NISHII Kazuhiro 西井一浩

Researcher Number	50332713
Affiliation (based on the past Project Information) *help	2005 – 2006: 三重大学, 医学部附属病院, 助手 2002 – 2004: 三重大学, 医学部, 助手 2002: Mie University, Faculty of Medicine, Research Associate, 医学部附属病院, 助手 2001: 三重大学, 医学部・附属病院, 助手
Review Section/Research Field	Principal Investigator Hematology / Hematology
Keywords	Principal Investigator tyrosine kinase / mutation / acute myeloid leukemia / c-kit / t(8;21) / Ikaros / 遺伝子異常 / 急性骨髄性白血病 / 予後因子 / KIT … More / 急性白血病 / 転写因子 / 急性リンパ性白血病 / 成人 / 小児 / 分子生物学 / 発がん機構 / 白血病 / 発癌機構 / リンパ性白血病 / 分子生分学 / acute leukemia / transcription factor / acute lymphoblastic leukemia / adult / childhood / molecular biology / cancer / 染色体異常 / 難治性白血病 / inhibitor / prognostic factor / abnormal chromosome / tyrosien kinase / t(8;21)AML / inv(16) AML / 骨髄異形性症候群 / point mutation / t(8;21) AML / inv(16) Less

Research Projects
(3 results)
Research Products
(42 results)

Characteristics of the leukemia with KIT mutationPrincipal Investigator
- Principal Investigator
  
  NISHII Kazuhiro
- Project Period (FY)
  2005 – 2006
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Hematology
- Research Institution
  Mie University
Active mutation of c-kit gene in acute myeloid leukemiaPrincipal Investigator
- Principal Investigator
  
  NISHII Kazuhiro
- Project Period (FY)
  2003 – 2004
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Hematology
- Research Institution
  Mie University
Expression of Ikaros isoforms in adult and childhood pre-B acute lymphoblastic leukemias.Principal Investigator
- Principal Investigator
  
  NISHII Kazuhiro
- Project Period (FY)
  2001 – 2002
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Hematology
- Research Institution
  Mie University

All 2007 2006 2004 2003 Other

All Journal Article

[Journal Article] Successful treatment of imatinib combined with less intensive chemotherapy (vincristine and dexamethasone) as induction therapy in a very elderly patient with Philadelphia chromosome-positive acute lymphoblastic leukienmia.2007
- Author(s)
  Nishii K, Sakakura M, Tsukada T, Ryuu H, Katayama N
- Journal Title
  
  International Journal of Hematology 85
  
  Pages: 273-274
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17590992
[Journal Article] Detection of CBFB/MYH11 fusion gene in acute myeloid leukemia (AML) without inv(16); incidence in 218 Japanese AML cases.2007
- Author(s)
  Monma F, Nishii K, Shiga J, Sugahara H, Watanabe Y, Kawakami K, Hosokai N, Yamamori S, Shiku H, Katayama N
- Journal Title
  
  Leukemia Research 31
  
  Pages: 471-476
- Data Source
  KAKENHI-PROJECT-17590992
[Journal Article] Expression of the JAK2 V617F mutation is not found in de novo AML and MDS but is detected in MDS-derived leukemia of megakaryoblastic nature.2007
- Author(s)
  Nishii K, Nanbu R, Lorenzo F 5^<th>, Monma F, et al.
- Journal Title
  
  Leukemia 21
  
  Pages: 1337-1338
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17590992
[Journal Article] Detection of CBFB/MYH11 fusion gene in acute myeloid leukemia (AML) without inv(16); incidence in 218 Japanese AML cases.2007
- Author(s)
  Monma F, Nishii K., Shiga J, Sugahara H, Watanabe Y, et al.
- Journal Title
  
  Leukemia Research 31
  
  Pages: 471-476
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17590992
[Journal Article] Expression of the JAK2 V617F mutation is not found in de novo AML and MDS but is detected in MDS-derived leukemia of megakaryoblastic nature.2007
- Author(s)
  Nishii K, Nanbu R, Lorenzo F 5th, Monma F, Kato K, Ryuu H, Katayama N
- Journal Title
  
  Leukemia 21
  
  Pages: 1337-1338
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17590992
[Journal Article] Successful treatment of imatinib combined with less intensive chemotherapy (vincristine and dexamethasone) as induction therapy in a very elderly patient with Philadelphia chromosome-positive acute lymphoblastic leukemia.2007
- Author(s)
  Nishii K, Sakakura M, tsukada T, Hyuu R, Katayama N
- Journal Title
  
  Int J Hematol 85
  
  Pages: 273-274
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17590992
[Journal Article] Detection of CBFB/MYH11 fusion gene in acute myeloid leukemia (AML) without inv(16); incidence in 218 Japanese AML cases.2007
- Author(s)
  Monma F, Nishii K, Shiga J, Sugahara H, Watanabe y Kawakami K, Hosokai N, Yamamori S, Shiku H, Katayama N
- Journal Title
  
  Leuk Res 31
  
  Pages: 471-476
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17590992
[Journal Article] Molecular and phenatypic analysis of Philadelphia chromosome-positive bilineage leukemia : possibility of a lineage switch from T-lymphoid leukemic progenitor to myeloid cells.2006
- Author(s)
  Monma F, Nishii K, Ezuki S, Miyazaki T, Yamamori S, Usui E, Sugimoto Y, et al.
- Journal Title
  
  Cancer genetics and Cytogenetics 164
  
  Pages: 118-121
- Data Source
  KAKENHI-PROJECT-17590992
[Journal Article] Granulocytic sarcoma of mesentery in acute myeloid leukemia with CBFB/MYH11 fusion gene but not inv(16) chromosome : case report and review of literature.2006
- Author(s)
  Fujieda A, Nishii K, Tamaru T, Otsuki S, Kobayasi K, Monma F, Ohishi K, Nakase K, Katayama N, Shiku H
- Journal Title
  
  Leuk Res 30
  
  Pages: 1053-1057
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17590992
[Journal Article] Mutational analysis of the KIT gene in myelodysplastic syndrome (MDS) and MDS-derived leukemia.2006
- Author(s)
  Lorenzo F 5^<th>, Nishii K, Monma F, Kuwagata S, Usui E, Shiku H
- Journal Title
  
  Leukemia Research 30
  
  Pages: 1235-1239
- Data Source
  KAKENHI-PROJECT-17590992
[Journal Article] Molecular analysis of PDGFRA/B genes in core binding factor leukemia with eosinophilia.2006
- Author(s)
  Monma F, Nishii K, Lorenzo F 5th, Usui E, Ueda Y, Katayama N, et al.
- Journal Title
  
  European Journal of Hematology 76
  
  Pages: 18-22
- Data Source
  KAKENHI-PROJECT-17590992
[Journal Article] Granulocytic sarcoma of mesentery in acute myeloid leukemia with CBFB/MYH11 fusion gene but not inv(16) chromosome : case report and review of literature.2006
- Author(s)
  Fujieda A, Nishii K, Tamaru T, Otsuki S, Kobayasi K, Monma F, Ohishi K, NakaseK, Katayama N, Shiku H
- Journal Title
  
  Leukemia Research 30
  
  Pages: 1053-1057
- Data Source
  KAKENHI-PROJECT-17590992
[Journal Article] Granulocytic sarcoma of mesentery in acute myeloid leukemia with CBFB/MYH11 fusion gene but not inv(16) chromosome : case report and review of literature.2006
- Author(s)
  Fujieda A, Nishii K., Tamaru T, Otsuki S, Kobayasi K, et al.
- Journal Title
  
  Leukemia Research 30
  
  Pages: 1053-1057
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17590992
[Journal Article] Low p53 expression of acute myelocytic leukemia cells with t(8;21) chromosome abnormality : Association with low p14(ARF) expression.2006
- Author(s)
  Shikami M, Miwa H, Nishii K, Kyo T, Tanaka I, Shiku H, Kita K, Nitta M
- Journal Title
  
  Leukemia Research 30
  
  Pages: 379-383
- Data Source
  KAKENHI-PROJECT-17590992
[Journal Article] Molecular analysis of PDGFRα/β genes in core binding factor leukemia with eosinophilia.2006
- Author(s)
  Monma F, Nishii K, Lorenzo F 5th, Usui E, Ueda Y, Katayama N, Watanabe Y, Kawakami k, Oka K, Mitani H, Sekine T, Tamaki S, Mizutani M, Yagasaki F, Doki N, Miyawaki S, Shiku H
- Journal Title
  
  Eur J Haematol 76
  
  Pages: 18-22
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17590992
[Journal Article] Mutational analysis of the KIT gene in myelodysplastic syndrome (MDS) and MDS-derived leukemia.2006
- Author(s)
  Lorenzo F 5th, Nishii K, Monma F, Kuwagata S, Usui E, Shiku H
- Journal Title
  
  Leuk Res 30
  
  Pages: 1235-1239
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17590992
[Journal Article] Molecular analysis of PDGFRα/β genes in core binding factor leukemia with eosinophilia.2006
- Author(s)
  Monma F, Nishii K, Lorenzo F 5th, Usui E, Ueda Y, Katayama N, et al.
- Journal Title
  
  European Journal of Haematology 76
  
  Pages: 18-22
- Data Source
  KAKENHI-PROJECT-17590992
[Journal Article] Molecular analysis of PDGFRA/B genes in core binding factor leukemia with eosinophilia.2006
- Author(s)
  Monma F, Nishii K, Lorenzo F 5th, Usui E, Ueda Y, et al.
- Journal Title
  
  European Journal of Hematology 76
  
  Pages: 18-22
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17590992
[Journal Article] Up-regulated production of IL-6, but not IL-10, by Interferon-□□□induces SOCS3 expression and attenuates STAT1 phosphorylation in myeloma cells.2004
- Author(s)
  Usui E, Nishii K, Katayama N, et al.
- Journal Title
  
  Hematology J 5
  
  Pages: 505-512
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15591002
[Journal Article] Up-regulated production of IL-6, but not IL-10, by Interferon- □induces SOCS3 expression and attenuates STAT1 phosohorylation in mveloma cells.2004
- Author(s)
  Usui E, Nishii K, et al.
- Journal Title
  
  Haematologica / Hematology J 5
  
  Pages: 505-512
- Data Source
  KAKENHI-PROJECT-15591002
[Journal Article] Activities of granulocyte-macrophage colony-stimulating factor and interleukein-3 on monocytes2004
- Author(s)
  Suzuki H, Katayama N, Ikuta Y, Mukai K, Fujita A, Mitani H, Araki H, Miyashita H, Hoshino N, Nishikawa H, Nishii K, et al.
- Journal Title
  
  Am J Hematol 75
  
  Pages: 179-189
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15591002
[Journal Article] Reprogramming of human post-mitotic neutrophils into macrophages by growth factors.2004
- Author(s)
  Araki H, Katayama N, Yamashita Y, Mano H, Fujieda A, Usui E, Mitani H, Ohishi K, Nishii K, et al.
- Journal Title
  
  Blood 103
  
  Pages: 2973-2980
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15591002
[Journal Article] Case of chronic-phase chronic myelogenous leukemia with an abdominal hematopoietic tumor of leukemic clone origin.2004
- Author(s)
  Sakakura M, OhishiK, Nomura K, Katayama N, Nishii K, et al.
- Journal Title
  
  Am J Hematol 77
  
  Pages: 157-170
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15591002
[Journal Article] Hemostatic abnormalities and changes following bone marrow transplantation.2004
- Author(s)
  Matsumoto T, Wada H, Nishiyama H, Hirano T, Sakakura M, Nishii K, et al.
- Journal Title
  
  Clin Appl Thromb Hemost 10
  
  Pages: 341-350
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15591002
[Journal Article] Acute myeloid leukemia with t(8;21)(q22;q22) manifesting as granulocytic sarcomas in the rhinopharynx at relapse after high-dose cytarabine consolidation : case report and review of the literature.2004
- Author(s)
  Sugimoto Y, Nishii K, Sakakura M, et al.
- Journal Title
  
  Hematology J 5
  
  Pages: 84-89
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15591002
[Journal Article] CD21S antigen expression in tumor cells of diffuse large B-cell lymphomas is an independent prognostic factor indicating better overall survival.2004
- Author(s)
  Ogawa S, Yamaguchi M, Oka K, Taniguchi M, Ito M, Nishii K, et al.
- Journal Title
  
  Br J Haematol 125
  
  Pages: 180-186
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15591002
[Journal Article] Up-regulated production of IL-6, but not IL-10, by Interferon-a induces SOCS3 expression and attenuates STAT1 phosphorylation in myeloma cells.2004
- Author(s)
  Usui E, Nishii K, Katayama N, et al.
- Journal Title
  
  Hematology J 5
  
  Pages: 505-512
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15591002
[Journal Article] Acute myeloid leukemia with t(8;21)(q22;q22) manifesting as granulocytic sarcomas in the rhinopharynx at relapse after high-dose cytarabine consolidation ; case report and review of the literature.2004
- Author(s)
  Sugimoto Y, Nishii K, et al.
- Journal Title
  
  Haematologica / Hematology J 5
  
  Pages: 84-89
- Data Source
  KAKENHI-PROJECT-15591002
[Journal Article] AML with t(8;21) and trisomy 4 : possible involvement of c-kit?/Reply to SE Langabeer et al.2003
- Author(s)
  Lorenzo F V, Nishii K, et al.
- Journal Title
  
  Leukemia 17
  
  Pages: 1915-1916
- Data Source
  KAKENHI-PROJECT-15591002
[Journal Article] Identification of signature genes by microarray for acute myeloid leukemia without maturation and acute promyelocytic leukemia with t(15;17)(q22;q12)(PML/RARA□).2003
- Author(s)
  Morikawa J, Li H, Kim S, Nishii K, et al.
- Journal Title
  
  Int J Oncol 23
  
  Pages: 617-625
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15591002
[Journal Article] Characteristics of t(8;21) acute myeloid leukemia(AML) with additional chromosomal abnormality : Concomitant trisomy 4 may constitute a distinctive subtype of t(8;21) AML.2003
- Author(s)
  Nishii K, Usui E, Katayama N, et al.
- Journal Title
  
  Leukemia 17
  
  Pages: 731-737
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15591002
[Journal Article] Characteristics of t(8;21) acute myeloid leukemia (AML) with additional chromosomal or abnormality : Concomitant trisomy 4 may constitute a distinctive subtype of t(8;21;21) AML2003
- Author(s)
  Nishii K, Usui E, et al.
- Journal Title
  
  Leukemia 17
  
  Pages: 731-737
- Data Source
  KAKENHI-PROJECT-15591002
[Journal Article] Dual mutations in the AML1 and FLT3 genes are associated with leukemogenesis in acute myeloblastic leukemia for the M0 subtype.2003
- Author(s)
  Matsuno N, Osato M, Yamashita N, Yanagida M, Nanri T, Fukushima T, Motoji T, Kusumoto S, Towatari M, Suzuki R, Naoe T, Nishii K, et al.
- Journal Title
  
  Leukemia 17
  
  Pages: 2492-2499
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15591002
[Journal Article] Hypermethylation of death-associated protein (DAP) kinase CpG island is frequent not only in B-cell but also in T-cell and natural killer (NK)/T-cell malignancies.2003
- Author(s)
  Nakatsuka S-I, Takakuwa T, Tomita Y, Hoshida Y, Nishiu M, Yamaguchi M, Nishii K, Yang W-I, Aozasa K
- Journal Title
  
  Cancer Sci 94
  
  Pages: 87-91
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15591002
[Journal Article] AML with t(8;21) and trisomy 4 : possible involvement of c-kit? / Reply to SE Langabeer et al.2003
- Author(s)
  Lorenzo F V, Nishii K. Usui E, et al.
- Journal Title
  
  Leukemia 17
  
  Pages: 1915-1916
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15591002
[Journal Article] AML with t(8;21) and trisomy 4 : possible involvement of c-kit?2003
- Author(s)
  Lorenzo FV, Nishii K, Usui E, et al.
- Journal Title
  
  Leukemia(Reply to SE Langabeer et al.) 17
  
  Pages: 1915-1916
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15591002
[Journal Article] Characteristics of t(8;21) acute myeloid leukemia (AML) with additional chromosomal abnormality : Concomitant trisomy 4 may constitute a distinctive subtype of t(8;21) AML.2003
- Author(s)
  Nishii K, Usui E, Katayama N, et al.
- Journal Title
  
  Leukemia 17
  
  Pages: 731-737
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15591002
[Journal Article] Mutational analysis of the KIT gene in myelodysplastic syndrome(MDS) and MDS-derived leukemia.
- Author(s)
  Lorenzo F 5^<th>, Nishii K, Monma F, Kuwagata S, Usui E, Shiku H
- Journal Title
  
  Leukemia Research (in press)
- Data Source
  KAKENHI-PROJECT-17590992
[Journal Article] Granulocytic sarcoma of mesentery in acute myeloid leukemia with CBFB/MYH11 fusion gene but not inv(16) chromosome : case report and review of literature.
- Author(s)
  Fujieda A, Nishii K, Tamaru T, Otsuki S, Kobayasi K, Monma F, Ohishi K, Nakase K, Katayama N, Shiku H
- Journal Title
  
  Leukemia Research (in press)
- Data Source
  KAKENHI-PROJECT-17590992
[Journal Article] Successful treatment of imatinib combined with less intensive chemotherapy (vincristine and dexamethasone) as induction therapy in a very elderly patient with Philadelphia chromosome-positive acute Iymphoblastic leukemia.
- Author(s)
  Nishii K, Sakakura M, tsukada T, Ryuu H, Katayama N
- Journal Title
  
  International Journal of Hematology (in press)
- Data Source
  KAKENHI-PROJECT-17590992
[Journal Article] Bilateral osteonecrosis of the head of the femur in a young patient with acute promyelocytic leukemia during treatment with retinoic acid.
- Author(s)
  Sakakura M, Nishii K, Usui E, Monma F, Tsukada T, Shiku H
- Journal Title
  
  Internal Journal Hematology (in press)
- Data Source
  KAKENHI-PROJECT-17590992
[Journal Article] Expression of the JAK2 V617F mutation is not found in de novo AML and MDS but is detected in MDS-derived leukemia of megakaryoblastic nature.
- Author(s)
  Nishii K, Nanbu R, Lorenzo F 5^<th>, Monma F, Kato K, Ryuu H, Katayama N
- Journal Title
  
  Leukemia (in press)
- Data Source
  KAKENHI-PROJECT-17590992

NISHII Kazuhiro 西井 一浩

Research Projects

Research Products

Characteristics of the leukemia with KIT mutationPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Active mutation of c-kit gene in acute myeloid leukemiaPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Expression of Ikaros isoforms in adult and childhood pre-B acute lymphoblastic leukemias.Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Successful treatment of imatinib combined with less intensive chemotherapy (vincristine and dexamethasone) as induction therapy in a very elderly patient with Philadelphia chromosome-positive acute lymphoblastic leukienmia.2007

Author(s)

Journal Title

Description

Data Source

[Journal Article] Detection of CBFB/MYH11 fusion gene in acute myeloid leukemia (AML) without inv(16); incidence in 218 Japanese AML cases.2007

Author(s)

Journal Title

Data Source

[Journal Article] Expression of the JAK2 V617F mutation is not found in de novo AML and MDS but is detected in MDS-derived leukemia of megakaryoblastic nature.2007

Author(s)

Journal Title

Description

Data Source

[Journal Article] Detection of CBFB/MYH11 fusion gene in acute myeloid leukemia (AML) without inv(16); incidence in 218 Japanese AML cases.2007

Author(s)

Journal Title

Description

Data Source

[Journal Article] Expression of the JAK2 V617F mutation is not found in de novo AML and MDS but is detected in MDS-derived leukemia of megakaryoblastic nature.2007

Author(s)

Journal Title

Description

Data Source

[Journal Article] Successful treatment of imatinib combined with less intensive chemotherapy (vincristine and dexamethasone) as induction therapy in a very elderly patient with Philadelphia chromosome-positive acute lymphoblastic leukemia.2007

Author(s)

Journal Title

Description

Data Source

[Journal Article] Detection of CBFB/MYH11 fusion gene in acute myeloid leukemia (AML) without inv(16); incidence in 218 Japanese AML cases.2007

Author(s)

Journal Title

Description

Data Source

[Journal Article] Molecular and phenatypic analysis of Philadelphia chromosome-positive bilineage leukemia : possibility of a lineage switch from T-lymphoid leukemic progenitor to myeloid cells.2006

Author(s)

Journal Title

Data Source

[Journal Article] Granulocytic sarcoma of mesentery in acute myeloid leukemia with CBFB/MYH11 fusion gene but not inv(16) chromosome : case report and review of literature.2006

Author(s)

Journal Title

Description

Data Source

[Journal Article] Mutational analysis of the KIT gene in myelodysplastic syndrome (MDS) and MDS-derived leukemia.2006

Author(s)

Journal Title

Data Source

[Journal Article] Molecular analysis of PDGFRA/B genes in core binding factor leukemia with eosinophilia.2006

Author(s)

Journal Title

Data Source

[Journal Article] Granulocytic sarcoma of mesentery in acute myeloid leukemia with CBFB/MYH11 fusion gene but not inv(16) chromosome : case report and review of literature.2006

Author(s)

Journal Title

Data Source

[Journal Article] Granulocytic sarcoma of mesentery in acute myeloid leukemia with CBFB/MYH11 fusion gene but not inv(16) chromosome : case report and review of literature.2006

Author(s)

Journal Title

Description

NISHII Kazuhiro 西井一浩