higuchi masaya 樋口雅也

… Alternative Names

HIGUCHI Masaya 樋口雅也

樋口雅也ヒグチマサヤ

Less

Researcher Number	50334678
Other IDs
Affiliation (Current)	2025: 金沢医科大学, 医学部, 教授
Affiliation (based on the past Project Information) *help	2016 – 2024: 金沢医科大学, 医学部, 教授 2015: 新潟大学, 医歯学系, 准教授 2009 – 2013: Niigata University, 医歯学系, 准教授 2008: Niigata University, 医歯学系, 講師 2006: 新潟大学, 医歯学系, 講師 2005: 新潟大学, 医歯学系, 助手 2002 – 2003: 新潟大学, 大学院・医歯学総合研究科, 助手
Review Section/Research Field	Principal Investigator Virology / Basic Section 52050:Embryonic medicine and pediatrics-related / Basic Section 54010:Hematology and medical oncology-related / Hematology / Virology Except Principal Investigator Basic Section 63020:Radiation influence-related / Basic Section 52050:Embryonic medicine and pediatrics-related / Basic Section 43010:Molecular biology-related / Experimental pathology
Keywords	Principal Investigator HTLV-1 / 造血幹細胞 / 脱ユビキチン化酵素 / USP10 / シグナル伝達 / ATL / 成人T細胞白血病 / 受容体 / パレコウイルスA3型 / パレコウイルス … More / 相同組換え修復 / PP6 / DNA-PKcs / 相同組み換え修復 / DNA修復 / 脱ユビキチン化 / 骨髄不全 / DNAダメージ応答 / アポトーシス / 造血肝細胞 / 白血病 / PDZドメイン / Tax / MAGI-1 / ROS / PDZ / 感染症 / ウイルス / 感染 / 細胞 / Tax1 / NFAT / Tax2 / HTLV-2 / NF-κB … More Except Principal Investigator 脱ユビキチン化 / DNA修復 / 核小体局在シグナル / 相同組換え修復 / DNA損傷修復 / 新生児感染症 / パレコウイルスA / cDNAライブラリー / レトロウイルスベクター / 細胞への侵入 / CRISPR/ Cas9 / 蛍光タンパク質発現組換えヒトパレコウイルス3型 / CRIPR/Cas9 / 蛍光タンパク質組換えヒトパレコウイルス3型 / PeV-A / ヒトパレコウイルス3型 / ウイルス受容体 / DNA 修復 / HR経路 / NHEJ経路 / 脱ユビキチン化酵素 / DNA損傷応答 / 造血幹細胞維持 / ゲノム安定性 / シグナル伝達 / 免疫学 / 炎症性腸疾患 / サイトカイン / 炎症 / NF-κB / IL-1 / TNFα / IL-1β / IL-6 / LPS / 炎症性サイトカイン / USP10 / マクロファージ Less

パレコウイルスA3型の新規受容体の同定と機能解析Principal Investigator
- Principal Investigator
  
  樋口雅也
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 52050:Embryonic medicine and pediatrics-related
- Research Institution
  Kanazawa Medical University
脱ユビキチン化酵素USP10が支配するDNA修復機構の解明
- Principal Investigator
  
  宇谷公一
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 63020:Radiation influence-related
- Research Institution
  Kanazawa Medical University
Studies on isolation and identification of human parechovirus 3 receptor gene and elucidation of the mechanism of severe disease
- Principal Investigator
  
  Watanabe Kanako
- Project Period (FY)
  2019 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 52050:Embryonic medicine and pediatrics-related
- Research Institution
  Niigata University
Deubiquitylase USP10 facilitates DNA damage response.
- Principal Investigator
  
  UTANI Koichi
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 43010:Molecular biology-related
- Research Institution
  Kanazawa Medical University
Mechanism of HSCs maintenace by deubiquitinating enzyme USP10Principal Investigator
- Principal Investigator
  
  HIGUCHI Masaya
- Project Period (FY)
  2018 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 54010:Hematology and medical oncology-related
- Research Institution
  Kanazawa Medical University
USP10 in LPS-stimulated macrophages acts on Regnase-1 to suppress inflammatory cytokines.
- Principal Investigator
  
  KAWAMURA Hiroki
- Project Period (FY)
  2017 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Experimental pathology
- Research Institution
  Niigata University of Health and Welfare
Mechanism of the maintenance of hematopoietic and leukemia stem cells by deubiquitinating enzyme USP10Principal Investigator
- Principal Investigator
  
  HIGUCHI Masaya
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Hematology
- Research Institution
  Kanazawa Medical University
  Niigata University
Mechanism of PDZ domain protein regulation for HTLV-1 tumorigenesisPrincipal Investigator
- Principal Investigator
  
  HIGUCHI Masaya
- Project Period (FY)
  2011 – 2013
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Virology
- Research Institution
  Niigata University
Elucidation of the mechanism of virological synapse mediated HTLV-1 infectionPrincipal Investigator
- Principal Investigator
  
  HIGUCHI Masaya
- Project Period (FY)
  2008 – 2010
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Virology
- Research Institution
  Niigata University
ヒトT細胞白血病ウイルス2型(HTLV-2)によるT細胞不死化メカニズムの解明Principal Investigator
- Principal Investigator
  
  樋口雅也
- Project Period (FY)
  2005 – 2006
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Virology
- Research Institution
  Niigata University
成人T細胞白血病の発症に関わる細胞遺伝子の同定Principal Investigator
- Principal Investigator
  
  樋口雅也
- Project Period (FY)
  2002 – 2003
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Virology
- Research Institution
  Niigata University

All 2023 2022 2021 2019 2018 2017 2016 2015 2013 2012 2011 2009 2008 Other

All Journal Article Presentation Other

[Journal Article] Myeloid-associated differentiation marker is an essential host factor for human parechovirus PeV-A3 entry2023
- Author(s)
  Watanabe Kanako、Oka Tomoichiro、Takagi Hirotaka、Anisimov Sergei、Yamashita Shun-ichi、Katsuragi Yoshinori、Takahashi Masahiko、Higuchi Masaya、Kanki Tomotake、Saitoh Akihiko、Fujii Masahiro
- Journal Title
  
  Nature Communications
  
  Volume: 14 Issue: 1 Pages: 1817-1817
- DOI
  10.1038/s41467-023-37399-8
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K15377, KAKENHI-PROJECT-21KK0166, KAKENHI-PROJECT-20K07757, KAKENHI-PROJECT-20K08320, KAKENHI-PLANNED-19H05712, KAKENHI-PROJECT-23K23878, KAKENHI-PROJECT-19K08294
[Journal Article] MAGI-1 expression is decreased in several types of human T-cell leukemia cell lines, including adult T-cell leukemia.2018
- Author(s)
  Kozakai T, Takahashi M, Higuchi M, Hara T, Saito K, Tanaka Y, Masuko M, Takizawa J, Sone H, Fujii M
- Journal Title
  
  International Journal of Hematology
  
  Volume: 107(3) Issue: 3 Pages: 337-344
- DOI
  10.1007/s12185-017-2359-1
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16K09868, KAKENHI-PROJECT-17K09918, KAKENHI-PROJECT-16K15502, KAKENHI-PROJECT-17K14989, KAKENHI-PROJECT-15H04704, KAKENHI-PROJECT-15K09469, KAKENHI-PROJECT-16K09822
[Journal Article] USP10 Is an Essential Deubiquitinase for Hematopoiesis and Inhibits Apoptosis of Long-Term Hematopoietic Stem Cells.2016
- Author(s)
  Higuchi M, Kawamura H, Matsuki H, Hara T, Takahashi M, Saito S, Saito K, Jiang S, Naito M, Kiyonari H, Fujii M.
- Journal Title
  
  Stem Cell Reports
  
  Volume: ７ Issue: 6 Pages: 1116-1129
- DOI
  10.1016/j.stemcr.2016.11.003
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-15H04704, KAKENHI-PROJECT-26461417, KAKENHI-PROJECT-15K21003, KAKENHI-PROJECT-15K09469, KAKENHI-PROJECT-16K15502
[Journal Article] HTLV-1 Tax oncoprotein stimulates ROS production and apoptosis in T cells by interacting with USP102013
- Author(s)
  Takahashi M, Higuchi M, Makokha GN, Matsuki H, Yoshita M, Tanaka Y, Fujii M
- Journal Title
  
  Blood
  
  Volume: 122 Pages: 715-725
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23590537
[Journal Article] Stress granules inhibit apoptosis by reducing ROS production2013
- Author(s)
  Takahashi M, Higuchi M, Matsuki H, Yoshita M, Ohsawa T, Oie M, Fujii M
- Journal Title
  
  Mol. Cell Biol
  
  Volume: 33 Pages: 815-829
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23590537
[Journal Article] Both G3BP1 and G3BP2 contribute to stress granule formation2013
- Author(s)
  Matsuki H, Takahashi M, Higuchi M, Makokha GN, Oie M, Fujii M
- Journal Title
  
  Genes Cells
  
  Volume: 18 Pages: 135-146
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23590537
[Journal Article] Human T-cell leukemia virus type 1 Tax protein interacts with and mislocalizes the PDZ domain protein MAGI-12013
- Author(s)
  Makokha GN, Takahashi M, Higuchi M, Saito S, Tanaka Y, Fujii M
- Journal Title
  
  Cancer Sci
  
  Volume: 104 Pages: 313-320
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23590537
[Journal Article] Human T cell leukemia virus type 2 (HTLV-2) Tax2 has a dominant activity over HTLV-1 Tax1 to immortalize human CD4(+) T cells2013
- Author(s)
  Imai M, Higuchi M, Kawamura H, Yoshita M, Takahashi M, Oie M, Matsuki H, Tanaka Y, Aoyagi Y, Fujii M
- Journal Title
  
  Virus Genes
  
  Volume: 46 Pages: 39-46
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23590537
[Journal Article] Activation of mTOR by human T-cell leukemia virus type 1 Tax is important for the transformation of mouse T cells to interleukin-2-independent growth2012
- Author(s)
  Yoshita M, Higuchi M, Takahashi M, Oie M, Tanaka Y, Fujii M
- Journal Title
  
  Cancer Science
  
  Volume: 103 Pages: 369-374
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23590537
[Journal Article] Knockdown of synapse-associated protein Dlg1 reduces syncytium formation induced by human T-cell leukemia virus type 1.2008
- Author(s)
  Yoshida S*, Higuchi M*, Shoji T, Yoshita M, Ishioka K, Takahashi M, Oie M, Tanaka Y, Uchiyama M, Fujii M.
- Journal Title
  
  Virus Genes(*equally contributed) 37
  
  Pages: 9-15
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590468
[Presentation] ヒトパレコウイルス３型はMYADMの第４細胞外領域に結合し感染する2023
- Author(s)
  渡邉香奈子　岡智一郎　高木弘隆　セルゲイアニシモフ　高橋雅彦　樋口雅也　藤井雅寛
- Organizer
  日本ウイルス学会
- Data Source
  KAKENHI-PROJECT-19K08294
[Presentation] 脱ユビキチン化酵素USP10によるDNA損傷修復経路の制御2022
- Author(s)
  宇谷公一、逆井良、岩淵邦芳、樋口雅也
- Organizer
  第81回日本癌学会学術集会
- Data Source
  KAKENHI-PROJECT-18K08340
[Presentation] ヒトパレコウイルスの受容体遺伝子の同定2021
- Author(s)
  渡邉香奈子　岡智一郎　高木弘隆　セルゲイアニシモフ　高橋雅彦　大桑孝子　樋口雅也　藤井雅寛
- Organizer
  第68回日本ウイルス学会
- Data Source
  KAKENHI-PROJECT-19K08294
[Presentation] 脱ユビキチン化酵素USP10によるDNA損傷応答制御2019
- Author(s)
  宇谷公一、逆井良、岩淵邦芳、樋口雅也
- Organizer
  第78回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-18K08340
[Presentation] 脱ユビキチン化酵素USP10によるDNA損傷応答制御2019
- Author(s)
  宇谷公一、逆井良、岩淵邦芳、樋口雅也
- Organizer
  日本癌学会
- Data Source
  KAKENHI-PROJECT-18K06070
[Presentation] リン酸化 SIRT1 は過剰な複製開始を防止することで染色体安定性へ寄与する2017
- Author(s)
  宇谷公一、清水典明、樋口雅也
- Organizer
  第７6回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-15K09469
[Presentation] 脱ユビキチン化酵素USP10は造血幹細胞の維持に必須である2016
- Author(s)
  樋口雅也、大桑孝子、姫田敏樹、川村宏樹、藤井雅寛
- Organizer
  第53回日本細菌学会中部支部会
- Place of Presentation
  日本歯科大学新潟生命歯学部（新潟県新潟市）
- Year and Date
  2016-10-28
- Data Source
  KAKENHI-PROJECT-15K09469
[Presentation] Ubiquitin specific protease 10 is essential for hematopoietic stem cell maintenance2015
- Author(s)
  Masaya Higuchi, Hiroki Kawamura, Toshifumi Hara, Masahiko Takahashi, Masahiro Fujii
- Organizer
  The 77th annual meeting of the Japanese society of hematology
- Place of Presentation
  Hotel Nikko Kanazawa (石川県金沢市）
- Year and Date
  2015-10-16
- Data Source
  KAKENHI-PROJECT-15K09469
[Presentation] HTLV-1 Tax はUSP10 と結合することによりT 細胞におけるROS 産生とアポトーシス誘導を活性化する2013
- Author(s)
  高橋雅彦、樋口雅也、藤井雅寛
- Organizer
  第72回日本癌学会学術総会
- Place of Presentation
  パシフィコ横浜
- Data Source
  KAKENHI-PROJECT-23590537
[Presentation] Stress granules inhibit apoptosis by reducing ROS production, but this phenomenon is nullified by HTLV-1 Tax2013
- Author(s)
  Masahiko Takahashi, Masaya Higuchi, Masahiro Fujii
- Organizer
  16th International Conference on Human Retrovirology HTLV and Related Viruses
- Place of Presentation
  Montreal, Canada
- Data Source
  KAKENHI-PROJECT-23590537
[Presentation] Naswa Makokha Grace PDZ蛋白MAGI-1の不活化はHTLV-1のTaxによるT細胞のトランスフォーメーションに関与する2013
- Author(s)
  藤井雅寛、高橋雅彦、樋口雅也
- Organizer
  第61回日本ウイルス学会学術集会
- Place of Presentation
  神戸国際会議場
- Data Source
  KAKENHI-PROJECT-23590537
[Presentation] tress granules inhibit apoptosis by reducing ROS production, but this phenomenon is nullified by HTLV-1 Tax2013
- Author(s)
  Takahashi M, Higuchi M, Fujii M
- Organizer
  16th International Conference on Human Retrovirology HTLV and Related Viruses
- Place of Presentation
  Montreal, Canada
- Data Source
  KAKENHI-PROJECT-23590537
[Presentation] HTLV-1 TaxはUSP10と結合することによりT細胞におけるROS産生とアポトーシス誘導を活性化する2013
- Author(s)
  高橋雅彦、樋口雅也、藤井雅寛
- Organizer
  第72回日本癌学会学術総会
- Place of Presentation
  パシフィコ横浜
- Data Source
  KAKENHI-PROJECT-23590537
[Presentation] PDZ蛋白MAGI-1の不活化はHTLV-1のTaxによるT細胞のトランスフォーメーションに関与する2013
- Author(s)
  藤井雅寛、高橋雅彦、樋口雅也、Naswa Makokha Grace
- Organizer
  第61回日本ウイルス学会学術集会
- Place of Presentation
  神戸国際会議場
- Data Source
  KAKENHI-PROJECT-23590537
[Presentation] HTLV-1のTax蛋白はUSP10を介してROS産生とROS依存性アポトーシスを誘導する2013
- Author(s)
  高橋雅彦、樋口雅也、藤井雅寛
- Organizer
  第61回日本ウイルス学会学術集会
- Place of Presentation
  神戸国際会議場
- Data Source
  KAKENHI-PROJECT-23590537
[Presentation] ストレス顆粒はROS産生を抑制することによりアポトーシスを阻害するが、これをHTLV-1のTax1は解除する2012
- Author(s)
  高橋雅彦,樋口雅也,藤井雅寛
- Organizer
  第71回日本癌学会学術総会
- Place of Presentation
  札幌市教育分化会館,北海道
- Data Source
  KAKENHI-PROJECT-23590537
[Presentation] HTLV-1 Tax1 represses the proapoptotic protein Bim, which is crucial for T-cell transformation2011
- Author(s)
  Higuchi M, Fujii M
- Organizer
  15th International Conference on Human Retrovirology : HTLV and Related Viruses
- Place of Presentation
  Leuven, Belgium
- Data Source
  KAKENHI-PROJECT-23590537
[Presentation] HTLV-1 Tax1とHTLV-2 Tax2の違いが病原性に寄与する2011
- Author(s)
  樋口雅也
- Organizer
  第70回日本癌学会学術総会
- Place of Presentation
  名古屋国際会議場（愛知県）
- Data Source
  KAKENHI-PROJECT-23590537
[Presentation] HTLV-1 Tax1 represses the proapoptotic protein Bim, which is crucial for T-cell transformation.2011
- Author(s)
  Masaya Higuchi
- Organizer
  15th International Conference on Human Retrovirology: HTLV and Related Viruses
- Place of Presentation
  Rector P.De Somer-Aula, Leuven, Belgium
- Data Source
  KAKENHI-PROJECT-23590537
[Presentation] HTLV-1 Tax1とHTLV-2 Tax2の違いが病原性に寄与する2011
- Author(s)
  樋口雅也,高橋雅彦,藤井雅寛
- Organizer
  第70回日本癌学会学術総会
- Place of Presentation
  名古屋
- Data Source
  KAKENHI-PROJECT-23590537
[Presentation] 新規HTLV-1 Tax1結合蛋白MPP7の同定とその生体内機能解析2009
- Author(s)
  樋口雅也、藤井雅寛
- Organizer
  第68回日本癌学会学術総会
- Place of Presentation
  パシフィコ横浜
- Year and Date
  2009-10-01
- Data Source
  KAKENHI-PROJECT-20590468
[]

1. UTANI Koichi (60583143)

# of Collaborated Projects: 2 results

# of Collaborated Products: 1 results
2. KAWAMURA Hiroki (20333495)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
3. Watanabe Kanako (80626094)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
4. 高橋雅彦 (80377192)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
5. 齋藤昭彦 (30531389)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. Hara Toshifumi

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
7. Saito Kousuke

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
8. アニシモフセルゲイ

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
9. 藤井雅寛

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
10. 増子正義

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

higuchi masaya 樋口 雅也

HIGUCHI Masaya 樋口 雅也

樋口 雅也 ヒグチ マサヤ

Research Projects

Research Products

Co-Researchers

パレコウイルスA3型の新規受容体の同定と機能解析Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

脱ユビキチン化酵素USP10が支配するDNA修復機構の解明

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Studies on isolation and identification of human parechovirus 3 receptor gene and elucidation of the mechanism of severe disease

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Deubiquitylase USP10 facilitates DNA damage response.

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Mechanism of HSCs maintenace by deubiquitinating enzyme USP10Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

USP10 in LPS-stimulated macrophages acts on Regnase-1 to suppress inflammatory cytokines.

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Mechanism of the maintenance of hematopoietic and leukemia stem cells by deubiquitinating enzyme USP10Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Mechanism of PDZ domain protein regulation for HTLV-1 tumorigenesisPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Elucidation of the mechanism of virological synapse mediated HTLV-1 infectionPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

ヒトT細胞白血病ウイルス2型(HTLV-2)によるT細胞不死化メカニズムの解明Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

成人T細胞白血病の発症に関わる細胞遺伝子の同定Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Myeloid-associated differentiation marker is an essential host factor for human parechovirus PeV-A3 entry2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] MAGI-1 expression is decreased in several types of human T-cell leukemia cell lines, including adult T-cell leukemia.2018

Author(s)

Journal Title

higuchi masaya 樋口雅也

HIGUCHI Masaya 樋口雅也

樋口雅也ヒグチマサヤ