Obayashi Eiji 尾林栄治

… Alternative Names

OBAYAHI Eiji 尾林栄治

尾林栄治オバヤシエイジ

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Researcher Number	50321740
Other IDs
Affiliation (Current)	2025: 島根大学, 学術研究院医学・看護学系, 准教授
Affiliation (based on the past Project Information) *help	2018 – 2024: 島根大学, 学術研究院医学・看護学系, 准教授 2011 – 2013: 島根大学, 医学部, 助教 2010: Yokohama City University, 大学院・生命ナノシステム科学研究科, 特任助教 2009 – 2010: Yokohama City University, 生命ナノシステム科学研究科, 特任助教 2000 – 2001: 理化学研究所, 生体物理化学研究室, 基礎科学特別研究員
Review Section/Research Field	Principal Investigator Basic Section 43020:Structural biochemistry-related / Structural biochemistry / Biological Sciences / Virology / Structural biochemistry
Keywords	Principal Investigator 立体構造解析 / RNAスプライシング / スプライシング / 構造解析 / X線結晶構造解析 / 翻訳 / 蛋白質 / 翻訳開始 / タンパク質 / RNA … More / RNAポリメラーゼ / インフルエンザ / cGMP合成部位 / ヘム結合部位 / 蛋白質結晶化 / 大腸菌大量発現系 / グアニル酸シクラーゼ / 一酸化窒素 Less

スプライシングにおけるイントロン認識機構と病気発症メカニズムの解明Principal Investigator
- Principal Investigator
  
  尾林栄治
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 43020:Structural biochemistry-related
- Research Institution
  Shimane University
Effects of disease-associated mutations in splicing proteins on RNA splicingPrincipal Investigator
- Principal Investigator
  
  Obayashi Eiji
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 43020:Structural biochemistry-related
- Research Institution
  Shimane University
Elucidation of the intron recognition mechanism by U2AF1Principal Investigator
- Principal Investigator
  
  Obayashi Eiji
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 43020:Structural biochemistry-related
- Research Institution
  Shimane University
Ｕ２ＡＦ複合体によるイントロン認識機構の構造生物学的研究Principal Investigator
- Principal Investigator
  
  尾林栄治
- Project Period (FY)
  2011 – 2012
- Research Category
  
  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
- Review Section
  
  Biological Sciences
- Research Institution
  Shimane University
structural studies of the mechanism of eukaryotic translation initiationPrincipal Investigator
- Principal Investigator
  
  OBAYASHI EIJI
- Project Period (FY)
  2011 – 2013
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Structural biochemistry
- Research Institution
  Shimane University
Structural studies on influenza viral RNA polymerase for designing new anti-viral drugPrincipal Investigator
- Principal Investigator
  
  OBAYAHI Eiji
- Project Period (FY)
  2009 – 2010
- Research Category
  
  Grant-in-Aid for Young Scientists (A)
- Research Field
  
  Virology
- Research Institution
  Yokohama City University
一酸化窒素センサー蛋白質グアニル酸シクラーゼの分子内情報伝達機構の解明Principal Investigator
- Principal Investigator
  
  尾林栄治
- Project Period (FY)
  2000 – 2001
- Research Category
  
  Grant-in-Aid for Encouragement of Young Scientists (A)
- Research Field
  
  Structural biochemistry
- Research Institution
  The Institute of Physical and Chemical Research

All 2022 2020 2019 2012 2011 2010 2009

All Journal Article Presentation

[Journal Article] Generation of antagonistic monoclonal antibodies against the neoepitope of active mouse interleukin (IL)-18 cleaved by inflammatory caspases2022
- Author(s)
  Uchida Yuki、Nariai Yuko、Obayashi Eiji、Tajima Yoshitsugu、Koga Tomohiro、Kawakami Atsushi、Urano Takeshi、Kamino Hiroki
- Journal Title
  
  Archives of Biochemistry and Biophysics
  
  Volume: 727 Pages: 109322-109322
- DOI
  10.1016/j.abb.2022.109322
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K06049, KAKENHI-PROJECT-21K08438, KAKENHI-PROJECT-21K08753, KAKENHI-PROJECT-20K07635, KAKENHI-PROJECT-20K16443
[Journal Article] Elucidation of the aberrant 3′ splice site selection by cancer-associated mutations on the U2AF12020
- Author(s)
  Yoshida Hisashi、Park Sam-Yong、Sakashita Gyosuke、Nariai Yuko、Kuwasako Kanako、Muto Yutaka、Urano Takeshi、Obayashi Eiji
- Journal Title
  
  Nature Communications
  
  Volume: 11 Issue: 1 Pages: 4744-4752
- DOI
  10.1038/s41467-020-18559-6
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K06086, KAKENHI-PROJECT-20H01007
[Journal Article] Nucleus Accumbens-Associated Protein 1 Binds DNA Directly through the BEN Domain in a Sequence-Specific Manner2020
- Author(s)
  Nakayama Naomi、Sakashita Gyosuke、Nagata Takashi、Kobayashi Naohiro、Yoshida Hisashi、Park Sam-Yong、Nariai Yuko、Kato Hiroaki、Obayashi Eiji、Nakayama Kentaro、Kyo Satoru、Urano Takeshi
- Journal Title
  
  Biomedicines
  
  Volume: 8 Issue: 12 Pages: 608-608
- DOI
  10.3390/biomedicines8120608
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K07307, KAKENHI-PROJECT-18K06086, KAKENHI-PROJECT-18K06152, KAKENHI-PROJECT-20H01007
[Journal Article] Generation and characterization of antagonistic anti-human interleukin (IL)-18 monoclonal antibodies with high affinity: Two types of monoclonal antibodies against full-length IL-18 and the neoepitope of inflammatory caspase-cleaved active IL-18.2019
- Author(s)
  Nariai Y, Kamino H, Obayashi E, Kato H, Sakashita G, Sugiura T, Migita K, Koga T, Kawakami A, Sakamoto K, Kadomatsu K, Nakakido M, Tsumoto K, Urano T.
- Journal Title
  
  Archives of Biochemistry and Biophysics
  
  Volume: 663 Pages: 71-82
- DOI
  10.1016/j.abb.2019.01.001
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K08983, KAKENHI-PROJECT-18K05556, KAKENHI-PROJECT-18K06086, KAKENHI-PROJECT-16H02420, KAKENHI-PROJECT-16H05139, KAKENHI-PROJECT-19H00340, KAKENHI-PROJECT-17H06109
[Journal Article] Crystal structures of penicillin-binding protein 3 (PBP3) from methicillin-resistant Staphylococcus aureus in the apo and cefotaxime-bound forms2012
- Author(s)
  Yoshida H, Kawai F, Obayashi E, Akashi S, Roper DI, Tame JR, Park SY
- Journal Title
  
  J Mol Biol
  
  Volume: 423 Issue: 3 Pages: 351-364
- DOI
  10.1016/j.jmb.2012.07.012
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20227009, KAKENHI-PROJECT-22370044, KAKENHI-PROJECT-22570120, KAKENHI-PROJECT-23570143, KAKENHI-PLANNED-21113003, KAKENHI-PUBLICLY-23112717
[Journal Article] Park Crystal structure of penicillin-binding protein 3 (PBP3) from methicillin-resistant Staphylococcus aureus in the apo and cefotaxime-bound forms2012
- Author(s)
  H. Yoshida, F. Kawai, E. Obayashi, S. Akashi, D. I. Roper, J. R. H. Tame, and S.-Y.
- Journal Title
  
  Journal of Molecular Biology
  
  Volume: 423 Pages: 351-364
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23570143
[Journal Article] Oxygen binding and redox properties of the heme in soluble guanylate cyclase: Implications for the mechanism of ligand discrimination2011
- Author(s)
  R. Makino, S.-Y. Park, E. Obayashi, T. Iizuka, H. Hori and Y. Shiro
- Journal Title
  
  Journal of Biological Chemistry
  
  Volume: 286 Pages: 15678-15687
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23570143
[Journal Article] Oxygen binding and redox properties of the heme in soluble guanylate cyclase : Implications for the mechanism of ligand discrimination2011
- Author(s)
  R. Makino, S.-Y. Park, E. Obayashi, T. Iizuka, H. Hori and Y. Shiro.
- Journal Title
  
  Journal of Biological Chemistry
  
  Volume: 286 Pages: 15678-15687
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23570143
[Journal Article] Oxygen binding and redox properties of the heme in soluble guanylate cyclase : Implications for the mechanism of ligand discrimination2011
- Author(s)
  R.Makino, S.-Y.Park, E.Obayashi, T.Iizuka, H.Hori, Y.Shiro
- Journal Title
  
  Journal of Biological Chemistry
  
  Volume: 286 Pages: 15678-15687
- Peer Reviewed
- Data Source
  KAKENHI-PUBLICLY-23112717
[Journal Article] インフルエンザウイルスRNAポリメラーゼの構造解析と創薬研究2010
- Author(s)
  杉山佳奈子、尾林栄治、吉田尚史、朴三用
- Journal Title
  
  日本結晶学会誌
  
  Volume: 52 Pages: 271-278
- NAID
  10027673105
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21689014
[Journal Article] インフルエンザウイルスRNAポリメラーゼの構造解析と創薬研究2010
- Author(s)
  杉山佳奈子、尾林栄治、吉田尚史、朴三用
- Journal Title
  
  日本結晶学会誌 52巻
  
  Pages: 271-278
- NAID
  10027673105
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21689014
[Journal Article] Structural insight into the essential PB1-PB2 subunit contact of the influenza virus RNA polymerase2009
- Author(s)
  K.Sugiyama, E.Obayashi, A.Kawaguchi, Y.Suzuki, J.R.H.Tame, K.Nagata, S.-Y.Park
- Journal Title
  
  EMBO Journal Vol.28
  
  Pages: 1803-1811
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21689014
[Journal Article] インフルエンザ増殖の謎2009
- Author(s)
  尾林栄治、朴三用、ついに解明!
- Journal Title
  
  化学 64巻
  
  Pages: 25-29
- Data Source
  KAKENHI-PROJECT-21689014
[Journal Article] Structural insight into the essential PB1-PB2 subunit contact of the influenza virus RNA polymerase2009
- Author(s)
  K.Sugiyama, E.Obayashi, A.Kawaguchi, Y.Suzuki, J.R.H.Tame, K.Nagata, S.-Y.Park
- Journal Title
  
  EMBO Journal 28巻
  
  Pages: 1803-1811
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21689014
[Presentation] The structural study on influenza RNA polymerase for designing new anti-viral drug2010
- Author(s)
  Eiji Obayashi
- Organizer
  The 10th conference of the Asian Crystallographic Association
- Place of Presentation
  BEXCO、釜山(韓国)(招待講演)
- Year and Date
  2010-11-02
- Data Source
  KAKENHI-PROJECT-21689014
[Presentation] The structural study on influenza RNA polymerase for designing new anti-viral drug2010
- Author(s)
  Eiji Obayashi(尾林栄治)
- Organizer
  The 10^<th> conference of the Asian Crystallographic Association
- Place of Presentation
  BEXCO、釜山(韓国)(招待講演)
- Year and Date
  2010-11-02
- Data Source
  KAKENHI-PROJECT-21689014
[Presentation] インフルエンザウイルスのRNAポリメラーゼサブユニットPB1-PB2サブユニト間相互作用の解明2010
- Author(s)
  杉山佳奈子、尾林栄治、川口敦史、鈴木由佳理、テイムジェレミー、永田恭介、朴三用
- Organizer
  第47回日本蛋白質科学会
- Place of Presentation
  北海道大学
- Data Source
  KAKENHI-PROJECT-21689014
[Presentation] インフルエンザウイルスのRNAポリメラーゼサブユニットPA-PB1サブユニト間相互作用の解明2010
- Author(s)
  吉田尚史、尾林栄治、河合文啓、川口敦史、永田恭介、テイムジェレミー、朴三用
- Organizer
  第47回日本蛋白質科学会
- Place of Presentation
  北海道大学
- Data Source
  KAKENHI-PROJECT-21689014
[Presentation] インフルエンザウイルスのRNAポリメラーゼにおけるサブユニット間相互作用2009
- Author(s)
  尾林栄治
- Organizer
  日本生物物理学会第47回年会
- Place of Presentation
  アスティ徳島
- Year and Date
  2009-10-30
- Data Source
  KAKENHI-PROJECT-21689014

1. 浦野健 (70293701)

# of Collaborated Projects: 3 results

# of Collaborated Products: 3 results
2. NAGATA Takashi

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
3. 明石知子

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
4. 杉浦智子

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Obayashi Eiji 尾林 栄治

OBAYAHI Eiji 尾林 栄治

尾林 栄治 オバヤシ エイジ

Research Projects

Research Products

Co-Researchers

スプライシングにおけるイントロン認識機構と病気発症メカニズムの解明Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Effects of disease-associated mutations in splicing proteins on RNA splicingPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Elucidation of the intron recognition mechanism by U2AF1Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Ｕ２ＡＦ複合体によるイントロン認識機構の構造生物学的研究Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

structural studies of the mechanism of eukaryotic translation initiationPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Structural studies on influenza viral RNA polymerase for designing new anti-viral drugPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

一酸化窒素センサー蛋白質グアニル酸シクラーゼの分子内情報伝達機構の解明Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Generation of antagonistic monoclonal antibodies against the neoepitope of active mouse interleukin (IL)-18 cleaved by inflammatory caspases2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Elucidation of the aberrant 3′ splice site selection by cancer-associated mutations on the U2AF12020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Nucleus Accumbens-Associated Protein 1 Binds DNA Directly through the BEN Domain in a Sequence-Specific Manner2020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Generation and characterization of antagonistic anti-human interleukin (IL)-18 monoclonal antibodies with high affinity: Two types of monoclonal antibodies against full-length IL-18 and the neoepitope of inflammatory caspase-cleaved active IL-18.2019

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Crystal structures of penicillin-binding protein 3 (PBP3) from methicillin-resistant Staphylococcus aureus in the apo and cefotaxime-bound forms2012

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Park Crystal structure of penicillin-binding protein 3 (PBP3) from methicillin-resistant Staphylococcus aureus in the apo and cefotaxime-bound forms2012

Author(s)

Journal Title

Data Source

[Journal Article] Oxygen binding and redox properties of the heme in soluble guanylate cyclase: Implications for the mechanism of ligand discrimination2011

Author(s)

Journal Title

Obayashi Eiji 尾林栄治

OBAYAHI Eiji 尾林栄治

尾林栄治オバヤシエイジ