HABANO Wataru 幅野渉

Researcher Number	50332979
Other IDs
External Links
Affiliation *help	2007 – 2018 : Iwate Medical University, School of Pharmaceutical, Associate Professor 2002 – 2006 : 岩手医科大学, 医学部, 助手 2004 : Iwate Medical University, Assistant professor, 医学部, 講師 2003 : 岩手医大学, 医学部, 助手
Review Section/Research Field	Principal Investigator Human pathology / Human pathology Except Principal Investigator Human pathology / Medical systems / Circulatory organs internal medicine / General anatomy (including Histology/Embryology)
Keywords	Principal Investigator エピジェネティクス / 腺管分離法 / aneuploidy / DNAメチル化 / crypt isolation / 癌抑制遺伝子 / 消化器癌 / DNA methylation / ゲノム不安定化 / multiploid … More Except Principal Investigator Brachyspira pilosicoli / SNP / PCR / 大腸癌 / RT dispersion / Brachyspira aalborgi / 16s ribosomal DNA / Late potential / 遺伝子一塩基多計 / Bacterial colitis / 遺伝子発現 / 腺管分離 / 大腸生検 / allelic imbalance、 / NADH oxidase / 二光子顕微鏡 / 左側 / リンパ管 / 腎 / myocardial injury / lymphatic vessel / ワーファリン / DNAアレイ / 薬剤誘発QT延長 / OligoArrav / spectral analysis / ゼブラフィッシュ / magnetocardiograph / late potential / 人工弁 / 脳血管 / anti-coagulation therapy / zebrafish / Brachyspira aaloborgi / OligoArray法 / 転写因子 / 致死的不整脈 / CYP2C9 遺伝子多型 / 傷害心筋 / RTdispersion / 心磁計 / スペクトルム解析 / ラット / CD10 / 抗がん剤 / 遺伝子解析 / 単一腺管 / FISH / カリウムチャンネル / 血管新生 / 心筋傷害 / 一塩基遺伝子多型 / 人工弁置換術 / 脈管新生 / 高分解能心電計 / MUC5AC / Intestinal spirochetosis / 薬物療法 / p53 / CYP2C9 / 血管 / 血管伸長ガイダンス因子 / CYP2C9 genotype / イメージング / 右側 / Zoonotic infection / 血管内皮細胞 / intestinal spirochetosis / XII因子遺伝子 / organogenesis / 薬剤性QT延長 / 細菌性大腸炎 / rat / 個別化医療 / kidney / 遺伝子-塩基多計 / NADHoxidase / Intestinal spirochaetosis / warfarin / real-time PCR法 / 脳 / real-time PCR / drug-induced QT prolongation / signal-averaged vector-nroiected ECG / transcription factor / 胃癌 / AI / single nucleotide polymorphism / artificial valve replacement / Bracyspira aalborgi / CYP2C9P / vasculogenesis / 菌種同定 / ゼブラフイッシュ / 人畜共通感染症 / メチル化 / 腺管分離法 / angiogenesis / 血球分化 Less

癌間質のエピジェネティック変化に着目した癌悪性化機構の解明と診断・治療への応用Principal InvestigatorOngoing
- Principal Investigator
  
  幅野渉
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Human pathology
- Research Institution
  Iwate Medical University
Analysis of epigenetic mechanisms on the regulation of drug metabolizing enzymes and its application to personalized drug therapyPrincipal Investigator
- Principal Investigator
  
  HABANO WATARU
- Project Period (FY)
  2012 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Human pathology
- Research Institution
  Iwate Medical University
Estimation of the role of genomic instability on drug response and its application for cancer chemotherapy.Principal Investigator
- Principal Investigator
  
  HABANO Wataru
- Project Period (FY)
  2009 – 2011
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Human pathology
- Research Institution
  Iwate Medical University
Molecular analysis of single tumor gland in the gastrointestinal cancers
- Principal Investigator
  
  SUGAI Tamotsu
- Project Period (FY)
  2007 – 2008
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Human pathology
- Research Institution
  Iwate Medical University
Early screening of myocardial injury and lethal arrhythmia by 64-channel magnetocardiography and genetical predisposition
- Principal Investigator
  
  NAKAI Kenji
- Project Period (FY)
  2006 – 2007
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Medical systems
- Research Institution
  Iwate Medical University
Crypt FISH-腺管分離材料を用いたFISH法による染色体異常の解析-
- Principal Investigator
  
  上杉憲幸
- Project Period (FY)
  2005 – 2006
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  Human pathology
- Research Institution
  Iwate Medical University
Research on molecular mechanisms of chromosomal instability in tumorsPrincipal Investigator
- Principal Investigator
  
  HABANO Wataru
- Project Period (FY)
  2005 – 2006
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Human pathology
- Research Institution
  Iwate Medical University
Morphological and molecular biological analyses for the mechanism of vascular development in the embryogenesis
- Principal Investigator
  
  HITOMI Jiro
- Project Period (FY)
  2004 – 2006
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  General anatomy (including Histology/Embryology)
- Research Institution
  Iwate Medical University
Intestinal Spirochaetosis : Clinico-pathological study and identification of species by PCR
- Principal Investigator
  
  NAKAMURA Shin-ichi
- Project Period (FY)
  2004 – 2005
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Human pathology
- Research Institution
  Iwate Medical University
A development of oligonucleotide based DNA array for CYP2C9 genotyping for individual therapy in patients with valve replacement receiving warfarin therapy
- Principal Investigator
  
  NAKAI Kenji
- Project Period (FY)
  2003 – 2004
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Circulatory organs internal medicine
- Research Institution
  Iwate Medical University
ヒト腫瘍におけるミトコンドリア呼吸鎖複合体遺伝子の機能異常の検索と分子機構の解明Principal Investigator
- Principal Investigator
  
  幅野渉
- Project Period (FY)
  2002 – 2003
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Human pathology
- Research Institution
  Iwate Medical University

All 2017 2016 2015 2014 2013 2012 2011 2010 2009 2008 2007 2005 2004 Other

All Journal Article Presentation

[Journal Article] TET1 Depletion Induces Aberrant CpG Methylation in Colorectal Cancer Cells.2017
- Author(s)
  Eizuka M, Sugai T, Habano W, Uesugi N, Takahashi Y, Kawasaki K, Yamamoto E, Suzuki H, Matsumoto T.
- Journal Title
  
  PLoS One.
  
  Volume : -
- DOI
  10.1007/s00535-017-1317-2
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15K08383, KAKENHI-PROJECT-15K08973
[Journal Article] Analysis of molecular alterations in laterally spreading tumors of the colorectum.2017
- Author(s)
  Sugai T, Habano W, Takagi R, Yamano H, Eizuka M, Arakawa N, Takahashi Y, Yamamoto E, Kawasaki K, Yanai S, Ishida K, Suzuki H, Matsumoto T.
- Journal Title
  
  J Gastroenterol.
  
  Volume : 52 Pages : 715-723
- DOI
  10.1007/s00535-016-1269-y
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15K08383, KAKENHI-PROJECT-16K08655
[Journal Article] Molecular subtypes of colorectal cancers determined by PCR-based analysis.2017
- Author(s)
  Sugai T, Eizuka M, Takahashi Y, Fukagawa T, Habano W, Yamamoto E, Akasaka R, Otuska K, Matsumoto T, Suzuki H.
- Journal Title
  
  Cancer Sci
  
  Volume : 108 Pages : 427-434
- DOI
  10.1111/cas.13164
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15H04299, KAKENHI-PROJECT-15K08383
[Journal Article] Molecular differences in the microsatellite stable phenotype between left-sided and right-sided colorectal cancer.2016
- Author(s)
  Takahashi Y, Sugai T, Habano W, Ishida K, Eizuka M, Otsuka K, Sasaki A, Matsumoto T, Morikawa T, Unno M, Suzuki H.
- Journal Title
  
  Int J Cancer.
  
  Volume : 139 Pages : 2493-2501
- DOI
  10.1002/ijc.30377
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15H04299, KAKENHI-PROJECT-15K08383, KAKENHI-PROJECT-16K08655
[Journal Article] Combination of the histone deacetylase inhibitor depsipeptide and 5-fluorouracil upregulates major histocompatibility complex class II and p21 genes and activates caspase-3/7 in human colon cancer HCT-116 cells.2016
- Author(s)
  Okada K, Hakata S, Terashima J, Gamou T, Habano W, Ozawa S
- Journal Title
  
  Oncol Rep
  
  Volume : 36(4) Pages : 1875-1885
- DOI
  10.3892/or.2016.5008
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15K08383
[Journal Article] Clinicopathological and molecular alterations in early gastric cancers with the microsatellite instability-high phenotype.2016
- Author(s)
  Sugimoto R, Sugai T, Habano W, Endoh M, Eizuka M, Yamamoto E, Uesugi N, Ishida K, Kawasaki T, Matsumoto T, Suzuki H.
- Journal Title
  
  Int J Cancer 2016
  
  Volume : 1 Pages : 1689-97
- DOI
  10.1002/ijc.29916
- Peer Reviewed / Open Access / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-15K08973, KAKENHI-PROJECT-25460414, KAKENHI-PROJECT-25460463, KAKENHI-PROJECT-15H04299, KAKENHI-PROJECT-15K08383, KAKENHI-PROJECT-16K08654, KAKENHI-PROJECT-25460420
[Journal Article] Analysis of DNA methylation landscape reveals the roles of DNA methylation in the regulation of drug metabolizing enzymes.2015
- Author(s)
  Habano W, Kawamura K, Iizuka N, Terashima J, Sugai T, Ozawa S.
- Journal Title
  
  Clin Epigenetics.
  
  Volume : 7 Pages : 105-105
- DOI
  10.1186/s13148-015-0136-7
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15K08383, KAKENHI-PROJECT-25460420
[Journal Article] A CAR-responsive enhancer element locating approximately 31 kb upstream in the 5'-flanking region of rat cytochrome P450 (CYP) 3A1 gene2015
- Author(s)
  Gamou T, Habano W, Terashima J, Ozawa S.
- Journal Title
  
  Drug Metab Pharmacokinet.
  
  Volume : 30 Pages : 188-197
- DOI
  10.1016/j.dmpk.2014.12.008
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15K08383
[Journal Article] CYP1A1 and CYP1A2 expression levels are differentially regulated in three-dimensional spheroids of liver cancer cells compared to two-dimensional monolayer cultures2015
- Author(s)
  Terashima J, Goto S, Hattori H, Hoshi S, Ushirokawa M, Kudo K, Habano W, Ozawa S.
- Journal Title
  
  Drug Metab Pharmacokinet.
  
  Volume : 30 Pages : 434-440
- DOI
  10.1016/j.dmpk.2015.10.001
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15K08383
[Journal Article] An aryl hydrocarbon receptor induces VEGF expression through ATF4 under glucose deprivation in HepG22013
- Author(s)
  Terashima J, Tachikawa C, Kudo K, Habano W, Ozawa S
- Journal Title
  
  BMC Mol Biol. 2013 Dec 12;14:27
  
  Volume : 14 Pages : 27-27
- DOI
  10.1186/1471-2199-14-27
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24590451
[Journal Article] Involvement of promoter methylation in the regulation of Pregnane X receptor in colon cancer cells2011
- Author(s)
  Habano W, et al.
- Journal Title
  
  BMC Cancer
  
  Volume : (印刷中)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590402
[Journal Article] Altered expression of GADD45 genes during the development of chemical-mediated liver hypertrophy and liver tumor promotion in rats2011
- Author(s)
  Ozawa S, Gamou T, Habano W, Inoue K, Yoshida M, Nishikawa A, Nemoto K, Degawa M.
- Journal Title
  
  J Toxicol Sci
  
  Volume : 36(5) Pages : 613-23
- Data Source
  KAKENHI-PROJECT-21590402
[Journal Article] Altered expression of GADD45 genes during the development of chemical-mediated liver hypertrophy and liver tumor promotion in rats2011
- Author(s)
  Ozawa S, Gamou T, Habano W, et al
- Journal Title
  
  The Journal of Toxicological Sciences
  
  Volume : 36 Pages : 613-623
- DOI
  10.2131/jts.36.613
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590402
[Journal Article] A genetic association between s3-aderenoceptor and cholinergic receptor muscarinic 3 polymorphisms in irritable bowel syndrome2011
- Author(s)
  Onodera S, Chiba T, Sugai T, Habano W.
- Journal Title
  
  Hepatogastroenterology
  
  Volume : 58(110-111) Pages : 1474-8
- Data Source
  KAKENHI-PROJECT-21590402
[Journal Article] Expression of connexins and the effect of retinoic acid in oral keratinocytes2011
- Author(s)
  Hatakeyama S, Mikami T, Habano W, Takeda Y.
- Journal Title
  
  J Oral Sci
  
  Volume : 53(3) Pages : 327-32
- Data Source
  KAKENHI-PROJECT-21590402
[Journal Article] Super-induced gene expression of the N-methyl-D-aspartate receptor 2C subunit in chemical-induced hypertrophic liver in rats2011
- Author(s)
  Nemoto K, Tanaka T, Ikeda A, Ito S, Mizukami M, Hikida T, Gamou T, Habano W, Ozawa S, Inoue K, Yoshida M, Nishikawa A, Degawa M.
- Journal Title
  
  J Toxicol Sci
  
  Volume : 36(5) Pages : 507-14
- Data Source
  KAKENHI-PROJECT-21590402
[Journal Article] Super-induced gene expression of the N-methyl-D-aspartate receptor 2C subunit in chemical-induced hypertrophic liver in rats.2011
- Author(s)
  Nemoto K, Tanaka T, Ikeda A, Ito S, Mizukami M, Hikida T, Gamou T, Habano W, et al
- Journal Title
  
  The Journal of Toxicological Sciences
  
  Volume : 36 Pages : 507-514
- DOI
  10.2131/jts.36.507
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590402, KAKENHI-PROJECT-23590150
[Journal Article] Expression of connexins and the effect of retinoic acid in oral keratinocytes2011
- Author(s)
  Hatakeyama S, Mikami T, Habano W, Takeda Y
- Journal Title
  
  Journal of Oral Science
  
  Volume : 53 Pages : 327-332
- DOI
  10.2334/josnusd.53.327
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590402
[Journal Article] A genetic association between ss3-aderenoceptor and cholinergic receptor muscarinic 3 polymorphisms in irritable bowel syndrome2011
- Author(s)
  Onodera S, Chiba T, Sugai T, Habano W
- Journal Title
  
  Hepatogastroenterology
  
  Volume : 58 Pages : 1474-1478
- DOI
  10.5754/hge10153
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590402
[Journal Article] Induction of CYP1 family members under low-glucose conditions requires AhR expression and occurs through the nuclear translocation of AhR2011
- Author(s)
  Terashima J, Habano W, Gamou T, Ozawa S
- Journal Title
  
  Drug Metabolism and Pharmacokinetics
  
  Volume : 26 Pages : 577-583
- DOI
  10.2133/dmpk.DMPK-11-RG-054
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590402
[Journal Article] Induction of CYP1 family members under low-glucose conditions requires AhR expression and occurs through the nuclear translocation of AhR2011
- Author(s)
  Terashima J, Habano W, Gamou T, Ozawa S.
- Journal Title
  
  Drug Metab Pharmacokinet
  
  Volume : 26(6) Pages : 577-83
- Data Source
  KAKENHI-PROJECT-21590402
[Journal Article] Involvement of promoter methylation in the regulation of Pregnane X receptor in colon cancer cells2011
- Author(s)
  Habano W, Gamo T, Terashima J, Sugai T, Otsuka K, Wakabayashi G, Ozawa S.
- Journal Title
  
  BMC Cancer
  
  Volume : 11 Pages : 81-81
- Data Source
  KAKENHI-PROJECT-21590402
[Journal Article] Molecular analysis of gastric differentiated-type intramucosal and submucosal cancers.2010
- Author(s)
  Sugai T, Habano W, et al.
- Journal Title
  
  Int J Cancer (印刷中)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590402
[Journal Article] Molecular analysis of single isolated glands in gastric cancers and their surrounding gastric intestinal metaplastic mucosa.2010
- Author(s)
  Sugai T, Habano W, et al.
- Journal Title
  
  Oncol Rep 23(1)
  
  Pages : 25-33
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590402
[Journal Article] Molecular analysis of gastric differentiated-type intramucosal and submucosal cancers2010
- Author(s)
  Sugai T, Habano W, Endoh M, Konishi Y, Akasaka R, Toyota M, Yamano H, Koeda K, Wakabayashi G, Suzuki K.
- Journal Title
  
  Int J Cancer
  
  Volume : 127(11) Pages : 2500-9
- Data Source
  KAKENHI-PROJECT-21590402
[Journal Article] Association between tumor necrosis factor-alpha and Fc-gamma receptor polymorphisms with infliximab in Crohn's disease.2010
- Author(s)
  Tomita K, Chiba T, Sugai T, Habano W.
- Journal Title
  
  Hepatogastroenterology
  
  Volume : 57(99-100) Pages : 535-9
- Data Source
  KAKENHI-PROJECT-21590402
[Journal Article] Human intestinal spirochaetosis in northern Japan2010
- Author(s)
  Sato H, Nakamura S, Habano W, Wakabayashi G, Adachi Y.
- Journal Title
  
  J Med Microbiol
  
  Volume : 59(Pt 7) Pages : 791-6
- Data Source
  KAKENHI-PROJECT-21590402
[Journal Article] Molecular analysis of single isolated glands in gastric cancers and their surrounding gastric intestinal metaplastic mucosa2010
- Author(s)
  Sugai T, Habano W, Jiao YF, Toyota M, Suzuki H, Tsukahara M, Koizuka H, Akasaka R, Koeda K, Wakabayashi G, Suzuki K.
- Journal Title
  
  Oncol Rep
  
  Volume : 23(1) Pages : 25-33
- Data Source
  KAKENHI-PROJECT-21590402
[Journal Article] CYP1B1, but not CYP1A1, is downregulated by promoter methylation in colorectal cancers.2009
- Author(s)
  Habano W, et al.
- Journal Title
  
  Int J Oncol 34(4)
  
  Pages : 1085-1091
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590402
[Journal Article] Screening the single nucleotide polymorphisms in patients with internal carotid artery stenosis by oligonucleotide-based custom DNA array2009
- Author(s)
  Nakai K, Oyanagi M, Hitomi J, Ogasawara K, Inoue T, Kobayashi M, Nakai K, Suwabe A, Habano W, Baba T, Yoshida H, Ogawa A.
- Journal Title
  
  Bioinform Biol Insights
  
  Volume : 1 Pages : 63-9
- Data Source
  KAKENHI-PROJECT-21590402
[Journal Article] CYP1B1, but not CYP1A1, is downregulated by promoter methylation in colorectal cancers2009
- Author(s)
  Habano W, Gamo T, Sugai T, Otsuka K, Wakabayashi G, Ozawa S.
- Journal Title
  
  Int J Oncol
  
  Volume : 34(4) Pages : 1085-1
- Data Source
  KAKENHI-PROJECT-21590402
[Journal Article] 大腸癌における分子異常2008
- Author(s)
  菅井有, 幅野渉
- Journal Title
  
  胃と腸 43(13)
  
  Pages : 1965-1974
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590362
[Journal Article] Serrated Adenoma of the Colorectum Undergoes a Proliferation versus Differentiation Process2008
- Author(s)
  Yu-Fei Jiao, Shin-ichi Nakamura, Tamotsu Sugai, Noriyuki Yamada, Wataru Habano
- Journal Title
  
  New Conceptual Interpretation of Morphogenesis Oncology
  
  Pages : 127-134
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590362
[Journal Article] 大腸癌における分子異常.2008
- Author(s)
  菅井有, 幅野渉
- Journal Title
  
  胃と腸 43-13
  
  Pages : 1965-1974
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590362
[Journal Article] Novel approach for detecting global epigenetic alterations associated with tumor cell aneuploidy.2007
- Author(s)
  Habano W, Sugai T, et. al.
- Journal Title
  
  Int J Cancer 121
  
  Pages : 1487-1493
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590362
[Journal Article] 大腸側方発育型瘍の分子病理学的解析2007
- Author(s)
  高木亮, 菅井有, 山野泰穂, 幅野渉, 千葉俊美, 鈴木一幸
- Journal Title
  
  岩手医誌 59(5)
  
  Pages : 347-357
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590362
[Journal Article] Novel approach for detecting global epigenetic alterations associcated with tumor cell aneuploidy2007
- Author(s)
  Habano W, Sugai T, Jiao Y-F, Nakamura S.
- Journal Title
  
  Int J Cancer 121
  
  Pages : 1487-1493
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590362
[Journal Article] 子宮内膜癌における腺管分離法を用いた単一癌腺管の分子病理学的解析2007
- Author(s)
  永沢崇幸, 菅井有, 庄子忠宏, 幅野渉, 杉山徹
- Journal Title
  
  岩手医誌 59(5)
  
  Pages : 333-46
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590362
[Journal Article] Analysis of allelic imbalances at multiple cancer-related chromosomal loci and microsatellite instability within the same tumor using a single tumor gland from colorectal carcinomas.2005
- Author(s)
  Sugai T, Habano W, Nakamura S. et al.
- Journal Title
  
  Int J Cancer 114
  
  Pages : 337-345
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16590291
[Journal Article] Analysis genetic alterations associated with DNA diploidy, aneuploidy and multiploidy in gastric cancers.2005
- Author(s)
  Sugai T, Habano W, Nakamura S, et al.
- Journal Title
  
  Oncology 68
  
  Pages : 548-557
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16590291
[Journal Article] Analysis of SMAD4/DPC4 gene alterations in multiploid colorectal carcinomas.2005
- Author(s)
  Ando T, Habano W, et al.
- Journal Title
  
  J Gastroenterol 40
  
  Pages : 708-715
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16590291
[Journal Article] Ethnic Difference of Coronary Artery Disease-associated SNPs in Two Israeli Healthy Populations Using MALDI-TOF Mass Spectrometry.2004
- Author(s)
  Nakai K, Habano W, Nakai K, Fukushima N, Fujita T, Gurwitz D
- Journal Title
  
  Life Sciences 75
  
  Pages : 1003-1010
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15590768
[Journal Article] Three independent genetic profiles based on mucin expression in early differentiated-type gastric cancers - a new concept of genetic carcinogenesis of early differentiated-type adenocarcinomas.2004
- Author(s)
  Sugai T, Habano W, Nakamura S. et al.
- Journal Title
  
  Mod Pathol 17
  
  Pages : 1223-1234
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16590291
[Journal Article] Ethnic Difference of Coronary Artery Disease-associated SNPs in Two Israeli Healthy Populations Using MALDI-TOF Mass Spectrometry2004
- Author(s)
  Nakai K, Habano W, Nakai K, Fukushima N, Fujita T, Gurwitz D
- Journal Title
  
  Life Sciences 75
  
  Pages : 1003-1010
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15590768
[Journal Article] Analysis of Ki-ras gene mutations within the same tumor using a singlet tumor crypt in colorectal carcinomas.2004
- Author(s)
  Ishii M, Habano W, Nakamura S et al.
- Journal Title
  
  J Gastroenterol 39
  
  Pages : 544-549
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16590291
[Journal Article] Application of the crypt isolation technique to the flow cytometric analysis of DNA content in gastric carcinoma.2004
- Author(s)
  Jiao YF, Habano W, Nakamura S. et al.
- Journal Title
  
  Hum Pathol 35
  
  Pages : 587-593
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16590291
[Journal Article] Analysis microsatellite alterations in gastric carcinoma using the crypt isolation technique.2004
- Author(s)
  Jiao Yu, Habano W, Nakamura S, et al.
- Journal Title
  
  J Pathol 204
  
  Pages : 200-207
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16590291
[Journal Article] A novel approach for detecting global epigenetic alterations associated with tumor cell aneuploidy
- Author(s)
  Habano W. et al.
- Journal Title
  
  Int J Cancer (印刷中)
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17590313
[Journal Article] A novel approach for detecting global epigenetic alterations associated with tumor cell aneuploidy
- Author(s)
  Habano W. et al.
- Journal Title
  
  International Journal of Cancer (in press)
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17590313
[Journal Article] A novel approach for detecting global epigenetic alterations associated with tumor cell aneuploidy
- Author(s)
  Habano W. et al.
- Journal Title
  
  Int J Cancer (印刷中)
- Data Source
  KAKENHI-PROJECT-17590313
[Presentation] DNAメチル基転移酵素阻害剤併用によるヒト大腸がん細胞株のイリノテカン感受性増強とアポトーシス関連タンパクの発現変動2016
- Author(s)
  博多修子、寺島潤、幅野渉、小澤正吾
- Organizer
  第75回日本癌学会学術総会
- Place of Presentation
  横浜
- Year and Date
  2016-10-06
- Data Source
  KAKENHI-PROJECT-15K08383
[Presentation] AhRの肺がん細胞における遺伝子発現制御の解析2016
- Author(s)
  神馬瑤子、寺島潤、幅野渉、小澤正吾
- Organizer
  第75回日本癌学会学術総会
- Place of Presentation
  横浜
- Year and Date
  2016-10-06
- Data Source
  KAKENHI-PROJECT-15K08383
[Presentation] Analysis of DNA methylation landscape reveals the roles of DNA methylation in the regulation of drug metabolizing enzymes2015
- Author(s)
  幅野渉、寺島潤、小澤正吾
- Organizer
  日本薬物動態学会第30回年回
- Place of Presentation
  東京
- Year and Date
  2015-11-12
- Data Source
  KAKENHI-PROJECT-15K08383
[Presentation] オミクス情報を活用した薬物代謝変動要因の探索2014
- Author(s)
  幅野渉
- Organizer
  日本臨床検査医学会東北支部総会
- Place of Presentation
  盛岡
- Year and Date
  2014-08-09
- Invited
- Data Source
  KAKENHI-PROJECT-24590451
[Presentation] 薬物動態関連遺伝子のエピジェネティックな発現制御：プロモーターメチル化を中心に2013
- Author(s)
  幅野渉、小澤正吾
- Organizer
  日本薬物動態学会第28回年会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-24590451
[Presentation] Epigenetic regulation of the UGT1A1 gene expression in hepatocellular carcinoma cells.2012
- Author(s)
  幅野渉、三浦僚、丸本慎太郎、佐野祐子、寺島潤、蒲生俊恵、小澤正吾
- Organizer
  第27回日本薬物動態学会
- Place of Presentation
  千葉
- Data Source
  KAKENHI-PROJECT-24590451
[Presentation] エピジェネティックメカニズムによる薬物代謝酵素遺伝子発現調節2012
- Author(s)
  幅野渉
- Organizer
  日本薬学会東北支部総会・学術講演会
- Place of Presentation
  仙台
- Invited
- Data Source
  KAKENHI-PROJECT-24590451
[Presentation] Global DNA methylation analysis in Caco-2 and LS180 colon cancer cells2011
- Author(s)
  Habano W, Gamou T, Terashima J, Ozawa S.
- Organizer
  日本薬物動態学会第26回年会
- Place of Presentation
  広島
- Year and Date
  2011-11-16
- Data Source
  KAKENHI-PROJECT-21590402
[Presentation] Global DNA methylation analysis in Caco-2 and LS180 colon cancer cells2011
- Author(s)
  Habano W, Gamou T, Terashima J, Ozawa S
- Organizer
  日本薬物動態学会第26回年回
- Place of Presentation
  広島国際会議場(広島市)
- Year and Date
  2011-11-16
- Data Source
  KAKENHI-PROJECT-21590402
[Presentation] Involvement of promoter methylation in the regulation of Pregnane X receptor in colon cancer cells2010
- Author(s)
  Habano W, et al.
- Organizer
  日本薬物動態学会第25回年会
- Place of Presentation
  大宮ソニックシティ(さいたま市)
- Year and Date
  2010-10-08
- Data Source
  KAKENHI-PROJECT-21590402
[Presentation] Involvement of promoter methylation in the regulation of Pregnane X receptor in colon cancer cells2010
- Author(s)
  Habano W, Gamou T, Terashima J, Sugai T, Ozawa
- Organizer
  日本薬物動態学会第25回年会
- Place of Presentation
  さいたま
- Year and Date
  2010-10-08
- Data Source
  KAKENHI-PROJECT-21590402
[Presentation] 大腸癌細胞におけるPXR、VDR、 PRMT1遺伝子メチル化とCYP3A4発現調節における役割2009
- Author(s)
  幅野渉, 他
- Organizer
  日本薬物動態学会第24回年会
- Place of Presentation
  京都
- Year and Date
  2009-11-27
- Data Source
  KAKENHI-PROJECT-21590402
[Presentation] Methylation of PXR, VDR, and PRMT1 genes and their roles in the regulation of CYP3A4 expression in colon cancer cells2009
- Author(s)
  Habano W, Gamou T, Terashima J, Sugai T, Ozawa
- Organizer
  日本薬物動態学会第24回年会
- Place of Presentation
  京都
- Year and Date
  2009-11-27
- Data Source
  KAKENHI-PROJECT-21590402
[Presentation] DNAメチル化機構に着目した薬物代謝変動要因の探索
- Author(s)
  幅野渉、小澤正吾
- Organizer
  日本生化学会
- Place of Presentation
  京都
- Year and Date
  2014-10-15 – 2014-10-18
- Invited
- Data Source
  KAKENHI-PROJECT-24590451

1. SUGAI Tamotsu (20187628)

# of Collaborated Projects : 4results

# of Collaborated Products : 22results
2. NAKAI Keiko (40227723)

# of Collaborated Projects : 2results

# of Collaborated Products : 2results
3. NAKAI Kenji (90146035)

# of Collaborated Projects : 2results

# of Collaborated Products : 2results
4. IZUMOTO Hirishi (10265150)

# of Collaborated Projects : 1results

# of Collaborated Products : 0results
5. HITOMI Jiro (00218728)

# of Collaborated Projects : 1results

# of Collaborated Products : 0results
6. ISOGAI Sumio (60212966)

# of Collaborated Projects : 1results

# of Collaborated Products : 0results
7. KAMO Masaharu (40214564)

# of Collaborated Projects : 1results

# of Collaborated Products : 0results
8. SHOUJI Wataru (40250831)

# of Collaborated Projects : 1results

# of Collaborated Products : 0results
9. NAKAMURA Shin-ichi (20107816)

# of Collaborated Projects : 1results

# of Collaborated Products : 6results
10. HUKUHIRO Yoshiaki (20228927)

# of Collaborated Projects : 1results

# of Collaborated Products : 0results
11. YOSHIOKA Kunihiro (70210648)

# of Collaborated Projects : 1results

# of Collaborated Products : 0results
12. OBARA Wataru (90337155)

# of Collaborated Projects : 1results

# of Collaborated Products : 0results
13. KOBAYASHI Kouitiro (60277233)

# of Collaborated Projects : 1results

# of Collaborated Products : 0results
14. 上杉憲幸 (10291618)

# of Collaborated Projects : 1results

# of Collaborated Products : 0results
15. 小沢正吾 (20185581)

# of Collaborated Projects : 1results

# of Collaborated Products : 11results
16. 蒲生俊恵 (00464701)

# of Collaborated Projects : 1results

# of Collaborated Products : 0results
17. MCRIYA Shogo

# of Collaborated Projects : 1results

# of Collaborated Products : 0results
18. 小岩弘之

# of Collaborated Projects : 1results

# of Collaborated Products : 0results
19. 鈴木拓

# of Collaborated Projects : 0results

# of Collaborated Products : 3results
20. 石田和之

# of Collaborated Projects : 0results

# of Collaborated Products : 3results
21. 山本英一郎

# of Collaborated Projects : 0results

# of Collaborated Products : 3results
22. 根本清光

# of Collaborated Projects : 0results

# of Collaborated Products : 1results
23. 川崎朋範

# of Collaborated Projects : 0results

# of Collaborated Products : 1results

HABANO Wataru 幅野 渉

Research Projects

Research Products

Co-Researchers

癌間質のエピジェネティック変化に着目した癌悪性化機構の解明と診断・治療への応用Principal InvestigatorOngoing

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Analysis of epigenetic mechanisms on the regulation of drug metabolizing enzymes and its application to personalized drug therapyPrincipal Investigator

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Estimation of the role of genomic instability on drug response and its application for cancer chemotherapy.Principal Investigator

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Molecular analysis of single tumor gland in the gastrointestinal cancers

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Early screening of myocardial injury and lethal arrhythmia by 64-channel magnetocardiography and genetical predisposition

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Crypt FISH-腺管分離材料を用いたFISH法による染色体異常の解析-

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Research on molecular mechanisms of chromosomal instability in tumorsPrincipal Investigator

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Morphological and molecular biological analyses for the mechanism of vascular development in the embryogenesis

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Intestinal Spirochaetosis : Clinico-pathological study and identification of species by PCR

Principal Investigator

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A development of oligonucleotide based DNA array for CYP2C9 genotyping for individual therapy in patients with valve replacement receiving warfarin therapy

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ヒト腫瘍におけるミトコンドリア呼吸鎖複合体遺伝子の機能異常の検索と分子機構の解明Principal Investigator

Principal Investigator

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[Journal Article] TET1 Depletion Induces Aberrant CpG Methylation in Colorectal Cancer Cells.2017

Author(s)

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[Journal Article] Analysis of molecular alterations in laterally spreading tumors of the colorectum.2017

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HABANO Wataru 幅野渉