KOSHINO Hiroyuki 越野広雪

Researcher Number	50321758
Other IDs
Affiliation *help	2018 : 国立研究開発法人理化学研究所, 開拓研究本部, 副主任研究員 2016 – 2017 : 国立研究開発法人理化学研究所, 環境資源科学研究センター, ユニットリーダー 2008 – 2010 : The Institute of Physical and Chemical Research, 物質構造解析チーム, チームヘッド 2002 : 理化学研究所, 分子構造解析室, 室長(副主任研究員待遇) 2001 : 理化学研究所, 分子構造解析室, 室長(研究職) … More
Review Section/Research Field	Principal Investigator Bioorganic chemistry / Bioproduction chemistry/Bioorganic chemistry / Science and Engineering Except Principal Investigator Applied molecular and cellular biology
Keywords	Principal Investigator 立体化学 / 核磁気共鳴 / 構造訂正 / ピロン / フォモプシンB / スピン結合定数 / ロンギフォレン / テレファンチンG / テルペノイド / INADEQUATE法 … More Except Principal Investigator Oligosaccharide / LPS / Neisseria gonorrhoeae / Vaccine / 免役化学 / Lipooligosaccharide (LOS / りん菌 / オリゴ糖 / リポ多糖 / Lipooligosacharide(LOS)c / ワクチン / LOS / 構造解析 / 免疫化学 / エピトープ Less

13C-NMR化学シフト値を用いる天然有機化合物の構造解析の評価と構造訂正研究Principal InvestigatorOngoing
- Principal Investigator
  
  越野広雪
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Bioorganic chemistry
- Research Institution
  Institute of Physical and Chemical Research
A new method for analysis of stereochemistry in carbonyl containing compounds using chemical shifts and spin coupling constant valuesPrincipal Investigator
- Principal Investigator
  
  KOSHINO Hiroyuki
- Project Period (FY)
  2008 – 2010
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Bioproduction chemistry/Bioorganic chemistry
- Research Institution
  The Institute of Physical and Chemical Research
立体化学と考慮した^<13>C-NMR化学シフト予測システム開発と立体配置決定への応用Principal Investigator
- Principal Investigator
  
  越野広雪
- Project Period (FY)
  2001 – 2002
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Science and Engineering
- Research Institution
  The Institute of Physical and Chemical Research
Development of pseudo-LOS vaccines
- Principal Investigator
  
  RYOHEI Yamasaki
- Project Period (FY)
  1998 – 2000
- Research Category
  
  Grant-in-Aid for Scientific Research (A).
- Research Field
  
  Applied molecular and cellular biology
- Research Institution
  TOTTORI UNIVERSITY

All 2016 2011 2010 2009 2008 Other

All Journal Article Presentation

[Journal Article] Total Synthesis of the Proposed Structure for Aromin and its Structural Revision2016
- Author(s)
  Takahashi S, Satoh D, Hayashi M, Takahashi K, Yamaguchi K, Nakamura T, Koshino H.
- Journal Title
  
  J. Org. Chem.
  
  Volume : 81 Pages : 11222-11234
- DOI
  10.1021/acs.joc.6b02187
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-15K06848, KAKENHI-PROJECT-15K07421, KAKENHI-PROJECT-16K07724
[Journal Article] Hydroxylations of trichothecene rings in the biosynthesis of Fusarium trichothecenes: evolution of alternative pathways in the nivalenol chemotype2016
- Author(s)
  Maeda K, Tanaka A, Sugiura R, Koshino H, Tokai T, Sato M, Nakajima Y, Tanahashi Y, Kanamaru K, Kobayashi T, Nishiuchi T, Fujimura M, Takahashi-Ando N, Kimura M.
- Journal Title
  
  Enviromental Microbiology
  
  Volume : 18 Pages : 3798-3811
- DOI
  10.1111/1462-2920.13338
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-26450053, KAKENHI-PROJECT-16K07724
[Journal Article] Isolation of coralmycins A and B, potent anti-Gram negative compounds from the Myxobacteria Corallococcus coralloides M232016
- Author(s)
  Kim Y. J., Kim H-J., Kim G-W., Cho K., Takahashi S., Koshino H., Kim W-G.
- Journal Title
  
  J. Nat. Prod.
  
  Volume : 79 Pages : 2223-2228
- DOI
  10.1021/acs.jnatprod.6b00294
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K07421, KAKENHI-PROJECT-16K07724
[Journal Article] Yeast Ca2+-signal transduction inhibitors isolated from Dominican amber prevent the degranulation of RBL-2H3 cells through the inhibition of Ca2+-influx.2016
- Author(s)
  Tomomi Abe, Miki Kobayashi, Yusuke Okawa, Tomoki Inui, Jun Yoshida, Hironori Higashio, Hisao Shinden, Shota Uesugi, Hiroyuki Koshino, Ken-ichi Kimura
- Journal Title
  
  Fitoterepia
  
  Volume : 113 Pages : 188-194
- DOI
  10.1016/j.fitote.2016.07.018
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16H04910, KAKENHI-PROJECT-15J04501, KAKENHI-PROJECT-16K07724, KAKENHI-PROJECT-16K16284
[Journal Article] Simple and efficient synthesis of highly functionalized cyclohexanes ; formal total synthesis of ovalicin and fumagillin2011
- Author(s)
  Shunya Takahashi, Yayoi Hongo, Yue Qi Ye, Hiroyuki Koshino
- Journal Title
  
  Tetrahedron : Asymmetry 22
  
  Pages : 703-707
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20580118
[Journal Article] Formal total synthesis of aspergillide A2011
- Author(s)
  Yuko Izuchi, Nobuhiro Kanomata, Hiroyuki Koshino, Yayoi Hongo, Tadashi Nakata, Shunya Takahashi
- Journal Title
  
  Tetrahedron : Asymmetry 22
  
  Pages : 246-251
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20580118
[Journal Article] Formal total synthesis of aspergillide A2011
- Author(s)
  Y.Izuchi, N.Kanomata, H.Koshino, Y.Hongo, T.Nakata, S.Takahashi
- Journal Title
  
  Tetrahedron : Asymmetry
  
  Volume : 22(in press)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20580118
[Journal Article] Structure of formitellan A, a mannofucogalactan from the fruiting Bodies of Fomitella fraxinea2011
- Author(s)
  S.-M.Cho, B.-S.Yun, I.D.Yoo, H.Koshino
- Journal Title
  
  Bioorg.Med.Chem.Lett.
  
  Volume : 21 Pages : 204-206
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20580118
[Journal Article] Studies on natural p-terphenyls : total syntheses of vialinin A and terrestrin B2010
- Author(s)
  Y.Q.Ye, H.Koshino, J.Onose, K.Yoshikawa, N.Abe, S.Takahashi
- Journal Title
  
  Biosci.Biotechnol.Biochem. 74
  
  Pages : 140-146
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20580118
[Journal Article] Synthesis of atromentin and its O-alklyated natural products2010
- Author(s)
  Yue Qi Ye, Hiroyuki Koshino, Naoki Abe, Shunya Takahashi
- Journal Title
  
  Biosci.Biotechnol.Biochem. 74
  
  Pages : 2342-2344
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20580118
[Journal Article] Studies on natural p-terphenyls : Total syntheses of vialinin A and terrestrin B2010
- Author(s)
  Yue Qi Ye, Hiroyuki Koshino, Jun-ichi Onose, Kunie Yoshikawa, Naoki Abe, Shunya Takahashi
- Journal Title
  
  Biosci.Biotechnol.Biochem. 74
  
  Pages : 140-146
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20580118
[Journal Article] A new sesquiterpenoid produced by female Callosobruchus rhodesianus (Pic) : a possible component of the sex attractant pheromone2010
- Author(s)
  Kenji Shimomura, Hiroyuki Koshino, Arata Yajima, Noriko Matsumoto, Shunsuke Yajima, Kanju Ohsawa
- Journal Title
  
  Tetrahedron Lett. 51
  
  Pages : 6860-6862
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20580118
[Journal Article] Synthesis of atromentin and its O-alkylated natural products2010
- Author(s)
  Y.Q.Ye, H.Koshino, N.Abe, T.Nakamura, D.Hashizume, S.Takahashi
- Journal Title
  
  Biosci.Biotechnol.Biochem.
  
  Volume : 74 Pages : 2342-2344
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20580118
[Journal Article] A new sesquitepenoid produced by female Callosobruchus rhodesianus (Pic) : a possible component of the sex attractant pheromone2010
- Author(s)
  K.Shimomura, H.Koshino, A.Yajima, N.Matsumoto, S.Yajima, K.Ohsawa
- Journal Title
  
  Tetrahedron Lett.
  
  Volume : 51 Pages : 6860-6862
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20580118
[Journal Article] 2,3-Dihydrohomofarnesal : Female sex attractant pheromone component of Callosobruchus rhodesianus (Pic)2010
- Author(s)
  K.Shimomura, H.Koshino, A.Yajima, N.Matsumoto, Y.Kagohara, K.Kamada, S.Yajima, K.Ohsawa
- Journal Title
  
  J.Chem.Ecol.
  
  Volume : 36 Pages : 824-833
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20580118
[Journal Article] Synthesis of all possible isomers corresponding to the proposed structure of montanacin E, and their antitumor activity2009
- Author(s)
  S.Takahashi, R.Takahashi, Y.Hongo, H.Koshino, K.Yamaguchi, T.Miyagi
- Journal Title
  
  J.Org.Chem. 74
  
  Pages : 6382-6385
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20580118
[Journal Article] Structural revision of thelephantin G by total synthesis and the inhibitory activity against TNF-α production2009
- Author(s)
  Y.Q.Ye, H.Koshino, J.Onose, C.Negishi, K.Yoshikawa, N.Abe, S.Takahashi
- Journal Title
  
  J.Org.Chem. 74
  
  Pages : 4642-4645
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20580118
[Journal Article] Expeditious synthesis of vialinin B, an extremely potent inhibitor of TNF-α production2009
- Author(s)
  Y.Q.Ye, H.Koshino, J.Onose, K.Yoshikawa, N.Abe, S.Takahashi
- Journal Title
  
  Org.Lett. 11
  
  Pages : 5074-5077
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20580118
[Journal Article] Structural revision od thelephantin G by total synthesis and the inhibitory activity against TNF-α production2009
- Author(s)
  Yue Qi Ye, Hiroyuki Koshino, Jun-ichi Onose, Chiemi Negishi, Kunie Yoshikawa, Naoki Abe, Shunya Takahashi
- Journal Title
  
  J.Org.Chem. 74
  
  Pages : 4642-4645
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20580118
[Journal Article] Expeditious synthesis of vialinin B, an extremely potent inhibitor of TNF-α production2009
- Author(s)
  Yue Qi Ye, Hiroyuki Koshino, Jun-ichi Onose, Kunie Yoshikawa, Naoki Abe, Shunya Takahashi
- Journal Title
  
  Org.Lett. 11
  
  Pages : 5074-5077
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20580118
[Journal Article] Synthesis of all possible isomers corresponding to the proposed structure of montanacin E, and their antitumor activity2009
- Author(s)
  Shunya Takahashi, Ryotaro Takahashi, Yayoi Hongo, Hiroyuki Koshino, Kazunori Yamaguchi, Taeko Miyagi
- Journal Title
  
  J.Org.Chem. 74
  
  Pages : 6382-6385
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20580118
[Journal Article] Structural determination of montanacin D by total synthesis2008
- Author(s)
  S. Takahashi, Y. Hongo, Y. Tsukagoshi, H. Koshino
- Journal Title
  
  Org. Lett. 10
  
  Pages : 4223-4226
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20580118
[Journal Article] Structure determination of montanacin D by total synthesis2008
- Author(s)
  Shunya Takahashi, Yayoi Hongo, Yuki Tsukagoshi, Hiroyuki Koshino
- Journal Title
  
  Org.Lett. 10
  
  Pages : 4223-4226
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20580118
[Journal Article] Synthesis and structural revision of phomopsin B, a novel polyketide carrying a 10-membered cyclic-ether ring
- Author(s)
  Yuko Izuchi, Hiroyuki Koshino, Yayoi Hongo, Nobuhiro Kanomata, Shunya Takahashi
- Journal Title
  
  Org.Lett. (in press)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20580118
[Presentation] 論文記載の構造解析の評価-構造訂正を中心に2016
- Author(s)
  越野広雪
- Organizer
  理研シンポジウム分子構造解析2016:MSとNMRの基礎と実践
- Place of Presentation
  理化学研究所鈴木梅太郎記念ホール（埼玉県和光市）
- Year and Date
  2016-06-17
- Data Source
  KAKENHI-PROJECT-16K07724
[Presentation] CAST/CNMRシステムを用いたcis-デカリン骨格を有するテルペノイドの立体化学の評価2016
- Author(s)
  越野広雪、小市俊悟、佐藤寛子
- Organizer
  第60回香料・テルペンおよび精油化学に関する討論会
- Place of Presentation
  東京農業大学オホーツクキャンパス（北海道網走市）
- Year and Date
  2016-10-29
- Data Source
  KAKENHI-PROJECT-16K07724
[Presentation] CAST/CNMRシステムを用いた13C NMRシフト値による様々な有機化合物の構造訂正2016
- Author(s)
  越野広雪、小市俊悟、佐藤寛子
- Organizer
  第55回NMR討論会
- Place of Presentation
  広島国際会議場　(広島県広島市中区)
- Year and Date
  2016-11-16
- Data Source
  KAKENHI-PROJECT-16K07724
[Presentation] Structural revision of pyrone-related natural products by using CAST/CNMR system2016
- Author(s)
  Koshino H., Koichi S., Satoh H.
- Organizer
  EUROMAR2016
- Place of Presentation
  Aarhus, Denmark
- Year and Date
  2016-07-04
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K07724
[Presentation] NMRによる構造解析法の開発と構造訂正における合成の重要性2010
- Author(s)
  越野広雪
- Organizer
  藪田セミナー「天然物有機化合物を起点とした化学生物学の新展開」
- Place of Presentation
  札幌
- Year and Date
  2010-06-18
- Data Source
  KAKENHI-PROJECT-20580118
[Presentation] CAST/CNMRの構造訂正への応用(第4報)2010
- Author(s)
  越野広雪,高橋俊哉,佐藤寛子
- Organizer
  日本農芸化学会2010年度大会
- Place of Presentation
  東京
- Year and Date
  2010-03-28
- Data Source
  KAKENHI-PROJECT-20580118
[Presentation] NMRによる構造解析法の開発と構造訂正における合成の重要性2010
- Author(s)
  越野広雪
- Organizer
  藪田セミナー「天然物有機化合物を起点とした化学生物学の新展開」
- Place of Presentation
  札幌
- Year and Date
  2010-06-18
- Data Source
  KAKENHI-PROJECT-20580118
[Presentation] CAST/CNMRシステムの構造訂正への応用(第4報)2010
- Author(s)
  越野広雪、叶躍奇、高橋俊哉、佐藤寛子
- Organizer
  日本農芸化学会2010年度大会
- Place of Presentation
  (東京大学)東京
- Year and Date
  2010-03-28
- Data Source
  KAKENHI-PROJECT-20580118
[Presentation] CAST/CNMRシステムの構造訂正への応用(第3報)2009
- Author(s)
  越野広雪, 高橋俊哉, 佐藤寛子
- Organizer
  日本農芸化学会2009年度大会
- Place of Presentation
  福岡
- Data Source
  KAKENHI-PROJECT-20580118
[Presentation] CAST/CNMRシステムと合成による天然有機化合物の構造訂正2009
- Author(s)
  越野広雪,叶躍奇,高橋俊哉,佐藤寛子
- Organizer
  第48回NMR討論会
- Place of Presentation
  福岡
- Year and Date
  2009-11-10
- Data Source
  KAKENHI-PROJECT-20580118
[Presentation] CAST/CNMRの構造訂正への応用(第3報)2009
- Author(s)
  越野広雪,高橋俊哉,佐藤寛子
- Organizer
  日本農芸化学会2009年度大会
- Place of Presentation
  福岡
- Year and Date
  2009-03-28
- Data Source
  KAKENHI-PROJECT-20580118
[Presentation] CAST/CNMRシステムと合成による天然有機化合物の構造訂正2009
- Author(s)
  越野広雪、叶躍奇、高橋俊哉、佐藤寛子
- Organizer
  第48回NMR討論会
- Place of Presentation
  (九州大学)福岡
- Year and Date
  2009-11-10
- Data Source
  KAKENHI-PROJECT-20580118

1. RYOHEI Yamasaki (80273887)

# of Collaborated Projects : 1results

# of Collaborated Products : 0results
2. TSUYOSHI Sanekata (20205991)

# of Collaborated Projects : 1results

# of Collaborated Products : 0results
3. KEN Nouda (60218287)

# of Collaborated Projects : 1results

# of Collaborated Products : 0results
4. JUNICHI Tamura (30221401)

# of Collaborated Projects : 1results

# of Collaborated Products : 0results
5. 佐藤寛子 (50291068)

# of Collaborated Projects : 1results

# of Collaborated Products : 0results
6. 黒野定 (20271554)

# of Collaborated Projects : 1results

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7. 山口壹範

# of Collaborated Projects : 0results

# of Collaborated Products : 1results
8. 高橋俊哉

# of Collaborated Projects : 0results

# of Collaborated Products : 2results
9. 西内巧

# of Collaborated Projects : 0results

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10. 木村賢一

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11. 吉田潤

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# of Collaborated Products : 1results

KOSHINO Hiroyuki 越野 広雪

Research Projects

Research Products

Co-Researchers

13C-NMR化学シフト値を用いる天然有機化合物の構造解析の評価と構造訂正研究Principal InvestigatorOngoing

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

A new method for analysis of stereochemistry in carbonyl containing compounds using chemical shifts and spin coupling constant valuesPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

立体化学と考慮した^<13>C-NMR化学シフト予測システム開発と立体配置決定への応用Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Development of pseudo-LOS vaccines

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Total Synthesis of the Proposed Structure for Aromin and its Structural Revision2016

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Hydroxylations of trichothecene rings in the biosynthesis of Fusarium trichothecenes: evolution of alternative pathways in the nivalenol chemotype2016

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Isolation of coralmycins A and B, potent anti-Gram negative compounds from the Myxobacteria Corallococcus coralloides M232016

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Yeast Ca2+-signal transduction inhibitors isolated from Dominican amber prevent the degranulation of RBL-2H3 cells through the inhibition of Ca2+-influx.2016

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Simple and efficient synthesis of highly functionalized cyclohexanes ; formal total synthesis of ovalicin and fumagillin2011

Author(s)

Journal Title

Data Source

[Journal Article] Formal total synthesis of aspergillide A2011

Author(s)

Journal Title

Data Source

[Journal Article] Formal total synthesis of aspergillide A2011

Author(s)

Journal Title

Data Source

[Journal Article] Structure of formitellan A, a mannofucogalactan from the fruiting Bodies of Fomitella fraxinea2011

Author(s)

Journal Title

Data Source

[Journal Article] Studies on natural p-terphenyls : total syntheses of vialinin A and terrestrin B2010

Author(s)

Journal Title

Data Source

[Journal Article] Synthesis of atromentin and its O-alklyated natural products2010

Author(s)

Journal Title

Data Source

[Journal Article] Studies on natural p-terphenyls : Total syntheses of vialinin A and terrestrin B2010

Author(s)

Journal Title

Data Source

[Journal Article] A new sesquiterpenoid produced by female Callosobruchus rhodesianus (Pic) : a possible component of the sex attractant pheromone2010

Author(s)

Journal Title

Data Source

KOSHINO Hiroyuki 越野広雪