habano wataru 幅野渉

… Alternative Names

Habano Wataru 幅野渉

HABANO Wataru 幅野渉

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Researcher Number	50332979
Other IDs
External Links
Affiliation (Current)	2026: 岩手医科大学, 薬学部, 教授
Affiliation (based on the past Project Information) *help	2022 – 2024: 岩手医科大学, 薬学部, 教授 2019 – 2021: 岩手医科大学, 薬学部, 准教授 2007 – 2017: Iwate Medical University, School of Pharmaceutical, Associate Professor 2002 – 2006: 岩手医科大学, 医学部, 助手 2004: Iwate Medical University, Assistant professor, 医学部, 講師 2003: 岩手医大学, 医学部, 助手
Review Section/Research Field	Principal Investigator Human pathology / Basic Section 47060:Clinical pharmacy-related / Human pathology Except Principal Investigator Human pathology / Medical systems / General anatomy (including Histology/Embryology) / Circulatory organs internal medicine
Keywords	Principal Investigator エピジェネティクス / 腺管分離法 / DNAメチル化 / 核内受容体 / aneuploidy / ストレス応答 / エピゲノム / 癌間質 / colorectal cancer / crypt isolation … More / DNA methylation / chromosomal instability / multiploid / 大腸癌 / 染色体不安定化 / 個別化薬物治療 / 薬物代謝酵素 / 薬物代謝変動 / 薬剤感受性 / ゲノム不安定化 / 癌 / 癌抑制遺伝子 / 呼吸鎖複合体遺伝子 / SDHD / 呼吸鎖複合体 / ミトコンドリアDNA / 消化器癌 … More Except Principal Investigator RT dispersion / 16s ribosomal DNA / Brachyspira aalborgi / PCR / Brachyspira pilosicoli / SNP / 大腸癌 / signal-averaged vector-nroiected ECG / spectral analysis / late potential / myocardial injury / magnetocardiograph / drug-induced QT prolongation / single nucleotide polymorphism / 傷害心筋 / 抗がん剤 / カリウムチャンネル / 薬剤誘発QT延長 / 一塩基遺伝子多型 / 致死的不整脈 / 遺伝子-塩基多計 / 高分解能心電計 / スペクトルム解析 / Late potential / RTdispersion / 心筋傷害 / 心磁計 / 薬剤性QT延長 / 遺伝子一塩基多計 / NADHoxidase / Bacterial colitis / Zoonotic infection / Intestinal spirochaetosis / 大腸生検 / NADH oxidase / Brachyspira aaloborgi / intestinal spirochetosis / 菌種同定 / 人畜共通感染症 / 細菌性大腸炎 / Bracyspira aalborgi / Intestinal spirochetosis / kidney / organogenesis / rat / zebrafish / transcription factor / lymphatic vessel / vasculogenesis / angiogenesis / 遺伝子発現 / 血管内皮細胞 / 脳血管 / イメージング / 二光子顕微鏡 / ゼブラフィッシュ / 血管伸長ガイダンス因子 / 血球分化 / 血管 / 腎 / 脳 / ラット / ゼブラフイッシュ / 転写因子 / リンパ管 / 脈管新生 / 血管新生 / warfarin / artificial valve replacement / OligoArrav / real-time PCR / anti-coagulation therapy / CYP2C9 genotype / DNAアレイ / 人工弁 / 薬物療法 / CYP2C9 遺伝子多型 / 個別化医療 / CYP2C9 / 人工弁置換術 / OligoArray法 / real-time PCR法 / XII因子遺伝子 / ワーファリン / CYP2C9P / p53 / AI / 右側 / 左側 / CD10 / MUC5AC / メチル化 / 遺伝子解析 / 胃癌 / 腺管分離法 / 単一腺管 / allelic imbalance、 / FISH / 腺管分離 Less

Novel roles of DNA methylation in stress response mediated by nuclear receptor AhRPrincipal Investigator
- Principal Investigator
  
  Habano Wataru
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 47060:Clinical pharmacy-related
- Research Institution
  Iwate Medical University
Development of epigenome sensor model mediated by nuclear receptor pathwayPrincipal Investigator
- Principal Investigator
  
  Habano Wataru
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 47060:Clinical pharmacy-related
- Research Institution
  Iwate Medical University
Analysis of epigenetic alterations in tumor stromal cells and application in cancer diagnosis and treatment.Principal Investigator
- Principal Investigator
  
  HABANO WATARU
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Human pathology
- Research Institution
  Iwate Medical University
Analysis of epigenetic mechanisms on the regulation of drug metabolizing enzymes and its application to personalized drug therapyPrincipal Investigator
- Principal Investigator
  
  HABANO WATARU
- Project Period (FY)
  2012 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Human pathology
- Research Institution
  Iwate Medical University
Estimation of the role of genomic instability on drug response and its application for cancer chemotherapy.Principal Investigator
- Principal Investigator
  
  HABANO Wataru
- Project Period (FY)
  2009 – 2011
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Human pathology
- Research Institution
  Iwate Medical University
Molecular analysis of single tumor gland in the gastrointestinal cancers
- Principal Investigator
  
  SUGAI Tamotsu
- Project Period (FY)
  2007 – 2008
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Human pathology
- Research Institution
  Iwate Medical University
Early screening of myocardial injury and lethal arrhythmia by 64-channel magnetocardiography and genetical predisposition
- Principal Investigator
  
  NAKAI Kenji
- Project Period (FY)
  2006 – 2007
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Medical systems
- Research Institution
  Iwate Medical University
Crypt FISH-腺管分離材料を用いたFISH法による染色体異常の解析-
- Principal Investigator
  
  上杉憲幸
- Project Period (FY)
  2005 – 2006
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  Human pathology
- Research Institution
  Iwate Medical University
Research on molecular mechanisms of chromosomal instability in tumorsPrincipal Investigator
- Principal Investigator
  
  HABANO Wataru
- Project Period (FY)
  2005 – 2006
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Human pathology
- Research Institution
  Iwate Medical University
Morphological and molecular biological analyses for the mechanism of vascular development in the embryogenesis
- Principal Investigator
  
  HITOMI Jiro
- Project Period (FY)
  2004 – 2006
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  General anatomy (including Histology/Embryology)
- Research Institution
  Iwate Medical University
Intestinal Spirochaetosis : Clinico-pathological study and identification of species by PCR
- Principal Investigator
  
  NAKAMURA Shin-ichi
- Project Period (FY)
  2004 – 2005
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Human pathology
- Research Institution
  Iwate Medical University
A development of oligonucleotide based DNA array for CYP2C9 genotyping for individual therapy in patients with valve replacement receiving warfarin therapy
- Principal Investigator
  
  NAKAI Kenji
- Project Period (FY)
  2003 – 2004
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Circulatory organs internal medicine
- Research Institution
  Iwate Medical University
ヒト腫瘍におけるミトコンドリア呼吸鎖複合体遺伝子の機能異常の検索と分子機構の解明Principal Investigator
- Principal Investigator
  
  幅野渉
- Project Period (FY)
  2002 – 2003
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Human pathology
- Research Institution
  Iwate Medical University

[Journal Article] DNAメチル化による核内受容体AhR経路の制御-ストレス応答と薬物相互作用における意義-2024
- Author(s)
  幅野　渉
- Journal Title
  
  医薬品相互作用研究
  
  Volume: 48 Pages: 108-113
- Data Source
  KAKENHI-PROJECT-22K06728
[Journal Article] Gastroblastoma mimics the embryonic mesenchyme of the foregut: a case report2023
- Author(s)
  Sugimoto Ryo、Uesugi Noriyuki、Yamada Noriyuki、Osakabe Mitsumasa、Baba Shigeaki、Yanagawa Naoki、Akiyama Yuji、Habano Wataru、Sasaki Akira、Oda Yoshinao、Sugai Tamotsu
- Journal Title
  
  Diagnostic Pathology
  
  Volume: 18 Issue: 1 Pages: 24-24
- DOI
  10.1186/s13000-023-01310-2
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K06728, KAKENHI-PROJECT-20K07412
[Journal Article] The Regulation Pathway of VEGF Gene Expression Is Different between 2D Cells and 3D Spheroids in Human Lung Cancer Cells2023
- Author(s)
  Onodera Ryo、Jimma Yoko、Suzuki Anna、Habano Wataru、Ozawa Shogo、Terashima Jun
- Journal Title
  
  Biological and Pharmaceutical Bulletin
  
  Volume: 46 Issue: 4 Pages: 608-613
- DOI
  10.1248/bpb.b22-00772
- ISSN
  0918-6158, 1347-5215
- Year and Date
  2023-04-01
- Language
  English
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K06728
[Journal Article] Aryl hydrocarbon receptor as a DNA methylation reader in the stress response pathway2022
- Author(s)
  Habano Wataru、Miura Toshitaka、Terashima Jun、Ozawa Shogo
- Journal Title
  
  Toxicology
  
  Volume: 470 Pages: 153154-153154
- DOI
  10.1016/j.tox.2022.153154
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K07200
[Journal Article] β-naphthoflavone-induced upregulation of CYP1B1 expression is mediated by the preferential binding of aryl hydrocarbon receptor to unmethylated xenobiotic responsive elements2021
- Author(s)
  Miura Toshitaka、Onodera Ryo、Terashima Jun、Ozawa Shogo、Habano Wataru
- Journal Title
  
  Experimental and Therapeutic Medicine
  
  Volume: 22 Issue: 6 Pages: 1410-1410
- DOI
  10.3892/etm.2021.10846
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K07200
[Journal Article] A genome‐wide analysis of the molecular alterations occurring in the adenomatous and carcinomatous components of the same tumor based on the adenoma?carcinoma sequence2021
- Author(s)
  Sugai Tamotsu、Osakabe Mitsumasa、Habano Wataru、Tanaka Yoshihito、Eizuka Makoto、Sugimoto Ryo、Yanagawa Naoki、Matsumoto Takayuki、Suzuki Hiromu
- Journal Title
  
  Pathology International
  
  Volume: 71 Issue: 9 Pages: 582-593
- DOI
  10.1111/pin.13129
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K07200, KAKENHI-PROJECT-19H03518, KAKENHI-PROJECT-20K07412
[Journal Article] Cellular irinotecan resistance in colorectal cancer and overcoming irinotecan refractoriness through various combination trials including DNA methyltransferase inhibitors: a review2021
- Author(s)
  Ozawa Shogo、Miura Toshitaka、Terashima Jun、Habano Wataru
- Journal Title
  
  Cancer Drug Resistance
  
  Volume: 4 Pages: 946-64
- DOI
  10.20517/cdr.2021.82
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K07200
[Journal Article] Recent Progress in Prediction Systems for Drug-induced Liver Injury Using In vitro Cell Culture2021
- Author(s)
  Ozawa Shogo、Miura Toshitaka、Terashima Jun、Habano Wataru、Ishida Seiichi
- Journal Title
  
  Drug Metabolism Letters
  
  Volume: 14 Issue: 1 Pages: 25-40
- DOI
  10.2174/1872312814666201202112610
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K07200
[Journal Article] Aryl Hydrocarbon Receptor Mediates Cell Proliferation Enhanced by Benzo[a]pyrene in Human Lung Cancer 3D Spheroids2019
- Author(s)
  Jimma Yoko、Jimma Keiko、Yachi Maako、Hakata Shuko、Habano Wataru、Ozawa Shogo、Terashima Jun
- Journal Title
  
  Cancer Investigation
  
  Volume: 37 Issue: 8 Pages: 367-375
- DOI
  10.1080/07357907.2019.1655760
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K07200
[Journal Article] Molecular profiling and genome-wide analysis based on somatic copy number alterations in advanced colorectal cancers2018
- Author(s)
  Sugai T, Takahashi Y, Eizuka M, Sugimoto R, Fujita Y, Habano W, Otsuka K, Sasaki A, Yamamoto E, Matsumoto T, Suzuki H.
- Journal Title
  
  Molecular Carcinogenesis
  
  Volume: 57 Issue: 3 Pages: 451-461
- DOI
  10.1002/mc.22769
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15K08383, KAKENHI-PROJECT-17K08700, KAKENHI-PROJECT-15K08973
[Journal Article] Molecular subtypes of colorectal cancers determined by PCR-based analysis.2017
- Author(s)
  Sugai T, Eizuka M, Takahashi Y, Fukagawa T, Habano W, Yamamoto E, Akasaka R, Otuska K, Matsumoto T, Suzuki H.
- Journal Title
  
  Cancer Sci
  
  Volume: 108(3) Issue: 3 Pages: 427-434
- DOI
  10.1111/cas.13164
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15K08383, KAKENHI-PROJECT-17K08700, KAKENHI-PROJECT-15H04299, KAKENHI-PROJECT-15K08973
[Journal Article] Analysis of molecular alterations in laterally spreading tumors of the colorectum.2017
- Author(s)
  Sugai T, Habano W, Takagi R, Yamano H, Eizuka M, Arakawa N, Takahashi Y, Yamamoto E, Kawasaki K, Yanai S, Ishida K, Suzuki H, Matsumoto T.
- Journal Title
  
  J Gastroenterol
  
  Volume: 52 Issue: 6 Pages: 715-723
- DOI
  10.1007/s00535-016-1269-y
- NAID
  110006550042
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15K08383, KAKENHI-PROJECT-16K08655, KAKENHI-PROJECT-17K08700, KAKENHI-PROJECT-15H04299
[Journal Article] Molecular alterations in colorectal adenomas and intramucosal adenocarcinomas defined by high-density single-nucleotide polymorphism arrays.2017
- Author(s)
  Eizuka M, Sugai T, Habano W, Uesugi N, Takahashi Y, Kawasaki K, Yamamoto E, Suzuki H, Matsumoto T.
- Journal Title
  
  J Gastroenterol
  
  Volume: - Issue: 11 Pages: 1158-1168
- DOI
  10.1007/s00535-017-1317-2
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15K08383, KAKENHI-PROJECT-15K08973, KAKENHI-PROJECT-17K08700, KAKENHI-PROJECT-15H04299
[Journal Article] Analysis of the DNA methylation level of cancer-related genes in colorectal cancer and the surrounding normal mucosa.2017
- Author(s)
  Sugai T, Yoshida M, Eizuka M, Uesugii N, Habano W, Otsuka K, Sasaki A, Yamamoto E, Matsumoto T, Suzuki H.
- Journal Title
  
  Clin Epigenetics.
  
  Volume: 55 Issue: 1 Pages: 55-55
- DOI
  10.1186/s13148-017-0352-4
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K08700, KAKENHI-PROJECT-15H04299, KAKENHI-PROJECT-15K08383, KAKENHI-PROJECT-15K08973
[Journal Article] Clinicopathological and molecular alterations in early gastric cancers with the microsatellite instability-high phenotype2016
- Author(s)
  Sugimoto R, Sugai T, Habano W, Endoh M, Eizuka M, Yamamoto E, Uesugi N, Ishida K, Kawasaki T, Matsumoto T, Suzuki H.
- Journal Title
  
  Int J Cancer
  
  Volume: 1 Issue: 7 Pages: 1689-97
- DOI
  10.1002/ijc.29916
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15K08973, KAKENHI-PROJECT-25460414, KAKENHI-PROJECT-25460420, KAKENHI-PROJECT-25460463, KAKENHI-PROJECT-15H04299, KAKENHI-PROJECT-15K08383, KAKENHI-PROJECT-16K08654
[Journal Article] Combination of the histone deacetylase inhibitor depsipeptide and 5-fluorouracil upregulates major histocompatibility complex class II and p21 genes and activates caspase-3/7 in human colon cancer HCT-116 cells.2016
- Author(s)
  Okada K, Hakata S, Terashima J, Gamou T, Habano W, Ozawa S
- Journal Title
  
  Oncol Rep
  
  Volume: 36(4) Issue: 4 Pages: 1875-1885
- DOI
  10.3892/or.2016.5008
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15K08383
[Journal Article] Molecular differences in the microsatellite stable phenotype between left-sided and right-sided colorectal cancer.2016
- Author(s)
  Takahashi Y, Sugai T, Habano W, Ishida K, Eizuka M, Otsuka K, Sasaki A, Matsumoto T, Morikawa T, Unno M, Suzuki H.
- Journal Title
  
  Int J Cancer
  
  Volume: 139 Issue: 11 Pages: 2493-2501
- DOI
  10.1002/ijc.30377
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15H04299, KAKENHI-PROJECT-15K08383, KAKENHI-PROJECT-16K08655
[Journal Article] A CAR-responsive enhancer element locating approximately 31 kb upstream in the 5'-flanking region of rat cytochrome P450 (CYP) 3A1 gene2015
- Author(s)
  Gamou T, Habano W, Terashima J, Ozawa S.
- Journal Title
  
  Drug Metab Pharmacokinet.
  
  Volume: 30 Issue: 2 Pages: 188-197
- DOI
  10.1016/j.dmpk.2014.12.008
- NAID
  210000171579
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15K08383
[Journal Article] Analysis of DNA methylation landscape reveals the roles of DNA methylation in the regulation of drug metabolizing enzymes2015
- Author(s)
  Habano W, Kawamura K, Iizuka N, Terashima J, Sugai T, Ozawa S.
- Journal Title
  
  Clinical Epigenetics
  
  Volume: 7 Issue: 1 Pages: 105-105
- DOI
  10.1186/s13148-015-0136-7
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15K08383, KAKENHI-PROJECT-25460420
[Journal Article] CYP1A1 and CYP1A2 expression levels are differentially regulated in three-dimensional spheroids of liver cancer cells compared to two-dimensional monolayer cultures2015
- Author(s)
  Terashima J, Goto S, Hattori H, Hoshi S, Ushirokawa M, Kudo K, Habano W, Ozawa S.
- Journal Title
  
  Drug Metab Pharmacokinet.
  
  Volume: 30 Issue: 6 Pages: 434-440
- DOI
  10.1016/j.dmpk.2015.10.001
- NAID
  50014429984
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15K08383
[Journal Article] An aryl hydrocarbon receptor induces VEGF expression through ATF4 under glucose deprivation in HepG22013
- Author(s)
  Terashima J, Tachikawa C, Kudo K, Habano W, Ozawa S
- Journal Title
  
  BMC Mol Biol. 2013 Dec 12;14:27
  
  Volume: 14 Issue: 1 Pages: 27-27
- DOI
  10.1186/1471-2199-14-27
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24590451
[Journal Article] Altered expression of GADD45 genes during the development of chemical-mediated liver hypertrophy and liver tumor promotion in rats2011
- Author(s)
  Ozawa S, Gamou T, Habano W, et al
- Journal Title
  
  The Journal of Toxicological Sciences
  
  Volume: 36 Issue: 5 Pages: 613-623
- DOI
  10.2131/jts.36.613
- NAID
  10029481415
- ISSN
  0388-1350, 1880-3989
- Language
  English
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590402
[Journal Article] Super-induced gene expression of the N-methyl-D-aspartate receptor 2C subunit in chemical-induced hypertrophic liver in rats2011
- Author(s)
  Nemoto K, Tanaka T, Ikeda A, Ito S, Mizukami M, Hikida T, Gamou T, Habano W, Ozawa S, Inoue K, Yoshida M, Nishikawa A, Degawa M.
- Journal Title
  
  J Toxicol Sci
  
  Volume: 36(5) Pages: 507-14
- NAID
  10029481028
- Data Source
  KAKENHI-PROJECT-21590402
[Journal Article] Induction of CYP1 family members under low-glucose conditions requires AhR expression and occurs through the nuclear translocation of AhR2011
- Author(s)
  Terashima J, Habano W, Gamou T, Ozawa S.
- Journal Title
  
  Drug Metab Pharmacokinet
  
  Volume: 26(6) Pages: 577-83
- NAID
  130004933497
- Data Source
  KAKENHI-PROJECT-21590402
[Journal Article] Expression of connexins and the effect of retinoic acid in oral keratinocytes2011
- Author(s)
  Hatakeyama S, Mikami T, Habano W, Takeda Y
- Journal Title
  
  Journal of Oral Science
  
  Volume: 53 Issue: 3 Pages: 327-332
- DOI
  10.2334/josnusd.53.327
- NAID
  130001170659
- ISSN
  1343-4934, 1880-4926
- Language
  English
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590402
[Journal Article] Involvement of promoter methylation in the regulation of Pregnane X receptor in colon cancer cells2011
- Author(s)
  Habano W, Gamo T, Terashima J, Sugai T, Otsuka K, Wakabayashi G, Ozawa S.
- Journal Title
  
  BMC Cancer
  
  Volume: 11 Pages: 81-81
- NAID
  130004640031
- Data Source
  KAKENHI-PROJECT-21590402
[Journal Article] A genetic association between s3-aderenoceptor and cholinergic receptor muscarinic 3 polymorphisms in irritable bowel syndrome2011
- Author(s)
  Onodera S, Chiba T, Sugai T, Habano W.
- Journal Title
  
  Hepatogastroenterology
  
  Volume: 58(110-111) Pages: 1474-8
- Data Source
  KAKENHI-PROJECT-21590402
[Journal Article] Involvement of promoter methylation in the regulation of Pregnane X receptor in colon cancer cells2011
- Author(s)
  Habano W, et al.
- Journal Title
  
  BMC Cancer
  
  Volume: (印刷中)
- NAID
  130004640031
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590402
[Journal Article] Altered expression of GADD45 genes during the development of chemical-mediated liver hypertrophy and liver tumor promotion in rats2011
- Author(s)
  Ozawa S, Gamou T, Habano W, Inoue K, Yoshida M, Nishikawa A, Nemoto K, Degawa M.
- Journal Title
  
  J Toxicol Sci
  
  Volume: 36(5) Pages: 613-23
- NAID
  10029481415
- Data Source
  KAKENHI-PROJECT-21590402
[Journal Article] Induction of CYP1 Family Members under Low-glucose Conditions Requires AhR Expression and Occurs through the Nuclear Translocation of AhR2011
- Author(s)
  Terashima J, Habano W, Gamou T, Ozawa S
- Journal Title
  
  Drug Metabolism and Pharmacokinetics
  
  Volume: 26 Issue: 6 Pages: 577-583
- DOI
  10.2133/dmpk.DMPK-11-RG-054
- NAID
  130004933497
- ISSN
  1347-4367, 1880-0920
- Language
  English
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590402
[Journal Article] Super-induced gene expression of the N-methyl-D-aspartate receptor 2C subunit in chemical-induced hypertrophic liver in rats2011
- Author(s)
  Nemoto K, Tanaka T, Ikeda A, Ito S, Mizukami M, Hikida T, Gamou T, Habano W, et al
- Journal Title
  
  The Journal of Toxicological Sciences
  
  Volume: 36 Issue: 5 Pages: 507-514
- DOI
  10.2131/jts.36.507
- NAID
  10029481028
- ISSN
  0388-1350, 1880-3989
- Language
  English
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590402, KAKENHI-PROJECT-23590150
[Journal Article] Expression of connexins and the effect of retinoic acid in oral keratinocytes2011
- Author(s)
  Hatakeyama S, Mikami T, Habano W, Takeda Y.
- Journal Title
  
  J Oral Sci
  
  Volume: 53(3) Pages: 327-32
- NAID
  130001170659
- Data Source
  KAKENHI-PROJECT-21590402
[Journal Article] A genetic association between ss3-aderenoceptor and cholinergic receptor muscarinic 3 polymorphisms in irritable bowel syndrome2011
- Author(s)
  Onodera S, Chiba T, Sugai T, Habano W
- Journal Title
  
  Hepatogastroenterology
  
  Volume: 58 Issue: 110-111 Pages: 1474-1478
- DOI
  10.5754/hge10153
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590402
[Journal Article] Molecular analysis of gastric differentiated-type intramucosal and submucosal cancers2010
- Author(s)
  Sugai T, Habano W, Endoh M, Konishi Y, Akasaka R, Toyota M, Yamano H, Koeda K, Wakabayashi G, Suzuki K.
- Journal Title
  
  Int J Cancer
  
  Volume: 127(11) Pages: 2500-9
- Data Source
  KAKENHI-PROJECT-21590402
[Journal Article] Molecular analysis of gastric differentiated-type intramucosal and submucosal cancers.2010
- Author(s)
  Sugai T, Habano W, et al.
- Journal Title
  
  Int J Cancer (印刷中)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590402
[Journal Article] Human intestinal spirochaetosis in northern Japan2010
- Author(s)
  Sato H, Nakamura S, Habano W, Wakabayashi G, Adachi Y.
- Journal Title
  
  J Med Microbiol
  
  Volume: 59(Pt 7) Pages: 791-6
- Data Source
  KAKENHI-PROJECT-21590402
[Journal Article] Association between tumor necrosis factor-alpha and Fc-gamma receptor polymorphisms with infliximab in Crohn's disease.2010
- Author(s)
  Tomita K, Chiba T, Sugai T, Habano W.
- Journal Title
  
  Hepatogastroenterology
  
  Volume: 57(99-100) Pages: 535-9
- Data Source
  KAKENHI-PROJECT-21590402
[Journal Article] Molecular analysis of single isolated glands in gastric cancers and their surrounding gastric intestinal metaplastic mucosa.2010
- Author(s)
  Sugai T, Habano W, et al.
- Journal Title
  
  Oncol Rep 23(1)
  
  Pages: 25-33
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590402
[Journal Article] Molecular analysis of single isolated glands in gastric cancers and their surrounding gastric intestinal metaplastic mucosa2010
- Author(s)
  Sugai T, Habano W, Jiao YF, Toyota M, Suzuki H, Tsukahara M, Koizuka H, Akasaka R, Koeda K, Wakabayashi G, Suzuki K.
- Journal Title
  
  Oncol Rep
  
  Volume: 23(1) Pages: 25-33
- Data Source
  KAKENHI-PROJECT-21590402
[Journal Article] CYP1B1, but not CYP1A1, is downregulated by promoter methylation in colorectal cancers2009
- Author(s)
  Habano W, Gamo T, Sugai T, Otsuka K, Wakabayashi G, Ozawa S.
- Journal Title
  
  Int J Oncol
  
  Volume: 34(4) Pages: 1085-1
- Data Source
  KAKENHI-PROJECT-21590402
[Journal Article] Screening the single nucleotide polymorphisms in patients with internal carotid artery stenosis by oligonucleotide-based custom DNA array2009
- Author(s)
  Nakai K, Oyanagi M, Hitomi J, Ogasawara K, Inoue T, Kobayashi M, Nakai K, Suwabe A, Habano W, Baba T, Yoshida H, Ogawa A.
- Journal Title
  
  Bioinform Biol Insights
  
  Volume: 1 Pages: 63-9
- Data Source
  KAKENHI-PROJECT-21590402
[Journal Article] CYP1B1, but not CYP1A1, is downregulated by promoter methylation in colorectal cancers.2009
- Author(s)
  Habano W, et al.
- Journal Title
  
  Int J Oncol 34(4)
  
  Pages: 1085-1091
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590402
[Journal Article] 大腸癌における分子異常.2008
- Author(s)
  菅井有, 幅野渉
- Journal Title
  
  胃と腸 43-13
  
  Pages: 1965-1974
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590362
[Journal Article] Serrated Adenoma of the Colorectum Undergoes a Proliferation versus Differentiation Process2008
- Author(s)
  Yu-Fei Jiao, Shin-ichi Nakamura, Tamotsu Sugai, Noriyuki Yamada, Wataru Habano
- Journal Title
  
  New Conceptual Interpretation of Morphogenesis Oncology
  
  Pages: 127-134
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590362
[Journal Article] 大腸癌における分子異常2008
- Author(s)
  菅井有, 幅野渉
- Journal Title
  
  胃と腸 43(13)
  
  Pages: 1965-1974
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590362
[Journal Article] Novel approach for detecting global epigenetic alterations associcated with tumor cell aneuploidy2007
- Author(s)
  Habano W, Sugai T, Jiao Y-F, Nakamura S.
- Journal Title
  
  Int J Cancer 121
  
  Pages: 1487-1493
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590362
[Journal Article] 子宮内膜癌における腺管分離法を用いた単一癌腺管の分子病理学的解析2007
- Author(s)
  永沢崇幸, 菅井有, 庄子忠宏, 幅野渉, 杉山徹
- Journal Title
  
  岩手医誌 59(5)
  
  Pages: 333-46
- NAID
  110006550033
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590362
[Journal Article] 大腸側方発育型瘍の分子病理学的解析2007
- Author(s)
  高木亮, 菅井有, 山野泰穂, 幅野渉, 千葉俊美, 鈴木一幸
- Journal Title
  
  岩手医誌 59(5)
  
  Pages: 347-357
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590362
[Journal Article] Novel approach for detecting global epigenetic alterations associated with tumor cell aneuploidy.2007
- Author(s)
  Habano W, Sugai T, et. al.
- Journal Title
  
  Int J Cancer 121
  
  Pages: 1487-1493
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590362
[Journal Article] Analysis genetic alterations associated with DNA diploidy, aneuploidy and multiploidy in gastric cancers.2005
- Author(s)
  Sugai T, Habano W, Nakamura S, et al.
- Journal Title
  
  Oncology 68
  
  Pages: 548-557
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16590291
[Journal Article] Analysis of SMAD4/DPC4 gene alterations in multiploid colorectal carcinomas.2005
- Author(s)
  Ando T, Habano W, et al.
- Journal Title
  
  J Gastroenterol 40
  
  Pages: 708-715
- NAID
  10016671700
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16590291
[Journal Article] Analysis of allelic imbalances at multiple cancer-related chromosomal loci and microsatellite instability within the same tumor using a single tumor gland from colorectal carcinomas.2005
- Author(s)
  Sugai T, Habano W, Nakamura S. et al.
- Journal Title
  
  Int J Cancer 114
  
  Pages: 337-345
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16590291
[Journal Article] Ethnic Difference of Coronary Artery Disease-associated SNPs in Two Israeli Healthy Populations Using MALDI-TOF Mass Spectrometry.2004
- Author(s)
  Nakai K, Habano W, Nakai K, Fukushima N, Fujita T, Gurwitz D
- Journal Title
  
  Life Sciences 75
  
  Pages: 1003-1010
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15590768
[Journal Article] Ethnic Difference of Coronary Artery Disease-associated SNPs in Two Israeli Healthy Populations Using MALDI-TOF Mass Spectrometry2004
- Author(s)
  Nakai K, Habano W, Nakai K, Fukushima N, Fujita T, Gurwitz D
- Journal Title
  
  Life Sciences 75
  
  Pages: 1003-1010
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15590768
[Journal Article] Application of the crypt isolation technique to the flow cytometric analysis of DNA content in gastric carcinoma.2004
- Author(s)
  Jiao YF, Habano W, Nakamura S. et al.
- Journal Title
  
  Hum Pathol 35
  
  Pages: 587-593
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16590291
[Journal Article] Analysis microsatellite alterations in gastric carcinoma using the crypt isolation technique.2004
- Author(s)
  Jiao Yu, Habano W, Nakamura S, et al.
- Journal Title
  
  J Pathol 204
  
  Pages: 200-207
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16590291
[Journal Article] Three independent genetic profiles based on mucin expression in early differentiated-type gastric cancers - a new concept of genetic carcinogenesis of early differentiated-type adenocarcinomas.2004
- Author(s)
  Sugai T, Habano W, Nakamura S. et al.
- Journal Title
  
  Mod Pathol 17
  
  Pages: 1223-1234
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16590291
[Journal Article] Analysis of Ki-ras gene mutations within the same tumor using a singlet tumor crypt in colorectal carcinomas.2004
- Author(s)
  Ishii M, Habano W, Nakamura S et al.
- Journal Title
  
  J Gastroenterol 39
  
  Pages: 544-549
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16590291
[Journal Article] A novel approach for detecting global epigenetic alterations associated with tumor cell aneuploidy
- Author(s)
  Habano W. et al.
- Journal Title
  
  Int J Cancer (印刷中)
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17590313
[Journal Article] A novel approach for detecting global epigenetic alterations associated with tumor cell aneuploidy
- Author(s)
  Habano W. et al.
- Journal Title
  
  Int J Cancer (印刷中)
- Data Source
  KAKENHI-PROJECT-17590313
[Journal Article] A novel approach for detecting global epigenetic alterations associated with tumor cell aneuploidy
- Author(s)
  Habano W. et al.
- Journal Title
  
  International Journal of Cancer (in press)
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17590313
[Patent] CYP2C9遺伝子および第XII因子遺伝子の一塩基多型を含む領域を同時に増幅するためのプライマーセット2005
- Inventor(s)
  中居賢司, 幅野渉, 中居恵子, 守屋彰悟
- Industrial Property Rights Holder
  日清紡績株式会社
- Industrial Property Number
  2005-122128
- Filing Date
  2005-04-20
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15590768
[Presentation] DNAメチル基転移酵素阻害剤併用によるヒト大腸がん細胞株のイリノテカン感受性増強とアポトーシス関連タンパクの発現変動2016
- Author(s)
  博多修子、寺島潤、幅野渉、小澤正吾
- Organizer
  第75回日本癌学会学術総会
- Place of Presentation
  横浜
- Year and Date
  2016-10-06
- Data Source
  KAKENHI-PROJECT-15K08383
[Presentation] AhRの肺がん細胞における遺伝子発現制御の解析2016
- Author(s)
  神馬瑤子、寺島潤、幅野渉、小澤正吾
- Organizer
  第75回日本癌学会学術総会
- Place of Presentation
  横浜
- Year and Date
  2016-10-06
- Data Source
  KAKENHI-PROJECT-15K08383
[Presentation] Analysis of DNA methylation landscape reveals the roles of DNA methylation in the regulation of drug metabolizing enzymes2015
- Author(s)
  幅野渉、寺島潤、小澤正吾
- Organizer
  日本薬物動態学会第30回年回
- Place of Presentation
  東京
- Year and Date
  2015-11-12
- Data Source
  KAKENHI-PROJECT-15K08383
[Presentation] オミクス情報を活用した薬物代謝変動要因の探索2014
- Author(s)
  幅野渉
- Organizer
  日本臨床検査医学会東北支部総会
- Place of Presentation
  盛岡
- Year and Date
  2014-08-09
- Invited
- Data Source
  KAKENHI-PROJECT-24590451
[Presentation] 薬物動態関連遺伝子のエピジェネティックな発現制御：プロモーターメチル化を中心に2013
- Author(s)
  幅野渉、小澤正吾
- Organizer
  日本薬物動態学会第28回年会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-24590451
[Presentation] Epigenetic regulation of the UGT1A1 gene expression in hepatocellular carcinoma cells.2012
- Author(s)
  幅野渉、三浦僚、丸本慎太郎、佐野祐子、寺島潤、蒲生俊恵、小澤正吾
- Organizer
  第27回日本薬物動態学会
- Place of Presentation
  千葉
- Data Source
  KAKENHI-PROJECT-24590451
[Presentation] エピジェネティックメカニズムによる薬物代謝酵素遺伝子発現調節2012
- Author(s)
  幅野渉
- Organizer
  日本薬学会東北支部総会・学術講演会
- Place of Presentation
  仙台
- Invited
- Data Source
  KAKENHI-PROJECT-24590451
[Presentation] Global DNA methylation analysis in Caco-2 and LS180 colon cancer cells2011
- Author(s)
  Habano W, Gamou T, Terashima J, Ozawa S.
- Organizer
  日本薬物動態学会第26回年会
- Place of Presentation
  広島
- Year and Date
  2011-11-16
- Data Source
  KAKENHI-PROJECT-21590402
[Presentation] Global DNA methylation analysis in Caco-2 and LS180 colon cancer cells2011
- Author(s)
  Habano W, Gamou T, Terashima J, Ozawa S
- Organizer
  日本薬物動態学会第26回年回
- Place of Presentation
  広島国際会議場(広島市)
- Year and Date
  2011-11-16
- Data Source
  KAKENHI-PROJECT-21590402
[Presentation] Involvement of promoter methylation in the regulation of Pregnane X receptor in colon cancer cells2010
- Author(s)
  Habano W, Gamou T, Terashima J, Sugai T, Ozawa
- Organizer
  日本薬物動態学会第25回年会
- Place of Presentation
  さいたま
- Year and Date
  2010-10-08
- Data Source
  KAKENHI-PROJECT-21590402
[Presentation] Involvement of promoter methylation in the regulation of Pregnane X receptor in colon cancer cells2010
- Author(s)
  Habano W, et al.
- Organizer
  日本薬物動態学会第25回年会
- Place of Presentation
  大宮ソニックシティ(さいたま市)
- Year and Date
  2010-10-08
- Data Source
  KAKENHI-PROJECT-21590402
[Presentation] 大腸癌細胞におけるPXR、VDR、 PRMT1遺伝子メチル化とCYP3A4発現調節における役割2009
- Author(s)
  幅野渉, 他
- Organizer
  日本薬物動態学会第24回年会
- Place of Presentation
  京都
- Year and Date
  2009-11-27
- Data Source
  KAKENHI-PROJECT-21590402
[Presentation] Methylation of PXR, VDR, and PRMT1 genes and their roles in the regulation of CYP3A4 expression in colon cancer cells2009
- Author(s)
  Habano W, Gamou T, Terashima J, Sugai T, Ozawa
- Organizer
  日本薬物動態学会第24回年会
- Place of Presentation
  京都
- Year and Date
  2009-11-27
- Data Source
  KAKENHI-PROJECT-21590402
[Presentation] DNAメチル化機構に着目した薬物代謝変動要因の探索
- Author(s)
  幅野渉、小澤正吾
- Organizer
  日本生化学会
- Place of Presentation
  京都
- Year and Date
  2014-10-15 – 2014-10-18
- Invited
- Data Source
  KAKENHI-PROJECT-24590451

1. SUGAI Tamotsu (20187628)

# of Collaborated Projects: 5 results

# of Collaborated Products: 24 results
2. NAKAI Keiko (40227723)

# of Collaborated Projects: 2 results

# of Collaborated Products: 2 results
3. NAKAI Kenji (90146035)

# of Collaborated Projects: 2 results

# of Collaborated Products: 2 results
4. IZUMOTO Hirishi (10265150)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
5. HITOMI Jiro (00218728)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. ISOGAI Sumio (60212966)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. KAMO Masaharu (40214564)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. SHOUJI Wataru (40250831)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. NAKAMURA Shin-ichi (20107816)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. HUKUHIRO Yoshiaki (20228927)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. YOSHIOKA Kunihiro (70210648)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
12. OBARA Wataru (90337155)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
13. KOBAYASHI Kouitiro (60277233)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
14. 上杉憲幸 (10291618)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
15. 小沢正吾 (20185581)

# of Collaborated Projects: 1 results

# of Collaborated Products: 9 results
16. 蒲生俊恵 (00464701)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
17. MCRIYA Shogo

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
18. 小岩弘之

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
19. SUZUKI Hiromu

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
20. 中村真一

# of Collaborated Projects: 0 results

# of Collaborated Products: 6 results
21. 山本英一郎

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

habano wataru 幅野 渉

Habano Wataru 幅野 渉

HABANO Wataru 幅野 渉

Research Projects

Research Products

Co-Researchers

Novel roles of DNA methylation in stress response mediated by nuclear receptor AhRPrincipal Investigator

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Development of epigenome sensor model mediated by nuclear receptor pathwayPrincipal Investigator

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Analysis of epigenetic alterations in tumor stromal cells and application in cancer diagnosis and treatment.Principal Investigator

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Analysis of epigenetic mechanisms on the regulation of drug metabolizing enzymes and its application to personalized drug therapyPrincipal Investigator

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Estimation of the role of genomic instability on drug response and its application for cancer chemotherapy.Principal Investigator

Principal Investigator

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Molecular analysis of single tumor gland in the gastrointestinal cancers

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Early screening of myocardial injury and lethal arrhythmia by 64-channel magnetocardiography and genetical predisposition

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Crypt FISH-腺管分離材料を用いたFISH法による染色体異常の解析-

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Research on molecular mechanisms of chromosomal instability in tumorsPrincipal Investigator

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Morphological and molecular biological analyses for the mechanism of vascular development in the embryogenesis

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Intestinal Spirochaetosis : Clinico-pathological study and identification of species by PCR

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A development of oligonucleotide based DNA array for CYP2C9 genotyping for individual therapy in patients with valve replacement receiving warfarin therapy

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ヒト腫瘍におけるミトコンドリア呼吸鎖複合体遺伝子の機能異常の検索と分子機構の解明Principal Investigator

Principal Investigator

habano wataru 幅野渉

Habano Wataru 幅野渉

HABANO Wataru 幅野渉