Iwawaki Takao 岩脇隆夫

… Alternative Names

Researcher Number	50342754
Other IDs
Affiliation (Current)	2022: 金沢医科大学, 総合医学研究所, 教授
Affiliation (based on the past Project Information) *help	2018 – 2021: 金沢医科大学, 総合医学研究所, 教授 2016: 金沢医科大学, 総合医学研究所, 教授 2015: 群馬大学, 医学(系)研究科(研究院), 講師 2011 – 2014: 群馬大学, 先端科学研究指導者育成ユニット, 講師 2010: The Institute of Physical and Chemical Research, 中野生体膜研究室, 客員主管研究員 … More
Review Section/Research Field	Principal Investigator General physiology / Biological Sciences / Neurochemistry/Neuropharmacology / Environmental physiology(including physical medicine and nutritional physiology) / Basic Section 42040:Laboratory animal science-related / Basic Section 59020:Sports sciences-related
Keywords	Principal Investigator 小胞体ストレス / タンパク質品質管理 / IRE1 / 炎症 / GFP / XBP1 / トランスジェニックマウス / 血管新生 / 胎盤 / 膵臓 … More

細胞ストレスと炎症の発展的研究から迫る「疲労」メカニズムの分子細胞生物学的な解明Principal Investigator
- Principal Investigator
  
  岩脇隆夫
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 59020:Sports sciences-related
- Research Institution
  Kanazawa Medical University
Transgenic mice for imaging of cellular stress associated with diseases and agingPrincipal Investigator
- Principal Investigator
  
  IWAWAKI Takao
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 42040:Laboratory animal science-related
- Research Institution
  Kanazawa Medical University
Molecular mechanism of overeating regulated by cellular stress responsePrincipal Investigator
- Principal Investigator
  
  IWAWAKI Takao
- Project Period (FY)
  2015 – 2016
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Environmental physiology(including physical medicine and nutritional physiology)
- Research Institution
  Kanazawa Medical University
  Gunma University
異常タンパク質インターフェイスとしての天然変性領域の機能解析Principal Investigator
- Principal Investigator
  
  岩脇隆夫
- Project Period (FY)
  2012 – 2013
- Research Category
  
  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
- Review Section
  
  Biological Sciences
- Research Institution
  Gunma University
Physiological and Pathological Function of Cellular Stress ResponsesPrincipal Investigator
- Principal Investigator
  
  IWAWAKI Takao
- Project Period (FY)
  2012 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  General physiology
- Research Institution
  Gunma University
「天然」変性タンパク質による「非天然」変性タンパク質の感知・認識機構の解析Principal Investigator
- Principal Investigator
  
  岩脇隆夫
- Project Period (FY)
  2010 – 2011
- Research Category
  
  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
- Review Section
  
  Biological Sciences
- Research Institution
  Gunma University
  The Institute of Physical and Chemical Research
Identification of novel ER stress responsive pathways that function in intercellular interactionPrincipal Investigator
- Principal Investigator
  
  IWAWAKI Takao
- Project Period (FY)
  2009 – 2010
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  General physiology
- Research Institution
  The Institute of Physical and Chemical Research
小胞体ストレス細胞死における分子制御機構の解明Principal Investigator
- Principal Investigator
  
  岩脇隆夫
- Project Period (FY)
  2002 – 2003
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Neurochemistry/Neuropharmacology
- Research Institution
  The Institute of Physical and Chemical Research

All 2020 2019 2018 2017 2015 2014 2013 2012 2011 2010 2009 Other

All Journal Article Presentation Patent

[Journal Article] IRE1α regulates macrophage polarization, PD-L1 expression, and tumor survival2020
- Author(s)
  Batista Alyssa、Rodvold Jeffrey J.、Xian Su、Searles Stephen C.、Lew Alyssa、Iwawaki Takao、Almanza Gonzalo、Waller T. Cameron、Lin Jonathan、Jepsen Kristen、Carter Hannah、Zanetti Maurizio
- Journal Title
  
  PLOS Biology
  
  Volume: 18
- DOI
  10.1371/journal.pbio.3000687
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18H02366
[Journal Article] AAV-mediated ERdj5 overexpression protects against P23H rhodopsin toxicity2020
- Author(s)
  Aguila Monica、Bellingham James、Athanasiou Dimitra、Bevilacqua Dalila、Duran Yanai、Maswood Ryea、Parfitt David A、Iwawaki Takao、Spyrou Giannis、Smith Alexander J、Ali Robin R、Cheetham Michael E
- Journal Title
  
  Human Molecular Genetics
  
  Volume: 29 Pages: 1310-1318
- DOI
  10.1093/hmg/ddaa049
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18H02366
[Journal Article] Transgenic mouse model exhibiting weak red fluorescence before and strong green fluorescence after Cre/loxP-mediated recombination2020
- Author(s)
  Akai Ryoko、Saito Michiko、Kohno Kenji、Iwawaki Takao
- Journal Title
  
  Experimental Animals
  
  Volume: 69 Pages: 306-318
- DOI
  10.1538/expanim.19-0085
- NAID
  130007884759
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18H02366
[Journal Article] IRE1α Promotes Zika Virus Infection via XBP12020
- Author(s)
  Kolpikova Elena P.、Tronco Ana R.、Den Hartigh Andreas B.、Jackson Konner J.、Iwawaki Takao、Fink Susan L.
- Journal Title
  
  Viruses
  
  Volume: 12 Pages: 278-278
- DOI
  10.3390/v12030278
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18H02366
[Journal Article] Protective effect of dimethyl fumarate for the development of pressure ulcers after cutaneous ischemia‐reperfusion injury2020
- Author(s)
  Inoue Yuta、Uchiyama Akihiko、Sekiguchi Akiko、Yamazaki Sahori、Fujiwara Chisako、Yokoyama Yoko、Ogino Sachiko、Torii Ryoko、Hosoi Mari、Akai Ryoko、Iwawaki Takao、Ishikawa Osamu、Motegi Sei‐ichiro
- Journal Title
  
  Wound Repair and Regeneration
  
  Volume: 28 Pages: 600-608
- DOI
  10.1111/wrr.12824
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18H02366
[Journal Article] Protein quality control through endoplasmic reticulum-associated degradation maintains haematopoietic stem cell identity and niche interactions2020
- Author(s)
  Xu Longyong、Iwawaki Takao、Chen Xi et al
- Journal Title
  
  Nature Cell Biology
  
  Volume: 22 Pages: 1162-1169
- DOI
  10.1038/s41556-020-00581-x
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18H02366
[Journal Article] Apelin/APJ signaling suppresses the pressure ulcer formation in cutaneous ischemia-reperfusion injury mouse model2020
- Author(s)
  Yamazaki Sahori、Sekiguchi Akiko、Uchiyama Akihiko、Fujiwara Chisako、Inoue Yuta、Yokoyama Yoko、Ogino Sachiko、Torii Ryoko、Hosoi Mari、Akai Ryoko、Iwawaki Takao、Ishikawa Osamu、Motegi Sei-ichiro
- Journal Title
  
  Scientific Reports
  
  Volume: 10 Pages: 1349-1349
- DOI
  10.1038/s41598-020-58452-2
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18H02366
[Journal Article] Role of IRE1α in podocyte proteostasis and mitochondrial health2020
- Author(s)
  Navarro-Betancourt Jos? R.、Papillon Joan、Guillemette Julie、Iwawaki Takao、Chung Chen-Fang、Cybulsky Andrey V.
- Journal Title
  
  Cell Death Discovery
  
  Volume: 6 Pages: 128-128
- DOI
  10.1038/s41420-020-00361-4
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18H02366
[Journal Article] ERdj5 in Innate Immune Cells Is a Crucial Factor for the Mucosal Adjuvanticity of Cholera Toxin2019
- Author(s)
  Kim MS, Yi EJ, Kim YI, Kim SH, Jung YS, Kim SR, Iwawaki T, Ko HJ, Chang SY
- Journal Title
  
  Front Immunol
  
  Volume: 10 Pages: 1249-1249
- DOI
  10.3389/fimmu.2019.01249
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18H02366
[Journal Article] Zinc deficiency exacerbates pressure ulcers by increasing oxidative stress and ATP in the skin2019
- Author(s)
  Nakamura H, Sekiguchi A, Ogawa Y, Kawamura T, Akai R, Iwawaki T, Makiguchi T, Yokoo S, Ishikawa O, Motegi SI
- Journal Title
  
  J Dermatol Sci
  
  Volume: 95 Pages: 62-69
- DOI
  10.1016/j.jdermsci.2019.07.004
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18H02366, KAKENHI-PROJECT-19K21517
[Journal Article] Adaptive endoplasmic reticulum stress signalling via IRE1α-XBP1 preserves self-renewal of haematopoietic and pre-leukaemic stem cells2019
- Author(s)
  Liu L, Zhao M, Jin X, Ney G, Yang KB, Peng F, Cao J, Iwawaki T, Del Valle J, Chen X, Li Q
- Journal Title
  
  Nat Cell Biol
  
  Volume: 21 Pages: 328-337
- DOI
  10.1038/s41556-019-0285-6
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18H02366
[Journal Article] Salmonella exploits HLA-B27 and host unfolded protein responses to promote intracellular replication2019
- Author(s)
  Antoniou AN, Lenart I, Kriston-Vizi J, Iwawaki T, Turmaine M, McHugh K, Ali S, Blake N, Bowness P, Bajaj-Elliott M, Gould K, Nesbeth D, Powis SJ
- Journal Title
  
  Ann Rheum Dis
  
  Volume: 78 Pages: 74-82
- DOI
  10.1136/annrheumdis-2018-213532
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18H02366
[Journal Article] IRE1α-XBP1 signaling in leukocytes controls prostaglandin biosynthesis and pain2019
- Author(s)
  Chopra S, Giovanelli P, Alvarado-Vazquez PA, Alonso S, Song M, Sandoval TA, Chae CS, Tan C, Fonseca MM, Gutierrez S, Jimenez L, Subbaramaiah K, Iwawaki T, Kingsley PJ, Marnett LJ, Kossenkov AV, Crespo MS, Dannenberg AJ, Glimcher LH, Romero-Sandoval EA, Cubillos-Ruiz JR
- Journal Title
  
  Science
  
  Volume: 365
- DOI
  10.1126/science.aau6499
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18H02366
[Journal Article] IRE1α Activation in Bone Marrow-Derived Dendritic Cells Modulates Innate Recognition of Melanoma Cells and Favors CD8+ T Cell Priming2019
- Author(s)
  Medel B, Costoya C, Fernandez D, Pereda C, Lladser A, Sauma D, Pacheco R, Iwawaki T, Salazar-Onfray F, Osorio F
- Journal Title
  
  Front Immunol
  
  Volume: 9 Pages: 3050-3050
- DOI
  10.3389/fimmu.2018.03050
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18H02366
[Journal Article] Danger-associated extracellular ATP counters MDSC therapeutic efficacy in acute GVHD2019
- Author(s)
  Koehn BH, Saha A, McDonald-Hyman C, Loschi M, Thangavelu G, Ma L, Zaiken M, Dysthe J, Krepps W, Panthera J, Hippen K, Jameson SC, Miller JS, Cooper MA, Farady CJ, Iwawaki T, Ting JP, Serody JS, Murphy WJ, Hill GR, Murray PJ, Bronte V, Munn DH, Zeiser R, Blazar BR
- Journal Title
  
  Blood
  
  Volume: 134 Pages: 1670-1682
- DOI
  10.1182/blood.2019001950
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18H02366
[Journal Article] MITOL prevents ER stress-induced apoptosis by IRE1α ubiquitylation at ER-mitochondria contact sites.2019
- Author(s)
  Takeda, K., Nagashima, S., Shiiba, I., Uda, A., Tokuyama, T., Ito, N., Fukuda, T., Matsushita, N., Ishido, S., Iwawaki, T., Uehara, T., Inatome, R., and Yanagi, S.
- Journal Title
  
  The EMBO Journal
  
  Volume: 38
- DOI
  10.15252/embj.2018100999
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K22498, KAKENHI-PUBLICLY-18H04869, KAKENHI-PROJECT-17H04053, KAKENHI-PROJECT-18H02366, KAKENHI-PROJECT-18H02579, KAKENHI-PROJECT-17K08793, KAKENHI-PROJECT-19K16527
[Journal Article] Ablation of the Chaperone Protein ERdj5 Results in a Sjogren's Syndrome-Like Phenotype in Mice, Consistent With an Upregulated Unfolded Protein Response in Human Patients2019
- Author(s)
  Apostolou E, Moustardas P, Iwawaki T, Tzioufas AG, Spyrou G
- Journal Title
  
  Front Immunol
  
  Volume: 10 Pages: 506-506
- DOI
  10.3389/fimmu.2019.00506
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18H02366
[Journal Article] Molecular Mechanism of Cellular Oxidative Stress Sensing by Keap12019
- Author(s)
  Suzuki Takafumi、Muramatsu Aki、Saito Ryota、Iso Tatsuro、Shibata Takahiro、Kuwata Keiko、Kawaguchi Shin-ichi、Iwawaki Takao、Adachi Saki、Suda Hiromi、Morita Masanobu、Uchida Koji、Baird Liam、Yamamoto Masayuki
- Journal Title
  
  Cell Rep
  
  Volume: 28 Pages: 746-758
- DOI
  10.1016/j.celrep.2019.06.047
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K07340, KAKENHI-PROJECT-19K07341, KAKENHI-PROJECT-17KK0183, KAKENHI-PUBLICLY-18H04963, KAKENHI-PROJECT-19H05649, KAKENHI-PROJECT-19H00990, KAKENHI-PROJECT-19H01019, KAKENHI-PROJECT-18H02366, KAKENHI-PROJECT-18K19417, KAKENHI-ORGANIZER-15H05935
[Journal Article] Inhibitory effect of kaempferol on skin fibrosis in systemic sclerosis by the suppression of oxidative stress2019
- Author(s)
  Sekiguchi A, Motegi SI, Fujiwara C, Yamazaki S, Inoue Y, Uchiyama A, Akai R, Iwawaki T, Ishikawa O
- Journal Title
  
  J Dermatol Sci
  
  Volume: 96 Pages: 8-17
- DOI
  10.1016/j.jdermsci.2019.08.004
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18H02366, KAKENHI-PROJECT-19K21517
[Journal Article] IRE1-XBP1 pathway regulates oxidative proinsulin folding in pancreatic β cells2018
- Author(s)
  Yuichi Tsuchiya, Michiko Saito, Hiroshi Kadokura, Jun-ichi Miyazaki, Fumi Tashiro, Yusuke Imagawa, Takao Iwawaki, Kenji Kohno
- Journal Title
  
  The Journal of Cell Biology
  
  Volume: 217 Pages: 1287-1301
- DOI
  10.1083/jcb.201707143
- NAID
  120006457754
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15K07381, KAKENHI-PROJECT-24228002, KAKENHI-PLANNED-26116006, KAKENHI-PUBLICLY-18H05047, KAKENHI-PROJECT-17H01468, KAKENHI-PROJECT-18H02366, KAKENHI-PROJECT-17K15134, KAKENHI-PLANNED-26116005
[Journal Article] タンパク質恒常性と糖代謝異常に関わる小胞体ストレス応答の役割2018
- Author(s)
  岩脇隆夫
- Journal Title
  
  金沢医科大学雑誌
  
  Volume: 43 Pages: 15-22
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18H02366
[Journal Article] 小胞体ストレスの生体イメージング2018
- Author(s)
  岩脇隆夫, 赤井良子
- Journal Title
  
  THE BONE
  
  Volume: 32 Pages: 171-177
- Data Source
  KAKENHI-PROJECT-18H02366
[Journal Article] ERα promotes murine hematopoietic regeneration through the Ire1α-mediated unfolded protein response2018
- Author(s)
  Chapple RH, Hu T, Tseng YJ, Liu L, Kitano A, Luu V, Hoegenauer KA, Iwawaki T, Li Q, Nakada D
- Journal Title
  
  eLife
  
  Volume: 7
- DOI
  10.7554/elife.31159
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18H02366
[Journal Article] IRE1α governs cytoskeleton remodelling and cell migration through a direct interaction with filamin A2018
- Author(s)
  Urra H, Henriquez DR, Canovas J, Villarroel-Campos D, Carreras-Sureda A, Pulgar E, Molina E, Hazari YM, Limia CM, Alvarez-Rojas S, Figueroa R, Vidal RL, Rodriguez DA, Rivera CA, Court FA, Couve A, Qi L, Chevet E, Akai R, Iwawaki T, Concha ML, Glavic A, Gonzalez-Billault C, Hetz C
- Journal Title
  
  Nature Cell Biology
  
  Volume: 20 Pages: 942-953
- DOI
  10.1038/s41556-018-0141-0
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18H02366, KAKENHI-PROJECT-19K21517
[Journal Article] Botulinum toxin B suppresses the pressure ulcer formation in cutaneous ischemia-reperfusion injury mouse model: Possible regulation of oxidative and endoplasmic reticulum stress2018
- Author(s)
  Sekiguchi A, Motegi SI, Uchiyama A, Uehara A, Fujiwara C, Yamazaki S, Perera B, Nakamura H, Ogino S, Yokoyama Y, Akai R, Iwawaki T, Ishikawa O
- Journal Title
  
  Journal of Dermatological Science
  
  Volume: 90 Pages: 144-153
- DOI
  10.1016/j.jdermsci.2018.01.006
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18H02366, KAKENHI-PROJECT-19K21517
[Journal Article] Activation of Host IRE1α-Dependent Signaling Axis Contributes the Intracellular Parasitism of Brucella melitensis2018
- Author(s)
  Pandey A, Lin F, Cabello AL, da Costa LF, Feng X, Feng HQ, Zhang MZ, Iwawaki T, Rice-Ficht A, Ficht TA, de Figueiredo P, Qin QM
- Journal Title
  
  Frontiers in Cellular and Infection Microbiology
  
  Volume: 8 Pages: 103-103
- DOI
  10.3389/fcimb.2018.00103
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18H02366
[Journal Article] Stabilization of cytokine mRNAs in iNKT cells requires the serine-threonine?kinase IRE1alpha2018
- Author(s)
  Govindarajan S, Gaublomme D, Van der Cruyssen R, Verheugen E, Van Gassen S, Saeys Y, Tavernier S, Iwawaki T, Bloch Y, Savvides SN, Lambrecht BN, Janssens S, Elewaut D, Drennan MB
- Journal Title
  
  Nature Communications
  
  Volume: 9 Pages: 5340-5340
- DOI
  10.1038/s41467-018-07758-x
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18H02366
[Journal Article] Correlation between attenuation of protein disulfide isomerase activity through S-mercuration and neurotoxicity induced by methylmercury2015
- Author(s)
  Makino K, Okuda K, Sugino E, Nishiya T, Toyama T, Iwawaki T, Fujimura M, Kumagai Y, Uehara T.
- Journal Title
  
  Neurotoxicity Research
  
  Volume: 27 Pages: 99-105
- DOI
  10.1007/s12640-014-9494-8
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-12J03394, KAKENHI-PROJECT-24390049, KAKENHI-PROJECT-25220103, KAKENHI-PROJECT-25670029, KAKENHI-PLANNED-26111008, KAKENHI-PROJECT-26460068
[Journal Article] Protection afforded by pre- or post-treatment with 4-phenylbutyrate against liver injury induced by acetaminophen overdose in mice.2014
- Author(s)
  Daisuke Shimizua, Yoichi Ishitsuka, Keishi Miyata, Yoshiro Tomishima, Yuki Kondo, Mitsuru Irikura, Takao Iwawaki, Yuichi Oike, Tetsumi Irie
- Journal Title
  
  Pharmacol Res.
  
  Volume: 87 Pages: 26-41
- DOI
  10.1016/j.phrs.2014.06.003
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24390049, KAKENHI-PROJECT-25461114, KAKENHI-PUBLICLY-26116722, KAKENHI-PROJECT-26293190, KAKENHI-PROJECT-26670405
[Journal Article] Evaluating experimental cerebral malaria using oxidative stress indicator OKD48 mice2014
- Author(s)
  Imai T, Iwawaki T, Akai R, Suzue K, Hirai M, Taniguchi T, Okada H, Hisaeda H.
- Journal Title
  
  Int J Parasitol
  
  Volume: 44 Pages: 681-5
- DOI
  10.1016/j.ijpara.2014.06.002
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PUBLICLY-24112705, KAKENHI-PROJECT-24390049, KAKENHI-PROJECT-24590501, KAKENHI-PROJECT-25670226, KAKENHI-PROJECT-26860276, KAKENHI-PROJECT-26870094
[Journal Article] Temporal activation of Nrf2 in the penumbra and Nrf2 activator-mediated neuroprotection in ischemia-reperfusion injury.2014
- Author(s)
  Toshinori Takagi, Akira Kitashoji, Takao Iwawaki, Kazuhiro Tsuruma, Masamitsu Shimazawa, Shinichi Yoshimura, Toru Iwama, Hideaki Hara
- Journal Title
  
  Free Radic Biol Med
  
  Volume: 72 Pages: 124-133
- DOI
  10.1016/j.freeradbiomed.2014.04.009
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-24390049, KAKENHI-PROJECT-25861266
[Journal Article] The co-chaperone and reductase ERdj5 facilitates rod opsin biogenesis and quality control2014
- Author(s)
  Dimitra Athanasiou, Dalila Bevilacqua, Monica Aguila, Caroline McCulley, Naheed Kanuga, Takao Iwawaki, J. Paul Chapple, Michael E. Cheetham
- Journal Title
  
  Hum. Mol. Genet.
  
  Volume: 23 Pages: 6594-6606
- DOI
  10.1093/hmg/ddu385
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24390049
[Journal Article] A role for regulated IRE-1 dependent decay in curtailing immunoglobulin secretion from plasma cells2014
- Author(s)
  Sandrine Benhamron, Takao Iwawaki, Jae-Seon So, Ann-Hwee Lee, Boaz Tirosh
- Journal Title
  
  Eur. J. Immunol.
  
  Volume: 44 Pages: 867-876
- DOI
  10.1002/eji.201343953
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24390049
[Journal Article] Inositol-requiring enzyme 1-α regulates CD8α+ dendritic cell function via regulated mRNA decay2014
- Author(s)
  Fabiola Osorio, Simon Tavernier, Eik Hoffmann, Yvan Saeys, Liesbet Martens, Jessica Vetters, Iris Delrue, Riet De Rycke, Eef Parthoens, Philippe Poulliot, Takao Iwawaki, Sophie Janssens, Bart N. Lambrecht
- Journal Title
  
  Nat. Immunol.
  
  Volume: 15 Pages: 248-257
- DOI
  10.1038/ni.2808
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24390049
[Journal Article] Comparative analysis of ER stress response into HIV protease inhibitors : Lopinavir but not darunavir induces potent ER stress responsevia ROS/JNK pathway2013
- Author(s)
  Taura M, Kariya R, Kudo E, Goto H, Iwawaki T, Amano M, Suico MA, Kai H, Mitsuya H, Okada S.
- Journal Title
  
  Free Radic. Biol. Med.
  
  Volume: 65 Pages: 778-788
- DOI
  10.1016/j.freeradbiomed.2013.08.161
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-12J08328, KAKENHI-PROJECT-23390265, KAKENHI-PROJECT-24390049
[Journal Article] Membrane lipid saturation activates IRE1α without inducing clustering.2013
- Author(s)
  Yuto Kitai, Hiroyuki Ariyama, Nozomu Kono, Daisuke Oikawa, Takao Iwawaki, Hiroyuki Arai
- Journal Title
  
  Genes Cells.
  
  Volume: 18 Pages: 798-809
- DOI
  10.1111/gtc.12074
- Peer Reviewed
- Data Source
  KAKENHI-PUBLICLY-24113702, KAKENHI-PROJECT-25460060
[Journal Article] Paneth cells as a site of origin for intestinal inflammation2013
- Author(s)
  Adolph,T.E.,Tomczak,M.F.,Niederreiter,L.,Ko,H.J.,Bock,J.,Martinez-Naves,E.,Glickman,J.N.,Tschurtschenthaler,M.,Hartwig,J.,Hosomi,S.,Flak,M.B.,Cusick,J.L.,Kohno,K.,Iwawaki,T.,Billmann-Born,S.,Raine,T.,Bharti,R.,Lucius,R.,Kweon,M.N.,Marciniak,S.J.,Choi,A.,Hagen,S.J.,Schreiber,S.,Rosenstiel,P.,Kaser,A.,Blumberg,RS.
- Journal Title
  
  Nature
  
  Volume: 503 Pages: 272-276
- DOI
  10.1038/nature12599
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24228002, KAKENHI-PROJECT-24390049
[Journal Article] 小胞体ストレスシグナルの感知・生体防御機構2013
- Author(s)
  岩脇隆夫
- Journal Title
  
  細胞
  
  Volume: 45 Pages: 168-171
- Data Source
  KAKENHI-PROJECT-24390049
[Journal Article] 小胞体ストレスシグナルの感知・生体防御機構2013
- Author(s)
  岩脇　隆夫
- Journal Title
  
  細胞
  
  Volume: 45 Pages: 168-171
- Data Source
  KAKENHI-PUBLICLY-24113702
[Journal Article] 生きているマウスで酸化ストレスを見えるように2013
- Author(s)
  及川大輔、岩脇隆夫
- Journal Title
  
  化学と生物
  
  Volume: 51 Pages: 361-363
- Data Source
  KAKENHI-PROJECT-24390049
[Journal Article] CHOP is a critical regulator of acetaminophen-induced hepatotoxicity2013
- Author(s)
  Dotan Uzi, Liran Barda, Viviana Scaiewicz, Maya Mills, Tobias Mueller, Agueda Gonzalez-Rodriguez, Angela M. Valverde, Takao Iwawaki, Yaakov Nahmias, Ramnik J. Xavier, Raymond T. Chung, Boaz Tirosh, Oren Shibolet
- Journal Title
  
  J. Hepatol.
  
  Volume: 59 Pages: 495-503
- DOI
  10.1016/j.jhep.2013.04.024
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24390049
[Journal Article] ER stress transcription factor Xbp1 suppresses intestinal tumorigenesis and directs intestinal stem cells2013
- Author(s)
  Niederreiter, L., Fritz, T. M. J., Adolph, T.E., Krismer, A. M., Offner, F. A., Tschurtschenthaler, M., Flak, M. B., Hosomi, S., Tomczak, M. F., Kaneider, N. C., Sarcevic, E., Kempster, S. L., Raine, T., Esser, D., Rosenstiel, P., Kohno, K., Iwawaki, T., Tilg, H., Blumberg, R. S., and Kaser, A.
- Journal Title
  
  J. Exp. Med.
  
  Volume: 210(10) Pages: 2041-2056
- DOI
  10.1084/jem.20122341
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24228002, KAKENHI-PROJECT-24390049
[Journal Article] Identification of the redox partners of ERdj5 /JPDI, a PDI family member, from an animal tissue2013
- Author(s)
  Kadokura, H., Saito, M., Tsuru, A., Hosoda, A., Iwawaki, T., Inaba, K., & Kohno, K.
- Journal Title
  
  Biochem Biophys Res Commun.
  
  Volume: 440 Pages: 245-250
- DOI
  10.1016/j.bbrc.2013.09.063
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23500496, KAKENHI-PUBLICLY-24113702, KAKENHI-PROJECT-24228002, KAKENHI-PROJECT-24580141
[Journal Article] Microsomal Triglyceride Transfer Protein Inhibition Induces Endoplasmic Reticulum Stress and Increases Gene Transcription via Ire1α/cJun to Enhance Plasma ALT/AST2013
- Author(s)
  Josekutty, J., Iqbal, J., Iwawaki, T., Kohno, K., and Hussain, M.
- Journal Title
  
  J. Biol. Chem.
  
  Volume: 288(20) Pages: 14372-14383
- DOI
  10.1074/jbc.m113.459602
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24228002, KAKENHI-PROJECT-24390049
[Journal Article] The role of the unfolded protein response in diabetes mellitus2013
- Author(s)
  Takao Iwawaki, Daisuke Oikawa
- Journal Title
  
  Semin. Immunopathol.
  
  Volume: 35 Pages: 333-350
- DOI
  10.1007/s00281-013-0369-5
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24390049
[Journal Article] Positive contribution of IRE1α-XBP1 pathway to the expression of placental cathepsins2013
- Author(s)
  Daisuke Oikawa, Takao Iwawaki
- Journal Title
  
  Biochem. Biophys. Res. Commun.
  
  Volume: 433 Pages: 426-431
- DOI
  10.1016/j.bbrc.2013.02.119
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24390049
[Journal Article] 小胞体ストレスの可視化2012
- Author(s)
  岩脇　隆夫
- Journal Title
  
  生体の科学
  
  Volume: 65 Pages: 388-389
- Data Source
  KAKENHI-PUBLICLY-24113702
[Journal Article] 小胞体ストレスの可視化2012
- Author(s)
  岩脇隆夫
- Journal Title
  
  生体の科学
  
  Volume: 65 Pages: 388-389
- Data Source
  KAKENHI-PROJECT-24390049
[Journal Article] Function of yeast and amphioxus tRNA ligase in IRE1alpha-dependent XBP1 mRNA splicing2011
- Author(s)
  Takao Iwawaki
- Journal Title
  
  Biochem.Biophys.Res.Commun.
  
  Volume: 413 Pages: 527-531
- DOI
  10.1016/j.bbrc.2011.08.129
- Peer Reviewed
- Data Source
  KAKENHI-PUBLICLY-22113524
[Journal Article] Positive contribution of the IRE1alpha-XBP1 pathway to placental expression of CEA family genes.2010
- Author(s)
  Daisuke Oikawa, Ryoko Akai, Takao Iwawaki
- Journal Title
  
  FEBS Lett. vol.584
  
  Pages: 1066-1070
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21790218
[Journal Article] Positive contribution of Erdj5/JPDI to endoplasmic reticulum protein quality control in the salivary gland.2010
- Author(s)
  Akira Hosoda, Mio Tokuda, Ryoko Akai, Kenji Kohno, Takao Iwawaki
- Journal Title
  
  Biochem. J. vol.425
  
  Pages: 117-125
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21790218
[Journal Article] IRE1alpha disruption causes histological abnormality of exocrine tissues, increase of blood glucose level, and decrease of serum immunoglobulin level.2010
- Author(s)
  Takao Iwawaki
- Journal Title
  
  PLoS ONE
  
  Volume: 5
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21790218
[Journal Article] The endoplasmic reticulum stress-CHOP pathway-mediated apoptosis in macrophages contributes to the instability of atherosclerotic plaques.2010
- Author(s)
  Hirato Tsukano, Tomomi Gotoh, Motoyoshi Endo, Miyata Keishi, Hirokazu Tazume, Tsuyoshi Kadomatsu, Masato Yano, Takao Iwawaki, Kenji Kohno, Kimi Araki, Hiroshi Mizuta, Yuichi Oike
- Journal Title
  
  Arterioscler. Thromb. Vasc.Biol. vol.30
  
  Pages: 1925-1932
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21790218
[Journal Article] IRE1alpha disruption causes histological abnormality of exocrine tissues, increase of blood glucose level, and decrease of serum immunoglobulin level.2010
- Author(s)
  Takao Iwawaki, Ryoko Akai, Kenji Kohno
- Journal Title
  
  PLoS ONE vol.5
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21790218
[Journal Article] Identication of a consensus element recognized and cleaved by IRE1alpha.2010
- Author(s)
  Daisuke Oikawa, Mio Tokuda, Akira Hosoda, Takao Iwawaki
- Journal Title
  
  Nucleic Acid Res. vol.38
  
  Pages: 6265-6273
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21790218
[Journal Article] Function of IRE1 alpha in the placenta is essential for placental development and embryonic viability.2009
- Author(s)
  Takao Iwawaki, Ryoko Akai, Shinya Yamanaka, Kenji Kohno
- Journal Title
  
  Proc.Natl.Acad.Sci.USA vol.106
  
  Pages: 16657-16662
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21790218
[Journal Article] Function of IRE1 Alpha in the Placenta is Essential for Placental Development and Embryonic Viability2009
- Author(s)
  Takao Iwawaki
- Journal Title
  
  Proc.Natl.Acad.Sci.USA 106
  
  Pages: 16657-16662
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21790218
[Patent] 炎症レポーターシステム2014
- Inventor(s)
  岩脇隆夫、及川大輔、石川智夫、山村研一
- Industrial Property Rights Holder
  群馬大学、熊本大学、株式会社トランスジェニック
- Industrial Property Rights Type
  特許
- Filing Date
  2014-07-31
- Overseas
- Data Source
  KAKENHI-PROJECT-24390049
[Patent] 酸化ストレスインジケーター発現用核酸構築物とその使用2012
- Inventor(s)
  岩脇隆夫, 及川大輔
- Industrial Property Rights Holder
  独立行政法人理化学研究所
- Filing Date
  2012-01-20
- Overseas
- Data Source
  KAKENHI-PUBLICLY-22113524
[Presentation] ストレス可視化モデルマウスの開発と疲労研究への応用2020
- Author(s)
  岩脇隆夫、赤井良子
- Organizer
  第16回日本疲労学会総会・学術集会
- Data Source
  KAKENHI-PROJECT-18H02366
[Presentation] IRE1α Is Essential for Podocyte Proteostasis and Mitochondrial Health2020
- Author(s)
  Jose R. Navarro-Betancourt, Joan Papillon, Julie Guillemette, Takao Iwawaki, Andrey V. Cybulsky
- Organizer
  KIDNEY WEEK 2020
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18H02366
[Presentation] Role of IRE1α in Podocyte Proteostasis2019
- Author(s)
  Jose R Navarro-Betancourt, Joan Papillon, Julie Guillemette, Takao Iwawaki, Andrey V Cybulsky
- Organizer
  KIDNEY WEEK 2019
- Data Source
  KAKENHI-PROJECT-18H02366
[Presentation] Comparison between endoscopic and histopathological findings in patients with ulcerative colitis2019
- Author(s)
  Tetsuo Nakayama, Shiko Kuribayashi, Junko Hirato, Takao Iwawaki, Ko Nakata, Hirohito Tanaka, Taku Tomizawa, Hiroko Hosaka, Yasuyuki Shimoyama, Osamu Kawamura, Motoyasu Kusano, Toshio Uraoka
- Organizer
  Digestive Disease Week 2019
- Data Source
  KAKENHI-PROJECT-18H02366
[Presentation] 睡眠不足モデルマウスにおける細胞ストレス応答と炎症反応の生体イメージング2019
- Author(s)
  赤井良子、岩脇隆夫
- Organizer
  第66回日本実験動物学会
- Data Source
  KAKENHI-PROJECT-18H02366
[Presentation] 小胞体ストレス応答分子により制御される過食行動の分子メカニズム2019
- Author(s)
  岩脇隆夫、赤井良子
- Organizer
  第14回臨床ストレス応答学会大会
- Data Source
  KAKENHI-PROJECT-18H02366
[Presentation] ATF4の翻訳活性化機構を利用した統合ストレス可視化モデルマウスの開発2018
- Author(s)
  赤井良子, 岩脇隆夫
- Organizer
  住商ファーマインターナショナル株式会社in vivoイメージングフォーラム2018
- Data Source
  KAKENHI-PROJECT-18H02366
[Presentation] 細菌によって利用される宿主細胞の生体防御反応～小胞体ストレス応答～2018
- Author(s)
  岩脇隆夫
- Organizer
  第55回日本細菌学会中部支部学術集会
- Invited
- Data Source
  KAKENHI-PROJECT-18H02366
[Presentation] 細胞ストレスおよび炎症可視化モデルマウスの開発とその性能2018
- Author(s)
  岩脇隆夫
- Organizer
  第342回熊本大学・発生研セミナー
- Invited
- Data Source
  KAKENHI-PROJECT-18H02366
[Presentation] ATF4の翻訳活性化機構を利用した統合ストレス可視化モデルマウスの開発と疲労研究への応用2018
- Author(s)
  岩脇隆夫, 赤井良子
- Organizer
  第14回日本疲労学会総会・学術集会
- Data Source
  KAKENHI-PROJECT-18H02366
[Presentation] 細胞ストレスおよび炎症可視化モデルマウスの開発とその性能2018
- Author(s)
  岩脇隆夫
- Organizer
  第16回京都薬科大学・実験動物セミナー
- Invited
- Data Source
  KAKENHI-PROJECT-18H02366
[Presentation] 『見えない』を『見える』にするマウス2018
- Author(s)
  岩脇隆夫
- Organizer
  第20回KMU研究推進セミナー
- Data Source
  KAKENHI-PROJECT-18H02366
[Presentation] ATF4の翻訳活性化機構を利用した統合ストレス可視化モデルマウスの開発2018
- Author(s)
  赤井良子, 岩脇隆夫
- Organizer
  第65回日本実験動物学会
- Data Source
  KAKENHI-PROJECT-18H02366
[Presentation] 異常行動およびエイジングにまで拡がる小胞体ストレス研究の新展開2017
- Author(s)
  岩脇隆夫
- Organizer
  東京大学大学院薬学系研究科遺伝学教室主催研究集会2017
- Place of Presentation
  和光純薬湯河原研修所（静岡県熱海市）
- Year and Date
  2017-03-12
- Data Source
  KAKENHI-PROJECT-15K15038
[Presentation] 酸化ストレス可視化マウスを用いた脳マラリアの新しい評価法2014
- Author(s)
  今井孝、岩脇隆夫、赤井良子、鈴江一友、平井誠、谷口委代、岡田紘子、久枝一
- Organizer
  第83回日本寄生虫学会大会
- Place of Presentation
  愛媛大学
- Data Source
  KAKENHI-PROJECT-24390049
[Presentation] The role of ER stress responses in the control of blood glucose and the biosynthesis of insulin2014
- Author(s)
  Ryoko Akai, Takao Iwawaki
- Organizer
  7th APOCB Congress and ASCB Workshops
- Place of Presentation
  Biopolis（シンガポール）
- Data Source
  KAKENHI-PROJECT-24390049
[Presentation] Positive contribution of IRE1α-XBP1 pathway to the expression of placental cathepsins2014
- Author(s)
  Takao Iwawaki, Daisuke Oikawa
- Organizer
  7th APOCB Congress and ASCB Workshops
- Place of Presentation
  Biopolis（シンガポール）
- Data Source
  KAKENHI-PROJECT-24390049
[Presentation] 胎盤でのCathepsin遺伝子発現制御におけるIRE1αおよびXBP1の役割2013
- Author(s)
  岩脇隆夫、及川大輔
- Organizer
  第60回北関東医学会総会
- Place of Presentation
  群馬大学
- Data Source
  KAKENHI-PROJECT-24390049
[Presentation] Fatty acid flux regulates IRE1α activity to control the NLRP3 inflammasome in myeloid cells2013
- Author(s)
  Megan Robblee, Jess P. Abate, Alex Samocha, Takao Iwawaki, Suneil K. Koliwad
- Organizer
  The 2013 Meeting on Metabolic Signaling & Disease
- Place of Presentation
  Cold Spring Harbor（米国）
- Data Source
  KAKENHI-PROJECT-24390049
[Presentation] Intrinsically disordered regions in handling of misfolded/unfolded proteins in the ER2013
- Author(s)
  Takao Iwawaki
- Organizer
  The 2nd ISIDP International Symposium
- Place of Presentation
  RIKEN, Yokohama
- Year and Date
  2013-01-23
- Data Source
  KAKENHI-PUBLICLY-24113702
[Presentation] 細胞ストレス可視化モデルマウスの開発とその性能2013
- Author(s)
  岩脇隆夫
- Organizer
  第86回日本生化学会バイオインダストリーセミナー
- Place of Presentation
  パシフィコ横浜
- Invited
- Data Source
  KAKENHI-PROJECT-24390049
[Presentation] 細胞内異常タンパク質代謝における天然変性領域の役割2012
- Author(s)
  岩脇隆夫
- Organizer
  新学術領域研究「天然変性タンパク質の分子認識機構と機能発現」第2回公開シンポジウム
- Place of Presentation
  千里ラィフサイェンスセンター(招待講演)
- Year and Date
  2012-01-25
- Data Source
  KAKENHI-PUBLICLY-22113524
[Presentation] 小胞体ストレスを『より簡便』に検出する方法2012
- Author(s)
  岩脇隆夫
- Organizer
  日本薬学会第132年会
- Place of Presentation
  北海道大学(招待講演)
- Year and Date
  2012-03-29
- Data Source
  KAKENHI-PUBLICLY-22113524
[Presentation] 細胞ストレス可視化モデルマウスの開発とその性能2012
- Author(s)
  岩脇隆夫
- Organizer
  細胞センサーの分子機構・相互作用・ネットワーク研究会
- Place of Presentation
  生理学研究所
- Data Source
  KAKENHI-PROJECT-24390049
[Presentation] 酸化ストレス可視化モデルマウスの開発2012
- Author(s)
  岩脇隆夫
- Organizer
  第8回日本疲労学会総会・学術集会
- Place of Presentation
  国立スポーツ科学センター
- Data Source
  KAKENHI-PROJECT-24390049
[Presentation] IRE1αとIRE1βによる小胞体ストレス感知機構の違い2012
- Author(s)
  岩脇　隆夫
- Organizer
  第7回小胞体ストレス研究会
- Place of Presentation
  広島大学
- Year and Date
  2012-11-09
- Data Source
  KAKENHI-PUBLICLY-24113702
[Presentation] 胎盤における小胞体ストレス応答分子の機能2012
- Author(s)
  岩脇隆夫
- Organizer
  第4回群馬分子医学研究会
- Place of Presentation
  群馬大学
- Year and Date
  2012-10-20
- Data Source
  KAKENHI-PROJECT-24390049
[Presentation] 動物個体における小胞体ストレスと酸化ストレスのイメージング技術の開発2011
- Author(s)
  岩脇隆夫
- Organizer
  第10回国際バイオEXPO
- Place of Presentation
  東京ビッグサイト
- Year and Date
  2011-06-30
- Data Source
  KAKENHI-PUBLICLY-22113524
[Presentation] Screening for XBP1 splicing-associated RNA ligase2011
- Author(s)
  岩脇隆夫
- Organizer
  第34回日本分子生物学会年会
- Place of Presentation
  パシフィコ横浜
- Year and Date
  2011-12-15
- Data Source
  KAKENHI-PUBLICLY-22113524
[Presentation] Transgenic mouse models for monitoring cellular stress2011
- Author(s)
  Iwawaki Takao
- Organizer
  奈良先端未来開拓コロキウム"Protein and Organelle Dynamics under Cellular Stress Conditions"
- Place of Presentation
  奈良先端科学技術大学院大学(招待講演)
- Year and Date
  2011-05-31
- Data Source
  KAKENHI-PUBLICLY-22113524
[Presentation] 酸化ストレス可視化モデルマウスの開発2011
- Author(s)
  岩脇隆夫
- Organizer
  第6回IVISユーザー会
- Place of Presentation
  パシフィコ横浜(招待講演)
- Year and Date
  2011-11-04
- Data Source
  KAKENHI-PUBLICLY-22113524
[Presentation] XBP1のスプライシングに関わるRNAリガーゼのスクリーニング2011
- Author(s)
  岩脇隆夫
- Organizer
  第63回日本細胞生物学会
- Place of Presentation
  北海道大学
- Year and Date
  2011-06-27
- Data Source
  KAKENHI-PUBLICLY-22113524
[Presentation] マウス個体における酸化ストレスイメージングシステムの開発2011
- Author(s)
  岩脇隆夫
- Organizer
  第6回臨床ストレス応答学会
- Place of Presentation
  名古屋大学医学部
- Year and Date
  2011-11-05
- Data Source
  KAKENHI-PUBLICLY-22113524
[Presentation] 膵臓β細胞でのインスリン産生におけるIRE1とATF6の役割2010
- Author(s)
  藤岡洋美、土屋雄一、斉藤美知子、岩脇隆夫、森和俊、河野憲二
- Organizer
  第33回日本分子生物学会・第83回日本生化学会合同年会
- Place of Presentation
  神戸
- Year and Date
  2010-12-10
- Data Source
  KAKENHI-PROJECT-21790218
[Presentation] The role of ER stress responses in the control of blood glucose levels and the biosynthesis of insulin2010
- Author(s)
  Takao Iwawaki
- Organizer
  The 3rd International Symposium on Protein Community
- Place of Presentation
  Nara
- Year and Date
  2010-09-13
- Data Source
  KAKENHI-PROJECT-21790218
[Presentation] The role of ER stress responses in the control of blood glucose levels and the biosynthesis of insulin2010
- Author(s)
  Takao Iwawaki, Akira Hosoda, Ryoko Akai, Mio Tokuda
- Organizer
  The 3rd International Symposium on Protein Community
- Place of Presentation
  in Nara
- Year and Date
  2010-09-13
- Data Source
  KAKENHI-PROJECT-21790218
[Presentation] 血糖値調節およびインスリン生合成における小胞体ストレス応答の役割2010
- Author(s)
  岩脇隆夫
- Organizer
  第5回臨床ストレス応答学会
- Place of Presentation
  徳島
- Year and Date
  2010-11-19
- Data Source
  KAKENHI-PROJECT-21790218
[Presentation] 血糖値調節およびインスリン生合成における小胞体ストレス応答の役割2010
- Author(s)
  岩脇隆夫、細田章、赤井良子、徳田美緒
- Organizer
  第33回日本分子生物学会・第83回日本生化学会合同年会
- Place of Presentation
  神戸
- Year and Date
  2010-12-10
- Data Source
  KAKENHI-PROJECT-21790218
[Presentation] 血糖値調節およびインスリン生合成における小胞体ストレス応答の役割2010
- Author(s)
  岩脇隆夫、細田章、赤井良子、徳田美緒
- Organizer
  第5回臨床ストレス応答学会
- Place of Presentation
  徳島大
- Year and Date
  2010-11-19
- Data Source
  KAKENHI-PROJECT-21790218
[Presentation] 胎盤形成における小胞体ストレスセンサーとビタミンEの役割2009
- Author(s)
  岩脇隆夫
- Organizer
  エーザイ株式会社第12回Vitamin E Update Forum
- Place of Presentation
  如水会館、東京
- Year and Date
  2009-08-31
- Data Source
  KAKENHI-PROJECT-21790218
[Presentation] Contribution of IRE1 signaling to placental angiogenesis and functuion for embryogenesis2009
- Author(s)
  岩脇隆夫
- Organizer
  The 4th International Congress on Stress Responses in Biology and Medicine
- Place of Presentation
  Sapporo
- Year and Date
  2009-10-08
- Data Source
  KAKENHI-PROJECT-21790218
[Presentation] Genome-wide screening method for the cleavage target of IRE1alpha2009
- Author(s)
  Daisuke Oikawa, Mio Tokuda, Akira Hosoda, Takao Iwawaki
- Organizer
  The 32nd Annual Meeting of the Molecular Biology Society of Japan
- Place of Presentation
  in Yokohama
- Year and Date
  2009-12-12
- Data Source
  KAKENHI-PROJECT-21790218
[Presentation] Positive contribution of ERdj5/JPDI to endoplasmic reticulum protein quality control in the salivary gland2009
- Author(s)
  Akira Hosoda, Mio Tokuda, Ryoko Akai, Kenji Kohno, Takao Iwawaki
- Organizer
  The 4th International Congress on Stress Responses in Biology and Medicine
- Place of Presentation
  in Sapporo
- Year and Date
  2009-10-08
- Data Source
  KAKENHI-PROJECT-21790218
[Presentation] Phenotype analysis of IRE1 alpha conditional knockout mice2009
- Author(s)
  Ryoko Akai, Kenji Kohno, Takao Iwawaki
- Organizer
  The 4th International Congress on Stress Responses in Biology and Medicine
- Place of Presentation
  in Sapporo
- Year and Date
  2009-10-08
- Data Source
  KAKENHI-PROJECT-21790218
[Presentation] 胎盤形成における小胞体ストレスセンサーとビタミンEの役割2009
- Author(s)
  岩脇隆夫
- Organizer
  エーザイ株式会社第12回 Vitamin E Update Forum
- Place of Presentation
  東京
- Year and Date
  2009-08-31
- Data Source
  KAKENHI-PROJECT-21790218
[Presentation] PSG遺伝子群の胎盤発現に対するIRE1a-XBP1経路の貢献2009
- Author(s)
  及川大輔、赤井良子、岩脇隆夫
- Organizer
  第61回日本細胞生物学会
- Place of Presentation
  名古屋
- Year and Date
  2009-06-04
- Data Source
  KAKENHI-PROJECT-21790218
[Presentation] Positive contribution of ERdj5/JPDI to endoplasmic reticulum protein quality control in the salivary gland2009
- Author(s)
  Akira Hosoda, Mio Tokuda, Ryoko Akai, Kenji Kohno, Takao Iwawaki
- Organizer
  The 32nd Annual Meeting of the Molecular Biology Society of Japan
- Place of Presentation
  in Yokohama
- Year and Date
  2009-12-12
- Data Source
  KAKENHI-PROJECT-21790218
[Presentation] Contribution of IRE1alpha-XBP1 pathway to the placental expression of PSG genes2009
- Author(s)
  Daisuke Oikawa, Ryoko Akai, Takao Iwawaki
- Organizer
  The 4th International Congress on Stress Responses in Biology and Medicine, Poster Presentation
- Place of Presentation
  in Sapporo
- Year and Date
  2009-10-08
- Data Source
  KAKENHI-PROJECT-21790218
[Presentation] Contribution of IRE1 signaling to placental angiogenesis and function for embryogenesis2009
- Author(s)
  Takao Iwawaki, Ryoko Akai, Shinya Yamanaka, Kenji Kohno
- Organizer
  The 4th International Congress on Stress Responses in Biology and Medicine
- Place of Presentation
  in Sapporo
- Year and Date
  2009-10-08
- Data Source
  KAKENHI-PROJECT-21790218
[Presentation] 群馬大学で名付けられた遺伝子、IRE1
- Author(s)
  岩脇隆夫
- Organizer
  第61回北関東医学会総会
- Place of Presentation
  群馬大（群馬県前橋市）
- Year and Date
  2014-09-25 – 2014-09-26
- Data Source
  KAKENHI-PROJECT-24390049
[Presentation] 細胞ストレス可視化モデルマウスの開発とその性能
- Author(s)
  岩脇隆夫
- Organizer
  岡山大＆理研ジョイントシンポジウム「最先端計測技術のトレンド2013」
- Place of Presentation
  岡山大学
- Invited
- Data Source
  KAKENHI-PROJECT-24390049
[Presentation] 動物個体レベルでみる小胞体ストレス応答分子IRE1αの役割
- Author(s)
  岩脇隆夫
- Organizer
  第122回東京大学生命環境科学セミナー
- Place of Presentation
  東京大学
- Invited
- Data Source
  KAKENHI-PROJECT-24390049
[Presentation] 小胞体ストレス応答不全による糖尿病発症機構の解明
- Author(s)
  斉藤美知子、土屋雄一、岩脇隆夫、森和俊、宮崎純一、河野憲二
- Organizer
  第37回日本分子生物学会年会
- Place of Presentation
  パシフィコ横浜（神奈川県横浜市）
- Year and Date
  2014-11-25 – 2014-11-27
- Data Source
  KAKENHI-PROJECT-24390049
[Presentation] Unfolded protein response is differently activated by membrane lipid saturation and unfolded proteins in the endoplasmic reticulum
- Author(s)
  Nozomu Kono, Yuto Kitai, Hiroyuki Ariyama, Daisuke Oikawa, Takao Iwawaki, Hiroyuki Arai
- Organizer
  FASEB SRC: Phospholipid Cell Signaling and Metabolism in Inflammation and Cancer
- Place of Presentation
  Niagara Falls (USA)
- Year and Date
  2014-06-01 – 2014-06-06
- Data Source
  KAKENHI-PROJECT-24390049
[Presentation] メチル水銀誘発性神経細胞死における小胞体ストレスの関与
- Author(s)
  奥田洸作、牧野堅人、外山喬士、西屋禎、岩脇隆夫、熊谷嘉人、上原孝
- Organizer
  第123回日本薬理学会近畿部会
- Place of Presentation
  ウインクあいち
- Data Source
  KAKENHI-PROJECT-24390049
[Presentation] 細胞ストレス可視化モデルマウスの開発とその性能
- Author(s)
  岩脇隆夫
- Organizer
  第5回実験動物センター・テクニカルセミナー
- Place of Presentation
  東京医科歯科大学
- Invited
- Data Source
  KAKENHI-PROJECT-24390049
[Presentation] 細胞ストレス可視化モデルマウスの開発とその性能
- Author(s)
  岩脇隆夫
- Organizer
  第8回医工連携グループミーティング
- Place of Presentation
  群馬大学
- Invited
- Data Source
  KAKENHI-PROJECT-24390049
[Presentation] インスリン生合成に必要な膵臓ベータ細胞におけるeIF2αキナーゼとホスファターゼのバランス機構
- Author(s)
  岩脇隆夫、赤井良子、細田章、徳田美緒
- Organizer
  第37回日本分子生物学会年会
- Place of Presentation
  パシフィコ横浜（神奈川県横浜市）
- Year and Date
  2014-11-25 – 2014-11-27
- Data Source
  KAKENHI-PROJECT-24390049
[Presentation] 小胞体ストレスセンサーIRE1αによる細胞質スプライシングに必要なmRNAの構造及び配列の解析
- Author(s)
  池端悠介、今川佑介、柳谷耕太、田丸良子、金谷重彦、岩脇隆夫、河野憲二
- Organizer
  第66回日本細胞生物学会
- Place of Presentation
  東大寺総合文化センター（奈良県奈良市）
- Year and Date
  2014-06-11 – 2014-06-13
- Data Source
  KAKENHI-PROJECT-24390049
[Presentation] インスリン産生細胞における小胞体ストレスセンサーIRE1alphaの生理的役割
- Author(s)
  土屋雄一、斉藤美知子、岩脇隆夫、宮崎純一、河野憲二
- Organizer
  第66回日本細胞生物学会
- Place of Presentation
  東大寺総合文化センター（奈良県奈良市）
- Year and Date
  2014-06-11 – 2014-06-13
- Data Source
  KAKENHI-PROJECT-24390049

1. OIKAWA Daisuke

# of Collaborated Projects: 1 results

# of Collaborated Products: 6 results
2. TAKAHASHI Yayoi

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
3. ASAI Chiaki

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
4. YOSHINO Mayuko

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
5. AKAI Ryoko

# of Collaborated Projects: 1 results

# of Collaborated Products: 4 results
6. SAITO Michiko

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
7. IMAGAWA Yusuke

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
8. KONO Nozomu

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
9. NISHIYA Tadashi

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
10. SUZUKI Takafumi

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
11. MORITA Masanobu

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
12. MORITA Hironobu

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
13. 満屋裕明

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
14. 門倉広

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
15. 河野憲二

# of Collaborated Projects: 0 results

# of Collaborated Products: 5 results
16. 宮田敬士

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
17. 尾池雄一

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
18. 平井誠

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
19. 久枝一

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
20. 今井孝

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
21. 谷口委代

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
22. 都留秋雄

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
23. 高木俊範

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
24. 上原孝

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
25. 柳茂

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
26. 伊藤昭博

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
27. 福田敏史

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
28. 熊谷嘉人

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
29. 山本雅之

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
30. 望田啓子

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Iwawaki Takao 岩脇 隆夫

IWAWAKI Takao 岩脇 隆夫

岩脇 隆夫 イワワキ タカオ

Research Projects

Research Products

Co-Researchers

細胞ストレスと炎症の発展的研究から迫る「疲労」メカニズムの分子細胞生物学的な解明Principal Investigator

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Transgenic mice for imaging of cellular stress associated with diseases and agingPrincipal Investigator

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Molecular mechanism of overeating regulated by cellular stress responsePrincipal Investigator

Principal Investigator

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異常タンパク質インターフェイスとしての天然変性領域の機能解析Principal Investigator

Principal Investigator

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Physiological and Pathological Function of Cellular Stress ResponsesPrincipal Investigator

Principal Investigator

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「天然」変性タンパク質による「非天然」変性タンパク質の感知・認識機構の解析Principal Investigator

Principal Investigator

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Identification of novel ER stress responsive pathways that function in intercellular interactionPrincipal Investigator

Principal Investigator

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小胞体ストレス細胞死における分子制御機構の解明Principal Investigator

Principal Investigator

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Research Institution

[Journal Article] IRE1α regulates macrophage polarization, PD-L1 expression, and tumor survival2020

Author(s)

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DOI

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[Journal Article] AAV-mediated ERdj5 overexpression protects against P23H rhodopsin toxicity2020

Author(s)

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DOI

Data Source

[Journal Article] Transgenic mouse model exhibiting weak red fluorescence before and strong green fluorescence after Cre/loxP-mediated recombination2020

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DOI

NAID

Data Source

[Journal Article] IRE1α Promotes Zika Virus Infection via XBP12020

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DOI

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[Journal Article] Protective effect of dimethyl fumarate for the development of pressure ulcers after cutaneous ischemia‐reperfusion injury2020

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Iwawaki Takao 岩脇隆夫

IWAWAKI Takao 岩脇隆夫

岩脇隆夫イワワキタカオ