 低分子阻害剤 / PD-1 / 高分子効果 / 免疫療法 / 癌治療 / Click反応 / 多価効果 / 高分子医薬 / ペプチド医薬 / 免疫チェックポイント阻害剤 / 中分子医薬 / レーザー分光法 / 変異体作製 / 発光メカニズム / 結晶構造解析 / 水素結合 / 立体効果 / 緑色蛍光タンパク質 / 黄色蛍光タンパク質 / 蛍光メカニズム / 蛍光寿命 / X線結晶構造解析 / 時間分解蛍光分光法 / 蛍光タンパク質 / 医工学 / 蛍光性ペプチド / 生体材料 / 非天然アミノ酸 / ドラッグデリバリー / 蛍光発生プローブ / 生体機能利用 / バイオテクノロジー / ナノバイオ / 分子認識 / 生物・生体工学 / ドッキング・シミュレーション / 葉酸レセプター / インフルエンザ / バイオマーカー / ドラッグ・デリバリーシステム / 分子認識ペプチド / ナノメディシン / ドラッグデリバリーシステム / 中分子創薬 / 電気化学プローブ / 蛍光プローブ / ペプチドアプタマー / Xe / SPring-8 / K吸収端 / I / Cs / ニワトリ卵白リゾチーム / 多波長異常分散法 / 高エネルギーX線 Less

Development of small molecule drugs to disaggregate Alzheimer's Disease tau filament through integration of AI and structural biologyPrincipal Investigator
- Principal Investigator
  
  宮武秀行
- Project Period (FY)
  2025 – 2027
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 43020:Structural biochemistry-related
- Research Institution
  Institute of Physical and Chemical Research
Role of Spred2 in the pathogenesis of cancer and its application for cancer thepapy
- Principal Investigator
  
  MATSUKAWA AKIHIRO
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 55010:General surgery and pediatric surgery-related
- Research Institution
  Okayama University
Rapid design and preparation of artificial antibodies to inhibit immune checkpointsPrincipal Investigator
- Principal Investigator
  
  Miyatake Hideyuki
- Project Period (FY)
  2020 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 43020:Structural biochemistry-related
- Research Institution
  Institute of Physical and Chemical Research
Development of polymeric immune checkpoint inhibitor by extension of low molecular weight compound
- Principal Investigator
  
  Ito Yoshihiro
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Challenging Research (Pioneering)
- Review Section
  
  Medium-sized Section 90:Biomedical engineering and related fields
- Research Institution
  Institute of Physical and Chemical Research
Correlation between the fluorescence lifetime and the local environment of the chromophore: Universal nature to fluorescent proteins from the jellyfish Aequorea Victoria
- Principal Investigator
  
  HOSOI Haruko
- Project Period (FY)
  2017 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Physical chemistry
- Research Institution
  Toho University
マイクロチップを利用した、タンパク質結晶化装置の開発Principal Investigator
- Principal Investigator
  
  宮武秀行
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Nano/Microsystems
- Research Institution
  Institute of Physical and Chemical Research
Creation of molecular recognition peptides for therapy and diagnosis by evolutionary molecular engineering
- Principal Investigator
  
  Ito Yoshihiro
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  Biomedical engineering/Biomaterial science and engineering
- Research Institution
  Institute of Physical and Chemical Research
Development of aggregation control protein crystallization apparatusPrincipal Investigator
- Principal Investigator
  
  MIYATAKE Hideyuki
- Project Period (FY)
  2012 – 2013
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Microdevices/Nanodevices
- Research Institution
  Institute of Physical and Chemical Research
構造システム生物学を指向した高度好熱菌の環境応答機構の研究Principal Investigator
- Principal Investigator
  
  宮武秀行
- Project Period (FY)
  2004 – 2006
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Bioinformatics/Life informatics
- Research Institution
  The Institute of Physical and Chemical Research
高エネルギーX線によるXe,Csを用いた多波長異常分散(MAD)法
- Principal Investigator
  
  三木邦夫
- Project Period (FY)
  2002
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  Biophysics
- Research Institution
  Kyoto University
センサーキナーゼに共通する制御機構の研究Principal Investigator
- Principal Investigator
  
  宮武秀行
- Project Period (FY)
  2001 – 2002
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Functional biochemistry
- Research Institution
  The Institute of Physical and Chemical Research

All 2023 2022 2021 2020 2019 2018 2017 2013 2012

All Journal Article Presentation Patent

[Journal Article] Mapping of mTOR drug targets: Featured platforms for anti-cancer drug discovery2022
- Author(s)
  Shams Raef、Ito Yoshihiro、Miyatake Hideyuki
- Journal Title
  
  Pharmacology&Therapeutics
  
  Volume: 232 Pages: 108012-108012
- DOI
  10.1016/j.pharmthera.2021.108012
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20K06516
[Journal Article] Development of an RHEB-Targeting Peptide To Inhibit mTORC1 Kinase Activity2022
- Author(s)
  Shams Raef、Ito Yoshihiro、Miyatake Hideyuki
- Journal Title
  
  ACS Omega
  
  Volume: 7 Issue: 27 Pages: 23479-23486
- DOI
  10.1021/acsomega.2c01865
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K06516
[Journal Article] Evaluation of the Binding Kinetics of RHEB with mTORC1 by In-Cell and In Vitro Assays2021
- Author(s)
  Shams Raef、Ito Yoshihiro、Miyatake Hideyuki
- Journal Title
  
  International Journal of Molecular Sciences
  
  Volume: 22 Issue: 16 Pages: 8766-8766
- DOI
  10.3390/ijms22168766
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K06516
[Journal Article] In Silico and In Cell Hybrid Selection of Nonrapalog Ligands to Allosterically Inhibit the Kinase Activity of mTORC12021
- Author(s)
  Shams Raef、Matsukawa Akihiro、Ochi Yukari、Ito Yoshihiro、Miyatake Hideyuki
- Journal Title
  
  Journal of Medicinal Chemistry
  
  Volume: 65 Issue: 2 Pages: 1329-1341
- DOI
  10.1021/acs.jmedchem.1c00536
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K06516
[Journal Article] Development of a Non-IgG PD-1/PD-L1 Inhibitor by in Silico Mutagenesis and an In-Cell Protein-Protein Interaction Asasy2021
- Author(s)
  Boyang Ning, Xueli Ren, Kyoji Hagiwara, Shinji Takeoka, Yoshihiro Ito, and Hideyuki Miyatake
- Journal Title
  
  ACS Chemical Biology
  
  Volume: 16(2) Issue: 2 Pages: 316-323
- DOI
  10.1021/acschembio.0c00817
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K06516
[Journal Article] Preparation of Biphenyl-Conjugated Bromotyrosine for Inhibition of PD-1/PD-L1 Immune Checkpoint Interactions2020
- Author(s)
  Eun-Hye Kim, Masuki Kawamoto, Roopa Dharmatti,Eiry Kobatake,Yoshihiro Ito, Hideyuki Miyatake
- Journal Title
  
  Int. J. Mol. Sci.
  
  Volume: 21 Issue: 10 Pages: 3639-3639
- DOI
  10.3390/ijms21103639
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K20490
[Journal Article] Escherichia coli expression, purification, and refolding of human folate receptor α (hFRα) and β (hFRβ)2018
- Author(s)
  Dharmatti Roopa、Miyatake Hideyuki、Zhang Chen、Ren Xueli、Yumoto Akiko、Kiga Daisuke、Yamamura Masayuki、Ito Yoshihiro
- Journal Title
  
  Protein Expression and Purification
  
  Volume: 印刷中 Pages: 17-22
- DOI
  10.1016/j.pep.2018.04.006
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15H01810, KAKENHI-PROJECT-18K19309
[Journal Article] Real-Time Control of Nanoscale Protein Assembly for Further Crystallization Using a Solution Circulating Nanoaggregation Control Apparatus2012
- Author(s)
  Miyatake, H,et al
- Journal Title
  
  Crystal Growth & Design
  
  Volume: 12 Issue: 9 Pages: 4466-4477
- DOI
  10.1021/cg300619d
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24651164
[Patent] 新規なｍＴＯＲＣ１阻害作用を有する化合物を含む、制癌剤、発がん抑制剤および寿命延長剤2023
- Inventor(s)
  宮武秀行、他
- Industrial Property Rights Holder
  宮武秀行、他
- Industrial Property Rights Type
  特許
- Filing Date
  2023
- Data Source
  KAKENHI-PROJECT-20K06516
[Patent] ５．新規なmTORC1阻害作用を有する化合物を含む、制癌剤、発がん抑制剤および寿命延長剤2021
- Inventor(s)
  宮武秀行、伊藤嘉浩、Raef Shams、松川　昭博
- Industrial Property Rights Holder
  宮武秀行、伊藤嘉浩、Raef Shams、松川　昭博
- Industrial Property Rights Type
  特許
- Filing Date
  2021
- Overseas
- Data Source
  KAKENHI-PROJECT-20K06516
[Patent] 新規なmTORC1阻害作用を有する化合物を含む、制癌剤、発がん抑制剤および寿命延長剤2020
- Inventor(s)
  宮武秀行
- Industrial Property Rights Holder
  宮武秀行
- Industrial Property Rights Type
  特許
- Industrial Property Number
  2020-160450
- Filing Date
  2020
- Data Source
  KAKENHI-PROJECT-20K06516
[Presentation] mTORC1のキナーゼ活性をアロステリックに阻害する非ラパログリガンドのin silicoおよびin cellハイブリッド選択2023
- Author(s)
  Shams Raef, 松川昭博, 越智由香里, 伊藤嘉浩, 宮武秀行
- Organizer
  日本生化学会
- Data Source
  KAKENHI-PROJECT-20K06516
[Presentation] 蛍光タンパク質の蛍光寿命の制御2019
- Author(s)
  坪田空樹, 間紗希子, 山口佳那子, 宮武秀行, 内田朗, 細井晴子
- Organizer
  分子科学討論会
- Data Source
  KAKENHI-PROJECT-17K05764
[Presentation] 蛍光タンパク質eYFPとそのY145変異体の蛍光寿命に与える発色団周辺環境の影響2017
- Author(s)
  間紗希子・宮武秀行・内田朗・細井晴子
- Organizer
  第11回分子科学討論会
- Data Source
  KAKENHI-PROJECT-17K05764
[Presentation] 新手法を用いたマイクロフロー型自動タンパク質結晶化システムの紹介2013
- Author(s)
  宮武秀行
- Organizer
  日本薬学会年会
- Place of Presentation
  パシフィコ横浜
- Data Source
  KAKENHI-PROJECT-24651164
[Presentation] Development of a DLS-based protein crystallization apparatus2013
- Author(s)
  Miyatake, H.
- Organizer
  46th Erice coursae
- Place of Presentation
  Erice, Italy
- Data Source
  KAKENHI-PROJECT-24651164
[Presentation] Real-time control of protein aggregation for further rational crystallization2013
- Author(s)
  Hideyuki Miyatake, Tomohiro Yano, Ryo Shiroma, Nobuo Fukumoto, Kazuki Matsumoto, Masahide Kobayashi, Shin Maezawa, Naohiro Kuriyama
- Organizer
  ICSG2013-SLS
- Place of Presentation
  Sapporo, Japan
- Data Source
  KAKENHI-PROJECT-24651164
[Presentation] Real-time control of protein aggregation for further rational crystalization2013
- Author(s)
  Hideyuki Miyatake*, Tomohiro Yano, Ryo Shiroma, Nobuo Fukumoto2, Kazuki Matsumoto, Masahide Kobayashi, Shin Maezawa, Naohiro Kuriyama
- Organizer
  ICSG2013-SLS
- Place of Presentation
  Sappolo, Japan
- Data Source
  KAKENHI-PROJECT-24651164
[Presentation] Protein crystallization by real-time controlling of solution composition2013
- Author(s)
  Hideyuki Miyatake*, Tomohiro Yano, Ryo Shiroma, Nobuo Fukumoto2, Kazuki Matsumoto, Masahide Kobayashi, Shin Maezawa, Naohiro Kuriyama
- Organizer
  第86回　日本生化学大会
- Place of Presentation
  パシフィコ横浜、日本
- Data Source
  KAKENHI-PROJECT-24651164
[Presentation] Protein crystallization by real-time controlling of solution composition2013
- Author(s)
  Hideyuki Miyatake, Tomohiro Yano, Ryo Shiroma, Nobuo Fukumoto, Kazuki Matsumoto, Masahide Kobayashi, Shin Maezawa, Naohiro Kuriyama
- Organizer
  第86回日本生化学会
- Place of Presentation
  パシフィコ横浜、日本
- Data Source
  KAKENHI-PROJECT-24651164
[Presentation] Development of a DLS-based protein crystallization apparatus2013
- Author(s)
  Miyatake, H
- Organizer
  46th Erice Course
- Place of Presentation
  Erice, Italy
- Data Source
  KAKENHI-PROJECT-24651164
[Presentation] マイクロフロー型タンパク質自動結晶化システム2012
- Author(s)
  宮武秀行
- Organizer
  JASIS 2012
- Place of Presentation
  幕張メッセ
- Data Source
  KAKENHI-PROJECT-24651164
[Presentation] Development of a DLS-based solution circulating crystallization apparatus2012
- Author(s)
  Miyatake, H.
- Organizer
  ICCBM14
- Place of Presentation
  USA, Huntsville AL
- Data Source
  KAKENHI-PROJECT-24651164
[Presentation] マイクロリアクターを用いた、新規タンパク質結晶化装置の開発2012
- Author(s)
  宮武秀行
- Organizer
  京都大学マクロ化学生産研究コンソーシアム
- Place of Presentation
  京大・桂キャンパス
- Invited
- Data Source
  KAKENHI-PROJECT-24651164

1. Ito Yoshihiro (40192497)

# of Collaborated Projects: 3 results

# of Collaborated Products: 2 results
2. HOSOI Haruko (00313396)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
3. MATSUKAWA AKIHIRO (90264283)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
4. 三木邦夫 (10116105)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
5. 竹田一旗 (30332290)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. 喜田昭子 (70273430)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. 上田一樹 (10615040)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. 多田誠一 (30598165)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. 植木雅志 (90312264)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. 内田朗 (30176680)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
11. 秋元淳 (80649682)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
12. 吉村禎造 (50174991)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
13. 阪口政清 (70379840)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results

Miyatake Hideyuki 宮武 秀行

MIYATAKE Hideyuki 宮武 秀行

宮武 秀行 ミヤタケ ヒデユキ

Research Projects

Research Products

Co-Researchers

Development of small molecule drugs to disaggregate Alzheimer's Disease tau filament through integration of AI and structural biologyPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Role of Spred2 in the pathogenesis of cancer and its application for cancer thepapy

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Rapid design and preparation of artificial antibodies to inhibit immune checkpointsPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Development of polymeric immune checkpoint inhibitor by extension of low molecular weight compound

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Correlation between the fluorescence lifetime and the local environment of the chromophore: Universal nature to fluorescent proteins from the jellyfish Aequorea Victoria

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

マイクロチップを利用した、タンパク質結晶化装置の開発Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Creation of molecular recognition peptides for therapy and diagnosis by evolutionary molecular engineering

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Development of aggregation control protein crystallization apparatusPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

構造システム生物学を指向した高度好熱菌の環境応答機構の研究Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

高エネルギーX線によるXe,Csを用いた多波長異常分散(MAD)法

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

センサーキナーゼに共通する制御機構の研究Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Mapping of mTOR drug targets: Featured platforms for anti-cancer drug discovery2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Development of an RHEB-Targeting Peptide To Inhibit mTORC1 Kinase Activity2022

Author(s)

Journal Title

Miyatake Hideyuki 宮武秀行

MIYATAKE Hideyuki 宮武秀行

宮武秀行ミヤタケヒデユキ

[Patent] 新規なｍＴＯＲＣ１阻害作用を有する化合物を含む、制癌剤、発がん抑制剤および寿命延長剤2023