IWAWAKI Takao 岩脇隆夫

Researcher Number	50342754
Other IDs
Affiliation *help	2016 – 2018 : 金沢医科大学, 総合医学研究所, 教授 2015 : 群馬大学, 医学(系)研究科(研究院), 講師 2011 – 2014 : 群馬大学, 先端科学研究指導者育成ユニット, 講師 2010 : The Institute of Physical and Chemical Research, 中野生体膜研究室, 客員主管研究員 2009 : The Institute of Physical and Chemical Research, 岩脇独立主幹研究ユニット, ユニットリーダー(独立主幹研究員) 2003 : 理研, 研究員 2002 : 理化学研究所, 細胞修復機構研究チーム, 基礎科学特別研究員
Review Section/Research Field	Principal Investigator General physiology / Biological Sciences / Neurochemistry/Neuropharmacology / Environmental physiology(including physical medicine and nutritional physiology) / Basic Section 42040:Laboratory animal science-related
Keywords	Principal Investigator 小胞体ストレス / タンパク質品質管理 / IRE1 / 細胞ストレス / 胎盤 / 生体イメージング / 膵臓 / エリスロポエチン / ムチン / ＩＲＥ１ … More

疾患および老化研究に必要不可欠なストレス可視化マウスの開発Principal InvestigatorOngoing
- Principal Investigator
  
  岩脇隆夫
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 42040:Laboratory animal science-related
- Research Institution
  Kanazawa Medical University
Molecular mechanism of overeating regulated by cellular stress responsePrincipal Investigator
- Principal Investigator
  
  IWAWAKI Takao
- Project Period (FY)
  2015 – 2016
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Environmental physiology(including physical medicine and nutritional physiology)
- Research Institution
  Kanazawa Medical University
  Gunma University
異常タンパク質インターフェイスとしての天然変性領域の機能解析Principal Investigator
- Principal Investigator
  
  岩脇隆夫
- Project Period (FY)
  2012 – 2013
- Research Category
  
  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
- Review Section
  
  Biological Sciences
- Research Institution
  Gunma University
Physiological and Pathological Function of Cellular Stress ResponsesPrincipal Investigator
- Principal Investigator
  
  IWAWAKI Takao
- Project Period (FY)
  2012 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  General physiology
- Research Institution
  Gunma University
「天然」変性タンパク質による「非天然」変性タンパク質の感知・認識機構の解析Principal Investigator
- Principal Investigator
  
  岩脇隆夫
- Project Period (FY)
  2010 – 2011
- Research Category
  
  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
- Review Section
  
  Biological Sciences
- Research Institution
  Gunma University
  The Institute of Physical and Chemical Research
Identification of novel ER stress responsive pathways that function in intercellular interactionPrincipal Investigator
- Principal Investigator
  
  IWAWAKI Takao
- Project Period (FY)
  2009 – 2010
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  General physiology
- Research Institution
  The Institute of Physical and Chemical Research
小胞体ストレス細胞死における分子制御機構の解明Principal Investigator
- Principal Investigator
  
  岩脇隆夫
- Project Period (FY)
  2002 – 2003
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Neurochemistry/Neuropharmacology
- Research Institution
  The Institute of Physical and Chemical Research

All 2017 2015 2014 2013 2012 2011 2010 2009 Other

All Journal Article Presentation

[Journal Article] Correlation between attenuation of protein disulfide isomerase activity through S-mercuration and neurotoxicity induced by methylmercury2015
- Author(s)
  Makino K, Okuda K, Sugino E, Nishiya T, Toyama T, Iwawaki T, Fujimura M, Kumagai Y, Uehara T.
- Journal Title
  
  Neurotox. Res.
  
  Volume : 27 Pages : 99-105
- DOI
  10.1007/s12640-014-9494-8
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-12J03394, KAKENHI-PROJECT-24390049, KAKENHI-PROJECT-25220103, KAKENHI-PROJECT-25670029, KAKENHI-PLANNED-26111008, KAKENHI-PROJECT-26460068
[Journal Article] Membrane lipidsaturation activates IRE1α without clustering2015
- Author(s)
  Kimihiko Sugaya, Yoshie Ishihara and Sonoe Inoue
- Journal Title
  
  Genes Cells
  
  Volume : in press Pages : 798-809
- DOI
  10.1111/gtc.12074
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-23570012, KAKENHI-PUBLICLY-24113702, KAKENHI-PROJECT-25460060
[Journal Article] A role for regulated IRE-1 dependent decay in curtailing immunoglobulin secretion from plasma cells2014
- Author(s)
  Sandrine Benhamron, Takao Iwawaki, Jae-Seon So, Ann-Hwee Lee, Boaz Tirosh
- Journal Title
  
  Eur. J. Immunol.
  
  Volume : 44 Pages : 867-876
- DOI
  10.1002/eji.201343953
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24390049
[Journal Article] Evaluating experimental cerebral malaria using oxidative stress indicator OKD48 mice2014
- Author(s)
  Imai T, Iwawaki T, Akai R, Suzue K, Hirai M, Taniguchi T, Okada H, Hisaeda H.
- Journal Title
  
  Int. J. Parasitol.
  
  Volume : 44 Pages : 681-685
- DOI
  10.1016/j.ijpara.2014.06.002
- Peer Reviewed / Open Access / Acknowledgement Compliant
- Data Source
  KAKENHI-PUBLICLY-24112705, KAKENHI-PROJECT-24390049, KAKENHI-PROJECT-24590501, KAKENHI-PROJECT-25670226, KAKENHI-PROJECT-26860276, KAKENHI-PROJECT-26870094
[Journal Article] Inositol-requiring enzyme 1-α regulates CD8α+ dendritic cell function via regulated mRNA decay2014
- Author(s)
  Fabiola Osorio, Simon Tavernier, Eik Hoffmann, Yvan Saeys, Liesbet Martens, Jessica Vetters, Iris Delrue, Riet De Rycke, Eef Parthoens, Philippe Poulliot, Takao Iwawaki, Sophie Janssens, Bart N. Lambrecht
- Journal Title
  
  Nat. Immunol.
  
  Volume : 15 Pages : 248-257
- DOI
  10.1038/ni.2808
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24390049
[Journal Article] Temporal activation of Nrf2 in the penumbra and Nrf2 activator-mediated neuroprotection in ischemia-reperfusion injury.2014
- Author(s)
  Toshinori Takagi, Akira Kitashoji, Takao Iwawaki, Kazuhiro Tsuruma, Masamitsu Shimazawa, Shinichi Yoshimura, Toru Iwama, Hideaki Hara
- Journal Title
  
  Free Radic Biol Med
  
  Volume : 72 Pages : 124-133
- DOI
  10.1016/j.freeradbiomed.2014.04.009
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-24390049, KAKENHI-PROJECT-25861266
[Journal Article] Protection afforded by pre- or post-treatment with 4-phenylbutyrate against liver injury induced by acetaminophen overdose in mice.2014
- Author(s)
  Daisuke Shimizua, Yoichi Ishitsuka, Keishi Miyata, Yoshiro Tomishima, Yuki Kondo, Mitsuru Irikura, Takao Iwawaki, Yuichi Oike, Tetsumi Irie
- Journal Title
  
  Pharmacol Res.
  
  Volume : 87 Pages : 26-41
- DOI
  10.1016/j.phrs.2014.06.003
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24390049, KAKENHI-PROJECT-25461114, KAKENHI-PUBLICLY-26116722, KAKENHI-PROJECT-26293190, KAKENHI-PROJECT-26670405
[Journal Article] The co-chaperone and reductase ERdj5 facilitates rod opsin biogenesis and quality control2014
- Author(s)
  Dimitra Athanasiou, Dalila Bevilacqua, Monica Aguila, Caroline McCulley, Naheed Kanuga, Takao Iwawaki, J. Paul Chapple, Michael E. Cheetham
- Journal Title
  
  Hum. Mol. Genet.
  
  Volume : 23 Pages : 6594-6606
- DOI
  10.1093/hmg/ddu385
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24390049
[Journal Article] Identification of the redox partners of ERdj5 /JPDI, a PDI family member, from an animal tissue2013
- Author(s)
  Kadokura, H., Saito, M., Tsuru, A., Hosoda, A., Iwawaki, T., Inaba, K., & Kohno, K.
- Journal Title
  
  Biochem. Biophys. Res. Commun.
  
  Volume : 440 Pages : 245-250
- DOI
  10.1016/j.bbrc.2013.09.063
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23500496, KAKENHI-PUBLICLY-24113702, KAKENHI-PROJECT-24228002, KAKENHI-PROJECT-24580141
[Journal Article] CHOP is a critical regulator of acetaminophen-induced hepatotoxicity2013
- Author(s)
  Dotan Uzi, Liran Barda, Viviana Scaiewicz, Maya Mills, Tobias Mueller, Agueda Gonzalez-Rodriguez, Angela M. Valverde, Takao Iwawaki, Yaakov Nahmias, Ramnik J. Xavier, Raymond T. Chung, Boaz Tirosh, Oren Shibolet
- Journal Title
  
  J. Hepatol.
  
  Volume : 59 Pages : 495-503
- DOI
  10.1016/j.jhep.2013.04.024
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24390049
[Journal Article] Positive contribution of IRE1α-XBP1 pathway to the expression of placental cathepsins2013
- Author(s)
  Daisuke Oikawa, Takao Iwawaki
- Journal Title
  
  Biochem. Biophys. Res. Commun.
  
  Volume : 433 Pages : 426-431
- DOI
  10.1016/j.bbrc.2013.02.119
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24390049
[Journal Article] ER stress transcription factor Xbp1 suppresses intestinal tumorigenesis and directs intestinal stem cells2013
- Author(s)
  Niederreiter, L., Fritz, T. M. J., Adolph, T.E., Krismer, A. M., Offner, F. A., Tschurtschenthaler, M., Flak, M. B., Hosomi, S., Tomczak, M. F., Kaneider, N. C., Sarcevic, E., Kempster, S. L., Raine, T., Esser, D., Rosenstiel, P., Kohno, K., Iwawaki, T., Tilg, H., Blumberg, R. S., and Kaser, A.
- Journal Title
  
  J. Exp. Med.
  
  Volume : 210(10) Pages : 2041-2056
- DOI
  10.1084/jem.20122341
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24228002, KAKENHI-PROJECT-24390049
[Journal Article] Microsomal Triglyceride Transfer Protein Inhibition Induces Endoplasmic Reticulum Stress and Increases Gene Transcription via Ire1α/cJun to Enhance Plasma ALT/AST2013
- Author(s)
  Josekutty, J., Iqbal, J., Iwawaki, T., Kohno, K., and Hussain, M.
- Journal Title
  
  J. Biol. Chem.
  
  Volume : 288(20) Pages : 14372-14383
- DOI
  10.1074/jbc.M113.459602
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24228002, KAKENHI-PROJECT-24390049
[Journal Article] The role of the unfolded protein response in diabetes mellitus2013
- Author(s)
  Takao Iwawaki, Daisuke Oikawa
- Journal Title
  
  Semin. Immunopathol.
  
  Volume : 35 Pages : 333-350
- DOI
  10.1007/s00281-013-0369-5
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24390049
[Journal Article] Paneth cells as a site of origin for intestinal inflammation2013
- Author(s)
  Adolph,T.E.,Tomczak,M.F.,Niederreiter,L.,Ko,H.J.,Bock,J.,Martinez-Naves,E.,Glickman,J.N.,Tschurtschenthaler,M.,Hartwig,J.,Hosomi,S.,Flak,M.B.,Cusick,J.L.,Kohno,K.,Iwawaki,T.,Billmann-Born,S.,Raine,T.,Bharti,R.,Lucius,R.,Kweon,M.N.,Marciniak,S.J.,Choi,A.,Hagen,S.J.,Schreiber,S.,Rosenstiel,P.,Kaser,A.,Blumberg,RS.
- Journal Title
  
  Nature
  
  Volume : 503 Pages : 272-276
- DOI
  10.1038/nature12599
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24228002, KAKENHI-PROJECT-24390049
[Journal Article] 小胞体ストレスシグナルの感知・生体防御機構2013
- Author(s)
  岩脇　隆夫
- Journal Title
  
  細胞
  
  Volume : 45 Pages : 168-171
- Data Source
  KAKENHI-PUBLICLY-24113702
[Journal Article] 小胞体ストレスシグナルの感知・生体防御機構2013
- Author(s)
  岩脇隆夫
- Journal Title
  
  細胞
  
  Volume : 45 Pages : 168-171
- Data Source
  KAKENHI-PROJECT-24390049
[Journal Article] 生きているマウスで酸化ストレスを見えるように2013
- Author(s)
  及川大輔、岩脇隆夫
- Journal Title
  
  化学と生物
  
  Volume : 51 Pages : 361-363
- Data Source
  KAKENHI-PROJECT-24390049
[Journal Article] Comparative analysis of ER stress response into HIV protease inhibitors : Lopinavir but not darunavir induces potent ER stress responsevia ROS/JNK pathway2013
- Author(s)
  Taura M, Kariya R, Kudo E, Goto H, Iwawaki T, Amano M, Suico MA, Kai H, Mitsuya H, Okada S.
- Journal Title
  
  Free Radic. Biol. Med.
  
  Volume : 65 Pages : 778-788
- DOI
  10.1016/j.freeradbiomed.2013.08.161
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-12J08328, KAKENHI-PROJECT-23390265, KAKENHI-PROJECT-24390049
[Journal Article] 小胞体ストレスの可視化2012
- Author(s)
  岩脇隆夫
- Journal Title
  
  生体の科学
  
  Volume : 65 Pages : 388-389
- Data Source
  KAKENHI-PROJECT-24390049
[Journal Article] 小胞体ストレスの可視化2012
- Author(s)
  岩脇　隆夫
- Journal Title
  
  生体の科学
  
  Volume : 65 Pages : 388-389
- Data Source
  KAKENHI-PUBLICLY-24113702
[Journal Article] Function of yeast and amphioxus tRNA ligase in IRE1alpha-dependent XBP1 mRNA splicing2011
- Author(s)
  Takao Iwawaki
- Journal Title
  
  Biochem.Biophys.Res.Commun.
  
  Volume : 413 Pages : 527-531
- DOI
  10.1016/j.bbrc.2011.08.129
- Peer Reviewed
- Data Source
  KAKENHI-PUBLICLY-22113524
[Journal Article] Positive contribution of the IRE1alpha-XBP1 pathway to placental expression of CEA family genes.2010
- Author(s)
  Daisuke Oikawa, Ryoko Akai, Takao Iwawaki
- Journal Title
  
  FEBS Lett. vol.584
  
  Pages : 1066-1070
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21790218
[Journal Article] Positive contribution of Erdj5/JPDI to endoplasmic reticulum protein quality control in the salivary gland.2010
- Author(s)
  Akira Hosoda, Mio Tokuda, Ryoko Akai, Kenji Kohno, Takao Iwawaki
- Journal Title
  
  Biochem. J. vol.425
  
  Pages : 117-125
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21790218
[Journal Article] IRE1alpha disruption causes histological abnormality of exocrine tissues, increase of blood glucose level, and decrease of serum immunoglobulin level.2010
- Author(s)
  Takao Iwawaki
- Journal Title
  
  PLoS ONE
  
  Volume : 5
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21790218
[Journal Article] IRE1alpha disruption causes histological abnormality of exocrine tissues, increase of blood glucose level, and decrease of serum immunoglobulin level.2010
- Author(s)
  Takao Iwawaki, Ryoko Akai, Kenji Kohno
- Journal Title
  
  PLoS ONE vol.5
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21790218
[Journal Article] Identication of a consensus element recognized and cleaved by IRE1alpha.2010
- Author(s)
  Daisuke Oikawa, Mio Tokuda, Akira Hosoda, Takao Iwawaki
- Journal Title
  
  Nucleic Acid Res. vol.38
  
  Pages : 6265-6273
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21790218
[Journal Article] The endoplasmic reticulum stress-CHOP pathway-mediated apoptosis in macrophages contributes to the instability of atherosclerotic plaques.2010
- Author(s)
  Hirato Tsukano, Tomomi Gotoh, Motoyoshi Endo, Miyata Keishi, Hirokazu Tazume, Tsuyoshi Kadomatsu, Masato Yano, Takao Iwawaki, Kenji Kohno, Kimi Araki, Hiroshi Mizuta, Yuichi Oike
- Journal Title
  
  Arterioscler. Thromb. Vasc.Biol. vol.30
  
  Pages : 1925-1932
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21790218
[Journal Article] Function of IRE1 alpha in the placenta is essential for placental development and embryonic viability.2009
- Author(s)
  Takao Iwawaki, Ryoko Akai, Shinya Yamanaka, Kenji Kohno
- Journal Title
  
  Proc.Natl.Acad.Sci.USA vol.106
  
  Pages : 16657-16662
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21790218
[Journal Article] Function of IRE1 Alpha in the Placenta is Essential for Placental Development and Embryonic Viability2009
- Author(s)
  Takao Iwawaki
- Journal Title
  
  Proc.Natl.Acad.Sci.USA 106
  
  Pages : 16657-16662
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21790218
[Presentation] 異常行動およびエイジングにまで拡がる小胞体ストレス研究の新展開2017
- Author(s)
  岩脇隆夫
- Organizer
  東京大学大学院薬学系研究科遺伝学教室主催研究集会2017
- Place of Presentation
  和光純薬湯河原研修所（静岡県熱海市）
- Year and Date
  2017-03-12
- Data Source
  KAKENHI-PROJECT-15K15038
[Presentation] The role of ER stress responses in the control of blood glucose and the biosynthesis of insulin2014
- Author(s)
  Ryoko Akai, Takao Iwawaki
- Organizer
  7th APOCB Congress and ASCB Workshops
- Place of Presentation
  Biopolis（シンガポール）
- Data Source
  KAKENHI-PROJECT-24390049
[Presentation] Positive contribution of IRE1α-XBP1 pathway to the expression of placental cathepsins2014
- Author(s)
  Takao Iwawaki, Daisuke Oikawa
- Organizer
  7th APOCB Congress and ASCB Workshops
- Place of Presentation
  Biopolis（シンガポール）
- Data Source
  KAKENHI-PROJECT-24390049
[Presentation] 酸化ストレス可視化マウスを用いた脳マラリアの新しい評価法2014
- Author(s)
  今井孝、岩脇隆夫、赤井良子、鈴江一友、平井誠、谷口委代、岡田紘子、久枝一
- Organizer
  第83回日本寄生虫学会大会
- Place of Presentation
  愛媛大学
- Data Source
  KAKENHI-PROJECT-24390049
[Presentation] Intrinsically disordered regions in handling of misfolded/unfolded proteins in the ER2013
- Author(s)
  Takao Iwawaki
- Organizer
  The 2nd ISIDP International Symposium
- Place of Presentation
  RIKEN, Yokohama
- Year and Date
  2013-01-23
- Data Source
  KAKENHI-PUBLICLY-24113702
[Presentation] 細胞ストレス可視化モデルマウスの開発とその性能2013
- Author(s)
  岩脇隆夫
- Organizer
  第86回日本生化学会バイオインダストリーセミナー
- Place of Presentation
  パシフィコ横浜
- Invited
- Data Source
  KAKENHI-PROJECT-24390049
[Presentation] Fatty acid flux regulates IRE1α activity to control the NLRP3 inflammasome in myeloid cells2013
- Author(s)
  Megan Robblee, Jess P. Abate, Alex Samocha, Takao Iwawaki, Suneil K. Koliwad
- Organizer
  The 2013 Meeting on Metabolic Signaling & Disease
- Place of Presentation
  Cold Spring Harbor（米国）
- Data Source
  KAKENHI-PROJECT-24390049
[Presentation] 胎盤でのCathepsin遺伝子発現制御におけるIRE1αおよびXBP1の役割2013
- Author(s)
  岩脇隆夫、及川大輔
- Organizer
  第60回北関東医学会総会
- Place of Presentation
  群馬大学
- Data Source
  KAKENHI-PROJECT-24390049
[Presentation] 細胞ストレス可視化モデルマウスの開発とその性能2012
- Author(s)
  岩脇隆夫
- Organizer
  細胞センサーの分子機構・相互作用・ネットワーク研究会
- Place of Presentation
  生理学研究所
- Data Source
  KAKENHI-PROJECT-24390049
[Presentation] 胎盤における小胞体ストレス応答分子の機能2012
- Author(s)
  岩脇隆夫
- Organizer
  第4回群馬分子医学研究会
- Place of Presentation
  群馬大学
- Year and Date
  2012-10-20
- Data Source
  KAKENHI-PROJECT-24390049
[Presentation] 酸化ストレス可視化モデルマウスの開発2012
- Author(s)
  岩脇隆夫
- Organizer
  第8回日本疲労学会総会・学術集会
- Place of Presentation
  国立スポーツ科学センター
- Data Source
  KAKENHI-PROJECT-24390049
[Presentation] IRE1αとIRE1βによる小胞体ストレス感知機構の違い2012
- Author(s)
  岩脇　隆夫
- Organizer
  第7回小胞体ストレス研究会
- Place of Presentation
  広島大学
- Year and Date
  2012-11-09
- Data Source
  KAKENHI-PUBLICLY-24113702
[Presentation] 小胞体ストレスを『より簡便』に検出する方法2012
- Author(s)
  岩脇隆夫
- Organizer
  日本薬学会第132年会
- Place of Presentation
  北海道大学(招待講演)
- Year and Date
  2012-03-29
- Data Source
  KAKENHI-PUBLICLY-22113524
[Presentation] 細胞内異常タンパク質代謝における天然変性領域の役割2012
- Author(s)
  岩脇隆夫
- Organizer
  新学術領域研究「天然変性タンパク質の分子認識機構と機能発現」第2回公開シンポジウム
- Place of Presentation
  千里ラィフサイェンスセンター(招待講演)
- Year and Date
  2012-01-25
- Data Source
  KAKENHI-PUBLICLY-22113524
[Presentation] マウス個体における酸化ストレスイメージングシステムの開発2011
- Author(s)
  岩脇隆夫
- Organizer
  第6回臨床ストレス応答学会
- Place of Presentation
  名古屋大学医学部
- Year and Date
  2011-11-05
- Data Source
  KAKENHI-PUBLICLY-22113524
[Presentation] Screening for XBP1 splicing-associated RNA ligase2011
- Author(s)
  岩脇隆夫
- Organizer
  第34回日本分子生物学会年会
- Place of Presentation
  パシフィコ横浜
- Year and Date
  2011-12-15
- Data Source
  KAKENHI-PUBLICLY-22113524
[Presentation] Transgenic mouse models for monitoring cellular stress2011
- Author(s)
  Iwawaki Takao
- Organizer
  奈良先端未来開拓コロキウム"Protein and Organelle Dynamics under Cellular Stress Conditions"
- Place of Presentation
  奈良先端科学技術大学院大学(招待講演)
- Year and Date
  2011-05-31
- Data Source
  KAKENHI-PUBLICLY-22113524
[Presentation] XBP1のスプライシングに関わるRNAリガーゼのスクリーニング2011
- Author(s)
  岩脇隆夫
- Organizer
  第63回日本細胞生物学会
- Place of Presentation
  北海道大学
- Year and Date
  2011-06-27
- Data Source
  KAKENHI-PUBLICLY-22113524
[Presentation] 動物個体における小胞体ストレスと酸化ストレスのイメージング技術の開発2011
- Author(s)
  岩脇隆夫
- Organizer
  第10回国際バイオEXPO
- Place of Presentation
  東京ビッグサイト
- Year and Date
  2011-06-30
- Data Source
  KAKENHI-PUBLICLY-22113524
[Presentation] 酸化ストレス可視化モデルマウスの開発2011
- Author(s)
  岩脇隆夫
- Organizer
  第6回IVISユーザー会
- Place of Presentation
  パシフィコ横浜(招待講演)
- Year and Date
  2011-11-04
- Data Source
  KAKENHI-PUBLICLY-22113524
[Presentation] 膵臓β細胞でのインスリン産生におけるIRE1とATF6の役割2010
- Author(s)
  藤岡洋美、土屋雄一、斉藤美知子、岩脇隆夫、森和俊、河野憲二
- Organizer
  第33回日本分子生物学会・第83回日本生化学会合同年会
- Place of Presentation
  神戸
- Year and Date
  2010-12-10
- Data Source
  KAKENHI-PROJECT-21790218
[Presentation] The role of ER stress responses in the control of blood glucose levels and the biosynthesis of insulin2010
- Author(s)
  Takao Iwawaki, Akira Hosoda, Ryoko Akai, Mio Tokuda
- Organizer
  The 3rd International Symposium on Protein Community
- Place of Presentation
  in Nara
- Year and Date
  2010-09-13
- Data Source
  KAKENHI-PROJECT-21790218
[Presentation] The role of ER stress responses in the control of blood glucose levels and the biosynthesis of insulin2010
- Author(s)
  Takao Iwawaki
- Organizer
  The 3rd International Symposium on Protein Community
- Place of Presentation
  Nara
- Year and Date
  2010-09-13
- Data Source
  KAKENHI-PROJECT-21790218
[Presentation] 血糖値調節およびインスリン生合成における小胞体ストレス応答の役割2010
- Author(s)
  岩脇隆夫、細田章、赤井良子、徳田美緒
- Organizer
  第33回日本分子生物学会・第83回日本生化学会合同年会
- Place of Presentation
  神戸
- Year and Date
  2010-12-10
- Data Source
  KAKENHI-PROJECT-21790218
[Presentation] 血糖値調節およびインスリン生合成における小胞体ストレス応答の役割2010
- Author(s)
  岩脇隆夫、細田章、赤井良子、徳田美緒
- Organizer
  第5回臨床ストレス応答学会
- Place of Presentation
  徳島大
- Year and Date
  2010-11-19
- Data Source
  KAKENHI-PROJECT-21790218
[Presentation] 血糖値調節およびインスリン生合成における小胞体ストレス応答の役割2010
- Author(s)
  岩脇隆夫
- Organizer
  第33回日本分子生物学会・第83回日本生化学会合同年会
- Place of Presentation
  神戸
- Year and Date
  2010-12-10
- Data Source
  KAKENHI-PROJECT-21790218
[Presentation] 血糖値調節およびインスリン生合成における小胞体ストレス応答の役割2010
- Author(s)
  岩脇隆夫
- Organizer
  第5回臨床ストレス応答学会
- Place of Presentation
  徳島
- Year and Date
  2010-11-19
- Data Source
  KAKENHI-PROJECT-21790218
[Presentation] 胎盤形成における小胞体ストレスセンサーとビタミンEの役割2009
- Author(s)
  岩脇隆夫
- Organizer
  エーザイ株式会社第12回 Vitamin E Update Forum
- Place of Presentation
  東京
- Year and Date
  2009-08-31
- Data Source
  KAKENHI-PROJECT-21790218
[Presentation] Contribution of IRE1 signaling to placental angiogenesis and functuion for embryogenesis2009
- Author(s)
  岩脇隆夫
- Organizer
  The 4th International Congress on Stress Responses in Biology and Medicine
- Place of Presentation
  Sapporo
- Year and Date
  2009-10-08
- Data Source
  KAKENHI-PROJECT-21790218
[Presentation] Positive contribution of ERdj5/JPDI to endoplasmic reticulum protein quality control in the salivary gland2009
- Author(s)
  Akira Hosoda, Mio Tokuda, Ryoko Akai, Kenji Kohno, Takao Iwawaki
- Organizer
  The 32nd Annual Meeting of the Molecular Biology Society of Japan
- Place of Presentation
  in Yokohama
- Year and Date
  2009-12-12
- Data Source
  KAKENHI-PROJECT-21790218
[Presentation] Contribution of IRE1 signaling to placental angiogenesis and function for embryogenesis2009
- Author(s)
  Takao Iwawaki, Ryoko Akai, Shinya Yamanaka, Kenji Kohno
- Organizer
  The 4th International Congress on Stress Responses in Biology and Medicine
- Place of Presentation
  in Sapporo
- Year and Date
  2009-10-08
- Data Source
  KAKENHI-PROJECT-21790218
[Presentation] PSG遺伝子群の胎盤発現に対するIRE1a-XBP1経路の貢献2009
- Author(s)
  及川大輔、赤井良子、岩脇隆夫
- Organizer
  第61回日本細胞生物学会
- Place of Presentation
  名古屋
- Year and Date
  2009-06-04
- Data Source
  KAKENHI-PROJECT-21790218
[Presentation] 胎盤形成における小胞体ストレスセンサーとビタミンEの役割2009
- Author(s)
  岩脇隆夫
- Organizer
  エーザイ株式会社第12回Vitamin E Update Forum
- Place of Presentation
  如水会館、東京
- Year and Date
  2009-08-31
- Data Source
  KAKENHI-PROJECT-21790218
[Presentation] Contribution of IRE1alpha-XBP1 pathway to the placental expression of PSG genes2009
- Author(s)
  Daisuke Oikawa, Ryoko Akai, Takao Iwawaki
- Organizer
  The 4th International Congress on Stress Responses in Biology and Medicine, Poster Presentation
- Place of Presentation
  in Sapporo
- Year and Date
  2009-10-08
- Data Source
  KAKENHI-PROJECT-21790218
[Presentation] Positive contribution of ERdj5/JPDI to endoplasmic reticulum protein quality control in the salivary gland2009
- Author(s)
  Akira Hosoda, Mio Tokuda, Ryoko Akai, Kenji Kohno, Takao Iwawaki
- Organizer
  The 4th International Congress on Stress Responses in Biology and Medicine
- Place of Presentation
  in Sapporo
- Year and Date
  2009-10-08
- Data Source
  KAKENHI-PROJECT-21790218
[Presentation] Phenotype analysis of IRE1 alpha conditional knockout mice2009
- Author(s)
  Ryoko Akai, Kenji Kohno, Takao Iwawaki
- Organizer
  The 4th International Congress on Stress Responses in Biology and Medicine
- Place of Presentation
  in Sapporo
- Year and Date
  2009-10-08
- Data Source
  KAKENHI-PROJECT-21790218
[Presentation] Genome-wide screening method for the cleavage target of IRE1alpha2009
- Author(s)
  Daisuke Oikawa, Mio Tokuda, Akira Hosoda, Takao Iwawaki
- Organizer
  The 32nd Annual Meeting of the Molecular Biology Society of Japan
- Place of Presentation
  in Yokohama
- Year and Date
  2009-12-12
- Data Source
  KAKENHI-PROJECT-21790218
[Presentation] 小胞体ストレス応答不全による糖尿病発症機構の解明
- Author(s)
  斉藤美知子、土屋雄一、岩脇隆夫、森和俊、宮崎純一、河野憲二
- Organizer
  第37回日本分子生物学会年会
- Place of Presentation
  パシフィコ横浜（神奈川県横浜市）
- Year and Date
  2014-11-25 – 2014-11-27
- Data Source
  KAKENHI-PROJECT-24390049
[Presentation] 小胞体ストレスセンサーIRE1αによる細胞質スプライシングに必要なmRNAの構造及び配列の解析
- Author(s)
  池端悠介、今川佑介、柳谷耕太、田丸良子、金谷重彦、岩脇隆夫、河野憲二
- Organizer
  第66回日本細胞生物学会
- Place of Presentation
  東大寺総合文化センター（奈良県奈良市）
- Year and Date
  2014-06-11 – 2014-06-13
- Data Source
  KAKENHI-PROJECT-24390049
[Presentation] 動物個体レベルでみる小胞体ストレス応答分子IRE1αの役割
- Author(s)
  岩脇隆夫
- Organizer
  第122回東京大学生命環境科学セミナー
- Place of Presentation
  東京大学
- Invited
- Data Source
  KAKENHI-PROJECT-24390049
[Presentation] 細胞ストレス可視化モデルマウスの開発とその性能
- Author(s)
  岩脇隆夫
- Organizer
  第5回実験動物センター・テクニカルセミナー
- Place of Presentation
  東京医科歯科大学
- Invited
- Data Source
  KAKENHI-PROJECT-24390049
[Presentation] 細胞ストレス可視化モデルマウスの開発とその性能
- Author(s)
  岩脇隆夫
- Organizer
  岡山大＆理研ジョイントシンポジウム「最先端計測技術のトレンド2013」
- Place of Presentation
  岡山大学
- Invited
- Data Source
  KAKENHI-PROJECT-24390049
[Presentation] メチル水銀誘発性神経細胞死における小胞体ストレスの関与
- Author(s)
  奥田洸作、牧野堅人、外山喬士、西屋禎、岩脇隆夫、熊谷嘉人、上原孝
- Organizer
  第123回日本薬理学会近畿部会
- Place of Presentation
  ウインクあいち
- Data Source
  KAKENHI-PROJECT-24390049
[Presentation] 細胞ストレス可視化モデルマウスの開発とその性能
- Author(s)
  岩脇隆夫
- Organizer
  第8回医工連携グループミーティング
- Place of Presentation
  群馬大学
- Invited
- Data Source
  KAKENHI-PROJECT-24390049
[Presentation] 群馬大学で名付けられた遺伝子、IRE1
- Author(s)
  岩脇隆夫
- Organizer
  第61回北関東医学会総会
- Place of Presentation
  群馬大（群馬県前橋市）
- Year and Date
  2014-09-25 – 2014-09-26
- Data Source
  KAKENHI-PROJECT-24390049
[Presentation] インスリン産生細胞における小胞体ストレスセンサーIRE1alphaの生理的役割
- Author(s)
  土屋雄一、斉藤美知子、岩脇隆夫、宮崎純一、河野憲二
- Organizer
  第66回日本細胞生物学会
- Place of Presentation
  東大寺総合文化センター（奈良県奈良市）
- Year and Date
  2014-06-11 – 2014-06-13
- Data Source
  KAKENHI-PROJECT-24390049
[Presentation] Unfolded protein response is differently activated by membrane lipid saturation and unfolded proteins in the endoplasmic reticulum
- Author(s)
  Nozomu Kono, Yuto Kitai, Hiroyuki Ariyama, Daisuke Oikawa, Takao Iwawaki, Hiroyuki Arai
- Organizer
  FASEB SRC: Phospholipid Cell Signaling and Metabolism in Inflammation and Cancer
- Place of Presentation
  Niagara Falls (USA)
- Year and Date
  2014-06-01 – 2014-06-06
- Data Source
  KAKENHI-PROJECT-24390049
[Presentation] インスリン生合成に必要な膵臓ベータ細胞におけるeIF2αキナーゼとホスファターゼのバランス機構
- Author(s)
  岩脇隆夫、赤井良子、細田章、徳田美緒
- Organizer
  第37回日本分子生物学会年会
- Place of Presentation
  パシフィコ横浜（神奈川県横浜市）
- Year and Date
  2014-11-25 – 2014-11-27
- Data Source
  KAKENHI-PROJECT-24390049

1. OIKAWA Daisuke

# of Collaborated Projects : 1results

# of Collaborated Products : 6results
2. TAKAHASHI Yayoi

# of Collaborated Projects : 1results

# of Collaborated Products : 0results
3. ASAI Chiaki

# of Collaborated Projects : 1results

# of Collaborated Products : 0results
4. YOSHINO Mayuko

# of Collaborated Projects : 1results

# of Collaborated Products : 0results
5. AKAI Ryoko

# of Collaborated Projects : 1results

# of Collaborated Products : 0results
6. TAKAGI Toshinori

# of Collaborated Projects : 0results

# of Collaborated Products : 1results
7. OIKE Yuichi

# of Collaborated Projects : 0results

# of Collaborated Products : 1results
8. MIYATA KEISHI

# of Collaborated Projects : 0results

# of Collaborated Products : 1results
9. SUGAYA Kimihiko

# of Collaborated Projects : 0results

# of Collaborated Products : 1results
10. ISHIHARA Yoshie

# of Collaborated Projects : 0results

# of Collaborated Products : 1results
11. INOUE Sonoe

# of Collaborated Projects : 0results

# of Collaborated Products : 1results
12. MITSUYA Hiroaki

# of Collaborated Projects : 0results

# of Collaborated Products : 1results
13. 斉藤美知子

# of Collaborated Projects : 0results

# of Collaborated Products : 1results
14. 河野憲二

# of Collaborated Projects : 0results

# of Collaborated Products : 4results
15. 都留秋雄

# of Collaborated Projects : 0results

# of Collaborated Products : 1results
16. 門倉広

# of Collaborated Projects : 0results

# of Collaborated Products : 1results
17. 平井誠

# of Collaborated Projects : 0results

# of Collaborated Products : 1results
18. 久枝一

# of Collaborated Projects : 0results

# of Collaborated Products : 1results
19. 今井孝

# of Collaborated Projects : 0results

# of Collaborated Products : 1results
20. 谷口委代

# of Collaborated Projects : 0results

# of Collaborated Products : 1results
21. 熊谷嘉人

# of Collaborated Projects : 0results

# of Collaborated Products : 1results
22. 上原孝

# of Collaborated Projects : 0results

# of Collaborated Products : 1results
23. 西屋禎

# of Collaborated Projects : 0results

# of Collaborated Products : 1results
24. 河野望

# of Collaborated Projects : 0results

# of Collaborated Products : 1results

IWAWAKI Takao 岩脇 隆夫

Research Projects

Research Products

Co-Researchers

疾患および老化研究に必要不可欠なストレス可視化マウスの開発Principal InvestigatorOngoing

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Molecular mechanism of overeating regulated by cellular stress responsePrincipal Investigator

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異常タンパク質インターフェイスとしての天然変性領域の機能解析Principal Investigator

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Physiological and Pathological Function of Cellular Stress ResponsesPrincipal Investigator

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「天然」変性タンパク質による「非天然」変性タンパク質の感知・認識機構の解析Principal Investigator

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Identification of novel ER stress responsive pathways that function in intercellular interactionPrincipal Investigator

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小胞体ストレス細胞死における分子制御機構の解明Principal Investigator

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[Journal Article] Correlation between attenuation of protein disulfide isomerase activity through S-mercuration and neurotoxicity induced by methylmercury2015

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[Journal Article] Membrane lipidsaturation activates IRE1α without clustering2015

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[Journal Article] A role for regulated IRE-1 dependent decay in curtailing immunoglobulin secretion from plasma cells2014

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[Journal Article] Evaluating experimental cerebral malaria using oxidative stress indicator OKD48 mice2014

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[Journal Article] Inositol-requiring enzyme 1-α regulates CD8α+ dendritic cell function via regulated mRNA decay2014

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[Journal Article] Temporal activation of Nrf2 in the penumbra and Nrf2 activator-mediated neuroprotection in ischemia-reperfusion injury.2014

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[Journal Article] Protection afforded by pre- or post-treatment with 4-phenylbutyrate against liver injury induced by acetaminophen overdose in mice.2014

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IWAWAKI Takao 岩脇隆夫