OOKAWARA Tomomi 大河原知水

Researcher Number	50330452
Other IDs
Affiliation *help	2016 – 2018 : 兵庫医療大学, 薬学部, 教授 2016 – 2018 : 兵庫医科大学, 医学部, その他 2011 – 2012 : 兵庫医療大学, 薬学部, 教授 2008 – 2010 : Hyogo University of Health Sciences, 薬学部, 准教授 2001 – 2007 : 兵庫医科大学, 医学部, 講師
Review Section/Research Field	Principal Investigator Hygiene / Hygiene Except Principal Investigator Pathological medical chemistry / Nerve anatomy/Neuropathology / General medical chemistry / Pathological medical chemistry
Keywords	Principal Investigator スーパーオキシドジスムターゼ / 酸化ストレス / 動脈硬化 / 活性酸素 / 3T3-LI cell / 生活習慣病 / 3T3-L1 / 細胞外型SOD / extracellular superoxide dismutase / 血管平滑筋 … More Except Principal Investigator Cu / スーパーオキシドジスムターゼ / HB-EGF / Zn-SOD / 筋萎縮性側索硬化症 / 酸化ストレス / 動脈硬化 / 活性酸素 / 抗体 / reactive oxygen species / 酸化 / ALS / 家族性筋萎縮性側策硬化症 / superoxside dismutase / プロテオグリカン / arterioselerosis / FALS / amyotrophic lateral sclerosis / スーパーオキドジスムターゼ / 細胞外型SOD / SOD1ノックアウトマウス / monoclonal antibody / モノクローナル抗体 / 糖鎖 / 酸化的翻訳後修飾 / 銅代謝 / HP-EGF / Cys111 / 一酸化窒素 / conformational change / arteriosclerosis / cleavage of oligosaccharides / SOD / EC-SOD / アポトーシス / トランスフェリン / 血管平滑筋 / LEC rat / Cu,Zn-SOD / Cu/Zn-SODノックアウトマウス / 突然変異 / 筋萎縮性側索硬化症(ALS) / 腎臓 / Zn-SODノックアウトマウス / 活性酸素種 / ヒドロキシノネナール / superoxide dismutase / 鉄 / LECラット / SOD1 / oxidation / 過酸化脂質 / smooth muscle cells / 構造変化 / N型糖鎖 / 過酸化物 / DNA傷害 / sugar chain / 核移行シグナル / Cu, Zn-SOD / チャージアイソマー / Nitric oxide / ヒアルロン酸 / ROS / グルタチオンSトランスフェラーゼ / MALDI-TOF-MS / oxidative stress / グリコサミノグリカン / JNK / 脳神経疾患 / 銅イオン Less

Obesity and oxidative stress: involvement of SOD in the physiology of metabolic syndrome and atherosclerosisPrincipal Investigator
- Principal Investigator
  
  OOKAWARA Tomomi
- Project Period (FY)
  2010 – 2012
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Hygiene
- Research Institution
  Hyogo University of Health Sciences
The compensatory mechanism against oxidative stress in kidney dysfunction
- Principal Investigator
  
  SUZUKI Keiichiro
- Project Period (FY)
  2008 – 2010
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Pathological medical chemistry
- Research Institution
  Hyogo College of Medicine
The role of oxidized SOD1 on ALS using the new antibody against oxidized SOD1 (anti-C111ox-SOD1)
- Principal Investigator
  
  FUJIWARA Noriko
- Project Period (FY)
  2007 – 2009
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Nerve anatomy/Neuropathology
- Research Institution
  Hyogo College of Medicine
Anti-oxidative effect of EC-SOD and prevention of atherosclerosis in lifestyle-related diseases.Principal Investigator
- Principal Investigator
  
  OOKAWARA Tomomi
- Project Period (FY)
  2007 – 2008
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Hygiene
- Research Institution
  Hyogo University of Health Sciences
  Hyogo College of Medicine
Nuclear translocation of antioxidant enzymes and ROS metabolism
- Principal Investigator
  
  SUZUKI Keiichiro
- Project Period (FY)
  2006 – 2007
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Pathological medical chemistry
- Research Institution
  Hyogo College of Medicine
Conformational change in FALS-linked mutant Cu/Zn-SOD analyzed by monoclonal antibodies
- Principal Investigator
  
  FUJIWARA Noriko
- Project Period (FY)
  2005 – 2006
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Nerve anatomy/Neuropathology
- Research Institution
  Hyogo College of Medicine
Nuclear translocation of antioxidant enzymes and ROS metabolism
- Principal Investigator
  
  SUZUKI Keiichirou
- Project Period (FY)
  2003 – 2005
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  General medical chemistry
- Research Institution
  Hyogo College of Medicine
A possible mechanism of mutagenesis : oxidative stress and nuclear translocation of superoxide dismutase.Principal Investigator
- Principal Investigator
  
  OOKAWARA Tomomi
- Project Period (FY)
  2002 – 2003
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Hygiene
- Research Institution
  Hyogo College of Medicine
Mechanism of arteriosclerosis evoked by production and processing of HB-EGF induced by nitric oxide
- Principal Investigator
  
  SUZUKI Keiichiro
- Project Period (FY)
  2001 – 2002
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Pathological medical chemistry
- Research Institution
  Hyogo College of Medicine

All 2011 2009 2008 2007 2004 2003 Other

All Journal Article Presentation Book

[Book] 生体の抗酸化システム(1)スーパーオキシドジスムターゼ系. 酸化ストレスの医学, (吉川敏一監修)2008
- Author(s)
  鈴木敬一郎, 藤原範子, 大河原知水
- Publisher
  診断と治療社
- Data Source
  KAKENHI-PROJECT-19590605
[Book] ストレスの医学(吉川敏一監修)(CHAPTER 3, 生体の抗酸化システム(1)スーパーオキシドジスムターゼ系酸化)2008
- Author(s)
  鈴木敬一郎、藤原範子、大河原知水
- Publisher
  診断と治療社
- Data Source
  KAKENHI-PROJECT-20590320
[Book] CHAPTER 3, 生体の抗酸化システム(1)スーパーオキシドジスムターゼ系、酸化ストレスの医学(吉川敏一監修)
- Author(s)
  鈴木敬一郎、藤原範子、大河原知水
- Publisher
  診断と治療社
- Data Source
  KAKENHI-PROJECT-19500313
[Journal Article] N-Glycosylation profiling of recombinant mouse extracellular superoxide dismutase produced in Chinese hamster ovary cells.2011
- Author(s)
  Korekane H
- Journal Title
  
  Glycoconjugate Journal
  
  Volume : 28 Pages : 183-196
- DOI
  10.1007/s10719-011-9333-6
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-20117008, KAKENHI-PROJECT-22590563, KAKENHI-PROJECT-22650101, KAKENHI-PROJECT-23501303
[Journal Article] Voluntary exercise attenuates obesity-associated inflammation through ghrelin expressed in macrophages.2011
- Author(s)
  Kizaki, T., Maegawa, T., Sakurai, T., Ogasawara, J., Ookawara, T., Oh-ishi, S., Izawa, T., Haga, S. & Ohno, H.
- Journal Title
  
  Biochem Biophys Res Commun.
  
  Volume : 413 Pages : 454-459
- DOI
  10.1016/j.bbrc.2011.08.117
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21300237, KAKENHI-PROJECT-22590563, KAKENHI-PROJECT-22650154, KAKENHI-PROJECT-22700655, KAKENHI-PROJECT-23590752, KAKENHI-PROJECT-23700778
[Journal Article] 酸化ストレスと健康2009
- Author(s)
  江口裕伸、藤原範子、大河原知水、鈴木敬一郎、谷口直之
- Journal Title
  
  生物資料分析 Vol.32,No.4
  
  Pages : 247-256
- Data Source
  KAKENHI-PROJECT-19500313
[Journal Article] 酸化ストレスと健康、2009
- Author(s)
  江口裕伸、藤原範子、大河原知水、鈴木敬一郎、谷口直之
- Journal Title
  
  生物資料分析 Vol.32, No.4
  
  Pages : 247-256
- Data Source
  KAKENHI-PROJECT-20590320
[Journal Article] Protective role of glutathione S-transferase A4 induced in copper/zinc-superoxide dismutase knockout mice2009
- Author(s)
  Yoshihara D., Fujiwara N., Ookawara T., Kato S., Sakiyama H., Yokoe S., Eguchi H., Suzuki K.
- Journal Title
  
  Free Radic. Biol. Med. 47
  
  Pages : 559-567
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590320
[Journal Article] Protective role of glutathione S-transferase A4 induced in copper/zinc-superoxide dismutase knockout mice2009
- Author(s)
  Yoshihara D., Fujiwara N., Ookawara T., Kato S., Sakiyama H., Yokoe S., Eguchi H., Suzuki K
- Journal Title
  
  Free Radic. Biol. Med 47
  
  Pages : 559-567
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19500313
[Journal Article] Acute exercise increases expression of extracellular superoxide dismutase in skeletal muscle and the aorta.2008
- Author(s)
  Hitomi Y, Watanabe S, Kizaki T, Sakurai T, Takemasa T, Haga S, Ookawara T, Suzuki K, Ohno H.
- Journal Title
  
  Redox Rep. 13
  
  Pages : 213-6
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590605
[Journal Article] 新時代の糖尿病学(2)病因・診断・治療研究の進歩スーパーオキシドジスムターゼ2008
- Author(s)
  大野秀樹, 木崎節子, 櫻井拓也, 大河原知水, 鈴木敬一郎
- Journal Title
  
  日本臨牀 66(増刊4)
  
  Pages : 351-354
- Data Source
  KAKENHI-PROJECT-19590605
[Journal Article] Oxidative modification to cysteine sulfonic Acid of cys111 in human copper-zinc superoxide dismutase2007
- Author(s)
  Fujiwara N., Nakano M, Kato S, Yoshihara D, Ookawara T, Eguchi H, Taniguchi N, Suzuki K
- Journal Title
  
  J. Biol. Chem 282
  
  Pages : 35933-35944
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19500313
[Journal Article] Oxidative modification to cysteine sulfonic acid of Cys111 in human copper-zinc superoxide dismutase.2007
- Author(s)
  Yoshihara D, Ookawara T, Eguchi H, Taniguchi N, Suzuki K.
- Journal Title
  
  J. Biol Chem. 282
  
  Pages : 35933-44
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590605
[Journal Article] Down-regulation of beta2-adrenergic receptor expression by exercise training increase IL-12 production by macrophages following LPS stimulation.2004
- Author(s)
  Ookawara, T.
- Journal Title
  
  Biochem.Biophys.Res.Commun. 322
  
  Pages : 379-384
- Data Source
  KAKENHI-PROJECT-15590258
[Journal Article] Effects of endurance training on three Superoxide dismutase isoenzymes in human plasma.2003
- Author(s)
  Ookawara, T.
- Journal Title
  
  Free Radic. Res. 372
  
  Pages : 713-719
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15590258
[Journal Article] An inter-subunit disulfide bond affects affinity of human lung extracellular superoxide dismutase to heparin.2003
- Author(s)
  Ookawara, T.
- Journal Title
  
  Free Radic. Res. 37
  
  Pages : 823-827
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15590258
[Journal Article] Effects of oxidative stress on the nuclear translocation of extracellular superoxide dismutase.2003
- Author(s)
  Ookawara, T.
- Journal Title
  
  Biochem. Biophys. Res. Commun. 303
  
  Pages : 914-919
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15590258
[Journal Article] Extracellular superoxide dismutase following cerebral ischemia in mice.2003
- Author(s)
  Ookawara, T.
- Journal Title
  
  Acta Neurochir Suppl. 86
  
  Pages : 83-85
- Data Source
  KAKENHI-PROJECT-15590258
[Journal Article] Effects of endurance training on three Superoxide dismutase isoenzymes in human plasma.2003
- Author(s)
  Ookawara, T.
- Journal Title
  
  Free Radic.Res. 372
  
  Pages : 713-719
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15590258
[Journal Article] Effects of oxidative stress on the nuclear translocation of extracellular superoxide dismutase.2003
- Author(s)
  Ookawara, T.
- Journal Title
  
  Biochem.Biophys.Res.Commun. 303
  
  Pages : 914-919
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15590258
[Journal Article] An inter-subunit disulfide bond affects affinity of human lung extracellular superoxide dismutase to heparin.2003
- Author(s)
  Ookawara, T.
- Journal Title
  
  Free Radic.Res. 37
  
  Pages : 823-827
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15590258
[Presentation] ヒトCu/Zn-スーパーオキシドジスムターゼ(SOD1)のCys111の酸化と酸化型SOD1特異抗体の作製2008
- Author(s)
  藤原範子、中の三弥子、大河原知水、吉原大作、横江俊一、加藤信介、谷口直之、鈴木敬一郎
- Organizer
  第61回日本酸化ストレス学会学術集会
- Place of Presentation
  京都
- Data Source
  KAKENHI-PROJECT-19500313
[Presentation] Cys111 in human copper-zinc-superoxide dismutase is a primary target for peroxidation to cysteine sulfonic acid2008
- Author(s)
  Fujiwara N., Nakano M., Yoshihara D., Ookawara T., Eguchi H., Taniguchi N., Suzuki K
- Organizer
  The Gordon Research conference on Thiol-based Redox Regulation and Signaling
- Place of Presentation
  Lucca, Italy
- Data Source
  KAKENHI-PROJECT-19500313
[Presentation] ヒトCu/Zn-スーパーオキシドジスムターゼ(SOD1)のCys111の酸化と酸化型SOD1特異抗体の作製2008
- Author(s)
  藤原範子、中の三弥子、大河原知水、吉原大作、横江俊一、加藤信介、谷口直之、鈴木敬一郎
- Organizer
  第61回日本酸化ストレス学会学術集会(p66)
- Place of Presentation
  京都(抄録)
- Data Source
  KAKENHI-PROJECT-20590320
[Presentation] SOD1ノックアウトマウスにおけるGSTA4の誘導と生理的意義2008
- Author(s)
  吉原大作、藤原範子、大河原知水、崎山晴彦、横江俊一、江口裕伸、鈴木敬一郎
- Organizer
  第31回日本分子生物学会年会・第81回日本生化学会大会合同大会(BMB2008)(p14)
- Place of Presentation
  神戸(Late-Breaking Abstracts)
- Data Source
  KAKENHI-PROJECT-20590320
[Presentation] Cu/Zn-SODノックアウトマウスにおけるGSTA4の生理的意義2008
- Author(s)
  吉原大作、藤原範子、大河原知水、横江俊一、崎山晴彦、鈴木敬一郎
- Organizer
  第61回日本酸化ストレス学会学術集会
- Place of Presentation
  京都
- Data Source
  KAKENHI-PROJECT-20590320
[Presentation] EC-SODの細胞内分布に対する酸化ストレス、一酸化窒素の影響2008
- Author(s)
  大河原知水, ほか
- Organizer
  第8回日本NO学会学術集会
- Place of Presentation
  仙台市国際センター
- Year and Date
  2008-05-10
- Data Source
  KAKENHI-PROJECT-19590605
[Presentation] GSTA4-4 as a biomarker of oxidative stress in renal tubular cells2008
- Author(s)
  Yoshihara D., Fujiwara N., Ookawara T., Yokoe S., Suzuki K.
- Organizer
  BOSHD2008 Biomarkers of Oxidative Stress in Health and Diseases
- Place of Presentation
  Osaka
- Data Source
  KAKENHI-PROJECT-20590320
[Presentation] Cys111 in human copper-zinc-superoxide dismutase is a primary target for peroxidation to cysteine sulfonic acid2008
- Author(s)
  Fujiwara N., Nakano M., Yoshihara D., Ookawara T., Eguchi H., Taniguchi N., Suzuki K.
- Organizer
  The Gordon Research conference on Thiol-based Redox Regulation and Signaling
- Place of Presentation
  Lucca, Italy
- Data Source
  KAKENHI-PROJECT-20590320
[Presentation] EC-SODの細胞内分布に対する酸化ストレス、一酸化窒素の影響2008
- Author(s)
  大河原知水
- Organizer
  第8回日本NO学会学術集会
- Place of Presentation
  仙台市
- Year and Date
  2008-05-10
- Data Source
  KAKENHI-PROJECT-19590605
[Presentation] Role of Cys111 in an oxidative damage and generation of charge isomers of human Cu/Zn-superoxide dismutase2007
- Author(s)
  hihara, D., Ookawara, T., Taniguchi, N., Suzuki, K
- Organizer
  第30回日本分子生物学会大会、第80回日本生化学会大会、合同大会(BMB2007)
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-19500313
[Presentation] Effects of copper metabolism on behavioral functions and brain monoamine contents in Wistar and Wilson's disease model rats2007
- Author(s)
  Fujiwara, N., Iso, H., Kitanaka, N., Kitanaka, J., Yoshihara, D., Ookawara, T., Suzuki, K
- Organizer
  ISTERH2007
- Place of Presentation
  Crete, Greece
- Data Source
  KAKENHI-PROJECT-19500313
[Presentation] Role of Cys111 in an oxidative damage of human Cu/Zn-superoxide dismutase2007
- Author(s)
  Fujiwara, N., Nakano, M., Yoshihara, D., Ookawara, T., Eguchi, H., Taniguchi, N., Suzuki, K
- Organizer
  第30回日本神経科学大会、第50回日本神経化学会大会、第17回日本神経回路学会大会、合同大会(Neuro 2007)
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-19500313
[Presentation] マウスEC-SODの翻訳調節機構2007
- Author(s)
  大河原知水, ほか
- Organizer
  第80回日本生化学会大会
- Place of Presentation
  横浜市
- Year and Date
  2007-12-14
- Data Source
  KAKENHI-PROJECT-19590605

1. SUZUKI Keiichiro (70221322)

# of Collaborated Projects : 10results

# of Collaborated Products : 22results
2. FUJIWARA Noriko (10368532)

# of Collaborated Projects : 8results

# of Collaborated Products : 17results
3. EGUCHI Hironobu (60351798)

# of Collaborated Projects : 6results

# of Collaborated Products : 9results
4. YOKOE Syunichi (40454756)

# of Collaborated Projects : 3results

# of Collaborated Products : 7results
5. SAKIYAMA Haruhiko (30508958)

# of Collaborated Projects : 2results

# of Collaborated Products : 4results
6. KOREKANE Atsuko (80461169)

# of Collaborated Projects : 2results

# of Collaborated Products : 1results
7. YOSHIHARA Daisaku (00567266)

# of Collaborated Projects : 1results

# of Collaborated Products : 6results
8. YAMAGUCHI Yukihiro (60330453)

# of Collaborated Projects : 1results

# of Collaborated Products : 0results
9. KUROTSU Tositsugu (20098528)

# of Collaborated Projects : 1results

# of Collaborated Products : 0results
10. MATSUMOTO Takeo

# of Collaborated Projects : 0results

# of Collaborated Products : 1results
11. MIYAMOTO Yasuhide

# of Collaborated Projects : 0results

# of Collaborated Products : 1results
12. KIZAKI Takako

# of Collaborated Projects : 0results

# of Collaborated Products : 1results
13. OHNO Hideki

# of Collaborated Projects : 0results

# of Collaborated Products : 1results
14. SAKURAI Takuya

# of Collaborated Projects : 0results

# of Collaborated Products : 1results
15. OGASAWARA Jyunetsu

# of Collaborated Projects : 0results

# of Collaborated Products : 1results
16. 松本明郎

# of Collaborated Projects : 0results

# of Collaborated Products : 1results

OOKAWARA Tomomi 大河原 知水

Research Projects

Research Products

Co-Researchers

Obesity and oxidative stress: involvement of SOD in the physiology of metabolic syndrome and atherosclerosisPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

The compensatory mechanism against oxidative stress in kidney dysfunction

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

The role of oxidized SOD1 on ALS using the new antibody against oxidized SOD1 (anti-C111ox-SOD1)

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Anti-oxidative effect of EC-SOD and prevention of atherosclerosis in lifestyle-related diseases.Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Nuclear translocation of antioxidant enzymes and ROS metabolism

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Conformational change in FALS-linked mutant Cu/Zn-SOD analyzed by monoclonal antibodies

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Nuclear translocation of antioxidant enzymes and ROS metabolism

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

A possible mechanism of mutagenesis : oxidative stress and nuclear translocation of superoxide dismutase.Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Mechanism of arteriosclerosis evoked by production and processing of HB-EGF induced by nitric oxide

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Book] 生体の抗酸化システム(1)スーパーオキシドジスムターゼ系. 酸化ストレスの医学, (吉川敏一 監修)2008

Author(s)

Publisher

Data Source

[Book] ストレスの医学(吉川敏一監修)(CHAPTER 3, 生体の抗酸化システム(1)スーパーオキシドジスムターゼ系酸化)2008

Author(s)

Publisher

Data Source

[Book] CHAPTER 3, 生体の抗酸化システム(1)スーパーオキシドジスムターゼ系、酸化ストレスの医学(吉川敏一監修)

Author(s)

Publisher

Data Source

[Journal Article] N-Glycosylation profiling of recombinant mouse extracellular superoxide dismutase produced in Chinese hamster ovary cells.2011

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Voluntary exercise attenuates obesity-associated inflammation through ghrelin expressed in macrophages.2011

Author(s)

Journal Title

DOI

Data Source

OOKAWARA Tomomi 大河原知水

[Book] 生体の抗酸化システム(1)スーパーオキシドジスムターゼ系. 酸化ストレスの医学, (吉川敏一監修)2008

[Journal Article] 新時代の糖尿病学(2)病因・診断・治療研究の進歩スーパーオキシドジスムターゼ2008