YOKOYA MASASHI 横屋正志

… Alternative Names

横屋正志ヨコヤマサシ

YOKOYA Masashi 横屋正志

Less

Researcher Number	50338539
Other IDs
Affiliation (Current)	2025: 明治薬科大学, 薬学部, 准教授
Affiliation (based on the past Project Information) *help	2020 – 2022: 明治薬科大学, 薬学部, 准教授 2011 – 2013: 明治薬科大学, 薬学部, 助教 2002 – 2003: 昭和大学, 薬学部, 助手
Review Section/Research Field	Principal Investigator Basic Section 47010:Pharmaceutical chemistry and drug development sciences-related Except Principal Investigator Chemical pharmacy / Chemical pharmacy
Keywords	Principal Investigator 抗アポトーシス性タンパク質 / Akt-mTOR / イソキノリン / MCL-1 / がん幹細胞 / Mcl-1 / アポトーシス / イソキノリンアルカロイド / 抗がん剤 / 海洋天然物 … More Except Principal Investigator … More semicarbazone / amino group / active oxygen / nitrogen oxide / aza compounds / ジスルフィド結合 / アミド結合 / アミン類 / ジスルフィド / 活性酸素 / セミカルバゾン / アミノ基 / 活性酵素 / 窒素酸化物 / 一酸化窒素 / 含窒素化合物 / タイ王国 / 国際情報交流 / フィリピン / タイ / 構造決定 / 国際情報交換 / 構造活性相関 / 合成 / 制癌剤 / レニエラマイシン / エクチナサイジン / 全合成 / 構造解析 / 国際共同研究 / イソキノリン / 抗腫瘍活性 / 海洋天然物 Less

Development of new anti-cancer drug with anti-apoptotic protein MCL-1 selective inhibitory activityPrincipal Investigator
- Principal Investigator
  
  YOKOYA MASASHI
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 47010:Pharmaceutical chemistry and drug development sciences-related
- Research Institution
  Meiji Pharmaceutical University
Development for medicinal chemistry on antitumor isoquinoline marine natural products as lead compound
- Principal Investigator
  
  SAITO NAOKI
- Project Period (FY)
  2011 – 2013
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Chemical pharmacy
- Research Institution
  Meiji Pharmaceutical University
Study of the chemical reactivity of nitric oxide and other related biological redicals
- Principal Investigator
  
  OHSAWA Akio
- Project Period (FY)
  2002 – 2003
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Chemical pharmacy
- Research Institution
  Showa University

All 2023 2022 2020 2014 2013 2012 2011

All Journal Article Presentation

[Journal Article] Transformation of Renieramycin M into Renieramycins T and S by Intramolecular Photoredox Reaction of 7-Methoxy-6-methyl-1,2,3,4-tetrahydroisoquinoline-5,8-dione Derivatives2023
- Author(s)
  Yokoya Masashi、Yamazaki-Nakai Miku、Nakai Keiyo、Sirimangkalakitti Natchanun、Chamni Supakarn、Suwanborirux Khanit、Saito Naoki
- Journal Title
  
  Journal of Natural Products
  
  Volume: 86 Issue: 1 Pages: 222-231
- DOI
  10.1021/acs.jnatprod.2c00974
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20K06977
[Journal Article] Novel Synthetic Derivative of Renieramycin T Right-Half Analog Induces Apoptosis and Inhibits Cancer Stem Cells via Targeting the Akt Signal in Lung Cancer Cells2023
- Author(s)
  Petsri Korrakod、Yokoya Masashi、Racha Satapat、Thongsom Sunisa、Thepthanee Chorpaka、Innets Bhurichaya、Ei Zin Zin、Hotta Daiki、Zou Hongbin、Chanvorachote Pithi
- Journal Title
  
  International Journal of Molecular Sciences
  
  Volume: 24 Issue: 6 Pages: 5345-5345
- DOI
  10.3390/ijms24065345
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K06977
[Journal Article] Akt/mTOR Targeting Activity of Resveratrol Derivatives in Non-Small Lung Cancer2022
- Author(s)
  Innets Bhurichaya、Thongsom Sunisa、Petsri Korrakod、Racha Satapat、Yokoya Masashi、Moriue Sohsuke、Chaotham Chatchai、Chanvorachote Pithi
- Journal Title
  
  Molecules
  
  Volume: 27 Issue: 23 Pages: 8268-8268
- DOI
  10.3390/molecules27238268
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K06977
[Journal Article] LIPASE-CATALYZED SITE-SELECTIVE DEACETYLATION OF 2METHOXY-3-METHYLNAPHTHALENE-1,4-DIOL DIACETATE FOR CONSTRUCTION OF CHARACTERISTIC SUBSTITUTED 1,2,3,4TETRAHYDROISOQUINOLINE DERIVATIVE OF ECTEINASCIDIN MARINE NATURAL PRODUCT2022
- Author(s)
  Masashi Yokoya, Ryo Sato, Naoki Saito
- Journal Title
  
  Heterocycles
  
  Volume: 105 Issue: 1 Pages: 511-511
- DOI
  10.3987/com-21-s(r)1
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20K06977
[Journal Article] Structure-activity relationships and molecular docking analysis of Mcl-1 targeting renieramycin T analogues in patient-derived lung cancer cells2020
- Author(s)
  Petsri K., Yokoya M., Tungsukruthai S., Rungrotmongkol T., Nutho B., Vinayanuwattikun C., Saito N., Matsubara T., Sato R, Chanvorachote P.
- Journal Title
  
  Cancers
  
  Volume: 12 (4) Issue: 4 Pages: 875-875
- DOI
  10.3390/cancers12040875
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K06561, KAKENHI-PROJECT-20K06977
[Journal Article] Isolation, structure characterization, and synthesis of stabilized 1,2,3,4-tetrahydroisoquinline marine natural product from pretreated Thai tunicate Ecteinascidia thrstoni with potassium cyanide2014
- Author(s)
  Kimura S., Pangkruang W., Yokoya M., Honda A., Puthongking P., Suwanborirux K., Saito N.
- Journal Title
  
  Heterocycles
  
  Volume: 88 (1) Issue: 1 Pages: 363-375
- DOI
  10.3987/com-13-s(s)32
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23590019
[Journal Article] Preparation of Tricyclic Lactam Model Compounds of Renieramycin and Saframycin Anticancer natural Products from Common Intermediate2013
- Author(s)
  Keiyo Nakai, Masashi Yokoya, Naoki Saito
- Journal Title
  
  Chem. Pharm. Bull
  
  Volume: 61 Pages: 853-869
- NAID
  130003360817
- URL
  https://www.jstage.jst.go.jp/article/cpb/61/8/61_c13-00361/_pdf
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23590019
[Journal Article] Preparation of tricyclic lactam model compounds of renieramycin and saframycin anticancer natural products from common intermediate2013
- Author(s)
  Nakai K., Yokoya M., Saito N.
- Journal Title
  
  Chem. Pharm. Bull.
  
  Volume: 61(8) Pages: 853-869
- NAID
  130003360817
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23590019
[Journal Article] Chemistry of Renieramycins. Part 12. An Improved Total Synthesis of (±)-Renieramycin G2012
- Author(s)
  Masashi Yokoya, Kimiko Shinada-Fujino, Saiko Masahiro Mimura, Yoshida, Hiroki Takada, Naoki Saito
- Journal Title
  
  Tetrahedron
  
  Volume: 68 Issue: 22 Pages: 4166-4181
- DOI
  10.1016/j.tet.2012.03.105
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23590019
[Journal Article]2012
- Author(s)
  Mari Tatsukawa, Louvy Lynn C.Punzalan,Hilbert D. S. Magpantay, Irene M. Villasenñr, Gisela P. Concepcion, Khanit Suwanborirux, Masashi Yokoya, Naoki Saito
- Journal Title
  
  Tetrahedron
  
  Volume: 68 Issue: 36 Pages: 7422-7428
- DOI
  10.1016/j.tet.2012.06.067
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23590019
[Journal Article] Chemistry of renieramycins. Part 13. Isolation and structure of stabilized renieramycin type derivatives, renieramycins W-Y, from Philippine blue sponge Xestospongia sp., pretreated with potassium cyanide2012
- Author(s)
  Tatsukawa M., Punzalan LL., Magpantay H. D. S., Villasenor I. M., Concepcion G. P., Suwanborirux K., Yokoya M., Saito N.
- Journal Title
  
  Tetrahedron
  
  Volume: 68 Pages: 7422-7428
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23590019
[Journal Article] Chemistry of renieramycins. Part 12. An inproved total synthesis of (;/-)-renieramycin G2012
- Author(s)
  Yokoya M., Shinada-Fujino K., Yoshida S., Mimura M., Takada H., Saito N.
- Journal Title
  
  Tetrahedron
  
  Volume: 68 Pages: 4166-4181
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23590019
[Journal Article] Synthesis of Renieramycins. Construction of the Core Ring System of Cribrostatin 4 Trough Modified Pictet-Spengler Cyclization of 3,6-Bisarylpiperazine-2,5-Dione with Diethoxyethyl Benzoate2011
- Author(s)
  Masashi Yokoya, Hiroshi Ito, Naoki Saito
- Journal Title
  
  Chem. Pharm. Bull
  
  Volume: 59 Pages: 787-792
- URL
  https://www.jstage.jst.go.jp/article/cpb/59/6/59_6_787/_pdf
- Data Source
  KAKENHI-PROJECT-23590019
[Journal Article] Synthesis of renieramycins: construction of2011
- Author(s)
  Yokoya M., Ito H., Saito N.
- Journal Title
  
  Chem. Pharm. Bull.
  
  Volume: 59 Pages: 787-792
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23590019
[Journal Article] Chemistry of Renieramycins. Part 9. Stereocontrolled Total Synthesis of (±)-Renieramycin G2011
- Author(s)
  Masashi Yokoya, Kimiko Shinada-Fujino, Naoki Saito
- Journal Title
  
  Tetrahedron Lett
  
  Volume: 52 Pages: 2446-2449
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23590019
[Journal Article] Chemistry of renieramycins. Part 9: Stereo-2011
- Author(s)
  Yokoya M., Shinada-Fujino K., Saito N.
- Journal Title
  
  Tetrahedron Letters
  
  Volume: 52 Pages: 2446-2449
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23590019
[Journal Article] Chemistry of Renieramycins. Part 11. Total Synthesis of (±)-Cribrostatin 42011
- Author(s)
  Masashi Yokoya, Hiroshi Ito, Naoki Saito
- Journal Title
  
  Tetrahedron
  
  Volume: 67 Issue: 47 Pages: 9185-9192
- DOI
  10.1016/j.tet.2011.09.076
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23590019
[Presentation] 抗腫瘍活性レニエラマイシン海洋天然物を基盤としたMCL-1標的薬の開発2022
- Author(s)
  堀田　大貴、Chanvorachote　Pithia、木村　真也、山中　正道、齋藤　直樹、横屋　正志
- Organizer
  日本薬学会第142年会
- Data Source
  KAKENHI-PROJECT-20K06977
[Presentation] 抗腫瘍活性レニエラマイシン海洋天然物を基盤としたMCL-1標的薬の開発2022
- Author(s)
  堀田大貴、Chanvorachote Pithi、木村真也、山中正道、齋藤直樹、横屋正志
- Organizer
  日本薬学会年会
- Data Source
  KAKENHI-PROJECT-20K06977
[Presentation] レニエラマイシンMの右半部モデル化合物の合成と生物活性評価2014
- Author(s)
  中井啓陽、久保佳司、横屋正志、齋藤直樹
- Organizer
  日本薬学会第134年会
- Place of Presentation
  熊本大学
- Data Source
  KAKENHI-PROJECT-23590019
[Presentation] サフラマイシンAの合成（その２）2014
- Author(s)
  河合慎太郎、東雅之、木村真也、横屋正志、齋藤直樹
- Organizer
  日本薬学会第134年会
- Place of Presentation
  熊本大学
- Data Source
  KAKENHI-PROJECT-23590019
[Presentation] 海洋天然物クリブロスタチン4の基本骨格形成反応の機構会計に向けた化学的研究2014
- Author(s)
  小林恵一郎、伊東裕史、横屋正志、齋藤直樹
- Organizer
  日本薬学会第134年会
- Place of Presentation
  熊本大学
- Data Source
  KAKENHI-PROJECT-23590019
[Presentation] レニエラマイシン右半部モデル化合物の合成と生物活性評価2014
- Author(s)
  中井啓陽、久保圭司、横屋正志、齋藤直樹
- Organizer
  日本薬学会第134 年会
- Place of Presentation
  熊本
- Year and Date
  2014-03-28
- Data Source
  KAKENHI-PROJECT-23590019
[Presentation] 抗腫瘍活性海洋天然物レニエラマイシンMの全合成2013
- Author(s)
  高田裕樹、三村政博、横屋正志、齋藤直樹
- Organizer
  日本薬学会第133年会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-23590019
[Presentation] 抗腫瘍活性天然物レニエラマイシンM の全合成2013
- Author(s)
  高田裕樹、三村政博、横屋正志、齋藤直樹
- Organizer
  日本薬学会第133 年会
- Place of Presentation
  横浜
- Year and Date
  2013-03-29
- Data Source
  KAKENHI-PROJECT-23590019
[Presentation] タイの群体ホヤ由来1,2,3,4-テトラヒドロイソキノリン海洋天然物の単利・構造決定および合成2013
- Author(s)
  木村真也、Waree Pangkruang, 横屋正志、本田遍、Ploenthip Puthongking, Khanit Suwanborirux, 齋藤直樹
- Organizer
  第57回日本薬学会関東支部大会
- Place of Presentation
  帝京大学薬学部（東京）
- Data Source
  KAKENHI-PROJECT-23590019
[Presentation] 1,2,3,4-テトラヒドロイソキノリンのアセチル化に対する挙動2013
- Author(s)
  中井啓陽、木村真也、横屋正志、齋藤直樹
- Organizer
  日本薬学会第133年会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-23590019
[Presentation] サフラマイシンAの全合成アプローチ2013
- Author(s)
  河合慎太郎、東雅之、木村真也、横屋正志、齋藤直樹
- Organizer
  日本薬学会第133年会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-23590019
[Presentation] 抗腫瘍活性テトラヒドロイソキノリン天然物の合成ー共通中間体から左半部モデル化合物の合成2013
- Author(s)
  中井啓陽、久保佳司、中山梨乃、横屋正志、齋藤直樹
- Organizer
  第39回反応と合成の進歩シンポジウム
- Place of Presentation
  九州大学（博多）
- Data Source
  KAKENHI-PROJECT-23590019
[Presentation] 抗腫瘍活性テトラヒドロイソキノリン天然物の合成―共通中間体から左半部モデル化合物の合成2013
- Author(s)
  中井啓陽、久保圭司、中山梨乃、横屋正志、齋藤直樹
- Organizer
  第39回反応と合成の進歩シンポジウム
- Place of Presentation
  福岡
- Year and Date
  2013-11-05
- Data Source
  KAKENHI-PROJECT-23590019
[Presentation] 青色海綿由来イソキノリン海洋天然物の全合成研究2012
- Author(s)
  横屋正志、伊藤裕史、齋藤直樹
- Organizer
  第37回反応と合成の進歩シンポジウム
- Place of Presentation
  徳島
- Year and Date
  2012-11-07
- Data Source
  KAKENHI-PROJECT-23590019
[Presentation] Chemistry of renieramycin antitumor marine natural products. An improved total synthesis of (+/-)-renieramycin G2012
- Author(s)
  Saito N., Shinada-Fujino K., Yokoya M.
- Organizer
  13th Tetrahedron Symposium
- Place of Presentation
  アムステルダム
- Data Source
  KAKENHI-PROJECT-23590019
[Presentation] レニエラマイシンGの改良合成：工程数の短縮2012
- Author(s)
  高田裕樹、横屋正志、三村正博、齋藤直樹
- Organizer
  第56回日本薬学会関東支部大会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-23590019
[Presentation] Chemistry of Renieramycin Antitumor Marine Natural Products. An Improved Total Synthesis of (±)-Renieramycin G2012
- Author(s)
  Naoki Saito, Kimiko Shinada-Fujuno, Masashi Yokoya
- Organizer
  15^<th> tetrahedron Symposium
- Place of Presentation
  Amsterdam (the Netherlands)
- Year and Date
  2012-06-27
- Data Source
  KAKENHI-PROJECT-23590019
[Presentation] フィルピンに生息する青色海綿が生産する新規レニエラマイシン海洋天然物の構造2012
- Author(s)
  辰川真理、平出裕美、横屋正志、Louvy L. C. Punzalan, Hirbert D. S. Magpantay, Gisela P. Concepcion, 齋藤直樹
- Organizer
  第56回日本薬学会関東支部大会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-23590019

1. SAITO NAOKI (80142545)

# of Collaborated Projects: 1 results

# of Collaborated Products: 29 results
2. OHSAWA Akio (00102369)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
3. MIYAZAKI Michiko (00266165)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
4. NAGATA Kazuhiro (20208010)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
5. ITOH Takashi (40159885)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results

YOKOYA MASASHI 横屋 正志

横屋 正志 ヨコヤ マサシ

YOKOYA Masashi 横屋 正志

Research Projects

Research Products

Co-Researchers

Development of new anti-cancer drug with anti-apoptotic protein MCL-1 selective inhibitory activityPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Development for medicinal chemistry on antitumor isoquinoline marine natural products as lead compound

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Study of the chemical reactivity of nitric oxide and other related biological redicals

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Transformation of Renieramycin M into Renieramycins T and S by Intramolecular Photoredox Reaction of 7-Methoxy-6-methyl-1,2,3,4-tetrahydroisoquinoline-5,8-dione Derivatives2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Novel Synthetic Derivative of Renieramycin T Right-Half Analog Induces Apoptosis and Inhibits Cancer Stem Cells via Targeting the Akt Signal in Lung Cancer Cells2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Akt/mTOR Targeting Activity of Resveratrol Derivatives in Non-Small Lung Cancer2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] LIPASE-CATALYZED SITE-SELECTIVE DEACETYLATION OF 2METHOXY-3-METHYLNAPHTHALENE-1,4-DIOL DIACETATE FOR CONSTRUCTION OF CHARACTERISTIC SUBSTITUTED 1,2,3,4TETRAHYDROISOQUINOLINE DERIVATIVE OF ECTEINASCIDIN MARINE NATURAL PRODUCT2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Structure-activity relationships and molecular docking analysis of Mcl-1 targeting renieramycin T analogues in patient-derived lung cancer cells2020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Isolation, structure characterization, and synthesis of stabilized 1,2,3,4-tetrahydroisoquinline marine natural product from pretreated Thai tunicate Ecteinascidia thrstoni with potassium cyanide2014

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Preparation of Tricyclic Lactam Model Compounds of Renieramycin and Saframycin Anticancer natural Products from Common Intermediate2013

Author(s)

Journal Title

NAID

URL

Data Source

[Journal Article] Preparation of tricyclic lactam model compounds of renieramycin and saframycin anticancer natural products from common intermediate2013

Author(s)

Journal Title

NAID

Data Source

[Journal Article] Chemistry of Renieramycins. Part 12. An Improved Total Synthesis of (±)-Renieramycin G2012

Author(s)

Journal Title

DOI

Data Source

[Journal Article]2012

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Chemistry of renieramycins. Part 13. Isolation and structure of stabilized renieramycin type derivatives, renieramycins W-Y, from Philippine blue sponge Xestospongia sp., pretreated with potassium cyanide2012

Author(s)

Journal Title

Data Source

[Journal Article] Chemistry of renieramycins. Part 12. An inproved total synthesis of (;/-)-renieramycin G2012

YOKOYA MASASHI 横屋正志

横屋正志ヨコヤマサシ

YOKOYA Masashi 横屋正志