Konno Hiroyuki 今野博行

… Alternative Names

KONNO Hiroyuki 今野博行

ONOZUKA Mari

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Researcher Number	50325247
Other IDs
External Links
Affiliation (Current)	2025: 山形大学, 大学院理工学研究科, 教授
Affiliation (based on the past Project Information) *help	2021 – 2024: 山形大学, 大学院理工学研究科, 教授 2018 – 2019: 山形大学, 大学院理工学研究科, 教授 2017: 山形大学, 理工学研究科, 教授 2016 – 2017: 山形大学, 大学院理工学研究科, 准教授 2012 – 2015: 山形大学, 理工学研究科, 准教授 … More 2009 – 2012: Yamagata University, 大学院・理工学研究科, 准教授 2008: Kyoto Prefectural University of Medicine, 大学院・医学研究科, 助教 2006 – 2008: 京都府立医科大学, 医学研究科, 助教 2007: Kyoto Pref. Univ. Med., Grad. Sch. Med. Sci., Assistant Prof. 2004 – 2006: 京都府立医科大学, 医学研究科, 助手 2002 – 2003: 徳島大学, 工学部, 助手 Less
Review Section/Research Field	Principal Investigator Drug development chemistry / Bioorganic chemistry / Medium-sized Section 38:Agricultural chemistry and related fields / Chemical pharmacy Except Principal Investigator Basic Section 48020:Physiology-related / Chemical pharmacy / Basic Section 38040:Bioorganic chemistry-related / Environmental and hygienic pharmacy / Applied microbiology / Respiratory organ internal medicine / Applied biochemistry
Keywords	Principal Investigator 異常アミノ酸 / 細胞毒性 / 蛍光プローブ / TAK779 / 固相合成法 / 立体制御合成 / カリペルチン / 固相合成 / 不斉合成 / アジリジン … More / システインプロテアーゼ阻害剤 / 二次構造制御 / 分子認識 / 蛋白質ラベリング技術 / ラジカル酸化反応 / 可逆的アミノ基検出技術 / 薬物動態 / 活性酸素除去 / アルドール縮合 / フラン誘導体 / クルクミンダイマー / フラノン誘導体 / 構造活性相関 / 凝集阻害 / ドッキングシミレーション / ラジカルスカベンジャー / 水溶性 / クルクミン / 蛍光検出剤 / 凝集阻害剤 / アミロイドβ / 固相ペプチド合成 / ホモフィミン / マクロラクトン化反応 / TAK779誘導体 / HEK/CCR5 / 蛍光標識化 / ペプチド固相合成法 / CCR5阻害剤 / 環状デプシペプチド / 海綿産天然物 / 原蛋白質 / CCR5 / HIVウイルス / 抗HIV活性 / ジメチルグルタミン / callipeltin B / ケモカインレセプター / 抗 HIV活性 / 環状ペプチド / 抗HIV / 有機化学 / 生理活性 / 生体分子 / ウイルス / 合成化学 / 医薬品化学 / システインプロテアーゼ阻害 / カテプシンD / 天然有機化合物 / 海綿 / カテプシンB / ペプチド / 立体選択的合成 / 超原子価試薬 / スタチン / アルドール反応 / 遷移状態アナログ / ペンタペプチド / 全合成 / ペプチドミミック … More Except Principal Investigator COPD / SCGB3A2 / 阻害剤 / SARS / ペプチド / STAT / チアミン / マクロファージ / Decahydroisoquinoline / Fused ring scaffold / Inhibitor / SARS 3CL protease / デカヒドロイソキノリン / SARS 3CLプロテアーゼ / COVID-19 / 呼吸器疾患 / 感染 / PnuT / トランスポーター / ヘリコバクター・ピロリ / 結晶構造解析 / ニゲロオリゴ糖 / 転移反応 / α-1,3-グルカナーゼ / STAT3 / STAT1 / A1AT / 肺気腫 / aziridine / miraziridine A / inhibitor / 3CL-protease / Tokaramide A / アジリジン / Miraziridine A / 3CLプロテアーゼ / keratinocvte / genomic analysis / ultra violet / toxicology / cosmetic additives / 酵母 / 転写調節 / 情報伝達 / チアミンピロリン酸 / プロテアーゼ / Retro-Inverso / Dアミノ酸 / 構造解析 / プロテアーゼ阻害剤 / HTLV-1 Less

次世代のCOPD治療を実現するSCGB3A2ペプチド薬の開発
- Principal Investigator
  
  黒谷玲子
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 48020:Physiology-related
- Research Institution
  Yamagata University
Reversible detection of amino group and protein labeling methodologyPrincipal Investigator
- Principal Investigator
  
  今野博行
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Challenging Research (Exploratory)
- Review Section
  
  Medium-sized Section 38:Agricultural chemistry and related fields
- Research Institution
  Yamagata University
COPD治療薬の応用を目指したSCGB3A2ペプチド薬の創製と有効性の検証
- Principal Investigator
  
  黒谷玲子
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 48020:Physiology-related
- Research Institution
  Yamagata University
Optimization of SARS 3CL protease inhibitor and development of anti-COVID-19 drug
- Principal Investigator
  
  hattori Yasunao
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 38040:Bioorganic chemistry-related
- Research Institution
  Kyoto Pharmaceutical University
Transglycosylation activity of alpha-1,3-glucanase Agl-KA under semi-dry condition
- Principal Investigator
  
  YANO Shigekazu
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Applied microbiology
- Research Institution
  Yamagata University
Design, synthesis and evaluation of curcumin analogues toward amyloid peptide aggregation inhibition and detectionPrincipal Investigator
- Principal Investigator
  
  Konno Hiroyuki
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Bioorganic chemistry
- Research Institution
  Yamagata University
Basic research aiming at the application of SCGB3A2 for chronic obstructive pulmonary disease therapeutic drug.
- Principal Investigator
  
  Kurotani Reiko
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Respiratory organ internal medicine
- Research Institution
  Yamagata University
Mechanism of thiamin transport in Helicobacter pylori providing a basis for complementary therapy for the infection.
- Principal Investigator
  
  Nosaka Kazuto
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Environmental and hygienic pharmacy
- Research Institution
  Mukogawa Women's University
Structure activity relationship study of cyclic depsipetide callipeltins with anti-HIV activityPrincipal Investigator
- Principal Investigator
  
  Konno Hiroyuki
- Project Period (FY)
  2013 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Bioorganic chemistry
- Research Institution
  Yamagata University
Development of a novel persistent protease inhibitor containing D-amino acid
- Principal Investigator
  
  AKAJI Kenichi
- Project Period (FY)
  2009 – 2011
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Chemical pharmacy
- Research Institution
  Kyoto Pharmaceutical University
  Kyoto Prefectural University of Medicine
Design and synthesis of the inhibitors for chemokine receptor CCR5Principal Investigator
- Principal Investigator
  
  KONNO Hiroyuki
- Project Period (FY)
  2009 – 2012
- Research Category
  
  Grant-in-Aid for Young Scientists (A)
- Research Field
  
  Drug development chemistry
- Research Institution
  Yamagata University
Synthesis and inhibitory activity of cyclic depsi-peptide with anti-HIV activityPrincipal Investigator
- Principal Investigator
  
  KONNO Hiroyuki
- Project Period (FY)
  2007 – 2008
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Drug development chemistry
- Research Institution
  Kyoto Prefectural University of Medicine
Signal transduction mechanism underlying thiamin starvation-induced metabolic regulation in Saccharomyces cerevisiae
- Principal Investigator
  
  NOSAKA Kazuto
- Project Period (FY)
  2006 – 2007
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Applied biochemistry
- Research Institution
  Kyoto Prefectural University of Medicine
Development of SARS virus inhibitor using unusual amino acid-containing natural products as seeds
- Principal Investigator
  
  AKAJI Kenichi
- Project Period (FY)
  2006 – 2007
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Chemical pharmacy
- Research Institution
  Kyoto Prefectural University of Medicine
異常アミノ酸含有ペプチド類の全合成と医薬品への展開Principal Investigator
- Principal Investigator
  
  今野博行
- Project Period (FY)
  2004 – 2006
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Drug development chemistry
- Research Institution
  Kyoto Prefectural University of Medicine
生物活性を有する異常アミノ酸含有ペプチドの合成とペプチドミミックへの展開Principal Investigator
- Principal Investigator
  
  今野博行
- Project Period (FY)
  2002 – 2003
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Chemical pharmacy
- Research Institution
  The University of Tokushima

[Book] 遺伝子医学MOOK別冊―次世代ペプチド医薬創製―2014
- Author(s)
  今野博行
- Total Pages
  131
- Publisher
  メディカルドウ
- Data Source
  KAKENHI-PROJECT-25450145
[Book] 遺伝子医学MOOK21号―最新ペプチド合成技術とその創薬研究への応用―2012
- Author(s)
  今野博行
- Total Pages
  307
- Publisher
  メディカルドウ
- Data Source
  KAKENHI-PROJECT-21689004
[Book] 海綿から単離された異常アミノ酸含有ペプチドの合成2012
- Author(s)
  今野博行
- Publisher
  遺伝子医学 MOOK21号.最新ペプチド合成技術とその創薬研究への応用.,メディカルドウ(編集)木曽良明
- Data Source
  KAKENHI-PROJECT-21689004
[Book] コンビナトリアル・バイオエンジニアリング(普及版)2010
- Author(s)
  今野博行
- Total Pages
  351
- Publisher
  CMC出版
- Data Source
  KAKENHI-PROJECT-21689004
[Book] コンビナトリアル・バイオエンジニアリング (普及版)2010
- Author(s)
  今野博行
- Publisher
  CMC出版(監修)植田充美
- Data Source
  KAKENHI-PROJECT-21689004
[Book] コンビナトリアルバイオエンジニアリングの最前線2004
- Author(s)
  今野博行
- Total Pages
  351
- Publisher
  シーエムシー出版
- Data Source
  KAKENHI-PROJECT-16790084
[Journal Article] Structure activity relationship study of NHPI derivatives for ReD-A method and the application for the Fmoc-SPPS.2023
- Author(s)
  Takamatsu, K.; Suzuki, R.; Matsunaga, A.; Katagiri, H.; Konno, H.
- Journal Title
  
  J. Org. Chem.
  
  Volume: 88 Pages: 1319-1326
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22K19125
[Journal Article] Improved synthesis of 2,4,6-trialkylpyridines from 1,5-diketoalkanes: the total synthesis of Anibamine2019
- Author(s)
  Miyakoshi Takeru、Konno Hiroyuki
- Journal Title
  
  Organic & Biomolecular Chemistry
  
  Volume: 17 Issue: 11 Pages: 2896-2905
- DOI
  10.1039/c8ob02723d
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16K07709
[Journal Article] Design, synthesis and evaluation of curcumin-based fluorescent probes to detect Aβ fibrils2018
- Author(s)
  Sato Taki、Hotsumi Mayumi、Makabe Koki、Konno Hiroyuki
- Journal Title
  
  Bioorganic & Medicinal Chemistry Letters
  
  Volume: 28 Issue: 22 Pages: 3520-3525
- DOI
  10.1016/j.bmcl.2018.10.002
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16K07709
[Journal Article] Investigation for the cyclization efficiency of linear tetrapeptides: Synthesis of tentoxin B and dihydrotentoxin2018
- Author(s)
  Sato Ryota、Oyama Kie、Konno Hiroyuki
- Journal Title
  
  Tetrahedron
  
  Volume: 74 Issue: 42 Pages: 6173-6181
- DOI
  10.1016/j.tet.2018.09.011
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16K07709
[Journal Article] Asymmetric synthesis of (2S,3S)-3-Me-glutamine and (R)-allo-threonine derivatives proper for solid-phase peptide coupling2018
- Author(s)
  Tokairin Yoshinori、Soloshonok Vadim A.、Moriwaki Hiroki、Konno Hiroyuki
- Journal Title
  
  Amino Acids
  
  Volume: 51 Issue: 3 Pages: 419-432
- DOI
  10.1007/s00726-018-2677-5
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16J00465, KAKENHI-PROJECT-16K07709
[Journal Article] Deletion of uncharacterized domain from α-1,3-glucanase of <i>Bacillus circulans</i> KA-304 enhances heterologous enzyme production in <i>Escherichia coli</i>2018
- Author(s)
  Yano Shigekazu、Suyotha Wasana、Zanma Sumika、Konno Hiroyuki、Cherdvorapong Vipavee、Wakayama Mamoru
- Journal Title
  
  J. Gen. Appl. Microbiol.
  
  Volume: 64 Issue: 5 Pages: 212-220
- DOI
  10.2323/jgam.2017.12.005
- NAID
  130007503367
- ISSN
  0022-1260, 1349-8037
- Language
  English
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K07709
[Journal Article] Deletion of uncharacterized domain from α-1,3-glucanase of Bacillus circulans KA-304 enhances heterologous enzyme production in Escherichia coli2018
- Author(s)
  Shigekazu Yano, Wasana Suyoth, Sumika Zanma, Hiroyuki Konno, Vipavee Cherdvorapong, Mamoru Wakayama
- Journal Title
  
  The Journal of General and Applied Microbiology
  
  Volume: 印刷中
- NAID
  130007503367
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K07708
[Journal Article] Synthesis of fully protected (2R, 3R, 4S)-4-amino-7-guanidino-3,4-dihydroxy heptanoic acid2017
- Author(s)
  Yoshino, R.; Tokairin, Y.; Konno H.
- Journal Title
  
  Tetrahedron Letters
  
  Volume: 58 Issue: 16 Pages: 1604-1606
- DOI
  10.1016/j.tetlet.2017.03.025
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-16J00465, KAKENHI-PROJECT-16K07709
[Journal Article] Synthesis and evaluation of phenylisoserine derivatives for the SARS-CoV 3CL protease inhibitor2017
- Author(s)
  Konno Hiroyuki、Onuma Takumi、Nitanai Ikumi、Wakabayashi Masaki、Yano Shigekazu、Teruya Kenta、Akaji Kenichi
- Journal Title
  
  Bioorg. Med. Chem. Lett.
  
  Volume: 27 Issue: 12 Pages: 2746-2751
- DOI
  10.1016/j.bmcl.2017.04.056
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16K07709, KAKENHI-PROJECT-16H05104, KAKENHI-PROJECT-15K01804
[Journal Article] Development of reagent for the Fmoc protection to avoid formation of Fmoc-βAla-OH.2017
- Author(s)
  Yoshino, R.; Kikuchi, M.; Konno, H.
- Journal Title
  
  Peptide Science 2016
  
  Volume: 2017 Pages: 71-72
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16K07709
[Journal Article] Synthesis of a secretoglobin 3A2 type C (98?139) fragment by Dawson’s native chemical ligation2017
- Author(s)
  Kikuchi Mariko、Kurotani Reiko、Konno Hiroyuki
- Journal Title
  
  Tetrahedron Lett.
  
  Volume: 58 Issue: 43 Pages: 4145-4148
- DOI
  10.1016/j.tetlet.2017.09.058
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16K07709
[Journal Article] Fmoc-OPhtht, the reagent of Fmoc protection2017
- Author(s)
  Yoshino, R.; Tokairin, Y.; Kikuchi, M; Konno H.
- Journal Title
  
  Tetrahedron Letters
  
  Volume: 58 Issue: 16 Pages: 1600-1603
- DOI
  10.1016/j.tetlet.2017.03.021
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-16J00465, KAKENHI-PROJECT-16K07709
[Journal Article] Synthesis of a secretoglobin 3A2 type C (98-139) fragment by Dawson’s native chemical ligation2017
- Author(s)
  Kikuchi M, Kurotani R, Konno H.
- Journal Title
  
  Tetrahedron Letters.
  
  Volume: 58 Pages: 4145-4148
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15K09208
[Journal Article] Preparation of (2R, 3R, 4R)-3-hydroxy-2,4,6-trimethylheptanoic acid via enzymatic desymmetrization2017
- Author(s)
  Tokairin, Y.; Konno, H.
- Journal Title
  
  Tetrahedron
  
  Volume: 73 Issue: 1 Pages: 39-45
- DOI
  10.1016/j.tet.2016.11.050
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-16J00465, KAKENHI-PROJECT-16K07709
[Journal Article] Design and synthesis of curcumin analogues as probe for Aβ fibrils.2017
- Author(s)
  Sato, T.; Nikaido, Y.; Yamada, R.; Konno, H.
- Journal Title
  
  Peptide Science 2016
  
  Volume: 2017 Pages: 201-202
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16K07709
[Journal Article] Cytotoxic evaluation of natural and synthetic callipeltins: a revision of cytotoxicity of callipeltin B.2016
- Author(s)
  Kikuchi, M.; Konno, H.
- Journal Title
  
  Biosci. Biotechnol. Biochem.
  
  Volume: 80 Issue: 6 Pages: 1066-1069
- DOI
  10.1080/09168451.2016.1148581
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16K07709
[Journal Article] Synthesis of β-Hydroxytyrosine, A Component of Burkholdines.2016
- Author(s)
  Konno, H.; Sasaki, Y.; Sato, R.; Zhu, X.-M.; Otsuki, Y.; Ikoma, M.
- Journal Title
  
  Nat. Prod. Commun.
  
  Volume: 11 Pages: 213-218
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16K07709
[Journal Article] Synthesis of orthogonally protected (2R,3R,4S)-4-amino-2,3-dihydroheptan-1,7-dioic acid.2015
- Author(s)
  Tokairin, Y.; Maita, K.; Takeda, S.; Konno, H.
- Journal Title
  
  Synthesis
  
  Volume: 47 Issue: 03 Pages: 351-358
- DOI
  10.1055/s-0034-1378902
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-25450145
[Journal Article] Synthesis and evaluation of aminopyridine derivatives as potential BACE1 inhibitors.2015
- Author(s)
  Konno, H.; Sato, T.; Saito Y.; Sakamoto, I.; Akaji, K.
- Journal Title
  
  Bioorg. Med. Chem. Lett.
  
  Volume: 25 Issue: 22 Pages: 5127-5132
- DOI
  10.1016/j.bmcl.2015.10.007
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25450145, KAKENHI-PROJECT-16K07709
[Journal Article] Structure activity relationship study of burkholdine analogues toward simple antifungal agents.2015
- Author(s)
  Konno, H.; Abumi, K.; Sasaki, Y.; Yano, S.; Nosaka, K.
- Journal Title
  
  Bioorg. Med. Chem. Lett.
  
  Volume: 25 Issue: 16 Pages: 3199-3202
- DOI
  10.1016/j.bmcl.2015.05.088
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25450145
[Journal Article] Synthetic studies on homophymine B: solid phase synthesis of a cyclic fragment.2015
- Author(s)
  Tokairin, Y.; Takeda, S.; Kikuchi, M.; Konno, H.
- Journal Title
  
  Tetrahedron Lett.
  
  Volume: 56 Issue: 21 Pages: 2809-2812
- DOI
  10.1016/j.tetlet.2015.04.044
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-25450145
[Journal Article] Synthetic study of peptide aldehydes via acetal/thioacetal transformation: application for Lys/Ser-containing peptides.2015
- Author(s)
  Konno, H.; Sema, Y.; Tokairin, Y.
- Journal Title
  
  Tetrahedron
  
  Volume: 71 Issue: 21 Pages: 3433-3438
- DOI
  10.1016/j.tet.2015.03.080
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25450145
[Journal Article] Structure activity relationship study of curcumin analogues toward the amyloid-beta aggregation inhibitor.2014
- Author(s)
  Endo, H.; Nikaido, Y.; Nakadate, M.; Ise, S.; Konno, H.
- Journal Title
  
  Bioorg. Med. Chem. Lett.
  
  Volume: 24 Issue: 24 Pages: 5621-5626
- DOI
  10.1016/j.bmcl.2014.10.076
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25450145
[Journal Article] Stereochemical assignment of four diastereoisomers of 3,4-dimethylpyroglutamic acid, a moiety of callipeltin B2014
- Author(s)
  Mari Kikuchi, Hiroyuki Konno
- Journal Title
  
  Heterocycles
  
  Volume: 89 Issue: 7 Pages: 1620-1631
- DOI
  10.3987/com-14-13003
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-12J08696, KAKENHI-PROJECT-25450145
[Journal Article] Total synthesis of callipeltin B and M, peptidyl marine natural products2014
- Author(s)
  Mari Kikuchi, Hiroyuki Konno
- Journal Title
  
  Organic Letters
  
  Volume: 16 Issue: 16 Pages: 4324-4327
- DOI
  10.1021/ol5020619
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-12J08696, KAKENHI-PROJECT-25450145
[Journal Article] Effect of prome-site sequence of retro-inverso-modified HTLV-1 protease inhibitor.2014
- Author(s)
  Awahara, C.; Tatsumi, T.; Furuta, S.; Shinjoh, G.; Konno, H.; Nosaka, K.; Kobayashi, K.; Hattori, Y.; Akaji, K.
- Journal Title
  
  Bioorg. Med. Chem.
  
  Volume: 22 Issue: 8 Pages: 2482-2488
- DOI
  10.1016/j.bmc.2014.02.050
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25450145, KAKENHI-PROJECT-25460160
[Journal Article] Enzymatic and structural characterization of an archaeal thiamin phosphate synthase.2014
- Author(s)
  Hayashi, M.; Kobayashi, K.; Esaki, H.; Konno, H.; Akaji, K.; Tazuya, K.; Yamada, K.; Nosaka, K.
- Journal Title
  
  BBA-Proteins and Proteomics
  
  Volume: 1844 Issue: 4 Pages: 803-809
- DOI
  10.1016/j.bbapap.2014.02.017
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25450145
[Journal Article] Synthesis and evaluation of inhibitory activity of the curcumin derivatives toward the inhibitor of beta-site amyloid precursor protein cleaving enzyme 1.2014
- Author(s)
  Konno, H.; Endo, H.; Ise, S.; Miyazaki, K.; Aoki, H.; Sanjo, A.; Hattori, Y.; Akaji, K.
- Journal Title
  
  Bioorg. Med. Chem. Lett.
  
  Volume: 24 Issue: 2 Pages: 685-690
- DOI
  10.1016/j.bmcl.2013.11.039
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25450145, KAKENHI-PROJECT-25460160
[Journal Article] Solid phase total synthesis and cytotoxicity of callipeltin E and M2013
- Author(s)
  Kukuchi, M.; Konno, H.
- Journal Title
  
  the linear peptides isolated from marine sponge Latrunculia sp
  
  Volume: in preparation
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21689004
[Journal Article] Total synthesis of (+)-azimine via diastereoselective aminopalladation2013
- Author(s)
  Kurogome, Y.; Kogiso, M.; Looi, K. K.; Hattori, Y.; Konno, H.; Hirota, M.; Makabe, H.
- Journal Title
  
  Tetrahedron
  
  Volume: 69 Issue: 39 Pages: 8349-8352
- DOI
  10.1016/j.tet.2013.07.083
- NAID
  120007106213
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24580160, KAKENHI-PROJECT-25450145
[Journal Article] Improved synthesis of D-allothreonine derivatives from L-threonine2013
- Author(s)
  Mari Kikuchi, Hiroyuki Konno
- Journal Title
  
  Tetrahedron
  
  Volume: 69 Issue: 34 Pages: 7098-7101
- DOI
  10.1016/j.tet.2013.06.027
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-12J08696, KAKENHI-PROJECT-25450145
[Journal Article] Structure Activity Relationship Study of Callipeltin B for the Cytotoxic Activity2013
- Author(s)
  Kikuchi , M.; Konno, H.
- Journal Title
  
  Peptide Science 2012
  
  Pages: 145-148
- NAID
  10031161580
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21689004
[Journal Article] Synthesis and evaluation of Serine Derivatives for SARS 3CL protease2013
- Author(s)
  Konno, H
- Journal Title
  
  Peptide Science 2012
  
  Volume: なし Pages: 143-144
- NAID
  10031161579
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21689004
[Journal Article] Synthesis and antifungal activities of cyclic octa-lipopeptide burkholdine analogues2013
- Author(s)
  Konno, H.; Otsuki, Y.; Matsuzaki, K.; Nosaka, K.
- Journal Title
  
  Bioorg. Med. Chem. Lett.
  
  Volume: 23 Issue: 14 Pages: 4244-4247
- DOI
  10.1016/j.bmcl.2013.04.091
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25450145
[Journal Article] Practical synthesis of peptide C-terminal aldehyde on a solid support2013
- Author(s)
  Konno, H.; Sema, Y.; Ishii, M.; Hattori, Y.; Nosaka, K.; Akaji, K.
- Journal Title
  
  Tetrahedron Lett.
  
  Volume: 54 Issue: 36 Pages: 4848-4850
- DOI
  10.1016/j.tetlet.2013.06.103
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25450145, KAKENHI-PROJECT-25460160
[Journal Article] Improved synthesis of Fmoc-D-allothreonine derivatives from L-threonine2013
- Author(s)
  Kikuchi, M.; Konno, H.
- Volume
  (in press)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21689004
[Journal Article] Synthetic Study of Depsipeptides Analogues of callipeltin B and Its Cytotoxicity2012
- Author(s)
  Kikuchi, M.; Watanabe, Y; Tanaka, M.; Akaji, K.; Konno, H.
- Journal Title
  
  Peptide Science 2011
  
  Pages: 111-114
- NAID
  10030204094
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21689004
[Journal Article] Synthetic study of bioactive natural product as protein inhibitors2012
- Author(s)
  Konno, H.
- Journal Title
  
  Biosci. Biotechnol. Biochem
  
  Volume: 76(6) Pages: 1-5
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21689004
[Journal Article] Synthetic study of bioactive natural product as protein inhibitors2012
- Author(s)
  Konno, H.
- Journal Title
  
  Biosci. Biotechnol. Biochem.
  
  Volume: 76 Pages: 1-5
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21689004
[Journal Article] Synthetic study of callipeltin B analogues and its cytotoxicity2012
- Author(s)
  Kikuchi, M.; Watanabe, Y.; Tanaka, M.; Akaji, K.; Konno, H.
- Journal Title
  
  Proceedings of 32nd European Peptide Symposium
  
  Pages: 636-637
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21689004
[Journal Article] Structure-based Design, Synthesis, and Evaluation of Peptide-mimetic SARS 3CL Protease Inhibitors2011
- Author(s)
  Akaji, K.; Konno, H.; Mitsui, H.; Teruya, K.; Shimamoto, Y.; Hattori, Y.; Ozaki, T.; Kusunoki, M.; Sanjoh, A
- Journal Title
  
  J. Med. Chem
  
  Volume: 54 Pages: 7962-7937
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590017
[Journal Article] Synthesis of tokaramide A, a cysteine protease inhibitor from marine sponge Theonella mirabilis2011
- Author(s)
  Konno, H.; Nosaka, K.; Akaji, K.
- Journal Title
  
  Tetrahedron
  
  Volume: 67 Issue: 47 Pages: 9067-9071
- DOI
  10.1016/j.tet.2011.09.116
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21689004
[Journal Article] Synthesis and cytotoxicity of callipeltin B analogues2011
- Author(s)
  Kikuchi, M.; Watanabe, Y; Tanaka, M.; Akaji, K.; Konno, H.
- Journal Title
  
  Bioorg. Med. Chem. Lett
  
  Volume: 21 Pages: 4865-4868
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21689004
[Journal Article] Synthesis of Tokaramide A, a Cysteine Protease Inhibitor from Marine Sponge Theonella aff2011
- Author(s)
  Konno, H.; Nosaka, K.; Akaji, K
- Journal Title
  
  Mirabilis. Tetrahedron
  
  Volume: 67 Pages: 9067-9071
- Data Source
  KAKENHI-PROJECT-21590017
[Journal Article] Solid Phase Total Synthesis of Callipeltin E isolated from marine sponge Latrunculia sp.2011
- Author(s)
  Kikuchi, M.; Nosaka, K ; Akaji, K.; Konno, H.
- Journal Title
  
  Tetrahedron Lett.
  
  Volume: 52 Issue: 30 Pages: 3872-3875
- DOI
  10.1016/j.tetlet.2011.05.062
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21689004
[Journal Article] Structure-Based Design, Synthesis, and Evaluation of Peptide-Mimetic SARS 3CL Protease Inhibitors2011
- Author(s)
  Kenichi. Akaji, et.al.
- Journal Title
  
  J.Med.Chem.
  
  Volume: 54 Issue: 23 Pages: 7962-7973
- DOI
  10.1021/jm200870n
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590017, KAKENHI-PROJECT-21689004, KAKENHI-PROJECT-23550195
[Journal Article] Synthesis of N^1- and N^8-(γ-L-Glutamyl) spermidines and (γ-L-Glutamyl) putrescine2011
- Author(s)
  Toho, K.; Abe, N.; Yamada, T.; the late Ito, Y.; Konno, H.; Kuwahara, S.; Kiyota, H.
- Journal Title
  
  Lett.In Org.Chem.
  
  Volume: 8 Issue: 1 Pages: 1-5
- DOI
  10.2174/157017811794557813
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21689004
[Journal Article] Synthetic Study of Cyclodepsipeptide for Anti-HIV agent2011
- Author(s)
  Konno, H.; Kikuchi, M.; Maita, K.; Takatsuka, Y.; Nosaka, K.; Akaji, K.
- Journal Title
  
  Peptide Science 2010
  
  Pages: 200-200
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21689004
[Journal Article] Synthesis and cytotoxicity of the depsipeptides analogues of callipeltin B2011
- Author(s)
  Kikuchi M, Watanabe Y, Tanaka M, Akaji K, Konno H
- Journal Title
  
  Bioorganic & Medicinal Chemistry Letters
  
  Volume: vol 21 Issue: 16 Pages: 4865-4868
- DOI
  10.1016/j.bmcl.2011.06.026
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21500329, KAKENHI-PROJECT-21689004
[Journal Article] Solid Phase Total Synthesis of Callipeltin E isolated from marine sponge Latrunculia sp2011
- Author(s)
  Kikuchi, M.; Nosaka, K.; Akaji, K.; Konno, H.
- Journal Title
  
  Tetrahedron Lett
  
  Volume: 52(30) Pages: 3872-3875
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21689004
[Journal Article] Evaluation of retero-inverso modification of HTLV-1 protease inhibitors containing a hydroxylethyl amine isoster2010
- Author(s)
  Tatsumi, T.; Awahara, C.; Naka, H.; Aimoto, S.; Konno, K.; Nosaka, K.; Akaji, K
- Journal Title
  
  Bioorg Med. Chem
  
  Volume: 18 Pages: 2720-2727
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590017
[Journal Article] Evaluation of Retro-Inverso Modifications of HTLV-1 Protease Inhibitors containing a Hydroxyethylamine Isoster2010
- Author(s)
  Tatsumi, T.; Awahara, C.; Naka, H.; Aimoto, S.; Konno, H.; Nosaka, K.; Akaji, K.
- Journal Title
  
  Bioorg.Med.Chem.
  
  Volume: 18 Pages: 2720-2727
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21689004
[Journal Article] Synthesis of solamin type mono-THF acetogenins using cross-methathesis2010
- Author(s)
  Konno, H.; Makabe, H.; Hattori, Y.; Nosaka, K.; Akaji, K
- Journal Title
  
  Tetrahedoron
  
  Volume: 66 Pages: 7946-7953
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590017
[Journal Article] Synthetic Studies on Callipeltins: stereoselective syntheses of (3S, 4R)-3,4-dimethyl-L-pyroglutamic acid and Fmoc-D-allothreonine2010
- Author(s)
  Konno, H.; Takebayashi, Y.; Nosaka, K.; Akaji, K.
- Journal Title
  
  Heterocycles
  
  Volume: 81(1) Pages: 79-89
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21689004
[Journal Article] Synthetic Studies on Callipeltins : stereoselective syntheses of (3S, 4R)-3,4-dimethyl-L-pyroglutamic acid and Fmoc-D-allothreonine2010
- Author(s)
  Konno, H.; Takebayashi, Y.; Nosaka, K.; Akaji, K.
- Journal Title
  
  Heterocycles
  
  Volume: 81 Pages: 79-89
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21689004
[Journal Article] Synthesis of solamin type mono-THF acetogenins using cross-methathesis2010
- Author(s)
  Konno, H.; Makabe, H.; Hattori, Y.; Nosaka, K.; Akaji, K
- Journal Title
  
  Tetrahedron
  
  Volume: 66 Pages: 7946-7953
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590017
[Journal Article] Synthesis of solamin type mono-THF acetogenins using cross-metathesis2010
- Author(s)
  Konno, H.; Makabe, H.; Hattori, Y.; Nosaka, K.; Akaji, K
- Journal Title
  
  Tetrahedron
  
  Volume: 66 Pages: 7946-7953
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21689004
[Journal Article] Synthesis of Annonacin isolated from Annona densicoma2010
- Author(s)
  Oasa, M.; Hattori, Y.; Konno. H.; Makabe, H.
- Journal Title
  
  Biosci.Biocbem.Biotechnol.
  
  Volume: 74 Pages: 1274-1275
- NAID
  10027556575
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21689004
[Journal Article] Synthetic studies on callipeltins : Stereoselective syntheses of(3S, 4R)-3, 4-Dimethyl-L-pyroglutamic acid and Fmoc-D-allothreonine from serine derivatives2010
- Author(s)
  Konno, K.; Takebayashi, Y.; Nosaka, K.; Akaji, K
- Journal Title
  
  Heterocycles
  
  Volume: 81 Pages: 79-89
- NAID
  40016913697
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590017
[Journal Article] Synthetic studies on callipeltins : Stereoselective syntheses of(3S,4R)-3,4-Dimethyl-L-pyroglutamic acid and Fmoc-D- allothreonine from serine derivatives2010
- Author(s)
  Konno, K.; Takebayashi, Y.; Nosaka, K.; Akaji, K
- Journal Title
  
  Heterocycles
  
  Volume: 81 Pages: 79-89
- NAID
  40016913697
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590017
[Journal Article] Evaluation of retero-inverso modification of HTLV-1 protease inhibitors containing a hydroxyethylamine isoster2010
- Author(s)
  Tatsumi, T.; Awahara, C.; Naka, H.; Aimoto, S.; Konno, K.; Nosaka, K.; Akaji, K
- Journal Title
  
  Bioorg.Med.Chem
  
  Volume: 18 Pages: 2720-2727
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590017
[Journal Article] Synthesis of[19.35.36-^<13>C_3]-Labeled TAK779 as a moleculer probe2009
- Author(s)
  Konno. H., Aimoto, S., Smith, S.O., Nosaka, K., Akaji, K.
- Journal Title
  
  Bioorg.Med.Chem. 17
  
  Pages: 5769-5774
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21689004
[Journal Article] A Concise Synthesis of Solamin and cis-Solamin, Mono-THF Acetogenins from Annona muricata2009
- Author(s)
  Makabe, H., Kuwabara, A., Hattori, Y., Konno, H.
- Journal Title
  
  Heterocycles 78(9)
  
  Pages: 2369-2376
- NAID
  120007106123
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21689004
[Journal Article] Synthesis of [19,35,36-13C3]-labeled TAK779 as a Molecular Probe2009
- Author(s)
  Konno H, Aimoto S, Smith S.O, Nosaka K, Akaji K
- Journal Title
  
  Bioorg.Med.Chem 17
  
  Pages: 5769-5774
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590017
[Journal Article] Synthesis of [19.35.36-C^^<13>__3]-Labeled TAK779 moleculerprobe2009
- Author(s)
  Konno, H.; Aimoto, S.; Smith, S. O.; Nosaka, K.; Akaji, K.
- Journal Title
  
  Bioorg.Med.Chem
  
  Volume: 17 Pages: 5769-5774
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21689004
[Journal Article] Synthesis of [19, 35, 36-13C3]-labeled TAK779 as a Molecular Probe.2009
- Author(s)
  Konno H, ; Aimoto S, ; Smith SO, ; Nosaka K, ; Akaji K
- Journal Title
  
  Bioorg Med. Chem
  
  Volume: 17 Pages: 5769-5774
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590017
[Journal Article] Evaluation of Lipid-Binding Propahes of the N-Terminal Helical Segment8 in Human Apohpoprotein A-I Using Fragment Peptides2009
- Author(s)
  Tanaka, M., Tanaka, T., Ohta, S., Kawakami, T., Konno, H., Akaji, K., Aimoto, S., Saito, H.
- Journal Title
  
  J.Peptide Sci. 15(1)
  
  Pages: 36-42
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21689004
[Journal Article] Evaluation of Lipid-Binding Propaties of the N-Terminal Helical Segments in Human Apolipoprotein A-I Using Fragment Peptides2008
- Author(s)
  Tanaka, M.; Tanaka, T.; Ohta, S.; Kawakami, T.; Konno, H.; Akaji, K.; Aimoto, S.; Saito, H
- Journal Title
  
  J. Peptide Sci 15(1)
  
  Pages: 36-42
- Data Source
  KAKENHI-PROJECT-19790095
[Journal Article] Involvement of Thiaminase II Encoded by the THI20 Gene in Thiamin Salvage of Saccharomyces cerevisiae2008
- Author(s)
  Onozuka, M, et. al.
- Journal Title
  
  FEMS Yeast Research 8
  
  Pages: 266-275
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18580095
[Journal Article] Synthesis of Pyranicin and its Inhibitory Action with Bovine Heart Mitochondrial Complex2008
- Author(s)
  Hattori, N.; Furuhata, S.; Okajima, M.; Konno, H.; Abe, M.; Miyoshi, H.; Goto, T, Makabe, H
- Journal Title
  
  I. Org. Lett 10(5)
  
  Pages: 717-720
- Data Source
  KAKENHI-PROJECT-19790095
[Journal Article] Thiamin-dependent transactivation activity of PDC2 in Saccharomyces2008
- Author(s)
  Nosaka, K. ; Onozuka, M. ; Konno, H. ; Al
- Journal Title
  
  FEBS Lett. 582
  
  Pages: 3991-3996
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19790095
[Journal Article] Total synthesis of pyranicin and its deoxygenated analogues and their inhibitory action with bovine heart mitochondrial complex2008
- Author(s)
  Furuhata, S.; Hattori, Y.; Okajima, M.; Konno, H.; Abe, M.; Miyoshi, H.; Goto, T.; Makabe, H
- Journal Title
  
  I. Tetrahedron 64
  
  Pages: 7695-7703
- Data Source
  KAKENHI-PROJECT-19790095
[Journal Article] Total synthesis of cis-solamin A, a mono-tetrahydrofuran acetogenin isolated from Annona muricata2008
- Author(s)
  Konno, H. ; Okuno, Y. ; Makabe, H. ; Nos
- Journal Title
  
  Tetrahedron Lett. 49
  
  Pages: 782-785
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19790095
[Journal Article] Thiamin-dependent transactivation activity of PDC2 in Saccharomyces2008
- Author(s)
  Nosaka, K.; Onozuka, M.; Konno, H.; Akaji, K
- Journal Title
  
  FEBS Lett 582(29)
  
  Pages: 3991-3996
- Data Source
  KAKENHI-PROJECT-19790095
[Journal Article] Involvement of Thiaminase II Encoded by the THI20 Gene in Thiamin Salvage of Saccharomyces cerevisiae2008
- Author(s)
  Onozuka M
- Journal Title
  
  FEMS Yeast Research 8
  
  Pages: 266-275
- Description
  「研究成果報告書概要(和文)」より
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18580095
[Journal Article] Evaluation of Peptide Aldehyde Inhibitors using R188I Mutant of SARS 3CL Protease as aproteolysis-resistant mutant2008
- Author(s)
  Akaji, K.; Konno, H.; Onozuka, M.; Makino, A.; Nosaka, K
- Journal Title
  
  Bioorg. Med. Chem 16
  
  Pages: 9400-9408
- Data Source
  KAKENHI-PROJECT-19790095
[Journal Article] Total synthesis of cis-solamin A, a mono-tetrahydrofuran acetogenin isolated from Annona muricata2008
- Author(s)
  Konno, H.; Okuno, Y.; Makabe, H.; Nosaka, K.; Onishi, A.; Abe, N.; Sugimoto, A.; Akaji, K
- Journal Title
  
  Tetrahedron Lett 49(5)
  
  Pages: 782-785
- Data Source
  KAKENHI-PROJECT-19790095
[Journal Article] Possible involvement of thiaminase II encoded bythe THI20 gene in thiamine salvage ofSaccharomyces cerevisiae2008
- Author(s)
  Onozuka, M.; Konno, H.; Kawasaki, Y.; Akaji, K.; Nosaka, K
- Journal Title
  
  J. FEMS Yeast Research 8(2)
  
  Pages: 266-275
- Data Source
  KAKENHI-PROJECT-19790095
[Journal Article] Evaluation of Peptide Aldehyde Inhibitors using R1881 Mutant of SARS 3CL Protease as a proteolysi2008
- Author(s)
  Akaji, K. ; Konno, H. ; Onozuka, M. ; Mak
- Journal Title
  
  Bioorg. Med. Chem. 16
  
  Pages: 9400-9408
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19790095
[Journal Article] Studies on Substrate Specificity at PR/p3 Cleavage Site of HTVL-1 Protease2007
- Author(s)
  Bang, J. K.; Teruya, K.; Aimoto, S.; Konno, H.; Nosaka, K.; Tatsumi, T.; Akaji, K.
- Journal Title
  
  Int. J. Peptide Res. 13
  
  Pages: 173-179
- Data Source
  KAKENHI-PROJECT-19790095
[Journal Article] Synthesis of (17S, 18S)-and (17R, 18R)-tonkinelin and their inhibitory action with bovine heart mitochondorial complex2007
- Author(s)
  Hattori, Y.; Konno, H.; Abe, M.; Miyoshi, H.; Goto, T.; Makabe, H.
- Journal Title
  
  I. Bioorg. Med. Chem 15
  
  Pages: 3026-3031
- Data Source
  KAKENHI-PROJECT-19790095
[Journal Article] Synthesis,determination of the absolute configuration of tonkinelin and inhibitory action with bovine heart mitochondrial complex I2007
- Author(s)
  Hattori, Y.; Konno, H.; Abe, M.; Miyoshi, H.; Goto, T; Makabe, H.
- Journal Title
  
  Bioorg.Med.Chem 15
  
  Pages: 3026-3031
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19790095
[Journal Article] Total Synthesis of Miraziridine A and Identification of Its Major Reaction Site for Cathepsin B2007
- Author(s)
  Konno H
- Journal Title
  
  Tetrahedron 63
  
  Pages: 9502-9513
- Description
  「研究成果報告書概要(和文)」より
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18590010
[Journal Article] Synthesis of All Stereoisomers of β-Methoxy Tyrosine Derivatives and Identification of the Absolute Configration in Callipeltin2007
- Author(s)
  Konno, H.; Aoyama, S.; Nosaka, K.; Akaji, K
- Journal Title
  
  E, Synthesis (23)
  
  Pages: 3666-3672
- Data Source
  KAKENHI-PROJECT-19790095
[Journal Article] Total Synthesis of Miraziridine A and Identification of Its Major Reaction Site for Cathepsin B2007
- Author(s)
  Konno, H
- Journal Title
  
  Tetrahedron 63
  
  Pages: 9502-9513
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18590010
[Journal Article] Stereoselective Synthesis of All Stereoisomers of β-Methoxy Tyrosine Derivatives for Identification of the Absolute Configuration in Callipeltin E2007
- Author(s)
  Konno, H.; Aoyama, S.; Nosaka, K; Akaji, K
- Journal Title
  
  Synthesis 23
  
  Pages: 3666-3672
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19790095
[Journal Article] Total synthesis of miraziridine A and identification of major reaction site for cathepsin B2007
- Author(s)
  Konno, H.; Kubo, K.; Makabe, H.; Toshiro, E.; Hinoda, N.; Nosaka, K.; Akaji, K
- Journal Title
  
  Tetrahedron 63(38)
  
  Pages: 9502-9513
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19790095
[Journal Article] Synthesis of Miraziridine A and Identification of Its Major Reactive Site for Cathepsin2007
- Author(s)
  Konno, H.; Kubo, K.; Makabe, H.; Toshiro, E.; Nosaka, K.; Akaji, K. Total
- Journal Title
  
  B. Tetrahedron 63(38)
  
  Pages: 9502-9513
- Data Source
  KAKENHI-PROJECT-19790095
[Journal Article] Synthesis of (4R, 15R, 16R, 21S)-and (4R, 15R, 16R, 21S)-rollicosin and squamostolide, and their inhibitory action with bovine heart mitochondeial complex I.2006
- Author(s)
  Makabe, H., Kimura, Y., Higuchi, M., Konno, H., Murai, M., Miyoshi, H.
- Journal Title
  
  Bioorganic and Medicinal Chemistry 14・9
  
  Pages: 3119-3130
- Data Source
  KAKENHI-PROJECT-16790084
[Journal Article] Synthesis of Murisolin, (15R, 16R, 19R, 20S)-Murisolin-A, (15R, 16R, 19R, 20S)-16, 19-cis-Murisokin-A, and Their Inhibitory Action with Bovine Heart Mitochondrial Complex I.2006
- Author(s)
  Hattori, Y., Kimura, Y., Moroda, A., Konno, H., Abe, M., Miyoshi, H., Goto, T., Makabe, H.
- Journal Title
  
  Chemistry-Asian Journal 1・6
  
  Pages: 894-904
- Data Source
  KAKENHI-PROJECT-16790084
[Journal Article] Evaluations of Substrate Specificity and Inhibition at PR/p3 Cleavage Site of HTLV-1 Protease.2006
- Author(s)
  Naka, H., Teruya, K., Bang, J.K., Aimoto, S., Tatsumi, T., Konno, H., Nosaka, K., Akiji, K.
- Journal Title
  
  Bioorganic and Medicinal Chemistry Letters 16・14
  
  Pages: 3761-3764
- Data Source
  KAKENHI-PROJECT-16790084
[Journal Article] Synthetic Studies of Tokaramide A and Miraziridine A Isolated from Marine Sponge Theonella aff. mirabilis.2006
- Author(s)
  Konno, H., Kubo, K., Makabe, H., Fujii, N., Nosaka, K., Akaji, K.
- Journal Title
  
  Peptide Sciences
  
  Pages: 47-50
- NAID
  10017675327
- Data Source
  KAKENHI-PROJECT-16790084
[Journal Article] First Synthesis of Trans- and Cis-Dendrochrysanines.2006
- Author(s)
  Konno H.
- Journal Title
  
  Heterocycles 68・12
  
  Pages: 2579-85
- NAID
  40015181995
- Data Source
  KAKENHI-PROJECT-18580095
[Journal Article] First syntheses of Trans-and Cis-dendrochrysanines.2006
- Author(s)
  Konno, H., Kusumoto, S., Kanai, S., Yamahana, Y., Nosaka, K., Akaji, K.
- Journal Title
  
  Heterocycles 68・12
  
  Pages: 2579-2585
- Data Source
  KAKENHI-PROJECT-16790084
[Journal Article] First synthesis of trans- and cis-dendrochrysanines2006
- Author(s)
  Hiroyuki Konno
- Journal Title
  
  Heterocycles 68
  
  Pages: 2579-2585
- NAID
  40015181995
- Data Source
  KAKENHI-PROJECT-18590010
[Journal Article] Synthetic studies on miraziridine A, a cysteine protease inhibitor isolated from Theonella aff. mirabilis2006
- Author(s)
  Hiroyuki Konno
- Journal Title
  
  Peptide Science 2006
  
  Pages: 37-38
- NAID
  10020528846
- Data Source
  KAKENHI-PROJECT-18590010
[Journal Article] Molecular Cloning and Analysis of the 5'-Flanking Region of the Human Thiamin Pyrophosphokinase gene.2005
- Author(s)
  Onozuka, M., Konno, H., Akaji, K., Nishino, H., Nosaka, K.;
- Journal Title
  
  J.Nutr.Sci.Vitaminol. 51・4
  
  Pages: 274-277
- NAID
  110002704076
- Data Source
  KAKENHI-PROJECT-16790084
[Journal Article] Genetic regulation mediated by thiamin pyrophosphate-binding motif in Saccharomyces cerevisiae2005
- Author(s)
  Nosaka K., Onozuka, M., Konno, H., Kawasaki, Y., Nishino H., Sano, M., Akaji, K.;
- Journal Title
  
  Mol.Microbiol. 58・2
  
  Pages: 467-479
- Data Source
  KAKENHI-PROJECT-16790084
[Journal Article] Synthesis of (4R,15R,16R,21S)-and (4R,15S,16S,21S)-rollicosin.2005
- Author(s)
  Makabe H., Higuchi, M., Konno, H., Murai, M., Miyoshi, H.;
- Journal Title
  
  Tetrahedron Lett. 46
  
  Pages: 4671-4675
- Data Source
  KAKENHI-PROJECT-16790084
[Journal Article] Solid-Phase Synthesis of Olefin-containing Inhibitors for HTLV-1 Protease using the Horner-Emmons Reaction.2005
- Author(s)
  Bang, J.K., Naka, H., Teruya, K., Aimoto, S., Konno, H., Nosaka, K., Akaji, K.;
- Journal Title
  
  J.Org.Chem. 70・25
  
  Pages: 10596-10599
- Data Source
  KAKENHI-PROJECT-16790084
[Journal Article] Molecular Cloning and Analysis of the 5'-Flanking Region of the Human Thiamin Pyrophosphokinase gene2005
- Author(s)
  Onozuka, M., Konno, H., Akaji, K., Nishino, H., Nosaka, K.
- Journal Title
  
  J. Nutr. Sci, Vitaminol (印刷中)
- NAID
  110002704076
- Data Source
  KAKENHI-PROJECT-16790084
[Journal Article] Synthesis of cis-Solamin and Its Inhibitory Action with Mitochondrial Complex I2004
- Author(s)
  Makabe, H., Hattori, Y., Kimura, Y., Konno, H., Abe, M., Miyoshi, H., Tanaka, A.
- Journal Title
  
  Tetrahedron 60
  
  Pages: 10651-10657
- Data Source
  KAKENHI-PROJECT-16790084
[Journal Article] Synthesis and Mitochondrial Inhibition of Dihydroxy-Cohibin A, Non-THF Annonaceous Acetogenin Analogue2004
- Author(s)
  Konno, H., Hiura, N., Manabe, H., Abe, M., Miyoshi, H.
- Journal Title
  
  Bioorg. Med. Chem. Lett. 13
  
  Pages: 629-632
- Data Source
  KAKENHI-PROJECT-16790084
[Patent] クルクミン誘導体2017
- Inventor(s)
  今野博行
- Industrial Property Rights Holder
  今野博行
- Industrial Property Rights Type
  特許
- Filing Date
  2017-02-23
- Data Source
  KAKENHI-PROJECT-16K07709
[Presentation] Synthesis and evaluation of phthalimide type inhibitors against SARS-CoV 3CL protease2024
- Author(s)
  佐野陽菜, 遠藤龍生, 照屋健太, 服部恭尚, 矢野成和, 今野博行
- Organizer
  日本農芸化学会2024年会
- Data Source
  KAKENHI-PROJECT-22K19125
[Presentation] SARS-CoV 3CL proteaseを標的としたフタルイミド型阻害剤の合成研究2024
- Author(s)
  佐野陽菜、遠藤龍生、照屋健太、服部恭尚、矢野成和、今野博行
- Organizer
  日本農芸化学会2024年度大会
- Data Source
  KAKENHI-PROJECT-21K05417
[Presentation] Synthesis ans structural elucidaton of antatollamide A and its derivatives2024
- Author(s)
  Yitong Li,Keigo Takahmatsu, Hiroyuki Konno
- Organizer
  日本農芸化学会2024年会
- Data Source
  KAKENHI-PROJECT-22K19125
[Presentation] Design, Synthesis and Evaluation of NHPI-based SARS-CoV 3CL Protease Inhibitors2023
- Author(s)
  Ryusei Endo, Hinata Sano, Koki Makabe, Shigekazu Yano, Yasunao Hattori, Kenta Teruya and Hiroyuki Konno
- Organizer
  The 60th Japanese Peptide Symposium Schedule
- Data Source
  KAKENHI-PROJECT-21K05417
[Presentation] フタルイミド型SARS-CoV 3CL protease阻害剤の構造活性相関研究2023
- Author(s)
  佐野陽菜、及川慧人、遠藤龍生、照屋健太、服部恭尚、赤路健一、矢野成和、今野博行
- Organizer
  日本農芸化学会2023年度大会
- Data Source
  KAKENHI-PROJECT-21K05417
[Presentation] Reversible detection method of amino groups during Fmoc-solid phase peptide synthesis2023
- Author(s)
  Hioyuki Konno
- Organizer
  Asai-Pacific international symposium on microscale separations and analysis 2023
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K19125
[Presentation] 細菌型α-1,3-グルカナーゼを用いたニゲロオリゴ糖生産2019
- Author(s)
  矢野成和，玉木友理，小黒夏樹，今野博行，若山　守
- Organizer
  日本農芸化学会2019年度大会
- Data Source
  KAKENHI-PROJECT-17K07708
[Presentation] システイン検出試薬及びジスルフィド架橋剤としてのポリオキソメタレートの応用研究2018
- Author(s)
  休石悠人, 矢野成和, 今野博行
- Organizer
  第8回化学フェスタ
- Data Source
  KAKENHI-PROJECT-16K07709
[Presentation] Synthesis of fluorescent antagonists as molecular probes for CCR5 binding assays2018
- Author(s)
  齋藤拓也, 山口諒平, 東海林由憲, 横山智哉子, 今野博行
- Organizer
  化学系学協会東北大会
- Data Source
  KAKENHI-PROJECT-16K07709
[Presentation] ON/OFF機構により蛍光を制御するAβ凝集体検出のための新規クルクミン型蛍光プローブの探索2018
- Author(s)
  穂積真由美, 佐藤多記, 田尻美理, 今野博行
- Organizer
  第26回山形分子生物学セミナー
- Data Source
  KAKENHI-PROJECT-16K07709
[Presentation] 新規アルツハイマー病治療薬の開発を目指したBerberineの合成研究2018
- Author(s)
  山田亮, 今野博行
- Organizer
  日本農芸化学会東北北海道合同支部会
- Data Source
  KAKENHI-PROJECT-16K07709
[Presentation] 含窒素複素環式天然物Anibamineの合成を指向した新規ピリジン合成法の開発2018
- Author(s)
  宮腰建, 今野博行
- Organizer
  第35回有機合成化学セミナー
- Data Source
  KAKENHI-PROJECT-16K07709
[Presentation] 新しいFmoc化剤Fmoc-OPhthの開発2017
- Author(s)
  今野博行, 吉野諒, 東海林由憲
- Organizer
  日本農芸化学会東北支部会
- Data Source
  KAKENHI-PROJECT-16K07709
[Presentation] Aβ凝集体特異的に結合し機能を発揮するクルクミン誘導体の開発2017
- Author(s)
  佐藤多記, 二階堂由莉, 穂積真由美, 照屋健太, 今野博行
- Organizer
  認知症を知る若手研究者の集まり
- Data Source
  KAKENHI-PROJECT-16K07709
[Presentation] Synthetic study of cyclic depsi-peptide isolated from marine sponge2017
- Author(s)
  Hiroyuki Konno
- Organizer
  Invited Lecture of Joint Symposium of Tohoku University & Dalian University
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K07709
[Presentation] Total synthesis of callipeltin B, Peptydyl Marine Natural Product2017
- Author(s)
  Hiroyuki Konno
- Organizer
  Invited Lecture of Dalian University
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K07709
[Presentation] Synthesis of Secretoglobin 3A2 fragments using Dawson resin by Native.2017
- Author(s)
  菊池真梨子, 黒谷玲子, 今野博行
- Organizer
  日本化学会東北支部大会
- Data Source
  KAKENHI-PROJECT-15K09208
[Presentation] Development of curcumin analogues: detection of Aβ fibrils and its aggregation inhibition2017
- Author(s)
  佐藤多記, 穂積真由美, 今野博行
- Organizer
  第54回ペプチド討論会
- Data Source
  KAKENHI-PROJECT-16K07709
[Presentation] アミロイドβ凝集体に特異的に結合するクルクミン様物質の開発2017
- Author(s)
  今野博行, 二階堂由莉, 佐藤多記
- Organizer
  日本農芸化学会2017年度大会
- Place of Presentation
  京都女子大学
- Year and Date
  2017-03-18
- Data Source
  KAKENHI-PROJECT-16K07709
[Presentation] Aβ凝集体検出色素クルクミンアナログの開発2016
- Author(s)
  佐藤多記, 二階堂由莉, 山田亮, 今野博行
- Organizer
  第48回若手ペプチド夏の勉強会
- Place of Presentation
  八王子市大学セミナーハウス
- Year and Date
  2016-07-31
- Data Source
  KAKENHI-PROJECT-16K07709
[Presentation] Amyloid β に特異的に結合し構造制御するクルクミン様物質の開発2016
- Author(s)
  二階堂由莉, 佐藤多記, 今野博行
- Organizer
  第27回万有仙台シンポジウム
- Place of Presentation
  仙台国際センター
- Data Source
  KAKENHI-PROJECT-16K07709
[Presentation] Aβ凝集体特異的に結合し蛍光を発するクルクミン誘導体の開発2016
- Author(s)
  佐藤多記, 二階堂由莉, 山田亮, 今野博行
- Organizer
  認知症を知る若手研究者の集まり
- Place of Presentation
  ニューサンピア高崎
- Year and Date
  2016-07-30
- Data Source
  KAKENHI-PROJECT-16K07709
[Presentation] アミロイドβ凝集体に特異的に結合するクルクミン様物質の開発2016
- Author(s)
  今野博行, 二階堂由莉, 佐藤多記
- Organizer
  第24回山形分子生物学セミナー
- Place of Presentation
  山形大学農学部
- Data Source
  KAKENHI-PROJECT-16K07709
[Presentation] ミロイド β 凝集体を検出するクルクミン型蛍光プローブの開発2016
- Author(s)
  佐藤多記, 二階堂由莉, 今野博行
- Organizer
  第53回ペプチド討論会
- Place of Presentation
  京都テルサ
- Year and Date
  2016-10-26
- Data Source
  KAKENHI-PROJECT-16K07709
[Presentation] Amyloid β に特異的に結合し構造制御するクルクミン様物質の開発2016
- Author(s)
  今野博行
- Organizer
  日本食品科学工学会年会
- Place of Presentation
  名城大学
- Year and Date
  2016-08-25
- Invited
- Data Source
  KAKENHI-PROJECT-16K07709
[Presentation] Callipeltin B, EおよびMの全合成と細胞毒性評価2015
- Author(s)
  菊池真理, 今野博行
- Organizer
  第26回万有仙台シンポジウム
- Place of Presentation
  仙台国際センター
- Year and Date
  2015-06-06
- Data Source
  KAKENHI-PROJECT-25450145
[Presentation] Total synthesis of callipeltin B2015
- Author(s)
  Konno, H.; Kikuchi, M.
- Organizer
  7th International Peptide Symposium
- Place of Presentation
  Biopolis, Singapore（シンガポール）
- Year and Date
  2015-12-09
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25450145
[Presentation] 環状デプシペプチドcallipeltin Bの全合成と細胞毒性評価2015
- Author(s)
  今野博行, 菊池真理
- Organizer
  日本農芸化学会東北支部会
- Place of Presentation
  東北大学農学部
- Year and Date
  2015-10-03
- Data Source
  KAKENHI-PROJECT-25450145
[Presentation] Callipeltin Bの全合成2015
- Author(s)
  今野博行
- Organizer
  第47回若手ペプチド夏の勉強会
- Place of Presentation
  アスティかたおか
- Year and Date
  2015-08-09
- Invited
- Data Source
  KAKENHI-PROJECT-25450145
[Presentation] 抗HIV活性を有する環状ペプチド homophymine B の合成研究：異常アミノ酸の合成と環状部の構築2015
- Author(s)
  吉野諒, 東海林由, 菊池真理, 武田祥, 今野博行
- Organizer
  第47回若手ペプチド夏の勉強会
- Place of Presentation
  アスティかたおか
- Year and Date
  2015-08-09
- Data Source
  KAKENHI-PROJECT-25450145
[Presentation] Callipeltin Bの合成研究：環化部位の探索2014
- Author(s)
  菊池真理, 今野博行
- Organizer
  日本農芸化学会2014年度大会
- Place of Presentation
  明治大学、川崎市
- Data Source
  KAKENHI-PROJECT-25450145
[Presentation] Homophymine Aの全合成を目指した立体選択的異常アミノ酸の合成と環状部構築のアプローチ2014
- Author(s)
  東海林由憲, 武田祥, 菊池真理, 今野博行
- Organizer
  日本農芸化学会2014年度大会
- Place of Presentation
  明治大学、川崎市
- Data Source
  KAKENHI-PROJECT-25450145
[Presentation] 異常アミノ酸含有環状ペプチド誘導体の合成と構造活性相関2014
- Author(s)
  今野博行
- Organizer
  日本農芸化学会中部支部創立60周年記念若手シンポジウム
- Place of Presentation
  信州大学農学部（長野県南箕輪村）
- Year and Date
  2014-11-22
- Invited
- Data Source
  KAKENHI-PROJECT-25450145
[Presentation] 抗 HIV活性を有する phomophymine Aの合成研究:異常アミノ酸部の合成2013
- Author(s)
  ○武田祥 ,菊池真理 ,米田翔 ,今野博行
- Organizer
  日本農芸化学会 2013年度大会
- Place of Presentation
  東北大学川内キャンパス(宮城県)
- Year and Date
  2013-03-25
- Data Source
  KAKENHI-PROJECT-21689004
[Presentation] Synthetic study on homophymine A: stereoselective synthesis of unusual amino acids2013
- Author(s)
  ○Takeda, S.; Maita, K.; Tokairin, Y.; Konno, H.
- Organizer
  UK/Japan Conference in Catalytic Asymmetric Synthesis
- Place of Presentation
  仙台国際センター(宮城県)
- Year and Date
  2013-04-19
- Data Source
  KAKENHI-PROJECT-21689004
[Presentation] Callipeltin Bの全合成研究2013
- Author(s)
  今野博行, 菊池真理, 菊地唯, 朱秀梅, 赤路健一
- Organizer
  第52回天然有機化合物討論会
- Place of Presentation
  同志社大学、京都市
- Data Source
  KAKENHI-PROJECT-25450145
[Presentation] 異常アミノ酸含有ペプチドのデザインと疾患関連蛋白質阻害剤の創製2013
- Author(s)
  ○今野博行
- Organizer
  日本農芸化学会フロンティアシンポジウム
- Place of Presentation
  秋湯クレセントホテル(宮城県)
- Year and Date
  2013-03-28
- Data Source
  KAKENHI-PROJECT-21689004
[Presentation] 異常アミノ酸含有直鎖ペプチド callipeltin Mの固相全合成2013
- Author(s)
  ○菊池真理 ,今野博行
- Organizer
  日本農芸化学会 2013年度大会
- Place of Presentation
  東北大学川内キャンパス(宮城県)
- Year and Date
  2013-03-25
- Data Source
  KAKENHI-PROJECT-21689004
[Presentation] Synthetic study on homophymine A: stereoselective synthesis of unusual amino acids. UK/Japan Conference in Catalytic Asymmetric Synthesis2013
- Author(s)
  Takeda, S.; Maita, K.; Tokairin, Y.; Konno, H.
- Organizer
  UK/Japan Conference in Catalytic Asymmetric Synthesis
- Place of Presentation
  仙台国際センター、仙台市
- Data Source
  KAKENHI-PROJECT-25450145
[Presentation] カリペルチンBの合成研究：ジメチルピログルタミン酸4種のジアステレオマーの合成とその立体化学について2013
- Author(s)
  菊池真理、今野博行
- Organizer
  日本農芸化学会東北支部会
- Place of Presentation
  岩手大学、盛岡市
- Data Source
  KAKENHI-PROJECT-25450145
[Presentation] Structure activity relationship study of callipeltin B for the cytotoxic activity2012
- Author(s)
  ○菊池真理 ,今野博行
- Organizer
  第49回ペプチド討論
- Place of Presentation
  鹿児島県民会館(鹿児島県)
- Year and Date
  2012-01-17
- Data Source
  KAKENHI-PROJECT-21689004
[Presentation] callipeltin Bの全合成研究2012
- Author(s)
  ○菊池真理 ,今野博行
- Organizer
  第28回若手研究者の仙台セミナー
- Place of Presentation
  東北大学薬学部(宮城県)
- Year and Date
  2012-12-01
- Data Source
  KAKENHI-PROJECT-21689004
[Presentation] Callipeltin Eの固相全合成2012
- Author(s)
  ○菊池真理 ,野坂和人 ,赤路健一 ,今野博行
- Organizer
  日本農芸化学会 2012年度大会
- Place of Presentation
  京都女子大学(京都府)
- Year and Date
  2012-03-23
- Data Source
  KAKENHI-PROJECT-21689004
[Presentation] Synthetic study of callipeltin B analogues and its cytotoxicity2012
- Author(s)
  Kikuchi, M.; Watanabe, Y.; Tanaka, M.; Akaji, K.; Konno, H.
- Organizer
  32nd European Peptide Symposium
- Place of Presentation
  September 4, 2012, Megaron Athens International Conference Centre (Athens, Greece) J. Pep. Sci
- Data Source
  KAKENHI-PROJECT-21689004
[Presentation] 抗 HIV活性を有する環状デプシペプチド類の全合成研究2012
- Author(s)
  ○米田翔 ,菊池真理 ,武田祥 ,今野博行
- Organizer
  日本農芸化学会東北支部会
- Place of Presentation
  弘前大学農学生命科学部(青森県)
- Year and Date
  2012-10-06
- Data Source
  KAKENHI-PROJECT-21689004
[Presentation] 天然物を範とする疾患関連蛋白質阻害剤の創成研究2011
- Author(s)
  ○今野博行
- Organizer
  日本農芸化学会東北支部
- Place of Presentation
  山形大学農学部(山形県)
- Year and Date
  2011-10-08
- Data Source
  KAKENHI-PROJECT-21689004
[Presentation] Callipeltin Bの全合成研究:モデルペプチドの環化反応2011
- Author(s)
  ○菊池真理 ,米田翔 ,赤路健一 ,今野博行
- Organizer
  日本農芸化学会
- Place of Presentation
  京都女子大学(京都府)
- Year and Date
  2011-03-26
- Data Source
  KAKENHI-PROJECT-21689004
[Presentation] 疾患に関わるシステインプロテアーゼの阻害剤創成研究2011
- Author(s)
  今野博行
- Organizer
  東北大学大学院薬学研究科学術講演会
- Place of Presentation
  東北大学薬学部(招待講演)
- Year and Date
  2011-09-16
- Data Source
  KAKENHI-PROJECT-21689004
[Presentation] Synthetic study of the depsipeptides analogues of callipeltin B and its cytotoxicy2011
- Author(s)
  ○菊池真理 ,渡辺善久 ,田中雅樹 ,赤路健一 ,今野博行
- Organizer
  第48回ペプチド討論会
- Place of Presentation
  札幌コンベンションセンター(北海道)
- Year and Date
  2011-09-28
- Data Source
  KAKENHI-PROJECT-21689004
[Presentation] Synthetic Study of Callipeltin A, An Anti-HIV cyclodepsipeptide isolated from Marine Sponge2010
- Author(s)
  ○Konno, H.; Kikuchi, M.; Maita, K.; Nosaka, K.; Akaji, K.
- Organizer
  Int. Peptide Symposium (IPS5)
- Place of Presentation
  京都国際会館(京都府)
- Year and Date
  2010-12-06
- Data Source
  KAKENHI-PROJECT-21689004
[Presentation] 抗 HIV活性を有する環状デプシペプチドの全合成研究2010
- Author(s)
  今野博行 ,○菊池真理 ,米田翔 ,高塚由美子 ,野坂和人 ,赤路健一
- Organizer
  第43回若手ペプチド夏の勉強会
- Place of Presentation
  ウェルネスパーク五色(兵庫県)
- Year and Date
  2010-08-05
- Data Source
  KAKENHI-PROJECT-21689004
[Presentation] Callipeltin Bの全合成研究 : pyrodiMeGln-D-alloThr(N-MeAla)-OHの合成2010
- Author(s)
  ○今野博行 ,○菊地真理 ,野坂和人 ,赤路健一
- Organizer
  日本農芸化学会
- Place of Presentation
  東京大学駒場キャンパス(東京都)
- Year and Date
  2010-03-28
- Data Source
  KAKENHI-PROJECT-21689004
[Presentation] CCR5阻害剤 TAK779の C^^<13>ラベル体合成2010
- Author(s)
  今野博行 ,○高沼大樹 ,千葉裕己 ,相本三郎 , Steven O. Smith,赤路健一
- Organizer
  日本農芸化学会東北北海道合同支部
- Place of Presentation
  東北大学農学部(宮城県)
- Year and Date
  2010-09-28
- Data Source
  KAKENHI-PROJECT-21689004
[Presentation] 抗 HIV活性を有する環状デプシペプチド類の全合成研究 : β -MeOTyr, β-MeOThrおよびアミノヘプタノール誘導体の合成研究2010
- Author(s)
  今野博行 ,○米田翔 ,菊池真理 ,野坂和人,赤路健一
- Organizer
  日本農芸化学会東北北海道合同支部会
- Place of Presentation
  東北大学農学部(宮城県)
- Year and Date
  2010-09-27
- Data Source
  KAKENHI-PROJECT-21689004
[Presentation] SARS 3CLプロテアーゼ阻害剤創成を目指したペプチドアルデヒドの合成と阻害能評価2010
- Author(s)
  今野博行、石井学、服部恭尚、野坂和人、赤路健一
- Organizer
  日本農芸化学会大会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-21590017
[Presentation] Konno, H. ; Kikuchi, M. ; Maita, K. ; Nosaka, K. ; Akaji, K. ; Synthetic Study of Callipeltin A, An Anti-HIV cyclodepsipeptide isolated from Marine Sponge2010
- Author(s)
  Konno, H.; Kikuchi, M.; Maita, K.; Nosaka, K.; Akaji, K.
- Organizer
  Int.Peptide Symposium (IPS5)
- Place of Presentation
  京都国際会館
- Year and Date
  2010-12-06
- Data Source
  KAKENHI-PROJECT-21689004
[Presentation] 疾患関連蛋白質を標的とした阻害剤の創成研究2010
- Author(s)
  ○今野博行
- Organizer
  第14回山形大学大学院理工学研究科セミナー
- Place of Presentation
  山形大学工学部(山形県)
- Year and Date
  2010-08-31
- Data Source
  KAKENHI-PROJECT-21689004
[Presentation] Synthesis and Evaluation of Small PeptideInhibitors for SARS 3CL Protease2010
- Author(s)
  Hiroyuki Konno, Manabu Ishii, Yasunao Hattori, Kazuto Nosaka, Kenichi Akaji
- Organizer
  5th International Peptide Symposium
- Place of Presentation
  Kyoto, Japan
- Data Source
  KAKENHI-PROJECT-21590017
[Presentation] 疾患に関わるシステインプロテアーゼの阻害剤創成研究2010
- Author(s)
  今野博行
- Organizer
  第43回若手ペプチド夏の勉強会
- Place of Presentation
  兵庫県淡路島ウェルネスパーク五色
- Year and Date
  2010-08-02
- Data Source
  KAKENHI-PROJECT-21689004
[Presentation] 構造解析に基づくSARS 3CL Protease阻害剤の設計とその阻害能評価2010
- Author(s)
  今野博行、石井学、野坂和人、服部恭尚、赤路健一
- Organizer
  東北支部第145回大会
- Place of Presentation
  仙台
- Data Source
  KAKENHI-PROJECT-21590017
[Presentation] 異常アミノ酸含有天然物の合成と機能性分子創成への展開2009
- Author(s)
  今野博行
- Organizer
  第46回ペプチド討論会
- Place of Presentation
  北九州国際会議場(北九州市)
- Year and Date
  2009-11-06
- Data Source
  KAKENHI-PROJECT-21689004
[Presentation] Design of small molecular inhibitor for SARS 3CL protease besed on structure analysis2009
- Author(s)
  Akaji K, Nosaka K, Hattori Y, Mitsui H, Konno H, Kusunoki M, Ozaki T, Sanjo A
- Organizer
  第46回ペプチド討論会
- Place of Presentation
  北九州
- Year and Date
  2009-11-04
- Data Source
  KAKENHI-PROJECT-21590017
[Presentation] SARS 3CLプロテアーゼ阻害に必要なチオール反応性官能基の評価2009
- Author(s)
  三井寛法、高橋麻矢子、今野博行、野坂和人、赤路健一
- Organizer
  日本薬学会第129年会
- Place of Presentation
  京都
- Year and Date
  2009-03-27
- Data Source
  KAKENHI-PROJECT-21590017
[Presentation] 環状デプシペプチド callipeltin Bの固相全合成研究2009
- Author(s)
  今野博行 ,野坂和人 ,赤路健一
- Organizer
  日本薬学会年会
- Place of Presentation
  京都国際会館(京都府)
- Year and Date
  2009-03-27
- Data Source
  KAKENHI-PROJECT-21689004
[Presentation] 異常アミノ酸含有天然物の合成と機能性分子創成への展開2009
- Author(s)
  ○今野博行
- Organizer
  第46回ペプチド討論会
- Place of Presentation
  北九州市国際会議場(福岡県)
- Year and Date
  2009-11-06
- Data Source
  KAKENHI-PROJECT-21689004
[Presentation] 固相法によるペプチドアルデヒド類の実践的合成法の検討2009
- Author(s)
  今野博行、石井学、服部恭尚、野坂和人、赤路健一
- Organizer
  第46回ペプチド討論会
- Place of Presentation
  北九州
- Year and Date
  2009-11-04
- Data Source
  KAKENHI-PROJECT-21590017
[Presentation] 構造解析に基づくペプチドアルデヒド型SARS 3CLプロテアーゼ阻害剤の合成と評価2009
- Author(s)
  今野博行、野坂和人、小野塚真理、三井寛典、赤路健一、楠木正巳、尾崎健、三城明
- Organizer
  第35回反応と合成の進歩シンポジウム
- Place of Presentation
  金沢
- Year and Date
  2009-11-16
- Data Source
  KAKENHI-PROJECT-21590017
[Presentation] Synthestic Studies on Callipeltins B and E isolated form marine sponge2008
- Author(s)
  今野博行、野坂和人、赤路健一
- Organizer
  第45回ペプチド討論会
- Place of Presentation
  東京、船堀タワーホール
- Year and Date
  2008-10-29
- Data Source
  KAKENHI-PROJECT-19790095
[Presentation] 変異型SARS3CLproteaseを用いた新規アルデヒド型阻害剤の評価2008
- Author(s)
  高橋麻矢子、野坂和人、今野博行、赤路健一
- Organizer
  日本薬学会年会、2008年度大会要旨集2
- Place of Presentation
  横浜市、パシフィコ横浜
- Year and Date
  2008-03-29
- Data Source
  KAKENHI-PROJECT-19790095
[Presentation] Synthestic Studies on Callipeltins B and E isolated form marine sponge2008
- Author(s)
  今野博行、野坂和人、赤路健一
- Organizer
  第45回ペプチド討論会
- Place of Presentation
  東京都、船堀タワーホール
- Year and Date
  2008-10-29
- Data Source
  KAKENHI-PROJECT-19790095
[Presentation] レトロインベルソペプチド型HTLV-1プロテアーゼ阻害剤の合成と構造活性相関2008
- Author(s)
  粟原千如、辰巳正、今野博行、野坂和人、赤路健一
- Organizer
  第34回反応と合成の進歩シンポジウム
- Place of Presentation
  京都市、京都テルサ
- Year and Date
  2008-11-04
- Data Source
  KAKENHI-PROJECT-19790095
[Presentation] Syntheses and Evaluations of Peptide based Inhibitors for R188I Mutant of SARS 3CL protease2008
- Author(s)
  三井寛法、高橋真矢子、今野博行、野坂和人、赤路健一
- Organizer
  第45回ペプチド討論会
- Place of Presentation
  東京都、船堀タワーホール
- Year and Date
  2008-10-28
- Data Source
  KAKENHI-PROJECT-19790095
[Presentation] ミトコンドリアComplexIを阻害するアセトゲニンcis-solamin-Aの合成と阻害能に関する研究2008
- Author(s)
  今野博行、奥野康弘、真壁秀文、野坂和人、赤路健一
- Organizer
  日本薬学会年会、2008年度大会要旨集2
- Place of Presentation
  横浜市、パシフィコ横浜
- Year and Date
  2008-03-28
- Data Source
  KAKENHI-PROJECT-19790095
[Presentation] レトロインベルソペプチド型HTLV-1プロテアーゼ阻害剤の合成2008
- Author(s)
  粟原千如、辰巳正、今野博行、野坂和人、赤路健一
- Organizer
  日本薬学会年会、2008年度大会要旨集2
- Place of Presentation
  横浜市、パシフィコ横浜
- Year and Date
  2008-03-29
- Data Source
  KAKENHI-PROJECT-19790095
[Presentation] Evaluation of peptide-based inhibitors using R188I mutant of SARS 3CL protease as aproteolysis-resistant mutant2007
- Author(s)
  赤路健一、今野博行、小野塚真理、齋藤裕行、牧野歩、野坂和人
- Organizer
  第45回ペプチド討論会
- Place of Presentation
  富山市、富山コンベンションセンター
- Data Source
  KAKENHI-PROJECT-19790095
[Presentation] レトロインベルソペプチド型HTLV-1プロテアーゼ阻害剤の合成と構造活性相関2007
- Author(s)
  辰巳正、粟原千如、仲裕美、相本三郎、今野博行、野坂和人、赤路健一
- Organizer
  メディシナルケミストリーシンポジウム
- Place of Presentation
  相模原市、相模原文化センター
- Data Source
  KAKENHI-PROJECT-19790095
[Presentation] Total Synthesis of Miraziridine A and Its Analogues.2007
- Author(s)
  Konno, H.; Kubo, K; Makabe, H.; Nosaka, K; Akaji, K.
- Organizer
  Int. Peptides Sympodium(IPS4)
- Place of Presentation
  Cairns,Australia
- Year and Date
  2007-10-23
- Data Source
  KAKENHI-PROJECT-19790095
[Presentation] Synthesis and structure activity relationship Studies of iraziridine A, a cysteine protease inhibitor2007
- Author(s)
  今野博行、久保佳奈子、真壁秀文、野坂和人、赤路健一
- Organizer
  第45回ペプチド討論会
- Place of Presentation
  富山市、富山コンベンションセンター
- Data Source
  KAKENHI-PROJECT-19790095
[Presentation] ブリックホール2006
- Author(s)
  今野博行、久保佳奈子、真壁秀文、野坂和人、赤路健一
- Organizer
  第33回反応と合成の進歩シンポジウム
- Place of Presentation
  長崎市
- Data Source
  KAKENHI-PROJECT-19790095
[Presentation] 常アミノ酸含有ペプチド callipeltin 類の合成研究: 副産物の解析
- Author(s)
  菊池真理, 今野博行
- Organizer
  日本農芸化学会北海道東北合同支部会
- Place of Presentation
  北海道大学農学部（札幌市）
- Year and Date
  2014-09-22 – 2014-09-23
- Data Source
  KAKENHI-PROJECT-25450145
[Presentation] 海綿由来環状デプシペプチドHomophymine の全合成を目指した異常アミノ酸の立体制御合成
- Author(s)
  吉野諒, 東海林由憲,武田祥,今野博行
- Organizer
  化学系学協会東北大会
- Place of Presentation
  山形大学工学部（米沢市）
- Year and Date
  2014-09-20 – 2014-09-21
- Data Source
  KAKENHI-PROJECT-25450145
[Presentation] アルツハイマー病関連蛋白質を標的とした阻害剤創製研究
- Author(s)
  今野博行
- Organizer
  化学系学協会東北大会有機化学コロキウム
- Place of Presentation
  山形大学工学部（米沢市）
- Year and Date
  2014-09-20 – 2014-09-21
- Invited
- Data Source
  KAKENHI-PROJECT-25450145
[Presentation] Solid phase synthesis of the cyclic fragment of homophymine B
- Author(s)
  東海林由憲, 吉野諒, 武田祥, 今野博行
- Organizer
  第51回ペプチド討論会
- Place of Presentation
  徳島大学薬学部（徳島市）
- Year and Date
  2014-10-22 – 2014-10-24
- Data Source
  KAKENHI-PROJECT-25450145

1. NOSAKA Kazuto (10228314)

# of Collaborated Projects: 4 results

# of Collaborated Products: 16 results
2. Kurotani Reiko (00453043)

# of Collaborated Projects: 3 results

# of Collaborated Products: 2 results
3. 阿部宏之 (10375199)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
4. AKAJI Kenichi (60142296)

# of Collaborated Projects: 2 results

# of Collaborated Products: 18 results
5. 柴田陽光 (60333978)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
6. KUMAKI Nobue (90366021)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. YANO Shigekazu (50411228)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
8. hattori Yasunao (20567028)

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
9. ONO Sotaro

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. KINOSHITA Takamune

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. WATANABE Yoshihisa

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
12. 真壁秀文

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
13. 廣田満

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
14. 田中雅樹

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Konno Hiroyuki 今野 博行

KONNO Hiroyuki 今野 博行

ONOZUKA Mari

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Reversible detection of amino group and protein labeling methodologyPrincipal Investigator

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Design, synthesis and evaluation of curcumin analogues toward amyloid peptide aggregation inhibition and detectionPrincipal Investigator

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Structure activity relationship study of cyclic depsipetide callipeltins with anti-HIV activityPrincipal Investigator

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Design and synthesis of the inhibitors for chemokine receptor CCR5Principal Investigator

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Synthesis and inhibitory activity of cyclic depsi-peptide with anti-HIV activityPrincipal Investigator

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Konno Hiroyuki 今野博行

KONNO Hiroyuki 今野博行