Tozuka Yuichi 戸塚裕一

… Alternative Names

戸塚裕一トヅカユウイチ

TOZUKA Yuichi 戸塚裕一

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Researcher Number	50312963
Other IDs
External Links
Affiliation (Current)	2025: 大阪医科薬科大学, 薬学部, 教授 2025: 岐阜薬科大学, 薬学部, 准教授
Affiliation (based on the past Project Information) *help	2021 – 2023: 大阪医科薬科大学, 薬学部, 教授 2018 – 2020: 大阪薬科大学, 薬学部, 教授 2012 – 2015: 大阪薬科大学, 薬学部, 教授 2009 – 2011: 岐阜薬科大学, 薬学部, 准教授 2007: Gifu Pharmaceutical University, 薬学部, 准教授 … More 2006: 岐阜薬科大学, 薬学部, 助教授 2005: 千葉大学, 大学院・薬学研究院, 助手 2002: 千葉大学, 大学院・薬学研究科, 助手 2001 – 2002: 千葉大学, 大学院・薬学研究院, 助手 2000: 千葉大学, 薬学部, 助手 Less
Review Section/Research Field	Principal Investigator Basic Section 47020:Pharmaceutical analytical chemistry and physicochemistry-related / Physical pharmacy / Integrated Nutrition Science Except Principal Investigator Basic Section 47060:Clinical pharmacy-related / Physical pharmacy / Physical pharmacy
Keywords	Principal Investigator 糖転移ルチン / ナノコンポジット / 難水溶性化合物 / 溶解度改善 / 糖転移ナリンジン / 糖転移ステビア / 糖転移へスぺリジン / ナノ集合体 / 吸収性改善 / 溶解性改善 … More / 分子間相互作用 / 肺深部到達性 / 粒子形態制御 / 粒子設計 / リファンピシン / 噴霧凍結乾燥法 / デキストラン / マトリックス / フィトグリコーゲン / 実験計画法 / 噴霧乾燥法 / コンポジット粒子 / 吸入粉末剤 / 粉砕補助剤 / 処方設計 / 複合体形成 / 可溶化 / 糖転移ヘスペリジン / 光安定性向上 / 機能性粒子 / 難水溶性薬物 / 糖転移化合物 / 機能性添加剤 / 製剤学 / 固体NMR / 混合粉砕 / 多変量解析 / ナノ微粒子 / メカノケミストリー / ニューロファジィ / ビルドアップ / ブレイクダウン / ニューラルネットワーク / シクロデキストリン / エマルション溶媒拡散法 / ナノ粒子 / 超臨界二酸化炭素 / 最適処方 / データマイニング … More Except Principal Investigator コアモルファス / モルフォロジー / モダリティ / 噴霧乾燥法 / in silico / 吸入粉末剤 / 吸入粉末合剤 / ナノ粒子 / 形態解析 / 凍結噴霧乾燥法 / 共結晶 / 中分子 / 難吸収性 / 難溶解性 / 中分子化合物 / CYP / アモルファス / 経口吸収性改善 / 溶解性改善 / Particle Size / Crystallinity / Micronisation / Particle Design / Supercritical Fluid / 微細化 / 固体分散系 / 補集 / 粒子径 / 結晶性 / 微粉化 / 粉末医薬品 / 超臨界流体 / ペプチド / ステロイド / 抗炎症薬 / 経肺投与 / リモートローディング / 微粒子 / 点眼剤 / 網膜 / 局所体内挙動 / リポソーム / 製剤学 Less

Building foundation of developing in silico technology-driven dry powder inhaler formulation applicable to drug modality
- Principal Investigator
  
  門田和紀
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 47060:Clinical pharmacy-related
- Research Institution
  Osaka Medical and Pharmaceutical University
A redesigned pulmonary formulation platform: Preparation of carrier particles with advanced alveolar transportabilityPrincipal Investigator
- Principal Investigator
  
  Tozuka Yuichi
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 47020:Pharmaceutical analytical chemistry and physicochemistry-related
- Research Institution
  Osaka Medical and Pharmaceutical University
Construction of drug development strategies for middle-molecule drug with low solubility and absorption based on coamorphous formation
- Principal Investigator
  
  Hiromasa Uchiyama
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 47060:Clinical pharmacy-related
- Research Institution
  Osaka Medical and Pharmaceutical University
  Osaka University of Pharmaceutical Sciences
Hybrid formulations of the organic nanocomposite via structural investigationsPrincipal Investigator
- Principal Investigator
  
  Tozuka Yuichi
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 47020:Pharmaceutical analytical chemistry and physicochemistry-related
- Research Institution
  Osaka University of Pharmaceutical Sciences
The use of functional nanocomposite structure for the development of novel functional food for specified health usesPrincipal Investigator
- Principal Investigator
  
  TOZUKA YUICHI
- Project Period (FY)
  2013 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Integrated Nutrition Science
- Research Institution
  Osaka University of Pharmaceutical Sciences
Nano-composite formation for various pharmaceutical formulations.Principal Investigator
- Principal Investigator
  
  TOZUKA Yuichi
- Project Period (FY)
  2010 – 2012
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Physical pharmacy
- Research Institution
  Osaka University of Pharmaceutical Sciences
  Gifu Pharmaceutical University
Novel Dosage form design for ocular and pulmonary drug delivery based on analysis of behavior of nano-particle as drug carrier
- Principal Investigator
  
  TAKEUCHI Hirofumi
- Project Period (FY)
  2009 – 2011
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Physical pharmacy
- Research Institution
  Gifu Pharmaceutical University
データマイニング法のナノ製剤開発への応用検討Principal Investigator
- Principal Investigator
  
  戸塚裕一
- Project Period (FY)
  2005 – 2007
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Physical pharmacy
- Research Institution
  Gifu Pharmaceutical University
  Chiba University
Characterization for Pharmaceutical Solid Dispersion Prepared by means of Supercritical Carbon Dioxide
- Principal Investigator
  
  OGUCHI Toshio
- Project Period (FY)
  2000 – 2002
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Physical pharmacy
- Research Institution
  University of Yamanashi, Faculty of Medicine
  Chiba University

[Book] 医薬品におけるDDS技術と製剤開発への応用2021
- Author(s)
  戸塚裕一、門田和紀　他多数
- Total Pages
  401
- Publisher
  情報機構
- Data Source
  KAKENHI-PROJECT-21K06504
[Book] くすりに学ぶナノ粒子・ナノカプセルの作り方.「究極のかたちをつくる」2009
- Author(s)
  竹内洋文, 戸塚裕一
- Publisher
  日刊工業新聞社
- Data Source
  KAKENHI-PROJECT-21390011
[Journal Article] Tuning the Phytoglycogen Size and Aggregate Structure with Solvent Quality: Influence of Water?Ethanol Mixtures Revealed by X-ray and Light Scattering Techniques2023
- Author(s)
  Kamarainen Tero、Kadota Kazunori、Tse Jun Y.、Uchiyama Hiromasa、Oguchi Toshio、Arima-Osonoi Hiroshi、Tozuka Yuichi
- Journal Title
  
  Biomacromolecules
  
  Volume: 24 Issue: 1 Pages: 225-237
- DOI
  10.1021/acs.biomac.2c01093
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21K06504
[Journal Article] Improvement in Inhalation Properties of Theophylline and Levofloxacin by Co-Amorphization and Enhancement in Its Stability by Addition of Amino Acid as a Third Component2023
- Author(s)
  Ueda Hiroshi、Hirakawa Yuya、Miyano Tetsuya、Nakayama Yuzuki、Hatanaka Yuta、Uchiyama Hiromasa、Tozuka Yuichi、Kadota Kazunori
- Journal Title
  
  Molecular Pharmaceutics
  
  Volume: 20 Issue: 12 Pages: 6368-6379
- DOI
  10.1021/acs.molpharmaceut.3c00756
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23K06245
[Journal Article] Effect of Solubility Improvement <i>via</i> Formation of an Amorphous Composite of Indomethacin and Sulindac on Membrane Permeability2023
- Author(s)
  Yuta Hatanaka, Hiromasa Uchiyama, Shingo Furukawa, Mai Takase, Shinya Yamanaka, Kazunori Kadota, Yuichi Tozuka
- Journal Title
  
  Chemical and Pharmaceutical Bulletin
  
  Volume: 71 Issue: 3 Pages: 257-261
- DOI
  10.1248/cpb.c22-00847
- ISSN
  0009-2363, 1347-5223
- Year and Date
  2023-03-01
- Language
  English
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K07191
[Journal Article] The formation of an amorphous composite between flavonoid compounds: Enhanced solubility in both oil components and aqueous media2022
- Author(s)
  Hiromasa Uchiyama, Taiga Ando, Kazunori Kadota, Yuichi Tozuka
- Journal Title
  
  Journal of Drug Delivery Science and Technology
  
  Volume: 62 Pages: 102410-102410
- DOI
  10.1016/j.jddst.2021.102410
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K07191
[Journal Article] Modulating Pore Space Architecture of Ice-Templated Dextran Microparticles Using Molecular Weight and Concentration2022
- Author(s)
  T. Kamarainen, K. Kadota, J. Y. Tse, H. Uchiyama, S. Yamanaka, Y. Tozuka
- Journal Title
  
  Langmuir
  
  Volume: 38 Issue: 21 Pages: 6741-6751
- DOI
  10.1021/acs.langmuir.2c00721
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21K06504, KAKENHI-PROJECT-20K07212
[Journal Article] Porous particles and novel carrier particles with enhanced penetration for efficient pulmonary delivery of antitubercular drugs2021
- Author(s)
  Tse Jun Yee、Koike Atsushi、Kadota Kazunori、Uchiyama Hiromasa、Fujimori Ko、Tozuka Yuichi
- Journal Title
  
  European Journal of Pharmaceutics and Biopharmaceutics
  
  Volume: 167 Pages: 116-126
- DOI
  10.1016/j.ejpb.2021.07.017
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20K07212, KAKENHI-PROJECT-21K06504
[Journal Article] Improved solubility and permeability of both nifedipine and ketoconazole based on coamorphous formation with simultaneous dissolution behavior2021
- Author(s)
  Yuta Hatanaka, Hiromasa Uchiyama, Kazunori Kadota, Yuichi Tozuka
- Journal Title
  
  Journal of Drug Delivery Science and Technology
  
  Volume: 65 Pages: 102715-102715
- DOI
  10.1016/j.jddst.2021.102715
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K07191
[Journal Article] Improved water dispersibility and photostability in folic acid nanoparticles with transglycosylated naringin using combined processes of wet-milling and freeze-drying2019
- Author(s)
  K. Semba, K. Kadota, H. Arima, A. Nakanishi, M. Tandia, H. Uchiyama, K. Sugiyama, Y. Tozuka
- Journal Title
  
  Food Res. Int.
  
  Volume: 121 Pages: 108-116
- DOI
  10.1016/j.foodres.2019.03.034
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K06614
[Journal Article] A simple blending with α-glycosylated naringin produce the enhancement of solubility and absorption of pranlukast hemihydrate2019
- Author(s)
  H. Uchiyama, K. Kadota, A. Nakanishi, M. Tandia, Y. Tozuka
- Journal Title
  
  Int. J. Pharm.
  
  Volume: 567 Pages: 118490-118490
- DOI
  10.1016/j.ijpharm.2019.118490
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K06614
[Journal Article] Mixed micelles of the drug diphenhydramine hydrochloride with anionic and non-ionic surfactants show improve solubility, drug release and cytotoxicity of ethenzamide2019
- Author(s)
  A. Srivastava, H. Uchiyama, Y. Wada, Y. Hatanaka, Y. Shirakawa, K. Kadota, Y. Tozuka
- Journal Title
  
  J. Mol. Liq.
  
  Volume: 277 Pages: 349-359
- DOI
  10.1016/j.molliq.2018.12.070
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K06614
[Journal Article] Enhanced solubility and permeability of quercetin by composite formation between α-glucosyl stevia and hydrophilic polymer2019
- Author(s)
  H. Uchiyama, Y. Wada, Y. Hatanaka, Y. Hirata, M. Taniguchi, A. Nakanishi, M. Tandia, K. Kadota, Y. Tozuka
- Journal Title
  
  J. Pharm. Sci.
  
  Volume: 108 Issue: 6 Pages: 2033-2040
- DOI
  10.1016/j.xphs.2019.01.007
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K06614, KAKENHI-PROJECT-19K05775
[Journal Article] Investigation of physiological properties of transglycosylated stevia with cationic surfactant and its application to enhance the solubility of rebamipide2018
- Author(s)
  H. Uchiyama, A. Srivastava, M. Fujimori, K. Tomoo, A. Nakanishi, M. Tandia, K. Kadota, Y. Tozuka
- Journal Title
  
  J. Phys. Chem. B
  
  Volume: 122 Issue: 43 Pages: 10051-10061
- DOI
  10.1021/acs.jpcb.8b07515
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K06614
[Journal Article] Jelly containing composite based on α-glucosyl stevia and polyvinylpyrrolidone: Improved dissolution property of curcumin2018
- Author(s)
  H. Uchiyama, S. Nogami, K. Katayama, K. Hayashi, K. Kadota, Y. Tozuka
- Journal Title
  
  Euro. J. Pharm.Sci
  
  Volume: 117 Pages: 48-54
- DOI
  10.1016/j.ejps.2018.02.011
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K06614
[Journal Article] Emergent composite structures following the amorphization of itraconazole with transglycosylated rutin by over-grinding2018
- Author(s)
  K. Kadota, H. Arima, R. Shakudo, K. Semba, H. Uchiyama, K. Sugiyama, Y. Tozuka
- Journal Title
  
  Powder Technol
  
  Volume: 323 Pages: 69-75
- DOI
  10.1016/j.powtec.2017.10.002
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K06614
[Journal Article] Low hygroscopic spray-dried powders with trans-glycosylated food additives for enhanced solubility and oral bioavailability of a ipriflavone2016
- Author(s)
  M. Fujimori, K. Kadota, K. Kato, Y. Seto, S. Onoue, H. Sato, H. Ueda, Y. Tozuka
- Journal Title
  
  Food. Chem.
  
  Volume: 190 Pages: 1050-1055
- DOI
  10.1016/j.foodchem.2015.06.081
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-25504018
[Journal Article] Inhibited photodegradation of highly-dispersed folic acid nanoparticles by antioxidant effect of transglycosylated rutin2016
- Author(s)
  K. Kadota, K. Semba, R. Shakudo, H. Sato, Y. Deki, Y. Shirakawa, Y. Tozuka
- Journal Title
  
  J. Agr. Food. Chem.
  
  Volume: 64 Issue: 15 Pages: 3062-3069
- DOI
  10.1021/acs.jafc.6b00334
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-25504018
[Journal Article] Soluble hydrolysis-resistant composite formulation of curcumin containing α-glucosyl hesperidin and polyvinylpyrrolidone2016
- Author(s)
  K. Kadota, S. Otsu, M. Fujimori, H. Sato, Y. Tozuka
- Journal Title
  
  Adv. Powder Tech.
  
  Volume: 27 Issue: 2 Pages: 442-447
- DOI
  10.1016/j.apt.2016.01.012
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-25504018
[Journal Article] Absorption improvement of tranilast by forming highly soluble nano-size composite structures associated with α-glucosyl rutin2015
- Author(s)
  H. Sato, M. Fujimori, H. Suzuki, K. Kadota, Y. Shirakawa, S. Onoue, Y. Tozuka
- Journal Title
  
  Euro. J. Pharm. Biopharm.
  
  Volume: 92 Pages: 49-55
- DOI
  10.1016/j.ejpb.2015.02.021
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-25504018
[Journal Article] Enhanced dissolution of quercetin by forming composite particles2015
- Author(s)
  M. Fujimori, K. Kadota, K. Shimono, Y Shirakawa, H. Sato, Y. Tozuka
- Journal Title
  
  J. Food Eng.
  
  Volume: 149 Pages: 248-254
- DOI
  10.1016/j.jfoodeng.2014.10.010
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-25504018
[Journal Article] Drug solubilization mechanism of alpha-glucosyl stevia by NMR spectroscopy2014
- Author(s)
  Zhang, J., Higashi, K., Ueda, K., Kadota, K., Tozuka, Y., Limwikrant, W., Yamamoto, K., Moribe, K.
- Journal Title
  
  Int. J. Pharm.
  
  Volume: 465 (1-2) Issue: 1-2 Pages: 255-261
- DOI
  10.1016/j.ijpharm.2014.01.035
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-14J03968, KAKENHI-PROJECT-24790041, KAKENHI-PROJECT-25504018
[Journal Article] Transglycosylated Rutin-Specific Non-Surface-Active Nanostructure Affects Absorption Enhancement of Flurbiprofen, Euro2012
- Author(s)
  Y. Tozuka, K. Higashi, T. Morita, M.Nishikawa, H. Uchiyama, J. Zhang, K. Moribe, K. Nishikawa, H. Takeuchi, K. Yamamoto
- Journal Title
  
  J. Pharm. Biopharm
  
  Volume: 82 Pages: 120-126
- Data Source
  KAKENHI-PROJECT-22790041
[Journal Article] Pulmonary delivery of elcatonin using surface-modified liposomes to improve systemic absorption : polyvinyl alcohol with a hydrophobic anchor and chitosan oligosaccharide as effective surface modifiers2012
- Author(s)
  Murata M, Nakano K, Tahara K, Tozuka Y, Takeuchi H
- Journal Title
  
  Eur J Pharm Biopharm
  
  Volume: 80 Issue: 2 Pages: 340-346
- DOI
  10.1016/j.ejpb.2011.10.011
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21390011
[Journal Article] Transglycosylated Rutin-Specific Non-Surface-Active Nanostructure Affects Absorption Enhancement of Flurbiprofen2012
- Author(s)
  Yuichi Tozuka
- Journal Title
  
  European Journal of Pharmaceutics and Biopharmaceutics
  
  Volume: 82 Issue: 1 Pages: 120-126
- DOI
  10.1016/j.ejpb.2012.05.005
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22790041, KAKENHI-PROJECT-24590045
[Journal Article] Nanocomposite FormationBetween Alpha-glucosyl Stevia and Surfactant Improves the Dissolution Profile of Poorly Water-Soluble Drug, Int2012
- Author(s)
  H. Uchiyama, Y. Tozuka, M. Nishikawa, H. Takeuchi
- Journal Title
  
  J. Pharm
  
  Volume: 428 Pages: 183-186
- Data Source
  KAKENHI-PROJECT-22790041
[Journal Article] α-Glucosyl Hesperidin Induced Improvement in Bioavailability of Pranlukast Hemihydrate Using High-Pressure Homogenization, Int2011
- Author(s)
  H. Uchiyama, Y. Tozuka, F. Asamato, H.Takeuchi
- Journal Title
  
  J. Pharm
  
  Volume: 410 Pages: 114-117
- Data Source
  KAKENHI-PROJECT-22790041
[Journal Article] Fluorescence Investigation of the Retinal Delivery of Hydrophilic Compounds via Liposomal Eyedrops2011
- Author(s)
  Hironaka K.
- Journal Title
  
  Biological and Pharmaceutical Bulletin
  
  Volume: 34 Issue: 6 Pages: 894-897
- DOI
  10.1248/bpb.34.894
- NAID
  130000738067
- ISSN
  0918-6158, 1347-5215
- Language
  English
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-11J00384, KAKENHI-PROJECT-21390011
[Journal Article] Edaravone-loaded liposomes for retinal protection against oxidative stress-induced retinal damage2011
- Author(s)
  Hironaka K.
- Journal Title
  
  European Journal of Pharmaceutics and Biopharmaceutics
  
  Volume: Vol.79 Issue: 1 Pages: 119-125
- DOI
  10.1016/j.ejpb.2011.01.019
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-11J00384, KAKENHI-PROJECT-21390011
[Journal Article] Edaravone-loaded liposome eyedrops protect against light-induced retinal damage in mice2011
- Author(s)
  Shimazaki H, Hironaka K
- Journal Title
  
  Investigative Ophthalmology & Visual Science
  
  Volume: Vol.34 Issue: 10 Pages: 7289-7297
- DOI
  10.1167/iovs.11-7983
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-11J00384, KAKENHI-PROJECT-21390011
[Journal Article] NMR Investigation of a Novel Excipient, α-Glicosylhesperidin as a Suitable Solubilizing Agent for Poorly Water-Soluble Drugs2011
- Author(s)
  J. Zhang, Y. Tozuka, H. Uchiyama, K.Higashi, K. Moribe, H. Takeuchi, K.Yamamoto
- Journal Title
  
  J. Pharm. Sci
  
  Volume: 100 Pages: 4421-4431
- Data Source
  KAKENHI-PROJECT-22790041
[Journal Article] A Novel Application of α-Glucosyl Hesperidin for Nanoparticle Formation of Active Pharmaceutical Ineredient by Dry-Grinding2011
- Author(s)
  Y.Tozuka, M.Imono, H.Uchiyama, H.Takeuchi
- Journal Title
  
  European journal of pharmaceutics and biopharm aceutics
  
  Volume: 79 Issue: 3 Pages: 559-565
- DOI
  10.1016/j.ejpb.2011.07.006
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22790041
[Journal Article] NMR investigation of a novel excipient, α-glucosylhesperidin, as a suitable solubilizing agent for poorly water-soluble drugs2011
- Author(s)
  J.Zhang, Y.Tozuka, H.Uchiyama, K.Higashi, K.Moribe, H.Takeuchi, K.Yamamoto
- Journal Title
  
  J.Pharm.Sci
  
  Volume: 100 Issue: 10 Pages: 4421-4431
- DOI
  10.1002/jps.22606
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590038, KAKENHI-PROJECT-22790041
[Journal Article] Fluorescence Investigation of a Specific Structure Formed by Aggregation of Transglycosylated Stevias : Solubilizing Effect of Poorly Water-Soluble Drugs2011
- Author(s)
  H.Uchiyama, Y.Tozuka, F.Asamato, H.Takeuchi
- Journal Title
  
  European journal of pharmaceutical sciences
  
  Volume: 43 Issue: 1-2 Pages: 71-77
- DOI
  10.1016/j.ejps.2011.03.014
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22790041
[Journal Article] Fluorescence Investigation of a Specific Structure Formed by Aggregation of Transglycosylated Stevias: Solubilizing Effect of Poorly Water-Soluble Drugs2011
- Author(s)
  H. Uchiyama, Y. Tozuka, F. Asamato, H.Takeuchi
- Journal Title
  
  Euro. J. Pharm. Sci
  
  Volume: 43 Pages: 71-77
- Data Source
  KAKENHI-PROJECT-22790041
[Journal Article] Transglycosylated Stevia and Hesperidin as Pharmaceutical Excipients : Dramatic Improvement in Drug Dissolution and Bioavailability2010
- Author(s)
  内山博雅、戸塚裕一、鋳物将明、竹内洋文
- Journal Title
  
  European journal of pharmaceutics and biopharm aceutics
  
  Volume: 76 Pages: 238-244
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22790041
[Journal Article] Improvement of Dissolution and Absorption Properties of Poorly Water-Soluble Drug by Preparing Spray-Dried Powders with α-Glucosyl Hesperidin2010
- Author(s)
  H. Uchiyama, Y. Tozuka, H. Imono, H.Takeuchi
- Journal Title
  
  Int. J. Pharm
  
  Volume: 392 Pages: 101-106
- Data Source
  KAKENHI-PROJECT-22790041
[Journal Article] Improvement of Dissolution and Absorption Properties of Poorly Water-Soluble Drug by Preparing Spray-Dried Powders with α-Glucosyl Hesperidin2010
- Author(s)
  内山博雅、戸塚裕一、鋳物将明、竹内洋文
- Journal Title
  
  International journal of pharmaceutics
  
  Volume: 392 Pages: 101-106
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22790041
[Journal Article] Nanoparticles of Glycol Chitosan and Its Thiolated Derivative Significantly Improved the Pulmonary Delivery of Calcitonin2010
- Author(s)
  Abdallah MAKHLOF, Martin WERLE, Yuichi TOZUKA, Hirofumi TAKEUCHI
- Journal Title
  
  Int. J. Pharm
  
  Volume: 397 Issue: 1-2 Pages: 92-95
- DOI
  10.1016/j.ijpharm.2010.07.001
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21390011
[Journal Article] Anomalous Dissolution PropertyEnhancement of Naringenin fromSpray-Dried Powders withα-Glucosylhesperidin2010
- Author(s)
  Y. Tozuka, J. Kishi, H. Takeuchi
- Journal Title
  
  Adv. Powder.Tech
  
  Volume: 21 Pages: 305-309
- Data Source
  KAKENHI-PROJECT-22790041
[Journal Article] Transglycosylated Stevia and Hesperidin as Pharmaceutical Excipients: Dramatic Improvement in Drug Dissolution and Bioavailability2010
- Author(s)
  H. Uchiyama, Y. Tozuka, H. Imono, H.Takeuchi
- Journal Title
  
  Euro J. Pharm. Biopharm
  
  Volume: 76 Pages: 238-244
- Data Source
  KAKENHI-PROJECT-22790041
[Journal Article] Nanoparticles of Glycol Chitosan and Its Thiolated Derivative Significantly Improved the Pulmonary Delivery of Calcitonin2010
- Author(s)
  Abdallah MAKHLOF, Martin WERLE, Yuichi TOZUKA, Hirofumi TAKEUCHI
- Journal Title
  
  Int.J Pharm.
  
  Volume: 397 Pages: 92-95
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21390011
[Journal Article] Design and evaluation of a liposomal delivery system targeting the posterior segment of the eye2009
- Author(s)
  K.Hironaka, Y.Inokuchi, Y.Tozuka, M.Shimazawa, H.Hara, H.Takeuchi
- Journal Title
  
  J.Control.Release 136
  
  Pages: 247-253
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21390011
[Journal Article] pH-sensitive nanospheres for colon-specfic drug delivery in experimentally induced colitis rat model2009
- Author(s)
  A.Makhlof, Y.Tozuka, H.Takeuchi
- Journal Title
  
  Eur.J.Pharm. Biopharm 72
  
  Pages: 1-8
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21390011
[Journal Article] Design and evaluation of a liposomal delivery system targeting the posterior segment of the eye2009
- Author(s)
  K. Hironaka, Y. Inokuchi, Y. Tozuka, M. Shimazawa, H. Hara, H. Takeuchi
- Journal Title
  
  J. Control. Rel
  
  Volume: 136 Issue: 3 Pages: 247-253
- DOI
  10.1016/j.jconrel.2009.02.020
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21390011
[Journal Article] Application of Ascorbic Acid 2-glucoside as a Solubilizing Agent for Clarithromycin : Solubilization and Nanoparticle Formation2007
- Author(s)
  Y.Inoue, S.Yoshimura, Y.Tozuka, K.Moribe, T.Kumamoto, T.Ishikawa, K.Yamamoto
- Journal Title
  
  International Journal of Pharmaceutics 331
  
  Pages: 38-45
- Data Source
  KAKENHI-PROJECT-17790029
[Journal Article] Preparation of Drug Nanoparticles by Co-grinding with Cyclodextrins : Formation Mechanism and Factors Affecting Nanoparticle Formation2007
- Author(s)
  A.Wongmekiat, Y.Tozuka, K.Moribe, T.Oguchi, K.Yamamoto
- Journal Title
  
  Chemical Pharmaceutical Bulletin 55
  
  Pages: 359-363
- NAID
  110006225080
- Data Source
  KAKENHI-PROJECT-17790029
[Patent] 水溶性組成物、その製造方法および難水溶性物質の溶解性改善方法2015
- Inventor(s)
  戸塚裕一, 門田和紀, 長井敦史, 相澤恭
- Industrial Property Rights Holder
  東洋精糖株式会社
- Industrial Property Rights Type
  特許
- Industrial Property Number
  2015-170659
- Filing Date
  2015-08-31
- Data Source
  KAKENHI-PROJECT-25504018
[Patent] α－グルコシルルチン含有プテリジン誘導体ナノ粒子の製造方法およびα－グルコシルルチン含有プテリジン誘導体ナノ粒子2015
- Inventor(s)
  門田和紀, 戸塚裕一, 長井敦史, 相澤恭
- Industrial Property Rights Holder
  東洋精糖株式会社
- Industrial Property Rights Type
  特許
- Industrial Property Number
  2015-152068
- Filing Date
  2015-07-31
- Data Source
  KAKENHI-PROJECT-25504018
[Patent] 難水溶性物質の溶解方法およびその利用2012
- Inventor(s)
  戸塚裕一, 内山博雅, 竹内洋文, 相澤恭、飯田純久
- Industrial Property Rights Holder
  東洋精糖株式会社
- Patent Publication Number
  2012-240949
- Acquisition Date
  2012-12-10
- Data Source
  KAKENHI-PROJECT-22790041
[Patent] 高吸収性薬剤組成物およびその製造方法2011
- Inventor(s)
  戸塚裕一, 内山博雅, 竹内洋文, 飯田純久, 米谷俊
- Industrial Property Rights Holder
  東洋精糖株式会社
- Patent Publication Number
  2011-051938
- Acquisition Date
  2011-03-17
- Data Source
  KAKENHI-PROJECT-22790041
[Patent] 微粒子2007
- Inventor(s)
  竹内洋文, 戸塚裕一, 宮崎雄太, 杉原光, 西浦昭雄
- Industrial Property Rights Holder
  小野薬品工業
- Filing Date
  2007-10-12
- Data Source
  KAKENHI-PROJECT-17790029
[Presentation] Carvedilolを含有した様々な粒子形態を持つSupraparticlesの作製2024
- Author(s)
  中山結月、Tero Kamarainen、内山博雅、門田和紀、戸塚裕一
- Organizer
  日本薬学会第144年会
- Data Source
  KAKENHI-PROJECT-23K06245
[Presentation] Telmisartan-Amlodipineコアモルファス形成による難溶性薬物の吸収性改善.2023
- Author(s)
  畑中友太、内山博雅、門田和紀、戸塚裕一
- Organizer
  日本薬学会第143年会
- Data Source
  KAKENHI-PROJECT-20K07191
[Presentation] 噴霧乾燥法による新規キャリア粒子による吸入粉末製剤の設計2022
- Author(s)
  門田和紀、謝晉頤、T. Kamarainen、内山博雅、戸塚裕一
- Organizer
  粉体工学会第 56 回技術討論会
- Data Source
  KAKENHI-PROJECT-21K06504
[Presentation] Image analysis routines toward pore characterization of spray freeze dried dextran microparticles2022
- Author(s)
  T. Kamarainen, H. Uchiyama, K. Kadota, Y. Tozuka
- Organizer
  粉体工学会第 56 回技術討論会
- Data Source
  KAKENHI-PROJECT-21K06504
[Presentation] 異なる分子間相互作用様式を持つ非晶質複合体粒子からの薬物の膜透過性に関する検討.2022
- Author(s)
  内山博雅、河合晴香、畑中友太、門田和紀、戸塚裕
- Organizer
  日本薬剤学会第37年会
- Data Source
  KAKENHI-PROJECT-20K07191
[Presentation] イオン間相互作用を介した非晶質複合体の薬物溶解度と膜透過性の関係性評価.2022
- Author(s)
  畑中友太、内山博雅、門田和紀、戸塚裕一
- Organizer
  日本薬剤学会第47年会製剤・創剤セミナー
- Data Source
  KAKENHI-PROJECT-20K07191
[Presentation] CYP3A4の阻害剤を基剤に用いたコアモルファス設計とその評価2022
- Author(s)
  畑中友太、内山博雅、門田和紀、戸塚裕一
- Organizer
  日本薬剤学会第37年会
- Data Source
  KAKENHI-PROJECT-20K07191
[Presentation] Aggregation of phytoglycogen in water-ethanol mixtures characterized by small-angle X-ray scattering and dynamic light scattering measurements, The 7th International Conference on the Characterization and Control of Interfaces for High Quality Advanced Materials2022
- Author(s)
  T. Kamarainen, K. Kadota, J.Y. Tse, H. Uchiyama, T. Oguchi, H. Arima-Osonoi, Y. Tozuka
- Organizer
  The 7th International Conference on the Characterization and Control of Interfaces for High Quality Advanced Materials
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K06504
[Presentation] Ice templated dextran microparticles by spray freeze drying: Influence of molecular weight and concentration2022
- Author(s)
  T. Kamarainen, J.Y. Tse, H. Uchiyama, K. Kadota, Y. Tozuka
- Organizer
  粉体工学会2022年度春期研究発表会シンポジウム
- Data Source
  KAKENHI-PROJECT-21K06504
[Presentation] 新規キャリア粒子による肺深部への高効率な到達性を実現した抗結核薬吸入粉末剤の設計2021
- Author(s)
  入船三奈子、謝晉頤、小池敦資、内山博雅、門田和紀、藤森功、戸塚裕一
- Organizer
  日本薬剤学会第36年会
- Data Source
  KAKENHI-PROJECT-21K06504
[Presentation] Composite spray freeze-dried particles for functional food with improved dissolution properties by enhanced water dispersibility2021
- Author(s)
  J. Y. Tse, G. Nemoto, H. Uchiyama, K. Kadota, Y. Tozuka
- Organizer
  8th Asian Particle Technology Symposium
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K06504
[Presentation] 膜透過性改善を指向したコアモルファス技術の構築とエマルションへの応用.2020
- Author(s)
  内山博雅、花本夕華、門田和紀、戸塚裕一
- Organizer
  70回日本薬学会関西支部会
- Data Source
  KAKENHI-PROJECT-20K07191
[Presentation] 機能性食品中に含有される難水溶性有効成分の可溶化技術：薬学研究の視点からの戦略2020
- Author(s)
  戸塚裕一
- Organizer
  第11回岐阜薬科大学機能性健康食品研究講演会
- Invited
- Data Source
  KAKENHI-PROJECT-18K06614
[Presentation] 分子間相互作用に基づく機能性粒子・ナノ集合体の調製と医薬品・食品産業への新規処方の提案2020
- Author(s)
  戸塚裕一
- Organizer
  令和2年度第2回メディショナルナノテク研究会
- Invited
- Data Source
  KAKENHI-PROJECT-18K06614
[Presentation] クルクミンゼリー剤の放出挙動に及ぼすテクスチャの影響2019
- Author(s)
  野上聡、内山博雅、門田和紀、戸塚裕一
- Organizer
  日本薬学会139年会
- Data Source
  KAKENHI-PROJECT-18K06614
[Presentation] 機能性食品開発を指向した湿式粉砕によるSilybinナノ粒子の調製2019
- Author(s)
  藤森美季、内山博雅、門田和紀、戸塚裕一
- Organizer
  製剤機械技術学会第29回大会
- Data Source
  KAKENHI-PROJECT-18K06614
[Presentation] 経口ゼリー剤のテクスチャに及ぼす添加塩の影響2019
- Author(s)
  野上聡、内山博雅、門田和紀、戸塚裕一
- Organizer
  日本海水学会第70年会
- Data Source
  KAKENHI-PROJECT-18K06614
[Presentation] α-Glucosyl Steviaを用いた混合ミセル形成による小腸環境下でのClotrimazoleの溶解性改善2019
- Author(s)
  木戸貴也、内山博雅、Anirudh Srivastava、門田和紀、戸塚裕一
- Organizer
  日本薬剤学会第34年会
- Data Source
  KAKENHI-PROJECT-18K06614
[Presentation] Investigation of mixed micelle formation between transglycosylated stevia and cationic surfactants with different carbon chain length2018
- Author(s)
  M. Fujimori, H. Uchiyama, K. Kadota, Y. Tozuka
- Organizer
  The 6th International Conference on the Characterization and Control of Interfaces (ICCCI2018) for High Quality Advanced Materials
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K06614
[Presentation] Preparation of jelly formulation with nano-composites structure containing curcumin2018
- Author(s)
  S. Nogami, H. Uchiyama, K. Hayashi, K. Kadota, Y. Tozuka
- Organizer
  The 2nd Workshop for Japan-Korea Young Scientists on Pharmaceutics
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K06614
[Presentation] 固体NMRによるcarbamazepine/α-glucosyl rutin非晶質固体分散体中の分子間相互作用の評価2018
- Author(s)
  東顕二郎、青木千咲、石塚優也、植田圭祐、門田和紀、戸塚裕一、森部久仁一
- Organizer
  日本薬剤学会第33年会
- Data Source
  KAKENHI-PROJECT-18K06614
[Presentation] 糖転移ステビアとポリビニルピロリドンのコンポジット形成によるケルセチンの溶解性改善2018
- Author(s)
  内山博雅、林圭太、門田和紀、戸塚裕一
- Organizer
  日本薬剤学会第33年会
- Data Source
  KAKENHI-PROJECT-18K06614
[Presentation] 小角X線散乱法による葉酸ナノ製剤の再分散性と構造評価2018
- Author(s)
  仙波久実、有馬寛、内山博雅、門田和紀、杉山和正、戸塚裕一
- Organizer
  日本薬剤学会第33年会
- Data Source
  KAKENHI-PROJECT-18K06614
[Presentation] A novel hybrid-nanocomposite formed by α-glucosyl stevia and water-soluble polymer: For dissolution enhancement of poorly soluble drugs2018
- Author(s)
  H. Uchiyama, K. Hayashi, K. Kadota, Y. Tozuka
- Organizer
  the 23rd International Congress of Chemical and Process Engineering (CHISA)
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K06614
[Presentation] 混合ミセル構造と難溶性薬物の溶解性改善効果の検討2018
- Author(s)
  佐藤公紀、藤森美季、Srivastava Anirudh、内山博雅、門田和紀、戸塚裕一
- Organizer
  第68回日本薬学会近畿支部大会
- Data Source
  KAKENHI-PROJECT-18K06614
[Presentation] 酵素処理イソクエルシトリンによる難溶解性フラボノイドの溶解性改善2018
- Author(s)
  内山博雅、田中舜、門田和紀、箕浦克彦、戸塚裕一
- Organizer
  日本食品化学学会第24回学術大会
- Data Source
  KAKENHI-PROJECT-18K06614
[Presentation] 機能性食品添加剤を粉砕媒体として利用した湿式ビーズミルによる葉酸ナノ粒子作製2016
- Author(s)
  門田和紀、仙波久実、戸塚裕一
- Organizer
  化学工学会第81年会
- Place of Presentation
  大阪
- Year and Date
  2016-03-13
- Data Source
  KAKENHI-PROJECT-25504018
[Presentation] 糖転移ナリンジンによる難水溶性薬物のカルボキシル基に起因した溶解性改善2016
- Author(s)
  岡本大樹、藤森美季、門田和紀、戸塚裕一
- Organizer
  日本薬学会136年会
- Place of Presentation
  横浜
- Year and Date
  2016-03-27
- Data Source
  KAKENHI-PROJECT-25504018
[Presentation] Curcumin の溶解度及び化学的安定性向上を指向した複合粒子の開発2015
- Author(s)
  大津誠行、大熊加奈子、佐藤秀行、門田和紀、戸塚裕一
- Organizer
  粉体工学会2015年度春期研究発表会
- Place of Presentation
  東京
- Year and Date
  2015-05-19
- Data Source
  KAKENHI-PROJECT-25504018
[Presentation] 糖転移ステビアのミセル形成能を利用した医薬品の溶解性改善2015
- Author(s)
  桑元俊輔、藤森美季、門田和紀、戸塚裕一
- Organizer
  粉体工学会2015年度秋期研究発表会
- Place of Presentation
  大阪
- Year and Date
  2015-10-13
- Data Source
  KAKENHI-PROJECT-25504018
[Presentation] 酵素処理ルチンによる光安定性改善を指向した葉酸ナノ粒子の作製2015
- Author(s)
  仙波久実、赤土了介、藤森美季、門田和紀、戸塚裕一
- Organizer
  第40回製剤・創剤セミナー
- Place of Presentation
  兵庫
- Year and Date
  2015-08-20
- Data Source
  KAKENHI-PROJECT-25504018
[Presentation] Highly-soluble and hydrolytic degradation-preventing formulation of curcumin using α-transglycosylated hesperidin and polyvinylpyrrolidone2015
- Author(s)
  Y. Tozuka, S. Otsu, M. Fujimori, H. Sato, K. Kadota
- Organizer
  Food structures, Digestion and Health, 3rd International Conference
- Place of Presentation
  Wellington, New Zealand
- Year and Date
  2015-10-28
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25504018
[Presentation] Folic acid nanoparticle production with highly dispersion and photostability using α-glycosyl rutin2015
- Author(s)
  K. Kadota, K. Semba, R. Shakudo, H. Sato, Y. Tozuka
- Organizer
  Food structures, Digestion and Health, 3rd International Conference
- Place of Presentation
  Wellington, New Zealand
- Year and Date
  2015-10-28
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25504018
[Presentation] 高圧湿式微粒化装置による酵素処理ルチンを粉砕媒体としたイトラコナゾールの溶解性改善2015
- Author(s)
  藤江美加、赤土了介、森岡俊光、橋爪宏太、門田和紀、戸塚裕一
- Organizer
  第40回製剤・創剤セミナー
- Place of Presentation
  兵庫
- Year and Date
  2015-08-20
- Data Source
  KAKENHI-PROJECT-25504018
[Presentation] α-Glycosyl Stevia と界面活性剤の複合体形成による pH 非依存性製剤の設計2015
- Author(s)
  桑元俊輔、藤森美季、佐藤秀行、門田和紀、戸塚裕一
- Organizer
  日本薬剤学会第30年会
- Place of Presentation
  長崎
- Year and Date
  2015-05-21
- Data Source
  KAKENHI-PROJECT-25504018
[Presentation] Nanocomposite formation of drug/trans-glycosylated additive for creating functional powders2015
- Author(s)
  Y. Tozuka
- Organizer
  The 5th International Conference on the Characterization and Control of Interfaces for High Quality Advanced Materials and the 51st Summer Symposium on Powder Technology
- Place of Presentation
  Okayama
- Year and Date
  2015-07-07
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25504018
[Presentation] Stabilizing effect of cyclodextrins on the water-soluble nanocomposite formulation of curcumin and transglycosylated aditives2015
- Author(s)
  Y. Tozuka, S. Otsu, K. Okuma, H. Sato, K. Kadota
- Organizer
  Joint conference of 8th Asian Cyclodextrin Conference and 32nd Cyclodextrin Symposium
- Place of Presentation
  Kumamoto
- Year and Date
  2015-05-14
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25504018
[Presentation] 小角X線散乱及びNMR測定によるα-Glucosyl hesperidin会合構造の評価2014
- Author(s)
  竹内喜大、東顕二郎、森田剛、門田和紀、戸塚裕一、山本恵司、森部久仁一
- Organizer
  第58回日本薬学会関東支部大会
- Place of Presentation
  東京
- Year and Date
  2014-10-04
- Data Source
  KAKENHI-PROJECT-25504018
[Presentation] 糖転移化合物が難水溶性薬物Ipriflavoneの溶解性に与える影響2014
- Author(s)
  中代　里美、相澤　恭、門田　和紀、戸塚　裕一
- Organizer
  日本薬学会134年会
- Place of Presentation
  熊本
- Data Source
  KAKENHI-PROJECT-25504018
[Presentation] Quercetinの抗酸化作用向上のための固体分散体の調製2014
- Author(s)
  藤森　美季、中代　里美、相澤　恭、門田　和紀、戸塚　裕一
- Organizer
  日本薬学会134年会
- Place of Presentation
  熊本
- Data Source
  KAKENHI-PROJECT-25504018
[Presentation] Dissolution and absorption enhancement of flurbiprofen induced by non-surface-active nanostructure of transglycosylated rutin2013
- Author(s)
  Y. Tozuka, K. Higashi, K. Moribe, H. Takeuchi, K. Yamamoto
- Organizer
  5th Asian Arden Conference
- Place of Presentation
  Nagoya, Japan
- Data Source
  KAKENHI-PROJECT-25504018
[Presentation] 界面張力変化を伴わないナノコンポジット形成による難水溶性化合物の可溶化と吸収性改善2013
- Author(s)
  戸塚　裕一、東　顕二郎、森部　久仁一、竹内　洋文、山本　恵司
- Organizer
  日本薬剤学会第28年会
- Place of Presentation
  名古屋
- Data Source
  KAKENHI-PROJECT-25504018
[Presentation] A strategic use of functional excipients to enhance the apparent solubility of API: a discovery of novel organic nanocomposite2012
- Author(s)
  Yuichi Tozuka
- Organizer
  ExAct Fair 2012
- Place of Presentation
  Singapore
- Invited
- Data Source
  KAKENHI-PROJECT-22790041
[Presentation] NMR 測定による Stevia-G の自己集合構造及び薬物溶解性改善メカニズムの解明2012
- Author(s)
  東顕二郎、Junying Zhang、戸塚裕一、 Limwikrant Waree、森部久仁一、竹内洋文、山本恵司
- Organizer
  日本薬剤学会第27 年会
- Data Source
  KAKENHI-PROJECT-22790041
[Presentation] Molecular Interaction-Mediated Particle Design for Improvement of Dissolution/Absorption Profile of Active Pharmaceutical Ingredient2012
- Author(s)
  Yuichi Tozuka
- Organizer
  The 2nd Advanced Study for Integrated Particle Science and Technology(ASIPST) Internatinal Symposium
- Place of Presentation
  京都
- Invited
- Data Source
  KAKENHI-PROJECT-22790041
[Presentation] 糖転移させた食品添加剤のナノ集合体形成を利用した製剤設計2012
- Author(s)
  戸塚裕一
- Organizer
  創剤フォーラム第18回シンポジウム
- Data Source
  KAKENHI-PROJECT-22790041
[Presentation] Eyedrop administration of edaravone-loaded liposomes protected against light-induces retinal damage2011
- Author(s)
  K.Hironaka, H.Shimazaki, T.Fujisawa, Y.Tozuka, K.Tsuruma, M.Shimazawa, H.Hara, H.Takeuchi
- Organizer
  38th Annual Meeting and Exposition of the Controlled Release Society
- Place of Presentation
  National Harbor, Maryland U.S.A.
- Data Source
  KAKENHI-PROJECT-21390011
[Presentation] 点眼したエダラボン封入リポソームの網膜障害に対する保護効果2011
- Author(s)
  廣中耕平, 嶌嵜博樹, 藤澤卓也, 戸塚裕一, 鶴間一寛, 嶋澤雅光, 原英彰, 竹内洋文
- Organizer
  第27回日本DDS学会
- Place of Presentation
  東京大学本郷キャンパス(東京都文京区本郷7-3-1)
- Year and Date
  2011-06-09
- Data Source
  KAKENHI-PROJECT-21390011
[Presentation] 点眼による網膜への薬物送達を目指した表面修飾リポソームの設計とその有用性評価2011
- Author(s)
  佐々木仁志、廣中耕平、田原耕平、戸塚裕一、竹内洋文
- Organizer
  第49回粉体に関する討論会
- Place of Presentation
  岩手県盛岡市いわて県民情報交流センター「アイーナ」8階会議室803
- Year and Date
  2011-11-14
- Data Source
  KAKENHI-PROJECT-21390011
[Presentation] リポソーム点眼製剤の表面特性とその眼内挙動に関する研究2011
- Author(s)
  佐々木仁志、廣中耕平、唐澤圭一、田原耕平、戸塚裕一、竹内洋文
- Organizer
  第28回製剤と粒子設計シンポジウム
- Place of Presentation
  ホテルニューオータニ大阪・大阪市
- Year and Date
  2011-10-28
- Data Source
  KAKENHI-PROJECT-21390011
[Presentation] NMR 測定を用いた水溶液中でのα-glycosyl hesperidin の構造評価2011
- Author(s)
  張峻頴、内山博雅、東顕二郎、戸塚裕一、森部久仁一、竹内洋文、山本恵司
- Organizer
  日本薬学会 131 年会
- Data Source
  KAKENHI-PROJECT-22790041
[Presentation] 眼科治療を目的とした表面修飾リポソームの設計2011
- Author(s)
  塚本敏雅、廣中耕平、藤澤卓也、佐々木、仁志、田原耕平、戸塚裕一、竹内洋文
- Organizer
  第21回日本病院薬剤師会東海ブロック学術大会・平成23年度日本薬学東海支部例会
- Place of Presentation
  名古屋・ウインクあいち
- Year and Date
  2011-11-23
- Data Source
  KAKENHI-PROJECT-21390011
[Presentation] 点眼したエダラボン封入リポソームの網膜障害に対する保護効果2011
- Author(s)
  廣中耕平, 嶌嵜博樹, 藤澤卓也, 戸塚裕一, 鶴間一寛, 嶋澤雅光, 原英彰, 竹内洋文
- Organizer
  第27回日本DDS学会
- Place of Presentation
  東京大学本郷キャンパス
- Year and Date
  2011-06-09
- Data Source
  KAKENHI-PROJECT-21390011
[Presentation] Dramatic Improvement of Dissolution and Absorption Properties of API by Spray-dried Powders with Transglycosylayed Materilas2011
- Author(s)
  Yuichi Tozuka
- Organizer
  Particulate Processes in the Pharmaceutical Industry III
- Place of Presentation
  Australia
- Year and Date
  2011-07-29
- Data Source
  KAKENHI-PROJECT-22790041
[Presentation] 糖転移ヘスペリジンとのナノ複合体形成による難水溶性化合物の溶解性および吸収性改善2011
- Author(s)
  戸塚裕一
- Organizer
  第3回糖転移ヘスペリジン・ビタミン P 研究会
- Data Source
  KAKENHI-PROJECT-22790041
[Presentation] 糖転移ステビアと界面活性剤のナノコンポジットの製剤学的利用2011
- Author(s)
  内山博雅、鋳物将明、西川真紘、戸塚裕一、竹内洋文
- Organizer
  日本薬剤学会第26 年会
- Data Source
  KAKENHI-PROJECT-22790041
[Presentation] Fluorescence investigation of lipid emulsion for retinal delivery via eyedrops2011
- Author(s)
  英林, 田原耕平, 戸塚裕一, 唐星, 竹内洋文
- Organizer
  第21回日本病院薬剤師会東海ブロック学術大会・平成23年度日本薬学東海支部例会
- Place of Presentation
  名古屋・ウインクあいち
- Year and Date
  2011-11-23
- Data Source
  KAKENHI-PROJECT-21390011
[Presentation] Design of a liposomal ocular delivery system targeting the posterior segments of the eye2011
- Author(s)
  K.Hironaka, Y.Tozuka, K.Tahara, H.K.Tsuruma, M.Shimazawa, Hara. H., Takeuchi. H.
- Organizer
  Asian Federation for Pharmaceutical Science Conference 2011
- Place of Presentation
  Kuala Lumpur, Malaysia
- Data Source
  KAKENHI-PROJECT-21390011
[Presentation] Design of a liposomal ocular delivery system targeting the posterior segments of the eye Asian2011
- Author(s)
  K. Hironaka, Y. Tozuka, K. Tahara, H. K. Tsuruma, M. Shimazawa, Hara. H. Takeuchi
- Organizer
  Federation for Pharmaceutical Science Conference
- Place of Presentation
  Malaysia
- Data Source
  KAKENHI-PROJECT-21390011
[Presentation] 糖転移化合物を用いた難水溶性薬物の溶解性及び吸収性改善に関する製剤設計2010
- Author(s)
  内山博雅、戸塚裕一、鋳物将明、竹内洋文
- Organizer
  日本薬剤学会第25 年会講演要旨集
- Data Source
  KAKENHI-PROJECT-22790041
[Presentation] 糖転移ヘスぺリジン及びステビアを用いた難水溶性薬物の溶解性及び吸収性改善2010
- Author(s)
  内山博雅、鋳物将明、戸塚裕一、竹内洋文
- Organizer
  2010 年度秋期研究発表会
- Data Source
  KAKENHI-PROJECT-22790041
[Presentation] 分子間相互作用を利用した新規粒子設計2010
- Author(s)
  戸塚裕一
- Organizer
  日本薬剤学会第25年会
- Place of Presentation
  徳島市
- Year and Date
  2010-05-12
- Data Source
  KAKENHI-PROJECT-22790041
[Presentation] 分子間相互作用を利用した新規粒子設計.日本薬剤学会奨励賞受賞講演2010
- Author(s)
  戸塚裕一
- Organizer
  日本薬剤学会第25 年会講演要旨集
- Data Source
  KAKENHI-PROJECT-22790041
[Presentation] NMR 測定によるα-Gヘスペリジンの薬物可溶化メカニズムの解明2010
- Author(s)
  東顕二郎、張峻頴、内山博雅、戸塚裕一、森部久仁一、竹内洋文、山本恵司
- Organizer
  第27回製剤と粒子設計シンポジウム
- Data Source
  KAKENHI-PROJECT-22790041
[Presentation] 糖転移化合物を用いた難水溶性成分の溶解性及び吸収性改善手法に関する研究2010
- Author(s)
  鋳物将明、内山博雅、戸塚裕一、竹内洋文
- Organizer
  平成 22 年度粉体工学会中部談話会
- Data Source
  KAKENHI-PROJECT-22790041
[Presentation] 糖転移化合物を用いた難水溶性化合物の溶解性/吸収性改善に関する研究2010
- Author(s)
  内山博雅、浅本房俊、鋳物将明、戸塚裕一、竹内洋文
- Organizer
  第45回技術討論会テキスト
- Data Source
  KAKENHI-PROJECT-22790041
[Presentation] 蛍光物質を用いた糖転移ステビアが示す溶解性改善メカニズムの解明2010
- Author(s)
  内山博雅、鋳物将明、浅本房俊、戸塚裕一、竹内洋文
- Organizer
  粉体工学会 2010 年度秋期研究発表会
- Data Source
  KAKENHI-PROJECT-22790041
[Presentation] Nanoparticle preparation of indomethacin using high pressure carbon dioxide2007
- Author(s)
  Yuichi Tozuka
- Organizer
  The British Pharmaceutical Conference & Exhibiti on 2007
- Place of Presentation
  英国(マンチェスター)
- Year and Date
  2007-09-12
- Data Source
  KAKENHI-PROJECT-17790029
[Presentation] 高圧二酸化炭素を用いた医薬品ナノ微粒子の新規調製法の開発2007
- Author(s)
  戸塚裕一
- Organizer
  粉体工学会第42回技術討論会
- Place of Presentation
  東京
- Year and Date
  2007-06-01
- Data Source
  KAKENHI-PROJECT-17790029
[Presentation] Nanoparticle Preparation of active pharmaceutical ingredients (APIs) by emulsion solvent diffusion method with cvclodextrin solutions2007
- Author(s)
  Yuichi Tozuka
- Organizer
  The third asian powder technology symposium 2007
- Place of Presentation
  中国(北京)
- Year and Date
  2007-09-04
- Data Source
  KAKENHI-PROJECT-17790029
[Presentation] 糖転移ルチン(Rutin-G)による難溶性薬物Tranilastの高吸収性製剤の開発
- Author(s)
  佐藤秀行、藤森美季、鈴木寛貴、門田和紀、尾上誠良、戸塚裕一
- Organizer
  第31回製剤と粒子設計シンポジウム
- Place of Presentation
  福岡
- Year and Date
  2014-10-23 – 2014-10-24
- Data Source
  KAKENHI-PROJECT-25504018
[Presentation] 機能性食品添加剤の分子間相互作用を利用した機能性複合粒子の調製
- Author(s)
  門田和紀、藤森美季、戸塚裕一
- Organizer
  粉体工学会2014年度春期研究発表会
- Place of Presentation
  京都
- Year and Date
  2014-05-29 – 2014-05-30
- Data Source
  KAKENHI-PROJECT-25504018
[Presentation] Solubility enhancement of hydrophobic flavones by forming a nano-structured complex with transglycosylated food additives
- Author(s)
  Y. Tozuka, M. Fujimori, S. Nakashiro, H. Sato, K. Kadota
- Organizer
  28th the European Federation of Food Science and Technology
- Place of Presentation
  Uppsala, Sweden
- Year and Date
  2014-11-25 – 2014-11-28
- Data Source
  KAKENHI-PROJECT-25504018
[Presentation] Enhanced dissolution of quercetin by forming composite particles via spray-drying
- Author(s)
  Y. Tozuka, M. Fujimori, K. Shimono, Y. Shirakawa, K. Kadota
- Organizer
  19th International Symposium on Industrial Crystallization
- Place of Presentation
  Toulouse, France
- Year and Date
  2014-09-16 – 2014-09-19
- Data Source
  KAKENHI-PROJECT-25504018

1. 門田和紀 (50709516)

# of Collaborated Projects: 3 results

# of Collaborated Products: 19 results
2. TAKEUCHI Hirofumi (50171616)

# of Collaborated Projects: 1 results

# of Collaborated Products: 16 results
3. OGUCHI Toshio (30169255)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
4. YAMAMOTO Keiji (50110341)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
5. Hiromasa Uchiyama (60792744)

# of Collaborated Projects: 1 results

# of Collaborated Products: 7 results
6. 原英彰 (20381717)

# of Collaborated Projects: 1 results

# of Collaborated Products: 12 results
7. 田原耕平 (30454325)

# of Collaborated Projects: 1 results

# of Collaborated Products: 7 results
8. Kamarainen Tero (20909890)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
9. WERLE Martin

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
10. SRIAMORNSAK Pornsak

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. HIGASHI Kenjirou

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
12. 森部久仁一

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Tozuka Yuichi 戸塚 裕一

戸塚 裕一 トヅカ ユウイチ

TOZUKA Yuichi 戸塚 裕一

Research Projects

Research Products

Co-Researchers

Building foundation of developing in silico technology-driven dry powder inhaler formulation applicable to drug modality

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A redesigned pulmonary formulation platform: Preparation of carrier particles with advanced alveolar transportabilityPrincipal Investigator

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Construction of drug development strategies for middle-molecule drug with low solubility and absorption based on coamorphous formation

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Hybrid formulations of the organic nanocomposite via structural investigationsPrincipal Investigator

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The use of functional nanocomposite structure for the development of novel functional food for specified health usesPrincipal Investigator

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Nano-composite formation for various pharmaceutical formulations.Principal Investigator

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Novel Dosage form design for ocular and pulmonary drug delivery based on analysis of behavior of nano-particle as drug carrier

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データマイニング法のナノ製剤開発への応用検討Principal Investigator

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Characterization for Pharmaceutical Solid Dispersion Prepared by means of Supercritical Carbon Dioxide

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[Book] 医薬品におけるDDS技術と製剤開発への応用2021

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[Book] くすりに学ぶナノ粒子・ナノカプセルの作り方.「究極のかたちをつくる」2009

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[Journal Article] Tuning the Phytoglycogen Size and Aggregate Structure with Solvent Quality: Influence of Water?Ethanol Mixtures Revealed by X-ray and Light Scattering Techniques2023

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[Journal Article] Improvement in Inhalation Properties of Theophylline and Levofloxacin by Co-Amorphization and Enhancement in Its Stability by Addition of Amino Acid as a Third Component2023

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[Journal Article] Effect of Solubility Improvement <i>via</i> Formation of an Amorphous Composite of Indomethacin and Sulindac on Membrane Permeability2023

Tozuka Yuichi 戸塚裕一

戸塚裕一トヅカユウイチ

TOZUKA Yuichi 戸塚裕一