AMANO Hirofumi 天野浩文

Researcher Number	50318474
Other IDs
External Links
Affiliation (Current)	2025: 順天堂大学, 医学部, 先任准教授
Affiliation (based on the past Project Information) *help	2020 – 2024: 順天堂大学, 医学部, 先任准教授 2013 – 2019: 順天堂大学, 医学部, 准教授 2014: 順天堂大学大学, 医学部, 准教授 2007 – 2011: Juntendo University, 医学部, 准教授 2005 – 2006: 順天堂大学, 医学部, 助手
Review Section/Research Field	Principal Investigator 膠原病・アレルギー・感染症内科学 / Basic Section 54020:Connective tissue disease and allergy-related / Collagenous pathology/Allergology Except Principal Investigator Experimental pathology / Collagenous pathology/Allergology
Keywords	Principal Investigator 全身性エリテマトーデス / SLE / Fcレセプター / Yaa遺伝子 / TLR7 / モデルマウス / 遺伝子 / 疾患モデルマウス / マージナルゾーンB細胞 / 骨壊死 … More / 病態解明 / 可溶性TLR7 / 新規治療薬 / 新規治療 / TLR７ / 免疫学 / RA / IL-10 / FcγRIIB / 関節リウマチ / B細胞 / Fc_Yレセプター / BXSBマウス / Toll様受容体 / 様受容体 / Toll / Yaa / 単球・マクロファージ / 脾臓 / 全身性ループスエリテマトーデス / C3 / BXSB マウス … More Except Principal Investigator 全身性エリテマトーデス / Yaa / FcγRIIB / ループス腎炎 / 関節リウマチ / 胚中心 / 抑制性igG Fc受容体 / Yaa変異遺伝子 / リンパ濾胞胚中心 / 抑制性IgG Fc受容体 / 自己抗体産生B細胞 / RNA sequencing / 単球 / 細胞特異的遺伝子欠損 / 自己抗体 / Yaa遺伝子 / Slam遺伝子 / Fcレセプター / 自己免疫疾患 / 遺伝子 / 疾患モデルマウス / モデルマウス / Fc receptor / Slam / SLE / サイトカイン / 素因遺伝子 / 疾患感受性遺伝子 / 疾患感受性 / 疾患モデル Less

SLEに合併する骨壊死症のTLR7およびFcγⅡB受容体を標的とした発症阻止戦略Principal Investigator
- Principal Investigator
  
  天野浩文
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 54020:Connective tissue disease and allergy-related
- Research Institution
  Juntendo University
Elucidation of the pathology of SLE by TLR7 regulation and development of novel antibody therapeutics.Principal Investigator
- Principal Investigator
  
  Hirofumi Amano
- Project Period (FY)
  2019 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 54020:Connective tissue disease and allergy-related
- Research Institution
  Juntendo University
Role of IL-10 on phenotypical change from RA to SLE using FcgRIIB-deficient micePrincipal Investigator
- Principal Investigator
  
  Amano Hirofumi
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Collagenous pathology/Allergology
- Research Institution
  Juntendo University
Role of FcgRIIB for autoantibody production inside and outside of germinal centers
- Principal Investigator
  
  Hirose Sachiko
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Experimental pathology
- Research Institution
  Toin University of Yokohama
Effect of SLAM mutation and activating and inhibitory FcR on autoimmune prone mice
- Principal Investigator
  
  TAKASAKI Yoshinari
- Project Period (FY)
  2014 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Collagenous pathology/Allergology
- Research Institution
  Juntendo University
Genotype identification of RA and SLE using Fc gamma RIIB-deficient B6 mice.Principal Investigator
- Principal Investigator
  
  Amano Hirofumi
- Project Period (FY)
  2013 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Collagenous pathology/Allergology
- Research Institution
  Juntendo University
Epistatic interaction of FcgammaRIIB and Sle16 polymorphism in rheumatoid arthritis
- Principal Investigator
  
  HIROSE Sachiko
- Project Period (FY)
  2012 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Experimental pathology
- Research Institution
  Juntendo University
Immunological disorder via Toll like receptors expressed by sex chromosome in systemic lupus erythematosusPrincipal Investigator
- Principal Investigator
  
  AMANO Hirofumi
- Project Period (FY)
  2009 – 2011
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  膠原病・アレルギー・感染症内科学
- Research Institution
  Juntendo University
Defect of Marginal Zone B cell in Yaa Associated Lupus Prone-micePrincipal Investigator
- Principal Investigator
  
  AMANO Hirofumi
- Project Period (FY)
  2007 – 2008
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  膠原病・アレルギー・感染症内科学
- Research Institution
  Juntendo University
SLEモデルマウスにおけるYaa遺伝子変異によるマージナルゾーンB細胞の分化異常Principal Investigator
- Principal Investigator
  
  天野浩文
- Project Period (FY)
  2005 – 2006
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  膠原病・アレルギー・感染症内科学
- Research Institution
  Juntendo University

[Book] リウマチ病学テキスト（改訂第3版）2022
- Author(s)
  日本リウマチ財団教育研修委員会、日本リウマチ学会生涯教育委員会（天野浩文）
- Total Pages
  608
- Publisher
  南江堂
- ISBN
  9784524231584
- Data Source
  KAKENHI-PROJECT-19K08892
[Book] 膠原病に伴う間質性肺疾患　診断・治療指針2020「第2章各論4全身性エリテマトーデス」「第5章薬物療法以外1アフェレシス療法」2020
- Author(s)
  天野浩文: 日本呼吸器学会・日本リウマチ学会合同　膠原病に伴う間質性肺疾患診断・治療指針作成委員会編
- Total Pages
  227
- Publisher
  メディカルレビュー社
- ISBN
  9784779223686
- Data Source
  KAKENHI-PROJECT-19K08892
[Book] 今日の治療指針　2019年版［IgG4関連疾患］2019
- Author(s)
  福井次矢、高木誠、小室一成［編集］［IgG4関連疾患］天野浩文
- Publisher
  医学書院
- ISBN
- Data Source
  KAKENHI-PROJECT-19K08892
[Journal Article] Genetic dissection of HLA-DRB1*15:01 and XL9 region variants in Japanese patients with systemic lupus erythematosus: primary role for HLA-DRB1*15:012023
- Author(s)
  Kawasaki Aya、Kusumawati Premita Ari、Kawamura Yuka、Kondo Yuya、Kusaoi Makio、Amano Hirofumi、Kusanagi Yasuyoshi、Itoh Kenji、Fujimoto Takashi、Tamura Naoto、Hashimoto Hiroshi、Matsumoto Isao、Sumida Takayuki、Tsuchiya Naoyuki
- Journal Title
  
  RMD Open
  
  Volume: 9 Issue: 2 Pages: e003214-e003214
- DOI
  10.1136/rmdopen-2023-003214
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K08892, KAKENHI-PROJECT-21K08470
[Journal Article] Clinical and Biomarker Responses to BI 655064, an Antagonistic Anti‐CD40 Antibody, in Patients With Active Lupus Nephritis: A Randomized, Double‐Blind, Placebo‐Controlled, Phase II Trial2023
- Author(s)
  Jayne D, Steffgen J, Romero-Diaz J, Bajema I, Boumpas D, Noppakun K, Amano H, Gomez HM, Satirapoj B, Avihingsanon Y, Chawanasuntorapoj R, Madero M, Naumnik B, Recto R, Fagan N, Revollo I, Wu J, Visvanathan S, Furie R
- Journal Title
  
  Arthritis & Rheumatology
  
  Volume: 75 Issue: 11 Pages: 1983-1993
- DOI
  10.1002/art.42557
- Data Source
  KAKENHI-PROJECT-19K08892
[Journal Article] Branched chain amino acids in the treatment of polymyositis and dermatomyositis: a phase II/III, multi-centre, randomized controlled trial2022
- Author(s)
  Kimura Naoki、Kawahara Takuya、Uemura Yukari、Atsumi Tatsuya、Sumida Takayuki、Mimura Toshihde、Kawaguchi Yasushi、Amano Hirofumi、et al.
- Journal Title
  
  Rheumatology
  
  Volume: 61 Issue: 11 Pages: 4445-4454
- DOI
  10.1093/rheumatology/keac101
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K08892, KAKENHI-PROJECT-21K07326
[Journal Article] Grafting of autologous concentrated bone marrow processed using a point-of-care device for patients with osteonecrosis of the femoral head: A phase 1 feasibility and safety study2022
- Author(s)
  Homma Yasuhiro、Masubuchi Yosuke、Shirogane Yuichi、Amano Hirofumi、Muramoto Yuko、Nagao Masashi、Okuno Ryuji、Baba Tomonori、Yamaji Ken、Tamura Naoto、Kaneko Kazuo、Ishijima Muneaki
- Journal Title
  
  Regenerative Therapy
  
  Volume: 20 Pages: 18-25
- DOI
  10.1016/j.reth.2022.03.002
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K09581, KAKENHI-PROJECT-19K08892, KAKENHI-PROJECT-22K11611
[Journal Article] Combining maintenance therapy with hydroxychloroquine increases LLDAS achievement rates in individuals with stable systemic lupus erythematosus2021
- Author(s)
  Yoshida Mai、Minowa Kentaro、Amano Hirofumi、Asai Yuki、Yamaji Ken、Tamura Naoto
- Journal Title
  
  Lupus
  
  Volume: 30 Issue: 9 Pages: 1378-1384
- DOI
  10.1177/09612033211014272
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K08892
[Journal Article] Anti-TLR7 Antibody Protects Against Lupus Nephritis in NZBWF1 Mice by Targeting B Cells and Patrolling Monocytes2021
- Author(s)
  Murakami Yusuke、Fukui Ryutaro、Tanaka Reika、Motoi Yuji、Kanno Atsuo、Sato Ryota、Yamaguchi Kiyoshi、Amano Hirofumi、Furukawa Yoichi、Suzuki Hitoshi、Suzuki Yusuke、Tamura Naoto、Yamashita Naomi、Miyake Kensuke
- Journal Title
  
  Frontiers in Immunology
  
  Volume: 12 Pages: 0-0
- DOI
  10.3389/fimmu.2021.777197
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K08892, KAKENHI-PROJECT-21K15464, KAKENHI-PROJECT-16H06276, KAKENHI-PROJECT-20K07563
[Journal Article] 2020 guide for the diagnosis and treatment of interstitial lung disease associated with connective tissue disease2021
- Author(s)
  Kondoh Y,Makino S,Ogura T,Suda T,Tomioka H,Amano H（計43名中6番目）
- Journal Title
  
  Respiratory Investigation
  
  Volume: 59 Issue: 6 Pages: 709-740
- DOI
  10.1016/j.resinv.2021.04.011
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K08892
[Journal Article] Critical role for mucosal-associated invariant T cells as regulators and therapeutic targets in systemic lupus erythematosus2019
- Author(s)
  Murayama G, Chiba A, Suzuki H, Nomura A, Mizuno T, Kuga T, Nakamura S, Amano H, Hirose S, Yamaji K, Suzuki Y, Tamura N, Miyake S
- Journal Title
  
  Frontiers in Immunology
  
  Volume: 29 Pages: 2681-2681
- DOI
  10.3389/fimmu.2019.02681
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K08252, KAKENHI-PROJECT-19K08892, KAKENHI-PROJECT-17H04218, KAKENHI-PROJECT-17K09983
[Journal Article] First external validation of sensitivity and specificity of the European League Against Rheumatism (EULAR)/American College of Rheumatology (ACR) classification criteria for idiopathic inflammatory myopathies with a Japanese cohort2019
- Author(s)
  Jinnin Masatoshi、Ohta Akiko、Ishihara Shoichiro、Amano Hirofumi、Atsumi Tatsuya、Fujimoto Manabu、Kanda Takashi、Kawaguchi Yasushi、Kawakami Atsushi、Mimori Akio、Mimori Tsuneyo、Mimura Toshihide、Muro Yoshinao、Sano Hajime、Shimizu Jun、et al.
- Journal Title
  
  Annals of the Rheumatic Diseases
  
  Volume: 79 Issue: 3 Pages: 387-392
- DOI
  10.1136/annrheumdis-2019-215488
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K07542, KAKENHI-PROJECT-18K08307, KAKENHI-PROJECT-19K08892
[Journal Article] A novel pathway of peripheral B cell tolerance breakdown induced by inhibitory IgG Fc receptor IIb-deficient monocytes.2018
- Author(s)
  Lin Q, Ohtsuji M, Amano H, Tsurui H, Tada N, Sato R, Fukuyama H, Nishimura H, Verbeek JS, and Hirose S.
- Journal Title
  
  J. Immunol.
  
  Volume: 印刷中
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K08432
[Journal Article] Splicing variant ofWDFY4augments MDA5 signalling and the risk of clinically amyopathic dermatomyositis2018
- Author(s)
  Kochi Yuta et al.
- Journal Title
  
  Annals of the Rheumatic Diseases
  
  Volume: 77 Issue: 4 Pages: 602-611
- DOI
  10.1136/annrheumdis-2017-212149
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16KT0196, KAKENHI-PROJECT-15H05787, KAKENHI-PROJECT-17K09966, KAKENHI-PROJECT-18K07542, KAKENHI-PROJECT-18K08307, KAKENHI-PROJECT-16H05341, KAKENHI-PROJECT-16K09902, KAKENHI-PROJECT-16K09907, KAKENHI-PROJECT-18H02849
[Journal Article] Anti-CD11b antibody treatment suppresses the osteoclast generation, inflammatory cell infiltration, and autoantibody production in arthritis-prone FcγRIIB-deficient mice.2018
- Author(s)
  Ohtsuji M, Lin Q, Okazaki H, Takahashi K, Amano H, Yagita H, Nishimura H, and Hirose S.
- Journal Title
  
  Arthritis Res. Ther.
  
  Volume: 20:25 Issue: 1 Pages: 1-11
- DOI
  10.1186/s13075-018-1523-1
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15K08432, KAKENHI-PROJECT-16K09907
[Journal Article] FcgRIIB on B cells and myeloid cells modulates B cell activation and autoantibody responses via different but synergistic pathways in Lupus-Prone Yaa mice.2018
- Author(s)
  Qingshum Lin, Mareki Ohtsuji, Hirofumi Amano, Hiromichi Tsurui, Norihiro Tada, Ryota Sato, Hidehiro Fukuyama, Hiroyuki Nishimura, J Sjef Verbeek, Sachiko Hisose
- Journal Title
  
  Journal of Immunology
  
  Volume: 201 Issue: 11 Pages: 3199-3210
- DOI
  10.4049/jimmunol.1701487
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K05691, KAKENHI-PROJECT-16K09907, KAKENHI-PROJECT-26430207
[Journal Article] Outcomes of the Re-classification of WHO Class IV Lupus Nephritis Using the ISN/RPS Classification: a Single Center Retrospective Observational Study from the JUDE Study.2017
- Author(s)
  Miyashita T, Morimoto S, Honda D, Nakano S, Amano H, Osawa I, Yamaji K, Tomino Y, Takasaki Y, Tamura N.
- Journal Title
  
  Juntendo Med J.
  
  Volume: 63 Pages: 362-9
- NAID
  130006219741
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16K09907
[Journal Article] Disease flare patterns and predictors of systemic lupus erythematosus in a monocentric cohort of423 Japanese patients during a long-term follow-up:The JUDE study.2017
- Author(s)
  Minowa K,Amano H,Ando S,Watanabe T,Ogasawara M,Kawano S, Kaneko T,Morimoto S,Yamaji K,Tamura N,Tokano Y,Hashimoto H,Takasaki Y.
- Journal Title
  
  Mod Rheumatol.
  
  Volume: 27 Issue: 1 Pages: 72-76
- DOI
  10.1080/14397595.2016.1192745
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-26461474, KAKENHI-PROJECT-16K09907
[Journal Article] Evaluation of the alternative classification criteria of systemic lupus erythematosus established by Systemic Lupus International Collaborating Clinics (SLICC)2017
- Author(s)
  Oku Kenji、Atsumi Tatsuya、Akiyama Yuji、Amano Hirofumi、Azuma Naoto、Bohgaki Toshiyuki、Asanuma Yu Funakubo、Horita Tetsuya、Hosoya Tadashi、Ichinose Kunihiro、Kato Masaru、Katsumata Yasuhiro、Kawaguchi Yasushi、Kawakami Atsushi、Koga Tomohiro et al
- Journal Title
  
  Modern Rheumatology
  
  Volume: 9 Issue: 4 Pages: 1-7
- DOI
  10.1080/14397595.2017.1385154
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16K09885, KAKENHI-PROJECT-16K09907
[Journal Article] IL-6 signal blockade ameliorates the enhanced osteoclastogenesis and the associated joint destruction in a novel FcγRIIB-deficient rheumatoid arthritis mouse model.2015
- Author(s)
  Ohtsuji M, Lin Q, Nishikawa K, Ohtsuji N, Okazaki H, Tsurui H, Amano H, Shirai T, Nishimoto N, Nishimura H, and Hirose S.
- Journal Title
  
  Mod. Rheumatol.
  
  Volume: 25 Issue: 2 Pages: 270-277
- DOI
  10.3109/14397595.2014.950035
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-24590491, KAKENHI-PROJECT-25330349, KAKENHI-PROJECT-15K08432
[Journal Article] Second-to-fourth Digit Ratio in Systemic Lupus Erythematosus2015
- Author(s)
  Doe K, Nozawa K, Hirai T, Tsushima H, Hayashi E, Hiruma K, Ando S, Nakano S, Kon T, Amano H, Yamaji K, Tamura N, Takasaki Y
- Journal Title
  
  J Rheumatol
  
  Volume: 42 Issue: 5 Pages: 826-8
- DOI
  10.3899/jrheum.140974
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-26461474, KAKENHI-PROJECT-25461486
[Journal Article] TNFα but not IL-17 is critical in the pathogenesis of rheumatoid arthritis spontaneously occurring in a unique FcγRIIB-deficient mouse model.2014
- Author(s)
  Okazaki H, Lin Q, Nishikawa K, Ohtsuji N, Tsurui H, Ohtsuji M, Amano H, Tada N, Sudo K, Nishimura H, Shirai T, and Hirose S.
- Journal Title
  
  Mod. Rheumatol.
  
  Volume: 24 Issue: 6 Pages: 931-938
- DOI
  10.3109/14397595.2014.886351
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-24590491, KAKENHI-PROJECT-25330349
[Journal Article] Phenotype conversion from rheumatoid arthritis to systemic lupus erythematosus by introduction of Yaa mutation into FcgRIIB-deficient C57BL/62013
- Author(s)
  Kawano S, Lin Q, Amano H, Kaneko T, Nishikawa K, Tsurui H, Tada N, Nishimura H,Takai T, Shirai T, Takasaki Y and Hirose S
- Journal Title
  
  mice.
  
  Volume: 43 Issue: 3 Pages: 770-778
- DOI
  10.1002/eji.201243057
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590194, KAKENHI-PROJECT-23591450, KAKENHI-PROJECT-24249016, KAKENHI-PROJECT-24590491, KAKENHI-PROJECT-24659215, KAKENHI-PROJECT-25330349, KAKENHI-PROJECT-25461486
[Journal Article] Elevated serum level of circulating syndecan-1(CD138) in active systemic lupus erythematosus2011
- Author(s)
  Minowa K, Amano H, Nakano S, Ando S, Watanabe T, Nakiri Y, Amano E, Tokano Y, Morimoto S, Takasaki Y.
- Journal Title
  
  Autoimmunity
  
  Volume: 44(5) Pages: 357-62
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21591272
[Journal Article] SLEの病態と自然免疫-Toll-like receptorを中心に2011
- Author(s)
  天野浩文
- Journal Title
  
  リウマチ科
  
  Volume: 46(2) Pages: 117-22
- Data Source
  KAKENHI-PROJECT-21591272
[Journal Article] Fcγレセプターと全身性自己免疫疾患2011
- Author(s)
  天野浩文
- Journal Title
  
  日本臨床免疫学会会誌
  
  Volume: 34(1) Pages: 1-7
- NAID
  10029431513
- Data Source
  KAKENHI-PROJECT-21591272
[Journal Article] Up-regulation of the endoplasmic reticulum transmembrane protein UNC93B in the B cells of patients with active systemic lupus erythematosus2010
- Author(s)
  Nakano S, Morimoto S, Suzuki S, Watanabe T, Amano H, Takasaki Y.
- Journal Title
  
  Rheumatology(Oxford)
  
  Volume: 49(5) Pages: 876-81
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21591272
[Journal Article] The association of a nonsynonymous single-nucleotide polymorphism in TNFAIP3 with systemic lupus erythematosus and rheumatoid arthritis in the Japanese population2010
- Author(s)
  Shimane K, Kochi Y, Horita T, Ikari K, Amano H, Hirakata M, Okamoto A, Yamada R, Myouzen K, Suzuki A, Kubo M, Atsumi T, Koike T, Takasaki Y, Momohara S, Yamanaka H, Nakamura Y, Yamamoto K.
- Journal Title
  
  Arthritis Rheum
  
  Volume: 62(2) Pages: 574-9
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21591272
[Journal Article] FTY720 exerts a survival advantage through the prevention of end-stage glomerular inflammation in lupus-prone BXSB mice2010
- Author(s)
  Ando S, Amano H, Amano E, Minowa K, Watanabe T, Nakano S, Nakiri Y, Morimoto S, Tokano Y, Lin Q, Hou R, Ohtsuji M, Tsurui H, Hirose S, Takasaki Y.
- Journal Title
  
  Biochem Biophys Res Commun
  
  Volume: 394(3) Pages: 804-10
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21591272
[Journal Article] Evidence that Yaa-induced loss of marginal zone B cells is a result of dendritic cell-mediated enhanced activation2010
- Author(s)
  Santiago-Raber ML, Amano H, Amano E, Fossati-Jimack L, Swee LK, Rolink A, Izui S.
- Journal Title
  
  J Autoimmun
  
  Volume: 34(4) Pages: 349-55
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21591272
[Journal Article] The long-term prognosis of lupus nephritis patients treated with intravenous cyclophosphamide2010
- Author(s)
  Matsuyama N, Morimoto S, Tokano Y, Amano H, Nozawa K, Isonuma H, Hashimoto H, Takasaki Y.
- Journal Title
  
  Intern Med
  
  Volume: 49(9) Pages: 823-8
- NAID
  130000251879
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21591272
[Journal Article] Evidence that Yaa-induced loss of marginal zone B cells is a result of dendritic cell-mediated enhanced activation.2010
- Author(s)
  Santiago-Raber ML, Amano H, Amano E, Fossati-Jimack L, Swee LK, Rolink A, Izui S.
- Journal Title
  
  J Autoimmun.
  
  Volume: 34 Pages: 349-355
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21591272
[Journal Article] Inhibitory IgG Fc receptor promoter region polymorphism is a key genetic element for murine systemic lupus erythematosus2010
- Author(s)
  Lin Q, Hou R, Sato A, Ohtsuji M, Ohtsuji N, Nishikawa K, Tsurui H, Amano H, Amano E, Sudo K, Nishimura H, Shirai T, Hirose S.
- Journal Title
  
  Autoimmunity
  
  Volume: 34(4) Pages: 356-63
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21591272
[Journal Article] SLEの疾患活動性の評価法と問題点-SLEDAI(original, SLEDAI-2K)とBILAG(classicと2004など)2010
- Author(s)
  天野浩文
- Journal Title
  
  リウマチ科
  
  Volume: 43(6) Pages: 585-592
- Data Source
  KAKENHI-PROJECT-21591272
[Journal Article] FTY720 exerts a survival advantage through the prevention of end-stage glomerular inflammation in Lupus-prone BXSB mice.2010
- Author(s)
  Ando S, Amano H, Amano E, Minowa K, Watanabe T, Nakano S, Nakiri Y, Morimoto S, Tokano Y, Lin Q, Hou R, Ohtsuji M, Tsurui H, Hirose S, Takasaki Y.
- Journal Title
  
  Biochem Biophys Res Commun.
  
  Volume: 394 Pages: 804-810
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21591272
[Journal Article] Up-regulation of the endoplasmic reticulum transmembrane protein UNC93B in the B cells of patients with active systemic lupus erythematosus2010
- Author(s)
  Nakano S, Morimoto S, Suzuki S, Watanabe T, Amano H, Takasaki Y.
- Journal Title
  
  Rheumatology(Oxford) (In print)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21591272
[Journal Article] Inhibitory IgG Fc receptor promoter region polymorphism is a key genetic element for murine systemic lupus erythematosus.2010
- Author(s)
  Lin Q, Hou R, Sato A, Ohtsuji M, Ohtsuji N, Nishikawa K, Tsurui H, Amano H, Amano E, Sudo K, Nishimura H, Shirai T, Hirose S.
- Journal Title
  
  Autoimmunity
  
  Volume: 34 Pages: 356-63
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21591272
[Journal Article] SLEモデルマウスとYaa遺伝子2009
- Author(s)
  天野浩文
- Journal Title
  
  リウマチ科
  
  Volume: 42(2) Pages: 198-204
- Data Source
  KAKENHI-PROJECT-21591272
[Journal Article] Fcgamma receptor-dependent expansion of a hyperactive monocyte subset in lupus-prone mice2009
- Author(s)
  Santiago-Raber ML, Amano H, Amano E, Baudino L, Otani M, Lin Q, Nimmerjahn F, Verbeek JS, Ravetch JV, Takasaki Y, Hirose S, Izui S
- Journal Title
  
  Arthritis and Rheumatism 60(8)
  
  Pages: 2408-2417
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21591272
[Journal Article] Fcgamma receptor-dependent expansion of a hyperactive monocyte subset in lupus-prone mice2009
- Author(s)
  Santiago-Raber ML, Amano H(equal contributor), Amano E, Baudino L, Otani M, Lin Q, Nimmerjahn F, Verbeek JS, Ravetch JV, Takasaki Y, Hirose S, Izui S
- Journal Title
  
  Arthritis Rheum
  
  Volume: 60(8) Pages: 2408-17
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21591272
[Journal Article] Inhibitory IgG Fc receptor promoter region polymorphism is a key genetic element for murine systemic lupus erythematosus2009
- Author(s)
  Lin Q, Hou R, Sato A, Ohtsuji M, Ohtsuji N, Nishikawa K, Tsurui H, Amano H, Amano E, Sudo K, Nishimura H, Shirai T, Hirose S.
- Journal Title
  
  Journal of Autoimmunity (In print)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21591272
[Journal Article] Striking alteration of some populations of T/B cells in systemic lupus erythematosus : relationship to expression of CD62L or some chemokine receptors.2008
- Author(s)
  Watanabe T, Suzuki J, Mitsuo A, Nakano S, Tamayama Y, Katagiri A, Amano H. Morimoto S, Tokano Y, Takasaki Y.
- Journal Title
  
  Lupus 17(1)
  
  Pages: 26-33
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19591180
[Journal Article] Hypocomplementemic Urticarial Vasculitis with Jaccoud's Arthropathy and Valvular Heart Disease (case report and review of the literature)2008
- Author(s)
  Amano H, Furuhata N, Tamura N, Tokano Y, Takasaki Y
- Journal Title
  
  Lupus 17(9)
  
  Pages: 837-41
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19591180
[Journal Article] Striking alteration of some populations of T/B cells in systemic lupus erythematosus : relationship to expression of CD62L or some chemokine receptors2008
- Author(s)
  Watanabe T, Suzuki J, Mitsuo A, Nakano S, Tamayama Y, Katagiri A, Amano H, Morimoto S, Tokano Y, Takasaki Y
- Journal Title
  
  Lupus 17(1)
  
  Pages: 26-33
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19591180
[Journal Article] Hypocomplementemic Urticarial Vasculitis with Jaccoud's Arthropathy and Valvular Heart Disease (case report and review of the literature)2008
- Author(s)
  Amano H, Furuhata N, Tamura N, Tokano Y, Takasaki Y.
- Journal Title
  
  Lupus 17(9)
  
  Pages: 837-841
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19591180
[Journal Article] Role of pathogenic auto-antibody production by Toll-like receptor 9 of B cells in active systemic lupus erythematosus2008
- Author(s)
  Nakano S, Morimoto S, Suzuki J, Nozawa K, Amano H, Tokano Y, Takasaki Y
- Journal Title
  
  Rheumatology (Oxford) 47(2)
  
  Pages: 145-9
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19591180
[Journal Article] Role of pathogenic auto-antibody production by Toll-like receptor 9 of B cells in active systemic lupus erythematosus.2008
- Author(s)
  Nakano S, Morimoto S, Suzuki J, Nozawa K, Amano H, Tokano Y, Takasaki Y.
- Journal Title
  
  Rheumatology (Oxford) 47(2)
  
  Pages: 145-149
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19591180
[Journal Article] Decrease in CD4(+)CD25 (+) and CD8 (+)CD28 (+) T cells in interstitial pneumonitis associated with rheumatic disease2008
- Author(s)
  Katagiri A, Morimoto S, Nakiri Y, Nakano S, Mitsuo A, Suzuki J, Amano H, Nozawa K, Asano M, Tokano Y, Hashimoto H, Takasaki Y
- Journal Title
  
  Mod Rheumatol 18(6)
  
  Pages: 562-9
- NAID
  10025111494
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19591180
[Journal Article] Down-regulation of CD72 and increased surface IgG on B cells in patients with lupus nephritis2007
- Author(s)
  Nakano S, Morimoto S, Suzuki J, Mitsuo A, Nakiri Y, Katagiri A, Nozawa K, Amano H, Tokano Y, Hashimoto H, Takasaki Y
- Journal Title
  
  Autoimmunity 40(1)
  
  Pages: 9-15
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19591180
[Journal Article] Expression of B-cell activating factor of the tumour necrosis factor family (BAFF) in T cells in active systemic lupus erythematosus2007
- Author(s)
  Morimoto S, Nakano S, Watanabe T, Tamayama Y, Mitsuo A, Nakiri Y, Suzuki J, Nozawa K, Amano H, Tokano Y, Kobata T, Takasaki Y
- Journal Title
  
  the role of BAFF in T cell-dependent B cell pathogenic autoantibody production Rheumatology 46(7)
  
  Pages: 1083-6
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19591180
[Journal Article] Expression of CD22 on peripheral B cells in patients with rheumatoid arthritis : relation to CD5-positive B cells2007
- Author(s)
  Nakiri Y, Minowa K, Suzuki J, Mitsuo A, Amano H, Morimoto S, Tokano Y, Takasaki Y
- Journal Title
  
  Clin Rheumatol 26(10)
  
  Pages: 1721-3
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19591180
[Journal Article] 全身性エリテマトーデス(SLE)モデルマウスにおける末梢血の単球増加のメカニズムと病態形成との関わり2006
- Author(s)
  天野浩文
- Journal Title
  
  順天堂医学 52
  
  Pages: 368-375
- NAID
  110006407623
- Data Source
  KAKENHI-PROJECT-17790676
[Journal Article] Genetic dissection of the effects of stimulatory and inhibitory IgG Fc receptors on murine lupus.2006
- Author(s)
  Lin Q, Xiu Y, Jiang Y, Tsurui H, Nakamura K, Kodera S, Ohtsuji M, Ohtsuji N, Shiroiwa W, Tsukamoto K, Amano H, Amano E, Kinoshita K, Sudo K, Nishimura H, Izui S, Shirai T, Hirose S
- Journal Title
  
  J Immunol 1;177(3)
  
  Pages: 1646-1654
- Data Source
  KAKENHI-PROJECT-17790676
[Journal Article] Contribution of Nba2 to Yaa-induced monocytosis in association with murine systemic lupus.2006
- Author(s)
  Kikuchi S, Santiago-Raber ML, Amano H, Amano E, Fossati-Jimack L, Moll T, Kotzin BL, Izui S.
- Journal Title
  
  J Immunol 1;176(5)
  
  Pages: 3240-3247
- Data Source
  KAKENHI-PROJECT-17790676
[Journal Article] CD19/22 balance relates to improvement of disease activity in systemic lupus erythematosus.2006
- Author(s)
  Suzuki J, Nakano S, Nakairi Y, Mitsuo A, Amano H, Morimoto S, Tokano Y, Takasaki Y.
- Journal Title
  
  Mod Rheumatol 16(4)
  
  Pages: 235-238
- NAID
  10019286992
- Data Source
  KAKENHI-PROJECT-17790676
[Presentation] 混合性結合組織病に過敏性肺炎を繰り返し併発した一症例2023
- Author(s)
  中川英美, 山路悠, 今高之, 天野浩文
- Organizer
  第67回日本リウマチ学会総会
- Data Source
  KAKENHI-PROJECT-19K08892
[Presentation] 全身性エリテマトーデスの治療実態と変遷に関する後ろ向き観察研究2023
- Author(s)
  柳本悠佑, 箕輪健太郎, 吉田栄太郎, 浅沼優子, 西卓也, 牧山彩子, 草生真規雄, 松下雅和, 天野浩文, 山路健, 田村直人
- Organizer
  第67回日本リウマチ学会総会
- Data Source
  KAKENHI-PROJECT-19K08892
[Presentation] 統合失調症で加療中, 肺アスペルギルス症と意識障害で顕在化した全身性エリテマトーデスの一例2023
- Author(s)
  今高之, 中川英美, 山路悠, 天野浩文
- Organizer
  第67回日本リウマチ学会総会
- Data Source
  KAKENHI-PROJECT-19K08892
[Presentation] カンジダ血症に伴って多発する静脈血栓症を認めた顕微鏡的多発血管炎の一例2023
- Author(s)
  山路悠, 中川英美, 今高之, 天野浩文
- Organizer
  第67回日本リウマチ学会総会
- Data Source
  KAKENHI-PROJECT-19K08892
[Presentation] 心臓血管手術が施行されたRAとSLE患者の臨床的特徴および免疫組織学的解析2023
- Author(s)
  河本敏雄, 天野浩文, 松下　訓, 箕輪健太郎, 松下雅和, 山路健, 田村直人
- Organizer
  第67回日本リウマチ学会総会
- Data Source
  KAKENHI-PROJECT-19K08892
[Presentation] 心臓疾患を合併するSLE患者とRA患者の臨床的、病理組織学的解析2023
- Author(s)
  河本敏雄, 天野浩文, 松下　訓, 箕輪健太郎, 松下雅和, 山路健, 田村直人
- Organizer
  第51回日本臨床免疫学会総会
- Data Source
  KAKENHI-PROJECT-19K08892
[Presentation] 気管支喘息と血管炎治療の両立が困難であったEGPA症例2022
- Author(s)
  萩原通友, 今高之, 佐伯志津香, 天野浩文
- Organizer
  日本リウマチ学会総会・学術集会
- Data Source
  KAKENHI-PROJECT-19K08892
[Presentation] 当院において心臓手術を施行したSLE患者の特徴と病態解析2022
- Author(s)
  河本敏雄, 天野浩文, 松下　訓, 箕輪健太郎, 村山　豪, 草生真規雄, 松下雅和, 山路健, 田村直人
- Organizer
  日本リウマチ学会総会・学術集会
- Data Source
  KAKENHI-PROJECT-19K08892
[Presentation] 日本人集団におけるXL9領域バリアントおよびHLA-DRB1*15:01と全身性エリテマトーデスの関連解析2022
- Author(s)
  川崎綾, 近藤裕也,藤本隆, 松本功, 草生真規雄, 天野浩文, 田村直人, 草薙恭圭, 伊藤健司, 住田孝之, 土屋尚之
- Organizer
  日本リウマチ学会総会・学術集会
- Data Source
  KAKENHI-PROJECT-19K08892
[Presentation] 血清反応陰性全身性強皮症の二症例2022
- Author(s)
  今高之, 萩原通友, 佐伯志津香, 天野浩文
- Organizer
  日本リウマチ学会総会・学術集会
- Data Source
  KAKENHI-PROJECT-19K08892
[Presentation] 本人集団におけるXL9領域バリアントおよびHLA-DRB1*15:01と全身性エリテマトーデスの関連解析.2022
- Author(s)
  川崎綾, 近藤裕也,藤本隆, 松本功, 草生真規雄, 天野浩文, 田村直人, 草薙恭圭, 伊藤健司, 住田孝之, 土屋尚之
- Organizer
  第66回日本リウマチ学会総会・学術集会
- Data Source
  KAKENHI-PROJECT-19K08892
[Presentation] Clinical Analysis of 34 cases of Cardiac Complications Requiring Surgical Intervention in Systemic Lupus Erythematosus and Assessment about Mechanism of Development with immunological Analysis.2022
- Author(s)
  Toshio Kawamoto, Hirofumi Amano, Satoshi Matsushita, Kentaro Minowa, Masakazu Matsushita, Ken Yamaji, Atsushi Amano, Naoto Tamura
- Organizer
  The Annual European Congress of Rheumatology(EULAR) Copenhagen, Denmark
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K08892
[Presentation] 全身性エリテマトーデス患者における生活の質,骨密度, 睡眠時間に関する検討:順天堂SLE前向きレジストリ研究(JUMP study)より2022
- Author(s)
  松下雅和, 小笠原倫大, 多田久里守, 草生真規雄, 箕輪健太郎, 安倍能之, 天野浩文, 塚原隆伊, 森本真司,　野澤和久, 松平蘭, 片桐彰, 山路健, 田村直人
- Organizer
  日本リウマチ学会総会・学術集会
- Data Source
  KAKENHI-PROJECT-19K08892
[Presentation] 当院でSLEに心臓疾患手術を要した症例の臨床及び病理組織学的な検討-関節リウマチ症例との比較を含めて2022
- Author(s)
  河本敏雄, 天野浩文, 松下　訓, 箕輪健太郎, 松下雅和, 山路健, 田村直人
- Organizer
  日本臨床免疫学会総会・学術集会
- Data Source
  KAKENHI-PROJECT-19K08892
[Presentation] 維持期全身性エリテマトーデス患者へのヒドロキシクロロキン2年間の追加投与効果2020
- Author(s)
  吉田舞, 箕輪健太郎, 天野浩文, 浅井悠貴, 山路健, 田村直人
- Organizer
  第64回日本リウマチ学会総会・学術集会
- Data Source
  KAKENHI-PROJECT-19K08892
[Presentation] 全身性エリテマトーデスの病態におけるTLR7の役割についての検討2020
- Author(s)
  村上祐輔, 福井竜太郎, 天野浩文, 鈴木仁, 本井祐二, 田村直人, 三宅健介
- Organizer
  第64回日本リウマチ学会総会・学術集会
- Data Source
  KAKENHI-PROJECT-19K08892
[Presentation] 当院において心臓手術を施行したSLE患者の特徴と病態解析2020
- Author(s)
  河本敏雄, 天野浩文, 吉田舞, 箕輪健太郎, 松下雅和, 山路健, 田村直人
- Organizer
  第64回日本リウマチ学会総会・学術集会
- Data Source
  KAKENHI-PROJECT-19K08892
[Presentation] ベリムマブ導入により抗DNA抗体価が陰転化していたが、TMAで再燃した全身性エリテマトーデスの一例2020
- Author(s)
  箕輪健太郎, 天野浩文, 富田裕之, 宮下知子, 安倍能之, 多田久里守, 山路健, 田村直人
- Organizer
  第64回日本リウマチ学会総会・学術集会
- Data Source
  KAKENHI-PROJECT-19K08892
[Presentation] SLEに併発した心臓疾患で手術を要した30例に於ける臨床的特徴と発症機序の考察2020
- Author(s)
  河本敏雄, 天野浩文, 松下訓, 箕輪健太郎, 山路健, 田村直人
- Organizer
  第48回日本臨床免疫学会総会
- Data Source
  KAKENHI-PROJECT-19K08892
[Presentation] Monocyteの活性化と自己免疫疾患2020
- Author(s)
  大辻希樹, 天野浩文, 岡崎英規, 西村裕之, 広瀬幸子
- Organizer
  第64回日本リウマチ学会総会・学術集会
- Data Source
  KAKENHI-PROJECT-19K08892
[Presentation] 全身性エリテマトーデス患者におけるループス低疾患活動状態の達成と生活の質に関する検討：順天堂SLE前向きレジストリ研究（JUMP study）より2020
- Author(s)
  松下雅和, 天野浩文, 野澤和久, 小笠原倫大, 多田久里守, 建部一夫, 草生真規雄, 河本敏雄, 箕輪健太郎, 安藤誠一郎, 根本卓也, 安倍能之, 林絵利, 村山豪, 塚原隆伊, 山中健次郎, 梁広石, 松平蘭, 片桐彰, 名切裕, 髙崎芳成, 山路健, 田村直人
- Organizer
  第64回日本リウマチ学会総会・学術集会
- Data Source
  KAKENHI-PROJECT-19K08892
[Presentation] A study on the achievement of lupus low disease activity state and quality of life in patients with systemic lupus erythematosus: From the Juntendo University SLE prospective restry study.2020
- Author(s)
  Matsushita-M , Amano-H , Nozawa-K, Ogasawara-M, Tada-K, Kazuo-K, Kusaoi-M, Kawamoto-T, Minowa-K, Ando-S, Nemoto-T, Abe-Y, Hayashi-E, Murayama-G, Tsukahara-Y, Yamanaka-K, Morimoto-S, Yang-K, Matsudaira-R, Katagiri-A, Nakiri-Y, Takasaki-Y, Yamaji-K, Tamura-N
- Organizer
  The Annual European Congress of Rheumatology(EULAR)
- Data Source
  KAKENHI-PROJECT-19K08892
[Presentation] MAIT細胞-全身性エリテマトーデスの新規治療ターゲット2019
- Author(s)
  村山豪, 千葉麻子, 天野浩文, 山路健, 田村直人, 三宅幸子.
- Organizer
  第63回日本リウマチ学会総会・学術集会.2019.4-15-17
- Data Source
  KAKENHI-PROJECT-19K08892
[Presentation] 抗CD11b抗体投与によるFcγRIIB欠損マウスに自然発症する関節炎の抑制効果.2019
- Author(s)
  大辻希樹, 天野浩文, 岡崎英規, 西村裕之, 広瀬幸子.
- Organizer
  第63回日本リウマチ学会総会・学術集会.2019.4-15-17
- Data Source
  KAKENHI-PROJECT-19K08892
[Presentation] シェーグレン症候群の長期経過中に肺高血圧症を続発し,ステロイドに対する反応性が良好であった一例.2019
- Author(s)
  135.小山真由子, 松下雅和, 久我大雅, 安藤誠一郎, 今高之, 多田久里守, 天野浩文, 山路健, 田村直人.
- Organizer
  第63回日本リウマチ学会総会・学術集会.2019.4-15-17
- Data Source
  KAKENHI-PROJECT-19K08892
[Presentation] SLE患者における抗U1-RNP抗体,抗Sm抗体の陽転化についての解析.2019
- Author(s)
  箕輪健太郎, 天野浩文, 浅井悠貴, 吉田舞, 河野晋也, 安藤誠一郎, 山路健, 田村直人.
- Organizer
  第63回日本リウマチ学会総会・学術集会.2019.4-15-17
- Data Source
  KAKENHI-PROJECT-19K08892
[Presentation] MAIT cells enhance autoreactive B cell responses in a murine model of lupus.2019
- Author(s)
  Taiga Kuga, Gou Murayama, Asako Chiba, Tomohiro Mizuno, Atsushi Nomura, Hirofumi Amano, Sachiko Hirose, Ken Yamaji, Naoto Tamura, Sachiko Miyake.
- Organizer
  第48回日本免疫学会学術集会.2019.12.11-13
- Data Source
  KAKENHI-PROJECT-19K08892
[Presentation] 全身性エリテマトーデスにおける不可逆的腎不全患者の臨床的特徴2019
- Author(s)
  吉田舞, 箕輪健太郎, 天野浩文, 山路健, 田村直人.
- Organizer
  第47回日本臨床免疫学会 2019.10.17-19
- Data Source
  KAKENHI-PROJECT-19K08892
[Presentation] SLEに併発した心臓疾患で手術を要した30例の解析.2019
- Author(s)
  河本敏雄, 天野浩文, 松下訓, 箕輪健太郎, 吉田舞, 山路健, 天野篤, 田村直人
- Organizer
  第47回日本臨床免疫学会 2019.10.17-19
- Data Source
  KAKENHI-PROJECT-19K08892
[Presentation] Contribution of monocyte subsets in autoimmune diseases.2019
- Author(s)
  Mareki Ohtsuji, Qingshun Lin, Hidehiro Fukuyama, Hirofumi Amano, Hiroyuki Nishimura, J Sjef Verbeek, Sachiko Hirose.
- Organizer
  第48回日本免疫学会学術集会.2019.12.11-13
- Data Source
  KAKENHI-PROJECT-19K08892
[Presentation] Mucosal-associated Invariant T Cells Can Be Therapeutically Targeted in Lupus.2019
- Author(s)
  Goh Murayama, Asako Chiba, Tomohiro Mizuno, Atsushi Nomura, Taiga Kuga, Hirofumi Amano, Ken Yamaji, Naoto Tamura, Sachiko Miyake.
- Organizer
  85th Annual Scientific Meeting of American College of Rheumatology, Atlanta, Georgia, Norvember8-13, 2019
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K08892
[Presentation] 心臓血管手術を要したSLE患者における弁膜症,虚血性心疾患,大動脈瘤の特徴とその比較について2019
- Author(s)
  136.河本敏雄, 天野浩文, 箕輪健太郎, 吉田舞, 浅井悠貴, 山路健, 田村直人.
- Organizer
  第63回日本リウマチ学会総会・学術集会.2019.4-15-17
- Data Source
  KAKENHI-PROJECT-19K08892
[Presentation] 全身性エリテマトーデス患者における不可逆的腎不全患者の検討.2019
- Author(s)
  吉田舞, 箕輪健太郎, 天野浩文, 山路健, 田村直人.
- Organizer
  第63回日本リウマチ学会総会・学術集会.2019.4-15-17
- Data Source
  KAKENHI-PROJECT-19K08892
[Presentation] Treatment with anti-CD11b antibody ameliorates arthritis in a novel arthritis-prone mouse model2018
- Author(s)
  Mareki Ohtsuji, Qingshun Lin, Hirofumi Amano, Hideo Yagita, Kazuko Takahashi, Hideki Okazaki, Hiroyuki Nishimura, Sachiko Hirose.
- Organizer
  The 47th Annual Meeting of the Japanese Society for Immunology
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K09907
[Presentation] ループスモデルにおけるMAT細胞に関する解析CD11b陽性細胞の機能抑制による関節炎自然発症モデルマウスの病態抑制効果.2018
- Author(s)
  村山豪,千葉麻子,天野浩文,山路健,田村直人,三宅幸子.
- Organizer
  日本リウマチ学会総会・学術集会
- Data Source
  KAKENHI-PROJECT-16K09907
[Presentation] CD11b陽性細胞の機能抑制による関節炎自然発症モデルマウスの病態抑制効果.2018
- Author(s)
  大辻希樹, 林青順, 天野浩文,岡崎英規, 西村裕之,広瀬幸子.
- Organizer
  日本リウマチ学会総会・学術集会
- Data Source
  KAKENHI-PROJECT-16K09907
[Presentation] 日本人集団における全身性エリテマトーデスおよび全身性強皮症とGTF21遺伝子多型との関連2018
- Author(s)
  横山望,川崎綾,松下貴史,古川宏,近藤裕也,松本功,草生真規雄,天野浩文,長岡章平,瀬戸口京吾,永井立夫,島田浩太,杉井章二,岡本亨,千葉実行,末松栄一,大野滋,片山雅夫,右田清志,河野肇,長谷川稔,藤本学,田村直人,髙崎芳成,橋本博史,佐藤伸一,住田孝之,當間重人,竹原和彦,土屋尚之
- Organizer
  日本リウマチ学会総会・学術集会
- Data Source
  KAKENHI-PROJECT-16K09907
[Presentation] 全身性エリテマトーデス2018
- Author(s)
  天野浩文
- Organizer
  第33回臨床リウマチ学会スポンサードシンポジウム
- Data Source
  KAKENHI-PROJECT-16K09907
[Presentation] MAIT cells as a new therapeutic target for systemic lupus erythematosus.2018
- Author(s)
  Asako Chiba, Goh Murayama, Tomohiro Mizuno, Hirofumi Amono, Sachiko Hirose, Ken Yamaji, Naoto Tamura, Sachiko Miyake.
- Organizer
  The 47th Annual Meeting of the Japanese Society for Immunology
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K09907
[Presentation] 全身性エリテマトーデス患者における酸化ストレスと抗酸化力の解析2018
- Author(s)
  浅井悠貴,安藤誠一郎,天野浩文,山路健,田村直人.
- Organizer
  日本リウマチ学会総会・学術集会
- Data Source
  KAKENHI-PROJECT-16K09907
[Presentation] 全身性エリテマトーデスに合併した心疾患で手術が施行された35症例の検討.2018
- Author(s)
  河本敏雄, 天野浩文, 松下訓, 箕輪健太郎, 浅井悠貴, 山路健, 天野篤, 田村直人.
- Organizer
  第46回日本臨床免疫学会総会.
- Data Source
  KAKENHI-PROJECT-16K09907
[Presentation] 安定期SLE患者へのヒドロキシクロロキン追加投与効果.2018
- Author(s)
  箕輪健太郎,天野浩文,浅井悠貴,河野晋也,山路健,田村直人.
- Organizer
  日本リウマチ学会総会・学術集会
- Data Source
  KAKENHI-PROJECT-16K09907
[Presentation] Slam遺伝子異常マウスにおける末梢血中の単球増加とYaa遺伝子変異による自己免疫疾患の病態変化2017
- Author(s)
  天野浩文, 西川桂子, 小城敬, 林青順, 河野晋也, 山路健, 田村直人,広瀬幸子
- Organizer
  日本リウマチ学会総会・学術集会
- Data Source
  KAKENHI-PROJECT-16K09907
[Presentation] 免疫アレルギー疾患の病態と分子標的療法ー全身性エリテマトーデス2017
- Author(s)
  天野浩文
- Organizer
  日本皮膚アレルギー・接触皮膚炎学会総会学術大会
- Invited
- Data Source
  KAKENHI-PROJECT-16K09907
[Presentation] Lupus-prone SLAM haplotype exerts monocytosis and develops mixed connective tissue disease-like phenotype introduced by Yaa mutation.2017
- Author(s)
  Hirofumi Amano, Keiko Nishikawa, Qingshun Lin, Shinya Kawano, Ken Yamaji, Sachiko Hirose, Naoto Tamura
- Organizer
  APLAR(Asia Pacific League of Associations for Rhematology:アジアリウマチ学会）
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K09907
[Presentation] Slam遺伝子異常マウスにおける末梢血中の単球増加とYaa遺伝子変異による自己免疫疾患の病態変化2017
- Author(s)
  天野浩文、他
- Organizer
  第61回日本リウマチ学会総会・学術集会
- Data Source
  KAKENHI-PROJECT-15K08432
[Presentation] Lupus-prone SLAM haplotype exerts monocytosis and develops specific phenotype of autoimmune disease introduced by Yaa mutation.2017
- Author(s)
  Hirofumi Amano, et al.
- Organizer
  2017 UELAR ヨーロッパリウマチ学会
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K08432
[Presentation] Slam 遺伝子異常マウスにおける末梢血中の単球増加と Yaa 遺伝子変異による自己免疫疾患の病態変化2017
- Author(s)
  天野浩文，西川桂子，林　青順，河野晋也，山路　健，広瀬幸子，田村直人
- Organizer
  日本臨床免疫学会
- Data Source
  KAKENHI-PROJECT-16K09907
[Presentation] Role of Inhibitory IgG Fc Receptor IIB on B cells and monocytes in Yaa-related murine lupus.2017
- Author(s)
  Sachiko Hirose, Qingshun Lin, Mareki Otsuji, Hiroyuki Nishimura, Hirofumi Amano, J.Sjef Verbeek.
- Organizer
  EULAR（The European League Against Rheumatism:ヨーロッパリウマチ学会）
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K09907
[Presentation] Inhibitory IgG Fc receptor IIB on B cells and monocytes independenly controls Yaa-induced murine lupus.2016
- Author(s)
  Lin Q, Tsurui H, Nishikawa K, Amano H, Ohtsuji M, Nishimura H, Verbeek JS, Hirose S.
- Organizer
  第45回日本免疫学会総会・学術集会
- Place of Presentation
  沖縄
- Year and Date
  2016-12-05
- Data Source
  KAKENHI-PROJECT-15K08432
[Presentation] Role of Mucosal-associated Invariant T(MAIT)Cells In Lupus Dermatitis.2016
- Author(s)
  Goh Murayama,Asako Chiba,Hirofumi Amano,Ken Yamaji, Naoto Tamu-ra,Sachiko Miyake.
- Organizer
  第45回日本免疫学会総会・学術集会
- Place of Presentation
  沖縄
- Year and Date
  2016-12-05
- Data Source
  KAKENHI-PROJECT-26461474
[Presentation] 全身性エリテマトーデス患者における酸化ストレスマーカーd-ROMsと抗酸化力BAP2016
- Author(s)
  安藤誠一郎, 天野浩文, 浅井悠貴、山路健, 田村直人, 髙崎芳成
- Organizer
  第60本リウマチ学会総会・学術集会
- Place of Presentation
  横浜
- Year and Date
  2016-04-21
- Data Source
  KAKENHI-PROJECT-16K09907
[Presentation] 全身性エリテマトーデス患者における酸化ストレスマーカーd-ROMsと抗酸化力BAP2016
- Author(s)
  安藤誠一郎,天野浩文,浅井悠貴、山路健, 田村直人, 髙崎芳成
- Organizer
  第60回日本リウマチ学会総会・学術集会
- Place of Presentation
  横浜
- Year and Date
  2016-04-21
- Data Source
  KAKENHI-PROJECT-26461474
[Presentation] Inhibitory IgG Fc Receptor IIB on B cells and monocytes independently controls Yaa-induced murine lupus.2016
- Author(s)
  Qingshun Lin, Hiromichi Tsurui, Hirofumi Amano, Keiko Nishikawa, Mareki Otsuji, Hiroyuki Nishimura, J.Sjef Verbeek, Sachiko Hirose.
- Organizer
  第45回日本免疫学会総会・学術集会
- Place of Presentation
  沖縄
- Year and Date
  2016-12-05
- Data Source
  KAKENHI-PROJECT-16K09907
[Presentation] Blocking of CD11b+cell-migration ameliorates rheumatoid arthritis-like disease spontaneously occurring in a unique FcRIIB-deficient mouse model.2016
- Author(s)
  Mareki Otsuji,Qingshun Lin,Hideki Okazaki,Shuri Ikeda, Hinako Sasa-ki,Hirofumi Amano,Hideo Yagita,Hiroyuki Nishimura,Sachiko Hirose.
- Organizer
  第45回日本免疫学会総会・学術集会
- Place of Presentation
  沖縄
- Year and Date
  2016-12-05
- Data Source
  KAKENHI-PROJECT-26461474
[Presentation] Mechanism for cell type-specific contribution of inhibitory IgG Fc receptor IIB in Yaa-induced murine lupus.2016
- Author(s)
  Hirose S, Lin, Q, Amano H, Nishimura H, Verbeek JS
- Organizer
  10th International Congress on Autoimmunity
- Place of Presentation
  Leipzig, Germany
- Year and Date
  2016-04-06
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K08432
[Presentation] Blocking of CD11b+ cell-migration ameliorates rheumatoid arthritis-like disease spontaneously occurring in a unique FcγRIIB-deficient mouse model.2016
- Author(s)
  Ohtsuji M, Lin Q, Okazaki H, Ikeda S, Sasaki H, Amano H, Yagita H, Nishimura H, Hirose S.
- Organizer
  第45回日本免疫学会総会・学術集会
- Place of Presentation
  沖縄
- Year and Date
  2016-12-05
- Data Source
  KAKENHI-PROJECT-15K08432
[Presentation] Role of Mucosal-associated Invariant T(MAIT) Cells In Lupus Dermatitis.2016
- Author(s)
  120.Goh Murayama, Asako Chiba, Hirofumi Amano, Ken Yamaji, Naoto Tamura, Sachiko Miyake.
- Organizer
  第45回日本免疫学会総会・学術集会
- Place of Presentation
  沖縄
- Year and Date
  2016-12-05
- Data Source
  KAKENHI-PROJECT-16K09907
[Presentation] 日本人全身性エリテマトーデスとHLA-G多型の関連2016
- Author(s)
  川崎綾, 八谷有紀,　古川宏, 近藤裕也, 伊藤聡, 松本功, 草生真規雄, 天野浩文, 須田昭子, 長岡章平, 瀬戸口京吾, 永井立夫, 廣畑俊成, 島田浩太, 杉井章二, 岡本亨, 千葉実行, 末松栄一, 大野滋, 片岡雅夫, 岡本明子, 河野肇, 髙崎芳成, 橋本博史, 住田孝之, 當間重人, 土屋尚之
- Organizer
  第60回日本リウマチ学会総会・学術集会
- Place of Presentation
  横浜
- Year and Date
  2016-04-21
- Data Source
  KAKENHI-PROJECT-16K09907
[Presentation] 日本人全身性エリテマトーデスとHLA-G多型の関連2016
- Author(s)
  川崎綾,八谷有紀, 古川宏,近藤裕也,伊藤聡,松本功,草生真規雄,天野浩文,須田昭子,長岡章平,瀬戸口京吾,永井立夫,廣畑俊成, 島田浩太,杉井章二, 岡本亨, 千葉実行,末松栄一,大野滋,片岡雅夫, 岡本明子,河野肇, 髙崎芳成,橋本博史,住田孝之, 當間重人, 土屋尚之
- Organizer
  第60回日本リウマチ学会総会・学術集会
- Place of Presentation
  横浜
- Year and Date
  2016-04-21
- Data Source
  KAKENHI-PROJECT-26461474
[Presentation] Inhibitory IgG Fc Receptor IIB on B cells and monocytes independently controls Yaa-induced murine lupus.2016
- Author(s)
  Qingshun Lin,Hiromichi Tsurui,Hirofumi Amano,Keiko Nishikawa,Mareki Otsuji,Hiroyuki Nishimura, J.Sjef Verbeek, Sachiko Hirose.
- Organizer
  第45回日本免疫学会総会・学術集会
- Place of Presentation
  沖縄
- Year and Date
  2016-12-05
- Data Source
  KAKENHI-PROJECT-26461474
[Presentation] Blocking of CD11b+ cell-migration ameliorates rheumatoid arthritis-like disease spontaneously occurring in a unique FcRIIB-deficient mouse model.2016
- Author(s)
  Mareki Otsuji, Qingshun Lin, Hideki Okazaki, Shuri Ikeda, Hinako Sasaki, Hirofumi Amano, Hideo Yagita, Hiroyuki Nishimura, Sachiko Hirose.
- Organizer
  第45回日本免疫学会総会・学術集会
- Place of Presentation
  沖縄
- Year and Date
  2016-12-05
- Data Source
  KAKENHI-PROJECT-16K09907
[Presentation] Mechanism of Phenotype Conversion from Rheumatoid Arthritis to Lupus in FcγRIIB-Deficient C57BL/6 .Yaa mice.2015
- Author(s)
  Shinya Kawano, Hirofumi Amano, Qingshun Lin, Keiko Nishikawa, Hiromichi Tsurui, Toshikazu Shirai, Sachiko Hirose, Yoshinari Takasaki.
- Organizer
  EULAR (Annual European Congress of Rheumatology)
- Place of Presentation
  Rome, Italy
- Year and Date
  2015-06-10
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25461486
[Presentation] SLE発症に対するFcγRIIB欠損、Slam多型およびYaa遺伝子の影響2015
- Author(s)
  西川桂子、林　青順、天野浩文、西村裕之、白井俊一、広瀬幸子
- Organizer
  第59回日本リウマチ学会総会・学術集会
- Place of Presentation
  名古屋市、愛知県
- Year and Date
  2015-04-23
- Data Source
  KAKENHI-PROJECT-15K08432
[Presentation] TLR標的ループス治療の理論と障壁. SLEにおける自然免疫2015
- Author(s)
  天野浩文
- Organizer
  日本リウマチ学会総会・学術集会
- Place of Presentation
  名古屋
- Year and Date
  2015-04-23
- Data Source
  KAKENHI-PROJECT-25461486
[Presentation] Dichotomy in FcγRIIb deficiency and autoimmune- prone SLAM haplotype reveals the role of SLAM haplotype in monocytosis and the significant effect of FcγRIIb deficiency in Yaa-related lupus nephritis.2015
- Author(s)
  K. Nishikawa, Q. Lin, H. Tsurui, S. Kawano, K. Kojo, H. Amano, T. Shirai, S. Hirose.
- Organizer
  Annual European Congress of Rheumatology
- Place of Presentation
  Rome, Italy
- Year and Date
  2015-06-10
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K08432
[Presentation] SLE発症に対するFcγRⅡB欠損、Slam多型およびYaa遺伝子の影響2015
- Author(s)
  西川桂子, 林青順, 天野浩文, 西村裕之, 白井俊一, 廣瀬幸子
- Organizer
  日本リウマチ学会総会・学術集会
- Place of Presentation
  名古屋
- Year and Date
  2015-04-23
- Data Source
  KAKENHI-PROJECT-25461486
[Presentation] Disease flare-up patterns and predictors in a long-term follow-up of 423 Japanese SLE patients from the monocentric cohort JUDE study.2015
- Author(s)
  Hirofumi Amano, Seiichiro Ando, Kentaro Minowa, Takashi Watanabe, Michihiro Ogasawara, Shinji Morimoto, Yoshiaki Tokano, Ken Yamaji, Naoto Tamura, Yoshinari Takasaki.
- Organizer
  EULAR (Annual European Congress of Rheumatology)
- Place of Presentation
  Rome, Italy
- Year and Date
  2015-06-10
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25461486
[Presentation] Role of inhibitory FcγRIIb and autoimmune-prone SLAM haplotype in autoimmune disease.2015
- Author(s)
  NISHIKAWA Keiko, LIN Qingshun, TSURUI Hiromichi, AMANO Hirofumi, OKAZAKI Hideki, OHTSUJI Mareki, NISHIMURA Hiroyuki, SHIRAI Toshikazu, HIROSE Sachiko.
- Organizer
  第44回日本免疫学会総会・学術集会
- Place of Presentation
  札幌市、北海道
- Year and Date
  2015-11-18
- Data Source
  KAKENHI-PROJECT-15K08432
[Presentation] 細胞特異的FcγRIIB発現欠損マウス系の樹立によるYaa誘導ループス腎炎発症機序の解明2015
- Author(s)
  林　青順、西川桂子、大辻希樹、天野浩文、西村裕之、白井俊一、広瀬幸子
- Organizer
  第59回日本リウマチ学会総会・学術集会
- Place of Presentation
  名古屋市、愛知県
- Year and Date
  2015-04-23
- Data Source
  KAKENHI-PROJECT-15K08432
[Presentation] LILRA4多型と全身性エリテマトーデスの関連の検討2015
- Author(s)
  川崎綾, 古川宏, 近藤裕也, 伊藤聡, 松本功, 草生真規雄, 天野浩文, 須田昭子, 長岡章平, 瀬戸口京吾, 永井立夫, 廣畑俊成, 島田浩太, 杉井章二, 岡本亨, 千葉実行, 末松栄一, 大野滋, 片岡雅夫, 岡本明子, 河野肇, 髙崎芳成, 橋本博史, 住田孝之, 當間重人, 土屋尚之
- Organizer
  第59回日本リウマチ学会総会・学術集会
- Place of Presentation
  名古屋
- Year and Date
  2015-04-23
- Data Source
  KAKENHI-PROJECT-26461474
[Presentation] 細胞特異的FcγRIIB発現欠損マウス系の樹立によるYaa誘導ループス腎炎発症機序の解明2015
- Author(s)
  林青順, 西川桂子, 大辻希樹, 天野浩文, 西村裕之, 白井俊一, 広瀬幸子
- Organizer
  日本リウマチ学会総会・学術集会
- Place of Presentation
  名古屋
- Year and Date
  2015-04-23
- Data Source
  KAKENHI-PROJECT-25461486
[Presentation] 抗リン脂質抗体がSLEの病型に与える影響について2015
- Author(s)
  山田祐介, 野澤和久, 天野浩文, 関川巌, 髙崎芳成
- Organizer
  第59回日本リウマチ学会総会・学術集会
- Place of Presentation
  名古屋
- Year and Date
  2015-04-23
- Data Source
  KAKENHI-PROJECT-26461474
[Presentation] 関節炎自然発症FcγRIIB欠損マウスにおける抗IL-6R抗体の予防および治療効果の解析2015
- Author(s)
  大辻希樹、林　青順、西川桂子、岡崎英規、天野浩文、西村裕之、西本憲弘、白井俊一、広瀬幸子
- Organizer
  第59回日本リウマチ学会総会・学術集会
- Place of Presentation
  名古屋市、愛知県
- Year and Date
  2015-04-23
- Data Source
  KAKENHI-PROJECT-15K08432
[Presentation] Mechanism of phenotype conversion from rheumatoid arthritis to lupus in FcγRIIB-deficient C57BL/6 Yaa mice2015
- Author(s)
  Kawano S, Amano H, Q.Lin, Nishikawa K, H.T.Tsurui, Shirai T, Hirose S, Takasaki Y
- Organizer
  Annual European Congress of Rheumatology
- Place of Presentation
  ローマ、イタリア
- Year and Date
  2015-06-10
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26461474
[Presentation] Cell type-specific inhibitory IgG Fc receptor IIB in Yaa-induced murine lupus.2015
- Author(s)
  LIN Qingshun, TSURUI Hiromichi, NISHIKAWA Keiko, AMANO Hirofumi, OHTSUJI Mareki, NISHIMURA Hiroyuki, SHIRAI Toshikazu, VERBEEK J. Sjef, HIROSE Sachiko.
- Organizer
  第44回日本免疫学会総会・学術集会
- Place of Presentation
  札幌市、北海道
- Year and Date
  2015-11-18
- Data Source
  KAKENHI-PROJECT-15K08432
[Presentation] 全身性エリテマトーデス患者における腹水貯留に関する検討2015
- Author(s)
  今高之, 塚原隆伊, 安倍俊之, 安藤誠一郎, 多田久里守, 建部一夫, 天野浩文, 山路健, 田村直人, 髙崎芳成
- Organizer
  第59回日本リウマチ学会総会・学術集会
- Place of Presentation
  名古屋
- Year and Date
  2015-04-23
- Data Source
  KAKENHI-PROJECT-26461474
[Presentation] 劇症型A群連鎖球菌による蜂窩織炎を発症した結節性多発動脈炎の一例2015
- Author(s)
  塚原隆伊, 多田久里守, 天野浩文, 山路健, 田村直人, 髙崎芳成
- Organizer
  第59回日本リウマチ学会総会・学術集会
- Place of Presentation
  名古屋
- Year and Date
  2015-04-23
- Data Source
  KAKENHI-PROJECT-26461474
[Presentation] 膠原病治療 Update：BIOLOGICSを中心に-全身性エリテマトーデス-.2015
- Author(s)
  天野浩文
- Organizer
  日本臨床リウマチ学会
- Place of Presentation
  神戸
- Year and Date
  2015-11-22
- Invited
- Data Source
  KAKENHI-PROJECT-25461486
[Presentation] Mechanism of phenotype conversion from rheumatoid arthritis to lupus in FcγRIIB-deficient C57BL/6 Yaa mice.2015
- Author(s)
  S. Kawano, H. Amano, Q. Lin, K. Nishikawa, H.T. Tsurui, T. Shirai, S. Hirose, Y. Takasaki.
- Organizer
  Annual European Congress of Rheumatology
- Place of Presentation
  Rome, Italy
- Year and Date
  2015-06-10
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K08432
[Presentation] Phenotype conversion from rheumatoid arthritis to systemic lupus erythematosus by introduction of Yaa mutation into FcγRIIB-deficient C57BL/6 mice2014
- Author(s)
  Shinya Kawano, Qingshun Lin, Hirofumi Amano, Toshiyuki Kaneko, Keiko Nishikawa, Hiromichi Tsurui, Norihiro Tada, Hiroyuki Nishimura, Toshiyuki Takai, Shirai Toshikazu, Sachiko Hirose, Yoshinari Takasaki
- Organizer
  日本リウマチ学会総会・学術集会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-25461486
[Presentation] Phenotype conversion from rheumatoid arthritis to systemic lupus erythematosus by introduction of Yaa mutation into FcgRIIB-deficient C57BL/6 mice.2013
- Author(s)
  (Oral) Sachiko Hirose, Shinya Kawano, Qingshun Lin, Hirofumi Amano, Toshiyuki Kaneko, Keiko Nishikawa, Hiromichi Tsurui, Hiroyuki Nishimura, Toshikazu Shirai.
- Organizer
  15th International Congress of Immunology,
- Place of Presentation
  Milan, Italy
- Data Source
  KAKENHI-PROJECT-24590491
[Presentation] B cell specific deficiency of FcgRIIB results in high levels of autoantibodies without severe lupus nephritis in C57BL/6.Yaa mice.2013
- Author(s)
  (口頭) LIN Qingshun, NISHIKAWA Keiko, TSURUI Hiromichi, OKAZAKI Hideki, OHTSUJI Mareki, NISHIMURA Hiroyuki, AMANO Hirofumi, SHIRAI Toshikazu, HIROSE Sachiko.
- Organizer
  第42回日本免疫学会総会・学術集会
- Place of Presentation
  幕張
- Data Source
  KAKENHI-PROJECT-24590491
[Presentation] Phenotype conversion from rheumatoid arthritis to systemic lupus erythematosus by introduction of Yaa mutation into FcγRIIB-deficient C57BL/6 mice.2013
- Author(s)
  Shinya Kawano, Toshiyuki Kaneko, Aya Sato- Hayashizaki, Lin Qingshun, Hirofumi Amano. Sachiko Hirose, Yoshinari Takasaki.
- Organizer
  5th East Asian Group of Rheumatology.
- Place of Presentation
  ソウル、韓国
- Data Source
  KAKENHI-PROJECT-24590491
[Presentation] FcγレセプターIIB欠損マウスを用いたRAとSLEの特異性を決める遺伝的要因の解析2013
- Author(s)
  天野浩文, 金子俊之, 河野晋也, 林青順, 西川桂子, 鶴井博理, 大辻希樹, 西村裕之, 広瀬幸子, 髙崎芳成
- Organizer
  第41回日本臨床免疫学会総会
- Place of Presentation
  下関
- Data Source
  KAKENHI-PROJECT-25461486
[Presentation] Clarification of　the　role　of　FcgRIIB　for　autoimmune　disease using　the　cell-specific　FcgRIIB　conditional knockout　mice.2013
- Author(s)
  Qingshun Lin, Hirofumi Amano, Hiroyuki Nishimura, Keiko Nishikawa, Sachiko Hirose.
- Organizer
  第57回日本リウマチ学会総会・学術集会
- Place of Presentation
  京都
- Data Source
  KAKENHI-PROJECT-24590491
[Presentation] Clarification of the role of FcgRIIB for autoimmune disease using the cellspecific FcgRIIB conditionalkanockout mice2013
- Author(s)
  Qingshun Lin, Hirofumi Amano, Hiroyuki Nishimura, Keiko Nishikawa, Sachiko Hirose
- Organizer
  第57回日本リウマチ学会総会・学術集会
- Place of Presentation
  京都
- Data Source
  KAKENHI-PROJECT-24590491
[Presentation] A novel locus of B6 mice on chromosome 12 plays a role in common process shared by SLE, RA, and Sjögren syndrome.2013
- Author(s)
  Toshiyuki Kaneko, Hirofumi Amano, Mareki Ohtsuji, Keiko Nishikawa, Shinya Kawano, Naomi Ohtsuji, Qingshun Lin, Hideki Okazaki, Hiromichi Tsurui, Hiroyuki Nishimura, Toshikazu Shirai, Yoshinori Takasaki, and Sachiko Hirose.
- Organizer
  5th East Asian Group of Rheumatology
- Place of Presentation
  ソウル,韓国
- Data Source
  KAKENHI-PROJECT-24590491
[Presentation] FcγレセプターIIB欠損マウスにおけるYaa遺伝子の与える影響2012
- Author(s)
  河野晋也、天野浩文、金子俊之、佐藤綾、林青順、広瀬幸子、高崎芳成
- Organizer
  第56回日本リウマチ学会総会・学術集会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-24590491
[Presentation] A novel locus of B6 mice on chromosome 12 plays a role in common process shared by SLE, RA, and Sjogren syndrome.2012
- Author(s)
  KANEKO Toshiyuki, AMANO Hirofumi, KAWANO Shinya, Lin Qingshun, OKAZAKI Hideki, TSURUI Hiromichi, NISHIMURA Hiroyuki, SHIRAI Toshikazu, TAKASAKI Yoshinari, HIROSE Sachiko.
- Organizer
  第41回日本免疫学会総会・学術集会
- Place of Presentation
  神戸
- Data Source
  KAKENHI-PROJECT-24590491
[Presentation] 重篤な関節リウマチを自然発症するFcγレセプターIIB欠損マウスの樹立2012
- Author(s)
  広瀬幸子、佐藤綾、林青順、天野浩文、大辻希樹、西村裕之
- Organizer
  第56回日本リウマチ学会総会・学術集会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-24590491
[Presentation] Phenotype conversion from RA to SLE in FcγRIIB-deficient B6 mice by Yaa mutation.2012
- Author(s)
  KAWANO Shinya, AMANO Hirofumi, LIN Qingshun, KANEKO Toshiyuki, NISHIKAWA Keiko, OKAZAKI Hideki, TSURUI Hiromichi, NISHIMURA Hiroyuki, SHIRAI Toshikazu, TAKASAKI Yoshinari, HIROSE Sachiko
- Organizer
  第41回日本免疫学会総会・学術集会
- Place of Presentation
  神戸
- Data Source
  KAKENHI-PROJECT-24590491
[Presentation] FTY720治療後のBXSBマウス腎炎における腎臓局所サイトカイン・ケモカインの発現の変化2011
- Author(s)
  安藤誠一郎、天野浩文、天野恵理、箕輪健太郎、渡邉崇、仲野総一郎、森本真司、戸叶嘉明、林青順、侯蓉、大辻希樹、広瀬幸子、高崎芳成
- Organizer
  第55回日本リウマチ学会総会・学術集会
- Place of Presentation
  神戸
- Data Source
  KAKENHI-PROJECT-21591272
[Presentation] 全身性エリテマトーデス剖検80例における病理所見と臨床経過に関する検討2011
- Author(s)
  今高之、山路健、杉本郁、宮下知子、小笠原倫大、建部一夫、天野浩文、津田裕士、橋本博史、高崎芳成
- Organizer
  第26回日本臨床リウマチ学会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-21591272
[Presentation] SLEとB細胞異常2011
- Author(s)
  天野浩文
- Organizer
  免疫疾患学会連合2011(日本臨床免疫学会総会)
- Place of Presentation
  東京
- Year and Date
  2011-09-16
- Data Source
  KAKENHI-PROJECT-21591272
[Presentation] 活動期SLE患者において血清中sCD138は高値を示す2011
- Author(s)
  箕輪健太郎、天野浩文、仲野総一郎、安藤誠一郎、渡邉崇、名切裕、天野恵理、戸叶嘉明、森本真司、高崎芳成
- Organizer
  第55回日本リウマチ学会総会・学術集会
- Place of Presentation
  神戸
- Data Source
  KAKENHI-PROJECT-21591272
[Presentation] 当科におけるループス腎炎V型の治療と予後の検討2011
- Author(s)
  森本真司、仲野総一郎、渡邉崇、天野浩文、高崎芳成
- Organizer
  第55回日本リウマチ学会総会・学術集会
- Place of Presentation
  神戸
- Data Source
  KAKENHI-PROJECT-21591272
[Presentation] Yaa-Mutation Induces Phenotype Shift From Rheumatoid Arthritis to Systemic Lupus Erythematosus in FcgRIIB-Deficient B6 Mice2011
- Author(s)
  Amano H, Kawano S, Kaneko T, Sato-Hayashizaki A, Lin Q, Takasaki Y and Hirose S.
- Organizer
  The75th National Meeting of American College of Rheumatology
- Place of Presentation
  Chicago
- Data Source
  KAKENHI-PROJECT-21591272
[Presentation] Yaa-Mutation induces phenotype shift from rheumatoid arthritis to systemic lupus enythematosus in FcgRIIB-deficient B6 mice2011
- Author(s)
  Amano H, 他
- Organizer
  The 75^<th> National Meeting of American College of Rheumatology
- Place of Presentation
  USA, Chicago
- Year and Date
  2011-11-05
- Data Source
  KAKENHI-PROJECT-21591272
[Presentation] SLEとB細胞異常2011
- Author(s)
  天野浩文, 安藤誠一, 箕輪健太郎, 金子俊之, 河野晋也, 仲野総一郎, 渡辺崇, 石原直樹, 天野恵理, 森本真司, 林青順, 広瀬幸子, 高崎芳成
- Organizer
  第39回日本臨床免疫学会総会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-21591272
[Presentation] FTY720によるBXSBマウスのループス腎炎抑制機序の解析2010
- Author(s)
  安藤誠一郎、天野浩文、天野恵理、渡邉崇、名切裕、森本真司、戸叶嘉明、林青順、大辻希樹、広瀬幸子、高崎芳成
- Organizer
  第54回日本リウマチ学会総会・学術集会
- Place of Presentation
  神戸
- Data Source
  KAKENHI-PROJECT-21591272
[Presentation] The hidden activation of plasma cell in SLE patients detected by soluble CD1382010
- Author(s)
  Minowa K, Amano H, Nakano S, Ando S, Watanabe T, Ishihara N, Nakiri Y, Morimoto S, Tokano Y, Takasaki Y.
- Organizer
  14th International Congress of Immunology Kobe
- Data Source
  KAKENHI-PROJECT-21591272
[Presentation] SLEモデルマウス脾臓辺縁帯B細胞形成における補体とB細胞抗原受容体の関与2010
- Author(s)
  天野浩文、天野恵理、安藤誠一郎、箕輪健太郎、森本真司、戸叶嘉明、広瀬幸子、高崎芳成
- Organizer
  第53回日本リウマチ学会総会・学術集会
- Place of Presentation
  神戸
- Data Source
  KAKENHI-PROJECT-21591272
[Presentation] SLEモデルマウス脾臓辺縁帯B細胞形成における補体とB細胞抗原受容体の関与2010
- Author(s)
  天野浩文、天野恵理、安藤誠一郎、箕輪健太郎、森本真司、戸叶嘉明、広瀬幸子、高崎芳成
- Organizer
  第54回日本リウマチ学会総会・学術集会
- Place of Presentation
  神戸
- Data Source
  KAKENHI-PROJECT-21591272
[Presentation] The role of complement and B cell antigen receptor on the development of marginal zone B cells in lupus-prone mice2010
- Author(s)
  Amano H, Amano E, Ando S, Minowa K, Morimoto S, Hirose S, Izui S, Takasaki Y.
- Organizer
  14th International Congress of Immunology Kobe
- Data Source
  KAKENHI-PROJECT-21591272
[Presentation] The role of complement and B cell antigen receptor on the development of marginal zone B cells in lupus-prone mice2010
- Author(s)
  Amano H, Amano E, Ando S, Minowa K, Watanabe T, Nakano S, Morimoto S, Hirose S, Takasaki Y, Izui S.
- Organizer
  14th Congress of the Asia Pacific League of Associations for Rheumatology(APLAR 2010)
- Place of Presentation
  Hong Kong
- Data Source
  KAKENHI-PROJECT-21591272
[Presentation] Toll-like receptor(TLR)とリウマチ性疾患(シンポジウム)2009
- Author(s)
  天野浩文、天野恵理、仲野総一郎、安藤誠一郎、箕輪健太郎、渡辺崇、森本真司、林青順、広瀬幸子、戸叶嘉明、高崎芳成
- Organizer
  第53回日本リウマチ学会総会・学術集会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-21591272
[Presentation] Toll-like receptor(TLR)とリウマチ性疾患2009
- Author(s)
  天野浩文、天野恵理、仲野総一郎、安藤誠一郎、箕輪健太郎、渡辺崇、森本真司、林青順、広瀬幸子、戸叶嘉明、高崎芳成
- Organizer
  日本リウマチ学会総会(第53回)シンポジウム
- Data Source
  KAKENHI-PROJECT-19591180
[Presentation] Toll-like receptor(TLR)とリウマチ性疾患2009
- Author(s)
  天野浩文
- Organizer
  第53回日本リウマチ学会総会・学術集会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-21591272
[Presentation] Increased CD14+CD62LlowCD16high “resident" Monocyte Subset in Systemic Lupus Erythematosus2008
- Author(s)
  Amano H, Ando S, Amano E, Nakano S, Minowa K, Watanabe T, Shinji Moritnoto, Yoshiaki Tokano, Yoshinari Takasaki.
- Organizer
  American College of Rheumatology
- Place of Presentation
  San Francisco
- Year and Date
  2008-10-28
- Data Source
  KAKENHI-PROJECT-19591180
[Presentation] Increased CD14^+CD62L^<low> CD16 high "resident" Monocyte Subset in Systemic Lupus Erythematosus2008
- Author(s)
  Amano H, Ando S, Amano E, Nakano S, Min owa K, Watanabe T, Shinji Morimoto, Tok ano Y, Takasaki Y
- Organizer
  アジア環太平洋リウマチ学会(第13回)
- Data Source
  KAKENHI-PROJECT-19591180
[Presentation] Efficient Differentiation of Gr-1 Positive Monocytes to Gr-1 Negative Monocytes and Dendritic Cells in the Yaa Model of Systemic Lupus Erythematosus2008
- Author(s)
  天野浩文、天野恵理、林青順、仲野総一郎、野澤和久、森本真司、戸叶嘉明、広瀬幸子、高崎芳成
- Organizer
  日本免疫学会総会(第38回)
- Data Source
  KAKENHI-PROJECT-19591180
[Presentation] BXSBマウスの末梢血単球増加におけるFcγレセプターの役割2008
- Author(s)
  天野浩文、天野恵理、安藤誠一郎、仲野総一郎、森本真司、戸叶嘉明、林青順、西村裕之、広瀬幸子、高崎芳成
- Organizer
  日本リウマチ学会総会(第52回)
- Data Source
  KAKENHI-PROJECT-19591180
[Presentation] Fc・R-dependent Expansion of Gr-1-Monocyte Subset in Lupus-Prone Mice2008
- Author(s)
  Amano H, Amano E, Lin Qingshun, Ando S, Nishimura H, Morimoto S, Hirose S, Takasaki Y
- Organizer
  日本免疫学会総会(第38回)
- Data Source
  KAKENHI-PROJECT-19591180
[Presentation] Increased CD14^+CD62Llow CD16^<high> "resident" Monocyte Subset in Systemic Lupus Erythematosus2008
- Author(s)
  Amano H, Ando S, Amano E, Nakano S, Minowa K, Watanabe T, Shinji Morimoto, Tokano Y, Takasaki Y
- Organizer
  アメリカリウマチ学会(第74回)
- Data Source
  KAKENHI-PROJECT-19591180
[Presentation] IgG Fc Receptor Contribution to the Development of Monocyotosis in Lupus Prone BXSB Mice2007
- Author(s)
  天野浩文、天野恵理、安藤誠一郎、仲野総一郎、森本真司、戸叶嘉明、林青順、西村裕之、広瀬幸子、高崎芳成
- Organizer
  日本免疫学会総会(第37回)
- Data Source
  KAKENHI-PROJECT-19591180
[Presentation] BXSBマウスの末梢血単球増加におけるFcγレセプターの役割2007
- Author(s)
  天野浩文、天野恵理、安藤誠一郎、仲野総一郎、森本真司、戸叶嘉明、林青順、広瀬幸子、高崎芳成
- Organizer
  日本臨床免疫学会総会(第35回)
- Data Source
  KAKENHI-PROJECT-19591180
[Presentation] BXSBマウスの単球由来の樹状細胞は抗原特異的T細胞の増殖を誘導する2007
- Author(s)
  天野浩文、野澤和久、森本真司、西村裕之、広瀬幸子、戸叶嘉明、高崎芳成
- Organizer
  日本リウマチ学会総会(第51回)
- Data Source
  KAKENHI-PROJECT-19591180
[Presentation] IgG Fc Receptor Contribution to the Development of Monocyotosis in Lupus Prone BXSB M2007
- Author(s)
  天野浩文
- Organizer
  日本免疫学会総会・学術集会(第37回)
- Place of Presentation
  東京、高輪プリンスホテル
- Year and Date
  2007-11-21
- Data Source
  KAKENHI-PROJECT-19591180
[Presentation] Mechanism of phenotype conversion from rheumatoid arthritis to lupus in FcγRIIB-deficient C57BL/6 Yaa mice
- Author(s)
  S. Kawano, H. Amano, Q. Lin, K. Nishikawa , H. Tsurui, T. Shirai, S. Hirose, Y. Takasaki
- Organizer
  The European League Against Rheumatism
- Place of Presentation
  ローマ、イタリア
- Year and Date
  2015-06-10 – 2015-06-13
- Data Source
  KAKENHI-PROJECT-25461486
[Presentation] Phenotype conversion from rheumatoid arthritis to systetmic lupus erythematosus by introduction of Yaa mutation into FcγRIIB-deficient C57BL/6 mice.
- Author(s)
  Shinya Kawano, Qingshun Lin, Hirofumi Amano, Toshiyuki Kaneko, Keiko Nishikawa, Hiromichi Tsurui, Norihiro Tada, Hiroyuki Nishimura, Toshiyuki Takai, Toshikazu Shirai, Sachiko Hirose, Yoshinari Takasaki.
- Organizer
  第58回日本リウマチ学会総会・学術集会
- Place of Presentation
  東京、グランドプリンスホテル新高輪
- Year and Date
  2014-04-24 – 2014-04-26
- Data Source
  KAKENHI-PROJECT-24590491
[Presentation] TNFα and IL-6 but not IL-17 are critical in the pathogenesis of rheumatoid arthritis spontaneously occurring in a unique FcγRIIB-deficient mouse model.
- Author(s)
  OHTSUJI Mareki, OKAZAKI Hideki, LIN Qingshun, NISHIKAWA Keiko, NISHIMURA Hiroyuki, AMANO Hirofumi, NISHIMOTO Norihiro, SHIRAI Toshikazu, HIROSE Sachiko.
- Organizer
  第43回日本免疫学会総会・学術集会
- Place of Presentation
  京都、京都国際会議場
- Year and Date
  2014-12-10 – 2014-12-12
- Data Source
  KAKENHI-PROJECT-24590491
[Presentation] B cell specific deficiency of FcγRIIB is required for autoantibody production, but not enough for early onset of lupus nephritis in B6.Yaa mice.
- Author(s)
  Qingshun Lin, Keiko Nishikawa, Mareki Ohtsuji, Hiroyuki Nishimura, Hirofumi Amano, Sachiko Hirose.
- Organizer
  第58回日本リウマチ学会総会・学術集会
- Place of Presentation
  東京、グランドプリンスホテル新高輪
- Year and Date
  2014-04-24 – 2014-04-26
- Data Source
  KAKENHI-PROJECT-24590491
[Presentation] B cell specific FcγRIIb deficiency is enough for autoantibody production, but not for the progression of Yaa-related lupus nephritis.
- Author(s)
  LIN Qingshun, TSURUI Hiromichi, NISHIKAWA Keiko, AMANO Hirofumi, OHTSUJI Mareki, NISHIMURA Hiroyuki, SHIRAI Toshikazu, VERBEEK Sjef, HIROSE Sachiko.
- Organizer
  第43回日本免疫学会総会・学術集会
- Place of Presentation
  京都、京都国際会議場
- Year and Date
  2014-12-10 – 2014-12-12
- Data Source
  KAKENHI-PROJECT-24590491
[Presentation] Genetic dissection of FcγRIIb deficiency and autoimmune-type SLAM haplotype reveals the important role of FcγRIIb in Yaa-related lupus nephritis.
- Author(s)
  NISHIKAWA Keiko, LIN Qingshun, TSURUI Hiromichi, AMANO Hirofumi, NISHIMURA Hiroyuki, SHIRAI Toshikazu, TAKAI Tosjiyuki, HIROSE Sachiko.
- Organizer
  第43回日本免疫学会総会・学術集会
- Place of Presentation
  京都、京都国際会議場
- Year and Date
  2014-12-10 – 2014-12-12
- Data Source
  KAKENHI-PROJECT-24590491
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1. HIROSE Sachiko (00127127)

# of Collaborated Projects: 5 results

# of Collaborated Products: 47 results
2. TAKASAKI Yoshinari (80154772)

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
3. NISHIMURA Hiroyuki (60189313)

# of Collaborated Projects: 1 results

# of Collaborated Products: 10 results
4. SUZUKI Hitoshi

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
5. TSURUI Hiromichi

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
6. 長尾雅史

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
7. 奥健志

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
8. 清水潤

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
9. 多田昇弘

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

AMANO Hirofumi 天野 浩文

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SLEに合併する骨壊死症のTLR7およびFcγⅡB受容体を標的とした発症阻止戦略Principal Investigator

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Elucidation of the pathology of SLE by TLR7 regulation and development of novel antibody therapeutics.Principal Investigator

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Role of IL-10 on phenotypical change from RA to SLE using FcgRIIB-deficient micePrincipal Investigator

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Role of FcgRIIB for autoantibody production inside and outside of germinal centers

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Effect of SLAM mutation and activating and inhibitory FcR on autoimmune prone mice

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Genotype identification of RA and SLE using Fc gamma RIIB-deficient B6 mice.Principal Investigator

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Epistatic interaction of FcgammaRIIB and Sle16 polymorphism in rheumatoid arthritis

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Immunological disorder via Toll like receptors expressed by sex chromosome in systemic lupus erythematosusPrincipal Investigator

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Defect of Marginal Zone B cell in Yaa Associated Lupus Prone-micePrincipal Investigator

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SLEモデルマウスにおけるYaa遺伝子変異によるマージナルゾーンB細胞の分化異常Principal Investigator

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[Book] リウマチ病学テキスト（改訂第3版）2022

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[Book] 膠原病に伴う間質性肺疾患 診断・治療指針2020「第2章各論4全身性エリテマトーデス」「第5章 薬物療法以外1アフェレシス療法」2020

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[Book] 今日の治療指針 2019年版［IgG4関連疾患］2019

Author(s)

Publisher

ISBN

AMANO Hirofumi 天野浩文

[Book] 膠原病に伴う間質性肺疾患　診断・治療指針2020「第2章各論4全身性エリテマトーデス」「第5章薬物療法以外1アフェレシス療法」2020

[Book] 今日の治療指針　2019年版［IgG4関連疾患］2019

[Journal Article] Genetic dissection of HLA-DRB115:01 and XL9 region variants in Japanese patients with systemic lupus erythematosus: primary role for HLA-DRB115:012023