Onai Nobuyuki 小内伸幸

… Alternative Names

ONAI Nobuyuki 小内伸幸

ONAI N. Obuyuki 小内伸幸

小内伸幸オナイノブユキ

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Researcher Number	50323605
Other IDs
Affiliation (Current)	2025: 金沢医科大学, 医学部, 教授
Affiliation (based on the past Project Information) *help	2016 – 2024: 金沢医科大学, 医学部, 教授 2012 – 2016: 東京医科歯科大学, 難治疾患研究所, 講師 2008: Akita University, 医学部, 講師 2007: Akita University, 医学部, 助教 2002: 東大, 医学(系)研究科(研究院), 助手 2001: 東京大学, 大学院・医学系研究科, 助手
Review Section/Research Field	Principal Investigator Basic Section 49030:Experimental pathology-related / Immunology / Experimental pathology / Immunology Except Principal Investigator Immunology / Basic Section 49030:Experimental pathology-related / Basic Section 43030:Functional biochemistry-related
Keywords	Principal Investigator 前駆細胞 / 樹状細胞 / 単球 / サイトカイン / 血液前駆細胞 / 免疫学 / 顆粒球 / 細胞系譜追跡 / 造血幹細胞 / 骨髄球系細胞 … More / 細胞分化 / 造血 / 発達異常 / 脳 / 生体防御 / 炎症 / 抗原提示 / 胎生期 / リプログラム / 貪食細胞 / 分化リプログラム / マクロファージ / 単核性貪食細胞 / 単核貪食細胞 / 分化 / 転写因子 / ヒト化マウス / 免疫 / 細胞分化・増殖 / 細胞 / IEL / クリプトパッチ / CCR9 / CCL25 / ケモカインレセプター / ケモカイン … More Except Principal Investigator 樹状細胞 / マクロファージ / CDP / 母体感染 / 胎生期樹状細胞 / アレルギー / PCBP1 / Sortilin / 好酸球 / 蛋白質輸送 / サイトカイン / CDPニッチ / 形質細胞様DC（pDC） / 従来型DC（cDC） / DC前駆細胞（CDP） / 樹状細胞（DC） / IRF8 / 生体分子 / 組織・細胞 / 免疫学 / ALDH / 分化転換 / 免疫寛容 / Treg / CD103陽性cDC / cDC / pDC / E2-2 / マイクロアレイ / 単球 / プレ単球 / GMP / cMoP / rGMP / cGMP / 単球/マクロファージ / ヒトcMop / Cytotoxic T lymphocytes / Dendritic cell / Nod1 / Endotoxin shock / Cytotoxic T lymphocyte / dendritic cell / Cross-priming / NOD1 / 抗原 Less

Identification of novel granulocyte/monocyte progenitors and elucidation of myeloid cell developmental pathwayPrincipal Investigator
- Principal Investigator
  
  小内伸幸
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 49030:Experimental pathology-related
- Research Institution
  Kanazawa Medical University
The disease regulation mechanisms in fetal dendritic cells
- Principal Investigator
  
  SAITO Fumiji
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 49030:Experimental pathology-related
- Research Institution
  Kanazawa Medical University
Sortilinの新規リガンド分泌機構の分子基盤とその好酸球における役割
- Principal Investigator
  
  和田俊樹 (矢部俊樹)
- Project Period (FY)
  2019 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 43030:Functional biochemistry-related
- Research Institution
  Kanazawa Medical University
Functional analysis of fetal dendritic cells and elucidation of inflammation-induced brain development abnormality contributed by fetal dendritic cellsPrincipal Investigator
- Principal Investigator
  
  ONAI Nobuyuki
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 49030:Experimental pathology-related
- Research Institution
  Kanazawa Medical University
Establishment and application of mouse and human phagocytes using differentiation reprogramPrincipal Investigator
- Principal Investigator
  
  Onai Nobuyuki
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Experimental pathology
- Research Institution
  Kanazawa Medical University
  Tokyo Medical and Dental University
Identification of human DC and monocyte progenitors
- Principal Investigator
  
  OHTEKI Toshiaki
- Project Period (FY)
  2015 – 2016
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Immunology
- Research Institution
  Tokyo Medical and Dental University
Comprehensive understanding of dendritic cell progenitor and its therapeutic application basis
- Principal Investigator
  
  OHTEKI Toshiaki
- Project Period (FY)
  2014 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  Immunology
- Research Institution
  Tokyo Medical and Dental University
Identification of mouse and human DC progenitorPrincipal Investigator
- Principal Investigator
  
  ONAI Nobuyuki
- Project Period (FY)
  2012 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Immunology
- Research Institution
  Tokyo Medical and Dental University
Nod1-mediated regulation of immunological homeostasis
- Principal Investigator
  
  SATO Taku, TADA Hiroyuki
- Project Period (FY)
  2007 – 2008
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Immunology
- Research Institution
  Akita University
Identification and isolation of a new common progenitor for dendritic cell subsetsPrincipal Investigator
- Principal Investigator
  
  ONAI Nobuyuki
- Project Period (FY)
  2007 – 2008
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Immunology
- Research Institution
  Akita University
胎生期及び成人期血液前駆細胞の胸腺へのホーミング機構、胸腺内細胞移動機序の解明Principal Investigator
- Principal Investigator
  
  小内伸幸
- Project Period (FY)
  2001 – 2002
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Immunology
- Research Institution
  The University of Tokyo

[Book] “Isolation of mouse dendritic cell progenitor and bone marrow progenitor”. Methods Mol. Biol.2016
- Author(s)
  Onai N & Ohteki T
- Total Pages
  8
- Publisher
  Human Press, UK
- Data Source
  KAKENHI-PROJECT-15H04717
[Journal Article] PCBP1 acts as a regulator of CCL2 expression in macrophages to induce recruitment of monocyte-derived macrophages into the inflamed colon.2023
- Author(s)
  Xinquan Yang, Toshiki Yabe-Wada, Jia Han, Fumiji Saito, Chie Ogasawara, Sohsuke Yamada, Nobuyuki Onai
- Journal Title
  
  International Immunology
  
  Volume: - Issue: 6 Pages: 287-299
- DOI
  10.1093/intimm/dxad003
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K06550, KAKENHI-PROJECT-20K16162, KAKENHI-PROJECT-23K24117
[Journal Article] An optimized cocktail of small molecule inhibitors promotes the maturation of dendritic cells in GM-CSF mouse bone marrow culture2023
- Author(s)
  Matsuba Shintaro、Ura Hiroki、Saito Fumiji、Ogasawara Chie、Shimodaira Shigetaka、Niida Yo、Onai Nobuyuki
- Journal Title
  
  Frontiers in Immunology
  
  Volume: 14 Pages: 1264609-1264609
- DOI
  10.3389/fimmu.2023.1264609
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-23K05607, KAKENHI-PROJECT-23K24117
[Journal Article] A Novel CD135+ Subset of Mouse Monocytes with a Distinct Differentiation Pathway and Antigen-Presenting Properties2022
- Author(s)
  Kamio Naoka、Yokota Asumi、Tokuda Yuichi、Ogasawara Chie、Nakano Masakazu、Nagao Miki、Tashiro Kei、Maekawa Taira、Onai Nobuyuki、Hirai Hideyo
- Journal Title
  
  The Journal of Immunology
  
  Volume: 209 Issue: 3 Pages: 498-509
- DOI
  10.4049/jimmunol.2100024
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21K06840, KAKENHI-PROJECT-21K08379, KAKENHI-PROJECT-21H02687, KAKENHI-PROJECT-20K07343, KAKENHI-PROJECT-20K16162, KAKENHI-PROJECT-23K24117, KAKENHI-PROJECT-21H02956
[Journal Article] Detailed Structure of Mouse Interferon α2 and Its Interaction with Sortilin2021
- Author(s)
  Honoka Watanabe, Toshiki Yabe-Wada, Nobuyuki Onai, Masaki Unno
- Journal Title
  
  Journal of Biochemistry
  
  Volume: in press Issue: 2 Pages: 265-273
- DOI
  10.1093/jb/mvab038
- NAID
  40022722389
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K06507, KAKENHI-PROJECT-19K06550, KAKENHI-PROJECT-18H02644
[Journal Article] PCBP2 post‐transcriptionally regulates sortilin expression by binding to a C‐rich element in its 3′ UTR2020
- Author(s)
  Yabe‐Wada Toshiki、Philpott Caroline C.、Onai Nobuyuki
- Journal Title
  
  FEBS Open Bio
  
  Volume: 10 Issue: 3 Pages: 407-413
- DOI
  10.1002/2211-5463.12794
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K06550, KAKENHI-PROJECT-18H02644
[Journal Article] Calcium Pyrophosphate Dihydrate Crystals Increase the Granulocyte/Monocyte Progenitor (GMP) and Enhance Granulocyte and Monocyte Differentiation In Vivo2020
- Author(s)
  Onai N, Ogasawara C.
- Journal Title
  
  Int J Mol Sci .
  
  Volume: 22 Issue: 1 Pages: 262-262
- DOI
  10.3390/ijms22010262
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18H02644, KAKENHI-PROJECT-20K16162
[Journal Article] Crystal structure of the ligand-free form of the Vps10 ectodomain of dimerized Sortilin at acidic pH.2018
- Author(s)
  Yabe-Wada T, Matsuba S, Unno M, Onai N.
- Journal Title
  
  FEBS Lett.
  
  Volume: 592 Issue: 15 Pages: 2647-2657
- DOI
  10.1002/1873-3468.13181
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18H02644, KAKENHI-PROJECT-16K18518
[Journal Article] Identification of a human clonogenic progenitor with strict monocyte differentiation potential - a counterpart of mouse cMoPs.2017
- Author(s)
  Kawamura S, Onai N, Miya F, Sato T, Tsunoda T, Kurabayashi K, Yotsumoto S, Kuroda S, Takenaka K, Akashi K and Ohteki T.
- Journal Title
  
  Immunity
  
  Volume: 46
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15K15150
[Journal Article] Mast cell hyperactivity underpins the development of oxygen-induced retinopathy.2017
- Author(s)
  Matsuda K, Okamoto N, Kondo M, Arkwright PD, Karasawa K, Ishizaka S, Yokota S, Matsuda A, Jung K, Oida K, Amagai Y, Jang H, Noda E, Kakinuma R, Yasui K, Kaku U, Mori Y, Onai N, Ohteki T, Tanaka A, Matsuda H
- Journal Title
  
  J. Clin. Invest.
  
  Volume: 127 Issue: 11 Pages: 3987-4000
- DOI
  10.1172/jci89893
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PLANNED-26111004, KAKENHI-PROJECT-16H06383, KAKENHI-PROJECT-15H04717, KAKENHI-PROJECT-17H05044, KAKENHI-PROJECT-16J10993, KAKENHI-PROJECT-15H02478
[Journal Article] Identification of a human clonogenic progenitor with strict monocyte differentiation potential - a counterpart of mouse cMoPs.2017
- Author(s)
  Kawamura S, Onai N, Kurabayashi K, Sato T, Miya F, Tsunoda, T, Yotsumoto S, Kuroda S, Takenaka K, Akashi K, Ohteki T.
- Journal Title
  
  Immunity
  
  Volume: 未定
- Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H04717
[Journal Article] Identification of a human clonogenic progenitor with strict monocyte differentiation potential: A counterpart of mouse cMoPs2017
- Author(s)
  Kawamura S, Onai N, Miya F, Sato T, Tsunoda T, Kurabayashi K, Yotsumoto S, Kuroda S, Takenaka K, Akashi K, Ohteki T
- Journal Title
  
  Immunity
  
  Volume: 46 Issue: 5 Pages: 835-848
- DOI
  10.1016/j.immuni.2017.04.019
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-26253029, KAKENHI-PROJECT-16K07211, KAKENHI-PROJECT-16H06391, KAKENHI-PROJECT-15H04717, KAKENHI-PROJECT-15K15365
[Journal Article] Flexible fate commitment of E2-2high common DC progenitors implies tuning in tissue microenvironments2017
- Author(s)
  Onai Nobuyuki、Asano Jumpei、Kurosaki Rumiko、Kuroda Shoko、Ohteki Toshiaki
- Journal Title
  
  International Immunology
  
  Volume: 29 Issue: 10 Pages: 443-456
- DOI
  10.1093/intimm/dxx058
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15H04717
[Journal Article] Intrinsic autophagy is required for the maintenance of intestinal stem cells and for irradiation-induced intestinal regeneration.2017
- Author(s)
  Asano J, Sato T, Ichinose S, Kajita M, Onai N, Shimizu S, Ohteki T.
- Journal Title
  
  Cell reports
  
  Volume: 20 Issue: 5 Pages: 1050-1060
- DOI
  10.1016/j.celrep.2017.07.019
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PUBLICLY-17H05691, KAKENHI-PROJECT-15H04717, KAKENHI-PROJECT-16K19571, KAKENHI-PROJECT-17H01533
[Journal Article] 樹状細胞前駆細胞および樹状細胞サブセットのソーティング2016
- Author(s)
  小内伸幸、樗木俊聡
- Journal Title
  
  実験医学最強のステップUPシリーズ　新版！フローサイトメトリー
  
  Volume: 別冊 Pages: 229-240
- Data Source
  KAKENHI-PROJECT-15K15150
[Journal Article] Cytosine-phosphorothionate- guanine oligodeoxynucleotides exacerbates hemophagocytosis by inducing tumor necrosis factor-α production in mice after bone marrow transplanation.2016
- Author(s)
  Liu J, Guo YM, Onai N, Ohyagi H, Hirokawa M, Takahashi N, Tagawa H, Ubukawa K, Kobayahi I, Tezuka H, Minamiya Y, Ohteki T, and Sawada K.
- Journal Title
  
  Biol Blood Marrow Transplant 2015
  
  Volume: 印刷中 Issue: 4 Pages: 627-636
- DOI
  10.1016/j.bbmt.2015.12.018
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15K15150, KAKENHI-PUBLICLY-15H01485, KAKENHI-PUBLICLY-15H01508, KAKENHI-PROJECT-26253029, KAKENHI-PROJECT-15H04717, KAKENHI-PROJECT-25460586, KAKENHI-PROJECT-26461439, KAKENHI-PROJECT-15K08639
[Journal Article] Isolation of dendritic cell progenitor and bone marrow progenitor cells from mouse.2016
- Author(s)
  Onai N, Ohteki T.
- Journal Title
  
  Methods Mol Biological
  
  Volume: 1423 Pages: 53-59
- DOI
  10.1007/978-1-4939-3606-9_4
- ISBN
  9781493936045, 9781493936069
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-26253029, KAKENHI-PROJECT-15K15150
[Journal Article] 樹状細胞前駆細胞および樹状細胞サブセットのソーティング2016
- Author(s)
  小内伸幸、樗木俊聡
- Journal Title
  
  実験医学　最強のステップUPシリーズ　新版！フローサイトメトリー
  
  Volume: 別冊 Pages: 229-240
- Data Source
  KAKENHI-PROJECT-26253029
[Journal Article] Dendritic cells, monocytes and macrophages: a unified nomenclature based on ontogeny.2014
- Author(s)
  Guilliams, M, Ginhoux, F, Jakubzick, C, Naik, S.H., Onai, N., Schraml, B.U., Segura, E., Tussiwand, R., and Yona, S.
- Journal Title
  
  Nat.Rev. Immunol.
  
  Volume: 14 Issue: 8 Pages: 571-578
- DOI
  10.1038/nri3712
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-24590576
[Journal Article] Bipotent or Oligopotent? A macrophage and DC progenitor revisited.2014
- Author(s)
  Onai, N. and Ohteki, T.
- Journal Title
  
  Immunity
  
  Volume: 41 Issue: 1 Pages: 5-7
- DOI
  10.1016/j.immuni.2014.07.004
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-24590576, KAKENHI-PROJECT-26253029
[Journal Article] Monocyte-derived dendritic cells perform hemophagocytosis to fine-tune excessive immune responses.2013
- Author(s)
  Ohyagi H, Onai N, Sato T., et al.
- Journal Title
  
  Immunity
  
  Volume: 39 Pages: 584-598
- NAID
  40020181881
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24590576
[Journal Article] A Clonogenic Progenitor with Prominent Plasmacytoid Dendritic Cell Developmental Potential2013
- Author(s)
  Onai, N., Kurabayashi, K., Hosoi-Amaike, M., Toyama-Sorimachi, N., Matsushima, K., Inaba, K. and Ohteki T
- Journal Title
  
  Immunity
  
  Volume: (in press) Issue: 5 Pages: 943-957
- DOI
  10.1016/j.immuni.2013.04.006
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23659203, KAKENHI-PROJECT-24590576
[Journal Article] IRF-2 protects quiescent HSCs from type-I interferondependent exhaustion2009
- Author(s)
  Sato, T., Onai, N., Yoshihara, H., Arai, F., Suda, T., and Ohteki, T.
- Journal Title
  
  Nat. Med. (in press)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590489
[Journal Article] The concerted action of GM-CSF and Flt3-ligand on in vivo DC homeostasis2009
- Author(s)
  Kingston, D., Schmid, M.A., Onai, N., Obata-Onai, A., Baumjohann, D., and Manz, M.G.
- Journal Title
  
  Blood (in press)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590490
[Journal Article] Interferon regulatory factor-2 protects quiescent hematopoietic stem cells from type-I interferon- dependent exhaustion2009
- Author(s)
  Sato, T., Onai, N., Yoshihara, H., Arai, F., Suda, T., and Ohteki, T.
- Journal Title
  
  Nat. Med. doi : 10.1038(in press)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590490
[Journal Article] The STATs on dendritic cell development2008
- Author(s)
  Onai, N. and Manz, M.G.
- Journal Title
  
  Immunity 28
  
  Pages: 490-492
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590489
[Journal Article] The STATs on dendritic cell development2008
- Author(s)
  Onai, N.
- Journal Title
  
  Immunity 28
  
  Pages: 490-492
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590490
[Journal Article] 血液前駆細胞から樹状細胞サブセットへの分化経路2008
- Author(s)
  小内伸幸
- Journal Title
  
  実験医学増刊号 26
  
  Pages: 3149-3157
- Data Source
  KAKENHI-PROJECT-19590490
[Journal Article] The STATs on dendritic cell development2008
- Author(s)
  Onai, N.
- Journal Title
  
  Immunity 28
  
  Pages: 490-492
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590489
[Journal Article] 樹状細胞による2008
- Author(s)
  小内伸幸、樗木俊聡
- Journal Title
  
  Th分化制御、分子細胞治療 7
  
  Pages: 58-66
- Data Source
  KAKENHI-PROJECT-19590490
[Journal Article] 樹状細胞によるTh分化制御2008
- Author(s)
  小内伸幸
- Journal Title
  
  分子細胞治療 7
  
  Pages: 58-66
- Data Source
  KAKENHI-PROJECT-19590489
[Journal Article] 血液前駆細胞から樹状細胞サブセットへの分化経路2008
- Author(s)
  小内伸幸、小内亜矢
- Journal Title
  
  実験医学 26
  
  Pages: 3149-3157
- Data Source
  KAKENHI-PROJECT-19590490
[Journal Article] 血液前駆細胞から樹状細胞サブセットへの分化経路2008
- Author(s)
  小内伸幸
- Journal Title
  
  実験医学増刊号 26
  
  Pages: 3149-3157
- Data Source
  KAKENHI-PROJECT-19590489
[Journal Article] The STATs on dendritic cell development2008
- Author(s)
  Onai, N., and Manz, M.G.
- Journal Title
  
  Immunity 28
  
  Pages: 490-492
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590490
[Journal Article] 樹状細胞によるTh分化制御2008
- Author(s)
  小内伸幸
- Journal Title
  
  分子細胞治療 7
  
  Pages: 58-66
- Data Source
  KAKENHI-PROJECT-19590490
[Journal Article] 樹状細胞サブセットの分化経路2007
- Author(s)
  小内伸幸
- Journal Title
  
  生化学 79
  
  Pages: 1143-1148
- NAID
  10020284334
- Data Source
  KAKENHI-PROJECT-19590490
[Journal Article] Identification of clonogenic common Flt3^+M-CSFR^+ plasmacytoid and dendritic cell progenitors in mouse bone marrow.2007
- Author(s)
  Onai, N.
- Journal Title
  
  Nat. Immunol. 8
  
  Pages: 1207-1216
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590489
[Journal Article] 樹状細胞サブセットの分化経路2007
- Author(s)
  小内伸幸、小内亜矢、樗木俊聡
- Journal Title
  
  生化学 79
  
  Pages: 1143-1148
- NAID
  10020284334
- Data Source
  KAKENHI-PROJECT-19590490
[Journal Article] Flt3 in regulation of type-I interferon producing and dendritic cell development2007
- Author(s)
  Onai, N., Obata-Onai, A., Schmid, M., and Manz, MG.
- Journal Title
  
  Ann. N. Y. Acad. Sci. 1106
  
  Pages: 253-261
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590489
[Journal Article] Identification of clonogenic common Flt3^+MCSFR^+plasmacytoid and dendritic cell progenitors in mouse bone marrow2007
- Author(s)
  Onai1, N., Obata-Onai1, A., Schmid, M.A., Ohteki, T., Jarrossay, D., and Manz, M.G.
- Journal Title
  
  Nat. Immunol 8
  
  Pages: 1207-1216
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590489
[Journal Article] Identification of clonogenic common Flt3^+M-CSFR^+plasmacytoid and dendritic cell progenitors in mouse bone marrow2007
- Author(s)
  Onail, N., Obata-Onai1, A., Schmid, M.A., Ohteki, T., Jarrossay, D., and Manz, M.G.
- Journal Title
  
  Nat. Immunol. 8
  
  Pages: 1207-1216
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590490
[Journal Article] Flt3 in regulation of type-I interferon producing and dendritic cell development.2007
- Author(s)
  Onai, N.
- Journal Title
  
  Ann. N.Y. Acad. Sci. 1106
  
  Pages: 253-261
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590490
[Journal Article] Flt3 in regulation of type-I interferon producing and dendritic cell development.2007
- Author(s)
  Onai, N.
- Journal Title
  
  Ann. N. Y. Acad. Sci. 1106
  
  Pages: 253-261
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590489
[Journal Article] 樹状細胞サブセットの分化経路2007
- Author(s)
  小内伸幸
- Journal Title
  
  生化学 79
  
  Pages: 1143-1148
- NAID
  10020284334
- Data Source
  KAKENHI-PROJECT-19590489
[Journal Article] Identification of clonogenic common Flt3^+M-CSFR^+ plasmacytoid and dendritic cell progenitors in mouse bone marrow.2007
- Author(s)
  Onai, N.
- Journal Title
  
  Nat. Immunol. 8
  
  Pages: 1207-1216
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590490
[Journal Article] Flt3 in regulation of type-I interferon producing and dendritic cell development2007
- Author(s)
  Onai, N., Obata-Onai, A., Schmid, M. and Manz, MG.
- Journal Title
  
  Ann. N. Y. Acad. Sci. 1106
  
  Pages: 253-261
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590490
[Presentation] PCBP1 acts as a regulator of CCL2 expression in macrophages to induce recruitment of monocyte-derived macrophages into the inflamed colon2024
- Author(s)
  Onai N, Yang X, Yabe-Wada T, Han J, Saito F, Ogasawara C, Yamada S
- Organizer
  日本免疫学会学術集会
- Data Source
  KAKENHI-PROJECT-23K24117
[Presentation] PCBP1 acts as a regulator of CCL2 expression in macrophages to induce recruitment of monocyte-derived macrophages into the inflamed colon2023
- Author(s)
  Onai N, Yang X, Yabe-Wada T, Han J, Saito F, Ogasawara C, Yamada S
- Organizer
  JSICR/MMCB 2023 Joint Symposium
- Data Source
  KAKENHI-PROJECT-23K24117
[Presentation] Monocyte derived dendritic cells perform hemophagocytosis to fine-tune excessive immune responses during chronic virus infection.2022
- Author(s)
  Nobuyuki Onai
- Organizer
  日本分子生物学会
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23K24117
[Presentation] An optimized small molecule inhibitor cocktail supports maturation of dendritic cells in human monocyte derived dendritic cell culture system.2022
- Author(s)
  Shintaro Matsuba, Shigetaka Shimodaira, Nobuyuki Onai
- Organizer
  日本免疫学会学術集会
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23K24117
[Presentation] Detailed Structure of Mouse Interferon α2 and Its Interaction with Sortilin2021
- Author(s)
  和田俊樹，渡邊ほのか，海野昌喜，小内伸幸
- Organizer
  第85回日本インターフェロン・サイトカイン学会学術集会
- Data Source
  KAKENHI-PROJECT-19K06550
[Presentation] Flexible fate commitment of E2-2high common DC progenitors implies tuning in tissue microenvironments.2018
- Author(s)
  Nobuyuki Onai, Junpei Asano, Rumiko Kurosaki, Shoko Kuroda, Toshiaki Ohteki.
- Organizer
  第28回　日本樹状細胞研究会
- Data Source
  KAKENHI-PROJECT-18H02644
[Presentation] Regulation of pDC development by graded expression of E2-2.2017
- Author(s)
  Nobuyuki Onai and Toshiaki Ohteki.
- Organizer
  The 46th Annual Meeting of The Japanese Society for Immunology.
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H04717
[Presentation] Involvement of poly-rC binding proteins in posttranscriptional regulation of Sortilin, the cytokine trafficking mediator.2017
- Author(s)
  Toshiki Yabe-Wada, Shintaro Matsuba, Kazuya Takeda, Akira Nakamura, Haifeng Shi, Caroline C. Philpott, Nobuyuki Onai.
- Organizer
  5th Annual Meeting of the international Cytokine and Interferon Society.
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H04717
[Presentation] SLPI negatively regulates LPS-induced eosinophil activation via inhibition of Elk-1 phosphorylation.2017
- Author(s)
  4.Shintaro Matsuba, Toshiki Yabe-Wada, Kazuya Takeda, Nobuyuki Onai, Toshiyuki Takai, Akira Nakamura.
- Organizer
  The 46th Annual Meeting of The Japanese Society for Immunology.
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H04717
[Presentation] Regulation of pDC development by graded expression of E2-2.2017
- Author(s)
  Nobuyuki Onai, Junpei Asano, Shoko Kuroda, and Toshiaki Ohteki.
- Organizer
  第27回　日本樹状細胞研究会.
- Data Source
  KAKENHI-PROJECT-15H04717
[Presentation] Identification of Flt3-ligand producing cells by generating Flt3-ligand mCherry reporter mouse.2017
- Author(s)
  Nobuyuki Onai and Toshiaki Ohteki.
- Organizer
  5th Annual Meeting of the international Cytokine and Interferon Society.
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H04717
[Presentation] 単球由来樹状細胞樹状細胞による血球貪食と免疫制御2014
- Author(s)
  小内　伸幸
- Organizer
  第9回　先端血液学セミナー
- Place of Presentation
  東京
- Year and Date
  2014-06-07
- Invited
- Data Source
  KAKENHI-PROJECT-24590576
[Presentation] Identification of M-CSFR- dendritic cell progenitors with prominent pDC developmental potential. : Revised load map for dendritic cell development.2013
- Author(s)
  Onai N., et al
- Organizer
  Annual Meeting of The Japanese Society for Immunology
- Place of Presentation
  Makuhari Messe, Chiba
- Data Source
  KAKENHI-PROJECT-24590576
[Presentation] Monocyte derived dendritic cells perform hemophagocytosis to fine-tune excessive immune responses.2012
- Author(s)
  Onai,N., et al.
- Organizer
  The 20th International Symposium on Molecular Cell Biology of Macrophage.
- Place of Presentation
  Tokyo
- Invited
- Data Source
  KAKENHI-PROJECT-24590576
[Presentation] Monocyte derived dendritic cells perform hemophagocytosis to fine-tune2012
- Author(s)
  Onai N., et al.
- Organizer
  Annual Meeting of The Japanease Society for Immunology
- Place of Presentation
  Kobe
- Data Source
  KAKENHI-PROJECT-24590576
[Presentation] The role of hematopoietic cytokine in dendritic cell subsets development2008
- Author(s)
  Onai, N.
- Organizer
  第38日本免疫学会総会・学術集会
- Place of Presentation
  京都
- Data Source
  KAKENHI-PROJECT-19590490
[Presentation] The role of hematopoietic cytokine in dendritic cell subsets development2008
- Author(s)
  Onai, N
- Organizer
  第38日本免疫学会学術集会
- Place of Presentation
  京都
- Data Source
  KAKENHI-PROJECT-19590489
[Presentation] The role of hematopoietic cytokine in dendritic cell subsets development2008
- Author(s)
  Onai, N.
- Organizer
  第38日本免疫学会学術集会
- Place of Presentation
  京都
- Data Source
  KAKENHI-PROJECT-19590490
[Presentation] Regulation of dendritic cell homeostasis2008
- Author(s)
  Onai, N.
- Organizer
  The 10th International Symposium on Dendritic Cells(招待講演)
- Place of Presentation
  Kobe, Japan
- Data Source
  KAKENHI-PROJECT-19590490
[Presentation] Regulation of dendritic cell homeostasis2008
- Author(s)
  Onai, N.
- Organizer
  The 10th international Symposium on Dendritic Cells(招待講演)
- Place of Presentation
  Kobe, Japan
- Data Source
  KAKENHI-PROJECT-19590489
[Presentation] Regulation of dendritic cell homeostasis2008
- Author(s)
  Onai, N.
- Organizer
  The 10th International Symposium on Dendritic Cells
- Place of Presentation
  神戸
- Data Source
  KAKENHI-PROJECT-19590490
[Presentation] Identification of clonogenic common plasmacytoid and dendritic cell progenitors in mouse bone marrow.2007
- Author(s)
  Onai, N.
- Organizer
  第37回日本免疫学会Late breaking symposiun
- Place of Presentation
  東京
- Year and Date
  2007-11-22
- Data Source
  KAKENHI-PROJECT-19590489
[Presentation] Identification of clonogenic common plasmacytoid and dendritic cell progenitors in mouse bone marrow.2007
- Author(s)
  Onai, N.
- Organizer
  第37回日本免疫学会
- Place of Presentation
  東京
- Year and Date
  2007-11-21
- Data Source
  KAKENHI-PROJECT-19590490
[Presentation] Identification of clonogenic common plasmacytoid and dendritic cell progenitors in mouse bone marrow.2007
- Author(s)
  Onai, N.
- Organizer
  第37回日本免疫学会 Late breaking symposium
- Place of Presentation
  東京
- Year and Date
  2007-11-22
- Data Source
  KAKENHI-PROJECT-19590490
[Presentation] common plasmacytoid and dendritic progenitors in mouse bone marrow2007
- Author(s)
  Onai, N.
- Organizer
  第20回内藤コンファレンス「自然免役の医学・生物学(III)
- Place of Presentation
  神奈川
- Data Source
  KAKENHI-PROJECT-19590490
[Presentation] 樹状細胞分化におけるFlt3シグナル伝達系の役割2007
- Author(s)
  小内伸幸
- Organizer
  第5回北東北血液研究会
- Place of Presentation
  秋田
- Year and Date
  2007-05-12
- Data Source
  KAKENHI-PROJECT-19590490
[Presentation] マウス骨髄における樹状細胞前駆細胞の同定2007
- Author(s)
  小内伸幸
- Organizer
  群馬大学・秋田大学連携グローバルCOEプログラム「生体調節シグナルの統合的研究」第2回若手ミニシンポジウム
- Place of Presentation
  秋田
- Year and Date
  2007-11-03
- Data Source
  KAKENHI-PROJECT-19590490
[Presentation] Prospective isolation of clonogenic common plasmacytoid and dendritic progenitors in mouse bone marrow.2007
- Author(s)
  Onai, N.
- Organizer
  第20回内藤コンファレンス「自然免役の医学・生物学(III)」
- Place of Presentation
  葉山
- Data Source
  KAKENHI-PROJECT-19590489
[Presentation] Prospective isolation of clonogenic common plasmacytoid and dendritic progenitors in mouse bone marrow.2007
- Author(s)
  Onai, N.
- Organizer
  第20回内藤コンファレンス「自然免役の医学・生物学(III)」
- Place of Presentation
  葉山
- Data Source
  KAKENHI-PROJECT-19590490
[Presentation] マウス骨髄における樹状細胞前駆細胞の同定2007
- Author(s)
  小内伸幸
- Organizer
  第2回群馬大学・秋田大学連携グローバルCOEプログラム「生体調節シグナルの統合的研究」第一回若手ミニシンポジウム
- Place of Presentation
  秋田
- Year and Date
  2007-11-03
- Data Source
  KAKENHI-PROJECT-19590489
[Presentation] Identification of clonogenic common plasmacytoid and dendritic cell progenitors in mouse bone marrow2007
- Author(s)
  Onai, N.
- Organizer
  第37回日本免疫学会総会・学術集会Late breaking symposium
- Place of Presentation
  東京
- Year and Date
  2007-11-22
- Data Source
  KAKENHI-PROJECT-19590490
[Presentation] Identification of clonogenic common plasmacytoid and dendritic cell progenitors in mouse bone marrow.2007
- Author(s)
  Onai, N.
- Organizer
  第37回日本免疫学会
- Place of Presentation
  東京
- Year and Date
  2007-11-21
- Data Source
  KAKENHI-PROJECT-19590489
[Presentation] マウス骨髄における樹状細胞前駆細胞の同定2007
- Author(s)
  小内伸幸
- Organizer
  第2回群馬大学・秋田大学連携グローバルCOEプログラム「生体調節シグナルの統合的研究」第一回若手ミニシンポジウム
- Place of Presentation
  秋田
- Year and Date
  2007-11-03
- Data Source
  KAKENHI-PROJECT-19590490
[Presentation] Identification of a new dendritic cell progenitor with prominent plasmacytoid dendritic cell developmental potential.
- Author(s)
  Onai　N.
- Organizer
  The 9th International Symposium of the Institute Network.
- Place of Presentation
  Kobe
- Year and Date
  2014-06-19 – 2014-06-20
- Invited
- Data Source
  KAKENHI-PROJECT-24590576
[Presentation] Plasmacytoid dendritic cell development.
- Author(s)
  Onai　N.
- Organizer
  The 22nd International
- Place of Presentation
  Osaka
- Year and Date
  2014-06-02 – 2014-06-03
- Invited
- Data Source
  KAKENHI-PROJECT-24590576

1. SATO Taku (40375259)

# of Collaborated Projects: 2 results

# of Collaborated Products: 1 results
2. TADA Hiroyuki (70431632)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
3. OHTEKI Toshiaki (50233200)

# of Collaborated Projects: 2 results

# of Collaborated Products: 6 results
4. 和田俊樹 (10451634)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
5. TEZUKA Hiroyuki (30375258)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. SAITO Fumiji (20569016)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. 松葉慎太郎 (40367462)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
8. 海野昌喜 (10359549)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
9. YABE Toshiki

# of Collaborated Projects: 0 results

# of Collaborated Products: 4 results
10. MORI masayuki

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
11. NAKANO Masakazu

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
12. 森泰生

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
13. 浦大樹

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
14. 徳田雄市

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
15. 田代啓

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
16. 清水重臣

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
17. 稲葉カヨ

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Onai Nobuyuki 小内 伸幸

ONAI Nobuyuki 小内 伸幸

ONAI N. Obuyuki 小内 伸幸

小内 伸幸 オナイ ノブユキ

Research Projects

Research Products

Co-Researchers

Identification of novel granulocyte/monocyte progenitors and elucidation of myeloid cell developmental pathwayPrincipal Investigator

Principal Investigator

Project Period (FY)

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The disease regulation mechanisms in fetal dendritic cells

Principal Investigator

Project Period (FY)

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Review Section

Research Institution

Sortilinの新規リガンド分泌機構の分子基盤とその好酸球における役割

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Functional analysis of fetal dendritic cells and elucidation of inflammation-induced brain development abnormality contributed by fetal dendritic cellsPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Establishment and application of mouse and human phagocytes using differentiation reprogramPrincipal Investigator

Principal Investigator

Project Period (FY)

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Research Field

Research Institution

Identification of human DC and monocyte progenitors

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Comprehensive understanding of dendritic cell progenitor and its therapeutic application basis

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Identification of mouse and human DC progenitorPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Nod1-mediated regulation of immunological homeostasis

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Identification and isolation of a new common progenitor for dendritic cell subsetsPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

胎生期及び成人期血液前駆細胞の胸腺へのホーミング機構、胸腺内細胞移動機序の解明Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Book] “Isolation of mouse dendritic cell progenitor and bone marrow progenitor”. Methods Mol. Biol.2016

Author(s)

Total Pages

Publisher

Data Source

[Journal Article] PCBP1 acts as a regulator of CCL2 expression in macrophages to induce recruitment of monocyte-derived macrophages into the inflamed colon.2023

Author(s)

Onai Nobuyuki 小内伸幸

ONAI Nobuyuki 小内伸幸

ONAI N. Obuyuki 小内伸幸

小内伸幸オナイノブユキ