Uchiyama Kazuhiko 内山和彦

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UCHIYAMA Kazuhiko 内山和彦

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Researcher Number	50298428
Other IDs
Affiliation (Current)	2025: 京都府立医科大学, 医学(系)研究科(研究院), 講師
Affiliation (based on the past Project Information) *help	2021 – 2024: 京都府立医科大学, 医学(系)研究科(研究院), 講師 2012 – 2020: 京都府立医科大学, 医学(系)研究科(研究院), 助教 2009 – 2011: Kyoto Prefectural University of Medicine, 医学研究科, 助教
Review Section/Research Field	Principal Investigator Basic Section 44010:Cell biology-related / Pathological medical chemistry / Applied pharmacology / Gastroenterology Except Principal Investigator Basic Section 53010:Gastroenterology-related / Gastroenterology / Basic Section 54020:Connective tissue disease and allergy-related
Keywords	Principal Investigator 潰瘍性大腸炎 / 再燃 / DSS腸炎 / IBD / Wnt5a / Hsp25 / BEST2 / peptide / 炎症性サイトカイン / 粘膜 … More / 抗炎症 / ペプチド / サイトカイン / 炎症性腸疾患 / YAMC細胞 / butyrate / mucosal healing / 創傷治癒 / 粘膜再生 / 短鎖脂肪酸 / 筋繊維芽細胞 / 大腸上皮細胞 / アザチオプリン / Express Genotyping / EAI / SLC38A9 / azathioprine（AZA） / genetic biomarker / 6-TGN / azathioprine / FGF15 / Myofibroblast / SERPINB1 / myofibroblast / クローン病 / Wnt-5a … More Except Principal Investigator 炎症性腸疾患 / 一酸化炭素 / 腸管免疫 / c-di-GMP / Th17 / 腸炎 / 環状ジヌクレオチド / STING / ヘムオキシゲナーゼ / マクロファージ / 腸管炎症 / Heme oxygenase-1 / ペプチドマーカー / 質量分析 / 大腸癌 / バイオマーカー / 関節リウマチ / 腸内環境 / 一酸化炭 / 大腸潰瘍 / 皮膚潰瘍 / 腸内細菌叢 / Paraprevotella / 潰瘍性大腸炎 / Bach1 / Heme Oxygenase-1 / Th17細胞 / 樹状細胞 / 核酸センサー / 体外受精 / リンパ球分化 / Th17リンパ球分化 / ナイーブCD4+ T細胞 / heme oxygenase-1 / Heme oxygenase / リキッドバイオプシー / ペプチド分析 / 先制医療 / 質量分析計 / ペプチド / 早期発見 / 熱ショックタンパク質 / メチルグリオキザール / 腸管粘膜免疫 / SPARC / 翻訳後修飾熱ショック蛋白質 Less

Investigation of the pathogenesis about relapse in ulcerative colitis based on colonic mucosal gene expressionPrincipal Investigator
- Principal Investigator
  
  内山和彦
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 44010:Cell biology-related
- Research Institution
  Kyoto Prefectural University of Medicine
Molecular Mechanism of Carbon Monoxide asa Gaseous Therapeutic Molecule against Intestinal Inflammation
- Principal Investigator
  
  高木智久
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 53010:Gastroenterology-related
- Research Institution
  Kyoto Prefectural University of Medicine
Exploratory research for peptide markers of rheumatoid arthritis
- Principal Investigator
  
  川人豊
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 54020:Connective tissue disease and allergy-related
- Research Institution
  Kyoto Prefectural University of Medicine
Novel strategy for the treatment of inflammatory bowel disease based on adjuvant immunotherapy by cyclic dinucleotides
- Principal Investigator
  
  尾松達司
- Project Period (FY)
  2022 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 53010:Gastroenterology-related
- Research Institution
  Kyoto Prefectural University of Medicine
Heme oxygenase/carbon monoxide-mediated intestinal modulation for the development of gas molecule drugs
- Principal Investigator
  
  Tomohisa Takagi
- Project Period (FY)
  2020 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 53010:Gastroenterology-related
- Research Institution
  Kyoto Prefectural University of Medicine
The effect of Wnt5a derived peptide to reduce intestinal inflammationPrincipal Investigator
- Principal Investigator
  
  Uchiyama Kazuhiko
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 44010:Cell biology-related
- Research Institution
  Kyoto Prefectural University of Medicine
Mechanisms of intestinal inflammation regulation and immune response to cyclic dinucleotides
- Principal Investigator
  
  Omatsu Tatsushi
- Project Period (FY)
  2018 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 53010:Gastroenterology-related
- Research Institution
  Kyoto Prefectural University of Medicine
  Asahi University
Precision Medicine for Colon Cancer by High-throughput Analysis by Quantitative Mass Spectrometry
- Principal Investigator
  
  Naito Yuji
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Gastroenterology
- Research Institution
  Kyoto Prefectural University of Medicine
The development of drug delivery system of carbon monoxide for inflammatory bowel disease
- Principal Investigator
  
  Takagi Tomohisa
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Gastroenterology
- Research Institution
  Kyoto Prefectural University of Medicine
The role of Wnt5a peptide to enhance colonic epithelial healing for the treatment of IBDPrincipal Investigator
- Principal Investigator
  
  Uchiyama Kazuhiko
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Pathological medical chemistry
- Research Institution
  Kyoto Prefectural University of Medicine
Role of Hsp27 and SPARC in the carcinogenesis of colorectal cancer
- Principal Investigator
  
  Naito Yuji
- Project Period (FY)
  2013 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Gastroenterology
- Research Institution
  Kyoto Prefectural University of Medicine
The examination about the usefulness of SLC38A9 as genetic biomarker to predict blood concentration of azathioprine.Principal Investigator
- Principal Investigator
  
  UCHIYAMA Kazuhiko
- Project Period (FY)
  2012 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Applied pharmacology
- Research Institution
  Kyoto Prefectural University of Medicine
The role of Wnt-5a as the pathological marker of inflammatory bowel disease.Principal Investigator
- Principal Investigator
  
  UCHIYAMA Kazuhiko
- Project Period (FY)
  2009 – 2011
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Gastroenterology
- Research Institution
  Kyoto Prefectural University of Medicine

All 2022 2021 2020 2019 2018 2017 2016 2015 2014 2013 2012 2011 2010 2009 Other

All Journal Article Presentation

[Journal Article] Role and Potential Mechanism of Heme Oxygenase-1 in Intestinal Ischemia-Reperfusion Injury.2022
- Author(s)
  Katada K, Takagi T, Iida T, Ueda T, Mizushima K, Fukui A, Okayama T, Kamada K, Uchiyama K, Ishikawa T, Naito Y, Itoh Y.
- Journal Title
  
  Antioxidants.
  
  Volume: 11 Issue: 3 Pages: 559-559
- DOI
  10.3390/antiox11030559
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K08292, KAKENHI-PROJECT-20K08363, KAKENHI-PROJECT-20K11513
[Journal Article] Topical application of sustained released-carbon monoxide promotes cutaneous wound healing in diabetic mice.2022
- Author(s)
  Takagi T, Okayama T, Asai J, Mizushima K, Hirai Y, Uchiyama K, Ishikawa T, Naito Y, Itoh Y.
- Journal Title
  
  Biochem Pharmacol.
  
  Volume: 199 Pages: 115016-115016
- DOI
  10.1016/j.bcp.2022.115016
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20K08292
[Journal Article] Lycopene intake induces colonic regulatory T cells in mice and suppresses food allergy symptoms.2022
- Author(s)
  Ushiroda C, Takagi T, Fuke N, Mizushima K, Hirai Y, Higashimura Y, Harusato A, Kamada K, Uchiyama K, Ishikawa T, Aizawa K, Suganuma H, Itoh Y, Naito Y.
- Journal Title
  
  Pediatr Allergy Immunol.
  
  Volume: 33 Issue: 1
- DOI
  10.1111/pai.13691
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K08292, KAKENHI-PROJECT-21K05471, KAKENHI-PROJECT-20K19672
[Journal Article] Identification of colorectal neoplasia by using serum bile acid profile2021
- Author(s)
  Uchiyama Kazuhiko、Naito Yuji、Yagi Nobuaki、Mizushima Katsura、Higashimura Yasuki、Hirai Yasuko、Dohi Osamu、Okayama Tetsuya、Yoshida Naohisa、Katada Kazuhiro、Kamada Kazuhiro、Ishikawa Takeshi、Takagi Tomohisa、Konishi Hideyuki、Kuriu Yoshiaki、Nakanishi Masayoshi、Otsuji Eigo、Honda Akira、Itoh Yoshito
- Journal Title
  
  Biomarkers
  
  Volume: - Issue: 5 Pages: 1-6
- DOI
  10.1080/1354750x.2021.1917663
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K05475, KAKENHI-PROJECT-18K06224
[Journal Article] The efficacy of linked color imaging for the endoscopic diagnosis of mucosal healing in quiescent ulcerative colitis2021
- Author(s)
  Takagi Tomohisa、Uchiyama Kazuhiko、Kajiwara‐Kubota Mariko、Kashiwagi Saori、Toyokawa Yuki、Hotta Yuma、Tanaka Makoto、Inoue Ken、Dohi Osamu、Yoshida Naohisa、Kamada Kazuhiro、Ishikawa Takeshi、Konishi Hideyuki、Kishimoto Mitsuo、Yagi Nobuaki、Naito Yuji、Itoh Yoshito
- Journal Title
  
  Journal of Gastroenterology and Hepatology
  
  Volume: 12 Issue: 9 Pages: 2448-2454
- DOI
  10.1111/jgh.15489
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K06224
[Journal Article] Therapeutic Potential of Astaxanthin in Diabetic Kidney Disease2021
- Author(s)
  Naito Yuji、Uchiyama Kazuhiko、Handa Osamu、Aoi Wataru
- Journal Title
  
  Advances in Experimental Medicine and Biology
  
  Volume: 1261 Pages: 239-248
- DOI
  10.1007/978-981-15-7360-6_22
- ISBN
  9789811573590, 9789811573606
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K06224
[Journal Article] Low serum albumin at admission is a predictor of early colectomy in patients with moderate to severe ulcerative colitis2021
- Author(s)
  Tanaka Makoto、Takagi Tomohisa、Naito Yuji、Uchiyama Kazuhiko、Hotta Yuma、Toyokawa Yuki、Kashiwagi Saori、Kamada Kazuhiro、Ishikawa Takeshi、Yasuda Hiroaki、Konishi Hideyuki、Itoh Yoshito
- Journal Title
  
  JGH Open
  
  Volume: 5 Issue: 3 Pages: 377-381
- DOI
  10.1002/jgh3.12506
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K06224
[Journal Article] Rectal administration of carbon monoxide inhibits the development of intestinal inflammation and promotes intestinal wound healing via the activation of the Rho-kinase pathway in rats.2021
- Author(s)
  Takagi T, Naito Y, Higashimura Y, Uchiyama K, Okayama T, Mizushima K, Katada K, Kamada K, Ishikawa T, Itoh Y.
- Journal Title
  
  Nitric Oxide.
  
  Volume: 107 Pages: 19-30
- DOI
  10.1016/j.niox.2020.12.006
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20K08292, KAKENHI-PROJECT-18K05475, KAKENHI-PROJECT-18K06224
[Journal Article] Increased mucosal IL-12 expression is associated with relapse of ulcerative colitis2021
- Author(s)
  Uchiyama Kazuhiko、Takagi Tomohisa、Mizushima Katsura、Kajiwara-Kubota Mariko、Kashiwagi Saori、Toyokawa Yuki、Tanaka Makoto、Hotta Yuma、Kamada Kazuhiro、Ishikawa Takeshi、Konishi Hideyuki、Kishimoto Mitsuo、Naito Yuji、Itoh Yoshito
- Journal Title
  
  BMC Gastroenterology
  
  Volume: 21 Issue: 1
- DOI
  10.1186/s12876-021-01709-5
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K06224
[Journal Article] Promotion of wound healing by acetate in murine colonic epithelial cell via c‐Jun N‐terminal kinase activation2020
- Author(s)
  Nakano Takahiro、Uchiyama Kazuhiko、Ushiroda Chihiro、Kashiwagi Saori、Toyokawa Yuki、Mizushima Katsura、Inoue Ken、Dohi Osamu、Okayama Tetsuya、Yoshida Naohisa、Katada Kazuhiro、Kamada Kazuhiro、Handa Osamu、Ishikawa Takeshi、Takagi Tomohisa、Konishi Hideyuki、Naito Yuji、Itoh Yoshito
- Journal Title
  
  Journal of Gastroenterology and Hepatology
  
  Volume: 35 Issue: 7 Pages: 1171-1179
- DOI
  10.1111/jgh.14987
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20K19672, KAKENHI-PROJECT-18K06224
[Journal Article] Changes in the Gut Microbiota are Associated with Hypertension, Hyperlipidemia, and Type 2 Diabetes Mellitus in Japanese Subjects2020
- Author(s)
  Takagi Tomohisa、Naito Yuji、Kashiwagi Saori、Uchiyama Kazuhiko、Mizushima Katsura、Kamada Kazuhiro、Ishikawa Takeshi、Inoue Ryo、Okuda Kayo、Tsujimoto Yoshimasa、Ohnogi Hiromu、Itoh Yoshito
- Journal Title
  
  Nutrients
  
  Volume: 12 Issue: 10 Pages: 2996-2996
- DOI
  10.3390/nu12102996
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K06224
[Journal Article] Trans-unsaturated fatty acid activates NLRP3 inflammasome in macrophages and exacerbates intestinal inflammation in mice2020
- Author(s)
  Higashimura Yasuki、Tanaka Yumiko、Takagi Tomohisa、Uchiyama Kazuhiko、Mizushima Katsura、Niki Etsuo、Naito Yuji
- Journal Title
  
  Biochemical and Biophysical Research Communications
  
  Volume: 529 Issue: 2 Pages: 243-250
- DOI
  10.1016/j.bbrc.2020.06.005
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K05475, KAKENHI-PROJECT-18K06224
[Journal Article] Differences in gut microbiota associated with age, sex, and stool consistency in healthy Japanese subjects.2019
- Author(s)
  Takagi T, Naito Y, Inoue R, Kashiwagi S, Uchiyama K, Mizushima K, Tsuchiya S, Dohi O, Yoshida N, Kamada K, Ishikawa T, Handa O, Konishi H, Okuda K, Tsujimoto Y, Ohnogi H, Itoh Y.
- Journal Title
  
  J Gastroenterol.
  
  Volume: 54 Issue: 1 Pages: 53-63
- DOI
  10.1007/s00535-018-1488-5
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16K09322
[Journal Article] Mucosa-Associated Microbiota in the Gastrointestinal Tract of Healthy Japanese Subjects2019
- Author(s)
  Kashiwagi Saori、Naito Yuji、Inoue Ryo、Takagi Tomohisa、Nakano Takahiro、Inada Yutaka、Fukui Akifumi、Katada Kazuhiro、Mizushima Katsura、Kamada Kazuhiro、Uchiyama Kazuhiko、Handa Osamu、Ishikawa Takeshi、Itoh Yoshito
- Journal Title
  
  Digestion
  
  Volume: 101 Issue: 2 Pages: 107-120
- DOI
  10.1159/000496102
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K06224
[Journal Article] Zinc Deficiency Activates the IL-23/Th17 Axis to Aggravate Experimental Colitis in Mice2019
- Author(s)
  Higashimura Yasuki、Takagi Tomohisa、Naito Yuji、Uchiyama Kazuhiko、Mizushima Katsura、Tanaka Makoto、Hamaguchi Masahide、Itoh Yoshito
- Journal Title
  
  Journal of Crohn's and Colitis
  
  Volume: - Issue: 6 Pages: 856-866
- DOI
  10.1093/ecco-jcc/jjz193
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K05475, KAKENHI-PROJECT-18K06224
[Journal Article] Intestinal microbiome as a novel therapeutic target for local and systemic inflammation2019
- Author(s)
  Uchiyama Kazuhiko、Naito Yuji、Takagi Tomohisa
- Journal Title
  
  Pharmacology & Therapeutics
  
  Volume: 199 Pages: 164-172
- DOI
  10.1016/j.pharmthera.2019.03.006
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K06224
[Journal Article] Elevated ER stress exacerbates dextran sulfate sodium-induced colitis in PRDX4-knockout mice2019
- Author(s)
  Takagi T, Homma T, Fujii J, Shirasawa N, Yoriki H, Hotta Y, Higashimura Y, Mizushima K, Hirai Y, Katada K, Uchiyama K, Naito Y, Itoh Y.
- Journal Title
  
  Free Radical Biology and Medicine
  
  Volume: 134 Pages: 153-164
- DOI
  10.1016/j.freeradbiomed.2018.12.024
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K05475, KAKENHI-PROJECT-18K06948, KAKENHI-PROJECT-16K09322, KAKENHI-PROJECT-18K06224
[Journal Article] Green tea polyphenol (epigallocatechin-3-gallate) improves gut dysbiosis and serum bile acids dysregulation in high-fat diet-fed mice2019
- Author(s)
  Ushiroda Chihiro、Naito Yuji、Takagi Tomohisa、Uchiyama Kazuhiko、Mizushima Katsura、Higashimura Yasuki、Yasukawa Zenta、Okubo Tsutomu、Inoue Ryo、Honda Akira、Matsuzaki Yasushi、Itoh Yoshito
- Journal Title
  
  Journal of Clinical Biochemistry and Nutrition
  
  Volume: 65 Issue: 1 Pages: 34-46
- DOI
  10.3164/jcbn.18-116
- NAID
  130007672107
- ISSN
  0912-0009, 1880-5086
- Language
  English
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K05475, KAKENHI-PROJECT-18K06224
[Journal Article] Carbon monoxide ameliorates murine T-cell dependent colitis through the inhibition of Th17 differentiation.2018
- Author(s)
  Takagi T, Naito Y, Tanaka M, Mizushima K, Ushiroda C, Toyokawa Y, Uchiyama K, Hamaguchi M, Handa O, Itoh Y.
- Journal Title
  
  Free Radic Res
  
  Volume: 印刷中 Issue: 11-12 Pages: 1328-1335
- DOI
  10.1080/10715762.2018.1470327
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16K09322
[Journal Article] Secreted protein acidic and rich in cysteine functions in colitis via IL17A regulation in mucosal CD4(+) T cells.2018
- Author(s)
  Tanaka M, Takagi T, Naito Y, Uchiyama K, Hotta Y, Toyokawa Y, Ushiroda C, Hirai Y, Aoi W, Higashimura Y, Mizushima K, Okayama T, Katada K, Kamada K, Ishikawa T, Handa O, Itoh Y.
- Journal Title
  
  J Gastroenterol Hepatol.
  
  Volume: 33 Issue: 3 Pages: 671-680
- DOI
  10.1111/jgh.13842
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16K09322, KAKENHI-PROJECT-16H05289, KAKENHI-PROJECT-16K16281, KAKENHI-PROJECT-17H02176
[Journal Article] Selected reaction monitoring for colorectal cancer diagnosis using a set of five serum peptides identified by BLOTCHIP((R))-MS analysis2018
- Author(s)
  Uchiyama, K. Naito, Y. Yagi, N. Mizushima, K. Higashimura, Y. Hirai, Y. Dohi, O. Okayama, T. Yoshida, N. Katada, K. Kamada, K. Handa, O. Ishikawa, T. Takagi, T. Konishi, H. Nonaka, D. Asada, K. Lee, L. J. Tanaka, K. Kuriu, Y. Nakanishi, M. Otsuji, E. Itoh, Y.
- Journal Title
  
  J Gastroenterol
  
  Volume: 印刷中 Issue: 11 Pages: 1179-1185
- DOI
  10.1007/s00535-018-1448-0
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H05289, KAKENHI-PROJECT-18K05475, KAKENHI-PROJECT-18K06224
[Journal Article] The protective effect of orally administered redox nanoparticle on intestinal ischemia-reperfusion injury in mice.2018
- Author(s)
  Ueda T, Takagi T, Katada K, Iida T, Mizushima K, Dohi O, Okayama T, Yoshida N, Kamada K, Uchiyama K, Handa O, Ishikawa T, Konishi H, Naito Y, Nagasaki Y, Itoh Y.
- Journal Title
  
  Biochem Biophys Res Commun
  
  Volume: 495 Issue: 2 Pages: 2044-2049
- DOI
  10.1016/j.bbrc.2017.11.204
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K10512, KAKENHI-PROJECT-16H05289, KAKENHI-PROJECT-18H04160
[Journal Article] The influence of long-term use of proton pump inhibitors on the gut microbiota: an age-sex-matched case-control study2018
- Author(s)
  Takagi T, Naito Y, Inoue R, Kashiwagi S, Uchiyama K, Mizushima K, Tsuchiya S, Okayama T, Dohi O, Yoshida N, Kamada K, Ishikawa T, Handa O, Konishi H, Okuda K, Tsujimoto Y, Ohnogi H, Itoh Y.
- Journal Title
  
  Journal of Clinical Biochemistry and Nutrition
  
  Volume: 62 Issue: 1 Pages: 100-105
- DOI
  10.3164/jcbn.17-78
- NAID
  130006301255
- ISSN
  0912-0009, 1880-5086
- Language
  English
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16K09322
[Journal Article] Heme oxygenase-1 prevents murine intestinal inflammation2018
- Author(s)
  Takagi T, Naito Y, Mizushima K, Hirai Y, Harusato A, Okayama T, Katada K, Kamada K, Uchiyama K, Handa O, Ishikawa T, Itoh Y.
- Journal Title
  
  J Clin Biochem Nutr.
  
  Volume: 印刷中
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16K09322
[Journal Article] Heme oxygenase-1 prevents murine intestinal inflammation2018
- Author(s)
  Takagi Tomohisa、Naito Yuji、Mizushima Katsura、Hirai Yasuko、Harusato Akihito、Okayama Tetsuya、Katada Kazhuhiro、Kamada Kazuhiro、Uchiyama Kazuhiko、Handa Osamu、Ishikawa Takeshi、Itoh Yoshito
- Journal Title
  
  Journal of Clinical Biochemistry and Nutrition
  
  Volume: 63 Issue: 3 Pages: 169-174
- DOI
  10.3164/jcbn.17-133
- ISSN
  0912-0009, 1880-5086
- Language
  English
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K15128, KAKENHI-PROJECT-16K09322
[Journal Article] Assessment of endoscopic mucosal healing of ulcerative colitis using linked colour imaging, a novel endoscopic enhancement system2017
- Author(s)
  Kazuhiko Uchiyama, Tomohisa Takagi, Saori Kashiwagi, Yuki Toyokawa, Makoto, Tanaka, Yuma Hotta, Osamu Dohi, Tetsuya Okayama, Naohisa Yoshida, Kazuhiro Katada, Kazuhiro Kamada, Takeshi Ishikawa, Osamu Handa, Hideyuki Konishi, Mitsuo Kishimoto, Nobuaki Yagi, Yuji Naito, Yoshito Itoh
- Journal Title
  
  Journal of Crohn's and Colitis
  
  Volume: 11(8) Issue: 8 Pages: 963-969
- DOI
  10.1093/ecco-jcc/jjx026
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-15K08313
[Journal Article] Serum metabolomics analysis for early detection of colorectal cancer2017
- Author(s)
  Kazuhiko Uchiyama, Nobuaki Yagi, Katsura Mizushima, Yasuki Higashimura, Yasuko Hirai, Tetsuya Okayama, Naohisa Yoshida, Kazuhiro Katada, Kazuhiro Kamada, Osamu Handa, Takeshi Ishikawa, Tomohisa Takagi, Hideyuki Konishi, Yoshiaki Kuriu, Masayoshi Nakanishi, Eigo Otsuji, Yoshito Itoh, Yuji Naito
- Journal Title
  
  Journal of Gastroenterology
  
  Volume: 52(6) Issue: 6 Pages: 677-694
- DOI
  10.1007/s00535-016-1261-6
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-15K08313, KAKENHI-PROJECT-16H05289
[Journal Article] 大腸癌リキッドバイオプシーとしてのメタボローム解析2016
- Author(s)
  内山和彦，八木信明，内藤裕二．
- Journal Title
  
  G.I. Research
  
  Volume: 24 Pages: 36-41
- Data Source
  KAKENHI-PROJECT-16H05289
[Journal Article] Carbon monoxide promotes gastric wound healing in mice via the protein kinase C pathway.2016
- Author(s)
  Takagi T, Naito Y, Uchiyama K, Mizuhima K, Suzuki T, Horie R, Hirata I, Tsuboi H, Yoshikawa T.
- Journal Title
  
  Free Radic Res.
  
  Volume: 50(10) Pages: 1098-1105
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-16K09322
[Journal Article] Prevention of colitis by controlled oral drug delivery of carbon monoxide.2016
- Author(s)
  Steiger C, Uchiyama K, Takagi T, Mizushima K, Higashimura Y, Gutmann M, Hermann C, Botov S, Schmalz HG, Naito Y, Meinel L.
- Journal Title
  
  J Control Release.
  
  Volume: 239 Pages: 128-36
- DOI
  10.1016/j.jconrel.2016.08.030
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K09322, KAKENHI-PROJECT-16K16281
[Journal Article] Butyrate and bioactive proteolytic form of Wnt-5a regulate colonic epithelial proliferation and spatial development2016
- Author(s)
  Kazuhiko Uchiyama, Toshio Sakiyama, Takumu Hasebe, Mark W. Musch, Hiroyuki Miyoshi, Yasushi Nakagawa, Tong-Chuan He, Lev Lichtenstei,, Yuji Naito, Yoshito Itoh, Toshikazu Yoshikawa, Bana Jabri, Thaddeus Stappenbeck, Eugene B. Chang
- Journal Title
  
  Scientific Reports
  
  Volume: 6 Issue: 1 Pages: 32094-32094
- DOI
  10.1038/srep32094
- Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K08313
[Journal Article] Multiple targets of carbon monoxide gas in the intestinal inflammation.2016
- Author(s)
  Naito Y, Takagi T, Uchiyama K, Katada K, Yoshikawa T.
- Journal Title
  
  Arch Biochem Biophys.
  
  Volume: 595 Pages: 147-52
- DOI
  10.1016/j.abb.2015.06.020
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-25460959, KAKENHI-PROJECT-16K09322
[Journal Article] Rapamycin Improves Mortality Following Intestinal Ischemia-Reperfusion via the Inhibition of Remote Lung Inflammation in Mice. Digestion. 2015;92:211-9.2015
- Author(s)
  Iida T, Takagi T, Katada K, Mizushima K, Fukuda W, Kamada K, Uchiyama K, Handa O, Ichikawa H, Naito Y, Itoh Y.
- Journal Title
  
  Digestion
  
  Volume: 92 Issue: 4 Pages: 211-219
- DOI
  10.1159/000439300
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-25460958
[Journal Article] Peptidomic analysis via one-step direct transfer technology for colorectal cancer biomarker discovery2015
- Author(s)
  Uchiyama K, Naito Y, Yagi N, Mizushima K, Higashimura Y, Hirai Y, Okayama T, Yoshida N, Katada K, Kamada K, Handa O, Ishikawa T, Takagi T, Konishi H, Nonaka D, Asada K, Tanaka K, Nakanishi M, Otsuji E, Itoh Y.
- Journal Title
  
  J Proteomics Bioinform
  
  Volume: S5 Pages: 1-8
- DOI
  10.4172/jpb.s5-005
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-25460958
[Journal Article] The therapeutic potential of carbon monoxide for inflammatory bowel disease2015
- Author(s)
  Takagi T, Uchiyama K, Naito Y.
- Journal Title
  
  Digestion
  
  Volume: 91(1) Issue: 1 Pages: 13-18
- DOI
  10.1159/000368765
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-25460959, KAKENHI-PROJECT-25460958
[Journal Article] Propionate Promotes Fatty Acid Oxidation through the Up-Regulation of Peroxisome Proliferator-Activated Receptor α in Intestinal Epithelial Cells2015
- Author(s)
  Higashimura, Y., Naito Y., Takagi T., Uchiyama K., Mizushima K., and Yoshikawa T.
- Journal Title
  
  Journal of Nutritional Science and Vitaminology
  
  Volume: 61 Issue: 6 Pages: 511-515
- DOI
  10.3177/jnsv.61.511
- NAID
  130005125490
- ISSN
  0301-4800, 1881-7742
- Language
  English
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-25750050, KAKENHI-PROJECT-25460958
[Journal Article] New genetic biomarkers predicting azathioprine blood concentrations in combination therapy with 5-aminosalicylic Acid.2014
- Author(s)
  Uchiyama K, Takagi T, Iwamoto Y, Kondo N, Okayama T, Yoshida N, Kamada K, Katada K, Handa O, Ishikawa T, Yasuda H, Sakagami J, Konishi H, Yagi N, Naito Y, Itoh Y
- Journal Title
  
  PLoS One
  
  Volume: 24;9(4) Issue: 4 Pages: e95080-e95080
- DOI
  10.1371/journal.pone.0095080
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-24590665, KAKENHI-PROJECT-25460958
[Journal Article] New genetic biomarkers predicting azathioprine blood concentrations in combination therapy with 5-aminosalicylic acid.2014
- Author(s)
  Uchiyama K, Takagi T, Iwamoto Y, Kondo N, Okayama T, Yoshida N, Kamada K, Katada K, Handa O, Ishikawa T, Yasuda H, Sakagami J, Konishi H, Yagi N, Naito Y, Itoh Y.
- Journal Title
  
  PLoS One
  
  Volume: 9
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-24590665
[Journal Article] Serpin B1 protects colonic epithelial cell via blockage of neutrophil elastase activity and its expression is enhanced in patients with ulcerative colitis2012
- Author(s)
  Kazuhiko Uchiyama
- Journal Title
  
  Am J Physiol Gastrointest Liver Physiol
  
  Volume: 15 Issue: 10 Pages: G1163-G1170
- DOI
  10.1152/ajpgi.00292.2011
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21790688
[Journal Article] Serpin B1 protects colonic epithelial cell via blockage of neutrophil elastase activity and its expression is enhanced in patients with ulcerative colitis2012
- Author(s)
  Uchiyama K, Naito Y, Takagi T, et al.
- Journal Title
  
  Am J Physiol Gastrointest Liver Physiol
  
  Volume: 302(10)
- Data Source
  KAKENHI-PROJECT-21790688
[Journal Article] FGF19 protects colonic epithelial cells against hydrogen peroxide2011
- Author(s)
  Uchiyama K, Naito Y, Takagi T, et al.
- Journal Title
  
  Digestion
  
  Volume: 83(3) Pages: 180-3
- Data Source
  KAKENHI-PROJECT-21790688
[Journal Article] FGF19 protects colonic epithelial cells against hydrogen peroxide2011
- Author(s)
  Uchiyama K, Naito Y, Takagi T, Mizushima K, Hayashi N, Handa O, Ishikawa T, Yagi N, Kokura S, Yoshikawa T
- Journal Title
  
  Digestion
  
  Volume: 83 Issue: 3 Pages: 180-3
- DOI
  10.1159/000321809
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21390184, KAKENHI-PROJECT-21790688, KAKENHI-PROJECT-22590705
[Journal Article] Carbon monoxide (CO) enhance colonic epithelial restitution via FGF15 derived from colonic myofibroblast2010
- Author(s)
  Kazuhiko Uchiyama
- Journal Title
  
  Biochemical and Biophysical Research Communications 391(1)
  
  Pages: 1122-1126
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21790688
[Journal Article] Carbon monoxide enhance colonic epithelial restitution via FGF15 derived from colonic myofibroblasts2010
- Author(s)
  Uchiyama K, Naito Y, Takagi T, et al.
- Journal Title
  
  Biochem Biophys Res Commun
  
  Volume: 391(1) Pages: 1122-6
- Data Source
  KAKENHI-PROJECT-21790688
[Presentation] 新規治療分子としてのCOの可能性～微小循環研究の知見から～．2022
- Author(s)
  185髙木智久、内山和彦、堅田和弘、内藤裕二．
- Organizer
  第47回日本微小循環学会総会. シンポジウム1「歯科、消化器、微小循環研究の新展開」
- Data Source
  KAKENHI-PROJECT-20K08292
[Presentation] 環状ジヌクレオチドは樹状細胞を介してTh17産生を誘導する2021
- Author(s)
  尾松達司、水島かつら、内山和彦、高木智久、八木信明、内藤裕二
- Organizer
  第58回日本消化器免疫学会総会
- Data Source
  KAKENHI-PROJECT-18K07955
[Presentation] 腸管炎症病態における抗酸化酵素Heme oxygenase-1の役割とその生成物Carbon monoxideの新規治療分子としての可能性2020
- Author(s)
  髙木智久、内山和彦、鎌田和浩、内藤裕二
- Organizer
  第20回日本抗加齢医学会総会
- Data Source
  KAKENHI-PROJECT-20K08292
[Presentation] 大腸癌診断における血清ペプチドバイオマーカーの有用性に関する検討2019
- Author(s)
  内山和彦、八木信明、内藤裕二
- Organizer
  第105回に本消化器病学会総会
- Data Source
  KAKENHI-PROJECT-16H05289
[Presentation] Proteolytic bioactive form of Wnt5a is related to the pathogenesis of IBD in view of mucosal healing and anti-inflammation2018
- Author(s)
  Uchiyama Kazuhiko, Tomohisa Takagi, Yuji Naito
- Organizer
  JDDW 2018
- Data Source
  KAKENHI-PROJECT-18K06224
[Presentation] Heme oxygenase-1 regulates the intestinal inflammation in murine colitis model2018
- Author(s)
  Tomohisa Takagi, Yuji Naito, Katsura Mizushima, Yasuko Hirai, Kazuhiko Uchiyama, and Yoshito Itoh
- Organizer
  10th International Symposium on Cell/ Tissue Injury and Cytoprotection/Organoprotection (ISCTICO)
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K09322
[Presentation] 腸管炎症病態における Heme oxygenase-1/Carbon monoxide系の新規治療標的分子としての可能性2018
- Author(s)
  髙木智久、内山和彦、豊川優季、東村泰希、柏木里織、後田ちひろ、水島かつら、平井泰子、鎌田和浩、石川剛、半田修、内藤裕二
- Organizer
  第71回日本酸化ストレス学会学術集会
- Data Source
  KAKENHI-PROJECT-16K09322
[Presentation] Carbon monoxide promotes intestinal mucosal healing in colitis model2016
- Author(s)
  Tomohisa Takagi, Yuji Naito, Kazuhiro Uchiyama, Yasuki Higashimura, Katsura Mizushima, Yohito Itoh
- Organizer
  9TH International conference on Heme Oxygenase
- Place of Presentation
  Prague
- Year and Date
  2016-09-14
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K09322
[Presentation] マウス実験腸炎モデルにおけるSPARCの役割2015
- Author(s)
  田中　信、髙木智久、内藤裕二、内山和彦、堀田祐馬、水島かつら、東村泰希、吉田直久、鎌田和浩、堅田和弘、石川　剛、半田　修、小西英幸、伊藤義人.
- Organizer
  第101回日本消化器病学会総会
- Place of Presentation
  仙台
- Year and Date
  2015-04-24
- Data Source
  KAKENHI-PROJECT-25460958
[Presentation] 炎症病態とSPARCの関与についての検討2015
- Author(s)
  田中　信、髙木智久、内山和彦、堀田祐馬、水島かつら、東村泰希、岡山哲也、鎌田和浩、堅田和弘、石川　剛、半田　修、内藤裕二、伊藤義人.
- Organizer
  第57回日本消化器病学会大会
- Place of Presentation
  東京
- Year and Date
  2015-10-09
- Data Source
  KAKENHI-PROJECT-25460958
[Presentation] 大腸炎症病態におけるSecreted Protein Acidic and Rich in Cystein (SPARC)の役割2015
- Author(s)
  田中　信，髙木智久，内山和彦，豊川優希，堀田祐馬，水島かつら，東村泰希，岡山哲也，堅田和弘，半田　修，石川　剛，内藤裕二，伊藤義人．
- Organizer
  第52回日本消化器免疫学会総会
- Place of Presentation
  東京
- Year and Date
  2015-07-31
- Data Source
  KAKENHI-PROJECT-25460958
[Presentation] Allele解析をもとにしたSLC38A9の遺伝子多型と炎症性腸疾患の治療におけるazathioprineの薬物代謝に関する検討2013
- Author(s)
  内山和彦
- Organizer
  第99回日本消化器病学会総会
- Place of Presentation
  鹿児島
- Data Source
  KAKENHI-PROJECT-24590665
[Presentation] Allele解析によって明らかとなったSLC38A9の遺伝子多型と炎症性腸疾患の治療におけるazathioprineの薬物代謝に関する検討2013
- Author(s)
  内山和彦
- Organizer
  第50回日本臨床分子医学会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-24590665
[Presentation] Azathioprine血中濃度予測バイオマーカーとしてのSLC38A9遺伝子多型の有用性に関する解析2013
- Author(s)
  内山和彦、高木智久、堅田和弘、鎌田和浩、半田　修、保田宏明、阪上順一、小西英幸、八木信明、内藤裕二、伊藤義人
- Organizer
  第50回日本消化器免疫学会総会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-24590665
[Presentation] Enhancement of colonic mucosal repair and protection by FGF15/19 derived from myofibroblasts2013
- Author(s)
  Kazuhiko Uchiyama, Yuji Naito, Tomohisa Takagi, Wataru Fukuda, Kazuhiro Katada, Kazuhiro Kamada, Osamu Handa, Nobuaki Yagi, Toshikazu Yoshikawa
- Organizer
  16th International Congress of Mucosal Immunology (ICMI 2013)
- Place of Presentation
  Vancouver, Canada
- Data Source
  KAKENHI-PROJECT-24590665
[Presentation] Investigation of new biomarker for diagnosis of colorectal cancer ; the usability of F marker;2012
- Author(s)
  内山和彦
- Organizer
  第20回欧州消化器病週間（UEGW 2012）
- Place of Presentation
  Amsterdam
- Data Source
  KAKENHI-PROJECT-24590665
[Presentation] 大腸上皮細胞のSERPINB1(monocyte neutrophil elastase inhibitor)発現と潰瘍性大腸炎の病態への関与2011
- Author(s)
  内山和彦
- Organizer
  第32回日本炎症再生学会
- Place of Presentation
  京都
- Year and Date
  2011-06-03
- Data Source
  KAKENHI-PROJECT-21790688
[Presentation] Myofibroblast-Derived Wnt5a Regulates Epithelial Cell Heat Shock Protein 25 Expression and Proliferation2010
- Author(s)
  Uchiyama K, Naito Y, et al.
- Organizer
  The 1st JSGE International Topic Conference
- Place of Presentation
  鎌倉パークホテル、神奈川
- Data Source
  KAKENHI-PROJECT-21790688
[Presentation] Myofibroblast-derived FGF15/19 protects colonic mucosa and enhances mucosal repair in IBD.2010
- Author(s)
  Kazuhiko Uchiyama
- Organizer
  DDW 2010, New Orleans
- Place of Presentation
  New Orleans, USA
- Year and Date
  2010-05-01
- Data Source
  KAKENHI-PROJECT-21790688
[Presentation] Myofibroblast-derived FGF15/19 protects colonic mucosa and enhances mucosal repair in IBD2010
- Author(s)
  Uchiyama K, Naito Y, et al.
- Organizer
  DDW
- Place of Presentation
  New Orleans, USA
- Year and Date
  2010-05-01
- Data Source
  KAKENHI-PROJECT-21790688
[Presentation] 大腸上皮細胞の増殖におけるmyofibroblast由来Wnt5aのHeat Shock Protein(Hsp) 25抑制効果とその意義2009
- Author(s)
  内山和彦、内藤裕二他
- Organizer
  第46回日本消化器免疫学会総会
- Place of Presentation
  松山全日空ホテル、愛媛
- Data Source
  KAKENHI-PROJECT-21790688
[Presentation] 大腸上皮細胞のHeat Shock Protein(Hsp) 25発現抑制の意義に関する検討.大腸Myofibroblast由来Wnt-5aの役割2009
- Author(s)
  内山和彦、内藤裕二他
- Organizer
  第5回日本消化管学会総会
- Place of Presentation
  京王プラザホテル、東京
- Data Source
  KAKENHI-PROJECT-21790688
[Presentation] Identification of New Genetic Biomarkers Predicting the Azathioprine Blood Concentration with 5-aminosalicylic acid as Combination Therapy for Inflammatory Bowel Disease
- Author(s)
  Kazuhiko Uchiyama, Yuji Naito, Tomohisa Takagi, Yasunori Iwamoto, Yasuhisa Nemoto, Kazuhiro Katada, Kazuhiro Kamada, Osamu Handa, Hiroaki Yasuda, Junichi Sakagami, Hideyuki Konishi, Nobuaki Yagi, Toshikazu Yoshikawa
- Organizer
  The 1st Annual Meeting of AOCC
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-24590665
[Presentation] Allele解析によって明らかとなったSLC38A9の遺伝子多型と炎症性腸疾患の治療におけるazathioprineの薬物代謝に関する検討
- Author(s)
  内山和彦、内藤裕二、高木智久、堅田和弘、鎌田和浩、半田　修、保田宏明、阪上順一、小西英幸、八木信明、伊藤義人
- Organizer
  第50回日本臨床分子医学会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-24590665
[Presentation] HO-1高発現M2マクロファージを標的にしたIBD治療
- Author(s)
  内藤裕二，髙木智久，内山和彦，堅田和弘，東村泰希
- Organizer
  第50回日本消化器免疫学会総会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-25460958

1. TAKAGI Tomohisa (70405257)

# of Collaborated Projects: 11 results

# of Collaborated Products: 40 results
2. NAITO Yuji (00305575)

# of Collaborated Projects: 11 results

# of Collaborated Products: 45 results
3. Omatsu Tatsushi (50367562)

# of Collaborated Projects: 2 results

# of Collaborated Products: 1 results
4. 堅田和弘 (60593910)

# of Collaborated Projects: 2 results

# of Collaborated Products: 6 results
5. ITO Tomoko (80329648)

# of Collaborated Projects: 1 results

# of Collaborated Products: 5 results
6. 吉田直久 (50340089)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
7. 東村泰希 (70628924)

# of Collaborated Projects: 1 results

# of Collaborated Products: 5 results
8. 半田修 (90381970)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
9. 川人豊 (50336731)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. 妹尾高宏 (10625833)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. YOSHIKAWA Toshikazu

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
12. 後田ちひろ

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
13. 小西英幸

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Uchiyama Kazuhiko 内山 和彦

UCHIYAMA Kazuhiko 内山 和彦

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Investigation of the pathogenesis about relapse in ulcerative colitis based on colonic mucosal gene expressionPrincipal Investigator

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The effect of Wnt5a derived peptide to reduce intestinal inflammationPrincipal Investigator

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The role of Wnt5a peptide to enhance colonic epithelial healing for the treatment of IBDPrincipal Investigator

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The examination about the usefulness of SLC38A9 as genetic biomarker to predict blood concentration of azathioprine.Principal Investigator

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The role of Wnt-5a as the pathological marker of inflammatory bowel disease.Principal Investigator

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[Journal Article] Role and Potential Mechanism of Heme Oxygenase-1 in Intestinal Ischemia-Reperfusion Injury.2022

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Uchiyama Kazuhiko 内山和彦

UCHIYAMA Kazuhiko 内山和彦