Ishinaga Hajime 石永一

… Alternative Names

石永一イシナガハジメ

ISHINAGA Hajime 石永一

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Researcher Number	50335121
Affiliation (Current)	2025: 三重大学, 医学部附属病院, 講師
Affiliation (based on the past Project Information) *help	2022 – 2023: 三重大学, 医学部附属病院, 講師 2010 – 2016: 三重大学, 医学部附属病院, 講師 2011: 三重大学, 医学部付属病院, 講師 2007 – 2008: Mie University, Graduate achool of Medicine, Assistant
Review Section/Research Field	Principal Investigator Otorhinolaryngology / Basic Section 56050:Otorhinolaryngology-related Except Principal Investigator Otorhinolaryngology
Keywords	Principal Investigator MUC5AC / TGFβ / 繊維化 / miR-21 / 脂質ナノ粒子 / FaDu細胞 / ヌードマウス / 化学放射線療法 / 頭頸部扁平上皮癌 / miR-21阻害薬 … More / 作用機序 / p38 / クラリスロマイシン / ｐ３８ / MKP-1 / マクロライド / ＭＵＣ５ＡＣ / ＴＧＦα / Th2サイトカイン / IL-31 / 好酸球性副鼻腔炎 / EGFシグナリング / TGFα / eosinophilic sinusitis / TGFalpha / コラーゲン遺伝子 / 上気道リモデリング / NF-kB / 上気道慢性炎症疾患 / TGFbetal / MUC2遺伝子 / MUC 5 AC遺伝子 / TGFbeta1 / 粘液分泌 / リモデリング / ムチン遺伝子 … More Except Principal Investigator ムチン / 鼻科学 / remodeling / nasal mucosa / steroid / leukotriene / mucin / extracellular matrix / 卵白アルブミン / 上皮細胞 / 抗原刺激 / 杯細胞 / モルモット / 鼻アレルギー / リモデリング / 鼻粘膜 / ステロイド / ロイコトリエン / 細胞外マトリックス / NF-kB / エンテロトキシン / 粘液 / 副鼻腔炎 / 好酸球 / デキサメサゾン / マクロライド / MUC5AC / TNF-α / TGF-α / 好酸球性副鼻腔炎 / アレルギー性炎症 / ムチン遺伝子 / 制御性細胞 / IL-33 / 小児 / IgG4 / 制御性T細胞 / スギ花粉症 / 舌下免疫療法 Less

MiR-21 inhibition increases of the effects and suppresse the adverse effect of CRT in HNSCCPrincipal Investigator
- Principal Investigator
  
  石永一
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 56050:Otorhinolaryngology-related
- Research Institution
  Mie University
Investigation for the mechanism of macrolide and development for combination therapy with macrolidePrincipal Investigator
- Principal Investigator
  
  Ishinaga Hajime
- Project Period (FY)
  2014 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Otorhinolaryngology
- Research Institution
  Mie University
The effects of TGFalpha in intractable sinusitis and new treatmentPrincipal Investigator
- Principal Investigator
  
  ISHINAGA Hajime
- Project Period (FY)
  2011 – 2013
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Otorhinolaryngology
- Research Institution
  Mie University
Sublingual immunotherapy for pediatric cedar pollinosis and its mechanism by inducible regulatory T cells and IgG4.
- Principal Investigator
  
  YUTA Atsushi
- Project Period (FY)
  2010 – 2012
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Otorhinolaryngology
- Research Institution
  Mie University
Elucidation and control of mechanisms of mucus hypersecretion in the intractable upper airway diseases
- Principal Investigator
  
  TAKEUCHI Kazuhiko
- Project Period (FY)
  2010 – 2012
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Otorhinolaryngology
- Research Institution
  Mie University
The role of TGFbeta1 on remodeling for chronic upper airway epitheliumPrincipal Investigator
- Principal Investigator
  
  ISHINAGA Hajime
- Project Period (FY)
  2007 – 2008
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Otorhinolaryngology
- Research Institution
  Mie University
Characteristics and control of the upper airway remodeling
- Principal Investigator
  
  TAKEUCHI Kazuhiko
- Project Period (FY)
  2006 – 2007
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Otorhinolaryngology
- Research Institution
  Mie University

All 2023 2017 2016 2013 2012 2011 Other

All Journal Article Presentation

[Journal Article] Intravenous Delivery of miR-21 Inhibitor in Mice With Head and Neck Squamous Cell Carcinoma2023
- Author(s)
  Hajime Ishinaga,et al
- Journal Title
  
  Anticancer Research
  
  Volume: 43 Issue: 8 Pages: 3487-3491
- DOI
  10.21873/anticanres.16525
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K09683
[Journal Article] The role of miR-21 as a predictive biomarker and a potential target to improve the effects of chemoradiotherapy against head and neck squamous cell carcinoma2023
- Author(s)
  Hajime Ishinaga , et al
- Journal Title
  
  J Radiat Res
  
  Volume: 64 Issue: 4 Pages: 668-676
- DOI
  10.1093/jrr/rrad043
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K09683, KAKENHI-PROJECT-21K19640, KAKENHI-PROJECT-19KK0238, KAKENHI-PROJECT-23K24589
[Journal Article] Interleukin-33 induces mucin gene expression and goblet cell hyperplasia in human nasal epithelial cells.2017
- Author(s)
  Ishinaga H, et al
- Journal Title
  
  Cytokine
  
  Volume: 90 Pages: 60-65
- DOI
  10.1016/j.cyto.2016.10.010
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26462578, KAKENHI-PROJECT-15K09170
[Journal Article] Pathogenesis of eosinophilic chronic rhinosinusitis.2016
- Author(s)
  Shah SA, Ishinaga H, et al.
- Journal Title
  
  J Inflamm
  
  Volume: 13 Issue: 1 Pages: 1-9
- DOI
  10.1186/s12950-016-0121-8
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26462578
[Journal Article] Effects of Interleukin-31 onMUC5AC Gene Expression in Nasal2013
- Author(s)
  Shah SA, Ishinaga H, Hou B, Okano M, Takeuchi K.
- Journal Title
  
  Allergic Inflammation. Pharmacology
  
  Volume: 91 Pages: 158-164
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22591899
[Journal Article] Effects of Interleukin-31 on MUC5AC Gene Expression in Nasal Allergic Inflammation.2013
- Author(s)
  Shah SA, Ishinaga H, Hou Bo, Okano M, Takeuchi K.
- Journal Title
  
  Pharmacology
  
  Volume: 91 Issue: 3-4 Pages: 158-164
- DOI
  10.1159/000346609
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23592508
[Journal Article] Effects of interleukin-31 on MUC5AC gene expression in nasal allergic inflammation2013
- Author(s)
  Shah SA, Ishinaga H, Hou B, Okano M, Takeuchi K.
- Journal Title
  
  Pharmacology
  
  Volume: 91(3-4) Pages: 158-164
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23592508
[Journal Article] Effects of a novel nonantibiotic macrolide, EM900, on cytokine and mucin gene expression in a human airway epithelial cell line2011
- Author(s)
  Otsu K, Ishinaga H, Suzuki S, Sugawara A, Sunazuka T, Omura S, Jono H, Takeuchi K
- Journal Title
  
  Pharmacology
  
  Volume: 88(5-6) Pages: 327-332
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23592508
[Journal Article] Effect of clarithromycin and dexamethasone on mucus production in isografted rat trachea2011
- Author(s)
  Kitano M, Ishinaga H, et al.
- Journal Title
  
  Pharmacology
  
  Volume: 87 Pages: 56-62
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22591899
[Journal Article] The role of transforming growth factor-α on mucin overproduction in eosinophilic chronic rhinosinusitis2011
- Author(s)
  Ishinaga H, Shah SA, Sakaida H,Takeuchi K
- Journal Title
  
  Pharmacology
  
  Volume: 88 Issue: 5-6 Pages: 302-8
- DOI
  10.1159/000333794
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22591899, KAKENHI-PROJECT-23592508
[Journal Article] Effects of a novel nonantibiotic macrolide, EM900, on cytokine and mucin gene expression in a human airway epithelial cell line.2011
- Author(s)
  Otsu K, Ishinaga H, Suzuki S, Sugawara A, Sunazuka T, Omura S, Jono H, Takeuchi K.
- Journal Title
  
  Pharmacology
  
  Volume: 88 Issue: 5-6 Pages: 327-32
- DOI
  10.1159/000334339
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22591899, KAKENHI-PROJECT-22890175, KAKENHI-PROJECT-23790091
[Journal Article] Effects of clarithromycin and dexamethasone on mucus production in isografted rat trachea2011
- Author(s)
  Kitano M, Ishinaga H, Shimizu T, Takeuchi K, Majima Y
- Journal Title
  
  Pharmacology
  
  Volume: 87(1-2) Pages: 56-62
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23592508
[Journal Article] The role of transforming growth factor-αon mucin overproduction in eosinophilic chronic rhinosinusitis2011
- Author(s)
  Ishinaga H, Shah SA, Sakaida H, Takeuchi K
- Journal Title
  
  Pharmacology
  
  Volume: 88(5-6) Pages: 302-308
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23592508
[Journal Article] Effects of clarithromycin and dexamethasone on mucus production in isografted rat trachea2011
- Author(s)
  Kitano M, Ishinaga H, Shimizu T, Takeuchi K, Majima Y
- Journal Title
  
  Pharmacology.
  
  Volume: 87 Issue: 1-2 Pages: 56-62
- DOI
  10.1159/000322837
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22591899
[Presentation] マクロライド系抗菌薬によるムチン遺伝子発現抑制に対するMKP-1の役割(第二報）2016
- Author(s)
  石永　一
- Organizer
  マクロライド新作用研究会
- Place of Presentation
  飯田橋レインボービル(東京都・新宿区）
- Year and Date
  2016-07-23
- Data Source
  KAKENHI-PROJECT-26462578
[Presentation] マクロライド系抗菌薬によるムチン遺伝子発現抑制に対するMKP-1の役割(第二報）2016
- Author(s)
  石永　一
- Organizer
  マクロライド審査用研究会
- Place of Presentation
  飯田橋レインボービル（東京都・新宿区）
- Year and Date
  2016-07-29
- Data Source
  KAKENHI-PROJECT-26462578
[Presentation] ヒト気道上皮でのムチン遺伝子発現に対するIL-31 の影響Source2012
- Author(s)
  石永一,竹内万彦
- Organizer
  第29回日本耳鼻咽喉科免疫アレルギー学会
- Place of Presentation
  大津市
- Year and Date
  2012-02-17
- Data Source
  KAKENHI-PROJECT-22591899
[Presentation] ヒト気道上皮でのムチン遺伝子発現に対するIL-31の影響2012
- Author(s)
  石永一、竹内万彦
- Organizer
  第30回日本耳鼻咽喉科免疫アレルギー学会
- Place of Presentation
  大津、滋賀県
- Year and Date
  2012-02-17
- Data Source
  KAKENHI-PROJECT-22591899
[Presentation] Effects of EM900 on cytokine and mucin gene expression in a human airway epithelial cell line2011
- Author(s)
  Ishinaga H, Otsu K, Sakaida H, Takeuchi K
- Organizer
  30thinternational symposium on infection and allergy of the nose
- Place of Presentation
  To kyo
- Year and Date
  2011-09-21
- Data Source
  KAKENHI-PROJECT-22591899
[Presentation] マクロライド系抗菌薬によるムチン遺伝子発現抑制に対するMKP-1の役割
- Author(s)
  石永　一
- Organizer
  第1回マクロライド新作用研究会
- Place of Presentation
  飯田橋レインボービル
- Year and Date
  2014-07-18 – 2014-07-19
- Data Source
  KAKENHI-PROJECT-26462578
[Presentation] マクロライド系抗菌薬によるムチン遺伝子発現抑制に対するMKP-1の役割
- Author(s)
  石永　一
- Organizer
  日本耳鼻咽喉科免疫アレルギー学会
- Place of Presentation
  東武ホテルアバンテ東京
- Year and Date
  2015-02-26 – 2015-02-28
- Data Source
  KAKENHI-PROJECT-26462578

1. YUTA Atsushi (80293778)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
2. TAKEUCHI Kazuhiko (50206942)

# of Collaborated Projects: 2 results

# of Collaborated Products: 7 results
3. SAKAIDA Hiroshi (30378426)

# of Collaborated Projects: 2 results

# of Collaborated Products: 2 results
4. YAMANAKA Kei Ichi (70314135)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
5. MAJIMA Yuichi (60024791)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results

Ishinaga Hajime 石永 一

石永 一 イシナガ ハジメ

ISHINAGA Hajime 石永 一

Research Projects

Research Products

Co-Researchers

MiR-21 inhibition increases of the effects and suppresse the adverse effect of CRT in HNSCCPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Investigation for the mechanism of macrolide and development for combination therapy with macrolidePrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

The effects of TGFalpha in intractable sinusitis and new treatmentPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Sublingual immunotherapy for pediatric cedar pollinosis and its mechanism by inducible regulatory T cells and IgG4.

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Elucidation and control of mechanisms of mucus hypersecretion in the intractable upper airway diseases

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

The role of TGFbeta1 on remodeling for chronic upper airway epitheliumPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Characteristics and control of the upper airway remodeling

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Intravenous Delivery of miR-21 Inhibitor in Mice With Head and Neck Squamous Cell Carcinoma2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] The role of miR-21 as a predictive biomarker and a potential target to improve the effects of chemoradiotherapy against head and neck squamous cell carcinoma2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Interleukin-33 induces mucin gene expression and goblet cell hyperplasia in human nasal epithelial cells.2017

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Pathogenesis of eosinophilic chronic rhinosinusitis.2016

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Effects of Interleukin-31 onMUC5AC Gene Expression in Nasal2013

Author(s)

Journal Title

Data Source

[Journal Article] Effects of Interleukin-31 on MUC5AC Gene Expression in Nasal Allergic Inflammation.2013

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Effects of interleukin-31 on MUC5AC gene expression in nasal allergic inflammation2013

Author(s)

Journal Title

Ishinaga Hajime 石永一

石永一イシナガハジメ

ISHINAGA Hajime 石永一