KUBOTA Takehiko 久保田健彦

Researcher Number	50303136
Other IDs	https://orcid.org/0000-0002-0730-861X
Affiliation (based on the past Project Information) *help	2005 – 2019: 新潟大学, 医歯学総合病院, 講師 2001 – 2004: 新潟大学, 大学院・医歯学総合研究科, 助手 2000: 新潟大学, 歯学部, 助手
Review Section/Research Field	Principal Investigator Periodontal dentistry / Periodontology Except Principal Investigator Periodontal dentistry / Periodontal dentistry / Surgical dentistry / Periodontology
Keywords	Principal Investigator 病理学 / 免疫学 / 歯学 / 医療・福祉 / アルツハイマー病 / 歯周病 / タンパク質局在 / 遺伝子発現 / 免疫病理 / 遺伝子 … More / ネットワーク解析 / 免疫病理学 / 遺伝子解析 / 酵素 / 歯周免疫機能学 / matrix metalloproteinases / diagnosis / susceptibility / periodontitis / gene polymorphisms / matrix metalloproteinase … More Except Principal Investigator 歯周炎 / 好中球 / Oral squamous ell carcinoma / Outcome / Distant metastasis / Cervical lymph node metastasis / Biomarker / Tetraspanin / Integrin / MMP-1 / 易罹病性 / SNP / 口腔扁平上皮癌 / 歯周治療 / 抗菌的光線力学療法 / ミノサイクリン / スケーリング / 炎症性サイトカイン / 生体応答 / ゲノム / インターロイキン6 / ｴﾋﾟｼﾞｪﾈﾃｨｸｽ / エピジェネティクス / IL-6 / リウマチ / 蛋白質 / 遺伝子 / 歯学 / プロテオーム / RNA発現 / リスク遺伝子 / 膠原病 / 歯肉溝滲出液 / 歯肉血流 / 遺伝子発現 / 禁煙 / gene expression / neutrophil / GCF / blood flow / smoking cessation / RAP-PCR / 早期発症型歯周炎 Less

Gene network analyses of AD in periodontitis-affected gingival tissuePrincipal Investigator
- Principal Investigator
  
  KUBOTA Takehiko
- Project Period (FY)
  2015 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Periodontology
- Research Institution
  Niigata University
Biological responses due to bacteremia following scaling and application effects of optical energy
- Principal Investigator
  
  MOROZUMI TOSHIYA
- Project Period (FY)
  2014 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Periodontology
- Research Institution
  Niigata University
Elevated expression of Alzheimer disease related genes in periodontiti-affected gingival tissuesPrincipal Investigator
- Principal Investigator
  
  Kubota Takehiko
- Project Period (FY)
  2012 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Periodontal dentistry
- Research Institution
  Niigata University
The role of interleukin-6 epigenetics in the pathogenesis of periodontitis and rheumatoid arthritis
- Principal Investigator
  
  YOSHIE Hiromasa
- Project Period (FY)
  2010 – 2012
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Periodontal dentistry
- Research Institution
  Niigata University
Pathological roles of tissue inhibitors of metalloproteinases in the tissues of drug-induced fibrous gingival over growth.Principal Investigator
- Principal Investigator
  
  KUBOTA Takehiko
- Project Period (FY)
  2009 – 2011
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Periodontal dentistry
- Research Institution
  Niigata University
RNA and protein expression based on risk gene polymorphisms in periodontitis and collagen diseases
- Principal Investigator
  
  YOSHIE Hiromasa
- Project Period (FY)
  2007 – 2009
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Periodontal dentistry
- Research Institution
  Niigata University
2G allile of MMP-1 gene polymorphism increases risk of oral cancer
- Principal Investigator
  
  HOSHINA Hideyuki
- Project Period (FY)
  2006 – 2007
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Surgical dentistry
- Research Institution
  Niigata University
MMPの転写促進活性を有する遺伝子多型は歯周病のリスクファクターになりうるか?Principal Investigator
- Principal Investigator
  
  久保田健彦
- Project Period (FY)
  2003 – 2005
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Periodontal dentistry
- Research Institution
  Niigata University
禁煙によるヒト好中球遺伝子発現の変化
- Principal Investigator
  
  吉江弘正
- Project Period (FY)
  2002 – 2004
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  Periodontal dentistry
- Research Institution
  Niigata University
早期発症型歯周炎患者に特異的な好中球遺伝子発現
- Principal Investigator
  
  YOSHIE Hiromasa
- Project Period (FY)
  2000 – 2001
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  Periodontal dentistry
- Research Institution
  Niigata University

[Book] 歯周組織再生と歯根膜.歯界展望別冊「歯と歯列を守るための歯根膜活用術」2011
- Author(s)
  久保田健彦、吉江弘正
- Total Pages
  146
- Publisher
  医歯薬出版
- Data Source
  KAKENHI-PROJECT-21592622
[Book] 歯周組織再生と歯根膜.歯界展望別冊「歯と歯列を守るための歯根膜活用術」2011
- Author(s)
  久保田健彦、吉江弘正
- Publisher
  医歯薬
- Data Source
  KAKENHI-PROJECT-21592622
[Journal Article] 歯周炎歯肉組織局所の細胞外マトリックス代謝調節遺伝子発現解析と全身疾患の関連解明2018
- Author(s)
  久保田健彦
- Journal Title
  
  日本歯周病学会雑誌
  
  Volume: 60 Pages: 123-130
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15K11382
[Journal Article] Clinical and cone-beam CT evaluation of combinational periodontal regenerative therapies using enamel matrix derivative and deproteinized bovine bone mineral with or without collagen membrane2018
- Author(s)
  Nemoto Y, Kubota T, Nohno K, Nezu A, Morozumi T, Yoshie H
- Journal Title
  
  International Journal of Periodontics & Restorative Dentistry
  
  Volume: 印刷中 Issue: 3 Pages: 373-381
- DOI
  10.11607/prd.3288
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-26463132, KAKENHI-PROJECT-17K11984
[Journal Article] Expression of neprilysin in periodontitis-affected gingival tissues.2017
- Author(s)
  Nezu A, Kubota T, Maruyama S, Nagata M, Nohno K, Morizumi T, Yoshie H.
- Journal Title
  
  Arch Oral Biol.
  
  Volume: 79 Pages: 35-41
- DOI
  10.1016/j.archoralbio.2017.03.003
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K11069, KAKENHI-PROJECT-15K11382, KAKENHI-PROJECT-17K11984, KAKENHI-PROJECT-26463132
[Journal Article] Expression od neprilysin in periodontitis-affected gingival tissues2017
- Author(s)
  Nezu A, Kubota T, Maruyama S, Nagata M, Horimizu M, Nohno K, Hokari T, Morozumi T, Yoshie H
- Journal Title
  
  J Int Academy Periodontol
  
  Volume: 19
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K11382
[Journal Article] Changes in biomarkers after initial periodontal treatment in gingival crevicular fluid from patients with chronic periodontitis presenting with drug-induced gingival overgrowth2016
- Author(s)
  Shimizu T, Kubota T, Iwasaki M, Morozumi T, Yoshie H
- Journal Title
  
  Open Journal of Stomatology
  
  Volume: 6 Issue: 02 Pages: 64-72
- DOI
  10.4236/ojst.2016.62008
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-26463132, KAKENHI-PROJECT-26861809
[Journal Article] Microbiological Effects of a Low-concentration Chlorhexidine Hydrochloride/cetylpyridinium Chloride Mouth Rinse for Patients with Periodontitis2014
- Author(s)
  杉田典子、中曽根直弘、花井悠貴、高橋昌之、伊藤晴江、両角俊哉、久保田健彦、奥田一博、吉江弘正
- Journal Title
  
  The Japanese Journal of Conservative Dentistry
  
  Volume: 57 Issue: 3 Pages: 219-228
- DOI
  10.11471/shikahozon.57.219
- NAID
  130004669783
- ISSN
  0387-2343, 2188-0808
- Language
  Japanese
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-26463132
[Journal Article] Amyloid beta (A4) precursor protein expression in human periodontitis-affected gingival tissues.2014
- Author(s)
  Kubota T, Maruyama S, Abe D, Tomita T, Morozumi T, Nakasone N, Saku T, Yoshie H.
- Journal Title
  
  Arch Oral Biol.
  
  Volume: 59(6) Issue: 6 Pages: 586-94
- DOI
  10.1016/j.archoralbio.2014.03.004
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-24592829, KAKENHI-PROJECT-24593119, KAKENHI-PROJECT-26463132
[Journal Article] Microarray and quantitative RT-PCR analyses in calcium-channel blockers induced gingival overgrowth tissues of periodontitis patients2011
- Author(s)
  Shimizu T, Kubota T, Nakasone N, Abe D, Morozumi T, Yoshie H
- Journal Title
  
  Arch Oral Biol
  
  Volume: 56 Pages: 277-284
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21592622
[Journal Article] Altered gene expression in leukocyte transendothelial migration and cell communication pathways in periodontitis-affected gingival tissues2011
- Author(s)
  Abe D, Kubota T, Morozumi T, Shimizu T, Nakasone N, Itagaki M, Yoshie H
- Journal Title
  
  J Periodontal Res
  
  Volume: 46 Issue: 3 Pages: 345-353
- DOI
  10.1111/j.1600-0765.2011.01349.x
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21592622, KAKENHI-PROJECT-22390396, KAKENHI-PROJECT-23792473
[Journal Article] Micro array and quantitative RT-PCR analyses in calcium-channel blockers induced gingival overgrowth tissues of periodontitis patients2011
- Author(s)
  Shimizu T, Kubota T, Nakasone N, Abe D, Morozumi T, Yoshie H
- Journal Title
  
  Arch Oral Biol
  
  Volume: 56 Issue: 3 Pages: 277-284
- DOI
  10.1016/j.archoralbio.2010.10.002
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21592622, KAKENHI-PROJECT-23792473
[Journal Article] Altered gene expression in leukocyte transendothelial migration and cell communication pathways in periodontitis-affected gingival tissues2011
- Author(s)
  Abe D, Kubota T.Morozumi T, ShimizuT, Nakasone N, Itagaki M, Yoshie H.
- Journal Title
  
  JPeriodontal Res
  
  Volume: in press
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21592622
[Journal Article] Altered gene expression in leukocyte transendothelial migration and cell communication pathways in periodontitis-affected gingival tissues2011
- Author(s)
  Abe D, Kubota T, Morozumi T, Shimizu T, Nakasone N, Itagaki M, Yoshie H.
- Journal Title
  
  J Periodont Res
  
  Volume: 46 Pages: 345-353
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21592622
[Journal Article] 歯周炎組織破壊における生体酵素動態と歯周炎感受性診断2010
- Author(s)
  久保田健彦、ミニレビュー
- Journal Title
  
  日本歯科保存学会雑誌
  
  Volume: 53巻 Pages: 6-8
- NAID
  110007880704
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21592622
[Journal Article] ミニレビュー:歯周炎組織破壊における生体酵素動態と歯周炎感受性診断2010
- Author(s)
  久保田健彦
- Journal Title
  
  日本歯科保存学会雑誌 53
  
  Pages: 6-8
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21592622
[Journal Article] ミニレビュー:歯周炎組織破壊における生体酵素動態と歯周炎感受性診断2010
- Author(s)
  久保田健彦
- Journal Title
  
  日本歯科保存学会雑誌
  
  Volume: 53 Pages: 6-8
- Data Source
  KAKENHI-PROJECT-21592622
[Journal Article] Differential gene and protein expression of tissue inhibitors of metalloproteinases (TIMP)-3 and TIMP-4 in gingival tissues from drug induced gingival overgrowth.2009
- Author(s)
  Nakasone N, Kubota T, Hoshino C, Nohno K, Itagaki M, Shimizu T, Yoshie H
- Journal Title
  
  Arch Oral Biol 54
  
  Pages: 634-641
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21592622
[Journal Article] Differential gene and protein expression of tissue inhibitors of metalloproteinases(TIMP)-3 and TIMP-4 in gingival tissues from drug induced gingival overgrowth2009
- Author(s)
  Nakasone N, Kubota T, Hoshino C, Nohno K, Itagaki M, Shimizu T, Yoshie H
- Journal Title
  
  Arch Oral Biol
  
  Volume: 54 Pages: 634-641
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21592622
[Journal Article] Altered gene expression levels of matrix metalloprotein ases and their hihibitors in periodontitis-affected gingival tissue2008
- Author(s)
  久保田健彦
- Journal Title
  
  Journal of Periodontology 79
  
  Pages: 166-173
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19390535
[Journal Article] Altered gene expression levels of matrix metalloproteinases and their inhibitors in periodontitis-affected gingival tissue2008
- Author(s)
  Kubota T, Itagaki M, Oshino C, Nagata M, Morozumi T, Kobayashi T, Takagi R, Yoshie H
- Journal Title
  
  J. Periodontol 79(1)
  
  Pages: 166-173
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19390535
[Journal Article] The 2G allele of promoter region of Matrix metalloproteinase-1 as an essential pre-condition for the early onset of oral squamous cell carcinoma2007
- Author(s)
  Nishizawa, R., Nagata, M., Kitamura, N., Fujita, H., Hoshina, H., Noman, Arhab, Kubota, T., Itagaki, M., Shingaki, S., Ohnishi, M., Kurita, H., Katsura, K., Saito, C., Yoshie, H., Takagi, R
- Journal Title
  
  BMC Cancer 7
  
  Pages: 187-187
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18592171
[Journal Article] Matrix metalloproteinase-1 and -3 gene promoter polymorphisms in Japanese patients with periodontitis2004
- Author(s)
  Itagaki M, Kubota T et al.
- Journal Title
  
  Journal of Clinical Periodontology 31
  
  Pages: 764-789
- Data Source
  KAKENHI-PROJECT-15791235
[Patent] MMP-1遺伝子のSNPを用いた口腔癌の検査方法2005
- Inventor(s)
  永田昌毅, 久保田健彦
- Industrial Property Rights Holder
  新潟大学
- Industrial Property Number
  2005-194121
- Filing Date
  2005-07-01
- Data Source
  KAKENHI-PROJECT-15791235
[Presentation] 歯周炎歯肉組織局所の細胞外マトリックス代謝調節遺伝子発現解析と全身疾患の関連解明2018
- Author(s)
  久保田健彦
- Organizer
  日本歯周病学会春季学術大会(第61回）
- Invited
- Data Source
  KAKENHI-PROJECT-15K11382
[Presentation] 専門医が明かす歯周病2017
- Author(s)
  久保田健彦
- Organizer
  2017年中国ハルビン歯科新発展研究会
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K11382
[Presentation] Clinical and three-dimensiona evaluation of combinational periodontal regenerative therapy using enamel matrix derivative, deproteinized bovine bone mineral with or without collagen membrane2017
- Author(s)
  Kubota T, Nemoto Y, Nohno K, Nezu A, Horimizu M, Morozumi T, Yoshie H
- Organizer
  National Symposium OSTEOLOGY JAPAN
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26463132
[Presentation] 専門医が明かす歯周病2017
- Author(s)
  久保田健彦
- Organizer
  まちなかキャンパス長岡・講座医療見聞録II
- Invited
- Data Source
  KAKENHI-PROJECT-15K11382
[Presentation] Effectiveness of periodontal regenerative therapy using enamel matrix derivative, deproteinised bovine bone mineral with or without collagen membrane2017
- Author(s)
  Kubota T, Nemoto Y, Nohno K, Morozumi T, Horimizu M, Yoshie H
- Organizer
  16th International Congress of Periodontology of the International Academy of Periodontology
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26463132
[Presentation] 慢性歯周炎に対する抗菌的光線力学療法と局所薬物配送システムの臨床および微生物学的効果2017
- Author(s)
  保苅崇大,両角俊哉,小松康高,久保田健彦,吉江弘正
- Organizer
  日本歯科保存学会2017年度春季学術大会
- Data Source
  KAKENHI-PROJECT-26463132
[Presentation] Expression of neprilysin in periodontitis-affected gingival tissues2017
- Author(s)
  Nezu A, Kubota T, Maruyama S, Nagata M, Horimizu M, Nohno K, Hokari T, Morozumi T, Yoshie H
- Organizer
  6th International Congress of Periodontology of the International Academy of Periodontology
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K11382
[Presentation] 広汎型重度慢性歯周炎患者において歯周基本治療と根分岐部病変治療（トンネリング）により改善を認めた一症例2017
- Author(s)
  両角俊哉,保苅崇大,小松康高,久保田健彦,奥田一博,吉江弘正
- Organizer
  第60回春季日本歯周病学会学術大会
- Data Source
  KAKENHI-PROJECT-26463132
[Presentation] 歯と健康 ―専門医が明かす歯周病―2017
- Author(s)
  久保田健彦
- Organizer
  2017年度新潟妙高会講演会
- Invited
- Data Source
  KAKENHI-PROJECT-15K11382
[Presentation] Expression of neprilysin in periodontitis-affected gingival tissues2017
- Author(s)
  Nezu A, Kubota T, Maruyama S, Nagata M, Horimizu M, Nohno K, Hokari T, Morozumi T, Yoshie H
- Organizer
  16th International Congress of Periodontology of the International Academy of Periodontology
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26463132
[Presentation] 慢性歯周炎に対する抗菌的光線力学療法と局所薬物配送システムの臨床および生物学的効果2017
- Author(s)
  保苅崇大,両角俊哉,小松康高,清水太郎,吉野敏明,田中真喜,田中良枝,久保田健彦,吉江弘正
- Organizer
  平成29年度新潟歯学会第1回例会
- Data Source
  KAKENHI-PROJECT-26463132
[Presentation] エナメル基質タンパク，脱タンパクウシ骨基質を用いた歯周組織再生療法におけるコラーゲン膜の有効性の検討2016
- Author(s)
  根本康子，久保田健彦，両角俊哉，濃野要，根津新，吉江弘正
- Organizer
  第59回春季日本歯周病学会学術大会
- Place of Presentation
  かごしま県民交流センター（鹿児島県鹿児島市）
- Year and Date
  2016-05-20
- Data Source
  KAKENHI-PROJECT-26463132
[Presentation] 慢性歯周炎に対する抗菌的光線力学療法と局所薬物配送システムの生物学的効果2016
- Author(s)
  保苅崇大，両角俊哉，小松康高，清水太郎，吉野敏明，田中真喜，田中良枝，久保田健彦，吉江弘正
- Organizer
  第59回春季日本歯周病学会学術大会
- Place of Presentation
  かごしま県民交流センター（鹿児島県鹿児島市）
- Year and Date
  2016-05-20
- Data Source
  KAKENHI-PROJECT-26463132
[Presentation] Expression of neprilysin in periodontitis-affected gingival tissues2016
- Author(s)
  Nezu A, Kubota T, Maruyama S, Nagata M, Horimizu M, Nouno K, Hokari T, Morozumi T, Saku T, Yoshie H
- Organizer
  The 102nd Annual Meeting of the American Academy of Periodontology in collaboration with the Japanese Society of Periodontology and Japanese Academy of Clinical Periodontology
- Place of Presentation
  San Diego Convention Center (San Diego, CA, U.S.A.)
- Year and Date
  2016-09-10
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26463132
[Presentation] Expression of neprilysin in periodontitis-affected gingival tissues2016
- Author(s)
  A Nezu, T Kubota, S Maruyama, M Nagata, M Horimizu, K Nouno, T Hokari, T Morozumi, T Saku, H　Yoshie
- Organizer
  The 102nd Annual Meeting of the American Academy of Periodontology in collaboration with the Japanese Society of Periodontology and Japanese Academy of Clinical Periodontology
- Place of Presentation
  SanDiego, CA, USA
- Year and Date
  2016-09-10
- Data Source
  KAKENHI-PROJECT-15K11382
[Presentation] エナメル基質タンパク, 脱タンパクウシ骨基質を用いた歯周組織再生療法におけるコラーゲン膜の有効性の検討2016
- Author(s)
  根本康子，久保田健彦，濃野要，根津新，両角俊哉，吉江弘正
- Organizer
  平成28年度新潟歯学会第2回例会
- Place of Presentation
  新潟大学歯学部（新潟県新潟市）
- Data Source
  KAKENHI-PROJECT-26463132
[Presentation] 歯周炎罹患歯肉組織におけるネプリライシンの遺伝子発現レベルと免疫組織局在の解析2016
- Author(s)
  根津新, 久保田健彦, 丸山智, 永田昌毅, 堀水慎, 濃野要, 保苅崇大, 両角俊哉, 朔敬, 吉江弘正
- Organizer
  平成28年度新潟歯学会第2回例会
- Place of Presentation
  新潟大学歯学部　（新潟県新潟市）
- Year and Date
  2016-11-05
- Data Source
  KAKENHI-PROJECT-15K11382
[Presentation] 歯周炎罹患歯肉組織におけるネプリライシンの遺伝子発現レベルと免疫組織局在の解析2016
- Author(s)
  根津新、久保田健彦、丸山智、永田昌毅、堀水慎、濃野要、保苅崇大、両角俊哉、朔敬、吉江弘正
- Organizer
  平成28年度新潟歯学会第2回例会
- Place of Presentation
  新潟大学歯学部（新潟県新潟市）
- Data Source
  KAKENHI-PROJECT-26463132
[Presentation] Combinational perio-regenerative therapy with/without collagen membrane -A split mouth-2016
- Author(s)
  Kubota T, Nemoto Y, Nouno K, Morozumi T, Nezu A, Yoshie H
- Organizer
  The 102nd Annual Meeting of the American Academy of Periodontology in collaboration with the Japanese Society of Periodontology and Japanese Academy of Clinical Periodontology
- Place of Presentation
  San Diego Convention Center (San Diego, CA, U.S.A.)
- Year and Date
  2016-09-10
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26463132
[Presentation] Effectiveness of collagen membrane in combinational periodontal regenerative therapy.2016
- Author(s)
  Nemoto Y, Kubota T, Nouno K, Morozumi T, Nezu A, Yoshie H
- Organizer
  The 102nd Annual Meeting of the American Academy of Periodontology in collaboration with the Japanese Society of Periodontology and Japanese Academy of Clinical Periodontology
- Place of Presentation
  San Diego Convention Center (San Diego, CA, U.S.A.)
- Year and Date
  2016-09-10
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26463132
[Presentation] 歯周病・歯周治療に対する疑問に答えるー明日から役立つー　歯周基本治療・歯周再生治療・インプラント・全身疾患2016
- Author(s)
  久保田健彦
- Organizer
  2016　群馬県藤岡市歯科医師会学術講演会
- Place of Presentation
  藤岡商工会議所　(群馬県藤岡市）
- Year and Date
  2016-01-30
- Invited
- Data Source
  KAKENHI-PROJECT-15K11382
[Presentation] 歯周病・歯周治療に対する疑問に答えるー明日から役立つー　歯周基本治療・歯周再生治療・インプラント・全身疾患2016
- Author(s)
  久保田健彦
- Organizer
  群馬県藤岡市歯科医師会学術講演会
- Place of Presentation
  藤岡商工会議所　（群馬県藤岡市）
- Year and Date
  2016-01-30
- Invited
- Data Source
  KAKENHI-PROJECT-24593119
[Presentation] 広汎型重度慢性歯周炎患者においてOne-stage Full-mouth SRPと歯周組織再生療法により改善を認めた一症例2016
- Author(s)
  両角俊哉，久保田健彦，保苅崇大，奥田一博，吉江弘正
- Organizer
  第59回秋季日本歯周病学会学術大会
- Place of Presentation
  朱鷺メッセ（新潟県新潟市）
- Year and Date
  2016-10-07
- Data Source
  KAKENHI-PROJECT-26463132
[Presentation] Expression of neprilysin in periodontitis-affected gingival tissue2016
- Author(s)
  Nezu A, Kubota T, Maruyama S, Nagata M, Horimizu M, Nohno K, Hokari T, Morozumi T, Saku T, Yoshie H
- Organizer
  102th Annual Meeting of the American Academy of Periodontology
- Place of Presentation
  San Diego Convention Center, San Diego, CA (USA)
- Year and Date
  2016-10-10
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K11382
[Presentation] Biological effects of a-PDT and LDDS in chronic periodontitis2016
- Author(s)
  Hokari T, Morozumi T, Komatsu Y, Yoshino T, Shimizu T, Tanaka M, Tanaka Y, Kubota T, Yoshie H
- Organizer
  The 102nd Annual Meeting of the American Academy of Periodontology in collaboration with the Japanese Society of Periodontology and Japanese Academy of Clinical Periodontology
- Place of Presentation
  San Diego Convention Center (San Diego, CA, U.S.A.)
- Year and Date
  2016-09-10
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26463132
[Presentation] Alzheimer’s diseases-related gene and protein expressions in periodontitis-affected gingival tissues2015
- Author(s)
  Kubota T, Nezu A, Maruyama S, Horimizu M, Nohno K, Hokari T, Morozumi T, Saku T, Yoshie H
- Organizer
  Europerio 8
- Place of Presentation
  London (UK)
- Year and Date
  2015-06-03
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K11382
[Presentation] 慢性歯周炎に対する抗菌的光線力学療法と局所薬物配送システムの微生物学的および臨床的効果2015
- Author(s)
  保苅崇大, 両角俊哉, 吉野敏明, 小松康高, 田中真喜, 清水太郎, 田中良枝, 久保田健彦,吉江弘正
- Organizer
  第142回日本歯科保存学会2015年度春季学術大会
- Place of Presentation
  北九州国際会議場（福岡県北九州市）
- Year and Date
  2015-06-25
- Data Source
  KAKENHI-PROJECT-26463132
[Presentation] Alzheimer’s diseases-related gene and protein expressions in periodontitis-affected gingival tissues2015
- Author(s)
  Kubota T, Nezu A, Maruyama S, Horimizu M, Nohno K, Hokari T, Morozumi T, Saku T, Yoshie H
- Organizer
  Europerio 8
- Place of Presentation
  London , UK
- Year and Date
  2015-06-03
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-24593119
[Presentation] 歯周炎罹患歯肉組織におけるNeprilysin（Alzheimer病関連遺伝子）の発現2015
- Author(s)
  根津新、久保田健彦、丸山智、永田昌毅、堀水慎、濃野要、保苅崇大、両角俊哉、朔敬、吉江弘正
- Organizer
  第58回秋季日本歯周病学会学術大会
- Place of Presentation
  アクトシティ浜松　(静岡県浜松市）
- Year and Date
  2015-09-12
- Data Source
  KAKENHI-PROJECT-15K11382
[Presentation] Microbiological and clinical effect of antimicrobial photo dynamic therapy in choronic periodontitis patients2015
- Author(s)
  Morozumi T, Hokari T, Yoshino T, Komatsu Y, Tanaka M, Shimizu T, Tanaka Y, Kubota T, Yoshie H
- Organizer
  11th Asian Pacific Society of Periodontology Meeting
- Place of Presentation
  Discovery Hotel (Bali, Indonesia)
- Year and Date
  2015-10-08
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26463132
[Presentation] 歯周炎罹患歯肉組織におけるNeprilysin（Alzheimer病関連遺伝子）の発現2015
- Author(s)
  根津新、久保田健彦、丸山智、永田昌毅、堀水慎、濃野要、保苅崇大、両角俊哉、朔敬、吉江弘正
- Organizer
  第58回秋季日本歯周病学会学術大会
- Place of Presentation
  アクトシティ浜松　（静岡県浜松市）
- Year and Date
  2015-09-12
- Data Source
  KAKENHI-PROJECT-24593119
[Presentation] Amyloid beta (A4) precursor protein expression in periodontitis-affected gingival tissues2012
- Author(s)
  Kubota T, Mauyama S, Abe D, Shimizu T, Nakasone N, Morozumi T, Saku T, Yoshie H
- Organizer
  The 98th Annual Meeting American Academy of Periodontology in collaboration with the Japanese Society of Periodontology (Research Forum Poster Session)
- Place of Presentation
  Los Angeles, U.S.A.
- Data Source
  KAKENHI-PROJECT-24593119
[Presentation] アルツハイマー病関連遺伝子は歯周炎罹患歯肉において転写発現亢進している2010
- Author(s)
  久保田健彦、阿部大輔、清水太郎、中曽根直弘、両角俊哉、吉江弘正
- Organizer
  第53回秋季日本歯周病学会学術大会
- Place of Presentation
  高松市
- Year and Date
  2010-09-19
- Data Source
  KAKENHI-PROJECT-21592622
[Presentation] ACE及びTIMP-3の薬物性歯肉増殖症と歯周炎の歯肉組織における遺伝子発現とタンパク質局在2010
- Author(s)
  冨田尊志、久保田健彦、中曽根直弘、飯山真奈美、両角俊哉、永田昌毅、堀水慎、濃野要、吉江弘正
- Organizer
  第54回秋季日本歯周病学会学術大会
- Place of Presentation
  下関市
- Year and Date
  2010-09-24
- Data Source
  KAKENHI-PROJECT-21592622
[Presentation] Alzheimer's disease pathway was accelerated in periodontitis-affectedgingival tissues2010
- Author(s)
  Kubota T.Abe D, Shimizu T, Nakalone N, Morozumi T, Yoshie H
- Organizer
  IADR 88^<th> General Session 2010
- Place of Presentation
  Barcelona, Spain
- Data Source
  KAKENHI-PROJECT-21592622
[Presentation] Alzheimer's disease pathway was accelerated in periodontitis-affected gingival tissues2010
- Author(s)
  Kubota T, Abe D, Shimizu T, Nakasone N, Morozumi T, Yoshie H
- Organizer
  IADR 88th General Session 2010
- Place of Presentation
  Barcelona, Spain
- Data Source
  KAKENHI-PROJECT-21592622
[Presentation] 薬剤性歯肉増殖症の感受性と特異的遺伝子発現の網羅的解析2009
- Author(s)
  清水太郎、久保田健彦、阿部大輔、両角俊哉、中曽根直弘、吉江弘正
- Organizer
  第52回春季日本歯周病学会学術大会
- Place of Presentation
  岡山市
- Data Source
  KAKENHI-PROJECT-21592622
[Presentation] Transcriptomes in sites with drug-induced gingival-overgrowth Microarray and qRT-PCR analyses2009
- Author(s)
  Shimizu T, Kubota T, Abe D, Morozumi T, Nakasone N, Yoshie H
- Organizer
  EUROPERIO6
- Place of Presentation
  Stockholm, Sweden
- Data Source
  KAKENHI-PROJECT-21592622
[Presentation] Microbiological and clinical effect of antimicrobial photo dynamic therapy in choronic periodontitis patients.
- Author(s)
  Morozumi T, Hokari T, Yoshino T, Komatsu Y, Tanaka M, Shimizu T, Tanaka Y, Kubota T, Yoshie H
- Organizer
  11th Asian Pacific Society of Periodontology Meeting
- Place of Presentation
  Discovery Hotel (Bali, Indonesia)
- Year and Date
  2015-10-08 – 2015-10-09
- Data Source
  KAKENHI-PROJECT-26463132

1. YOSHIE Hiromasa (20143787)

# of Collaborated Projects: 4 results

# of Collaborated Products: 1 results
2. MARUYAMA Satoshi (30397161)

# of Collaborated Projects: 3 results

# of Collaborated Products: 11 results
3. KOBAYASHI Tetsuo (00215344)

# of Collaborated Projects: 2 results

# of Collaborated Products: 1 results
4. NAKASONE Naohiro (20447634)

# of Collaborated Projects: 2 results

# of Collaborated Products: 13 results
5. NOUNO Kaname (80422608)

# of Collaborated Projects: 2 results

# of Collaborated Products: 5 results
6. KOMATSU Yasutaka (40422597)

# of Collaborated Projects: 2 results

# of Collaborated Products: 8 results
7. NARITA Ichiei (20272817)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. MOROZUMI TOSHIYA (20444151)

# of Collaborated Projects: 1 results

# of Collaborated Products: 20 results
9. HOSHINA Hideyuki (30173587)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
10. NAGATA Masaki (10242439)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
11. FUJITA Hajime (60271805)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
12. TAKAGI Rituo (20143795)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
13. SHINGAKI Susumu (30134943)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
14. 山本幸司 (00397142)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
15. 清水太郎 (60609121)

# of Collaborated Projects: 1 results

# of Collaborated Products: 7 results
16. ABE Tatsuya

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
17. 朔敬

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

KUBOTA Takehiko 久保田 健彦

Research Projects

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Co-Researchers

Gene network analyses of AD in periodontitis-affected gingival tissuePrincipal Investigator

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Biological responses due to bacteremia following scaling and application effects of optical energy

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Elevated expression of Alzheimer disease related genes in periodontiti-affected gingival tissuesPrincipal Investigator

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The role of interleukin-6 epigenetics in the pathogenesis of periodontitis and rheumatoid arthritis

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Pathological roles of tissue inhibitors of metalloproteinases in the tissues of drug-induced fibrous gingival over growth.Principal Investigator

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RNA and protein expression based on risk gene polymorphisms in periodontitis and collagen diseases

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2G allile of MMP-1 gene polymorphism increases risk of oral cancer

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MMPの転写促進活性を有する遺伝子多型は歯周病のリスクファクターになりうるか?Principal Investigator

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禁煙によるヒト好中球遺伝子発現の変化

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早期発症型歯周炎患者に特異的な好中球遺伝子発現

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[Book] 歯周組織再生と歯根膜.歯界展望別冊「歯と歯列を守るための歯根膜活用術」2011

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[Book] 歯周組織再生と歯根膜.歯界展望別冊「歯と歯列を守るための歯根膜活用術」2011

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[Journal Article] 歯周炎歯肉組織局所の細胞外マトリックス代謝調節遺伝子発現解析と全身疾患の関連解明2018

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[Journal Article] Clinical and cone-beam CT evaluation of combinational periodontal regenerative therapies using enamel matrix derivative and deproteinized bovine bone mineral with or without collagen membrane2018

Author(s)

Journal Title

KUBOTA Takehiko 久保田健彦