TSUKAZAKI Tomoo 塚崎智雄

Researcher Number	50315230
Other IDs
External Links
Affiliation (based on the past Project Information) *help	2002 – 2004: Graduate School of Biomedical Sciences, Associate Professor, 大学院・医歯薬学総合研究科, 助教授 2001 – 2002: Department of Oral Pathology, Nagasaki University School of Dentistry, Associate Professor, 歯学部, 助教授 2000: 長崎大学, 医学部, 助手 2000: 長崎大学, 医学部, 講師
Review Section/Research Field	Principal Investigator Biological Sciences / Orthopaedic surgery / Functional basic dentistry Except Principal Investigator Orthopaedic surgery / Biological Sciences / 病態科学系歯学(含放射線系歯学) / Circulatory organs internal medicine / Gastroenterology / Endocrinology / Morphological basic dentistry / Orthopaedic surgery
Keywords	Principal Investigator Runx2 / Notch / TGFβ / SARA / Smad / FYVEドメイン / シグナル伝達 / 発癌 / 発生・分化 / 分子進化 … More / 骨構造 / アフリカツメガエル / 歯牙発生 / 骨芽細胞 / 歯芽発生 / Notch1 / DNAチップ / プロテオミクス / tooth development / osteoblast … More Except Principal Investigator 骨再生 / Runx2 / 細胞分化 / 骨芽細胞 / 骨形成 / 間葉系幹細胞 / BMP / GFP / 再生 / 再生療法 / シグナル伝達 / 幹細胞 / TGF-β / MAPK / Smad / Norepinephrine / 変形性関節症 / インシュリン様成長因子(IGF) / IGF結合蛋白 / 関節軟骨 / CCN3 / Notch / bone regeneration / 細胞移植 / Cart1 / スプライシングバリアント / 軟骨分化 / ホメオボックス / 2量体形成 / 歯周組織 / 歯根膜細胞 / 心線維化 / 心肥大 / ノルエピネフリン / Ca拮抗薬 / 心線維芽細胞 / Smad系 / MAPK系 / Cardiac Fibrosis / Cardiac Hypertrophy / Ca antagonist / Signal Transduction / IGF-結合蛋白 / Insulin like growth factor / IGF binding protein / chondrocytes / Cartilage tissue / 肝細胞癌 / 脱分化 / アポトーシス / 分子標的 / 放射線 / 肝細胞 / 肝癌 / 前癌病変 / HUMARA assay / Hepatoma / Stem Cell / Carcinogenesis / Apoptosis / MEKK / Radiation / 甲状腺癌 / 癌遺伝子 / クローニング / Thyroid Cancer / Oncogene / Cloning / 慢性関節リウマチ / アンギオポイエチン / Tie-2レセプター / Tie 2レセプター / Angiopoietin / Tie-2 receptor / Rheumatoid arthritis / カエル / 進化 / アフリカツメガエル / 軟骨内骨化 / 両生類 / osteoblast / Mesenchymal stem cell / frog / evolution / TNF-alpha / TNFレセプター / ノックアウトマウス / 破骨細胞 / 骨形態計測 / pQCT / TNF receptor / knock-out mice / osteoclasts / インターロイキン / osteoarthritis / Insulin-like growth factor / interleukin-1β / articular cartilage / 骨欠損 / 遺伝子導入 / 遺伝子治療 / BMP-2 / Bone defect / gene transfer Less

脊椎動物における骨転写因子Runx2の分子進化と骨微細構造の獲得Principal Investigator
- Principal Investigator
  
  柴田恭明, 塚崎智雄
- Project Period (FY)
  2004 – 2005
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  Orthopaedic surgery
- Research Institution
  Nagasaki University
gene therapy for massive bone defects : Development of the delivery system for clinical use
- Principal Investigator
  
  SHINDO Hiroyuki
- Project Period (FY)
  2003 – 2004
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Orthopaedic surgery
- Research Institution
  Nagasaki University
歯周組織幹細胞(Periodontal Stem Cell)は存在するか?
- Principal Investigator
  
  山口朗
- Project Period (FY)
  2002 – 2003
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  病態科学系歯学(含放射線系歯学)
- Research Institution
  Nagasaki University
Comprehensive analysis of bone formation and its application
- Principal Investigator
  
  YAMAGUCHI Akira
- Project Period (FY)
  2002 – 2006
- Research Category
  
  Grant-in-Aid for Scientific Research (S)
- Research Field
  
  Morphological basic dentistry
- Research Institution
  Tokyo Medical and Dental University
  Nagasaki University
Comprehensive approach to identify novel molecules involved in osteogenesis and chondrogenesis during tooth development.Principal Investigator
- Principal Investigator
  
  TSUKAZAKI Tomoo
- Project Period (FY)
  2002 – 2004
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Functional basic dentistry
- Research Institution
  Nagasaki University
Functional analysis of TNF signaling in bone metabolism using knocked-out mice of type I and II TNF receptors.
- Principal Investigator
  
  ENOMOTO Hiroshi
- Project Period (FY)
  2002 – 2003
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Orthopaedic surgery
- Research Institution
  Nagasaki University
The regulation mechanism of cartilage destruction m osteoarthritis
- Principal Investigator
  
  MATSUMOTO Tomoko
- Project Period (FY)
  2002 – 2003
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Orthopaedic surgery
- Research Institution
  Nagasaki University
Molecular Analysis of Stem Cell in Hepatocarcinogenesis
- Principal Investigator
  
  OHTSURU Akira
- Project Period (FY)
  2001 – 2002
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Gastroenterology
- Research Institution
  Nagasaki University School of Medicine
Cloning and functional analysis of new oncogene in thyroid cancer
- Principal Investigator
  
  NANBA Hiroyuki
- Project Period (FY)
  2001 – 2002
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Endocrinology
- Research Institution
  Nagasaki University
Angiopoietin/Tie2 system in rheumatoid arthritis
- Principal Investigator
  
  SHINDO Hiroyuki
- Project Period (FY)
  2001 – 2002
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Orthopaedic surgery
- Research Institution
  Nagasaki University
骨芽細胞の分化調節機構を基盤として新しい骨再生療法を開発する
- Principal Investigator
  
  YAMAGUCHI Akira
- Project Period (FY)
  2000 – 2004
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Tokyo Medical and Dental University
  Nagasaki University
TGFβ情報伝達におけるレセプター複合体形成異常と発癌機構Principal Investigator
- Principal Investigator
  
  塚崎智雄
- Project Period (FY)
  2000
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas (C)
- Review Section
  
  Biological Sciences
- Research Institution
  Nagasaki University
ホメオボックス遺伝子Cart1の軟骨分化誘導能と発現形式の解析
- Principal Investigator
  
  朝長匡
- Project Period (FY)
  2000
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  Orthopaedic surgery
- Research Institution
  Nagasaki University
The Molecular Mechanisms of Cell Specific TGF-β Signal Transduction on Cardiac Fibrosis
- Principal Investigator
  
  ASHIZAWA Naoto
- Project Period (FY)
  2000 – 2001
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Circulatory organs internal medicine
- Research Institution
  Nagasaki University
The role of IGF-I and IGF-binding proteins in osteoarthritis
- Principal Investigator
  
  MATSUMOTO Tomoko
- Project Period (FY)
  2000 – 2001
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Orthopaedic surgery
- Research Institution
  Nagasaki University

All 2007 2005 2004 2003

All Journal Article

[Journal Article] BMP-2 promotes differentiation of osteoblasts and chondroblasts in Runx2-deficient cell lines.2007
- Author(s)
  Liu T, Gao Y, Sakamoto K, Minamizato T, Furukawa K, Tsukazaki T, Shibata Y, Bessho K, Komori T, Yamaguchi A
- Journal Title
  
  J Cell. Physiol 211
  
  Pages: 728-735
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-14104015
[Journal Article] BMP-2 promotes differentiation of osteoblasts and chondroblasts in Runx2-deficient cell lines.2007
- Author(s)
  Liu T, Gao Y, Sakamoto K, Minamizato T, Furukawa K, Tsukazaki T, Shibata Y, Bessho K, Komori T, Yamaguchi A
- Journal Title
  
  J Cell.Physiol 211
  
  Pages: 728-735
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14104015
[Journal Article] Critical regulation of BMP-induced osteoblastic differentiation by Deltal/Jaggedl-activated Notchl signaling.2005
- Author(s)
  Nobta M, Tsukazaki T, Shibata Y, Chang X, Moriishi T, Sakano S, Shindo H, Yamaguchi A
- Journal Title
  
  J Biol Chem 280
  
  Pages: 15842-15848
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-14104015
[Journal Article] Critical regulation of BMP-induced osteoblastic differentiation by Delta1/Jagged1-activated Notch1 signaling.2005
- Author(s)
  Nobuta M, Tsukazaki T, Shibata Y, Chang X, Moriishi T, Sakano S, Shindo H, Yamaguchi A
- Journal Title
  
  J Biol Chem 280
  
  Pages: 15842-15848
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14104015
[Journal Article] Critical regulation of BMP-induced osteoblastic differentiation by Delta1/Jagged1-activated Notch1 signaling.2005
- Author(s)
  Nobuta M, Tsukazaki T, Yamaguchi A, et al.
- Journal Title
  
  J.Biol.Chem. (in press)
- Data Source
  KAKENHI-PROJECT-14104015
[Journal Article] Expression profile of Xenopus banded hedgehog, a homolog of mouse Indian hedgehog, is related to the late development of endochondral ossification in Xenopus laevis2005
- Author(s)
  Moriishi T, Shibata Y, Tsukazaki T, Yamaguchi A
- Journal Title
  
  Biochem Biophys Res Commun 328
  
  Pages: 867-873
- Data Source
  KAKENHI-PROJECT-14104015
[Journal Article] Critical regulation of BMP-induced osteoblastic differentiation by Delta1/Jagged 1-activated Notch 1 signaling.2005
- Author(s)
  Nobuta M, Tsukazaki, Yamaguchi A, et al.
- Journal Title
  
  J.Biol.Chem. (in press)
- Data Source
  KAKENHI-PROJECT-12137208
[Journal Article] Expression profile of Xenopus banded hedgehog, a homolog of mouse Indian hedgehog, is related to the late development of endochondral ossification in Xenopus laevis.2005
- Author(s)
  Moriishi T, Shibata Y, Tsukazaki T, Yamaguchi A
- Journal Title
  
  Biochem Biophys Res Commun 328
  
  Pages: 867-873
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-14104015
[Journal Article] Critical regulation of BMP-induced osteoblastic differentiation by Delta1/Jagged1-activated Notch1 signaling..2005
- Author(s)
  Nobta M, Tsukazaki T, Shibata Y, Chang X, Moriishi T, Sakano S, Shindo H, Yamaguchi A
- Journal Title
  
  J.Biol.Chem 280
  
  Pages: 15842-15848
- Data Source
  KAKENHI-PROJECT-14104015
[Journal Article] Establishment of a clonal human mesenchymal cell line that retains multilineage differentiation capacity from a spinal hamartoma.2004
- Author(s)
  Doiguchi Y, Tsukazaki T, Tomonag T, Nobuta M, Fujita S, Hayashi T, Nagai K, Matsumoto T, Shindo H, Yamaguchi A
- Journal Title
  
  Cell Tissue Res 317
  
  Pages: 237-246
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-14104015
[Journal Article] Isolation and characterization of a mesenchymal cell line that differentiates into osteoblasts in response to BMP-2 from calvariae of GFP transgenic mice.2004
- Author(s)
  Kadowaki A, Tsukazaki T, Hirata K, Shibata Y, Okubo Y, Bessho K, Komori T, Yoshida N, Yamaguchi A
- Journal Title
  
  BONE 34
  
  Pages: 993-1003
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-14104015
[Journal Article] Isolation and characterization of a mesenchymal cell line that differentiates into osteoblasts in response to BMP-2 from calvariae GFP transgenic mice.2004
- Author(s)
  Kadowaki A, Tsukazaki T, Yoshida N, Yamaguchi A
- Journal Title
  
  BONE 34
  
  Pages: 993-1003
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14104015
[Journal Article] Role of a new member of IGFBP superfamily, IGFBP-rP10, in proliferation and differentiation of osteoblastic cells.2004
- Author(s)
  Shibata Y, Tsukazaki T, Hirata K, Cheng X, Yamaguchi A
- Journal Title
  
  Biochem Biophys Res Commun 325
  
  Pages: 1194-1200
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-14104015
[Journal Article] Establishment of a clonal human mesenchymal cell line that retains multilineage differentiation capacity from a spinal hamartoma.2004
- Author(s)
  Doiguchi Y, Tsukazaki T, Tomonaga T, Nobuta M, Fujita S, Hayashi T, Nagai K, Matsumoto T, Shindo H, Yamaguchi A
- Journal Title
  
  Cell Tissue Res 317
  
  Pages: 237-246
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14104015
[Journal Article] Transplantation of skin fibroblasts expressing BMP-2 promotes bone repair more effectively than those expressing Runx2.2003
- Author(s)
  Hirata K, Tsukazaki T, Kadowaki A, Furukawa K, Shibata Y, Moriishi T, Okubo Y, Bessho K, Komori T, Mizuno A, Yamaguchi A
- Journal Title
  
  Bone 32
  
  Pages: 502-512
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-14104015

1. YAMAGUCHI Akira (00142430)

# of Collaborated Projects: 6 results

# of Collaborated Products: 15 results
2. SHIBATA Yasuaki (80253673)

# of Collaborated Projects: 6 results

# of Collaborated Products: 10 results
3. NAGASAKI Ohtsuru (00233198)

# of Collaborated Projects: 4 results

# of Collaborated Products: 0 results
4. YAMASHITA Shunichi (30200679)

# of Collaborated Projects: 4 results

# of Collaborated Products: 0 results
5. MATSUMOTO Tomoko (30239107)

# of Collaborated Projects: 4 results

# of Collaborated Products: 0 results
6. SHINDO Hiroyuki (30107677)

# of Collaborated Projects: 4 results

# of Collaborated Products: 5 results
7. FUJITA Syuichi (00181355)

# of Collaborated Projects: 3 results

# of Collaborated Products: 2 results
8. ENOMOTO Hiroshi (90284679)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
9. KATSUBE Ken-ichi (20233760)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
10. SAKAMOTO Kei (00302886)

# of Collaborated Projects: 2 results

# of Collaborated Products: 2 results
11. NANBA Hiroyuki (80237635)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
12. TSURUMOTO Toshiyuki (60304937)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
13. OKANO Kunihiko (70325645)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
14. ASHIZAWA Naoto (10301368)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
15. YANO Katsusuke (50039864)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
16. SETO Shinji (00136657)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
17. NAKAO Kazuhiko (00264218)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
18. TAMAMURA Sadahiro (70431963)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
19. NEMOTO Takayuki (90164665)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
20. ITO Masako (10193517)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
21. 高橋弘 (20124597)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
22. 朝長匡 (00264242)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
23. 原宜興 (60159100)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results

TSUKAZAKI Tomoo 塚崎 智雄

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Co-Researchers

脊椎動物における骨転写因子Runx2の分子進化と骨微細構造の獲得Principal Investigator

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Comprehensive approach to identify novel molecules involved in osteogenesis and chondrogenesis during tooth development.Principal Investigator

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TGFβ情報伝達におけるレセプター複合体形成異常と発癌機構Principal Investigator

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TSUKAZAKI Tomoo 塚崎智雄