Koshino Hiroyuki 越野広雪

… Alternative Names

越野広雪コシノヒロユキ

KOSHINO Hiroyuki 越野広雪

HIROYUKI Koshino 越野広雪

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Researcher Number	50321758
Other IDs
Affiliation (Current)	2025: 国立研究開発法人理化学研究所, 環境資源科学研究センター, ユニットリーダー
Affiliation (based on the past Project Information) *help	2021 – 2024: 国立研究開発法人理化学研究所, 環境資源科学研究センター, ユニットリーダー 2016 – 2018: 国立研究開発法人理化学研究所, 環境資源科学研究センター, ユニットリーダー 2008 – 2010: The Institute of Physical and Chemical Research, 物質構造解析チーム, チームヘッド 2002: 理化学研究所, 分子構造解析室, 室長(副主任研究員待遇) 2001: 理化学研究所, 分子構造解析室, 室長(研究職) … More 2000: Institute for Physical and Chemical Research, Division of Analysis of Molecular Structures, Senior Researcher, 分子構造解析室, 室長 2000: 理化学研究所, 分子構造解析室, 研究員 1999: 理化学研究所, フロンティア研究システム, 研究員 Less
Review Section/Research Field	Principal Investigator Bioorganic chemistry / Bioproduction chemistry/Bioorganic chemistry / Science and Engineering Except Principal Investigator Basic Section 38040:Bioorganic chemistry-related / Applied molecular and cellular biology
Keywords	Principal Investigator 構造訂正 / 立体化学 / 核磁気共鳴 / 有機化学 / 機器分析 / 天然物化学 / ピロン / ポリフェノール / ポリケタイド / デカリン … More / 構造解析 / フェノール / テルペノイド / NMR / 天然有機化合物 / INADEQUATE法 / ロンギフォレン / テレファンチンG / スピン結合定数 / ラクトン / エステル / アルデヒド / ケトン / 立体配座 / テルフェニル / 環状ケトン / フォモプシンB / CNMR / CAST / データベース / 化学シフト / 有機化合物 … More Except Principal Investigator Kuji amber / Oligosaccharide / Vaccine / Neisseria gonorrhoeae / LPS / C2C12　cells / H4IIE cells / Spirolactone / Chemical space / Saccharomyces cerevisiae / アッセイ系 / 単離精製 / 抗アレルギー / ユビキチンリガーゼ / 中国撫順産琥珀 / コーパル / RBL-2H3細胞 / rsp5A401E株 / kujigamberol / 遺伝子変異酵母株 / 久慈産琥珀 / Chemical Bioligy / mutant yeast / seco-kujigamberol / Chemiical Biology / Social implementation / Anti-allergy / Spanish amber / Mutant yeast / seco-Kujigamberol / Kujigamberol / Lipooligosaccharide (LOS / 免疫化学 / りん菌 / オリゴ糖 / 免役化学 / 構造解析 / エピトープ / ワクチン / リポ多糖 / LOS / Lipooligosacharide(LOS)c Less

Integrated study on amber's unique chemical space and diverse biological activities
- Principal Investigator
  
  木村賢一
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 38040:Bioorganic chemistry-related
- Research Institution
  Iwate University
Integrated analysis of chemical reaction products in Cretaceous amber and their biological activity
- Principal Investigator
  
  KIMURA Ken-ichi
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 38040:Bioorganic chemistry-related
- Research Institution
  Iwate University
Evaluation of structure detemination of natural products by using 13C NMR chemical shifts and study of structural revisionPrincipal Investigator
- Principal Investigator
  
  Koshino Hiroyuki
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Bioorganic chemistry
- Research Institution
  Institute of Physical and Chemical Research
A new method for analysis of stereochemistry in carbonyl containing compounds using chemical shifts and spin coupling constant valuesPrincipal Investigator
- Principal Investigator
  
  KOSHINO Hiroyuki
- Project Period (FY)
  2008 – 2010
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Bioproduction chemistry/Bioorganic chemistry
- Research Institution
  The Institute of Physical and Chemical Research
立体化学と考慮した^<13>C-NMR化学シフト予測システム開発と立体配置決定への応用Principal Investigator
- Principal Investigator
  
  越野広雪
- Project Period (FY)
  2001 – 2002
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Science and Engineering
- Research Institution
  The Institute of Physical and Chemical Research
Development of pseudo-LOS vaccines
- Principal Investigator
  
  RYOHEI Yamasaki
- Project Period (FY)
  1998 – 2000
- Research Category
  
  Grant-in-Aid for Scientific Research (A).
- Research Field
  
  Applied molecular and cellular biology
- Research Institution
  TOTTORI UNIVERSITY

All 2024 2023 2022 2021 2019 2018 2017 2016 2011 2010 2009 2008 Other

All Journal Article Presentation

[Journal Article] Isolation of a spirolactone norditerpenoid as a yeast Ca^2+ signal transduction inhibitor from Kuji amber and evaluation of its effects on PPM1A activity2019
- Author(s)
  Shimizu Eisaku、Koshino Hiroyuki、Noro Aoi、Maruyama Miku、Shimoda Nozomu、Uesugi Shota、Ohnishi Motoko、Kimura Ken-ichi
- Journal Title
  
  Fitoterapia
  
  Volume: 134 Pages: 290-296
- DOI
  10.1016/j.fitote.2019.02.027
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16H04910, KAKENHI-PROJECT-15K01810, KAKENHI-PROJECT-16K07724, KAKENHI-PROJECT-19K14046
[Journal Article] Isolation of yeast Ca2+ signal transduction inhibitors from the Early Cretaceous Burmese amber2019
- Author(s)
  Uchida Takeshi、Koshino Hiroyuki、Abe Junpei、Hakozaki Mayuka、Yamada Hidetoshi、Kimura Ken-ichi
- Journal Title
  
  Fitoterapia
  
  Volume: 134 Pages: 422-428
- DOI
  10.1016/j.fitote.2019.02.018
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16K07724
[Journal Article] Isolation of Peribysins O, P, and Q from Periconia macrospinosa KT3863, and Configurational Reinvestigation of Peribysin E Diacetate from Periconia byssoides OUPS-N1332019
- Author(s)
  Kota Inose, Kazuaki Tanaka, Takeshi Yamada, Hiroyuki Koshino, Masaru Hashimoto
- Journal Title
  
  J. Nat. Prod.
  
  Volume: 82 Issue: 4 Pages: 911-918
- DOI
  10.1021/acs.jnatprod.8b01001
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15H04491, KAKENHI-PROJECT-16K07724
[Journal Article] Biosynthetic study of conidiation-inducing factor conidiogenone: Heterologous production and cyclization mechanism of a key bifunctional diterpene synthase2019
- Author(s)
  Shiina, T.; Nakagawa, K.; Fujisaki, Y.; Ozaki, T.; Liu, C.; Toyomasu, T.; Hashimoto, M.; Koshino, H.; Minami, A.; Kawaide, H.; Oikawa, H.
- Journal Title
  
  Biosci. Biotechnol. Biochem.
  
  Volume: 83 Issue: 2 Pages: 192-201
- DOI
  10.1080/09168451.2018.1536518
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-16H06446, KAKENHI-PUBLICLY-17H05425, KAKENHI-PROJECT-15H04491, KAKENHI-PROJECT-16K07724, KAKENHI-PROJECT-19H02891
[Journal Article] The value of universally available raw NMR data for transparency, reproducibility, and integrity in natural product research2019
- Author(s)
  McAlpine J. B.、Chen S-N、Kutateladze A、MacMillan J B.、Appendino G、Barison A、Beniddir M. A.、Biavatti M W.、Bluml S、Boufridi A、Butler M S.、Capon R J.、Choi Y H.、Coppage D、Crews P、Crimmins M T.、Jeannerat D、Koshino Hiroyuki、Pauli G. F. et al
- Journal Title
  
  Natural Product Reports
  
  Volume: 36 Issue: 1 Pages: 35-107
- DOI
  10.1039/c7np00064b
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K07724
[Journal Article] Convenient Synthesis of Thiohydantoins, Imidazole-2-thiones and Imidazo[2,1-b]thiazol-4-iums from Polymer-Supported α-Acylamino Ketones2018
- Author(s)
  Kralova Petra、Malon Michal、Koshino Hiroyuki、Soural Miroslav
- Journal Title
  
  Molecules
  
  Volume: 23 Issue: 4 Pages: 976-976
- DOI
  10.3390/molecules23040976
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K07724
[Journal Article] Amberene and 1-methylamberene, isolated and identified from Kuji amber (Japan)2018
- Author(s)
  Kawamura Tetsuaki、Koshino Hiroyuki、Nakamura Takemichi、Nagasawa Yoshiyuki、Nanao Hidetaka、Shirai Masayuki、Uesugi Shota、Ohno Misa、Kimura Ken-ichi
- Journal Title
  
  Organic Geochemistry
  
  Volume: 120 Pages: 12-18
- DOI
  10.1016/j.orggeochem.2018.02.014
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16K07724
[Journal Article] Synthesis of polyozellin, a prolyl oligopeptidase inhibitor, and its structural revision2018
- Author(s)
  Takahashi Shunya、Kawano Takahiro、Nakajima Natsumi、Suda Yasuaki、Usukhbayar Narandulam、Kimura Ken-ichi、Koshino Hiroyuki
- Journal Title
  
  Bioorganic & Medicinal Chemistry Letters
  
  Volume: 28 Issue: 5 Pages: 930-933
- DOI
  10.1016/j.bmcl.2018.01.054
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16K07724, KAKENHI-PROJECT-15K07421
[Journal Article] Convergent Synthesis of the ent-ZA′B′C′D′-Ring System of Maitotoxin2017
- Author(s)
  Saito Tatsuo、Morita Masayuki、Koshino Hiroyuki、Sodeoka Mikiko、Nakata Tadashi
- Journal Title
  
  Organic Letters
  
  Volume: 19 Issue: 12 Pages: 3203-3206
- DOI
  10.1021/acs.orglett.7b01301
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16K07724, KAKENHI-PROJECT-16K18841
[Journal Article] The industrial anaerobe Clostridium acetobutylicum uses polyketides to regulate cellular differentiation2017
- Author(s)
  Herman Nicolaus A.、Kim Seong Jong、Li Jeffrey S.、Cai Wenlong、Koshino Hiroyuki、Zhang Wenjun
- Journal Title
  
  Nature Communications
  
  Volume: 8 Issue: 1 Pages: 1514-1514
- DOI
  10.1038/s41467-017-01809-5
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K07724
[Journal Article] Increased metabolite production by deletion of an HDA1-type histone deacetylase in the phytopathogenic fungi, Magnaporthe oryzae (Pyricularia oryzae) and Fusarium asiaticum.2017
- Author(s)
  2.Maeda K., Izawa M., Nakajima Y., Jin Q., Hirose T., Nakamura T., Koshino H., Kanamaru K., Ohsato S., Kamakura T., Kobayashi T., Yoshida M., Kimura M.
- Journal Title
  
  Lett. Appl. Microbiol.
  
  Volume: 65 Issue: 5 Pages: 446-452
- DOI
  10.1111/lam.12797
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16K07623, KAKENHI-PROJECT-16K07724, KAKENHI-PROJECT-17K08262, KAKENHI-PROJECT-26221204
[Journal Article] Study of 2-aminoquinolin-4(1H)-one under Mannich and retro-Mannich reaction2017
- Author(s)
  Funk Petr、Motyka Kamil、Soural Miroslav、Malon Michal、Koshino Hiroyuki、Kusz Joachim、Hlavac Jan
- Journal Title
  
  PLOS ONE
  
  Volume: 12 Issue: 5 Pages: e0175364-e0175364
- DOI
  10.1371/journal.pone.0175364
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K07724
[Journal Article] N1, N14-diferuloylspermine as an antioxidative phytochemical contained in leaves of Cardamine fauriei2017
- Author(s)
  Abe Keima、Matsuura Hideyuki、Ukai Mitsuko、Shimura Hanako、Koshino Hiroyuki、Suzuki Takashi
- Journal Title
  
  Bioscience, Biotechnology, and Biochemistry
  
  Volume: 81 Issue: 10 Pages: 1855-1860
- DOI
  10.1080/09168451.2017.1356214
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16K07724
[Journal Article] Neomacrophorin X, a [4.4.3]Propellane-Type Meroterpenoid from Trichoderma sp. 1212-032017
- Author(s)
  Kusakabe Kazuaki、Honmura Yuna、Uesugi Shota、Tonouchi Akio、Maeda Hayato、Kimura Ken-ichi、Koshino Hiroyuki、Hashimoto Masaru
- Journal Title
  
  Journal of Natural Products
  
  Volume: 80 Issue: 5 Pages: 1484-1492
- DOI
  10.1021/acs.jnatprod.6b01177
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16K07724, KAKENHI-PROJECT-15H04491, KAKENHI-PROJECT-16K14910
[Journal Article] Hitoyol A and B, Two Norsesquiterpenoids from the Basidiomycete Coprinopsis cinerea2017
- Author(s)
  Otaka Junnosuke、Hashizume Daisuke、Masumoto Yui、Muranaka Atsuya、Uchiyama Masanobu、Koshino Hiroyuki、Futamura Yushi、Osada Hiroyuki
- Journal Title
  
  Organic Letters
  
  Volume: 19 Issue: 15 Pages: 4030-4033
- DOI
  10.1021/acs.orglett.7b01784
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16K07724, KAKENHI-PUBLICLY-17H05430, KAKENHI-PROJECT-17H06173, KAKENHI-PROJECT-15H02445
[Journal Article] Biosynthesis of isonitrile lipopeptides by conserved nonribosomal peptide synthetase gene clusters in Actinobacteria2017
- Author(s)
  Harris Nicholas C.、Sato Michio、Herman Nicolaus A.、Twigg Frederick、Cai Wenlong、Liu Joyce、Zhu Xuejun、Downey Jordan、Khalaf Ryan、Martin Joelle、Koshino Hiroyuki、Zhang Wenjun
- Journal Title
  
  Proceedings of the National Academy of Sciences
  
  Volume: 114 Issue: 27 Pages: 7025-7030
- DOI
  10.1073/pnas.1705016114
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K07724
[Journal Article] Hydroxylations of trichothecene rings in the biosynthesis of Fusarium trichothecenes: evolution of alternative pathways in the nivalenol chemotype.2016
- Author(s)
  Maeda K, Tanaka A, Sugiura R, Koshino H, Tokai T, Sato M, Nakajima Y, Tanahashi Y, Kanamaru K, Kobayashi T, Nishiuchi T, Fujimura M, Takahashi-Ando N, Kimura M.
- Journal Title
  
  Environ Microbiol.
  
  Volume: 18 Issue: 11 Pages: 3798-3811
- DOI
  10.1111/1462-2920.13338
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-26450053, KAKENHI-PROJECT-16K07724
[Journal Article] Isolation of coralmycins A and B, potent anti-Gram negative compounds from the myxobacteria Corallococcus coralloides M232016
- Author(s)
  Kim Y. J., Kim H-J., Kim G-W., Cho K., Takahashi S., Koshino H., Kim W-G.
- Journal Title
  
  J. Nat. Prod.
  
  Volume: 79 Issue: 9 Pages: 2223-2228
- DOI
  10.1021/acs.jnatprod.6b00294
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K07421, KAKENHI-PROJECT-16K07724
[Journal Article] Yeast Ca2+-signal transduction inhibitors isolated from Dominican amber prevent the degranulation of RBL-2H3 cells through the inhibition of Ca2+-influx2016
- Author(s)
  Tomomi Abe, Miki Kobayashi, Yusuke Okawa, Tomoki Inui, Jun Yoshida, Hironori Higashio, Hisao Shinden, Shota Uesugi, Hiroyuki Koshino, Ken-ichi Kimura
- Journal Title
  
  Fitoterapia
  
  Volume: 113 Pages: 188-194
- DOI
  10.1016/j.fitote.2016.07.018
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16H04910, KAKENHI-PROJECT-15J04501, KAKENHI-PROJECT-16K07724, KAKENHI-PROJECT-16K16284
[Journal Article] Total synthesis of the proposed structure for aromin and its structural revision.2016
- Author(s)
  Takahashi S, Satoh D, Hayashi M, Takahashi K, Yamaguchi K, Nakamura T, Koshino H.
- Journal Title
  
  J Org Chem
  
  Volume: 81 Issue: 22 Pages: 11222-11234
- DOI
  10.1021/acs.joc.6b02187
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15K06848, KAKENHI-PROJECT-15K07421, KAKENHI-PROJECT-16K07724
[Journal Article] Structure of formitellan A, a mannofucogalactan from the fruiting Bodies of Fomitella fraxinea2011
- Author(s)
  S.-M.Cho, B.-S.Yun, I.D.Yoo, H.Koshino
- Journal Title
  
  Bioorg.Med.Chem.Lett.
  
  Volume: 21 Pages: 204-206
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20580118
[Journal Article] Simple and efficient synthesis of highly functionalized cyclohexanes ; formal total synthesis of ovalicin and fumagillin2011
- Author(s)
  Shunya Takahashi, Yayoi Hongo, Yue Qi Ye, Hiroyuki Koshino
- Journal Title
  
  Tetrahedron : Asymmetry 22
  
  Pages: 703-707
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20580118
[Journal Article] Formal total synthesis of aspergillide A2011
- Author(s)
  Yuko Izuchi, Nobuhiro Kanomata, Hiroyuki Koshino, Yayoi Hongo, Tadashi Nakata, Shunya Takahashi
- Journal Title
  
  Tetrahedron : Asymmetry 22
  
  Pages: 246-251
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20580118
[Journal Article] Formal total synthesis of aspergillide A2011
- Author(s)
  Y.Izuchi, N.Kanomata, H.Koshino, Y.Hongo, T.Nakata, S.Takahashi
- Journal Title
  
  Tetrahedron : Asymmetry
  
  Volume: 22(in press)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20580118
[Journal Article] A new sesquiterpenoid produced by female Callosobruchus rhodesianus (Pic) : a possible component of the sex attractant pheromone2010
- Author(s)
  Kenji Shimomura, Hiroyuki Koshino, Arata Yajima, Noriko Matsumoto, Shunsuke Yajima, Kanju Ohsawa
- Journal Title
  
  Tetrahedron Lett. 51
  
  Pages: 6860-6862
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20580118
[Journal Article] A new sesquitepenoid produced by female Callosobruchus rhodesianus (Pic) : a possible component of the sex attractant pheromone2010
- Author(s)
  K.Shimomura, H.Koshino, A.Yajima, N.Matsumoto, S.Yajima, K.Ohsawa
- Journal Title
  
  Tetrahedron Lett.
  
  Volume: 51 Pages: 6860-6862
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20580118
[Journal Article] Studies on natural p-terphenyls : Total syntheses of vialinin A and terrestrin B2010
- Author(s)
  Yue Qi Ye, Hiroyuki Koshino, Jun-ichi Onose, Kunie Yoshikawa, Naoki Abe, Shunya Takahashi
- Journal Title
  
  Biosci.Biotechnol.Biochem. 74
  
  Pages: 140-146
- NAID
  10027550390
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20580118
[Journal Article] Studies on natural p-terphenyls : total syntheses of vialinin A and terrestrin B2010
- Author(s)
  Y.Q.Ye, H.Koshino, J.Onose, K.Yoshikawa, N.Abe, S.Takahashi
- Journal Title
  
  Biosci.Biotechnol.Biochem. 74
  
  Pages: 140-146
- NAID
  10027550390
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20580118
[Journal Article] 2,3-Dihydrohomofarnesal : Female sex attractant pheromone component of Callosobruchus rhodesianus (Pic)2010
- Author(s)
  K.Shimomura, H.Koshino, A.Yajima, N.Matsumoto, Y.Kagohara, K.Kamada, S.Yajima, K.Ohsawa
- Journal Title
  
  J.Chem.Ecol.
  
  Volume: 36 Pages: 824-833
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20580118
[Journal Article] Synthesis of atromentin and its O-alklyated natural products2010
- Author(s)
  Yue Qi Ye, Hiroyuki Koshino, Naoki Abe, Shunya Takahashi
- Journal Title
  
  Biosci.Biotechnol.Biochem. 74
  
  Pages: 2342-2344
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20580118
[Journal Article] Synthesis of atromentin and its O-alkylated natural products2010
- Author(s)
  Y.Q.Ye, H.Koshino, N.Abe, T.Nakamura, D.Hashizume, S.Takahashi
- Journal Title
  
  Biosci.Biotechnol.Biochem.
  
  Volume: 74 Pages: 2342-2344
- NAID
  10027561974
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20580118
[Journal Article] Synthesis of all possible isomers corresponding to the proposed structure of montanacin E, and their antitumor activity2009
- Author(s)
  S.Takahashi, R.Takahashi, Y.Hongo, H.Koshino, K.Yamaguchi, T.Miyagi
- Journal Title
  
  J.Org.Chem. 74
  
  Pages: 6382-6385
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20580118
[Journal Article] Structural revision of thelephantin G by total synthesis and the inhibitory activity against TNF-α production2009
- Author(s)
  Y.Q.Ye, H.Koshino, J.Onose, C.Negishi, K.Yoshikawa, N.Abe, S.Takahashi
- Journal Title
  
  J.Org.Chem. 74
  
  Pages: 4642-4645
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20580118
[Journal Article] Structural revision od thelephantin G by total synthesis and the inhibitory activity against TNF-α production2009
- Author(s)
  Yue Qi Ye, Hiroyuki Koshino, Jun-ichi Onose, Chiemi Negishi, Kunie Yoshikawa, Naoki Abe, Shunya Takahashi
- Journal Title
  
  J.Org.Chem. 74
  
  Pages: 4642-4645
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20580118
[Journal Article] Expeditious synthesis of vialinin B, an extremely potent inhibitor of TNF-α production2009
- Author(s)
  Y.Q.Ye, H.Koshino, J.Onose, K.Yoshikawa, N.Abe, S.Takahashi
- Journal Title
  
  Org.Lett. 11
  
  Pages: 5074-5077
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20580118
[Journal Article] Expeditious synthesis of vialinin B, an extremely potent inhibitor of TNF-α production2009
- Author(s)
  Yue Qi Ye, Hiroyuki Koshino, Jun-ichi Onose, Kunie Yoshikawa, Naoki Abe, Shunya Takahashi
- Journal Title
  
  Org.Lett. 11
  
  Pages: 5074-5077
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20580118
[Journal Article] Synthesis of all possible isomers corresponding to the proposed structure of montanacin E, and their antitumor activity2009
- Author(s)
  Shunya Takahashi, Ryotaro Takahashi, Yayoi Hongo, Hiroyuki Koshino, Kazunori Yamaguchi, Taeko Miyagi
- Journal Title
  
  J.Org.Chem. 74
  
  Pages: 6382-6385
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20580118
[Journal Article] Structural determination of montanacin D by total synthesis2008
- Author(s)
  S. Takahashi, Y. Hongo, Y. Tsukagoshi, H. Koshino
- Journal Title
  
  Org. Lett. 10
  
  Pages: 4223-4226
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20580118
[Journal Article] Structure determination of montanacin D by total synthesis2008
- Author(s)
  Shunya Takahashi, Yayoi Hongo, Yuki Tsukagoshi, Hiroyuki Koshino
- Journal Title
  
  Org.Lett. 10
  
  Pages: 4223-4226
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20580118
[Journal Article] Synthesis and structural revision of phomopsin B, a novel polyketide carrying a 10-membered cyclic-ether ring
- Author(s)
  Yuko Izuchi, Hiroyuki Koshino, Yayoi Hongo, Nobuhiro Kanomata, Shunya Takahashi
- Journal Title
  
  Org.Lett. (in press)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20580118
[Presentation] スペイン産琥珀と久慈産琥珀の生物活性物質の構造と活性の比較研究2024
- Author(s)
  笹本啓将，鈴木瑞季，越野広雪，CESAR Menor-Salvan，木村賢一
- Organizer
  日本農芸化学会
- Data Source
  KAKENHI-PROJECT-21K05399
[Presentation] 酵母ユビキチンリガーゼRSP5変異株を用いた久慈産琥珀由来の生物活性物質の探索2024
- Author(s)
  丹場晴也，越野広雪，野川俊彦，今井央由，高木博史，木村賢一
- Organizer
  日本農芸化学会
- Data Source
  KAKENHI-PROJECT-21K05399
[Presentation] 遺伝子変異酵母株を用いた久慈産琥珀からの生物活性物質の単離精製と構造2023
- Author(s)
  池田はるな，越野広雪，鈴木瑞季，木村賢一
- Organizer
  日本農芸化学会東北支部大会
- Data Source
  KAKENHI-PROJECT-21K05399
[Presentation] RBL-2H3細胞の脱顆粒抑制活性を指標とした久慈産琥珀由来の生物活性物質の探索2023
- Author(s)
  田中来実，越野広雪，木村賢一
- Organizer
  第65回天然有機化合物討論会
- Data Source
  KAKENHI-PROJECT-21K05399
[Presentation] 遺伝子変異酵母株の生育回復活性を用いた中国産琥珀に含まれる生物活性物質の単離精製と同定2022
- Author(s)
  Lethi NgocAnh，松本千里，高木博史，野川俊彦，越野広雪，木村賢一
- Organizer
  2023年日本農芸化学会（広島・Web開催）
- Data Source
  KAKENHI-PROJECT-21K05399
[Presentation] 岩手県久慈市で産出される琥珀とジェットの生物活性と活性物質の比較分析2022
- Author(s)
  笹本啓将，松本千里，越野広雪，木村賢一
- Organizer
  2023年日本農芸化学会（広島・Web開催）
- Data Source
  KAKENHI-PROJECT-21K05399
[Presentation] 酵母ユビキチンリガーゼRSP5変異株を高温ストレス下で生育を回復させる久慈産琥珀由来の生物活性物質の探索2022
- Author(s)
  丹場晴也，田中来実，高木博史，越野広雪，木村賢一
- Organizer
  2022年日本農芸化学会, 3F02-03.
- Data Source
  KAKENHI-PROJECT-21K05399
[Presentation] 酵母のユビキチンリガーゼRsp5変異酵母株を用いた久慈産琥珀由来の生物活性物質の探索2022
- Author(s)
  丹場晴也，田中来実，高木博史，越野広雪，木村賢一
- Organizer
  天然有機化合物討論会
- Data Source
  KAKENHI-PROJECT-21K05399
[Presentation] マダガスカル産コーパル由来の生物活性物質の単離精製、構造解析ならびに生物活性2022
- Author(s)
  田端菜々海, 松本千里, 田中来実, 笹本啓将, 丹場晴也, 古山達貴, 越野広雪, 木村賢一
- Organizer
  日本農芸化学会北海道支部・東北支部合同大会
- Data Source
  KAKENHI-PROJECT-21K05399
[Presentation] 久慈産琥珀抽出物の不思議な生物活性の謎に迫る2021
- Author(s)
  田中来実, 及川和吉, 越野広雪，白井誠之，木村賢一
- Organizer
  日本生化学会東北支部　第87回例会・シンポジウム，5月29日（土）, p83
- Data Source
  KAKENHI-PROJECT-21K05399
[Presentation] The relationship between PPM1A activation activity and the inhibition activity of degranulation in RBL-2H3 cells.2021
- Author(s)
  Y. Miura, Y. Kudo, H. Koshino, T. Kataoka, M. Ohnishi, K. Kimura
- Organizer
  Pacifichem 2021, Dec. 17-21, 3440337.
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K05399
[Presentation] Elucidation of biologically active compounds from an insoluble fraction of Kuji amber.2021
- Author(s)
  J. Abe, H. Koshino, K. Oikawa, Y. Miura, S. Uesugi, M. Shirai, K. Kimura
- Organizer
  Pacifichem 2021, Dec. 17-21, 3440311.
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K05399
[Presentation] 久慈産琥珀超臨界メタノール分解・抽出物からの抗アレルギー活性物質の探索2021
- Author(s)
  田中来実，阿部純平，及川和吉，越野広雪，白井誠之，木村賢一
- Organizer
  日本農芸化学会東北支部第156回大会，10月9日（土），A13，p17.
- Data Source
  KAKENHI-PROJECT-21K05399
[Presentation] New inhibitors of melanin production in B16 mouse melanoma cells from the methanol extract of Kuji amber.2021
- Author(s)
  J. Abe, S. Suzuki, S. Takahashi, H. Koshino, K. Kimura
- Organizer
  Pacifichem 2021, Dec. 17-21, 3440283.
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K05399
[Presentation] 13C NMR化学シフト予測・部分構造検索機能を有すうるCAST/CNMRシステムの公開2018
- Author(s)
  越野広雪、朝倉克夫、栗本智充、小市俊悟、佐藤寛子
- Organizer
  第57回NMR討論会
- Data Source
  KAKENHI-PROJECT-16K07724
[Presentation] 13C NMR化学シフト予測・部分構造検索機能を構造検索機能を有するCAST/CNMRシステムの高分子への応用の検討2018
- Author(s)
  越野広雪、小市俊悟、佐藤寛子
- Organizer
  第23回高分子分析討論会
- Data Source
  KAKENHI-PROJECT-16K07724
[Presentation] Structural Revision of Terpenoids and Related Natural Products by Using CAST/CNMR System2018
- Author(s)
  Koshino Hiroyuki, Koichi Shungo, Satoh Hiroko
- Organizer
  EUROMAR2018
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K07724
[Presentation] CAST/CNMRシステムを用いたプレニル化されたフェノール類の構造訂正2017
- Author(s)
  越野広雪、小市俊悟、佐藤寛子
- Organizer
  第61回香料・テルペンおよび精油化学に関する討論会
- Data Source
  KAKENHI-PROJECT-16K07724
[Presentation] CAST/CNMRシステムを用いたClerodane型ジテルペンの13C NMRの貴族と構造の評価2017
- Author(s)
  越野広雪、栗澤尚瑛、木村賢一、小市俊悟、佐藤寛子
- Organizer
  第56回NMR討論会
- Data Source
  KAKENHI-PROJECT-16K07724
[Presentation] 論文記載の構造解析の評価-構造訂正を中心に2016
- Author(s)
  越野広雪
- Organizer
  理研シンポジウム分子構造解析2016:MSとNMRの基礎と実践
- Place of Presentation
  理化学研究所鈴木梅太郎記念ホール（埼玉県和光市）
- Year and Date
  2016-06-17
- Data Source
  KAKENHI-PROJECT-16K07724
[Presentation] CAST/CNMRシステムを用いたcis-デカリン骨格を有するテルペノイドの立体化学の評価2016
- Author(s)
  越野広雪、小市俊悟、佐藤寛子
- Organizer
  第60回香料・テルペンおよび精油化学に関する討論会
- Place of Presentation
  東京農業大学オホーツクキャンパス（北海道網走市）
- Year and Date
  2016-10-29
- Data Source
  KAKENHI-PROJECT-16K07724
[Presentation] Structural revision of pyrone-related natural products by using CAST/CNMR system2016
- Author(s)
  Koshino H., Koichi S., Satoh H.
- Organizer
  EUROMAR2016
- Place of Presentation
  Aarhus, Denmark
- Year and Date
  2016-07-04
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K07724
[Presentation] CAST/CNMRシステムを用いた13C NMRシフト値による様々な有機化合物の構造訂正2016
- Author(s)
  越野広雪、小市俊悟、佐藤寛子
- Organizer
  第55回NMR討論会
- Place of Presentation
  広島国際会議場　(広島県広島市中区)
- Year and Date
  2016-11-16
- Data Source
  KAKENHI-PROJECT-16K07724
[Presentation] NMRによる構造解析法の開発と構造訂正における合成の重要性2010
- Author(s)
  越野広雪
- Organizer
  藪田セミナー「天然物有機化合物を起点とした化学生物学の新展開」
- Place of Presentation
  札幌
- Year and Date
  2010-06-18
- Data Source
  KAKENHI-PROJECT-20580118
[Presentation] CAST/CNMRシステムの構造訂正への応用(第4報)2010
- Author(s)
  越野広雪、叶躍奇、高橋俊哉、佐藤寛子
- Organizer
  日本農芸化学会2010年度大会
- Place of Presentation
  (東京大学)東京
- Year and Date
  2010-03-28
- Data Source
  KAKENHI-PROJECT-20580118
[Presentation] CAST/CNMRの構造訂正への応用(第4報)2010
- Author(s)
  越野広雪,高橋俊哉,佐藤寛子
- Organizer
  日本農芸化学会2010年度大会
- Place of Presentation
  東京
- Year and Date
  2010-03-28
- Data Source
  KAKENHI-PROJECT-20580118
[Presentation] CAST/CNMRシステムの構造訂正への応用(第3報)2009
- Author(s)
  越野広雪, 高橋俊哉, 佐藤寛子
- Organizer
  日本農芸化学会2009年度大会
- Place of Presentation
  福岡
- Data Source
  KAKENHI-PROJECT-20580118
[Presentation] CAST/CNMRシステムと合成による天然有機化合物の構造訂正2009
- Author(s)
  越野広雪,叶躍奇,高橋俊哉,佐藤寛子
- Organizer
  第48回NMR討論会
- Place of Presentation
  福岡
- Year and Date
  2009-11-10
- Data Source
  KAKENHI-PROJECT-20580118
[Presentation] CAST/CNMRの構造訂正への応用(第3報)2009
- Author(s)
  越野広雪,高橋俊哉,佐藤寛子
- Organizer
  日本農芸化学会2009年度大会
- Place of Presentation
  福岡
- Year and Date
  2009-03-28
- Data Source
  KAKENHI-PROJECT-20580118
[Presentation] CAST/CNMRシステムと合成による天然有機化合物の構造訂正2009
- Author(s)
  越野広雪、叶躍奇、高橋俊哉、佐藤寛子
- Organizer
  第48回NMR討論会
- Place of Presentation
  (九州大学)福岡
- Year and Date
  2009-11-10
- Data Source
  KAKENHI-PROJECT-20580118

1. KIMURA Ken-ichi (30344625)

# of Collaborated Projects: 2 results

# of Collaborated Products: 16 results
2. 佐藤寛子 (50291068)

# of Collaborated Projects: 2 results

# of Collaborated Products: 8 results
3. RYOHEI Yamasaki (80273887)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
4. TSUYOSHI Sanekata (20205991)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
5. KEN Nouda (60218287)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. JUNICHI Tamura (30221401)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. 黒野定 (20271554)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. 吉田潤 (20611007)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. 伊藤芳明 (50312517)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. Koichi Shungo

# of Collaborated Projects: 1 results

# of Collaborated Products: 8 results
11. Takahashi Shunya

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
12. OHSATO Shuichi

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
13. YAMAGUCHI Kazunori

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
14. MINAMI Atsushi

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
15. 西内巧

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
16. 橋本勝

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
17. 田中和明

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Koshino Hiroyuki 越野 広雪

越野 広雪 コシノ ヒロユキ

KOSHINO Hiroyuki 越野 広雪

HIROYUKI Koshino 越野 広雪

Research Projects

Research Products

Co-Researchers

Integrated study on amber's unique chemical space and diverse biological activities

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Integrated analysis of chemical reaction products in Cretaceous amber and their biological activity

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Evaluation of structure detemination of natural products by using 13C NMR chemical shifts and study of structural revisionPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

A new method for analysis of stereochemistry in carbonyl containing compounds using chemical shifts and spin coupling constant valuesPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

立体化学と考慮した^<13>C-NMR化学シフト予測システム開発と立体配置決定への応用Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Development of pseudo-LOS vaccines

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Isolation of a spirolactone norditerpenoid as a yeast Ca^2+ signal transduction inhibitor from Kuji amber and evaluation of its effects on PPM1A activity2019

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Isolation of yeast Ca2+ signal transduction inhibitors from the Early Cretaceous Burmese amber2019

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Isolation of Peribysins O, P, and Q from Periconia macrospinosa KT3863, and Configurational Reinvestigation of Peribysin E Diacetate from Periconia byssoides OUPS-N1332019

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Biosynthetic study of conidiation-inducing factor conidiogenone: Heterologous production and cyclization mechanism of a key bifunctional diterpene synthase2019

Author(s)

Journal Title

DOI

Data Source

[Journal Article] The value of universally available raw NMR data for transparency, reproducibility, and integrity in natural product research2019

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Convenient Synthesis of Thiohydantoins, Imidazole-2-thiones and Imidazo[2,1-b]thiazol-4-iums from Polymer-Supported α-Acylamino Ketones2018

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Amberene and 1-methylamberene, isolated and identified from Kuji amber (Japan)2018

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Synthesis of polyozellin, a prolyl oligopeptidase inhibitor, and its structural revision2018

Author(s)

Koshino Hiroyuki 越野広雪

越野広雪コシノヒロユキ

KOSHINO Hiroyuki 越野広雪

HIROYUKI Koshino 越野広雪