DOI Nobuhide 土居信英

Researcher Number	50327673
Other IDs
External Links
Affiliation (Current)	2022: 慶應義塾大学, 理工学部(矢上), 教授
Affiliation (based on the past Project Information) *help	2017 – 2021: 慶應義塾大学, 理工学部(矢上), 教授 2016: 慶應義塾大学, 理工学部(矢上), 准教授 2010 – 2015: 慶應義塾大学, 理工学部, 准教授 2014: 慶應義塾大学, 理工学部生命情報学科, 准教授 2008: Keio University, 理工学部, 准教授 … More
Review Section/Research Field	Principal Investigator Biofunction/Bioprocess / Biomedical engineering/Biomaterial science and engineering / Biological Sciences / Applied molecular and cellular biology / Evolutionary biology / Applied molecular and cellular biology / Biofunction/Bioprocess / Applied genomics / Basic Section 90120:Biomaterials-related Except Principal Investigator Neurochemistry/Neuropharmacology … More
Keywords	Principal Investigator バイオテクノロジー / 蛋白質 / 進化 / プロテオーム / 免疫学 / 発現制御 / 共焦点顕微鏡 / ライブラリー / 試験管内進化 / 試験管内選択 … More Except Principal Investigator プロテオーム / Proteome / 癌幹細胞 / H. pylori / CAPZA1 / がん幹細胞 / CD44 / Musashi1 / RNA結合タンパク質 / 神経発生 / 神経回路 / 未分化維持 / 翻訳制御 / 転写後制御 / 神経分化 / Musashi / Dcc / Dcx / 分化 / 幹細胞 / 再生医学 / プロテオミクス / マイクロアレイ / プロテインチップ / 蛍光ラベル / 相互作用 / ピューロマイシン / Proteomics / Micro array / Protein Chip / Fluorescence Labeling / Interaction / Puromycin / 選択的スプライシング / 疾患遺伝子 / In vitro virus法 / タンパク質間相互作用 / 遺伝子ネットワーク / バイオインフォマティクス / ハイスループットスクリーニング / 蛋白質間相互作用 / Alternative splicing / Disease-related genes / In vitro virus / Protein-protein interactions / Gene network / Bioinformatics / High-throughput screening / オートファジー / CD44v9 / 一本鎖抗 / 膜透過促進ペプチド / CagA / ペプチド / 低分子抗体 / 膜透過性ペプチド / 酸化ストレス / 抗体 / autophagy / MnSOD / 肝微小環境 / 類洞内皮細胞 / Sema6A / 肝再生 / 線維化 / mucosoid / ペプチド抗体 / 糖鎖 / ムコソイド Less

肝微小環境の構造理解に基づく新たな代謝性肝疾患治療の確立
- Principal Investigator
  
  本多政夫
- Project Period (FY)
  2021 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Review Section
  
  Medium-sized Section 53:Organ-based internal medicine and related fields
- Research Institution
  Kanazawa University
Development of a two-step molecular targeted therapy to eliminate gastric cancer stem cells and progenitor cells
- Principal Investigator
  
  鈴木秀和
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 53010:Gastroenterology-related
- Research Institution
  Tokai University
細胞内の創薬ターゲットに対するがん細胞選択的な膜透過抗体医薬の開発Principal Investigator
- Principal Investigator
  
  土居信英
- Project Period (FY)
  2020 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 90120:Biomaterials-related
- Research Institution
  Keio University
mRNAディスプレイ法による翻訳アレスト配列の大規模探索Principal Investigator
- Principal Investigator
  
  土居信英
- Project Period (FY)
  2017 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
- Review Section
  
  Biological Sciences
- Research Institution
  Keio University
Development of cell-specific DDS for biopharmaceuticals using a novel human-derived membrane penetration-enhancing peptidePrincipal Investigator
- Principal Investigator
  
  DOI Nobuhide
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Biomedical engineering/Biomaterial science and engineering
- Research Institution
  Keio University
Mandatory autophagy induction targeting gastric cancer stem cells by hybrid small molecule antibodies
- Principal Investigator
  
  SUZUKI HIDEKAZU
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Gastroenterology
- Research Institution
  Keio University
Fusogenic peptides combined with pH-dependent antibody fragments for cell-specific intracellular drug deliveryPrincipal Investigator
- Principal Investigator
  
  DOI Nobuhide
- Project Period (FY)
  2015 – 2016
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Biomedical engineering/Biomaterial science and engineering
- Research Institution
  Keio University
mRNAディスプレイ法による翻訳アレスト配列探索技術の開発Principal Investigator
- Principal Investigator
  
  土居信英
- Project Period (FY)
  2015 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
- Review Section
  
  Biological Sciences
- Research Institution
  Keio University
Cell-free display technologies for development of next-generation therapeutic antibody fragmentsPrincipal Investigator
- Principal Investigator
  
  DOI NOBUHIDE
- Project Period (FY)
  2013 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Biofunction/Bioprocess
- Research Institution
  Keio University
Analysis for a neural differentiation regulatory factor, Musashi1
- Principal Investigator
  
  HORISAWA Kenichi
- Project Period (FY)
  2012 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Neurochemistry/Neuropharmacology
- Research Institution
  Kyushu University
  Keio University
Development of an efficient screening technique for oxidoreductases used for biofuel cellsPrincipal Investigator
- Principal Investigator
  
  DOI Nobuhide
- Project Period (FY)
  2012 – 2013
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Biofunction/Bioprocess
- Research Institution
  Keio University
Cell-free display technology for optimization of antibody drugsPrincipal Investigator
- Principal Investigator
  
  DOI Nobuhide
- Project Period (FY)
  2010 – 2012
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Biofunction/Bioprocess
- Research Institution
  Keio University
On-Chip Co-expression Microarrays for Precise Analysis of Transcriptional Regulatory NetworksPrincipal Investigator
- Principal Investigator
  
  DOI Nobuhide
- Project Period (FY)
  2010 – 2011
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Applied molecular and cellular biology
- Research Institution
  Keio University
In vitro selection of novel recombinant antibodiesPrincipal Investigator
- Principal Investigator
  
  DOI Nobuhide
- Project Period (FY)
  2007 – 2008
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Biofunction/Bioprocess
- Research Institution
  Keio University
限定されたアミノ酸からなるランダム配列タンパク質の機能探索Principal Investigator
- Principal Investigator
  
  土居信英
- Project Period (FY)
  2007 – 2008
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  Evolutionary biology
- Research Institution
  Keio University
A large-scale analysis of protein-protein interactions using Escherichia coli proteome chipsPrincipal Investigator
- Principal Investigator
  
  DOI Nobuhide
- Project Period (FY)
  2005 – 2006
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  Applied genomics
- Research Institution
  Keio University
Proteome Analysis of Disease-related Genes based on Alternative Splicing
- Principal Investigator
  
  YANAGAWA Hiroshi
- Project Period (FY)
  2004 – 2007
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  Applied genomics
- Research Institution
  Keio University
進化分子工学によるエストロゲン様物質センサータンパク質の創出Principal Investigator
- Principal Investigator
  
  土居信英
- Project Period (FY)
  2001 – 2002
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Applied molecular and cellular biology
- Research Institution
  Keio University
Protein Microarrays based on C-terminal Labeling of Proteins
- Principal Investigator
  
  YANAGAWA Hiroishi
- Project Period (FY)
  2001 – 2002
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  広領域
- Research Institution
  Keio University

[Book] ドラッグデリバリーシステム - バイオ医薬品創成に向けた組織、細胞内、核内送達技術の開発-2018
- Author(s)
  土居信英
- Total Pages
  280
- Publisher
  シーエムシー出版
- Data Source
  KAKENHI-PROJECT-17H02103
[Book] 医療・診断をささえるペプチド科学 - 再生医療・DDS・診断への応用 -2017
- Author(s)
  土居信英
- Total Pages
  7
- Publisher
  シーエムシー出版
- ISBN
  9784781312675
- Data Source
  KAKENHI-PROJECT-17H02103
[Book] 進化分子工学　～高速分子進化によるタンパク質・核酸の開発～2013
- Author(s)
  土居信英
- Total Pages
  12
- Publisher
  NTS出版
- Data Source
  KAKENHI-PROJECT-24656508
[Book] 進化分子工学による新規タンパク質の創出とプロテオミクスへの応用.「進化分子工学～高速分子進化によるタンパク質・核酸の開発～」(伏見譲編)2013
- Author(s)
  土居信英,柳川弘志
- Publisher
  NTS出版
- Data Source
  KAKENHI-PROJECT-24656508
[Book] 進化分子工学　～高速分子進化によるタンパク質・核酸の開発～2013
- Author(s)
  土居信英
- Total Pages
  12
- Publisher
  NTS出版
- Data Source
  KAKENHI-PROJECT-25289298
[Book] 次世代医薬開発に向けた抗体工学の最前線2012
- Author(s)
  土居信英
- Publisher
  シーエムシー出版
- Data Source
  KAKENHI-PROJECT-22360351
[Book] 現代生物科学入門9:合成生物学2010
- Author(s)
  柳川弘志,土居信英
- Publisher
  岩波書店
- Data Source
  KAKENHI-PROJECT-22360351
[Book] 現代生物科学入門9:合成生物学2010
- Author(s)
  土居信英
- Total Pages
  220
- Publisher
  岩波書店
- Data Source
  KAKENHI-PROJECT-22360351
[Journal Article] Microfluidic screening system based on boron-doped diamond electrodes and dielectrophoretic sorting for directed evolution of NAD(P)-dependent oxidoreductases.2020
- Author(s)
  Goto, H., Kanai, Y., Yotsui, A., Shimokihara, S., Shitara, S., Oyobiki, R., Fujiwara, K., Watanabe, T., Einaga, Y., Matsumoto, Y., Miki, N., Doi, N.
- Journal Title
  
  Lab Chip
  
  Volume: 20 Pages: 852-861
- DOI
  10.1039/c9lc01263j
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17H02103
[Journal Article] Cell-sized confinement controls generation and stability of a protein wave for spatiotemporal regulation in cells.2019
- Author(s)
  Kohyama Shunshi、Yoshinaga Natsuhiko、Yanagisawa Miho、Fujiwara Kei、Doi Nobuhide
- Journal Title
  
  eLife
  
  Volume: 8
- DOI
  10.7554/elife.44591
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PUBLICLY-18H04565, KAKENHI-PROJECT-17H00769, KAKENHI-PROJECT-17H02103, KAKENHI-PROJECT-17K05605, KAKENHI-PROJECT-18H01187
[Journal Article] Regulation of spatiotemporal patterning in artificial cells by a defined protein expression system.2019
- Author(s)
  Yoshida Aoi、Kohyama Shunshi、Fujiwara Kei、Nishikawa Saki、Doi Nobuhide
- Journal Title
  
  Chem. Sci.
  
  Volume: 10 Pages: 11064-11072
- DOI
  10.1039/c9sc02441g
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PUBLICLY-18H04565, KAKENHI-PROJECT-17H02103
[Journal Article] Artificial cell fermentation as a platform for highly efficient cascade conversion.2018
- Author(s)
  Fujiwara Kei、Adachi Takuma、Doi Nobuhide
- Journal Title
  
  ACS Synth. Biol.
  
  Volume: 7 Pages: 363-370
- DOI
  10.1021/acssynbio.7b00365
- Peer Reviewed
- Data Source
  KAKENHI-PUBLICLY-17H05235, KAKENHI-PROJECT-17H02103
[Journal Article] Engineering of DNA polymerase I from Thermus thermophilus using compartmentalized self-replication.2018
- Author(s)
  Aye, S.L., Fujiwara, K., Ueki, A., Doi, N.
- Journal Title
  
  Biochem. Biophys. Res. Commun.
  
  Volume: 499 Pages: 170-176
- DOI
  10.1016/j.bbrc.2018.03.098
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17H02103
[Journal Article] A dual system using compartmentalized partnered replication for selection of arsenic-responsive transcriptional regulator.2018
- Author(s)
  Aye, S.L., Fujiwara, K., Doi, N.
- Journal Title
  
  J. Biochem.
  
  Volume: 164 Pages: 341-348
- DOI
  10.1093/jb/mvy055
- NAID
  40021724808
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17H02103
[Journal Article] ヒト由来膜融合ペプチドによるバイオ医薬のDDS.2017
- Author(s)
  土居信英
- Journal Title
  
  細胞
  
  Volume: 49 Pages: 602-605
- Data Source
  KAKENHI-PROJECT-17H02103
[Journal Article] Human-derived fusogenic peptides for the intracellular delivery of proteins.2017
- Author(s)
  Sudo, K., Niikura, K., Iwaki, K., Kohyama, S., Fujiwara, K., Doi, N.
- Journal Title
  
  J. Control. Release
  
  Volume: 255 Pages: 1-11
- DOI
  10.1016/j.jconrel.2017.03.398
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-15K12545, KAKENHI-PROJECT-17H02103
[Journal Article] In vitro transcription-translation using bacterial genome as a template to reconstitute intracellular profile.2017
- Author(s)
  Fujiwara Kei、Sawamura Tsunehito、Niwa Tatsuya、Deyama Tatsuki、Nomura Shin-ichiro M.、Taguchi Hideki、Doi Nobuhide
- Journal Title
  
  Nucleic Acids Res.
  
  Volume: 45 Pages: 11449-11458
- DOI
  10.1093/nar/gkx776
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PUBLICLY-17H05235, KAKENHI-PUBLICLY-17H05674, KAKENHI-PROJECT-15H02774
[Journal Article] PURE mRNA display for in vitro selection of single-chain antibodies.2016
- Author(s)
  Nagumo, Y., Fujiwara, K., Horisawa, K., Yanagawa, H., Doi, N.
- Journal Title
  
  J. Biochem.
  
  Volume: 159 Pages: 519-526
- DOI
  10.1093/jb/mvv131
- NAID
  40020833577
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-15K12545, KAKENHI-PROJECT-25289298, KAKENHI-PUBLICLY-15H01543
[Journal Article] Endosomal escape efficiency of fusogenic B18 and B55 peptides fused with anti-EGFR single chain Fv as estimated by nuclear translocation.2016
- Author(s)
  Niikura, K., Horisawa, K., Doi, N.
- Journal Title
  
  J. Biochem.
  
  Volume: 159 Pages: 123-132
- DOI
  10.1093/jb/mvv083
- NAID
  40020725715
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-15K12545, KAKENHI-PROJECT-25289298
[Journal Article] Biochemical preparation of cell extract for cell-free protein synthesis without physical disruption.2016
- Author(s)
  K. Fujiwara, N. Doi
- Journal Title
  
  PLoS ONE
  
  Volume: 11
- DOI
  10.1371/journal.pone.0154614
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PUBLICLY-15H00826, KAKENHI-PUBLICLY-15H01543, KAKENHI-PROJECT-15K12545, KAKENHI-PROJECT-26650044
[Journal Article] In vitro selection of bispecific diabody fragments using covalent bicistronic DNA display.2016
- Author(s)
  Nakayama, M., Komiya, S., Fujiwara, K., Horisawa, K., Doi, N.
- Journal Title
  
  Biochem Biophys Res Commun.
  
  Volume: 478 Pages: 606-611
- DOI
  10.1016/j.bbrc.2016.07.113
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-15K12545, KAKENHI-PROJECT-16K08592
[Journal Article] A fusogenic peptide from a sea urchin fertilization protein promotes intracellular delivery of biomacromolecules by facilitating endosomal escape.2015
- Author(s)
  Niikura, K., Horisawa, K., Doi, N.
- Journal Title
  
  J. Control. Release
  
  Volume: 212 Pages: 85-93
- DOI
  10.1016/j.jconrel.2015.06.020
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-15K12545, KAKENHI-PROJECT-25289298
[Journal Article] Structural basis for inhibition of the MDM2:p53 interaction by an optimized MDM2-binding peptide selected with mRNA display2014
- Author(s)
  T. Nagata, K. Shirakawa, N. Kobayashi, H. Shiheido, N. Tabata, Y. Sakuma-Yonemura, K. Horisawa, M. Katahira, N. Doi, H. Yanagawa
- Journal Title
  
  PLoS ONE
  
  Volume: 9
- DOI
  10.1371/journal.pone.0109163
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-23570146, KAKENHI-PROJECT-25289298, KAKENHI-PROJECT-26440026
[Journal Article] MIP-2A is a novel target of an anilinoquinazoline derivative for inhibition of tumour cell proliferation.2013
- Author(s)
  Tokunaga M, Shiheido H, Tabata N, Sakuma-Yonemura Y, Takashima H, Horisawa K, Doi N, Yanagawa H.
- Journal Title
  
  PLoS One.
  
  Volume: 8
- DOI
  10.1371/journal.pone.0076774
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24500447
[Journal Article] Hereditary spastic paraplegia protein spartin is an FK506-binding protein identified by mRNA display.2013
- Author(s)
  Tokunaga M, Shiheido H, Hayakawa I, Utsumi A, Takashima H, Doi N, Horisawa K, Sakuma-Yonemura Y, Tabata N, Yanagawa H.
- Journal Title
  
  Chemistry & Biology
  
  Volume: 20 Pages: 935-942
- DOI
  10.1016/j.chembiol.2013.05.011
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24500447
[Journal Article] DNA display selection of peptide ligands for a full-length human G protein-coupled receptor on CHO-K1 cells2012
- Author(s)
  Doi, N., Yamakawa, N., Matsumoto, H., Yamamoto, Y., Nagano, T., Matsumura, N., Horisawa, K., Yanagawa, H.
- Journal Title
  
  PLoS ONE
  
  Volume: 7
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22658111
[Journal Article] In vitro selection of Fab fragments by mRNA display and gene-linking emulsion PCR2012
- Author(s)
  Sumida, T., Yanagawa, H., Doi, N
- Journal Title
  
  J. Nucleic Acids
  
  Volume: 2012 Pages: 371379-371379
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22360351
[Journal Article] DNA display selection of peptide ligands for a full-length human G protein-coupled receptor on CHO-K1 cells2012
- Author(s)
  Doi,N.,Yamakawa,N.,Matsumoto,H.,Yamamoto,Y.,Nagano,T.,Matsumura,N.,Horisawa,K.,Yanagawa,H.
- Journal Title
  
  PLoS ONE
  
  Volume: 7 Pages: 1-8
- DOI
  10.1371/journal.pone.0030084
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22310121, KAKENHI-PROJECT-22360351, KAKENHI-PROJECT-22658111, KAKENHI-PROJECT-23650271
[Journal Article] DNA display selection of peptide ligands for a full-length human G protein-coupled receptor on CHO-K1 cells2012
- Author(s)
  Doi,N.,Yamakawa,N.,Matsumoto,H.,Yamamoto,Y.,Nagano,T.,Matsumura,N.,Horisawa,K.,Yanagawa,H
- Journal Title
  
  PLoS ONE
  
  Volume: 7
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22360351
[Journal Article] mRNA display selection of an optimized MDM2-binding peptide that potently inhibits MDM2-p53 interaction2011
- Author(s)
  Shiheido, H., Takashima, H., Doi, N., Yanagawa, H
- Journal Title
  
  PLoS ONE
  
  Volume: 6
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22360351
[Journal Article] Comparison of the frequency of functional SH3 domains with different limited sets of amino acids using mRNA display2011
- Author(s)
  Tanaka, J., Yanagawa, H., Doi, N
- Journal Title
  
  PLoS ONE
  
  Volume: 6
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22360351
[Journal Article] Comparative characteriza-tion of random-sequence proteins consisting of 5, 12 and 20 kinds of amino acids2010
- Author(s)
  Tanaka, J., Doi, N., Takashima, H., Yanagawa, H
- Journal Title
  
  Protein Sci
  
  Volume: 19 Pages: 786-795
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22360351
[Journal Article] mRNA display selection of a high-affinity, Bcl-XL-specific binding peptide2010
- Author(s)
  Matsumura, N., Tsuji, T., Sumida, T., Kokubo, M., Onimaru, M., Doi, N., Takashima, H., Miyamoto-Sato, E., Yanagawa, H
- Journal Title
  
  FASEB J
  
  Volume: 24 Pages: 2201-2210
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22360351
[Journal Article] Rapid antibody selection by mRNA display on a microfluidic chip2009
- Author(s)
  Tabata, N., Sakuma, Y., Honda, Y., Doi, N., Takashima, H., Miyamoto-Sato, E., Yanagawa, H.
- Journal Title
  
  Nucleic Acids Res. 37
  
  Pages: 64-64
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19360377
[Journal Article] Use of cDNA tiling arrays for identifying proteininteractions selected by in vitro display technologies2008
- Author(s)
  Horisawa, K., Doi, N., Yanagawa, H.
- Journal Title
  
  PLoS ONE 3
  
  Pages: 1646-1646
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19360377
[Journal Article] Photocleavable linkage between genotype and phenotype for rapid and efficient recovery of nucleic acids encoding affinity-selected proteins2007
- Author(s)
  Doi, N., et. al.
- Journal Title
  
  J. Biotechnol 131
  
  Pages: 231-239
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16201042
[Journal Article] Photocleavable linkage between genotype and phenotype for rapid and efficient recovery of nucleic acids encoding affinity-selected proteins2007
- Author(s)
  Doi, N.
- Journal Title
  
  J.Biotechnol. 131
  
  Pages: 231-239
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16201042
[Journal Article] Photocleavable linkage between genotype and phenotype for rapid and efcient recovery of nucleic acids encoding affinity-selected proteins2007
- Author(s)
  Doi, N.
- Journal Title
  
  J.Biotechnol 131
  
  Pages: 231-239
- Description
  「研究成果報告書概要(和文)」より
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16201042
[Journal Article] Photocleavable linkage between genotype and phenotype for rapid and efficient recovery of nucleic acids encoding affinity-selected proteins2007
- Author(s)
  Doi, N.
- Journal Title
  
  J.Biotechnol. 131
  
  Pages: 231-239
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19360377
[Journal Article] Photocleavable linkage between genotype and phenotype for rapid and efficient recovery of nucleic acids encoding affinity-selected proteins2007
- Author(s)
  Doi, N., Takashima, H., Wada, A., Oishi, Y., Nagano, T., Yanagawa, H.
- Journal Title
  
  J. Biotechnol. 131
  
  Pages: 231-239
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19360377
[Journal Article] Photocleavable linkage between genotype and phenotype for rapid and efficient recovery of nucleic acids encoding affinity-selected Proteins2007
- Author(s)
  Doi, N.
- Journal Title
  
  J.Biotechnol. 131
  
  Pages: 231-239
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19657073
[Journal Article] High-throughput fluorescence labeling of full-length cDNA products based on a reconstituted translation system2007
- Author(s)
  Kawahashi, Y., Doi, N., Oishi, Y., Tsuda, C., Takashima, H., Baba, T., Mori, H., Ito, T., Yanagawa, H.
- Journal Title
  
  J. Biochem. 141
  
  Pages: 19-24
- NAID
  10020101733
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19360377
[Patent] 融合タンパク質又は複合タンパク質，細胞内送達用担体，部分ペプチド，細胞膜透過促進剤，DNA，及びベクター2015
- Inventor(s)
  須藤慧，新倉啓介，土居信英
- Industrial Property Rights Holder
  学校法人慶應義塾
- Industrial Property Rights Type
  特許
- Filing Date
  2015-06-11
- Data Source
  KAKENHI-PROJECT-15K12545
[Patent] 融合タンパク質又は複合タンパク質，細胞内送達用担体，部分ペプチド，細胞膜透過促進剤，DNA，及びベクター2015
- Inventor(s)
  須藤慧，新倉啓介，土居信英
- Industrial Property Rights Holder
  学校法人慶應義塾
- Industrial Property Rights Type
  特許
- Filing Date
  2015-06-11
- Data Source
  KAKENHI-PROJECT-25289298
[Presentation] CAPZA1過剰発現細胞を標的とした強制的オートファジー誘導タンパク質の開発2020
- Author(s)
  坂田陸郎，津川仁，鈴木秀和，藤原慶，土居信英
- Organizer
  第43回日本分子生物学会年会（オンライン開催）
- Data Source
  KAKENHI-PROJECT-20H04535
[Presentation] 膜透過性ペプチドを用いたCas9タンパク質-gRNA複合体の直接的な細胞内送達2020
- Author(s)
  古屋智規，藤原慶，土居信英
- Organizer
  第43回日本分子生物学会年会（オンライン開催）
- Data Source
  KAKENHI-PROJECT-20H04535
[Presentation] 細胞選択的なタンパク質デリバリーのためのヒト・シンシチン1由来膜透過促進ペプチドの最適化2020
- Author(s)
  前村帆南，藤原慶，土居信英
- Organizer
  第43回日本分子生物学会年会（オンライン開催）
- Data Source
  KAKENHI-PROJECT-20H04535
[Presentation] LDL受容体を標的とする細胞選択的なタンパク質のデリバリーのためのヒト由来膜透過促進ペプチドの最適化2019
- Author(s)
  前村帆南，岩城洸汰，藤原慶，土居信英
- Organizer
  第35回日本DDS学会学術集会
- Data Source
  KAKENHI-PROJECT-17H02103
[Presentation] ヒト・シンシチン１由来膜透過促進ペプチドのアラニンスキャニング変異解析2019
- Author(s)
  鈴木麻友子，岩城洸汰，須藤慧，藤原慶，土居信英
- Organizer
  第35回日本DDS学会学術集会
- Data Source
  KAKENHI-PROJECT-17H02103
[Presentation] ヒト由来膜透過促進ペプチドS19を利用したsiRNAデリバリー2019
- Author(s)
  中村桃子，藤原慶，土居信英
- Organizer
  第35回日本DDS学会学術集会
- Data Source
  KAKENHI-PROJECT-17H02103
[Presentation] ヒト由来膜透過促進ペプチドを利用したDDSの可能性2019
- Author(s)
  土居信英
- Organizer
  第21回ヒューマンサイエンス総合研究ワークショップ
- Invited
- Data Source
  KAKENHI-PROJECT-17H02103
[Presentation] ペプチド医薬の細胞質送達に向けたヒト由来膜透過促進ペプチドの応用2019
- Author(s)
  菊地萌希，岩城洸汰，藤原慶，土居信英
- Organizer
  第35回日本DDS学会学術集会
- Data Source
  KAKENHI-PROJECT-17H02103
[Presentation] Application of a human-derived fusogenic peptide to intracellular delivery of therapeutic peptides.2019
- Author(s)
  Kikuchi, M., Iwaki, K., Fujiwara, K., Doi, N.
- Organizer
  The Cold Spring Harbor Asia conference on Chemical Biology and Drug Discovery
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H02103
[Presentation] STALL-seq: selection of translational arrest sequences from a large E. coli genome-fragment library2018
- Author(s)
  Hamano, T., Nagumo, Y., Chadani, Y., Tokunaga, M., Fujiwara, K., Taguchi, H., Doi, N.
- Organizer
  International Symposium on "Proteins; from the Cradle to the Grave"
- Int'l Joint Research
- Data Source
  KAKENHI-PUBLICLY-17H05674
[Presentation] In vitro selection of eukaryotic translational arrest sequences from a random-sequence library using mRNA display2018
- Author(s)
  Umehara, T., Hamano, T., Chadani, Y., Fujiwara, K., Taguchi, H., Doi, N.
- Organizer
  International Symposium on "Proteins; from the Cradle to the Grave"
- Int'l Joint Research
- Data Source
  KAKENHI-PUBLICLY-17H05674
[Presentation] ヒト由来膜融合ペプチドと積み荷タンパク質の連結様式がその細胞質送達活性に与える影響2018
- Author(s)
  岩城洸汰，菊地萌希，須藤慧，藤原慶，土居信英
- Organizer
  第41回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-17H02103
[Presentation] タンパク質の細胞質送達を促進するヒト由来ペプチドの発見とDDSへの応用2018
- Author(s)
  土居信英
- Organizer
  LIP横浜オープンイノベーションカンファレンスIII
- Invited
- Data Source
  KAKENHI-PROJECT-17H02103
[Presentation] 真核生物由来の翻訳停止配列を試験管内で大規模に探索する手法の開発2018
- Author(s)
  梅原智文，濱野理，茶谷悠平，藤原慶，田口英樹，土居信英
- Organizer
  第41回日本分子生物学会年会
- Data Source
  KAKENHI-PUBLICLY-17H05674
[Presentation] STALL-seq法による大腸菌新規翻訳アレスト遺伝子の大規模探索と機能解析2018
- Author(s)
  濱野理，南雲優，茶谷悠平，徳永真由子，藤原慶，田口英樹，土居信英
- Organizer
  第41回日本分子生物学会年会
- Data Source
  KAKENHI-PUBLICLY-17H05674
[Presentation] ヒト由来膜透過促進ペプチドによるバイオ医薬の効率的な細胞質送達の可能性評価2018
- Author(s)
  菊地萌希，岩城洸汰，漆島穣一，須藤慧，藤原慶，土居信英
- Organizer
  第34回日本DDS学会学術集会
- Data Source
  KAKENHI-PROJECT-17H02103
[Presentation] ヒトSyncytin1由来膜融合ペプチドによるタンパク質の細胞質送達機構の解析2017
- Author(s)
  岩城洸汰，須藤慧，光山隼史，藤原慶，土居信英
- Organizer
  第33回日本DDS学会学術集会
- Data Source
  KAKENHI-PROJECT-17H02103
[Presentation] mRNAディスプレイ法によるヒト抗GPCR単一ドメイン抗体の試験管内選択2017
- Author(s)
  漆島穣一，海野佑樹，須藤慧，藤原慶，土居信英
- Organizer
  第33回日本DDS学会学術集会
- Data Source
  KAKENHI-PROJECT-17H02103
[Presentation] Large-scale identification of E. coli translational arrest sequences using mRNA display.2017
- Author(s)
  Hamano, T., Nagumo, Y., Chadani, Y., Tokunaga, M., Fujiwara, K., Taguchi, H., Doi, N.
- Organizer
  International Symposium on Protein Quality Control
- Int'l Joint Research
- Data Source
  KAKENHI-PUBLICLY-17H05674
[Presentation] In vitro selection of translational arrest sequences using mRNA display.2016
- Author(s)
  Hamano, T., Nagumo, Y., Chadani, Y., Tokunaga, M., Fujiwara, K., Taguchi, H., Chiba, S., Ito, K., Doi, N.
- Organizer
  Nascent Chain Biology Meeting
- Place of Presentation
  Fuji Lake Hotel (Yamanashi, Japan)
- Year and Date
  2016-09-01
- Int'l Joint Research
- Data Source
  KAKENHI-PUBLICLY-15H01543
[Presentation] ヒト由来膜融合促進ペプチドとpH依存性抗体を組み合わせた膜透過抗体の開発2016
- Author(s)
  須藤慧，新倉啓介，藤原慶，土居信英
- Organizer
  第39回日本分子生物学会年会
- Place of Presentation
  パシフィコ横浜（神奈川県・横浜市）
- Year and Date
  2016-11-30
- Data Source
  KAKENHI-PROJECT-15K12545
[Presentation] PURE mRNAディスプレイ法による低分子抗体の試験管内選択2015
- Author(s)
  海野佑樹，南雲優，藤原慶，堀澤健一，柳川弘志，角田慎一，向洋平，堤康央，土居信英
- Organizer
  第38回日本分子生物学会年会・第88回日本生化学会大会合同大会
- Place of Presentation
  神戸ポートアイランド（兵庫県・神戸市）
- Year and Date
  2015-12-01
- Data Source
  KAKENHI-PROJECT-25289298
[Presentation] ヒト由来膜融合促進ペプチドによる生体高分子の細胞内送達2015
- Author(s)
  須藤慧，新倉啓介，藤原慶，土居信英
- Organizer
  第31回日本DDS学会学術集会
- Place of Presentation
  京王プラザホテル（東京都・新宿区）
- Year and Date
  2015-07-02
- Data Source
  KAKENHI-PROJECT-25289298
[Presentation] ヒト由来膜融合促進ペプチドによる生体高分子の細胞内送達2015
- Author(s)
  須藤慧，新倉啓介，藤原慶，土居信英
- Organizer
  第31回日本DDS学会学術集会
- Place of Presentation
  京王プラザホテル（東京都・新宿区）
- Year and Date
  2015-07-02
- Data Source
  KAKENHI-PROJECT-15K12545
[Presentation] PURE mRNAディスプレイ法による低分子抗体の試験管内選択2015
- Author(s)
  海野佑樹，南雲優，藤原慶，堀澤健一，柳川弘志，角田慎一，向洋平，堤康央，土居信英
- Organizer
  第38回日本分子生物学会年会・第88回日本生化学会大会合同大会
- Place of Presentation
  神戸ポートアイランド（兵庫県・神戸市）
- Year and Date
  2015-12-01
- Data Source
  KAKENHI-PUBLICLY-15H01543
[Presentation] 共有結合型DNAディスプレイ法による二重特異性抗体の試験管内進化2015
- Author(s)
  中山真尚，小宮尚子，藤原慶，堀澤健一，土居信英
- Organizer
  第38回日本分子生物学会年会・第88回日本生化学会大会合同大会
- Place of Presentation
  神戸ポートアイランド（兵庫県・神戸市）
- Year and Date
  2015-12-03
- Data Source
  KAKENHI-PROJECT-25289298
[Presentation] Bindin由来膜融合促進ペプチドを用いた膜透過抗体および膜透過促進抗体の構築2014
- Author(s)
  新倉啓介，堀澤健一，土居信英
- Organizer
  第30回日本DDS学会学術集会
- Place of Presentation
  東京
- Year and Date
  2014-07-30
- Data Source
  KAKENHI-PROJECT-25289298
[Presentation] PURE mRNAディスプレイ法を用いた翻訳停止ペプチド配列の試験管内選択2014
- Author(s)
  南雲優，水原真実子，藤原慶，堀澤健一，柳川弘志，土居信英
- Organizer
  第37回日本分子生物学会年会
- Place of Presentation
  横浜
- Year and Date
  2014-11-27
- Data Source
  KAKENHI-PROJECT-25289298
[Presentation] 膜融合促進ペプチドB18およびB55による生体高分子の細胞内送達2014
- Author(s)
  新倉啓介，藤原慶，堀澤健一，土居信英
- Organizer
  第37回日本分子生物学会年会
- Place of Presentation
  横浜
- Year and Date
  2014-11-26
- Data Source
  KAKENHI-PROJECT-25289298
[Presentation] 共有結合型バイシストロン性DNAディスプレイ法による抗体Fab断片の試験管内進化2014
- Author(s)
  小宮尚子，住田壮，藤原慶，堀澤健一，柳川弘志，土居信英
- Organizer
  第37回日本分子生物学会年会
- Place of Presentation
  横浜
- Year and Date
  2014-11-25
- Data Source
  KAKENHI-PROJECT-25289298
[Presentation] ぺプチドおよび酵素の大腸菌表層ディスプレイに関する比較研究2013
- Author(s)
  高谷祐介,堀津健一,土居信英
- Organizer
  .第36回日本分子生物学会年会
- Place of Presentation
  神戸
- Year and Date
  2013-12-04
- Data Source
  KAKENHI-PROJECT-24656508
[Presentation] A novel chemical tool for proteomic analysis of translational control2013
- Author(s)
  Horisawa K., Miyazawa T., Ohkawa K., Oka K. and Doi N.
- Organizer
  The 12th Human Proteome Organisation World Congress
- Place of Presentation
  パシフィコ横浜（横浜市）
- Data Source
  KAKENHI-PROJECT-24500447
[Presentation] 酸化還元酵素のハイスループットなスクリーニング系の構築2013
- Author(s)
  及木遼,片山道信,加藤太亮,杉谷藍,渡辺剛志,栄長泰明,松本佳宣,堀津健一,土居信英
- Organizer
  第36回日本分子生物学会年会
- Place of Presentation
  神戸
- Year and Date
  2013-12-05
- Data Source
  KAKENHI-PROJECT-24656508
[Presentation] 神経発生におけるRNA結合タンパク質Msi1による翻訳制御2012
- Author(s)
  原裕恵、堀澤健一、松尾薫、柳川弘志、土居信英
- Organizer
  第35回日本分子生物学会年会
- Place of Presentation
  福岡
- Data Source
  KAKENHI-PROJECT-24500447
[Presentation] In vitro virus (IVV)法を用いた人工癌幹細胞の接着を阻害する一本鎖抗体の選択2012
- Author(s)
  田畠典子, 佐久間裕子, 清水孝恒, 佐谷秀行, 土居信英, 柳川弘志
- Organizer
  第35回日本分子生物学会年会
- Place of Presentation
  福岡
- Data Source
  KAKENHI-PROJECT-22360351
[Presentation] RNA-binding protein Msi1 regulates the expression of an axon guidance receptor through translational repression2012
- Author(s)
  Hara H., Horisawa K., Yanagawa H., Doi N.
- Organizer
  Translational Control
- Place of Presentation
  NewYork
- Data Source
  KAKENHI-PROJECT-24500447
[Presentation] CD44とxCTの相互作用を阻害する抗CD44v一本鎖抗体の試験管内選択2011
- Author(s)
  梅澤洋貴,田畠典子,佐久間裕子,竹中悠馬,松本佳宣,土居信英,永野修 ,佐谷秀行 ,柳川弘志
- Organizer
  第34回日本分子生物学会年会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-22360351
[Presentation] Translationally-regulated proteomics using biotinylated puromycin2011
- Author(s)
  大川皓司, 堀澤健一, 柳川弘志, 土居信英
- Organizer
  第34回日本分子生物学会年会
- Place of Presentation
  横浜
- Year and Date
  2011-12-13
- Data Source
  KAKENHI-PROJECT-22658111
[Presentation] 高親和性抗CCR5一本鎖抗体の中立的浮動による試験管内進化2011
- Author(s)
  佐藤亮太,土居信英,三隅将吾,庄司省三,松島綱治,横地祥司,柳川弘志
- Organizer
  第34回日本分子生物学会年会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-22360351
[Presentation] オンチップ共発現マイクロアレイによる転写制御ネットワーク解析2010
- Author(s)
  早坂俊二, 井上鈴代, 堀澤健一, 柳川弘志, 土居信英
- Organizer
  第33回日本分子生物学会年会
- Place of Presentation
  神戸
- Year and Date
  2010-12-08
- Data Source
  KAKENHI-PROJECT-22658111
[Presentation] HIV の侵入を阻害する抗 CCR5 一本鎖抗体の試験管内進化2010
- Author(s)
  佐藤亮太,土居信英,三隅将吾,松島綱治,横地祥司,柳川弘志
- Organizer
  第33回日本分子生物学会年会
- Place of Presentation
  神戸
- Data Source
  KAKENHI-PROJECT-22360351
[Presentation] In vitro display methods for heterodimeric proteins using in vitro compartmentaliza-tion2010
- Author(s)
  Sumida, T., Yanagawa, H., Doi, N
- Organizer
  Pacifichem 2010
- Place of Presentation
  Honolulu
- Data Source
  KAKENHI-PROJECT-22360351
[Presentation] In vitro selection of functional SH3 domains with reduced amino-acid alphabets2010
- Author(s)
  Tanaka, J., Yanagawa, H., Doi, N.
- Organizer
  Pacifichem 2010
- Place of Presentation
  Honolulu
- Data Source
  KAKENHI-PROJECT-22360351
[Presentation] DNAディスプレイ法によるFab抗体の完全試験管内選択2008
- Author(s)
  住田壮, 土居信英, 柳川弘志
- Organizer
  第81回日本生化学会・第31回日本分子生物学会合同年会
- Place of Presentation
  神戸
- Year and Date
  2008-12-09
- Data Source
  KAKENHI-PROJECT-19360377
[Presentation] ビーズエマルジョンPCRとSTABLE法の組み合わせによる受容体ペプチドリガンド探索手法の開発2008
- Author(s)
  丸岡優子, 住田壮, 山川奈津子, 土居信英, 柳川弘志
- Organizer
  第81回日本生化学会・第31回日本分子生物学会合同年会
- Place of Presentation
  神戸
- Year and Date
  2008-12-12
- Data Source
  KAKENHI-PROJECT-19360377
[Presentation] IVV法による選択実験の多用途性2008
- Author(s)
  田畠典子, 佐久間裕子, 山川奈津子, 土居信英, 柳川弘志
- Organizer
  第81回日本生化学会・第31回日本分子生物学会合同年会
- Place of Presentation
  神戸
- Year and Date
  2008-12-09
- Data Source
  KAKENHI-PROJECT-19360377
[Presentation] 抗体医薬開発に向けたヒト一本鎖抗体のIVVスクリーニング2008
- Author(s)
  木村香緒梨, 小磯崇, 田畠典子, 土居信英, 柳川弘志
- Organizer
  第81回日本生化学会・第31回日本分子生物学会合同年会
- Place of Presentation
  神戸
- Year and Date
  2008-12-09
- Data Source
  KAKENHI-PROJECT-19360377
[Presentation] In vitro virus法を用いたヒト一本鎖抗体の試験管内選択2007
- Author(s)
  小磯崇, 福田伊佐央, 鬼丸美智子, 田畠典子, 土居信英, 高嶋秀昭, 柳川弘志
- Organizer
  第80回日本生化学会・第30回日本分子生物学会合同年会
- Place of Presentation
  横浜
- Year and Date
  2007-12-11
- Data Source
  KAKENHI-PROJECT-19360377

1. YANAGAWA Hiroshi (40327672)

# of Collaborated Projects: 8 results

# of Collaborated Products: 31 results
2. MATSUSHIMA Koji (50222427)

# of Collaborated Projects: 2 results

# of Collaborated Products: 2 results
3. HORISAWA Kenichi (70424207)

# of Collaborated Projects: 2 results

# of Collaborated Products: 9 results
4. SUZUKI HIDEKAZU (70255454)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
5. 津川仁 (30468483)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
6. 藤原慶 (20580989)

# of Collaborated Projects: 2 results

# of Collaborated Products: 21 results
7. MISUMI Shogo (40264311)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
8. EINAGA Yasuaki (00322066)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
9. MATSUMOTO Yoshinori (60252318)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
10. WASHIO Takanori (50338266)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. MORI Hirotada (90182203)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
12. 今井貴雄 (10383712)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
13. 芝田晋介 (70407089)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
14. 岡野栄之 (60160694)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
15. 本多政夫 (00272980)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
16. 堀本勝久 (40238803)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
17. 岡田光 (50788916)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
18. 佐藤智典 (00162454)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
19. OYOBIKI Ryo

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
20. SHITARA Shunya

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
21. SHIMOKIHARA Shota

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
22. NIIKURA Keisuke

# of Collaborated Projects: 1 results

# of Collaborated Products: 5 results
23. SUDO Kei

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
24. IWAKI Kouta

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
25. SAYA Hideyuki

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
26. NAGATA Takashi

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
27. NAKAYAMA Takahiro

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
28. 高橋栄夫

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
29. 柳澤実穂

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
30. 義永那津人

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
31. 野村慎一郎

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

DOI Nobuhide 土居 信英

Research Projects

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肝微小環境の構造理解に基づく新たな代謝性肝疾患治療の確立

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Development of a two-step molecular targeted therapy to eliminate gastric cancer stem cells and progenitor cells

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細胞内の創薬ターゲットに対するがん細胞選択的な膜透過抗体医薬の開発Principal Investigator

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mRNAディスプレイ法による翻訳アレスト配列の大規模探索Principal Investigator

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Development of cell-specific DDS for biopharmaceuticals using a novel human-derived membrane penetration-enhancing peptidePrincipal Investigator

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Mandatory autophagy induction targeting gastric cancer stem cells by hybrid small molecule antibodies

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Fusogenic peptides combined with pH-dependent antibody fragments for cell-specific intracellular drug deliveryPrincipal Investigator

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mRNAディスプレイ法による翻訳アレスト配列探索技術の開発Principal Investigator

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Cell-free display technologies for development of next-generation therapeutic antibody fragmentsPrincipal Investigator

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Analysis for a neural differentiation regulatory factor, Musashi1

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Development of an efficient screening technique for oxidoreductases used for biofuel cellsPrincipal Investigator

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Cell-free display technology for optimization of antibody drugsPrincipal Investigator

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On-Chip Co-expression Microarrays for Precise Analysis of Transcriptional Regulatory NetworksPrincipal Investigator

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DOI Nobuhide 土居信英

[Book] 進化分子工学　～高速分子進化によるタンパク質・核酸の開発～2013

[Book] 進化分子工学　～高速分子進化によるタンパク質・核酸の開発～2013