nohara atsushi 野原淳

… Alternative Names

NOHARA Atsushi 野原淳

野原淳ノハラアツシ

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Researcher Number	50313648
Other IDs
External Links
Affiliation (Current)	2025: 金沢大学, 保健学系, 研究協力員
Affiliation (based on the past Project Information) *help	2024: 金沢大学, 保健学系, 研究協力員 2019 – 2022: 金沢大学, 保健学系, 研究協力員 2017 – 2018: 金沢大学, 保健管理センター, 助教 2016: 金沢大学, 医学系, 助教 2013 – 2015: 金沢大学, 医薬保健学総合研究科, 特任准教授 … More 2012: 金沢大学, 医薬保健学総合研究科, 准教授 2011: 金沢大学, 医学(系)研究科(研究院), 准教授 2007 – 2010: Kanazawa University, 医学系研究科, 特任助教 2008: Kanazawa University, 医学系研究科, 助教 2005 – 2006: 金沢大学, 医学系研究科, 助手 2002: 金沢大, 医学部附属病院, 助手 2001: 金沢大学, 医学部・附属病院, 助手 Less
Review Section/Research Field	Principal Investigator Metabolomics / Basic Section 54040:Metabolism and endocrinology-related / Metabolomics Except Principal Investigator Cardiovascular medicine / Laboratory medicine
Keywords	Principal Investigator 動脈硬化症 / ANGPTL8 / 家族性高コレステロール血症 / 糖尿病 / 冠動脈硬化症 / リポ蛋白リパーゼ / 核内受容体 / 小胞体ストレス / レムナント代謝 / XBP1 … More / 代謝異常関連脂肪肝 / 低比重リポ蛋白 / ライソゾーム酸性リパーゼ / 糖代謝 / コレステロールエステル化率 / HMG-CoA-reductase阻害薬 / 冠動脈疾患 / Lysosomal acid lipase / HDL-cholesterol / Coronary artery disease / Diabetes mellitus / Lipoprotein lipase / 糖代謝異常 / 脂質異常症 / LPL / 脂質代謝異常 / 胆汁酸受容体 / コレステロールエステル転送蛋白 / 残余リスク / コレステリルエステル転送蛋白 / リポ蛋白代謝 / 高比重リポ蛋白 / 動脈硬化学 / Retinoid-X-receptor / 遺伝子 / ゲノム / 脂質 / 内科 / コレステロール代謝 / 脂肪肝 / 遺伝子変異 / メタボリックシンドローム / 肥満 / 遺伝子多型 / 家族性複合型高脂血症 / 遺伝子解析 / 高脂血症 … More Except Principal Investigator 全エクソームシーケンス / 動脈硬化 / 高比重リポ蛋白 / 低HDL / メタボリックシンドローム / sdLDL / リポ蛋白リパーゼ / インスリン抵抗性 / 内臓脂肪 / 肝性リパーゼ / ANGPTL3 / HTGL / LPL Less

代謝異常関連脂肪肝におけるANGPTL8および小胞体ストレスの役割と先制医療の可能性Principal Investigator
- Principal Investigator
  
  野原淳
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 54040:Metabolism and endocrinology-related
- Research Institution
  Kanazawa University
Roles of Lysosomal Acid Lipase in Development of Coronary Artery DiseasePrincipal Investigator
- Principal Investigator
  
  Nohara Atsushi
- Project Period (FY)
  2017 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Metabolomics
- Research Institution
  Kanazawa University
Discovery and mechanistic analysis of a novel molecule associated with high-density lipoprotein metabolism using whole exome sequencing
- Principal Investigator
  
  Kawashiri Masaaki
- Project Period (FY)
  2015 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Cardiovascular medicine
- Research Institution
  Kanazawa University
ANGPTL8 function and development of coronary artery diseasePrincipal Investigator
- Principal Investigator
  
  Nohara Atsushi
- Project Period (FY)
  2014 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Metabolomics
- Research Institution
  Kanazawa University
High-density lipoprotein composition and development of coronary artery diseasePrincipal Investigator
- Principal Investigator
  
  NOHARA Atsushi
- Project Period (FY)
  2011 – 2013
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Metabolomics
- Research Institution
  Kanazawa University
Novel method of measuring activities of enzymes involved in lipid metabolism
- Principal Investigator
  
  KOBAYASHI Junji
- Project Period (FY)
  2008 – 2010
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Laboratory medicine
- Research Institution
  Kanazawa University
Regulation of Cardiovascular Risk Factors by Metabolism-associated Nuclear ReceptorsPrincipal Investigator
- Principal Investigator
  
  NOHARA Atsushi
- Project Period (FY)
  2007 – 2008
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Metabolomics
- Research Institution
  Kanazawa University
代謝関連核内受容体遺伝子変異機能解析と肥満および脂質代謝異常Principal Investigator
- Principal Investigator
  
  野原淳
- Project Period (FY)
  2005 – 2006
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Metabolomics
- Research Institution
  Kanazawa University
核内受容体PPAR-α遺伝子変異体機能解析と脂質代謝異常Principal Investigator
- Principal Investigator
  
  野原淳
- Project Period (FY)
  2001 – 2002
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Metabolomics
- Research Institution
  Kanazawa University

[Journal Article] Impact of High-Density Lipoprotein Function, Rather Than High-Density Lipoprotein Cholesterol Level, on Cardiovascular Disease Among Patients With Familial Hypercholesterolemia2023
- Author(s)
  Tada Hayato、Okada Hirofumi、Nohara Atsushi、Toh Ryuji、Harada Amane、Murakami Katsuhiro、Iino Takuya、Nagao Manabu、Ishida Tatsuro、Hirata Ken-ichi、Takamura Masayuki、Kawashiri Masa-aki
- Journal Title
  
  Circ J
  
  Volume: 87 Issue: 6 Pages: 806-812
- DOI
  10.1253/circj.CJ-22-0560
- ISSN
  1346-9843, 1347-4820
- Year and Date
  2023-05-25
- Language
  English
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K09859
[Journal Article] Attainment of the low-density lipoprotein cholesterol treatment target and prognosis of heterozygous familial hypercholesterolemia2023
- Author(s)
  Tada Hayato、Nomura Akihiro、Nohara Atsushi、Usui Soichiro、Sakata Kenji、Hayashi Kenshi、Fujino Noboru、Takamura Masayuki、Kawashiri Masa-aki
- Journal Title
  
  Atherosclerosis
  
  Volume: 371 Pages: 61-66
- DOI
  10.1016/j.atherosclerosis.2023.03.005
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21K08075, KAKENHI-PROJECT-17K09859, KAKENHI-PROJECT-20H03927
[Journal Article] Impact of Healthy Lifestyle in Patients With Familial Hypercholesterolemia2023
- Author(s)
  Tada H, Kojima N, Yamagami K, Nomura A, Nohara A, Usui S, Sakata K, Hayashi K, Fujino N, Takamura M, Kawashiri MA
- Journal Title
  
  JACC Asia
  
  Volume: 3 Issue: 1 Pages: 152-160
- DOI
  10.1016/j.jacasi.2022.10.012
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22K10485, KAKENHI-PROJECT-20H03927, KAKENHI-PROJECT-21H03179, KAKENHI-PROJECT-17K09859
[Journal Article] Effects of Different Types of Pathogenic Variants on Phenotypes of Familial Hypercholesterolemia2022
- Author(s)
  Tada Hayato、Kojima Nobuko、Yamagami Kan、Nomura Akihiro、Nohara Atsushi、Usui Soichiro、Sakata Kenji、Fujino Noboru、Takamura Masayuki、Kawashiri Masa-Aki
- Journal Title
  
  Frontiers in Genetics
  
  Volume: 13 Pages: 872056-872056
- DOI
  10.3389/fgene.2022.872056
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20H03927, KAKENHI-PROJECT-17K09859, KAKENHI-PROJECT-20K17110
[Journal Article] Genetic mutations, regression of Achilles tendon thickness, and cardiovascular events among patients with familial hypercholesterolemia2022
- Author(s)
  Tada Hayato、Okada Hirofumi、Nohara Atsushi、Takamura Masayuki、Kawashiri Masa-aki
- Journal Title
  
  Atherosclerosis
  
  Volume: 340 Pages: 28-34
- DOI
  10.1016/j.atherosclerosis.2021.11.031
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K09859
[Journal Article] Impact of variants of uncertain significance of LDL receptor on phenotypes of familial hypercholesterolemia2022
- Author(s)
  Tada Hayato、Kojima Nobuko、Yamagami Kan、Nomura Akihiro、Nohara Atsushi、Usui Soichiro、Sakata Kenji、Hayashi Kenshi、Fujino Noboru、Takamura Masayuki、Kawashiri Masa-aki
- Journal Title
  
  Journal of Clinical Lipidology
  
  Volume: 16 Issue: 6 Pages: 863-869
- DOI
  10.1016/j.jacl.2022.09.007
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21K08075, KAKENHI-PROJECT-22K10485, KAKENHI-PROJECT-20H03927, KAKENHI-PROJECT-17K09859, KAKENHI-PROJECT-20K17110
[Journal Article] Whole Exome Sequencing Insufficient for a Definitive Diagnosis of a Patient with Compound Heterozygous Familial Hypercholesterolemia2022
- Author(s)
  Okada Hirofumi、Tada Hayato、Nomura Akihiro、Nohara Atsushi、Okeie Kazuyasu、Nozue Tsuyoshi、Michishita Ichiro、Takamura Masayuki、Takemura Hirofumi、Kawashiri Masa-aki
- Journal Title
  
  Intern. Med.
  
  Volume: 61 Issue: 19 Pages: 2883-2889
- DOI
  10.2169/internalmedicine.8989-21
- ISSN
  0918-2918, 1349-7235
- Year and Date
  2022-10-01
- Language
  English
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K09859, KAKENHI-PROJECT-20K17110
[Journal Article] Familial Hypercholesterolemia in Patients with Acute Coronary Syndrome: Genetic Insights from EXPLORE-J2022
- Author(s)
  Harada-Shiba Mariko、Ako Junya、Hirayama Atsushi、Nakamura Masato、Nohara Atsushi、Sato Kayoko、Murakami Yoshitaka、Koshida Ryusuke、Ozaki Asuka、Arai Hidenori
- Journal Title
  
  Journal of Atherosclerosis and Thrombosis
  
  Volume: 29 Issue: 8 Pages: 1201-1212
- DOI
  10.5551/jat.62989
- NAID
  130008088102
- ISSN
  1340-3478, 1880-3873
- Year and Date
  2022-08-01
- Language
  English
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K09859, KAKENHI-PROJECT-21K08117
[Journal Article] Early diagnosis and treatments in childhood are associated with better prognosis in patients with familial hypercholesterolemia2022
- Author(s)
  Tada Hayato、Kojima Nobuko、Yamagami Kan、Nomura Akihiro、Nohara Atsushi、Usui Soichiro、Sakata Kenji、Takamura Masayuki、Kawashiri Masa-aki
- Journal Title
  
  American Journal of Preventive Cardiology
  
  Volume: 12 Pages: 100434-100434
- DOI
  10.1016/j.ajpc.2022.100434
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K08486, KAKENHI-PROJECT-17K09859
[Journal Article] Prevalent Coronary Artery Disease and Undertreatment in Heterozygous Familial Hypercholesterolemia -Real-World Data and “Heterozygous FH Score” from FAME Study-2022
- Author(s)
  Nohara Atsushi
- Journal Title
  
  Journal of Atherosclerosis and Thrombosis
  
  Volume: 29 Issue: 5 Pages: 567-570
- DOI
  10.5551/jat.ED199
- ISSN
  1340-3478, 1880-3873
- Year and Date
  2022-05-01
- Language
  English
- Data Source
  KAKENHI-PROJECT-17K09859
[Journal Article] Achilles Tendon Thickness Assessed by X-ray Predicting a Pathogenic Mutation in Familial Hypercholesterolemia Gene2022
- Author(s)
  Tada Hayato、Hori Mika、Matsuki Kota、Ogura Masatsune、Nohara Atsushi、Kawashiri Masa-aki、Harada-Shiba Mariko
- Journal Title
  
  Journal of Atherosclerosis and Thrombosis
  
  Volume: 29 Issue: 6 Pages: 816-824
- DOI
  10.5551/jat.62869
- NAID
  130008060205
- ISSN
  1340-3478, 1880-3873
- Year and Date
  2022-06-01
- Language
  English
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K08143, KAKENHI-PROJECT-17K09859
[Journal Article] The Japanese Society for Apheresis clinical practice guideline for therapeutic apheresis2021
- Author(s)
  Abe T, Matsuo H, Furuichi K, Furukawa Y, Furuya M, Furuya T, Hanafusa N, Hara W, Harada-Shiba M, Hasegawa M, Hattori N, Hattori M, Hidaka S, Hidaka T, Nohara A, Nomura K, Yamaji K., et al
- Journal Title
  
  Therapeutic Apheresis and Dialysis
  
  Volume: 25 Issue: 6 Pages: 728-876
- DOI
  10.1111/1744-9987.13749
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K09859
[Journal Article] JCS 2018 Guideline on Diagnosis of Chronic Coronary Heart Diseases2021
- Author(s)
  Yamagishi Masakazu、Tamaki Nagara、Akasaka Takashi、Ikeda Takanori、Ueshima Kenji、Uemura Shiro、----------------、Kurata Akira、---、Yasuda Satoshi、Yoshino Hideaki、on behalf of the Japanese Circulation Society Working Group
- Journal Title
  
  Circ J
  
  Volume: 85 Issue: 4 Pages: 402-572
- DOI
  10.1253/circj.CJ-19-1131
- NAID
  130008003075
- ISSN
  1346-9843, 1347-4820
- Year and Date
  2021-03-25
- Language
  English
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K07998, KAKENHI-PROJECT-20K08052, KAKENHI-PROJECT-20K08455, KAKENHI-PROJECT-17K09859
[Journal Article] Prognostic impact of cascade screening for familial hypercholesterolemia on cardiovascular events2021
- Author(s)
  Tada H, Okada H, Nomura A, Nohara A, Yamagishi M, Takamura M, Kawashiri MA
- Journal Title
  
  J Clin Lipidol
  
  Volume: in press Issue: 2 Pages: 358-365
- DOI
  10.1016/j.jacl.2020.12.012
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K08064, KAKENHI-PROJECT-19K08553, KAKENHI-PROJECT-17K09859
[Journal Article] Lipid Management and 2-Year Clinical Outcomes in Japanese Patients with Acute Coronary Syndrome: EXPLORE-J2021
- Author(s)
  Nakamura Masato、Ako Junya、Arai Hidenori、Hirayama Atsushi、Nohara Atsushi、Murakami Yoshitaka、Ozaki Asuka、Harada-Shiba Mariko
- Journal Title
  
  Journal of Atherosclerosis and Thrombosis
  
  Volume: 28 Issue: 12 Pages: 1307-1322
- DOI
  10.5551/jat.59543
- NAID
  130008123361
- ISSN
  1340-3478, 1880-3873
- Year and Date
  2021-12-01
- Language
  English
- Data Source
  KAKENHI-PROJECT-17K09859
[Journal Article] Homozygous Familial Hypercholesterolemia2021
- Author(s)
  Atsushi Nohara, Hayato Tada, Masatsune Ogura, Sachiko Okazaki, Koh Ono, Hitoshi Shimano, Hiroyuki Daida, Kazushige Dobashi, Toshio Hayashi, Mika Hori, Kota Matsuki, Tetsuo Minamino, Shinji Yokoyama, Mariko Harada-Shiba.
- Journal Title
  
  Journal of Atherosclerosis and Thrombosis
  
  Volume: 28 Issue: 7 Pages: 665-678
- DOI
  10.5551/jat.RV17050
- NAID
  130008060156
- ISSN
  1340-3478, 1880-3873
- Year and Date
  2021-07-01
- Language
  English
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K08474, KAKENHI-PROJECT-17K09859, KAKENHI-PROJECT-21K08143
[Journal Article] Serum sitosterol level predicting ABCG5 or ABCG8 genetic mutations2020
- Author(s)
  Kojima Nobuko、Tada Hayato、Usui Soichiro、Sakata Kenji、Hayashi Kenshi、Nohara Atsushi、Inazu Akihiro、Takamura Masayuki、Kawashiri Masa-aki
- Journal Title
  
  Clinica Chimica Acta
  
  Volume: 507 Pages: 11-16
- DOI
  10.1016/j.cca.2020.04.003
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K09859, KAKENHI-PROJECT-19K08553, KAKENHI-PROJECT-20K11621, KAKENHI-PROJECT-18K08100
[Journal Article] Reducing the Clinical and Public Health Burden of Familial Hypercholesterolemia: A Global Call to Action.2020
- Author(s)
  Representatives of the Global Familial Hypercholesterolemia Community,
- Journal Title
  
  JAMA Cardiol.
  
  Volume: - Issue: 2 Pages: 217-217
- DOI
  10.1001/jamacardio.2019.5173
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18H03532, KAKENHI-PROJECT-17K09859
[Journal Article] A Catalog of the Pathogenic Mutations of LDL Receptor Gene in Japanese Familial Hypercholesterolemia2020
- Author(s)
  Tada H*, Hori M*(*equal contribution), Nomura A, Hosomichi K, Nohara A, Kawashiri M*, Harada-Shiba M*
- Journal Title
  
  Journal of Clinical Lipidology
  
  Volume: - Issue: 3 Pages: 346-351
- DOI
  10.1016/j.jacl.2020.03.002
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K08681, KAKENHI-PROJECT-17K09859, KAKENHI-PROJECT-19K08553, KAKENHI-PROJECT-20K21705, KAKENHI-PUBLICLY-19H05344
[Journal Article] A Healthy Family of Familial Hypobetalipoproteinemia Caused by a Protein-truncating Variant in the PCSK9 Gene2020
- Author(s)
  Tada H, Okada H, Nomura A, Nohara A, Takamura M, Kawashiri MA
- Journal Title
  
  Intern. Med.
  
  Volume: 59 Issue: 6 Pages: 783-787
- DOI
  10.2169/internalmedicine.3737-19
- NAID
  130007808808
- ISSN
  0918-2918, 1349-7235
- Year and Date
  2020-03-15
- Language
  English
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K08064, KAKENHI-PROJECT-17K09859
[Journal Article] A reassessment of the Japanese clinical diagnostic criteria of familial hypercholesterolemia in a hospital-based cohort using comprehensive genetic analysis2020
- Author(s)
  Tada Hayato、Okada Hirofumi、Nomura Akihiro、Nohara Atsushi、Usui Soichiro、Sakata Kenji、Takamura Masayuki、Kawashiri Masa-aki
- Journal Title
  
  Practical Laboratory Medicine
  
  Volume: 22 Pages: e00180-e00180
- DOI
  10.1016/j.plabm.2020.e00180
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K09859, KAKENHI-PROJECT-19K08553
[Journal Article] Clinical whole exome sequencing in severe hypertriglyceridemia2019
- Author(s)
  Tada Hayato、Nomura Akihiro、Okada Hirofumi、Nakahashi Takuya、Nozue Tsuyoshi、Hayashi Kenshi、Nohara Atsushi、Yagi Kunimasa、Inazu Akihiro、Michishita Ichiro、Mabuchi Hiroshi、Yamagishi Masakazu、Kawashiri Masa-aki
- Journal Title
  
  Clinica Chimica Acta
  
  Volume: 488 Pages: 31-39
- DOI
  10.1016/j.cca.2018.10.041
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K09859, KAKENHI-PROJECT-15K09118, KAKENHI-PROJECT-18K08505, KAKENHI-PROJECT-18K10204
[Journal Article] Investigation into Lipid Management in Acute Coronary Syndrome Patients from the EXPLORE-J Study2019
- Author(s)
  Nakamura Masato、Ako Junya、Arai Hidenori、Hirayama Atsushi、Murakami Yoshitaka、Nohara Atsushi、Uno Kiyoko、Ozaki Asuka、Harada-Shiba Mariko
- Journal Title
  
  Journal of Atherosclerosis and Thrombosis
  
  Volume: 26 Issue: 6 Pages: 559-572
- DOI
  10.5551/jat.45583
- NAID
  130007657512
- ISSN
  1340-3478, 1880-3873
- Year and Date
  2019-06-01
- Language
  English
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K09859
[Journal Article] Safety and Efficacy of Lomitapide in Japanese Patients with Homozygous Familial Hypercholesterolemia (HoFH): Results from the AEGR-733-301 Long-Term Extension Study2019
- Author(s)
  Nohara Atsushi、Otsubo Yoshihiko、Yanagi Koji、Yoshida Masayuki、Ikewaki Katsunori、Harada-Shiba Mariko、Jurecka Agnieszka
- Journal Title
  
  Journal of Atherosclerosis and Thrombosis
  
  Volume: 26 Issue: 4 Pages: 368-377
- DOI
  10.5551/jat.45708
- NAID
  130007621868
- ISSN
  1340-3478, 1880-3873
- Year and Date
  2019-04-01
- Language
  English
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K09859
[Journal Article] Rare Protein-Truncating Variants in APOB, Lower Low-Density Lipoprotein Cholesterol, and Protection Against Coronary Heart Disease2019
- Author(s)
  Peloso Gina M.、Nomura Akihiro、Khera Amit V.、Nohara Atsushi、Kawashiri Masa-aki、Tada Hayato、Dewey Frederick E.、Carey David J.、Baras Aris、Kathiresan Sekar et al.
- Journal Title
  
  Circulation: Genomic and Precision Medicine
  
  Volume: 12 Issue: 5
- DOI
  10.1161/circgen.118.002376
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K09859, KAKENHI-PROJECT-19K08553
[Journal Article] Rare and Deleterious Mutations in ABCG5/ABCG8 Genes Contribute to Mimicking and Worsening of Familial Hypercholesterolemia Phenotype2019
- Author(s)
  Tada Hayato、Okada Hirofumi、Nomura Akihiro、Yashiro Satoshi、Nohara Atsushi、Ishigaki Yasushi、Takamura Masayuki、Kawashiri Masa-aki
- Journal Title
  
  Circ J
  
  Volume: 83 Issue: 9 Pages: 1917-1924
- DOI
  10.1253/circj.CJ-19-0317
- NAID
  130007695018
- ISSN
  1346-9843, 1347-4820
- Year and Date
  2019-08-23
- Language
  English
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K09859, KAKENHI-PROJECT-18K07484, KAKENHI-PROJECT-18K08064, KAKENHI-PROJECT-18K08523, KAKENHI-PROJECT-19K08553
[Journal Article] Sitosterolemia, Hypercholesterolemia, and Coronary Artery Disease2018
- Author(s)
  Tada Hayato、Nohara Atsushi、Inazu Akihiro、Sakuma Nagahiko、Mabuchi Hiroshi、Kawashiri Masa-aki
- Journal Title
  
  Journal of Atherosclerosis and Thrombosis
  
  Volume: 25 Issue: 9 Pages: 783-789
- DOI
  10.5551/jat.RV17024
- NAID
  130007479708
- ISSN
  1340-3478, 1880-3873
- Year and Date
  2018-09-01
- Language
  English
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K09859, KAKENHI-PROJECT-15K09118
[Journal Article] Molecular and functional characterization of familial chylomicronemia syndrome.2018
- Author(s)
  Teramoto R, Tada H, Kawashiri MA, Nohara A, Nakahashi T, Konno T, Inazu A, Mabuchi H, Yamagishi M, Hayashi K.
- Journal Title
  
  Atherosclerosis.
  
  Volume: 269 Pages: 272-278
- DOI
  10.1016/j.atherosclerosis.2017.11.006
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15K09118
[Journal Article] Guidance for Pediatric Familial Hypercholesterolemia 20172018
- Author(s)
  Harada-Shiba Mariko、Ohta Takao、Ohtake Akira、Ogura Masatsune、Dobashi Kazushige、Nohara Atsushi、Yamashita Shizuya、Yokote Koutaro、Joint Working Group by Japan Pediatric Society and Japan Atherosclerosis Society for Making Guidance of Pediatric Familial Hypercholesterolemia
- Journal Title
  
  Journal of Atherosclerosis and Thrombosis
  
  Volume: 25 Issue: 6 Pages: 539-553
- DOI
  10.5551/jat.CR002
- NAID
  130007382567
- ISSN
  1340-3478, 1880-3873
- Year and Date
  2018-06-01
- Language
  English
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K09859, KAKENHI-PROJECT-18K08125, KAKENHI-PROJECT-17H02100
[Journal Article] Assessment of arterial stiffness in patients with familial hypercholesterolemia.2018
- Author(s)
  Tada H, Kawashiri MA, Nohara A, Inazu A, Mabuchi H, Yamagishi M.
- Journal Title
  
  J Clin Lipidol.
  
  Volume: 12 Issue: 2 Pages: 397-402
- DOI
  10.1016/j.jacl.2017.12.002
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15K09118, KAKENHI-PROJECT-16K19394
[Journal Article] Impact of B-Type Natriuretic Peptide Level on Risk Stratification of Thromboembolism and Death in Patients With Nonvalvular Atrial Fibrillation　― The Hokuriku-Plus AF Registry ―2018
- Author(s)
  Hayashi Kenshi、Tsuda Toyonobu、Nomura Akihiro、Fujino Noboru、Nohara Atsushi、Sakata Kenji、Konno Tetsuo、Nakanishi Chiaki、Tada Hayato、Nagata Yoji、Teramoto Ryota、Tanaka Yoshihiro、Kawashiri Masa-aki、Yamagishi Masakazu、on behalf of the Hokuriku-Plus AF Registry Investigators
- Journal Title
  
  Circ J
  
  Volume: 82 Issue: 5 Pages: 1271-1278
- DOI
  10.1253/circj.CJ-17-1085
- NAID
  130006725972
- ISSN
  1346-9843, 1347-4820
- Language
  English
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15KK0302, KAKENHI-PROJECT-17K09859, KAKENHI-PROJECT-15K09118
[Journal Article] Aortic Root Calcification Score as an Independent Factor for Predicting Major Adverse Cardiac Events in Familial Hypercholesterolemia2018
- Author(s)
  Okada H, Tada H, Hayashi K, Kawashima H, Takata T, Sakata K, Nohara A, Mabuchi H, Yamagishi M, Kawashiri MA
- Journal Title
  
  Journal of Atherosclerosis and Thrombosis
  
  Volume: 25 Issue: 7 Pages: 634-642
- DOI
  10.5551/jat.42705
- NAID
  130007386952
- ISSN
  1340-3478, 1880-3873
- Year and Date
  2018-07-01
- Language
  English
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16K19394, KAKENHI-PROJECT-17K09859, KAKENHI-PROJECT-15K09118
[Journal Article] Impact of genetic testing on low-density lipoprotein cholesterol in patients with familial hypercholesterolemia (GenTLe-FH): a randomised waiting list controlled open-label study protocol.2018
- Author(s)
  Nomura A, Tada H, Okada H, Nohara A, Ishikawa H, Yoshimura K, Kawashiri MA.
- Journal Title
  
  BMJ Open.
  
  Volume: 8 Issue: 12 Pages: e023636-e023636
- DOI
  10.1136/bmjopen-2018-023636
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15K09118, KAKENHI-PROJECT-16K19394
[Journal Article] Oligogenic familial hypercholesterolemia, LDL cholesterol, and coronary artery disease2018
- Author(s)
  Tada Hayato、Kawashiri Masa-aki、Nomura Akihiro、Teramoto Ryota、Hosomichi Kazuyoshi、Nohara Atsushi、Inazu Akihiro、Mabuchi Hiroshi、Tajima Atsushi、Yamagishi Masakazu
- Journal Title
  
  Journal of Clinical Lipidology
  
  Volume: 12 Issue: 6 Pages: 1436-1444
- DOI
  10.1016/j.jacl.2018.08.006
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K09859, KAKENHI-PROJECT-18K08064, KAKENHI-PLANNED-16H06502, KAKENHI-PROJECT-15K09118, KAKENHI-PROJECT-17K19804
[Journal Article] Oral Fat Tolerance Test for Sitosterolemia and Familial Hypercholesterolemia: A Study Protocol2018
- Author(s)
  Nomura A, Tada H, Nohara A, Kawashiri MA, Yamagishi M.
- Journal Title
  
  Journal of Atherosclerosis and Thrombosis
  
  Volume: 25 Issue: 8 Pages: 741-746
- DOI
  10.5551/jat.42960
- NAID
  130007429926
- ISSN
  1340-3478, 1880-3873
- Year and Date
  2018-08-01
- Language
  English
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15K09118
[Journal Article] Post-prandial Remnant Lipoprotein Metabolism in Sitosterolemia2018
- Author(s)
  Tada Hayato、Nomura Akihiro、Nohara Atsushi、Inazu Akihiro、Mabuchi Hiroshi、Yamagishi Masakazu、Kawashiri Masa-aki
- Journal Title
  
  Journal of Atherosclerosis and Thrombosis
  
  Volume: 25 Issue: 12 Pages: 1188-1195
- DOI
  10.5551/jat.44768
- NAID
  130007539352
- ISSN
  1340-3478, 1880-3873
- Year and Date
  2018-12-01
- Language
  English
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K09859, KAKENHI-PROJECT-15K09118, KAKENHI-PROJECT-16K19394
[Journal Article] High frequency of type 2 diabetes and impaired glucose tolerance in Japanese subjects with the angiopoietin-like protein 8 R59W variant.2018
- Author(s)
  Liu J, Yagi K, Nohara A, Chujo D, Ohbatake A, Fujimoto A, Miyamoto Y, Kobayashi J, Yamagishi M.
- Journal Title
  
  J Clin Lipidol
  
  Volume: 12 Issue: 2 Pages: 331-337
- DOI
  10.1016/j.jacl.2017.12.011
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K09859, KAKENHI-PROJECT-15K08544, KAKENHI-PROJECT-15K08627, KAKENHI-PROJECT-18K07484, KAKENHI-PROJECT-18K08505, KAKENHI-PROJECT-18K10204, KAKENHI-PROJECT-19K21300
[Journal Article] Remnant-like particles and coronary artery disease in familial hypercholesterolemia2018
- Author(s)
  Tada H, Kawashiri MA, Nohara A, Sakata K, Inazu A, Mabuchi H, Yamagishi M, Hayashi K
- Journal Title
  
  Clin Chim Acta
  
  Volume: 印刷中 Pages: 120-123
- DOI
  10.1016/j.cca.2018.04.007
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16K19394, KAKENHI-PROJECT-17K09859, KAKENHI-PROJECT-15K09118
[Journal Article] Guidelines for Diagnosis and Treatment of Familial Hypercholesterolemia 20172018
- Author(s)
  Harada-Shiba Mariko、Arai Hidenori、Ishigaki Yasushi、Ishibashi Shun、Okamura Tomonori、Ogura Masatsune、Dobashi Kazushige、Nohara Atsushi、Bujo Hideaki、Miyauchi Katsumi、Yamashita Shizuya、Yokote Koutaro、Working Group by Japan Atherosclerosis Society for Making Guidance of Familial Hypercholesterolemia
- Journal Title
  
  Journal of Atherosclerosis and Thrombosis
  
  Volume: 25 Issue: 8 Pages: 751-770
- DOI
  10.5551/jat.CR003
- NAID
  130007429791
- ISSN
  1340-3478, 1880-3873
- Year and Date
  2018-08-01
- Language
  English
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K09859, KAKENHI-PROJECT-18K08125, KAKENHI-PROJECT-18K08523
[Journal Article] Statement for Appropriate Clinical Use of PCSK9 Inhibitors2018
- Author(s)
  Nohara Atsushi、Ohmura Hirotoshi、Okazaki Hiroaki、Ogura Masatsune、Kitagawa Kazuo、Koseki Masahiro、Sato Kayoko、Tsukamoto Kazuhisa、Yamashita Shizuya、On behalf of the Japan Atherosclerosis Society Working Group on Statement for Appropriate Use of PCSK9 Inhibitors
- Journal Title
  
  Journal of Atherosclerosis and Thrombosis
  
  Volume: 25 Issue: 8 Pages: 747-750
- DOI
  10.5551/jat.45229
- NAID
  130007429079
- ISSN
  1340-3478, 1880-3873
- Year and Date
  2018-08-01
- Language
  English
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K09859, KAKENHI-PROJECT-18K08125, KAKENHI-PROJECT-15K09129
[Journal Article] Impact of clinical signs and genetic diagnosis of familial hypercholesterolaemia on the prevalence of coronary artery disease in patients with severe hypercholesterolaemia.2017
- Author(s)
  Tada H, Kawashiri MA, Nohara A, Inazu A, Mabuchi H, Yamagishi M.
- Journal Title
  
  Eur Heart J.
  
  Volume: - Issue: 20 Pages: 1573-1579
- DOI
  10.1093/eurheartj/ehx004
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15K09118, KAKENHI-PROJECT-16K19394, KAKENHI-PROJECT-17K09859
[Journal Article] Assessments of Carotid Artery Plaque Burden in Patients With Familial Hypercholesterolemia.2017
- Author(s)
  Tada H, Kawashiri MA, Okada H, Nakahashi T, Sakata K, Nohara A, Inazu A, Mabuchi H, Yamagishi M, Hayashi K.
- Journal Title
  
  Am J Cardiol.
  
  Volume: 120 Issue: 11 Pages: 1955-1960
- DOI
  10.1016/j.amjcard.2017.08.012
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15K09118, KAKENHI-PROJECT-17K09859
[Journal Article] Lipid Management in a Japanese Community:Attainment Rate of Target Set by the Japan Atherosclerosis Society Guidelines for the Prevention of Atherosclerotic Cardiovascular Diseases 20122017
- Author(s)
  Tada H, Kawashiri MA, Nohara A, Inazu A, Kobayashi J, Yasuda K, Mabuchi H, Yamagishi M, Hayashi K.
- Journal Title
  
  Journal of Atherosclerosis and Thrombosis
  
  Volume: 24 Issue: 3 Pages: 338-345
- DOI
  10.5551/jat.36004
- NAID
  130005397947
- ISSN
  1340-3478, 1880-3873
- Language
  English
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-26461359, KAKENHI-PROJECT-15K08627, KAKENHI-PROJECT-15K09118
[Journal Article] Impact of evolocumab treatment on low-density lipoprotein cholesterol levels in heterozygous familial hypercholesterolemic patients withdrawing from regular apheresis.2017
- Author(s)
  Kawashiri MA, Nohara A, Higashikata T, Tada H, Nakanishi C, Okada H, Konno T, Sakata K, Hayashi K, Inazu A, Mabuchi H, Yamagishi M.
- Journal Title
  
  Atherosclerosis.
  
  Volume: 265 Pages: 225-230
- DOI
  10.1016/j.atherosclerosis.2017.09.011
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15K09118
[Journal Article] sLR11 as a novel predictor of vascular calcification.2017
- Author(s)
  Nohara A.
- Journal Title
  
  Atherosclerosis
  
  Volume: 265 Pages: 242-243
- DOI
  10.1016/j.atherosclerosis.2017.07.025
- Data Source
  KAKENHI-PROJECT-17K09859
[Journal Article] Minimal contribution of severe hypertriglyceridemia in L-asparaginase-associated pancreatitis developed in a child with acute lymphocytic leukemia2016
- Author(s)
  Goto Y, Nishimura R, Nohara A, Mase S, Fujiki T, Irabu H, Kuroda R, Araki R, Ikawa Y, Maeba H, Yachie A.
- Journal Title
  
  Rinsho Ketsueki
  
  Volume: 57 Issue: 8 Pages: 994-998
- DOI
  10.11406/rinketsu.57.994
- NAID
  130006882249
- ISSN
  0485-1439, 1882-0824
- Language
  Japanese
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-26461359
[Journal Article] A Rare Coincidence of Sitosterolemia and Familial Mediterranean Fever Identified by Whole Exome Sequencing2016
- Author(s)
  Tada H, Kawashiri MA, Okada H, Endo S, Toyoshima Y, Konno T, Nohara A, Inazu A, Takao A, Mabuchi H, Yamagishi M, Hayashi K.
- Journal Title
  
  Journal of Atherosclerosis and Thrombosis
  
  Volume: 23 Issue: 7 Pages: 884-890
- DOI
  10.5551/jat.34827
- NAID
  130005160390
- ISSN
  1340-3478, 1880-3873
- Language
  English
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15K09118
[Journal Article] A de novo mutation of the LDL receptor gene as the cause of familial hypercholesterolemia identified using whole exome sequencing.2016
- Author(s)
  Tada H, Hosomichi K, Okada H, Kawashiri MA, Nohara A, Inazu A, Tomizawa S, Tajima A, Mabuchi H, Hayashi K.
- Journal Title
  
  Clin Chim Acta.
  
  Volume: 453 Pages: 194-196
- DOI
  10.1016/j.cca.2015.12.028
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15K09118, KAKENHI-PROJECT-15H04320, KAKENHI-PROJECT-26893094
[Journal Article] Efficacy and Safety of Alirocumab in Japanese Patients With Heterozygous Familial Hypercholesterolemia or at High Cardiovascular Risk With Hypercholesterolemia Not Adequately Controlled With Statins　– ODYSSEY JAPAN Randomized Controlled Trial –2016
- Author(s)
  Teramoto T, Kobayashi M, Tasaki H, Yagyu H, Higashikata T, Takagi Y, Uno K, Baccara-Dinet MT, Nohara A.
- Journal Title
  
  Circ J
  
  Volume: 80 Issue: 9 Pages: 1980-1987
- DOI
  10.1253/circj.CJ-16-0387
- NAID
  130005406873
- ISSN
  1346-9843, 1347-4820
- Language
  English
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-26461359
[Journal Article] Changes in lipoprotein lipase and endothelial lipase mass in familial hypercholesterolemia during three-drug lipid-lowering combination therapy2016
- Author(s)
  Tada H, Kobayashi J, Kawashiri MA, Miyashita K, Nohara A, Inazu A, Nakajima K, Mabuchi H, Yamagishi M
- Journal Title
  
  Lipids Health Dis
  
  Volume: 15 Issue: 1 Pages: 66-66
- DOI
  10.1186/s12944-016-0238-z
- NAID
  120006325352
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15K08627, KAKENHI-PROJECT-26461359, KAKENHI-PROJECT-15K09118
[Journal Article] Epicardial Adipose Tissue as a Predictor of Plaque Vulnerability in Patients With Mild Chronic Kidney Disease2016
- Author(s)
  Nohara A.
- Journal Title
  
  Circ J
  
  Volume: 80 Issue: 1 Pages: 64-66
- DOI
  10.1253/circj.CJ-15-1265
- NAID
  130005117012
- ISSN
  1346-9843, 1347-4820
- Language
  English
- Data Source
  KAKENHI-PROJECT-26461359
[Journal Article] Prevalence, clinical features, and prognosis of patients with extremely low high-density lipoprotein cholesterol.2016
- Author(s)
  Tada H, Kawashiri MA, Konno T, Nohara A, Inazu A, Mabuchi H, Yamagishi M, Hayashi K.
- Journal Title
  
  J Clin Lipidol.
  
  Volume: 10 Issue: 6 Pages: 1311-1317
- DOI
  10.1016/j.jacl.2016.08.005
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15K09118
[Journal Article] Lipoprotein(a) in Familial Hypercholesterolemia With Proprotein Convertase Subtilisin/Kexin Type 9 (<i>PCSK9</i>) Gain-of-Function Mutations2016
- Author(s)
  Tada H, Kawashiri MA, Yoshida T, Teramoto R, Nohara A, Konno T, Inazu A, Mabuchi H, Yamagishi M, Hayashi K.
- Journal Title
  
  Circ J
  
  Volume: 80 Issue: 2 Pages: 512-518
- DOI
  10.1253/circj.CJ-15-0999
- NAID
  130005120923
- ISSN
  1346-9843, 1347-4820
- Language
  English
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15K09118, KAKENHI-PROJECT-26460670
[Journal Article] Characterization of Autosomal Dominant Hypercholesterolemia Caused by PCSK9 Gain of Function Mutations and Its Specific Treatment With Alirocumab, a PCSK9 Monoclonal Antibody.2015
- Author(s)
  Hopkins PN, Defesche J, Fouchier SW, Yagi K, Krempf M, Swergold GD et. al.
- Journal Title
  
  Circ Cardiovasc Genet
  
  Volume: 8 Issue: 6 Pages: 823-831
- DOI
  10.1161/circgenetics.115.001129
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K08544, KAKENHI-PROJECT-15K09118, KAKENHI-PROJECT-26461359
[Journal Article] Exome sequencing in suspected monogenic dyslipidemias.2015
- Author(s)
  Stitziel NO, Peloso GM, Abifadel M, Cefalu AB, Fouchier S, Motazacker MM, Tada H, Larach DB, Awan Z, Haller JF, Pullinger CR, Varret M, Noto D, Tarugi P, Kawashiri MA, Nohara A, Yamagishi M, Kathiresan S. et al.
- Journal Title
  
  Circ Cardiovasc Genet.
  
  Volume: 8 Issue: 2 Pages: 343-50
- DOI
  10.1161/circgenetics.114.000776
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-24591041, KAKENHI-PROJECT-26893094, KAKENHI-PROJECT-15K09118, KAKENHI-PROJECT-26461359
[Journal Article] Functional Characterization of Rare Variants Implicated in Susceptibility to Lone Atrial Fibrillation.2015
- Author(s)
  Hayashi K, Konno T, Tada H, Tani S, Liu L, Fujino N, Nohara A, Hodatsu A, Tsuda T, Tanaka Y, Kawashiri MA, Ino H, Makita N, Yamagishi M.
- Journal Title
  
  Circ Arrhythm Electrophysiol.
  
  Volume: 8 Issue: 5 Pages: 1095-1104
- DOI
  10.1161/circep.114.002519
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15K09118, KAKENHI-PROJECT-26460670, KAKENHI-PROJECT-15K15311, KAKENHI-PROJECT-15H04823, KAKENHI-PROJECT-25460648, KAKENHI-PROJECT-25860589, KAKENHI-PROJECT-24390199
[Journal Article] Clinical characteristics of Japanese patients with severe hypertriglyceridemia2015
- Author(s)
  Tada H, Kawashiri MA, Nakahashi T, Yagi K, Chujo D, Ohbatake A, Mori Y, Mori S, Kometani M, Fujii H, Nohara A, Inazu A, Mabuchi H, Yamagishi M, Hayashi K.
- Journal Title
  
  J Clin Lipidol
  
  Volume: 9 Issue: 4 Pages: 519-524
- DOI
  10.1016/j.jacl.2015.05.004
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15K08544, KAKENHI-PROJECT-15K09118
[Journal Article] Whole exome sequencing combined with integrated variant annotation prediction identifies asymptomatic Tangier disease with compound heterozygous mutations in ABCA1 gene.2015
- Author(s)
  Tada H, Kawashiri MA, Nohara A, Saito R, Tanaka Y, Nomura A, Konno T, Sakata K, Fujino N, Takamura T, Inazu A, Mabuchi H, Yamagishi M, Hayashi K.
- Journal Title
  
  Atherosclerosis.
  
  Volume: 240 Issue: 2 Pages: 324-9
- DOI
  10.1016/j.atherosclerosis.2015.04.003
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-24591041, KAKENHI-PROJECT-15K09118, KAKENHI-PROJECT-26461329
[Journal Article] Therapy: PCSK9 inhibitors for treating familial hypercholesterolaemia2015
- Author(s)
  Mabuchi H, Nohara A.
- Journal Title
  
  Nat Rev Endocrinol
  
  Volume: 11 Issue: 1 Pages: 8-9
- DOI
  10.1038/nrendo.2014.205
- Data Source
  KAKENHI-PROJECT-26461359
[Journal Article] Extreme Contrast of Postprandial Remnant-Like Particles Formed in Abetalipoproteinemia and Homozygous Familial Hypobetalipoproteinemia.2015
- Author(s)
  Kawashiri MA, Tada H, Hashimoto M, Taniyama M, Nakano T, Nakajima K, Inoue T, Mori M, Nakanishi C, Konno T, Hayashi K, Nohara A, Inazu A, Koizumi J, Ishihara H, Kobayashi J, Hirano T, Mabuchi H, Yamagishi M.
- Journal Title
  
  JIMD Rep.
  
  Volume: in press Pages: 85-94
- DOI
  10.1007/8904_2015_415
- ISBN
  9783662474525, 9783662474532
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-24591041, KAKENHI-PROJECT-15K09118, KAKENHI-PROJECT-26461359
[Journal Article] Infantile Cases of Sitosterolaemia with Novel Mutations in the ABCG5 Gene: Extreme Hypercholesterolaemia is Exacerbated by Breastfeeding.2015
- Author(s)
  Tada H, Kawashiri MA, Takata M, Matsunami K, Imamura A, Matsuyama M, Sawada H, Nunoi H, Konno T, Hayashi K, Nohara A, Inazu A, Kobayashi J, Mabuchi H, Yamagishi M.
- Journal Title
  
  JIMD Rep.
  
  Volume: in press Pages: 115-122
- DOI
  10.1007/8904_2014_404
- ISBN
  9783662471715, 9783662471722
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24591041, KAKENHI-PROJECT-15K09118
[Journal Article] Genotypic and phenotypic features in homozygous familial hypercholesterolemia caused by proprotein convertase subtilisin/kexin type 9 (PCSK9) gain-of-function mutation2014
- Author(s)
  Mabuchi H, Nohara A, Noguchi T, Kobayashi J, Kawashiri MA, Inoue T, Mori M, Tada H, Nakanishi C, Yagi K, Yamagishi M, Ueda K, Takegoshi T, Miyamoto S, Inazu A, Koizumi J; The Hokuriku FH Study Group
- Journal Title
  
  Atherosclerosis
  
  Volume: 236 Issue: 1 Pages: 54-61
- DOI
  10.1016/j.atherosclerosis.2014.06.005
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-23590663, KAKENHI-PROJECT-24591041, KAKENHI-PROJECT-26461359
[Journal Article] Clinical significance of measuring soluble LR11, a circulating marker of atherosclerosis and HbA1c in familial hypercholesterolemia2014
- Author(s)
  Nohara A, Kobayashi J, Kawashiri M-A, Tada H, Inazu A, Jiang M, Mabuchi H, Bujo H.
- Journal Title
  
  Clinical Biochemistry
  
  Volume: in press
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23591334
[Journal Article] Nohara A, Kobayashi J , Kawashiri MA, Tada H, Inazu A, Jiang M, Mabuchi H, Bujo H. Clinical significance of measuring soluble LR11, a circulating marker of atherosclerosis and HbA1c in familial hypercholesterolemia2014
- Author(s)
  Nohara A, Kobayashi J , Kawashiri MA, Tada H, Inazu A, Jiang M, Mabuchi H, Bujo H
- Journal Title
  
  Clinical Biochemistry
  
  Volume: 47 Issue: 13-14 Pages: 1326-1328
- DOI
  10.1016/j.clinbiochem.2014.05.003
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-23590663, KAKENHI-PROJECT-23591334, KAKENHI-PROJECT-26461359
[Journal Article] Effects of coenzyme Q(10) on LDL oxidation in vitro2013
- Author(s)
  Ahmadvand H, Mabuchi H, Nohara A, Kobayahi J, Kawashiri MA
- Journal Title
  
  Acta Med Iran
  
  Volume: 51(1) Pages: 12-8
- URL
  http://acta.tums.ac.ir
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23591334
[Journal Article] MTP inhibitor for treating severe LDL cholesterolemia2013
- Author(s)
  Mabuchi H, Nohara A
- Journal Title
  
  Clinical Lipidology
  
  Volume: 8(4) Pages: 387-389
- URL
  http://www.futuremedicine.com
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23591334
[Journal Article] Impact of serum retinol-binding protein 4 levels on regulation of remnant-like particles triglyceride in type 2 diabetes mellitus2013
- Author(s)
  Yamaaki N, Yagi K, Kobayashi J, Nohara A, Ito N, Asano A, Nakano K, Liu J, Okamoto T, Mori Y, Ohbatake A, Okazaki S, Takeda Y, Yamagishi M
- Journal Title
  
  J Diabetes Res
  
  Volume: 2013 Pages: 143515-143515
- DOI
  10.1155/2013/143515
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23590663, KAKENHI-PROJECT-23591334
[Journal Article] Efficacy and safety of coadministration of rosuvastatin, ezetimibe, and colestimide in heterozygous familial hypercholesterolemia2012
- Author(s)
  Kawashiri MA, Nohara A, Noguchi T, Tada H, Nakanishi C, Mori M, Konno T, Hayashi K, Fujino N, Inazu A, Kobayashi J, Mabuchi H, Yamagishi M
- Journal Title
  
  Am J Cardiol
  
  Volume: 109 Issue: 3 Pages: 364-9
- DOI
  10.1016/j.amjcard.2011.09.019
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21591160, KAKENHI-PROJECT-22590808, KAKENHI-PROJECT-23590663, KAKENHI-PROJECT-23591334
[Journal Article] Novel mutations of cholesteryl ester transfer protein(CETP) gene in Japanese hyperalphalipoproteinemic subjects2012
- Author(s)
  Ohtani R, Inazu A, Noji Y, Wakasugi T, Miwa K, Tada H, Kawashiri MA, Noguchi T, Nohara A, Kobayashi J, Koizumi J, Yamagishi M, Mabuchi H
- Journal Title
  
  Clin Chim Acta
  
  Volume: 413 Issue: 5-6 Pages: 537-43
- DOI
  10.1016/j.cca.2011.11.010
- NAID
  120004026116
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21591160, KAKENHI-PROJECT-23590663, KAKENHI-PROJECT-23591334
[Journal Article] Altered metabolism of low-density lipoprotein and very-low-density lipoprotein remnant in autosomal recessive hypercholesterolemia : results from stable isotope kinetic study in vivo2012
- Author(s)
  Tada H, Kawashiri MA, Ikewaki K, Terao Y, Noguchi T, Nakanishi C, Tsuchida M, Takata M, Miwa K, Konno T, Hayashi K, Nohara A, Inazu A, Kobayashi J, Mabuchi H, Yamagishi M
- Journal Title
  
  Circ Cardiovasc Genet
  
  Volume: 5 Issue: 1 Pages: 35-41
- DOI
  10.1161/circgenetics.111.960948
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21591160, KAKENHI-PROJECT-23590663, KAKENHI-PROJECT-23591334
[Journal Article] Post-prandial remnant lipoprotein metabolism in autosomal recessive hypercholesterolaemia2012
- Author(s)
  Tada H
- Journal Title
  
  Eur J Clin Invest
  
  Volume: 42 Issue: 10 Pages: 1094-1099
- DOI
  10.1111/j.1365-2362.2012.02700.x
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590517, KAKENHI-PROJECT-23590663, KAKENHI-PROJECT-23591334, KAKENHI-PROJECT-24790748
[Journal Article] A novel type of familial hypercholesterolemia : double heterozygous mutations in LDL receptor and LDL receptor adaptor protein 1 gene2011
- Author(s)
  Tada H, Kawashiri MA, Ohtani R, Noguchi T, Nakanishi C, Konno T, Hayashi K, Nohara A, Inazu A, Kobayashi J, Mabuchi H, Yamagishi M
- Journal Title
  
  Atherosclerosis
  
  Volume: 219 Issue: 2 Pages: 663-6
- DOI
  10.1016/j.atherosclerosis.2011.08.004
- NAID
  120003368152
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21591160, KAKENHI-PROJECT-23590663, KAKENHI-PROJECT-23591334, KAKENHI-PROJECT-24591041
[Journal Article] Comparison of losartan versus ramipril on several adipocytokines and vascular remodeling biomarkers2011
- Author(s)
  Kobayashi j, Noguchi T, Nohara A, Mabuchi H.
- Journal Title
  
  Hypertens Res
  
  Volume: 34 Pages: 52-54
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590560
[Journal Article] Comparison of effects of bezafibrate and fenofibrate on circulating proprotein convertase subtilisin/kexin type 9 and adipocytokine levels in dyslipidemic subjects with impaired glucose tolerance or type 2 diabetes mellitus : results from a crossover study2011
- Author(s)
  Noguchi T, et al., 計14名、9番目
- Journal Title
  
  Atherosclerosis
  
  Volume: 217 Issue: 1 Pages: 165-170
- DOI
  10.1016/j.atherosclerosis.2011.02.012
- NAID
  120003141452
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21591160, KAKENHI-PROJECT-22590772, KAKENHI-PROJECT-23590663, KAKENHI-PROJECT-23591334
[Journal Article] 原発性脂質異常症の分子病態2011
- Author(s)
  小林淳二, 野口徹, 野原淳, 馬渕宏
- Journal Title
  
  Annual Review糖尿病代謝内分泌
  
  Pages: 127-133
- Data Source
  KAKENHI-PROJECT-20590560
[Journal Article] Retinoid X Receptor Heterodimer Variants and Cardiovascular Risk Factors2009
- Author(s)
  Atsushi Nohara
- Journal Title
  
  J Atheroscler Thromb (in press)
- NAID
  10025765899
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19591040
[Journal Article] Retinoid X receptor heterodimer variants and cardiovascular risk factors.2009
- Author(s)
  野原淳, 小林淳二, 馬渕宏
- Journal Title
  
  J Atheroscler Thromb 16
  
  Pages: 303-318
- NAID
  10025765899
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590560
[Journal Article] 肝性リパーゼ脂質検査アップデート2009
- Author(s)
  小林淳二, 今村茂行, 酒瀬川信一, 野口徹, 野原淳, 馬渕宏
- Journal Title
  
  Medical Technology 37巻
  
  Pages: 149-153
- Data Source
  KAKENHI-PROJECT-20590560
[Journal Article] Cholesterol efflux from J774 macrophages and Fu5AH hepatoma cells to serum is preserved in CETP-deficient patients2009
- Author(s)
  Kenji Miwa, Akihiro Inazu, Masa-aki Kawashiri, Atsushi Nohara(他2名)
- Journal Title
  
  Clin Chim Acta 402(1-2)
  
  Pages: 19-24
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19591040
[Journal Article] A novel method for determining functional LDL receptor activity in familial hypercholesterolemia : application of the CD3/CD28 assay in lymphocytes2009
- Author(s)
  Hayato Tada, Masa-aki Kawashiri, Tohru Noguchi, Mika Mori, Masayuki Tsuchida, Mutsuko Takata, Atsushi Nohara(他5名)
- Journal Title
  
  Clin Chim Acta 400(1-2)
  
  Pages: 42-7
- NAID
  120001063575
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19591040
[Journal Article] Apolipoprotein B gene mutations and fatty liver in Japanese hypobetalipoproteinemia2009
- Author(s)
  Shoji Katsuda, Masa-aki Kawashiri, Akihiro Inazu, Hayato Tada, Masayuki Tsuchida, Yoshibumi Kaneko, Tsuyoshi Nozue, Atsushi Nohara(他5名)
- Journal Title
  
  Clin Chim Acta 399(1-2)
  
  Pages: 64-8
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19591040
[Journal Article] 肝性リパーゼ脂質検査アップデート2009
- Author(s)
  小林淳二, 今村茂行, 酒瀬川信一, 野口徹, 野原淳, 馬渕宏
- Journal Title
  
  Medical Technology 37
  
  Pages: 149-153
- Data Source
  KAKENHI-PROJECT-20590560
[Journal Article] A novel method for measuring human lipoprotein lipase and hepatic lipase activities in post-heparin plasma.2008
- Author(s)
  Imamura S, Kobayashi J, Nakajima K, Sakasegawa S, Nohara A, Noguchi T, Kawashiri M, Inazu A, Deeb SS, Mabuchi H, Brunzell JD
- Journal Title
  
  Journal of Lipid Research 49
  
  Pages: 1431-1437
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590560
[Journal Article] Effects of CoQ10 supplementation on plasma lipoprotein lipid, CoQ10 and liver and muscle enzyme levels in hypercholesterolemic patients treated with atorvastatin : a randomized double-blind study2007
- Author(s)
  Hiroshi Mabuchi, Atsushi Nohara(他5名)
- Journal Title
  
  Atherosclerosis 195(2)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19591040
[Journal Article] The relationship of serum lipoprotein lipase mass with fasting serum apolipoprotein B-48 and remnant-like particle triglycerides in type 2 diabetic patients2007
- Author(s)
  Junji Kobayashi, Katsuyuki Nakajima, Atsushi Nohara(他6名)
- Journal Title
  
  Horm Metab Res 39(8)
  
  Pages: 612-6
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19591040
[Journal Article] High frequency of a retinoid X receptor gamma gene variant in familial combined hyperlipidemia that associates with atherogenic dyslipidemia.2007
- Author(s)
  Atsushi Nohara
- Journal Title
  
  Arterioscler Thromb Vasc Biol 27(4)
  
  Pages: 923-928
- Data Source
  KAKENHI-PROJECT-17790603
[Journal Article] Serum lipoprotein lipase mass : clinical significance of its measurement2007
- Author(s)
  Junji Kobayashi, Atsushi Nohara(他5名)
- Journal Title
  
  Clin Chim Acta 378(1-2)
  
  Pages: 7-12
- NAID
  120000810349
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19591040
[Journal Article] High frequency of a retinoid X receptor gamma gene variant in familial combined hyperlipidemia that associates with atherogenic dyslipidemia2007
- Author(s)
  Atsushi Nohara
- Journal Title
  
  Arterioscler Thromb Vasc Biol. 27
  
  Pages: 923-8
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19591040
[Journal Article] High frequency of a retinoid X receptor gamma gene variant in familial combined hyperlipidemia that associates with atherogenic dyslipidemia2007
- Author(s)
  Atsushi Nohara(他13名)
- Journal Title
  
  Arterioscler Thromb Vasc Biol 27(4)
  
  Pages: 923-8
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19591040
[Journal Article] RXRg Gene Variant is Associate with Lower HDL, Lower Lipoprotein Lipase, Advanced Coronary Artery Disease, and More Frequent in Familial Combined Hyperlipidemia2005
- Author(s)
  Nohara A
- Journal Title
  
  Circulation (Supplement) 112(17)
- Data Source
  KAKENHI-PROJECT-17790603
[Journal Article] Retinoid X Receptor Heterodimer Variants and Cardiovascular Risk Factors
- Author(s)
  Atsushi Nohara, (他2名)
- Journal Title
  
  J Atheroscler Thromb (in press)
- NAID
  10025765899
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19591040
[Presentation] History and Changes of Japanese FH guidelines2022
- Author(s)
  Atsushi Nohara
- Organizer
  1st JAS-KSoLA Joint Symposium on FH and Severe Dyslipidemia
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K09859
[Presentation] シンポジウム8：成人FHの診断基準、診療指針はどう変更されたか？2022
- Author(s)
  野原　淳
- Organizer
  第54回日本動脈硬化学会総会・学術集会
- Invited
- Data Source
  KAKENHI-PROJECT-17K09859
[Presentation] 第26回診断技術向上セミナー：家族性高コレステロール血症におけるアキレス腱計測の意義2021
- Author(s)
  野原　淳
- Organizer
  第53回日本動脈硬化学会総会・学術集会
- Data Source
  KAKENHI-PROJECT-17K09859
[Presentation] SYMPOSIUM 18：PCSK9 Inhibitors: Management of High-Risk for Cardiovascular Disease2021
- Author(s)
  Nohara A.
- Organizer
  The 19th International Symposium on Atherosclerosis
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K09859
[Presentation] FHと遺伝子変異―遺伝子変異と治療の選択―2020
- Author(s)
  野原　淳
- Organizer
  第41回日本アフェレシス学会学術大会
- Data Source
  KAKENHI-PROJECT-17K09859
[Presentation] SYMPOSIUM: Effect of PCSK9i on Lp(a)2019
- Author(s)
  Atsushi NOHARA
- Organizer
  The 12th ISFA2019 & The 40th JSFA2019
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K09859
[Presentation] 診断技術向上セミナー “Why” and “How” We Should Diagnose Familial Hypercholesterolemia with Standard Evaluation Method for Achilles Tendon Thickness2019
- Author(s)
  Atsushi NOHARA
- Organizer
  第51回日本動脈硬化学会総会・学術集会
- Invited
- Data Source
  KAKENHI-PROJECT-17K09859
[Presentation] Lysosomal Acid Lipase Activities Negatively Correlated with Cholesterol-esterification Rates in Statin Users, and were Lower with Common Functional Variant LIPA T16P Carriers in Heterozygous FH2019
- Author(s)
  Atsushi Nohara, Masa-aki Kawashiri, Yoshikatsu Eto, Hayato Tada, Mika Mori, Chiaki Nakanishi, Akihiro Inazu, Hiroshi Mabuchi
- Organizer
  2019 ASBMB Deuel Conference on Lipids
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K09859
[Presentation] 家族性高コレステロール血症の最新の診断と治療～FH遺伝子診断の有用性～2018
- Author(s)
  野原　淳
- Organizer
  第25回日本遺伝子診療学会
- Invited
- Data Source
  KAKENHI-PROJECT-17K09859
[Presentation] 日本動脈硬化学会　合同セッション　PSCK9阻害剤の臨床「家族性高コレステロール血症」2018
- Author(s)
  野原　淳
- Organizer
  第27回日本心血管インターベンション治療学会学術集会
- Invited
- Data Source
  KAKENHI-PROJECT-17K09859
[Presentation] CLINICAL IMPLICATION OF FH GENE TEST: DETECTION RATES IN LDLR AND PCSK9 GENES IN JAPAN2018
- Author(s)
  Atsushi Nohara, Masa-aki Kawashiri, Hayato Tada, Mika Mori, Chiaki Nakanishi, Akihiro Inazu, Hiroshi Mabuchi
- Organizer
  86th EAS Congress
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K09859
[Presentation] シンポジウム：FH awareness 「FHにおいて遺伝子診断をどのように役立てるか」2018
- Author(s)
  野原　淳
- Organizer
  第50回日本動脈硬化学会総会
- Invited
- Data Source
  KAKENHI-PROJECT-17K09859
[Presentation] シンポジウム2「脂質領域・動脈硬化領域におけるLDLアフェレシス治療の役割」2018
- Author(s)
  野原　淳
- Organizer
  第39回日本アフェレシス学会学術大会
- Invited
- Data Source
  KAKENHI-PROJECT-17K09859
[Presentation] シンポジウム4：家族性高コレステロール血症の診断と治療 -ガイドラインを踏まえて-2018
- Author(s)
  野原　淳
- Organizer
  第37回日本脳神経超音波学会
- Invited
- Data Source
  KAKENHI-PROJECT-17K09859
[Presentation] 家族性高コレステロール血症の診断2017
- Author(s)
  川尻剛照、多田隼人、野原淳、馬渕宏、山岸正和
- Organizer
  第49回日本動脈硬化学会総会・学術集会
- Invited
- Data Source
  KAKENHI-PROJECT-15K09118
[Presentation] COMMON FUNCTIONAL VARIANT LIPA T16P AFFECTS HDL COMPOSITION AMONG PATIENTS WITH HETEROZYGOUS FAMILIAL HYPERCHOLESTEROLEMIA2017
- Author(s)
  Atsushi Nohara, Masa-aki Kawashiri, Yoshikatsu Eto, Miwa Fujisaki, Hayato Tada, Mie Yoshida, Mika Mori, Chiaki Nakanishi, Kunimasa Yagi, Akihiro Inazu, Masakazu Yamagishi, Hiroshi Mabuchi
- Organizer
  European Atherosclerosis Society
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K09859
[Presentation] Impact of evolocumab, a PCSK9 inhibitor, withdrawing from regular LDL apheresis therapy in patients with heterozygous familial hypercholesterolemia2017
- Author(s)
  Kawashiri M, Higashikata T, Nohara A, Nakanishi C, Tada H, Okada H, Yamagishi M
- Organizer
  European Society of Cardiology 2017
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K09118
[Presentation] Impact of evolocumab, a PCSK9 inhibitor, withdrawing from regular LDL-apheresis therapy in patients with heterozygous familial hypercholesterolemia2017
- Author(s)
  Masaaki Kawashiri, Toshinori Higashikata, Atsushi Nohara, Chiaki Nakanishi, Hayato Tada, Hirofumi Okada, Masakazu Yamagishi
- Organizer
  第81回日本循環器学会学術集会
- Place of Presentation
  金沢
- Year and Date
  2017-03-17
- Data Source
  KAKENHI-PROJECT-15K09118
[Presentation] 冠動脈、脳血管疾患予防におけるコレステロール低下療法の意義2017
- Author(s)
  川尻剛照、多田隼人、野原淳、山岸正和
- Organizer
  第4回日本心血管脳卒中学会学術集会
- Invited
- Data Source
  KAKENHI-PROJECT-15K09118
[Presentation] Clinical Characteristics of Common PCSK9 Gain-of-Function E32K Variant with Higher TG Elevation, and Double Heterozygotes with Common PCSK9 Variants and LDLR mutations2016
- Author(s)
  Nohara A, Kawashiri M-A, Tada H, Yoshida M, Mori M, Nakanishi C, Yagi K, Inazu A, Yamaghishi M, Mabuchi H.
- Organizer
  84th European Atherosclerosis Society Congress 2016
- Place of Presentation
  Innsbruck
- Year and Date
  2016-05-29
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26461359
[Presentation] Clinical Characteristics of Double Heterozygotes With PCSK9 Gain-of-Function Mutations and LDLR Mutations2016
- Author(s)
  Nohara A, Kawashiri M-A, Tada H, Yoshida M, Mori M, Nakanishi C, Yagi K, Inazu A, Yamaghishi M, Mabuchi H.
- Organizer
  American Heart Association Scientific Sessions 2016
- Place of Presentation
  New Orleans
- Year and Date
  2016-12-12
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26461359
[Presentation] A patient with compound heterozygous familial hypercholesterolemia accompanied with supravalvular aortic stenosis detected by Whole Exome Sequencing2015
- Author(s)
  川尻剛照、多田隼人、井上健、中西千明、森三佳、野原淳、稲津明広、馬渕宏、山岸正和
- Organizer
  第47回日本動脈硬化学会総会・学術集会
- Place of Presentation
  仙台
- Year and Date
  2015-07-09
- Data Source
  KAKENHI-PROJECT-15K09118
[Presentation] Impact of Betatrophin (ANGPTL8) R59W Mutation For Future Diabetes2015
- Author(s)
  Nohara A, Kawashiri M,Hattori H, Iwasaki T, Liu J, Yagi K, Yoshida M, Tada H, Mori M, Nakanishi C, Inazu A, Kobayashi A, Yamagishi M, Mabuchi M.
- Organizer
  American Heart Association Scientific Sessions 2015
- Place of Presentation
  米国　オーランド
- Year and Date
  2015-11-07
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26461359
[Presentation] Genetic CETP Deficiency Associated With Lower Coronary Stenosis Index in Dyslipdemic Patients in Japan2014
- Author(s)
  Nohara A, Yoshida M, Okazaki S, Inoue T, Mori M, Nakanishi C, Kawashiri M-A, Yagi K, Inazu A, Yamagishi M, Mabuchi H.
- Organizer
  The 82nd Congress of the European Atherosclerosis Society
- Place of Presentation
  Madrid, Spain
- Data Source
  KAKENHI-PROJECT-23591334
[Presentation] Usefulness of FH Gene Test in Patients with Dyslipidemia2013
- Author(s)
  Nohara A, Ohtani R, Noguchi T, Inoue T, Mori M, Nakanishi C, Kawashiri MA, Yagi K, Inazu A, Yamagishi M, Mabuchi H
- Organizer
  第45回日本動脈硬化学会総会・学術集会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-23591334
[Presentation] シンポジウム３：日本における原発性高脂血症の現状　家族性高コレステロール血症の診断および治療の課題.2013
- Author(s)
  野原淳
- Organizer
  第45回日本動脈硬化学会総会・学術集会
- Place of Presentation
  東京・京王プラザ
- Invited
- Data Source
  KAKENHI-PROJECT-23591334
[Presentation] Common PCSK9 E32K Variant as Genetic Background of Familial Combined Hyperlipidemia2013
- Author(s)
  Nohara A, Noguchi T, Inoue T, Mori M, Nakanishi C, Kawashiri MA, Yagi K, Inazu A, Yamagishi M, Mabuchi H
- Organizer
  The 81st European Atherosclerosis Society Congress
- Place of Presentation
  Lyon, France
- Data Source
  KAKENHI-PROJECT-23591334
[Presentation] Common PCSK9 E32K Variant as Genetic Background of Familial Combined Hyperlipidemia.2013
- Author(s)
  Nohara A, Noguchi T, Inoue T, Mori M, Nakanishi C, Kawashiri MA, Yagi K, Inazu A, Yamagishi M, Mabuchi H.
- Organizer
  The 81st European Atherosclerosis Society Congress
- Place of Presentation
  Lyon, France
- Data Source
  KAKENHI-PROJECT-23591334
[Presentation] Usefulness of FH Gene Test in Patients with Dyslipidemia.2013
- Author(s)
  Nohara A, Ohtani R, Noguchi T, Inoue T, Mori M, Nakanishi C, Kawashiri MA, Yagi K, Inazu A, Yamagishi M, Mabuchi H.
- Organizer
  第45回日本動脈硬化学会総会・学術集会
- Place of Presentation
  東京・京王プラザ
- Data Source
  KAKENHI-PROJECT-23591334
[Presentation] シンポジウム3:日本における原発性高脂血症の現状家族性高コレステロール血症の診断および治療の課題2013
- Author(s)
  野原淳
- Organizer
  第45回日本動脈硬化学会総会・学術集会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-23591334
[Presentation] Common PCSK9 E32K Variant as Genetic Background of Familial Combined Hyperlipidemia2013
- Author(s)
  Nohara A, Noguchi T, Inoue T, Mori M, Nakanishi C, Kawashiri MA, Yagi K, Inazu A, Yamagishi M, Mabuchi H
- Organizer
  第77回日本循環器学会学術総会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-23591334
[Presentation] Triglyceride-Rich High-Density Lipoprotein Composition as Residual Risk Biomarker of Coronary Artery Disease Including Reduced eGFR and Pre-diabetes2012
- Author(s)
  Nohara A, Inazu A, Noguchi T, Tada H, Mori M, Nakanishi C, Kawashiri MA, Yagi K, Kobayashi J, Yamagishi M, Mabuchi H
- Organizer
  American Heart Association's Scientific Sessions
- Place of Presentation
  Los Angeles (USA)
- Data Source
  KAKENHI-PROJECT-23591334
[Presentation] Hypertriglyceridemia eliminates positive correlations of plasma CETP with LDL-C and with Lp(a)2012
- Author(s)
  Nohara A, Noguchi T, Tada H, Mori M, Nakanishi C, Kawashiri MA, Yagi K, Inazu A, Kobayashi J, Yamagishi M, Mabuchi H
- Organizer
  XVI International Symposium on Atherosclerosis 2012
- Place of Presentation
  Sydney, AUS
- Data Source
  KAKENHI-PROJECT-23591334
[Presentation] Triglyceride-Rich High-Density Lipoprotein Composition as Residual Risk Biomarker of Coronary Artery Disease Including Reduced eGFR and Pre-diabetes.2012
- Author(s)
  Nohara A, Inazu A, Noguchi T, Tada H, Mori M, Nakanishi C, Kawashiri MA, Yagi K, Kobayashi J, Yamagishi M, Mabuchi H.
- Organizer
  American Heart Association's Scientific Sessions, 2012
- Place of Presentation
  Los Angeles Convention Center, Los Angeles (USA)
- Data Source
  KAKENHI-PROJECT-23591334
[Presentation] Impact of ER-Stress Affecting Variant of XBP-1 Gene on Lipids, Diabetes, Chronic Kidney Disease, and Coronary Artery Disease.2012
- Author(s)
  Nohara A, Noguchi T, Tada H, Mori M, Nakanishi C, Kawashiri MA, Yagi K, Inazu A, Kobayashi J, Yamagishi M, Mabuchi H.
- Organizer
  American Heart Association's Scientific Sessions, 2012
- Place of Presentation
  Los Angeles Convention Center, Los Angeles (USA)
- Data Source
  KAKENHI-PROJECT-23591334
[Presentation] Hypertriglyceridemia eliminates positive correlations of plasma CETP with LDL-C and with Lp(a)2012
- Author(s)
  Nohara A, Noguchi T, Tada H, Mori M, Nakanishi C, Kawashiri M, Yagi K, Inazu A, Kobayashi J, Yamagishi M, Mabuchi H
- Organizer
  XVI International Symposium on Atherosclerosis
- Place of Presentation
  Sydney Convention and Exhibition Centre (Australia)
- Data Source
  KAKENHI-PROJECT-23591334
[Presentation] Impact of ER-Stress Affecting Variant of XBP-1 Gene on Lipids, Diabetes, Chronic Kidney Disease, and Coronary Artery Disease2012
- Author(s)
  Nohara A, Noguchi T, Tada H, Mori M, Nakanishi C, Kawashiri MA, Yagi K, Inazu A, Kobayashi J, Yamagishi M, Mabuchi H
- Organizer
  American Heart Association's Scientific Sessions, 2012
- Place of Presentation
  Los Angeles (USA)
- Data Source
  KAKENHI-PROJECT-23591334
[Presentation] HDL-C Was Negatively Associated with Achilles' Tendon Thickening among Genetically Confirmed Familial Hypercholesterolemia2012
- Author(s)
  Nohara A, Noguchi T, Tada H, Mori M, Nakanishi C, Kawashiri MA, Yagi K, Inazu A, Kobayashi J, Yamagishi M, Mabuchi H
- Organizer
  HDL Satellite Symposium 2012
- Place of Presentation
  Cairns, AUS
- Data Source
  KAKENHI-PROJECT-23591334
[Presentation] Impact of “Isolated” and “Non-isolated” Low Levels of HDL-C2012
- Author(s)
  Nohara A, Noguchi T, Tada H, Mori M, Nakanishi C, Kawashiri MA, Yagi K, Inazu A, Kobayashi J, Yamagishi M, Mabuchi H.
- Organizer
  第44回日本動脈硬化学会総会・学術集会
- Place of Presentation
  ヒルトン福岡シーホーク，福岡県
- Data Source
  KAKENHI-PROJECT-23591334
[Presentation] Normalizing Pre-β1-HDL Levels with Eicosapentaenoic Acid Add-on to Atorvastatin2012
- Author(s)
  Nohara A, Kobayashi J, Noguchi T, Tada H, Mori M, Nakanishi C, Kawashiri M, Yagi K, Inazu A, Yamagishi M, Mabuchi H
- Organizer
  第76回日本循環器学会総会・学術集会
- Place of Presentation
  福岡国際会議場(福岡)
- Data Source
  KAKENHI-PROJECT-23591334
[Presentation] シンポジウム・我が国に於ける家族性高コレステロール血症我が国に於けるFHの疫学とCHDへのリスク2011
- Author(s)
  野原淳,野口徹,小林淳二,多田隼人,森三佳,中西千明,川尻剛照,八木邦公,稲津明広,山岸正和,馬渕宏
- Organizer
  第43回日本動脈硬化学会総会・学術集会
- Place of Presentation
  札幌
- Data Source
  KAKENHI-PROJECT-23591334
[Presentation] シンポジウム・心血管疾患予防のための新しいバイオマーカーImpact of Triglyceride-Rich High-Density Lipoprotein Composition as a New Marker for Development of Angiographic Coronary Artery Disease2011
- Author(s)
  Nohara A, Inazu A, Noguchi T, Tada H, Mori M, Nakanishi C, Kawashiri M, Yagi K, Kobayashi J, Yamagishi M, Mabuchi H
- Organizer
  第75回日本循環器学会総会・学術集会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-23591334
[Presentation] シンポジウム・心血管疾患予防のための新しいバイオマーカー　Impact of Triglyceride-Rich High-Density Lipoprotein Composition as a New Marker for Development of Angiographic Coronary Artery Disease2011
- Author(s)
  Nohara A, Inazu A, Noguchi T, Tada H, Mori M, Nakanishi C, Kawashiri M, Yagi K, Kobayashi J, Yamagishi M, Mabuchi H
- Organizer
  第75回日本循環器学会総会・学術集会
- Place of Presentation
  パシフィコ横浜(横浜)
- Data Source
  KAKENHI-PROJECT-23591334
[Presentation] "Intra-Individual Variability" of Fasting Lipids in Primary Hyperlipidemia is Associated With Fatty Liver, Hyperapobetalipoproteinemia and Advanced Coronary Artery Disease, But Not With Insulin Resistance2011
- Author(s)
  Nohara A, Yagi K, Noguchi T, Tada H, Mori M, Nakanishi C, Kawashiri M, Inazu A, Kobayashi J, Yamagishi M, Mabuchi H
- Organizer
  American Diabetes Association 71st Scientific Sessions
- Place of Presentation
  San Diego Convention Center (USA)
- Data Source
  KAKENHI-PROJECT-23591334
[Presentation] Angiopoietin-like protein3とリポ蛋白リパーゼ活性、肝性リパーゼ活性との相関性2010
- Author(s)
  小林淳二, 中嶋克行, 野原淳, 馬渕宏
- Organizer
  第31回日本肥満学会総会
- Place of Presentation
  前橋テルサ(群馬県)
- Year and Date
  2010-10-01
- Data Source
  KAKENHI-PROJECT-20590560
[Presentation] Effect of Licorice flavonpoid oil on plasma lipids in subjects with abdominal obesity.2010
- Author(s)
  小林淳二, 大家理恵, 野原淳, et al.
- Organizer
  第42回日本動脈硬化学会総会
- Place of Presentation
  長良川国際会議場(岐阜県)
- Year and Date
  2010-07-15
- Data Source
  KAKENHI-PROJECT-20590560
[Presentation] Angiopoietin-like protein3とLPL活性、HTGL活性との相関性2010
- Author(s)
  小林淳二、中嶋克行、野原淳、馬渕宏
- Organizer
  第31回日本肥満学会総会
- Place of Presentation
  前橋テレサ(群馬県)
- Year and Date
  2010-10-01
- Data Source
  KAKENHI-PROJECT-20590560
[Presentation] 脂質異常者における肝性リパーゼと血清脂質との関係2009
- Author(s)
  小林淳二, 今村茂行, 大家理恵, 野原淳, 川尻剛照、馬渕宏
- Organizer
  第30回日本肥満学会総会
- Place of Presentation
  アクトシティ浜松(静岡県)
- Year and Date
  2009-10-09
- Data Source
  KAKENHI-PROJECT-20590560
[Presentation] Impact of Upstream Transcription Factor 1 Gene Variant on Genetically Confirmed Familial Hypercholesterolemia (K790X)2008
- Author(s)
  Atsushi Nohara
- Organizer
  81st American Heart Association 2008 Scientific Sessions
- Place of Presentation
  New Orleans, USA
- Year and Date
  2008-11-11
- Data Source
  KAKENHI-PROJECT-19591040
[Presentation] Impact of Upstream Transcription Factor 1 Gene Varianton Genetically Confirmed Familial Hypercholesterolemia (K790X)2008
- Author(s)
  Atsushi Nohara
- Organizer
  81st American Heart Association 2008 Scientific Sessions
- Place of Presentation
  New Orleans, USA
- Year and Date
  2008-11-11
- Data Source
  KAKENHI-PROJECT-19591040
[Presentation] 新たなリポ蛋白リパーゼ(LPL)活性、肝性リパーゼ (HL) 活性測定法の確立2008
- Author(s)
  小林淳二, 今村茂行, 中嶋克行, 野原淳, 川尻剛照, 植田成, 稲津明広, 山岸正和, 馬渕宏
- Organizer
  第40回日本動脈硬イヒ学会総会
- Place of Presentation
  つくば市
- Year and Date
  2008-07-10
- Data Source
  KAKENHI-PROJECT-20590560
[Presentation] Maximum Lipid-lowering Therapy for Familial Hypercholesterolemia : Efficacy and Safety with High-dose Statin, Resin and Ezetimibe2008
- Author(s)
  野原淳
- Organizer
  第72回日本循環器学会総会・学術集会
- Place of Presentation
  福岡
- Year and Date
  2008-03-29
- Data Source
  KAKENHI-PROJECT-19591040
[Presentation] RXRヘテロタイマー形成核内受容体多型と脂質・糖質代謝異常2008
- Author(s)
  野原淳
- Organizer
  第40回日本動脈硬化学会総会
- Place of Presentation
  つくば
- Year and Date
  2008-07-11
- Data Source
  KAKENHI-PROJECT-19591040
[Presentation] RXRヘテロダイマー形成核内受容体多型と脂質・糖質代謝異常2008
- Author(s)
  野原淳
- Organizer
  第40回日本動脈硬化学会総会
- Place of Presentation
  つくば
- Year and Date
  2008-07-11
- Data Source
  KAKENHI-PROJECT-19591040
[Presentation] 新たなリポ蛋白リパーゼ(LPO)活性、肝性リパーゼ(HO活性測定法の確立2008
- Author(s)
  小林淳二, 今村茂行, 中嶋克行, 野原淳, 川尻剛照, 小泉順二, 山岸正和, 馬渕宏, Brunzell JD
- Organizer
  第51回日本糖尿病学会総会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-20590560
[Presentation] Impact of common variant of bile acid receptor FXR gene on cardiovascular risk facotrs2007
- Author(s)
  Atsushi Nohara
- Organizer
  XVI International Symposiumon Drugs Affecting Lipid Metabolism
- Place of Presentation
  New York, USA
- Year and Date
  2007-10-05
- Data Source
  KAKENHI-PROJECT-19591040
[Presentation] Nuclear bile acid receptor gene variant improves efficacy of lipid-lowering therapy Arteriosclerosis2007
- Author(s)
  Atsushi Nohara
- Organizer
  Thrombosis and Vascular Biology Annual Conference 2007
- Place of Presentation
  Chicago, USA
- Year and Date
  2007-04-19
- Data Source
  KAKENHI-PROJECT-19591040
[Presentation] Nuclear bile acid receptor gene variant improves efficacy of lipid-lowering therapy2007
- Author(s)
  Atsushi Nohara
- Organizer
  Arteriosclerosis, Thrombosis and Vascular Biology Annual Conference 2007
- Place of Presentation
  Chicago, USA
- Year and Date
  2007-04-19
- Data Source
  KAKENHI-PROJECT-19591040
[Presentation] RXRヘテロダイマー形成核内受容体多型と脂質低下療法2007
- Author(s)
  野原淳
- Organizer
  第39回日本動脈硬化学会総会・学術集会
- Place of Presentation
  大阪
- Year and Date
  2007-07-14
- Data Source
  KAKENHI-PROJECT-19591040
[Presentation] Impact of common variant of bile acid receptor FXR gene on cardiovascular risk facotrs2007
- Author(s)
  Atsushi Nohara
- Organizer
  XVI International Symposium on Drugs AffectingL ipid Metabolism
- Place of Presentation
  New York, USA
- Year and Date
  2007-10-05
- Data Source
  KAKENHI-PROJECT-19591040
[Presentation] RXRヘテロダイマ-形成核内受容体多型と脂質低下療法2007
- Author(s)
  野原淳
- Organizer
  第39回日本動脈硬化学会総会・学術集会
- Place of Presentation
  大阪
- Year and Date
  2007-07-14
- Data Source
  KAKENHI-PROJECT-19591040
[Presentation] Impact of Loss of Function Variant of Betatrophin on Advanced Coronary Artery Disease Among Diabetic Patients in Japan
- Author(s)
  Nohara A, Yagi K, Liu J, Ohbatake A, Okazaki S, Yoshida M, Mori M, Nakanishi C, Tada H, Kawashiri M-A, Inazu A, Yamaghishi M, Mabuchi H.
- Organizer
  82nd European Atherosclerosis Society Congress
- Place of Presentation
  Madrid, Spain
- Year and Date
  2014-05-31 – 2014-06-03
- Data Source
  KAKENHI-PROJECT-26461359
[Presentation] Metabolic Burden Switches Impact of Betatrophin (ANGPTL8) R59W Mutation From Atheroprotective to Atherogenic Lipid Profiles
- Author(s)
  Nohara A, Yagi K, Liu J, Ohbatake A, Okazaki S, Yoshida M, Mori M, Nakanishi C, Tada H, Kawashiri M-A, Inazu A, Yamaghishi M, Mabuchi H.
- Organizer
  American Heart Association Scientific Sessions 2014
- Place of Presentation
  Chicago, USA
- Year and Date
  2014-11-15 – 2014-11-19
- Data Source
  KAKENHI-PROJECT-26461359
[Presentation] Genetic CETP Deficiency Associated With Higher eGFR and Lower Coronary Stenosis Index in Dyslipdemic Patients in Japan
- Author(s)
  Nohara A, Inazu A, Okazaki S, Yoshida M, Mori M, Nakanishi C, Tada H, Kawashiri M-A, Yagi K, Yamaghishi M, Mabuchi H.
- Organizer
  American Heart Association Scientific Sessions 2014
- Place of Presentation
  Chicago, USA
- Year and Date
  2014-11-15 – 2014-11-19
- Data Source
  KAKENHI-PROJECT-26461359

1. INAZU Akihiro (80293348)

# of Collaborated Projects: 3 results

# of Collaborated Products: 26 results
2. KOBAYASHI Junji (60302577)

# of Collaborated Projects: 2 results

# of Collaborated Products: 30 results
3. YAGI Kunimasa (30293343)

# of Collaborated Projects: 2 results

# of Collaborated Products: 27 results
4. NOGUCHI Tohru (40456421)

# of Collaborated Projects: 1 results

# of Collaborated Products: 23 results
5. OKAZAKI Satoko (80613744)

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
6. Kawashiri Masaaki (90345637)

# of Collaborated Projects: 1 results

# of Collaborated Products: 25 results
7. 多田隼人 (90623653)

# of Collaborated Projects: 1 results

# of Collaborated Products: 19 results
8. HAYASHI Kenshi

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
9. YAMAGISHI Masakazu

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
10. USUI Soichiro

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
11. 高村雅之

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
12. 藤野陽

# of Collaborated Projects: 0 results

# of Collaborated Products: 3 results
13. 野村章洋

# of Collaborated Projects: 0 results

# of Collaborated Products: 4 results
14. 堀美香

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
15. 池脇克則

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

nohara atsushi 野原 淳

NOHARA Atsushi 野原 淳

野原 淳 ノハラ アツシ

Research Projects

Research Products

Co-Researchers

代謝異常関連脂肪肝におけるANGPTL8および小胞体ストレスの役割と先制医療の可能性Principal Investigator

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Review Section

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Roles of Lysosomal Acid Lipase in Development of Coronary Artery DiseasePrincipal Investigator

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Discovery and mechanistic analysis of a novel molecule associated with high-density lipoprotein metabolism using whole exome sequencing

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ANGPTL8 function and development of coronary artery diseasePrincipal Investigator

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High-density lipoprotein composition and development of coronary artery diseasePrincipal Investigator

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Novel method of measuring activities of enzymes involved in lipid metabolism

Principal Investigator

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Regulation of Cardiovascular Risk Factors by Metabolism-associated Nuclear ReceptorsPrincipal Investigator

Principal Investigator

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代謝関連核内受容体遺伝子変異機能解析と肥満および脂質代謝異常Principal Investigator

Principal Investigator

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核内受容体PPAR-α遺伝子変異体機能解析と脂質代謝異常Principal Investigator

Principal Investigator

Project Period (FY)

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Research Institution

[Journal Article] Impact of High-Density Lipoprotein Function, Rather Than High-Density Lipoprotein Cholesterol Level, on Cardiovascular Disease Among Patients With Familial Hypercholesterolemia2023

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[Journal Article] Attainment of the low-density lipoprotein cholesterol treatment target and prognosis of heterozygous familial hypercholesterolemia2023

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[Journal Article] Impact of Healthy Lifestyle in Patients With Familial Hypercholesterolemia2023

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[Journal Article] Effects of Different Types of Pathogenic Variants on Phenotypes of Familial Hypercholesterolemia2022

Author(s)

nohara atsushi 野原淳

NOHARA Atsushi 野原淳

野原淳ノハラアツシ