YAMASHITA Hiroshi 山下尋史

Researcher Number	50323572
Affiliation (based on the past Project Information) *help	2005 – 2013: 東京大学, 医学部附属病院, 講師 2007 – 2008: The University of Tokyo, Graduate School of Frontier Sciences, Lecturer 2002 – 2004: University of Tokyo, Graduate School of Medicine, Reseach Associate, 医学部附属病院, 助手 2003: University of Tokyo, Department of Medicine, Instructor, 医学部, 助手 2002: 帝京大学, 医学部, 教授 2001: Dept. Med., Univ. Tokyo., Instructer, 医学部, 助手 2000 – 2001: University of Tokyo, Facuulty of Medicine Assistant, 医学部・附属病院, 助手
Review Section/Research Field	Principal Investigator Metabolomics / Circulatory organs internal medicine / Circulatory organs internal medicine Except Principal Investigator Biomedical engineering/Biological material science / Circulatory organs internal medicine / General physiology / Circulatory organs internal medicine
Keywords	Principal Investigator in vitro motility assay / subfragment-2 / メタボリックシンドローム / 生体分子イメージング / 共焦点顕微鏡 / 慢性炎症 / メタボリック症候群 / 分子イメージング / 脂肪組織 / リモデリング … More / 肥満 / 心筋ミオシン / ミオシン / カーボンファイバー / レーザートラップ / In vitro motility assay / Subfragment-2 / unitary displacement / unitary force / baculovirus / 免疫 / CD8陽性T細胞 / 内臓肥満 / 生体内分子イメージング / 血管新生 / 脂肪細胞 / VEGF / T細胞 / 炎症細胞 / 制御性B細胞 / インターロイキン１０ / 免疫異常 / 糖尿病 / ミオシン軽鎖 / インビトロ再構成系 / 筋収縮 / 分子生物学 / カルシウムイオン / アデノウイルス / 心筋 / cardiac myosin / myosin light chain / ミオシン軽鎖リン酸化 / ミオシン軽鎖リン酸化酵素 / アクチン活性化ATPase活性 / テロキン / ミオシン軽鎖アイソフォーム / ミオシン連鎖リン酸化 / 細胞内カルシウム濃度 / 単離心筋細胞 / Cardiac myosin / Myosin light chain kinase / Myosin light chain phosphorylation / Laser trap / Actin-activated ATPase activity / Telokin / in vitro motility assy / ATPase活性 / myosin / laser trap … More Except Principal Investigator 心筋細胞 / 拡張型心筋症 / in vitro motility assay / 心臓 / ミオシンアイソフォーム / Ca^<2+>過渡現象 / ATP / 機械刺激 / 微小操作 / 微小計測 / 細胞シミュレーション / アクチン / ミオシン軽鎖 / インビトロアッセイ / Actin / myosin light chain / 単一心筋細胞 / 適応現象 / 心室筋 / 過負荷 / heart / single myocyte / myoshin isoform / adaptation / Ca^<2+> transients / 収縮力 / カーボンファイバー / cardiac myocyte / contractile force / carbon fiber / 心室筋細胞 / 筋収縮 / レーザーオプティカルトラップ法 / レーザーオプティカルとラップ / Heart / Ventricular myocyte / Myosin isoform / Muscle contraction / Laser optical trap / 機械-電気帰還現象 / 電気生理モデル / 不整脈 / 循環器・高血圧 / 生理学 / シミュレーション工学 / mechano-electrical feedback / cardiomyocyte / electrophysiological model / arrhythmia Less

Investigation in the pathogenesis of metabolic syndrome with in vivo molecular imagingPrincipal Investigator
- Principal Investigator
  
  YAMASHITA Hiroshi
- Project Period (FY)
  2011 – 2013
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Metabolomics
- Research Institution
  The University of Tokyo
Multi-scale simulation model of cardiomyocyte based on the micromechanical measurement of subcellular structure
- Principal Investigator
  
  SUGIURA Seiryo
- Project Period (FY)
  2008 – 2010
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Biomedical engineering/Biological material science
- Research Institution
  The University of Tokyo
In vivo molecular imaging analysis of pathophysiology in metabolic syndromePrincipal Investigator
- Principal Investigator
  
  YAMASHITA Hiroshi
- Project Period (FY)
  2008 – 2010
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Metabolomics
- Research Institution
  The University of Tokyo
力伝達障害としての拡張型心筋症の病態メカニズムの解明
- Principal Investigator
  
  SUGIURA Seiryo
- Project Period (FY)
  2007 – 2008
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  Circulatory organs internal medicine
- Research Institution
  The University of Tokyo
Aphysiomic approach to evaluate the role of mechano-electrical feedback in arrhythmia
- Principal Investigator
  
  SUGIURA Seiryo
- Project Period (FY)
  2006 – 2007
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Biomedical engineering/Biological material science
- Research Institution
  The University of Tokyo
Investigation on the functional significance of myosin subfragment-2Principal Investigator
- Principal Investigator
  
  YAMASHITA Hiroshi
- Project Period (FY)
  2005 – 2006
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Circulatory organs internal medicine
- Research Institution
  The University of Tokyo
Investigation on the functional significance of myosin light chain kinase and myosin light chain phosphorylationPrincipal Investigator
- Principal Investigator
  
  YAMASHITA Hiroshi
- Project Period (FY)
  2003 – 2004
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Circulatory organs internal medicine
- Research Institution
  The University of Tokyo
Development of myosin isoform function in single ventricular myocytesHeart
- Principal Investigator
  
  SUGI Haruo
- Project Period (FY)
  2002 – 2003
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  General physiology
- Research Institution
  Teikyo University
Development of novel therapeutic options for treating heart failure targeting the myosin light chainPrincipal Investigator
- Principal Investigator
  
  YAMASHITA Hiroshi
- Project Period (FY)
  2001 – 2002
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Circulatory organs internal medicine
- Research Institution
  The University of Tokyo
Development of a Gene Transfer and Functional Evaluation System for an Isolated Single Cardiac Myocyte as a model for the Gene Therapy
- Principal Investigator
  
  SUGIURA Seiryo
- Project Period (FY)
  2001 – 2002
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Circulatory organs internal medicine
- Research Institution
  The University of Tokyo
Molecular mechanism of adaptation in human ventricular myosin
- Principal Investigator
  
  SUGI Haruo
- Project Period (FY)
  2000 – 2001
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  General physiology
- Research Institution
  School of Medicine, Teikyo University
Analysis of functional significance of mutant actin identified in hereditary dilated cardiomyopathy
- Principal Investigator
  
  SUGIURA Seiryo
- Project Period (FY)
  1999 – 2000
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Circulatory organs internal medicine
- Research Institution
  University of Tokyo

All 2014 2013 2012 2011 2010 2009 2008 2007 2006 2005 2004 2003

All Journal Article Presentation

[Journal Article] Adipose natural regulatory B cells negatively control adipose tissue inflammation.2014
- Author(s)
  Nishimura S, Manabe I, Takaki S, Nagaskai M, Ostu M, Yamashita H, Sugita J, Yoshimura K, Eto K, Komuro I, Kadowaki T, Nagai R
- Journal Title
  
  Cell metabolism.
  
  Volume: 18 Pages: 759-766
- DOI
  10.1016/j.cmet.2013.09.017
- NAID
  40020259773
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23591298, KAKENHI-PUBLICLY-24117703, KAKENHI-PROJECT-25293097, KAKENHI-PROJECT-25670471, KAKENHI-PROJECT-25670489
[Journal Article] Adipose natural regulatory B cells negatively control adipose tissue inflammation2013
- Author(s)
  Nishimura S, Manabe I, Takaki S, Nagasaki M, Otsu M, Yamashita H, Sugita J, Yoshimura K, Eto K, Komuro I, Kadowaki T, Nagai R
- Journal Title
  
  Cell Metab
  
  Volume: (Epub ahead of print)(PMID : 24209772)
- Data Source
  KAKENHI-PROJECT-23591298
[Journal Article] In vivo imaging visualizes discoid platelet aggregations without endothelium disruption and implicates contribution of inflammatory cytokine and integrin signaling2012
- Author(s)
  Nishimura S, Manabe I, Nagasaki M, Kakuta S, Iwakura Y, Takayama N, Ooehara J, Otsu M, Kamiya A, Petrich BG, Urano T, Kadono T, Sato S, Aiba A, Yamashita H, Sugiura S, Kadowaki T, Nakauchi H, Eto K, Nagai R
- Journal Title
  
  Blood
  
  Volume: 119(PMID 22096246)
- Data Source
  KAKENHI-PROJECT-23591298
[Journal Article] In vivo imaging visualizes discoid platelet aggregations without endothelium disruption and implicates contribution of inflammatory cytokine and integrin signaling.2012
- Author(s)
  S.Nishimura
- Journal Title
  
  Blood.
  
  Volume: 119 Pages: 128-131
- DOI
  10.1182/blood-2011-09-381400
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20220009, KAKENHI-PROJECT-20229008, KAKENHI-PROJECT-21300160, KAKENHI-PROJECT-21390321, KAKENHI-PROJECT-21590230, KAKENHI-PROJECT-21591231, KAKENHI-PROJECT-22300106, KAKENHI-PROJECT-22700448, KAKENHI-PUBLICLY-23114504, KAKENHI-PROJECT-23591298, KAKENHI-PROJECT-23650214, KAKENHI-PROJECT-23650622, KAKENHI-PROJECT-23659514, KAKENHI-PROJECT-23659533, KAKENHI-PROJECT-23791016, KAKENHI-PROJECT-24659127, KAKENHI-PROJECT-24659489, KAKENHI-PROJECT-24659522
[Journal Article] In vivo imaging visualizes discoid platelet aggregations without endothelium disruption and implicates contribution of inflammatory cytokine and integrin signaling.2012
- Author(s)
  Nishimura S, Manabe I, Nagasaki M, Yamashita H, Sugiura S, Kadowaki T, Nakauchi H, Eto K, Nagai R. and et al.
- Journal Title
  
  Blood
  
  Volume: 119
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23591298
[Journal Article] CD8^+ effector T cells contribute to macrophage recruitment and adipose tissue inflammation in obesity2009
- Author(s)
  Nishimura S, Manabe I, Nagasaki M, Eto K, Yamashita H, Ohsugi M, Otsu M, Hara K, Ueki K, Sugiura S, Yoshimura K, Kadowaki T, Nagai R
- Journal Title
  
  Nature Medicine 15:8
  
  Pages: 914-920
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20591052
[Journal Article] CD8^+ effector T cells contribute to macrophage recruitment and adipose tissue inflammation in obesity2009
- Author(s)
  Nishimura S, Manabe I, Nagasaki M, Eto K, Yamashita H, Ohsugi M, Otsu M, Hara K, Ueki K, Sugiura S, Yoshimura K, Kadowaki T, Nagai R.
- Journal Title
  
  Nature Medicine 15:8
  
  Pages: 914-920
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20591052
[Journal Article] Responses of single-ventricular myocytes to dynamic axial stretching.2008
- Author(s)
  Nishimura, S, Seo, K, Hosoya, Y, Yamashita, H, and et al.
- Journal Title
  
  Progress in Biophysics & Molecular Biology 97
  
  Pages: 282-297
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20591052
[Journal Article] Adipogenesis in obesity requires close interplay between differentiating adipocy tes, stromal cells and blood vessels.2007
- Author(s)
  Nishimura S, Manabe I, Nagasaki M, Hosoya Y, Yamashita H, et al.
- Journal Title
  
  Diabetes. (in press)
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17590710
[Journal Article] Adipogenesis in obesity requires close interplay between differentiating adipocy tes, stromal cells and blood vessels2007
- Author(s)
  Nishimura S, Manabe I, Nagasaki M., Hosoya Y, Yamashita H, et al.
- Journal Title
  
  Diabetes (In press)
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17590710
[Journal Article] Adipogenesis in obesity requires close interplay between differentiating adipocy tes, stromal cells and blood vessels2007
- Author(s)
  Nishimura S, Manabe I, Nagasaki M, Hosoya Y, Yamashita H, et al.
- Journal Title
  
  Diabetes (In press)
- Data Source
  KAKENHI-PROJECT-17590710
[Journal Article] Membrane potential of rat ventricular myocytes responds to axial stretch in phase, amplitude and speed dependent manners.2006
- Author(s)
  Nishimura S, Kawai Y, Hosoya Y, Fujita H, Katoh M, Yamashita H, et al.
- Journal Title
  
  Cardiovasc. Res. 72
  
  Pages: 403-411
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17590710
[Journal Article] Expression of green fluorescent protein impairs the force-generating ability of isolated rat ventricular cardiomyocytes.2006
- Author(s)
  Nishimura S, Nagai S, Sata M, Katoh M, Yamashita H, et al.
- Journal Title
  
  Mol.Cell.Biochem. 286
  
  Pages: 59-65
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17590710
[Journal Article] Membrane potential of rat ventricular myocytes responds to axial stretch in phase, amplitude and speed dependent manners.2006
- Author(s)
  Nishimura S, Kawai Y, Hosoya Y, Fujita H, Katoh M, Yamashita H, et al.
- Journal Title
  
  Cardiovasc.Res. 72
  
  Pages: 403-411
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17590710
[Journal Article] Microtubules modulate the stiffness of cardiomyocytes against shear stress.2006
- Author(s)
  Nishimura S, Nagai S, Katoh M, Yamashita H, et al.
- Journal Title
  
  Circ. Res. 98
  
  Pages: 81-87
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17590710
[Journal Article] Microtubules modulate the stiffness of cardiomyocytes against shear stress.2006
- Author(s)
  Nishimura S, Nagai S, Katoh M, Yamashita H, et al.
- Journal Title
  
  Circ.Res. 98
  
  Pages: 81-87
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17590710
[Journal Article] Expression of green fluorescent protein impairs the force-generating ability of isolated rat ventricular cardiomyocytes.2006
- Author(s)
  Nishimura S, Nagai S, Sata M, Katoh M, Yamashita H, et al.
- Journal Title
  
  Mol Cell. Biochem. 286
  
  Pages: 59-65
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17590710
[Journal Article] Expression of green fluorescent protein impairs the force-generating ability of isolated rat ventricular cardiomyocytes2006
- Author(s)
  Nishimura S, Nagai S, Sata M, Katoh M, Yamashita H, et al.
- Journal Title
  
  Mol.Cell.Biochem. In press
- Data Source
  KAKENHI-PROJECT-17590710
[Journal Article] Contractile dysfunction of cardiomyopathic hamster myocytes is pronounced under high load conditions.2005
- Author(s)
  Nishimura S, Yamashita H, et al.
- Journal Title
  
  J.Mol.Cell.Cardiol. 39
  
  Pages: 231-239
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17590710
[Journal Article] Contractile dysfunction of cardiomyopathic hamster myocytes is pronounced under high load conditions.2005
- Author(s)
  Nishimura S, Yamashita H, et al.
- Journal Title
  
  J. Mol. Cell. Cardiol. 39
  
  Pages: 231-239
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17590710
[Journal Article] Single cell mechanics of rat cardiomyocytes under isometric, unloaded, and physiologically loaded conditions.2004
- Author(s)
  Nishimura S., Yasuda S., Katoh M., Yamada KP., Yamashita H., Saeki Y., Sunagawa K., Nagai R., Hisada T., Sugiura S.
- Journal Title
  
  American Journal of Physiology -Heart & Circulatory Physiology. 287(1)
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15590721
[Journal Article] Measurement of force developed by a single cardiac myocyte using novel carbon fibers.2003
- Author(s)
  Sugiura S., Yasuda S., Yamashita H., Kato K., Saeki Y., Kaneko H., Suda Y., Nagai R., Sugi H.
- Journal Title
  
  Advances in Experimental Medicine & Biology. 538
  
  Pages: 381-387
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15590721
[Journal Article] Unloaded shortening increases peak of Ca2+ transients but accelerates their decay in rat single cardiac myocytes.2003
- Author(s)
  Yasuda S., Sugiura S., Yamashita H., Nishimura S., Saeki Y., Momomura S., Katoh K., Nagai R., Sugi H.
- Journal Title
  
  American Journal of Physiology -Heart & Circulatory Physiology. 285(2)
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15590721
[Journal Article] Myosin light chain isoforms modify force-generating ability of cardiac myosin by changing the kinetics of actin-myosin interaction.2003
- Author(s)
  Yamashita H., Sugiura S., Fujita H., Yasuda S., Nagai R., Saeki Y., Sunagawa K., Sugi H.
- Journal Title
  
  Cardiovascular Research. 60(3)
  
  Pages: 580-588
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15590721
[Journal Article] Myosin light chain isoforms modify force-generating ability of cardiac myosin by changing the kinetics of actin-myosin interaction.2003
- Author(s)
  山下尋史
- Journal Title
  
  Cardiovascular Research 60
  
  Pages: 580-588
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15590721
[Presentation] Adipose Natural Regulatory B Cells Negatively Control Adipose Tissue Inflammation Associated with Obesity (Featured Reserach Session)2013
- Author(s)
  Nisimura S, Nagasaki M, Manabe I, Eto K, Yamashita H, Komuro I, Nagai R
- Organizer
  第77回日本循環器学会学術集会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-23591298
[Presentation] Adipose Natural Regulatory B Cells Negatively Control Adipose Tissue Inflammation Associated with Obesity2013
- Author(s)
  Nisimura S, Nagasaki M, Manabe I, Eto K, Yamashita H, Komuro I, Nagai R
- Organizer
  第77回日本循環器学会学術集会
- Place of Presentation
  横浜(Featured Reserach Session)
- Data Source
  KAKENHI-PROJECT-23591298
[Presentation] Autotaxin Contributes to the Adipose Tissue Expansion and Inflammation in Diet-induced-obesity in Mice2013
- Author(s)
  Nagasaki M, Nishimura S, Manabe I, Uno K, Yamashita H, Nagai R, Komuro I
- Organizer
  第77回日本循環器学会学術集会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-23591298
[Presentation] Adipose Tissue Remodeling and Malfunctioning in Obesity Associated with Chronic Inflammation and Local Immunity2012
- Author(s)
  Nishimura S, Ngasaki M, Manabe I, Eto K, Yamashita H, Nagai R
- Organizer
  第76回日本循環器学会学術集会
- Place of Presentation
  福岡
- Data Source
  KAKENHI-PROJECT-23591298
[Presentation] In Vivo Imaging Visualizes Discoid Platelet Aggregations without Endothelium Disruption and Contribution of Inflammatory Cytokine and Integrin Signaling2012
- Author(s)
  Nishimura S, Ngasaki M, Manabe I, Eto K, Yamashita H, Nagai R
- Organizer
  第76回日本循環器学会学術集会
- Place of Presentation
  福岡
- Data Source
  KAKENHI-PROJECT-23591298
[Presentation] Adipose Tissue Remodeling and Malfunctioning in Obesity Based on Chronic Inflammation and Abnormal Local Immunity2011
- Author(s)
  Nishimura S, Nagasaki M, Manabe I, Eto K, Yamashita H, Nagai R
- Organizer
  第75回日本循環器学会総会・学術集会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-20591052
[Presentation] Adipose Tissue Remodeling and Malfunctioning in Obesity Based on Chronic Inflammation and Abnormal Local Immunity2011
- Author(s)
  Nishimura S, Nagasaki M, Manabe I, Eto K, Yamashita H, Nagai R
- Organizer
  第75回日本循環器学会学術集会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-23591298
[Presentation] In Vivo Molecular Imaging Reveals Multi-cellular Kinetics of Developing Thrombus2011
- Author(s)
  Nishimura S, Nagasaki M, Manabe I, Eto K, Yamashita H, Nagai R
- Organizer
  第75回日本循環器学会総会・学術集会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-20591052
[Presentation] In Vivo Molecular Imaging Reveals Multi-cellular Kinetics of Developing Thrombus2011
- Author(s)
  Nishimura S, Nagasaki M, Manabe I, Eto K, Yamashita H, Nagai R
- Organizer
  第75回日本循環器学会学術集会
- Place of Presentation
  横浜(Featured Research Session)
- Data Source
  KAKENHI-PROJECT-23591298
[Presentation] Adipose Tissue Remodeling and Chronic Inflammation in Obesity : a Novel Key Player, CD8+ T cells2010
- Author(s)
  Nishimura S, Nagasaki M, Manabe I, Yamashita H, Eto K, Nagai R
- Organizer
  第74回日本循環器学会総会・学術集会
- Place of Presentation
  京都
- Data Source
  KAKENHI-PROJECT-20591052
[Presentation] Micromechanical measurement by laser optical tweezer revealed anisotropy in the stiffness of rat ventricular myocytes2010
- Author(s)
  Masumoto S, Fukano H, Iwanami S, Yamashita H, Hisada T, Sugiura S
- Organizer
  The 20^<th> World Congress ISHR
- Place of Presentation
  Kyoto
- Year and Date
  2010-05-16
- Data Source
  KAKENHI-PROJECT-20300152
[Presentation] Multi-cellular Kinetics in Thrombosis Visualized by in Vivo Molecular Imaging (Featured Research Session)2010
- Author(s)
  Nishimura S, Nagasaki M, Manabe I, Yamashita H, Eto K, Nagai R
- Organizer
  第74回日本循環器学会総会・学術集会
- Place of Presentation
  京都
- Data Source
  KAKENHI-PROJECT-20591052
[Presentation] In vivo Imaging Reveals Multi-Cellular Kinetics in Inflammatory Diseases : Adipose Tissue Obesity and Thrombosis2010
- Author(s)
  Nishimura S, Nagasaki M, Manabe I, Yamashita H, Eto K, Nagai R
- Organizer
  第74回日本循環器学会総会・学術集会シンポジウム Topic11 分子イメージング法がもたらす循環器研究の進展
- Place of Presentation
  京都
- Data Source
  KAKENHI-PROJECT-20591052
[Presentation] Micromechanical measurement by laser optical tweezer revealed anisotropy in the stiffness of rat ventricular myocytes2009
- Author(s)
  Masumoto S, Fukano H, Iwanami S, Yamashita H, Hisada T, Sugiura S
- Organizer
  The 26^<th> Annual Meeting of International Society for Heart Research Japanese Section
- Place of Presentation
  Sapporo
- Year and Date
  2009-12-04
- Data Source
  KAKENHI-PROJECT-20300152
[Presentation] Platelet Kinetics in Thrombus Formation, and Inflammatory Status Revealed by in vivo Molecular Imaging2009
- Author(s)
  Nishimura, S, Yamashita, Hand et al.
- Organizer
  第73回日本循環器学会総会・学術集会
- Place of Presentation
  大阪
- Data Source
  KAKENHI-PROJECT-20591052
[Presentation] Induction of Ca^<2+> spark by mechanical stress is dependent on the direction of applied stresss in the rat ventricular myocytes2009
- Author(s)
  Fukano H, Masumoto S, Iwanami S, Yamashita H, Hisada T, Sugiura S
- Organizer
  The 26^<th> Annual Meeting of International Society for Heart Research Japanese Section
- Place of Presentation
  Sapporo
- Year and Date
  2009-12-04
- Data Source
  KAKENHI-PROJECT-20300152
[Presentation] Chronic Inflammation, Macrophage Recruitment and CD8+ T Cell Activation in Obese Adipose Tissue Visualized by in vivo Molecular Imaging2009
- Author(s)
  Nishimura, S, Yamashita, H and et al.
- Organizer
  第73回日本循環器学会総会・学術集会
- Place of Presentation
  大阪
- Data Source
  KAKENHI-PROJECT-20591052
[Presentation] Is the contractile dysfunction of detubulated cardiomyocytes caused only by the asynchrony of Ca^<2+> regulation?2008
- Author(s)
  Fukano H, Seo K, Nishimura S, Yamashita H, Sugiura S
- Organizer
  The 25^<th> Annual Meeting of International Heart Research Japanese Section
- Place of Presentation
  Yokohama
- Year and Date
  2008-12-05
- Data Source
  KAKENHI-PROJECT-20300152
[Presentation] Is the contractile dysfunction of detubulated cardiomyocytes caused only by the asynchrony of Ca2+ regulation?2008
- Author(s)
  Nishimura, S, Yamashita, Hand et al.
- Organizer
  第15回国際心臓研究会日本部総会
- Place of Presentation
  神奈川
- Data Source
  KAKENHI-PROJECT-20591052

1. SUGIURA Seiryo (10272551)

# of Collaborated Projects: 11 results

# of Collaborated Products: 10 results
2. SATA Masataka (80345214)

# of Collaborated Projects: 4 results

# of Collaborated Products: 3 results
3. KATOU Masayoshi (40306345)

# of Collaborated Projects: 3 results

# of Collaborated Products: 9 results
4. HISADA Toshiaki (40126149)

# of Collaborated Projects: 3 results

# of Collaborated Products: 3 results
5. WATANABE Hiroshi (10282500)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
6. FUJITA Hideo (70327336)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
7. AOYAGI Teruhiko (10251240)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
8. SUGI Haruo (20082076)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
9. SHIRAKAWA Ibuki (80236190)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
10. KOBAYASHI Takakazu (00112756)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
11. NISHIMURA Satoshi (80456136)

# of Collaborated Projects: 1 results

# of Collaborated Products: 11 results
12. URANO Tetsumei

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
13. 高木智

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
14. 大津真

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
15. 門脇孝

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
16. 江藤浩之

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
17. 海老原康博

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
18. 長崎実佳

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
19. 佐藤伸一

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

YAMASHITA Hiroshi 山下 尋史

Research Projects

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Co-Researchers

Investigation in the pathogenesis of metabolic syndrome with in vivo molecular imagingPrincipal Investigator

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Multi-scale simulation model of cardiomyocyte based on the micromechanical measurement of subcellular structure

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In vivo molecular imaging analysis of pathophysiology in metabolic syndromePrincipal Investigator

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力伝達障害としての拡張型心筋症の病態メカニズムの解明

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Aphysiomic approach to evaluate the role of mechano-electrical feedback in arrhythmia

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Investigation on the functional significance of myosin subfragment-2Principal Investigator

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Investigation on the functional significance of myosin light chain kinase and myosin light chain phosphorylationPrincipal Investigator

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Development of myosin isoform function in single ventricular myocytesHeart

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Development of novel therapeutic options for treating heart failure targeting the myosin light chainPrincipal Investigator

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Development of a Gene Transfer and Functional Evaluation System for an Isolated Single Cardiac Myocyte as a model for the Gene Therapy

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Molecular mechanism of adaptation in human ventricular myosin

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Analysis of functional significance of mutant actin identified in hereditary dilated cardiomyopathy

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[Journal Article] Adipose natural regulatory B cells negatively control adipose tissue inflammation.2014

Author(s)

Journal Title

DOI

YAMASHITA Hiroshi 山下尋史