HAGIMOTO Naoki 萩本直樹

Researcher Number	50315074
Affiliation *help	2000 – 2003 : KYUSHU UNIVERSITY , Faculty of Med, Ass.Prof., 大学院・医学研究院, 助手 2002 : 九州大学, 医学研究院, 助手 2000 : 九州大学, 医学研究院, 助手 1999 : 九州大学, 医学部, 助手
Review Section/Research Field	Principal Investigator Respiratory organ internal medicine / Respiratory organ internal medicine Except Principal Investigator Respiratory organ internal medicine / Respiratory organ internal medicine
Keywords	Principal Investigator p21 / アポトーシス / caspase / 肺線維症 / apoptosis / Fas / bronchiolar epithelial cell / TGF-beta / lung injury / 肺腺維症 … More Except Principal Investigator pulmonary fibrosis / apoptosis / アポトーシス / 肺損傷 / lung injury / 肺線維症 / SUMO1 / p21 / TNF-alpha / Fas / TGF-beta / MDM2 / p53 / mitochondria / 肺線維化 / 肺気腫 / アデノウイルス / ERストレス / 肺維症 / プロテアソーム / p27 / サイトカイン / ER stress / ubiquitin / lung fibroblast / FLIP / 急性肺損傷 / Pulmonary emphysema / ユビキチン / ビタミンA / 肺上皮細胞 / カスパーゼ / シゲナル伝達 / Fasリガンド / Chemokine / Vitamin A / lung epithelium / Fas抗原 / ケモカイン / 小胞体ストレス / 肺線維芽細胞 / proteasome Less

Investigation of p21 in the molecular mechanisms of lung injury and pulmonary fibrosisPrincipal Investigator
- Principal Investigator
  
  FUJITA Masaki, 萩本直樹
- Project Period (FY)
  2003 – 2004
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Respiratory organ internal medicine
- Research Institution
  KYUSHU UNIVERSITY
Involvement of ER stress in the molecular mechanisms of lung injury and pulmonary fibrosis
- Principal Investigator
  
  KUWANO Kazuyoshi
- Project Period (FY)
  2003 – 2004
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Respiratory organ internal medicine
- Research Institution
  KYUSHU UNIVERSITY
The role of chronic inflammation on the pathogenesis for COPD, focusing on TNF-alpha.
- Principal Investigator
  
  FUJITA Masaki
- Project Period (FY)
  2002 – 2003
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Respiratory organ internal medicine
- Research Institution
  Kyushu University
To investigate the molecular mechanisms of pulmonary fibrosis and the development of treatment strategy
- Principal Investigator
  
  HARA Nobuyuki
- Project Period (FY)
  2001 – 2002
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Respiratory organ internal medicine
- Research Institution
  Kyushu University
Ubiquitin-proteasome system in the molecular mechanisms of lung injury and pulmonary fibrosis
- Principal Investigator
  
  KUWANO Kazuyoshi
- Project Period (FY)
  2001 – 2002
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Respiratory organ internal medicine
- Research Institution
  Kyushu University
The mechanisms of TGF-beta-induced apoptosis on lung epithelial cellsPrincipal Investigator
- Principal Investigator
  
  HAGIMOTO Naoki
- Project Period (FY)
  2000 – 2001
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Respiratory organ internal medicine
- Research Institution
  KYUSHU UNIVERSITY
Bronchiolar and alveolar epithelial cell apoptosis in pulmonary fibrosis
- Principal Investigator
  
  KUWANO Kazuyoshi
- Project Period (FY)
  1997 – 2000
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Respiratory organ internal medicine
- Research Institution
  KYUSHU UNIVERSITY

All 2004 2003 Other

All Journal Article

[Journal Article] Retinoic acid fails to reverse emphysema in adult mouse models.2004
- Author(s)
  Fujita M, Ye Q, Ouchi H, Nakashima N, Hamada N, Hagimoto N, Kuwano K, Mason RJ, Nakanishi Y.
- Journal Title
  
  Thorax 59
  
  Pages : 224-230
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15590813
[Journal Article] The role of apoptosis in pulmonary fibrosis.2004
- Author(s)
  Kuwano K., Hagimoto N., Nakanishi Y
- Journal Title
  
  Histol Histopathol 19
  
  Pages : 867-881
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15590813
[Journal Article] The perforin-mediated apoptotic pathway in lung injury and fibrosis.2004
- Author(s)
  Miyazaki H, Kuwano K, Yoshida K, Maeyama T, Yoshimi M, Fujita M, Hagimoto N, Yoshida R, Nakanishi Y
- Journal Title
  
  J Clin Pathol 57
  
  Pages : 1292-1298
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15590813
[Journal Article] Apoptosis signaling pathways as therapeutic targets in lung injury.2004
- Author(s)
  Kuwano K, Hagimoto N, Yoshimi M, Maeyama T, Nakanishi Y
- Journal Title
  
  Letters in Drug Design & Discovery 1
  
  Pages : 263-268
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15590813
[Journal Article] Induction of CDK inhibitor p21 gene as a new therapeutic strategy against pulmonary fibrosis.2004
- Author(s)
  Inoshima I, Kuwano K, Hamada N, Yoshimi M, Maeyama T, Hagimoto N, Nakanishi Y, Hara N
- Journal Title
  
  Am J Physiol Lung Cell Mol Physiol 286
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15590813
[Journal Article] Apoptosis signaling pathways as therapeutic targets in lung injury.2004
- Author(s)
  Kuwano K, Hagimoto N, Yoshimi M, Maeyama T, Nakanishi Y
- Journal Title
  
  Letters in Drug Design & Discovery 1
  
  Pages : 263-268
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15590815
[Journal Article] Cytoprotective strategy against pulmonary fibrosis.2004
- Author(s)
  Kuwano K, Hagimoto N, Yoshimi M, Maeyama T, Nakanishi Y
- Journal Title
  
  Drug Design Reviews 1
  
  Pages : 29-35
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15590813
[Journal Article] Anti-monocyte chemoattractant protein-1 gene therapy attenuates pulmonary fibrosis in mice.2004
- Author(s)
  Inoshima I, Kuwano K, Hamada N, Hagimoto N, Yoshimi M, Maeyama T, Takeshita A, Kitarnoto S, Egashira K, Hara N
- Journal Title
  
  Am J Physiol Lung Cell Mol Physiol 286
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15590813
[Journal Article] Induction of CDK inhibitor p21 gene as a new therapeutic strategy against pulmonary fibrosis.2004
- Author(s)
  Inoshima I, Kuwano K, Hamada N, Yoshimi M, Maeyama T, Hagimoto N, Nakanishi Y, Hara N
- Journal Title
  
  Am J Physiol Lung Cell Mol Physiol 286
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15590815
[Journal Article] Anti-monocyte chemoattractant protein-1 gene therapy attenuates pulmonary fibrosis in mice.2004
- Author(s)
  Inoshima I, Kuwano K, Hamada N, Hagimoto N, Yoshimi M, Maeyama T, Takeshita A, Kitarnoto S, Egashira K, Hara N
- Journal Title
  
  Am J Physiol Lung Cell Mol Physiol 286
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15590815
[Journal Article] Retinoic acid fails to reverse emphysema in adult mouse models.2004
- Author(s)
  Fujita M, Ye Q, Ouchi H, Nakashima N, Hamada N, Hagimoto N, Kuwano K, Mason RJ, Nakanishi Y.
- Journal Title
  
  Thorax 59
  
  Pages : 224-230
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15590815
[Journal Article] The role of apoptosis in pulmonary fibrosis.2004
- Author(s)
  Kuwano K., Hagimoto N., Nakanishi Y
- Journal Title
  
  Histol Histopathol 19
  
  Pages : 867-881
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15590815
[Journal Article] Cytoprotective strategy against pulmonary fibrosis.2004
- Author(s)
  Kuwano K, Hagimoto N, Yoshimi M, Maeyama T, Nakanishi Y
- Journal Title
  
  Drug Design Reviews 1
  
  Pages : 29-35
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15590815
[Journal Article] The perforin-mediated apoptotic pathway in lung injury and fibrosis.2004
- Author(s)
  Miyazaki H, Kuwano K, Yoshida K, Maeyama T, Yoshimi M, Fujita M, Hagimoto N, Yoshida R, Nakanishi Y
- Journal Title
  
  J Clin Pathol 57
  
  Pages : 1292-1298
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15590815
[Journal Article] Oxidative stress in lung epithelial cells from patients with idiopathic interstitial pneumonias.2003
- Author(s)
  Kuwano K.Hagimoto N, Nakashima N, Fujita M, Yoshimi M, Maeyama T, Inoshima I, Hamada N, Watanabe K, Hara N
- Journal Title
  
  Eur Respir J 21
  
  Pages : 232-240
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15590813
[Journal Article] Oxidative stress in lung epithelial cells from patients with idiopathic interstitial pneumonias.2003
- Author(s)
  Kuwano K.Hagimoto N, Nakashima N, Fujita M, Yoshimi M, Maeyama T, Inoshima I, Hamada N, Watanabe K, Hara N
- Journal Title
  
  Eur Respir J 21
  
  Pages : 232-240
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15590815
[Journal Article] The p53-Mdm2 association in epithelial cells in idiopathic pulmonary fibrosis and nonspecific interstitial pneumonia
- Author(s)
  Nakashima N, Kuwano K, Maeyama T, Hagimoto N, Yoshimi M, Hamada N, Yamada M, Nakanishi Y
- Journal Title
  
  J Clin Pathol (in press)
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15590813
[Journal Article] Anti-vascular endothelial growth factor gene therapy attenuates lung injury and fibrosis in mice.
- Author(s)
  Hamada N, Kuwano K, Yamada M, Hagimoto N, Hiasa K, Egashira K, Nakashima N, Maeyama T, Yoshimi M, Nakanishi Y
- Journal Title
  
  J Immunol (in press)
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15590813
[Journal Article] The p53-Mdm2 association in epithelial cells in idiopathic pulmonary fibrosis and nonspecific interstitial pneumonia
- Author(s)
  Nakashima N, Kuwano K, Maeyama T, Hagimoto N, Yoshimi M, Hamada N, Yamada M, Nakanishi Y
- Journal Title
  
  J Clin Pathol (in press)
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15590815
[Journal Article] Anti-vascular endothelial growth factor gene therapy attenuates lung injury and fibrosis in mice.
- Author(s)
  Hamada N, Kuwano K, Yamada M, Hagimoto N, Hiasa K, Egashira K, Nakashima N, Maeyama T, Yoshimi M, Nakanishi Y
- Journal Title
  
  J Immunol (in press)
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15590815

1. KUWANO Kazuyoshi (40205266)

# of Collaborated Projects : 7results

# of Collaborated Products : 20results
2. FUJITA Masaki (50325461)

# of Collaborated Projects : 6results

# of Collaborated Products : 6results
3. HARA Nobuyuki (90038802)

# of Collaborated Projects : 1results

# of Collaborated Products : 0results
4. SUEISHI Katsuo (70108710)

# of Collaborated Projects : 1results

# of Collaborated Products : 0results
5. 川崎雅之 (90264051)

# of Collaborated Projects : 1results

# of Collaborated Products : 0results
6. 田中拓夫

# of Collaborated Projects : 1results

# of Collaborated Products : 0results
7. 金子由美

# of Collaborated Projects : 1results

# of Collaborated Products : 0results

HAGIMOTO Naoki 萩本 直樹

Research Projects

Research Products

Co-Researchers

Investigation of p21 in the molecular mechanisms of lung injury and pulmonary fibrosisPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Involvement of ER stress in the molecular mechanisms of lung injury and pulmonary fibrosis

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

The role of chronic inflammation on the pathogenesis for COPD, focusing on TNF-alpha.

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

To investigate the molecular mechanisms of pulmonary fibrosis and the development of treatment strategy

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Ubiquitin-proteasome system in the molecular mechanisms of lung injury and pulmonary fibrosis

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

The mechanisms of TGF-beta-induced apoptosis on lung epithelial cellsPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Bronchiolar and alveolar epithelial cell apoptosis in pulmonary fibrosis

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Retinoic acid fails to reverse emphysema in adult mouse models.2004

Author(s)

Journal Title

Description

Data Source

[Journal Article] The role of apoptosis in pulmonary fibrosis.2004

Author(s)

Journal Title

Description

Data Source

[Journal Article] The perforin-mediated apoptotic pathway in lung injury and fibrosis.2004

Author(s)

Journal Title

Description

Data Source

[Journal Article] Apoptosis signaling pathways as therapeutic targets in lung injury.2004

Author(s)

Journal Title

Description

Data Source

[Journal Article] Induction of CDK inhibitor p21 gene as a new therapeutic strategy against pulmonary fibrosis.2004

Author(s)

Journal Title

Description

Data Source

[Journal Article] Apoptosis signaling pathways as therapeutic targets in lung injury.2004

Author(s)

Journal Title

Description

Data Source

[Journal Article] Cytoprotective strategy against pulmonary fibrosis.2004

Author(s)

Journal Title

Description

HAGIMOTO Naoki 萩本直樹