Iwawaki Takao 岩脇隆夫

… Alternative Names

IWAWAKI Takao 岩脇隆夫

岩脇隆夫イワワキタカオ

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Researcher Number	50342754
Other IDs
Affiliation (Current)	2025: 金沢医科大学, 総合医学研究所, 教授
Affiliation (based on the past Project Information) *help	2018 – 2024: 金沢医科大学, 総合医学研究所, 教授 2016: 金沢医科大学, 総合医学研究所, 教授 2015: 群馬大学, 医学(系)研究科(研究院), 講師 2011 – 2014: 群馬大学, 先端科学研究指導者育成ユニット, 講師 2010: The Institute of Physical and Chemical Research, 中野生体膜研究室, 客員主管研究員 … More 2009: The Institute of Physical and Chemical Research, 岩脇独立主幹研究ユニット, ユニットリーダー(独立主幹研究員) 2003: 理研, 研究員 2002: 理化学研究所, 細胞修復機構研究チーム, 基礎科学特別研究員 Less
Review Section/Research Field	Principal Investigator Basic Section 59020:Sports sciences-related / Biological Sciences / General physiology / Medium-sized Section 59:Sports sciences, physical education, health sciences, and related fields / Basic Section 42040:Laboratory animal science-related / Environmental physiology(including physical medicine and nutritional physiology) / Neurochemistry/Neuropharmacology Except Principal Investigator Basic Section 49060:Virology-related / Basic Section 58020:Hygiene and public health-related: including laboratory approach
Keywords	Principal Investigator 小胞体ストレス / 細胞ストレス / 炎症 / タンパク質品質管理 / ストレス / 運動 / 睡眠 / 疲労 / 生体イメージング / IRE1 … More / 疾患 / 老化 / マウスモデル / ミトコンドリア / 老化モデル / 疾患モデル / 過食 / エリスロポエチン / ATF4 / ムチン / 癌 / 炎症性腸疾患 / ガン / 脂質代謝 / 酸化ストレス / 天然変性タンパク質 / 分子シャペロン / ＰＥＲＫ / ＩＲＥ１ / 異常タンパク質 / RNase / 小胞体シャペロン / 妊娠 / RNA / 動脈硬化 / 抗体産生 / インスリン / 小胞体ストレス応答 / 唾液腺 / 糖尿病 / 膵臓 / 胎盤 / 血管新生 / トランスジェニックマウス / XBP1 / GFP … More Except Principal Investigator 毛周期 / 間質性腎炎 / 腎糸球体 / 小胞体ストレス応答 / 急性肝細胞壊死 / エピゲノム / 母体免疫亢進 / 感染 / 虐待 / 育児放棄 / 脳 / マウス / 小胞体ストレス Less

Functional analysis of endoplasmic reticulum stress disorders in the brain with a view to therapeutic interventions for inappropriate parenting
- Principal Investigator
  
  田中貴士
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 58020:Hygiene and public health-related: including laboratory approach
- Research Institution
  Kumamoto Health Science University
疲労時に活性化する細胞ストレス応答の生体保護的な役割を解明するためにPrincipal Investigator
- Principal Investigator
  
  岩脇隆夫
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 59020:Sports sciences-related
- Research Institution
  Kanazawa Medical University
Mechanisms of Acute Hepatocellular Necrosis Caused by Prenatal Exposure to Maternal Inflammation
- Principal Investigator
  
  八田稔久
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 49060:Virology-related
- Research Institution
  Kanazawa Medical University
ミトコンドリアで生じる早期の機能的ストレスを可視化するモデルマウス開発Principal Investigator
- Principal Investigator
  
  岩脇隆夫
- Project Period (FY)
  2023 – 2024
- Research Category
  
  Grant-in-Aid for Challenging Research (Exploratory)
- Review Section
  
  Medium-sized Section 59:Sports sciences, physical education, health sciences, and related fields
- Research Institution
  Kanazawa Medical University
Molecular Cell Biology of Fatigue Mechanisms Approached from Developmental Studies of Cellular Stress and InflammationPrincipal Investigator
- Principal Investigator
  
  IWAWAKI Takao
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 59020:Sports sciences-related
- Research Institution
  Kanazawa Medical University
Transgenic mice for imaging of cellular stress associated with diseases and agingPrincipal Investigator
- Principal Investigator
  
  IWAWAKI Takao
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 42040:Laboratory animal science-related
- Research Institution
  Kanazawa Medical University
Molecular mechanism of overeating regulated by cellular stress responsePrincipal Investigator
- Principal Investigator
  
  IWAWAKI Takao
- Project Period (FY)
  2015 – 2016
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Environmental physiology(including physical medicine and nutritional physiology)
- Research Institution
  Kanazawa Medical University
  Gunma University
異常タンパク質インターフェイスとしての天然変性領域の機能解析Principal Investigator
- Principal Investigator
  
  岩脇隆夫
- Project Period (FY)
  2012 – 2013
- Research Category
  
  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
- Review Section
  
  Biological Sciences
- Research Institution
  Gunma University
Physiological and Pathological Function of Cellular Stress ResponsesPrincipal Investigator
- Principal Investigator
  
  IWAWAKI Takao
- Project Period (FY)
  2012 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  General physiology
- Research Institution
  Gunma University
「天然」変性タンパク質による「非天然」変性タンパク質の感知・認識機構の解析Principal Investigator
- Principal Investigator
  
  岩脇隆夫
- Project Period (FY)
  2010 – 2011
- Research Category
  
  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
- Review Section
  
  Biological Sciences
- Research Institution
  Gunma University
  The Institute of Physical and Chemical Research
Identification of novel ER stress responsive pathways that function in intercellular interactionPrincipal Investigator
- Principal Investigator
  
  IWAWAKI Takao
- Project Period (FY)
  2009 – 2010
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  General physiology
- Research Institution
  The Institute of Physical and Chemical Research
小胞体ストレス細胞死における分子制御機構の解明Principal Investigator
- Principal Investigator
  
  岩脇隆夫
- Project Period (FY)
  2002 – 2003
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Neurochemistry/Neuropharmacology
- Research Institution
  The Institute of Physical and Chemical Research

[Journal Article] Unconventional Activation of IRE1 Enhances TH17 Responses and Promotes Airway Neutrophilia2024
- Author(s)
  Wu Dandan、Zhang Xing、Zimmerly Kourtney M.、Wang Ruoning、Livingston Amanda、Iwawaki Takao、Kumar Ashok、Wu Xiang、Campen Matthew、Mandell Michael A.、Liu Meilian、Yang Xuexian O.
- Journal Title
  
  American Journal of Respiratory Cell and Molecular Biology
  
  Volume: - Issue: 2 Pages: 169-181
- DOI
  10.1165/rcmb.2023-0424oc
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-23K27421
[Journal Article] A stress sensor, IRE1α, is required for bacterial-exotoxin-induced interleukin-1β production in tissue-resident macrophages2024
- Author(s)
  I. Sasaki, Y. Fukuda-Ohta, C. Nakai, N. Wakaki-Nishiyama, C. Okamoto, D. Okuzaki, S. Morita, S. Kaji, Y. Furuta, H. Hemmi, T. Kato, A. Yamamoto, E. Tosuji, SI Saitoh, T. Tanaka, K. Hoshino, S. Fukuda, K. Miyake, E. Kuroda, KJ Ishii, T. Iwawaki, K. Furukawa, T. Kaisho.
- Journal Title
  
  Cell Reports
  
  Volume: 43 Issue: 4 Pages: 113981-113981
- DOI
  10.1016/j.celrep.2024.113981
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-23K18222, KAKENHI-PROJECT-23K19487, KAKENHI-PROJECT-22K07006, KAKENHI-PROJECT-22K19424, KAKENHI-PLANNED-22H05184, KAKENHI-PLANNED-22H05187, KAKENHI-PROJECT-21H04800, KAKENHI-PROJECT-23K27421
[Journal Article] Keratinocyte-Specific SOX2 Overexpression Suppressed Pressure Ulcer Formation after Cutaneous Ischemia?Reperfusion Injury via?Enhancement of Amphiregulin Production2024
- Author(s)
  Inoue Yuta、Uchiyama Akihiko、Amalia Syahla Nisaa、Ishikawa Mai、Kosaka Keiji、Sekiguchi Akiko、Ogino Sachiko、Yokoyama Yoko、Torii Ryoko、Hosoi Mari、Akai Ryoko、Iwawaki Takao、Morasso Maria I.、Motegi Sei-ichiro
- Journal Title
  
  Journal of Investigative Dermatology
  
  Volume: 144 Issue: 1 Pages: 142-151.e5
- DOI
  10.1016/j.jid.2023.06.202
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-23K27421
[Journal Article] Partial limitation of cellular functions and compensatory modulation of unfolded protein response pathways caused by double-knockout of ATF6α and ATF6β2024
- Author(s)
  Akai R, Hamashima H, Saito M, Kohno K, Iwawaki T
- Journal Title
  
  Cell Stress Chaperones
  
  Volume: 29 Issue: 1 Pages: 34-48
- DOI
  10.1016/j.cstres.2023.11.002
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K08219, KAKENHI-PROJECT-21H03334, KAKENHI-PROJECT-23K27421
[Journal Article] Inflammatory ER stress responses dictate the immunopathogenic progression of systemic candidiasis2023
- Author(s)
  Awasthi D, Chopra S, Cho BA, Emmanuelli A, Sandoval TA, Hwang SM, Chae CS, Salvagno C, Tan C, Vasquez-Urbina L, Fernandez Rodriguez JJ, Santagostino SF, Iwawaki T, Romero-Sandoval EA, Crespo MS, Morales DK, Iliev ID, Hohl TM, Cubillos-Ruiz JR
- Journal Title
  
  J Clin Invest
  
  Volume: 133 Issue: 17
- DOI
  10.1172/jci167359
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21H03334, KAKENHI-PROJECT-23K27421
[Journal Article] Deletion of the Unfolded Protein Response Transducer IRE1α Is Detrimental to Aging Photoreceptors and to ER Stress-Mediated Retinal Degeneration2023
- Author(s)
  Massoudi D, Gorman S, Kuo YM, Iwawaki T, Oakes SA, Papa FR, Gould DB
- Journal Title
  
  Invest Ophthalmol Vis Sci
  
  Volume: 64 Issue: 4 Pages: 30-30
- DOI
  10.1167/iovs.64.4.30
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21H03334, KAKENHI-PROJECT-23K27421
[Journal Article] Dynamic change and preventive role of stress response via Keap1-Nrf2 during renal crystal formation2023
- Author(s)
  Ushimoto C, Sugiki S, Kunii K, Inoue S, Kuroda E, Akai R, Iwawaki T, Miyazawa K
- Journal Title
  
  Free Radic Biol Med
  
  Volume: 207 Pages: 120-132
- DOI
  10.1016/j.freeradbiomed.2023.07.013
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21H03334, KAKENHI-PROJECT-23K27421
[Journal Article] Nuanced role for dendritic cell intrinsic IRE1 RNase in the regulation of antitumor adaptive immunity2023
- Author(s)
  Flores-Santibanez F, Rennen S, Fernandez D, De Nolf C, Van De Velde E, Gaete Gonzalez S, Fuentes C, Moreno C, Figueroa D, Lladser A, Iwawaki T, Bono MR, Janssens S, Osorio F
- Journal Title
  
  Front Immunol
  
  Volume: 14 Pages: 1209588-1209588
- DOI
  10.3389/fimmu.2023.1209588
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21H03334, KAKENHI-PROJECT-23K27421
[Journal Article] ERdj5 protects goblet cells from endoplasmic reticulum stress-mediated apoptosis under inflammatory conditions2023
- Author(s)
  Jeong H, Hong EH, Ahn JH, Cho J, Jeong JH, Kim CW, Yoon BI, Koo JH, Park YY, Yang YM, Iwawaki T, Vallance BA, Chang SY, Ko HJ
- Journal Title
  
  Exp Mol Med
  
  Volume: 55 Issue: 2 Pages: 401-412
- DOI
  10.1038/s12276-023-00945-x
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21H03334, KAKENHI-PROJECT-23K27421
[Journal Article] The Unfolded Protein Response Sensor IRE1 Regulates Activation of In Vitro Differentiated Type 1 Conventional DCs with Viral Stimuli2023
- Author(s)
  Medel B, Bernales JI, Lira A, Fernandez D, Iwawaki T, Vargas P, Osorio F
- Journal Title
  
  Int J Mol Sci
  
  Volume: 24 Issue: 12 Pages: 10205-10205
- DOI
  10.3390/ijms241210205
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21H03334, KAKENHI-PROJECT-23K27421
[Journal Article] 疲労を考える上で関心を向けざるを得ない細胞ストレス応答の分子メカニズム2022
- Author(s)
  黒田絵莉子, 赤井良子, 岩脇隆夫
- Journal Title
  
  日本疲労学会誌
  
  Volume: 16 Pages: 9-15
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21H03334
[Journal Article] Salmonella Exhibit Altered Cellular Localization in the Presence of HLA-B27 and Codistribute with Endo-Reticular Membrane2022
- Author(s)
  Kriston-Vizi Janos、Lenart Izabela、Iwawaki Takao、Gould Keith、Nesbeth Darren、Powis Simon J.、Antoniou Antony N.
- Journal Title
  
  Journal of Immunology Research
  
  Volume: 2022 Pages: 9493019-9493019
- DOI
  10.1155/2022/9493019
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21H03334
[Journal Article] The unfolded protein response transducer IRE1α promotes reticulophagy in podocytes2022
- Author(s)
  Navarro-Betancourt Jos? R.、Papillon Joan、Guillemette Julie、Chung Chen-Fang、Iwawaki Takao、Cybulsky Andrey V.
- Journal Title
  
  Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease
  
  Volume: 1868 Issue: 6 Pages: 166391-166391
- DOI
  10.1016/j.bbadis.2022.166391
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21H03334
[Journal Article] Targeting IRE1 endoribonuclease activity alleviates cardiovascular lesions in a murine model of Kawasaki disease vasculitis2022
- Author(s)
  Marek-Iannucci Stefanie、Yildirim Asli D.、Hamid Syed M.、Ozdemir Asli B.、Gomez Angela C.、Kocat?rk Beg?m、Porritt Rebecca A.、Fishbein Michael C.、Iwawaki Takao、Noval Rivas Magali、Erbay Ebru、Arditi Moshe
- Journal Title
  
  JCI Insight
  
  Volume: 7 Issue: 6
- DOI
  10.1172/jci.insight.157203
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21H03334
[Journal Article] Intercepting IRE1 kinase‐FMRP signaling prevents atherosclerosis progression2022
- Author(s)
  Yildirim Zehra、Baboo Sabyasachi、Hamid Syed M、Dogan Asli E、Tufanli Ozlem、Robichaud Sabrina、Emerton Christina、Diedrich Jolene K、Vatandaslar Hasan、Nikolos Fotis、Gu Yanghong、Iwawaki Takao、Tarling Elizabeth、Ouimet Mireille、Nelson David L、Yates John R、Walter Peter、Erbay Ebru
- Journal Title
  
  EMBO Molecular Medicine
  
  Volume: 14 Issue: 4
- DOI
  10.15252/emmm.202115344
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21H03334
[Journal Article] Mechanisms of liver injury in high fat sugar diet fed mice that lack hepatocyte X-box binding protein 12022
- Author(s)
  Liu Xiaoying、Taylor Sarah A.、Gromer Kyle D.、Zhang Danny、Hubchak Susan C.、LeCuyer Brian E.、Iwawaki Takao、Shi Zengdun、Rockey Don C.、Green Richard M.
- Journal Title
  
  PLOS ONE
  
  Volume: 17 Issue: 1 Pages: e0261789-e0261789
- DOI
  10.1371/journal.pone.0261789
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21H03334
[Journal Article] Alterations in UPR Signaling by Methylmercury Trigger Neuronal Cell Death in the Mouse Brain2022
- Author(s)
  Nomura Ryosuke、Takasugi Nobumasa、Hiraoka Hideki、Iijima Yuta、Iwawaki Takao、Kumagai Yoshito、Fujimura Masatake、Uehara Takashi
- Journal Title
  
  International Journal of Molecular Sciences
  
  Volume: 23 Issue: 23 Pages: 15412-15412
- DOI
  10.3390/ijms232315412
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18H05293, KAKENHI-PROJECT-21H03334, KAKENHI-PROJECT-20K07014
[Journal Article] Inhibition of skin fibrosis in systemic sclerosis by botulinum toxin B via the suppression of oxidative stress2021
- Author(s)
  Baral H, Sekiguchi A, Uchiyama A, Nisaa Amalia S, Yamazaki S, Inoue Y, Yokoyama Y, Ogino S, Torii R, Hosoi M, Akai R, Iwawaki T, Ishikawa O, Motegi SI
- Journal Title
  
  J Dermatol Sci
  
  Volume: 48 Issue: 7 Pages: 1052-1061
- DOI
  10.1111/1346-8138.15888
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21H03334
[Journal Article] The IRE1/XBP1 signaling axis promotes skeletal muscle regeneration through a cell non-autonomous mechanism2021
- Author(s)
  Roy A, Tomaz da Silva M, Bhat R, Bohnert KR, Iwawaki T, Kumar A
- Journal Title
  
  Elife
  
  Volume: 10
- DOI
  10.7554/elife.73215
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21H03334
[Journal Article] Hepatocyte-specific deletion of XBP1 sensitizes mice to liver injury through hyperactivation of IRE1α2021
- Author(s)
  Duwaerts CC, Siao K, Soon RK Jr, Her C, Iwawaki T, Kohno K, Mattis AN, Maher JJ
- Journal Title
  
  Cell Death Differ
  
  Volume: 28 Issue: 5 Pages: 1455-1465
- DOI
  10.1038/s41418-020-00671-1
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21H03334
[Journal Article] Spatiotemporal analysis of the UPR transition induced by methylmercury in the mouse brain.2021
- Author(s)
  Hiraoka, H., Nomura, R., Takasugi, N., Akai, R., Iwawaki, T., Kumagai, Y., Fujimura, M., and Uehara, T.
- Journal Title
  
  Arch. Toxicol.
  
  Volume: 95 Issue: 4 Pages: 1241-1250
- DOI
  10.1007/s00204-021-02982-9
- NAID
  120007185542
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18H02579, KAKENHI-PROJECT-20J11445, KAKENHI-PROJECT-19K22498, KAKENHI-PROJECT-18H05293, KAKENHI-PROJECT-21H03334, KAKENHI-PROJECT-20K07014
[Journal Article] IRE1α regulates macrophage polarization, PD-L1 expression, and tumor survival2020
- Author(s)
  Batista Alyssa、Rodvold Jeffrey J.、Xian Su、Searles Stephen C.、Lew Alyssa、Iwawaki Takao、Almanza Gonzalo、Waller T. Cameron、Lin Jonathan、Jepsen Kristen、Carter Hannah、Zanetti Maurizio
- Journal Title
  
  PLOS Biology
  
  Volume: 18 Issue: 6 Pages: e3000687-e3000687
- DOI
  10.1371/journal.pbio.3000687
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18H02366
[Journal Article] AAV-mediated ERdj5 overexpression protects against P23H rhodopsin toxicity2020
- Author(s)
  Aguila Monica、Bellingham James、Athanasiou Dimitra、Bevilacqua Dalila、Duran Yanai、Maswood Ryea、Parfitt David A、Iwawaki Takao、Spyrou Giannis、Smith Alexander J、Ali Robin R、Cheetham Michael E
- Journal Title
  
  Human Molecular Genetics
  
  Volume: 29 Issue: 8 Pages: 1310-1318
- DOI
  10.1093/hmg/ddaa049
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18H02366
[Journal Article] Transgenic mouse model exhibiting weak red fluorescence before and strong green fluorescence after Cre/loxP-mediated recombination2020
- Author(s)
  Akai Ryoko、Saito Michiko、Kohno Kenji、Iwawaki Takao
- Journal Title
  
  Experimental Animals
  
  Volume: 69 Issue: 3 Pages: 306-318
- DOI
  10.1538/expanim.19-0085
- NAID
  130007884759
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18H02366
[Journal Article] IRE1α Promotes Zika Virus Infection via XBP12020
- Author(s)
  Kolpikova Elena P.、Tronco Ana R.、Den Hartigh Andreas B.、Jackson Konner J.、Iwawaki Takao、Fink Susan L.
- Journal Title
  
  Viruses
  
  Volume: 12 Issue: 3 Pages: 278-278
- DOI
  10.3390/v12030278
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18H02366
[Journal Article] Protective effect of dimethyl fumarate for the development of pressure ulcers after cutaneous ischemia‐reperfusion injury2020
- Author(s)
  Inoue Yuta、Uchiyama Akihiko、Sekiguchi Akiko、Yamazaki Sahori、Fujiwara Chisako、Yokoyama Yoko、Ogino Sachiko、Torii Ryoko、Hosoi Mari、Akai Ryoko、Iwawaki Takao、Ishikawa Osamu、Motegi Sei‐ichiro
- Journal Title
  
  Wound Repair and Regeneration
  
  Volume: 28 Issue: 5 Pages: 600-608
- DOI
  10.1111/wrr.12824
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18H02366
[Journal Article] Protein quality control through endoplasmic reticulum-associated degradation maintains haematopoietic stem cell identity and niche interactions2020
- Author(s)
  Xu Longyong、Iwawaki Takao、Chen Xi et al
- Journal Title
  
  Nature Cell Biology
  
  Volume: 22 Issue: 10 Pages: 1162-1169
- DOI
  10.1038/s41556-020-00581-x
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18H02366
[Journal Article] Apelin/APJ signaling suppresses the pressure ulcer formation in cutaneous ischemia-reperfusion injury mouse model2020
- Author(s)
  Yamazaki Sahori、Sekiguchi Akiko、Uchiyama Akihiko、Fujiwara Chisako、Inoue Yuta、Yokoyama Yoko、Ogino Sachiko、Torii Ryoko、Hosoi Mari、Akai Ryoko、Iwawaki Takao、Ishikawa Osamu、Motegi Sei-ichiro
- Journal Title
  
  Scientific Reports
  
  Volume: 10 Issue: 1 Pages: 1349-1349
- DOI
  10.1038/s41598-020-58452-2
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18H02366
[Journal Article] Role of IRE1α in podocyte proteostasis and mitochondrial health2020
- Author(s)
  Navarro-Betancourt Jos? R.、Papillon Joan、Guillemette Julie、Iwawaki Takao、Chung Chen-Fang、Cybulsky Andrey V.
- Journal Title
  
  Cell Death Discovery
  
  Volume: 6 Issue: 1 Pages: 128-128
- DOI
  10.1038/s41420-020-00361-4
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18H02366
[Journal Article] ERdj5 in Innate Immune Cells Is a Crucial Factor for the Mucosal Adjuvanticity of Cholera Toxin2019
- Author(s)
  Kim MS, Yi EJ, Kim YI, Kim SH, Jung YS, Kim SR, Iwawaki T, Ko HJ, Chang SY
- Journal Title
  
  Front Immunol
  
  Volume: 10 Pages: 1249-1249
- DOI
  10.3389/fimmu.2019.01249
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18H02366
[Journal Article] Zinc deficiency exacerbates pressure ulcers by increasing oxidative stress and ATP in the skin2019
- Author(s)
  Nakamura H, Sekiguchi A, Ogawa Y, Kawamura T, Akai R, Iwawaki T, Makiguchi T, Yokoo S, Ishikawa O, Motegi SI
- Journal Title
  
  J Dermatol Sci
  
  Volume: 95 Issue: 2 Pages: 62-69
- DOI
  10.1016/j.jdermsci.2019.07.004
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18H02366, KAKENHI-PROJECT-19K21517
[Journal Article] Adaptive endoplasmic reticulum stress signalling via IRE1α-XBP1 preserves self-renewal of haematopoietic and pre-leukaemic stem cells2019
- Author(s)
  Liu L, Zhao M, Jin X, Ney G, Yang KB, Peng F, Cao J, Iwawaki T, Del Valle J, Chen X, Li Q
- Journal Title
  
  Nat Cell Biol
  
  Volume: 21 Issue: 3 Pages: 328-337
- DOI
  10.1038/s41556-019-0285-6
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18H02366
[Journal Article] Salmonella exploits HLA-B27 and host unfolded protein responses to promote intracellular replication2019
- Author(s)
  Antoniou AN, Lenart I, Kriston-Vizi J, Iwawaki T, Turmaine M, McHugh K, Ali S, Blake N, Bowness P, Bajaj-Elliott M, Gould K, Nesbeth D, Powis SJ
- Journal Title
  
  Ann Rheum Dis
  
  Volume: 78 Issue: 1 Pages: 74-82
- DOI
  10.1136/annrheumdis-2018-213532
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18H02366
[Journal Article] IRE1α-XBP1 signaling in leukocytes controls prostaglandin biosynthesis and pain2019
- Author(s)
  Chopra S, Giovanelli P, Alvarado-Vazquez PA, Alonso S, Song M, Sandoval TA, Chae CS, Tan C, Fonseca MM, Gutierrez S, Jimenez L, Subbaramaiah K, Iwawaki T, Kingsley PJ, Marnett LJ, Kossenkov AV, Crespo MS, Dannenberg AJ, Glimcher LH, Romero-Sandoval EA, Cubillos-Ruiz JR
- Journal Title
  
  Science
  
  Volume: 365 Issue: 6450
- DOI
  10.1126/science.aau6499
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18H02366
[Journal Article] IRE1α Activation in Bone Marrow-Derived Dendritic Cells Modulates Innate Recognition of Melanoma Cells and Favors CD8+ T Cell Priming2019
- Author(s)
  Medel B, Costoya C, Fernandez D, Pereda C, Lladser A, Sauma D, Pacheco R, Iwawaki T, Salazar-Onfray F, Osorio F
- Journal Title
  
  Front Immunol
  
  Volume: 9 Pages: 3050-3050
- DOI
  10.3389/fimmu.2018.03050
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18H02366
[Journal Article] Danger-associated extracellular ATP counters MDSC therapeutic efficacy in acute GVHD2019
- Author(s)
  Koehn BH, Saha A, McDonald-Hyman C, Loschi M, Thangavelu G, Ma L, Zaiken M, Dysthe J, Krepps W, Panthera J, Hippen K, Jameson SC, Miller JS, Cooper MA, Farady CJ, Iwawaki T, Ting JP, Serody JS, Murphy WJ, Hill GR, Murray PJ, Bronte V, Munn DH, Zeiser R, Blazar BR
- Journal Title
  
  Blood
  
  Volume: 134 Issue: 19 Pages: 1670-1682
- DOI
  10.1182/blood.2019001950
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18H02366
[Journal Article] MITOL prevemts ER stress-induced apoptosis by IRE1 ubiquitylation at mitochondrial-ER contact sites.2019
- Author(s)
  Takeda, K., Nagashima, S., Shiiba, I., Uda, A., Tokuyama, T., Ito, N., Fukuda, T., Matsushita, N., Ishido, S., Iwawaki, T., Uehara, T., Inatome, R., and Yanagi, S.
- Journal Title
  
  EMBO J.
  
  Volume: 38 Issue: 15
- DOI
  10.15252/embj.2018100999
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K22498, KAKENHI-PUBLICLY-18H04869, KAKENHI-PROJECT-17H04053, KAKENHI-PROJECT-18H02366, KAKENHI-PROJECT-18H02579, KAKENHI-PROJECT-17K08793, KAKENHI-PROJECT-19K16527
[Journal Article] Ablation of the Chaperone Protein ERdj5 Results in a Sjogren's Syndrome-Like Phenotype in Mice, Consistent With an Upregulated Unfolded Protein Response in Human Patients2019
- Author(s)
  Apostolou E, Moustardas P, Iwawaki T, Tzioufas AG, Spyrou G
- Journal Title
  
  Front Immunol
  
  Volume: 10 Pages: 506-506
- DOI
  10.3389/fimmu.2019.00506
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18H02366
[Journal Article] Molecular Mechanism of Cellular Oxidative Stress Sensing by Keap12019
- Author(s)
  Suzuki Takafumi、Muramatsu Aki、Saito Ryota、Iso Tatsuro、Shibata Takahiro、Kuwata Keiko、Kawaguchi Shin-ichi、Iwawaki Takao、Adachi Saki、Suda Hiromi、Morita Masanobu、Uchida Koji、Baird Liam、Yamamoto Masayuki
- Journal Title
  
  Cell Reports
  
  Volume: 28 Issue: 3 Pages: 746-758
- DOI
  10.1016/j.celrep.2019.06.047
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K07340, KAKENHI-PROJECT-19K07341, KAKENHI-PROJECT-17KK0183, KAKENHI-PUBLICLY-18H04963, KAKENHI-PROJECT-19H05649, KAKENHI-PROJECT-19H00990, KAKENHI-PROJECT-19H01019, KAKENHI-PROJECT-18H02366, KAKENHI-PROJECT-18K19417, KAKENHI-PROJECT-17H06170, KAKENHI-ORGANIZER-15H05935
[Journal Article] Inhibitory effect of kaempferol on skin fibrosis in systemic sclerosis by the suppression of oxidative stress2019
- Author(s)
  Sekiguchi A, Motegi SI, Fujiwara C, Yamazaki S, Inoue Y, Uchiyama A, Akai R, Iwawaki T, Ishikawa O
- Journal Title
  
  J Dermatol Sci
  
  Volume: 96 Issue: 1 Pages: 8-17
- DOI
  10.1016/j.jdermsci.2019.08.004
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18H02366, KAKENHI-PROJECT-19K21517
[Journal Article] IRE1-XBP1 pathway regulates oxidative proinsulin folding in pancreatic β cells2018
- Author(s)
  Yuichi Tsuchiya, Michiko Saito, Hiroshi Kadokura, Jun-ichi Miyazaki, Fumi Tashiro, Yusuke Imagawa, Takao Iwawaki, Kenji Kohno
- Journal Title
  
  The Journal of Cell Biology
  
  Volume: 217 Issue: 4 Pages: 1287-1301
- DOI
  10.1083/jcb.201707143
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15K07381, KAKENHI-PROJECT-24228002, KAKENHI-PLANNED-26116006, KAKENHI-PUBLICLY-18H05047, KAKENHI-PROJECT-17H01468, KAKENHI-PROJECT-18H02366, KAKENHI-PROJECT-17K15134, KAKENHI-PLANNED-26116005
[Journal Article] タンパク質恒常性と糖代謝異常に関わる小胞体ストレス応答の役割2018
- Author(s)
  岩脇隆夫
- Journal Title
  
  金沢医科大学雑誌
  
  Volume: 43 Pages: 15-22
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18H02366
[Journal Article] 小胞体ストレスの生体イメージング2018
- Author(s)
  岩脇隆夫, 赤井良子
- Journal Title
  
  THE BONE
  
  Volume: 32 Pages: 171-177
- Data Source
  KAKENHI-PROJECT-18H02366
[Journal Article] ERα promotes murine hematopoietic regeneration through the Ire1α-mediated unfolded protein response2018
- Author(s)
  Chapple RH, Hu T, Tseng YJ, Liu L, Kitano A, Luu V, Hoegenauer KA, Iwawaki T, Li Q, Nakada D
- Journal Title
  
  eLife
  
  Volume: 7
- DOI
  10.7554/elife.31159
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18H02366
[Journal Article] IRE1α governs cytoskeleton remodelling and cell migration through a direct interaction with filamin A2018
- Author(s)
  Urra H, Henriquez DR, Canovas J, Villarroel-Campos D, Carreras-Sureda A, Pulgar E, Molina E, Hazari YM, Limia CM, Alvarez-Rojas S, Figueroa R, Vidal RL, Rodriguez DA, Rivera CA, Court FA, Couve A, Qi L, Chevet E, Akai R, Iwawaki T, Concha ML, Glavic A, Gonzalez-Billault C, Hetz C
- Journal Title
  
  Nature Cell Biology
  
  Volume: 20 Issue: 8 Pages: 942-953
- DOI
  10.1038/s41556-018-0141-0
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18H02366, KAKENHI-PROJECT-19K21517
[Journal Article] Botulinum toxin B suppresses the pressure ulcer formation in cutaneous ischemia-reperfusion injury mouse model: Possible regulation of oxidative and endoplasmic reticulum stress2018
- Author(s)
  Sekiguchi A, Motegi SI, Uchiyama A, Uehara A, Fujiwara C, Yamazaki S, Perera B, Nakamura H, Ogino S, Yokoyama Y, Akai R, Iwawaki T, Ishikawa O
- Journal Title
  
  Journal of Dermatological Science
  
  Volume: 90 Issue: 2 Pages: 144-153
- DOI
  10.1016/j.jdermsci.2018.01.006
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18H02366, KAKENHI-PROJECT-19K21517
[Journal Article] Activation of Host IRE1α-Dependent Signaling Axis Contributes the Intracellular Parasitism of Brucella melitensis2018
- Author(s)
  Pandey A, Lin F, Cabello AL, da Costa LF, Feng X, Feng HQ, Zhang MZ, Iwawaki T, Rice-Ficht A, Ficht TA, de Figueiredo P, Qin QM
- Journal Title
  
  Frontiers in Cellular and Infection Microbiology
  
  Volume: 8 Pages: 103-103
- DOI
  10.3389/fcimb.2018.00103
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18H02366
[Journal Article] Stabilization of cytokine mRNAs in iNKT cells requires the serine-threonine?kinase IRE1alpha2018
- Author(s)
  Govindarajan S, Gaublomme D, Van der Cruyssen R, Verheugen E, Van Gassen S, Saeys Y, Tavernier S, Iwawaki T, Bloch Y, Savvides SN, Lambrecht BN, Janssens S, Elewaut D, Drennan MB
- Journal Title
  
  Nature Communications
  
  Volume: 9 Issue: 1 Pages: 5340-5340
- DOI
  10.1038/s41467-018-07758-x
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18H02366
[Journal Article] Correlation Between Attenuation of Protein Disulfide Isomerase Activity Through S-Mercuration and Neurotoxicity Induced by Methylmercury.2015
- Author(s)
  Makino K, Okuda K, Sugino E, Nishiya T, Toyama T, Iwawaki T, Fujimura M, Kumagai Y, Uehara T.
- Journal Title
  
  Neurotox Res
  
  Volume: 27 Issue: 2 Pages: 99-105
- DOI
  10.1007/s12640-014-9494-8
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-12J03394, KAKENHI-PROJECT-24390049, KAKENHI-PROJECT-25220103, KAKENHI-PROJECT-25670029, KAKENHI-PLANNED-26111008, KAKENHI-PROJECT-26460068
[Journal Article] Protection afforded by pre- or post-treatment with 4-phenylbutyrateagainst liver injury induced by acetaminophen overdose in mice2014
- Author(s)
  Daisuke Shimizua, Yoichi Ishitsuka, Keishi Miyata, Yoshiro Tomishima, Yuki Kondo, Mitsuru Irikura, Takao Iwawaki, Yuichi Oike, Tetsumi Irie
- Journal Title
  
  Pharmacol. Res.
  
  Volume: 87 Pages: 26-41
- DOI
  10.1016/j.phrs.2014.06.003
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24390049, KAKENHI-PROJECT-25461114, KAKENHI-PUBLICLY-26116722, KAKENHI-PROJECT-26293190, KAKENHI-PROJECT-26670405
[Journal Article] Evaluating experimental cerebral malaria using oxidative stress indicator OKD48 mice.2014
- Author(s)
  Imai T, Iwawaki T, Akai R, Suzue K, Hirai M, Taniguchi T, Okada H, Hisaeda H.
- Journal Title
  
  Int J Parasitol.
  
  Volume: 44 Issue: 10 Pages: 681-685
- DOI
  10.1016/j.ijpara.2014.06.002
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PUBLICLY-24112705, KAKENHI-PROJECT-24390049, KAKENHI-PROJECT-24590501, KAKENHI-PROJECT-25670226, KAKENHI-PROJECT-26860276, KAKENHI-PROJECT-26870094
[Journal Article] Temporal activation of Nrf2 in the penumbra and Nrf2 activator-mediated neuroprotection in ischemia-reperfusionin jury2014
- Author(s)
  Toshinori Takagi, Akira Kitashoji, Takao Iwawaki, Kazuhiro Tsuruma, Masamitsu Shimazawa, Shinichi Yoshimura, Toru Iwama, Hideaki Hara
- Journal Title
  
  Free Radic. Biol. Med.
  
  Volume: 72 Pages: 124-133
- DOI
  10.1016/j.freeradbiomed.2014.04.009
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-24390049, KAKENHI-PROJECT-25861266
[Journal Article] The co-chaperone and reductase ERdj5 facilitates rod opsin biogenesis and quality control2014
- Author(s)
  Dimitra Athanasiou, Dalila Bevilacqua, Monica Aguila, Caroline McCulley, Naheed Kanuga, Takao Iwawaki, J. Paul Chapple, Michael E. Cheetham
- Journal Title
  
  Hum. Mol. Genet.
  
  Volume: 23 Issue: 24 Pages: 6594-6606
- DOI
  10.1093/hmg/ddu385
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24390049
[Journal Article] A role for regulated IRE-1 dependent decay in curtailing immunoglobulin secretion from plasma cells2014
- Author(s)
  Sandrine Benhamron, Takao Iwawaki, Jae-Seon So, Ann-Hwee Lee, Boaz Tirosh
- Journal Title
  
  Eur. J. Immunol.
  
  Volume: 44 Issue: 3 Pages: 867-876
- DOI
  10.1002/eji.201343953
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24390049
[Journal Article] Inositol-requiring enzyme 1-α regulates CD8α+ dendritic cell function via regulated mRNA decay2014
- Author(s)
  Fabiola Osorio, Simon Tavernier, Eik Hoffmann, Yvan Saeys, Liesbet Martens, Jessica Vetters, Iris Delrue, Riet De Rycke, Eef Parthoens, Philippe Poulliot, Takao Iwawaki, Sophie Janssens, Bart N. Lambrecht
- Journal Title
  
  Nat. Immunol.
  
  Volume: 15 Issue: 3 Pages: 248-257
- DOI
  10.1038/ni.2808
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24390049
[Journal Article] Comparative analysis of ER stress response into HIV protease inhibitors : Lopinavir but not Darunavir induces potent ER stress response via ROS/JNK pathway.2013
- Author(s)
  Taura M, Kariya R, Kudo E, Goto H, Iwawaki T, Amano M, Suico MA, Kai H, Mitsuya H, Okada S.
- Journal Title
  
  Free Radical Biology and Medicine
  
  Volume: 65 Pages: 778-788
- DOI
  10.1016/j.freeradbiomed.2013.08.161
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-12J08328, KAKENHI-PROJECT-23390265, KAKENHI-PROJECT-24390049
[Journal Article] Paneth cells as a site of origin for intestinal inflammation2013
- Author(s)
  Adolph,T.E.,Tomczak,M.F.,Niederreiter,L.,Ko,H.J.,Bock,J.,Martinez-Naves,E.,Glickman,J.N.,Tschurtschenthaler,M.,Hartwig,J.,Hosomi,S.,Flak,M.B.,Cusick,J.L.,Kohno,K.,Iwawaki,T.,Billmann-Born,S.,Raine,T.,Bharti,R.,Lucius,R.,Kweon,M.N.,Marciniak,S.J.,Choi,A.,Hagen,S.J.,Schreiber,S.,Rosenstiel,P.,Kaser,A.,Blumberg,RS.
- Journal Title
  
  Nature
  
  Volume: 503 Issue: 7475 Pages: 272-276
- DOI
  10.1038/nature12599
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24228002, KAKENHI-PROJECT-24390049
[Journal Article] 小胞体ストレスシグナルの感知・生体防御機構2013
- Author(s)
  岩脇隆夫
- Journal Title
  
  細胞
  
  Volume: 45 Pages: 168-171
- Data Source
  KAKENHI-PROJECT-24390049
[Journal Article] 小胞体ストレスシグナルの感知・生体防御機構2013
- Author(s)
  岩脇　隆夫
- Journal Title
  
  細胞
  
  Volume: 45 Pages: 168-171
- Data Source
  KAKENHI-PUBLICLY-24113702
[Journal Article] 生きているマウスで酸化ストレスを見えるように2013
- Author(s)
  及川大輔、岩脇隆夫
- Journal Title
  
  化学と生物
  
  Volume: 51 Pages: 361-363
- Data Source
  KAKENHI-PROJECT-24390049
[Journal Article] CHOP is a critical regulator of acetaminophen-induced hepatotoxicity2013
- Author(s)
  Dotan Uzi, Liran Barda, Viviana Scaiewicz, Maya Mills, Tobias Mueller, Agueda Gonzalez-Rodriguez, Angela M. Valverde, Takao Iwawaki, Yaakov Nahmias, Ramnik J. Xavier, Raymond T. Chung, Boaz Tirosh, Oren Shibolet
- Journal Title
  
  J. Hepatol.
  
  Volume: 59 Issue: 3 Pages: 495-503
- DOI
  10.1016/j.jhep.2013.04.024
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24390049
[Journal Article] ER stress transcription factor Xbp1 suppresses intestinal tumourigenesis and directs intestinal stem cells.2013
- Author(s)
  Niederreiter, L., Fritz, T. M. J., Adolph, T.E., Krismer, A. M., Offner, F. A., Tschurtschenthaler, M., Flak, M. B., Hosomi, S., Tomczak, M. F., Kaneider, N. C., Sarcevic, E., Kempster, S. L., Raine, T., Esser, D., Rosenstiel, P., Kohno, K., Iwawaki, T., Tilg, H., Blumberg, R. S., and Kaser, A.
- Journal Title
  
  J. Exp. Med.
  
  Volume: 210(10) Issue: 10 Pages: 2041-2056
- DOI
  10.1084/jem.20122341
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24228002, KAKENHI-PROJECT-24390049
[Journal Article] Identification of the redox partners of ERdj5/JPDI, a PDI family member, from an animal tissue.2013
- Author(s)
  Kadokura, H., Saito, M., Tsuru, A., Hosoda, A., Iwawaki, T., Inaba, K., & Kohno, K.
- Journal Title
  
  Biochemical and Biophysical Research Communications
  
  Volume: 440 Issue: 2 Pages: 245-250
- DOI
  10.1016/j.bbrc.2013.09.063
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23500496, KAKENHI-PUBLICLY-24113702, KAKENHI-PROJECT-24228002, KAKENHI-PROJECT-24580141
[Journal Article] MTP inhibition induces ER stress and increases gene transcription via Ire1α/cJun to enhance plasma ALT/AST.2013
- Author(s)
  Josekutty, J., Iqbal, J., Iwawaki, T., Kohno, K., and Hussain, M.
- Journal Title
  
  J. Biol. Chem.
  
  Volume: 288(20) Issue: 20 Pages: 14372-14383
- DOI
  10.1074/jbc.m113.459602
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24228002, KAKENHI-PROJECT-24390049
[Journal Article] The role of the unfolded protein response in diabetes mellitus2013
- Author(s)
  Takao Iwawaki, Daisuke Oikawa
- Journal Title
  
  Semin. Immunopathol.
  
  Volume: 35 Issue: 3 Pages: 333-350
- DOI
  10.1007/s00281-013-0369-5
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24390049
[Journal Article] Positive contribution of IRE1α-XBP1 pathway to the expression of placental cathepsins2013
- Author(s)
  Daisuke Oikawa, Takao Iwawaki
- Journal Title
  
  Biochem. Biophys. Res. Commun.
  
  Volume: 433 Issue: 4 Pages: 426-431
- DOI
  10.1016/j.bbrc.2013.02.119
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24390049
[Journal Article] 小胞体ストレスの可視化2012
- Author(s)
  岩脇　隆夫
- Journal Title
  
  生体の科学
  
  Volume: 65 Pages: 388-389
- Data Source
  KAKENHI-PUBLICLY-24113702
[Journal Article] 小胞体ストレスの可視化2012
- Author(s)
  岩脇隆夫
- Journal Title
  
  生体の科学
  
  Volume: 65 Pages: 388-389
- Data Source
  KAKENHI-PROJECT-24390049
[Journal Article] Function of yeast and amphioxus tRNA ligase in IRE1alpha-dependent XBP1 mRNA splicing2011
- Author(s)
  Takao Iwawaki
- Journal Title
  
  Biochem.Biophys.Res.Commun.
  
  Volume: 413 Issue: 4 Pages: 527-531
- DOI
  10.1016/j.bbrc.2011.08.129
- Peer Reviewed
- Data Source
  KAKENHI-PUBLICLY-22113524
[Journal Article] Positive contribution of the IRE1alpha-XBP1 pathway to placental expression of CEA family genes.2010
- Author(s)
  Daisuke Oikawa, Ryoko Akai, Takao Iwawaki
- Journal Title
  
  FEBS Lett. vol.584
  
  Pages: 1066-1070
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21790218
[Journal Article] Positive contribution of Erdj5/JPDI to endoplasmic reticulum protein quality control in the salivary gland.2010
- Author(s)
  Akira Hosoda, Mio Tokuda, Ryoko Akai, Kenji Kohno, Takao Iwawaki
- Journal Title
  
  Biochem. J. vol.425
  
  Pages: 117-125
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21790218
[Journal Article] IRE1alpha disruption causes histological abnormality of exocrine tissues, increase of blood glucose level, and decrease of serum immunoglobulin level.2010
- Author(s)
  Takao Iwawaki
- Journal Title
  
  PLoS ONE
  
  Volume: 5
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21790218
[Journal Article] The endoplasmic reticulum stress-CHOP pathway-mediated apoptosis in macrophages contributes to the instability of atherosclerotic plaques.2010
- Author(s)
  Hirato Tsukano, Tomomi Gotoh, Motoyoshi Endo, Miyata Keishi, Hirokazu Tazume, Tsuyoshi Kadomatsu, Masato Yano, Takao Iwawaki, Kenji Kohno, Kimi Araki, Hiroshi Mizuta, Yuichi Oike
- Journal Title
  
  Arterioscler. Thromb. Vasc.Biol. vol.30
  
  Pages: 1925-1932
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21790218
[Journal Article] IRE1alpha disruption causes histological abnormality of exocrine tissues, increase of blood glucose level, and decrease of serum immunoglobulin level.2010
- Author(s)
  Takao Iwawaki, Ryoko Akai, Kenji Kohno
- Journal Title
  
  PLoS ONE vol.5
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21790218
[Journal Article] Identication of a consensus element recognized and cleaved by IRE1alpha.2010
- Author(s)
  Daisuke Oikawa, Mio Tokuda, Akira Hosoda, Takao Iwawaki
- Journal Title
  
  Nucleic Acid Res. vol.38
  
  Pages: 6265-6273
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21790218
[Journal Article] Function of IRE1 alpha in the placenta is essential for placental development and embryonic viability.2009
- Author(s)
  Takao Iwawaki, Ryoko Akai, Shinya Yamanaka, Kenji Kohno
- Journal Title
  
  Proc.Natl.Acad.Sci.USA vol.106
  
  Pages: 16657-16662
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21790218
[Journal Article] Function of IRE1 Alpha in the Placenta is Essential for Placental Development and Embryonic Viability2009
- Author(s)
  Takao Iwawaki
- Journal Title
  
  Proc.Natl.Acad.Sci.USA 106
  
  Pages: 16657-16662
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21790218
[Patent] 炎症レポーターシステム2014
- Inventor(s)
  岩脇隆夫、及川大輔、石川智夫、山村研一
- Industrial Property Rights Holder
  群馬大学、熊本大学、株式会社トランスジェニック
- Industrial Property Rights Type
  特許
- Filing Date
  2014-07-31
- Overseas
- Data Source
  KAKENHI-PROJECT-24390049
[Patent] 酸化ストレスインジケーター発現用核酸構築物とその使用2012
- Inventor(s)
  岩脇隆夫, 及川大輔
- Industrial Property Rights Holder
  独立行政法人理化学研究所
- Filing Date
  2012-01-20
- Overseas
- Data Source
  KAKENHI-PUBLICLY-22113524
[Presentation] 酸化ストレスの視点から尿路結石学と向き合う2023
- Author(s)
  牛本千春子、國井建司郎、井上慎也、赤井良子、黒田絵莉子、岩脇隆夫、宮澤克人
- Organizer
  日本尿路結石症学会第33回学術集会
- Data Source
  KAKENHI-PROJECT-21H03334
[Presentation] 腎結晶形成におけるKeap1-Nrf2 経路を介したストレス応答の関与2023
- Author(s)
  牛本千春子、杉木滋、國井建司郎、井上慎也、赤井良子、黒田絵莉子、岩脇隆夫、宮澤克人
- Organizer
  第26回北陸泌尿器科Research Meeting
- Data Source
  KAKENHI-PROJECT-21H03334
[Presentation] 運動後急性腎不全の機序解明2023
- Author(s)
  野村和利、赤井良子、谷田守、矢部友久、熊野奨、宮竹敦彦、岡田圭一郎、大串勇気、沖野一晃、藤本圭司、倉田康孝、岩脇隆夫、横山仁、古市賢吾
- Organizer
  第66回日本腎臓学会学術総会
- Data Source
  KAKENHI-PROJECT-21H03334
[Presentation] 酸化ストレスの視点から尿路結石学と向き合う2023
- Author(s)
  牛本千春子、國井建司郎、井上慎也、赤井良子、黒田絵莉子、岩脇隆夫、宮澤克人
- Organizer
  第110回日本泌尿器科学会総会
- Data Source
  KAKENHI-PROJECT-21H03334
[Presentation] Deletion of IRE1α Exacerbates Diabetic Nephropathy in Mice2023
- Author(s)
  Andrey V. Cybulsky, Joan Papillon, Julie Guillemette, Jose R. Navarro-Betancourt, Chen-Fang Chung, Takao Iwawaki, Ivan G. Fantus
- Organizer
  KIDNEY WEEK 2023
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21H03334
[Presentation] ATF6β欠損マウスが示す多動表現型と横隔膜ヘルニア2023
- Author(s)
  赤井良子、濱嶋尚代、岩脇隆夫
- Organizer
  第46回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-21H03334
[Presentation] 小胞体ストレス応答のシグナル経路により制御される過食行動の分子メカニズム2022
- Author(s)
  赤井良子、黒田絵莉子、濱嶋尚代、岩脇隆夫
- Organizer
  第69回日本実験動物学会
- Data Source
  KAKENHI-PROJECT-21H03334
[Presentation] Proteostatic sensor Ire1, promotes bone formation by potentiating Wnt signaling in osteoblast progenitors2022
- Author(s)
  Lakshmi Divya Kolora, Christian Melendez-Suchi, Sara Higsley, Veronica Butler, John Lipold, Takao Iwawaki, Maria Almeida, Kartik Shankar, Douglas J Adams, Srividhya Iyer
- Organizer
  Gordon Research Conference (Bones and Teeth)
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21H03334
[Presentation] 腎結晶形成におけるKeap1-Nrf2経路を介したストレス応答の果たす役割2022
- Author(s)
  牛本千春子、國井建司郎、井上慎也、赤井良子、黒田絵莉子、岩脇隆夫、宮澤克人
- Organizer
  第16回臨床ストレス応答学会大会
- Data Source
  KAKENHI-PROJECT-21H03334
[Presentation] ATF6αとATF6βの二重欠損が引き起こすUPR制御機構の代償的変調と細胞機能の関係2022
- Author(s)
  赤井良子、濱嶋尚代、斉藤美知子、河野憲二、岩脇隆夫
- Organizer
  第45回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-21H03334
[Presentation] 腎結晶形成におけるKeap1-Nrf2経路を介したストレス応答の関与2022
- Author(s)
  牛本千春子、國井建司郎、井上慎也、赤井良子、黒田絵莉子、岩脇隆夫、宮澤克人
- Organizer
  第32回日本尿路結石症学会・学術集会
- Data Source
  KAKENHI-PROJECT-21H03334
[Presentation] ATF6αとATF6βの二重欠損が引き起こすUPR制御機構の代償的変調と細胞機能の関係2022
- Author(s)
  赤井良子、黒田絵莉子、濱嶋尚代、斉藤美知子、河野憲二、岩脇隆夫
- Organizer
  第16回臨床ストレス応答学会大会
- Data Source
  KAKENHI-PROJECT-21H03334
[Presentation] 腎結晶形成における Keap1-Nrf2経路を介したストレス応答の解析2022
- Author(s)
  牛本千春子、國井建司郎、井上慎也、黒田絵莉子、赤井良子、岩脇隆夫、宮澤克人
- Organizer
  第31回泌尿器科分子・細胞研究会
- Data Source
  KAKENHI-PROJECT-21H03334
[Presentation] ミトコンドリア異常を可視化するマウスの作製に向けた新規FRETレポーター遺伝子の開発2021
- Author(s)
  黒田絵莉子、赤井良子、濱嶋尚代、岩脇隆夫
- Organizer
  第56回金沢医科大学医学会・学術集会
- Data Source
  KAKENHI-PROJECT-21H03334
[Presentation] 細胞ストレス応答の発展的研究から迫る疲労の分子メカニズム2021
- Author(s)
  岩脇隆夫
- Organizer
  第17回日本疲労学会総会・学術集会
- Invited
- Data Source
  KAKENHI-PROJECT-21H03334
[Presentation] 生体イメージングマウスを用いた腎結晶形成における酸化ストレス応答の解析2021
- Author(s)
  牛本千春子、國井建司郎、井上慎也、赤井良子、岩脇隆夫、宮澤克人
- Organizer
  第31回日本尿路結石症学会・学術集会
- Data Source
  KAKENHI-PROJECT-21H03334
[Presentation] A Non-canonical Role for IRE1α in Podocyte Endoplasmic Reticulum (ER)-phagy2021
- Author(s)
  Jose R. Navarro-Betancourt, Joan Papillon, Julie Guillemette, Takao Iwawaki, Andrey V. Cybulsky
- Organizer
  KIDNEY WEEK 2021
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21H03334
[Presentation] 赤色蛍光／発光レポーターにATF4の翻訳活性化機構を応用した統合ストレス可視化モデルマウスの開発2021
- Author(s)
  赤井良子、黒田絵莉子、濱嶋尚代、岩脇隆夫
- Organizer
  第68回日本実験動物学会
- Data Source
  KAKENHI-PROJECT-21H03334
[Presentation] The ER sensor, IRE1, promotes bone formation by increasing nuclear localization of β-catenin in osteoprogenitors2021
- Author(s)
  Srividhya Iyer, Lakshmi Kolora, Christian Melendez-Suchi, Sara Higsley, Veronica Butler, John Lipold, Takao Iwawaki, Maria Almeida, Kartik Shankar, Douglas Adams
- Organizer
  FASEB SRC The ER Conferences
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21H03334
[Presentation] 炎症性腸疾患における小胞体ストレス応答の関与について2021
- Author(s)
  中山哲雄、栗林志行、岩脇隆夫、平戸純子、深井泰守、富澤琢、橋本悠、田中寛人、草野元康、浦岡俊夫
- Organizer
  第101回日本消化器内視鏡学会総会
- Data Source
  KAKENHI-PROJECT-21H03334
[Presentation] ATF4の翻訳活性化機構に赤色蛍光／発光レポーターを応用した統合ストレス可視化モデルマウスの開発2021
- Author(s)
  赤井良子、黒田絵莉子、濱嶋尚代、岩脇隆夫
- Organizer
  第73回日本細胞生物学会大会
- Data Source
  KAKENHI-PROJECT-21H03334
[Presentation] ENDOPLASMIC RETICULUM STRESS IS ASSOCIATED WITH CLINICAL FEATURES IN PATIENTS WITH INFLAMMATORY BOWEL DISEASE2021
- Author(s)
  Tetsuo Nakayama, Shiko Kuribayashi, Takao Iwawaki, Junko Hirato, Ryoko Akai, Yasumori Fukai, Hirohito Tanaka, Taku Tomizawa, Yu Hashimoto, Motoyasu Kusano, Toshio Uraoka
- Organizer
  Digestive Disease Week 2021
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21H03334
[Presentation] ストレス可視化モデルマウスの開発と疲労研究への応用2020
- Author(s)
  岩脇隆夫、赤井良子
- Organizer
  第16回日本疲労学会総会・学術集会
- Data Source
  KAKENHI-PROJECT-18H02366
[Presentation] IRE1α Is Essential for Podocyte Proteostasis and Mitochondrial Health2020
- Author(s)
  Jose R. Navarro-Betancourt, Joan Papillon, Julie Guillemette, Takao Iwawaki, Andrey V. Cybulsky
- Organizer
  KIDNEY WEEK 2020
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18H02366
[Presentation] Role of IRE1α in Podocyte Proteostasis2019
- Author(s)
  Jose R Navarro-Betancourt, Joan Papillon, Julie Guillemette, Takao Iwawaki, Andrey V Cybulsky
- Organizer
  KIDNEY WEEK 2019
- Data Source
  KAKENHI-PROJECT-18H02366
[Presentation] Comparison between endoscopic and histopathological findings in patients with ulcerative colitis2019
- Author(s)
  Tetsuo Nakayama, Shiko Kuribayashi, Junko Hirato, Takao Iwawaki, Ko Nakata, Hirohito Tanaka, Taku Tomizawa, Hiroko Hosaka, Yasuyuki Shimoyama, Osamu Kawamura, Motoyasu Kusano, Toshio Uraoka
- Organizer
  Digestive Disease Week 2019
- Data Source
  KAKENHI-PROJECT-18H02366
[Presentation] 睡眠不足モデルマウスにおける細胞ストレス応答と炎症反応の生体イメージング2019
- Author(s)
  赤井良子、岩脇隆夫
- Organizer
  第66回日本実験動物学会
- Data Source
  KAKENHI-PROJECT-18H02366
[Presentation] 小胞体ストレス応答分子により制御される過食行動の分子メカニズム2019
- Author(s)
  岩脇隆夫、赤井良子
- Organizer
  第14回臨床ストレス応答学会大会
- Data Source
  KAKENHI-PROJECT-18H02366
[Presentation] ATF4の翻訳活性化機構を利用した統合ストレス可視化モデルマウスの開発2018
- Author(s)
  赤井良子, 岩脇隆夫
- Organizer
  住商ファーマインターナショナル株式会社in vivoイメージングフォーラム2018
- Data Source
  KAKENHI-PROJECT-18H02366
[Presentation] 細菌によって利用される宿主細胞の生体防御反応～小胞体ストレス応答～2018
- Author(s)
  岩脇隆夫
- Organizer
  第55回日本細菌学会中部支部学術集会
- Invited
- Data Source
  KAKENHI-PROJECT-18H02366
[Presentation] 細胞ストレスおよび炎症可視化モデルマウスの開発とその性能2018
- Author(s)
  岩脇隆夫
- Organizer
  第342回熊本大学・発生研セミナー
- Invited
- Data Source
  KAKENHI-PROJECT-18H02366
[Presentation] ATF4の翻訳活性化機構を利用した統合ストレス可視化モデルマウスの開発と疲労研究への応用2018
- Author(s)
  岩脇隆夫, 赤井良子
- Organizer
  第14回日本疲労学会総会・学術集会
- Data Source
  KAKENHI-PROJECT-18H02366
[Presentation] 細胞ストレスおよび炎症可視化モデルマウスの開発とその性能2018
- Author(s)
  岩脇隆夫
- Organizer
  第16回京都薬科大学・実験動物セミナー
- Invited
- Data Source
  KAKENHI-PROJECT-18H02366
[Presentation] 『見えない』を『見える』にするマウス2018
- Author(s)
  岩脇隆夫
- Organizer
  第20回KMU研究推進セミナー
- Data Source
  KAKENHI-PROJECT-18H02366
[Presentation] ATF4の翻訳活性化機構を利用した統合ストレス可視化モデルマウスの開発2018
- Author(s)
  赤井良子, 岩脇隆夫
- Organizer
  第65回日本実験動物学会
- Data Source
  KAKENHI-PROJECT-18H02366
[Presentation] 異常行動およびエイジングにまで拡がる小胞体ストレス研究の新展開2017
- Author(s)
  岩脇隆夫
- Organizer
  東京大学大学院薬学系研究科遺伝学教室主催研究集会2017
- Place of Presentation
  和光純薬湯河原研修所（静岡県熱海市）
- Year and Date
  2017-03-12
- Data Source
  KAKENHI-PROJECT-15K15038
[Presentation] 酸化ストレス可視化マウスを用いた脳マラリアの新しい評価法2014
- Author(s)
  今井孝、岩脇隆夫、赤井良子、鈴江一友、平井誠、谷口委代、岡田紘子、久枝一
- Organizer
  第83回日本寄生虫学会大会
- Place of Presentation
  愛媛大学
- Data Source
  KAKENHI-PROJECT-24390049
[Presentation] The role of ER stress responses in the control of blood glucose and the biosynthesis of insulin2014
- Author(s)
  Ryoko Akai, Takao Iwawaki
- Organizer
  7th APOCB Congress and ASCB Workshops
- Place of Presentation
  Biopolis（シンガポール）
- Data Source
  KAKENHI-PROJECT-24390049
[Presentation] Positive contribution of IRE1α-XBP1 pathway to the expression of placental cathepsins2014
- Author(s)
  Takao Iwawaki, Daisuke Oikawa
- Organizer
  7th APOCB Congress and ASCB Workshops
- Place of Presentation
  Biopolis（シンガポール）
- Data Source
  KAKENHI-PROJECT-24390049
[Presentation] 胎盤でのCathepsin遺伝子発現制御におけるIRE1αおよびXBP1の役割2013
- Author(s)
  岩脇隆夫、及川大輔
- Organizer
  第60回北関東医学会総会
- Place of Presentation
  群馬大学
- Data Source
  KAKENHI-PROJECT-24390049
[Presentation] Fatty acid flux regulates IRE1α activity to control the NLRP3 inflammasome in myeloid cells2013
- Author(s)
  Megan Robblee, Jess P. Abate, Alex Samocha, Takao Iwawaki, Suneil K. Koliwad
- Organizer
  The 2013 Meeting on Metabolic Signaling & Disease
- Place of Presentation
  Cold Spring Harbor（米国）
- Data Source
  KAKENHI-PROJECT-24390049
[Presentation] Intrinsically disordered regions in handling of misfolded/unfolded proteins in the ER2013
- Author(s)
  Takao Iwawaki
- Organizer
  The 2nd ISIDP International Symposium
- Place of Presentation
  RIKEN, Yokohama
- Year and Date
  2013-01-23
- Data Source
  KAKENHI-PUBLICLY-24113702
[Presentation] 細胞ストレス可視化モデルマウスの開発とその性能2013
- Author(s)
  岩脇隆夫
- Organizer
  第86回日本生化学会バイオインダストリーセミナー
- Place of Presentation
  パシフィコ横浜
- Invited
- Data Source
  KAKENHI-PROJECT-24390049
[Presentation] 細胞内異常タンパク質代謝における天然変性領域の役割2012
- Author(s)
  岩脇隆夫
- Organizer
  新学術領域研究「天然変性タンパク質の分子認識機構と機能発現」第2回公開シンポジウム
- Place of Presentation
  千里ラィフサイェンスセンター(招待講演)
- Year and Date
  2012-01-25
- Data Source
  KAKENHI-PUBLICLY-22113524
[Presentation] 小胞体ストレスを『より簡便』に検出する方法2012
- Author(s)
  岩脇隆夫
- Organizer
  日本薬学会第132年会
- Place of Presentation
  北海道大学(招待講演)
- Year and Date
  2012-03-29
- Data Source
  KAKENHI-PUBLICLY-22113524
[Presentation] 細胞ストレス可視化モデルマウスの開発とその性能2012
- Author(s)
  岩脇隆夫
- Organizer
  細胞センサーの分子機構・相互作用・ネットワーク研究会
- Place of Presentation
  生理学研究所
- Data Source
  KAKENHI-PROJECT-24390049
[Presentation] 酸化ストレス可視化モデルマウスの開発2012
- Author(s)
  岩脇隆夫
- Organizer
  第8回日本疲労学会総会・学術集会
- Place of Presentation
  国立スポーツ科学センター
- Data Source
  KAKENHI-PROJECT-24390049
[Presentation] IRE1αとIRE1βによる小胞体ストレス感知機構の違い2012
- Author(s)
  岩脇　隆夫
- Organizer
  第7回小胞体ストレス研究会
- Place of Presentation
  広島大学
- Year and Date
  2012-11-09
- Data Source
  KAKENHI-PUBLICLY-24113702
[Presentation] 胎盤における小胞体ストレス応答分子の機能2012
- Author(s)
  岩脇隆夫
- Organizer
  第4回群馬分子医学研究会
- Place of Presentation
  群馬大学
- Year and Date
  2012-10-20
- Data Source
  KAKENHI-PROJECT-24390049
[Presentation] 動物個体における小胞体ストレスと酸化ストレスのイメージング技術の開発2011
- Author(s)
  岩脇隆夫
- Organizer
  第10回国際バイオEXPO
- Place of Presentation
  東京ビッグサイト
- Year and Date
  2011-06-30
- Data Source
  KAKENHI-PUBLICLY-22113524
[Presentation] Screening for XBP1 splicing-associated RNA ligase2011
- Author(s)
  岩脇隆夫
- Organizer
  第34回日本分子生物学会年会
- Place of Presentation
  パシフィコ横浜
- Year and Date
  2011-12-15
- Data Source
  KAKENHI-PUBLICLY-22113524
[Presentation] Transgenic mouse models for monitoring cellular stress2011
- Author(s)
  Iwawaki Takao
- Organizer
  奈良先端未来開拓コロキウム"Protein and Organelle Dynamics under Cellular Stress Conditions"
- Place of Presentation
  奈良先端科学技術大学院大学(招待講演)
- Year and Date
  2011-05-31
- Data Source
  KAKENHI-PUBLICLY-22113524
[Presentation] 酸化ストレス可視化モデルマウスの開発2011
- Author(s)
  岩脇隆夫
- Organizer
  第6回IVISユーザー会
- Place of Presentation
  パシフィコ横浜(招待講演)
- Year and Date
  2011-11-04
- Data Source
  KAKENHI-PUBLICLY-22113524
[Presentation] XBP1のスプライシングに関わるRNAリガーゼのスクリーニング2011
- Author(s)
  岩脇隆夫
- Organizer
  第63回日本細胞生物学会
- Place of Presentation
  北海道大学
- Year and Date
  2011-06-27
- Data Source
  KAKENHI-PUBLICLY-22113524
[Presentation] マウス個体における酸化ストレスイメージングシステムの開発2011
- Author(s)
  岩脇隆夫
- Organizer
  第6回臨床ストレス応答学会
- Place of Presentation
  名古屋大学医学部
- Year and Date
  2011-11-05
- Data Source
  KAKENHI-PUBLICLY-22113524
[Presentation] 膵臓β細胞でのインスリン産生におけるIRE1とATF6の役割2010
- Author(s)
  藤岡洋美、土屋雄一、斉藤美知子、岩脇隆夫、森和俊、河野憲二
- Organizer
  第33回日本分子生物学会・第83回日本生化学会合同年会
- Place of Presentation
  神戸
- Year and Date
  2010-12-10
- Data Source
  KAKENHI-PROJECT-21790218
[Presentation] The role of ER stress responses in the control of blood glucose levels and the biosynthesis of insulin2010
- Author(s)
  Takao Iwawaki
- Organizer
  The 3rd International Symposium on Protein Community
- Place of Presentation
  Nara
- Year and Date
  2010-09-13
- Data Source
  KAKENHI-PROJECT-21790218
[Presentation] The role of ER stress responses in the control of blood glucose levels and the biosynthesis of insulin2010
- Author(s)
  Takao Iwawaki, Akira Hosoda, Ryoko Akai, Mio Tokuda
- Organizer
  The 3rd International Symposium on Protein Community
- Place of Presentation
  in Nara
- Year and Date
  2010-09-13
- Data Source
  KAKENHI-PROJECT-21790218
[Presentation] 血糖値調節およびインスリン生合成における小胞体ストレス応答の役割2010
- Author(s)
  岩脇隆夫
- Organizer
  第5回臨床ストレス応答学会
- Place of Presentation
  徳島
- Year and Date
  2010-11-19
- Data Source
  KAKENHI-PROJECT-21790218
[Presentation] 血糖値調節およびインスリン生合成における小胞体ストレス応答の役割2010
- Author(s)
  岩脇隆夫、細田章、赤井良子、徳田美緒
- Organizer
  第33回日本分子生物学会・第83回日本生化学会合同年会
- Place of Presentation
  神戸
- Year and Date
  2010-12-10
- Data Source
  KAKENHI-PROJECT-21790218
[Presentation] 血糖値調節およびインスリン生合成における小胞体ストレス応答の役割2010
- Author(s)
  岩脇隆夫、細田章、赤井良子、徳田美緒
- Organizer
  第5回臨床ストレス応答学会
- Place of Presentation
  徳島大
- Year and Date
  2010-11-19
- Data Source
  KAKENHI-PROJECT-21790218
[Presentation] 胎盤形成における小胞体ストレスセンサーとビタミンEの役割2009
- Author(s)
  岩脇隆夫
- Organizer
  エーザイ株式会社第12回Vitamin E Update Forum
- Place of Presentation
  如水会館、東京
- Year and Date
  2009-08-31
- Data Source
  KAKENHI-PROJECT-21790218
[Presentation] Contribution of IRE1 signaling to placental angiogenesis and functuion for embryogenesis2009
- Author(s)
  岩脇隆夫
- Organizer
  The 4th International Congress on Stress Responses in Biology and Medicine
- Place of Presentation
  Sapporo
- Year and Date
  2009-10-08
- Data Source
  KAKENHI-PROJECT-21790218
[Presentation] Genome-wide screening method for the cleavage target of IRE1alpha2009
- Author(s)
  Daisuke Oikawa, Mio Tokuda, Akira Hosoda, Takao Iwawaki
- Organizer
  The 32nd Annual Meeting of the Molecular Biology Society of Japan
- Place of Presentation
  in Yokohama
- Year and Date
  2009-12-12
- Data Source
  KAKENHI-PROJECT-21790218
[Presentation] Positive contribution of ERdj5/JPDI to endoplasmic reticulum protein quality control in the salivary gland2009
- Author(s)
  Akira Hosoda, Mio Tokuda, Ryoko Akai, Kenji Kohno, Takao Iwawaki
- Organizer
  The 4th International Congress on Stress Responses in Biology and Medicine
- Place of Presentation
  in Sapporo
- Year and Date
  2009-10-08
- Data Source
  KAKENHI-PROJECT-21790218
[Presentation] Phenotype analysis of IRE1 alpha conditional knockout mice2009
- Author(s)
  Ryoko Akai, Kenji Kohno, Takao Iwawaki
- Organizer
  The 4th International Congress on Stress Responses in Biology and Medicine
- Place of Presentation
  in Sapporo
- Year and Date
  2009-10-08
- Data Source
  KAKENHI-PROJECT-21790218
[Presentation] 胎盤形成における小胞体ストレスセンサーとビタミンEの役割2009
- Author(s)
  岩脇隆夫
- Organizer
  エーザイ株式会社第12回 Vitamin E Update Forum
- Place of Presentation
  東京
- Year and Date
  2009-08-31
- Data Source
  KAKENHI-PROJECT-21790218
[Presentation] PSG遺伝子群の胎盤発現に対するIRE1a-XBP1経路の貢献2009
- Author(s)
  及川大輔、赤井良子、岩脇隆夫
- Organizer
  第61回日本細胞生物学会
- Place of Presentation
  名古屋
- Year and Date
  2009-06-04
- Data Source
  KAKENHI-PROJECT-21790218
[Presentation] Positive contribution of ERdj5/JPDI to endoplasmic reticulum protein quality control in the salivary gland2009
- Author(s)
  Akira Hosoda, Mio Tokuda, Ryoko Akai, Kenji Kohno, Takao Iwawaki
- Organizer
  The 32nd Annual Meeting of the Molecular Biology Society of Japan
- Place of Presentation
  in Yokohama
- Year and Date
  2009-12-12
- Data Source
  KAKENHI-PROJECT-21790218
[Presentation] Contribution of IRE1alpha-XBP1 pathway to the placental expression of PSG genes2009
- Author(s)
  Daisuke Oikawa, Ryoko Akai, Takao Iwawaki
- Organizer
  The 4th International Congress on Stress Responses in Biology and Medicine, Poster Presentation
- Place of Presentation
  in Sapporo
- Year and Date
  2009-10-08
- Data Source
  KAKENHI-PROJECT-21790218
[Presentation] Contribution of IRE1 signaling to placental angiogenesis and function for embryogenesis2009
- Author(s)
  Takao Iwawaki, Ryoko Akai, Shinya Yamanaka, Kenji Kohno
- Organizer
  The 4th International Congress on Stress Responses in Biology and Medicine
- Place of Presentation
  in Sapporo
- Year and Date
  2009-10-08
- Data Source
  KAKENHI-PROJECT-21790218
[Presentation] 群馬大学で名付けられた遺伝子、IRE1
- Author(s)
  岩脇隆夫
- Organizer
  第61回北関東医学会総会
- Place of Presentation
  群馬大（群馬県前橋市）
- Year and Date
  2014-09-25 – 2014-09-26
- Data Source
  KAKENHI-PROJECT-24390049
[Presentation] 細胞ストレス可視化モデルマウスの開発とその性能
- Author(s)
  岩脇隆夫
- Organizer
  岡山大＆理研ジョイントシンポジウム「最先端計測技術のトレンド2013」
- Place of Presentation
  岡山大学
- Invited
- Data Source
  KAKENHI-PROJECT-24390049
[Presentation] 動物個体レベルでみる小胞体ストレス応答分子IRE1αの役割
- Author(s)
  岩脇隆夫
- Organizer
  第122回東京大学生命環境科学セミナー
- Place of Presentation
  東京大学
- Invited
- Data Source
  KAKENHI-PROJECT-24390049
[Presentation] 小胞体ストレス応答不全による糖尿病発症機構の解明
- Author(s)
  斉藤美知子、土屋雄一、岩脇隆夫、森和俊、宮崎純一、河野憲二
- Organizer
  第37回日本分子生物学会年会
- Place of Presentation
  パシフィコ横浜（神奈川県横浜市）
- Year and Date
  2014-11-25 – 2014-11-27
- Data Source
  KAKENHI-PROJECT-24390049
[Presentation] Unfolded protein response is differently activated by membrane lipid saturation and unfolded proteins in the endoplasmic reticulum
- Author(s)
  Nozomu Kono, Yuto Kitai, Hiroyuki Ariyama, Daisuke Oikawa, Takao Iwawaki, Hiroyuki Arai
- Organizer
  FASEB SRC: Phospholipid Cell Signaling and Metabolism in Inflammation and Cancer
- Place of Presentation
  Niagara Falls (USA)
- Year and Date
  2014-06-01 – 2014-06-06
- Data Source
  KAKENHI-PROJECT-24390049
[Presentation] メチル水銀誘発性神経細胞死における小胞体ストレスの関与
- Author(s)
  奥田洸作、牧野堅人、外山喬士、西屋禎、岩脇隆夫、熊谷嘉人、上原孝
- Organizer
  第123回日本薬理学会近畿部会
- Place of Presentation
  ウインクあいち
- Data Source
  KAKENHI-PROJECT-24390049
[Presentation] 細胞ストレス可視化モデルマウスの開発とその性能
- Author(s)
  岩脇隆夫
- Organizer
  第5回実験動物センター・テクニカルセミナー
- Place of Presentation
  東京医科歯科大学
- Invited
- Data Source
  KAKENHI-PROJECT-24390049
[Presentation] 細胞ストレス可視化モデルマウスの開発とその性能
- Author(s)
  岩脇隆夫
- Organizer
  第8回医工連携グループミーティング
- Place of Presentation
  群馬大学
- Invited
- Data Source
  KAKENHI-PROJECT-24390049
[Presentation] インスリン生合成に必要な膵臓ベータ細胞におけるeIF2αキナーゼとホスファターゼのバランス機構
- Author(s)
  岩脇隆夫、赤井良子、細田章、徳田美緒
- Organizer
  第37回日本分子生物学会年会
- Place of Presentation
  パシフィコ横浜（神奈川県横浜市）
- Year and Date
  2014-11-25 – 2014-11-27
- Data Source
  KAKENHI-PROJECT-24390049
[Presentation] 小胞体ストレスセンサーIRE1αによる細胞質スプライシングに必要なmRNAの構造及び配列の解析
- Author(s)
  池端悠介、今川佑介、柳谷耕太、田丸良子、金谷重彦、岩脇隆夫、河野憲二
- Organizer
  第66回日本細胞生物学会
- Place of Presentation
  東大寺総合文化センター（奈良県奈良市）
- Year and Date
  2014-06-11 – 2014-06-13
- Data Source
  KAKENHI-PROJECT-24390049
[Presentation] インスリン産生細胞における小胞体ストレスセンサーIRE1alphaの生理的役割
- Author(s)
  土屋雄一、斉藤美知子、岩脇隆夫、宮崎純一、河野憲二
- Organizer
  第66回日本細胞生物学会
- Place of Presentation
  東大寺総合文化センター（奈良県奈良市）
- Year and Date
  2014-06-11 – 2014-06-13
- Data Source
  KAKENHI-PROJECT-24390049
[]

1. 田中貴士 (30734694)

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2. 堀修 (60303947)

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3. 竹屋元裕 (90155052)

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4. 古山貴文 (20802268)

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5. 浦大樹 (90624958)

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6. 田中聡 (10321944)

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7. 八田稔久 (20238025)

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8. 清水陽 (30808077)

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9. 坂田ひろみ (50294666)

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10. 茂田大地 (40974663)

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11. 友杉充宏 (60533429)

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12. OIKAWA Daisuke

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# of Collaborated Products: 6 results
13. TAKAHASHI Yayoi

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14. ASAI Chiaki

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15. YOSHINO Mayuko

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16. AKAI Ryoko

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
17. SAITO Michiko

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18. SUZUKI Takafumi

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19. 門倉広

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20. 河野憲二

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21. 平井誠

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22. 改正恒康

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23. 上原孝

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24. 伊藤昭博

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25. 熊谷嘉人

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Iwawaki Takao 岩脇 隆夫

IWAWAKI Takao 岩脇 隆夫

岩脇 隆夫 イワワキ タカオ

Research Projects

Research Products

Co-Researchers

Functional analysis of endoplasmic reticulum stress disorders in the brain with a view to therapeutic interventions for inappropriate parenting

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疲労時に活性化する細胞ストレス応答の生体保護的な役割を解明するためにPrincipal Investigator

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Mechanisms of Acute Hepatocellular Necrosis Caused by Prenatal Exposure to Maternal Inflammation

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ミトコンドリアで生じる早期の機能的ストレスを可視化するモデルマウス開発Principal Investigator

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Molecular Cell Biology of Fatigue Mechanisms Approached from Developmental Studies of Cellular Stress and InflammationPrincipal Investigator

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Transgenic mice for imaging of cellular stress associated with diseases and agingPrincipal Investigator

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Molecular mechanism of overeating regulated by cellular stress responsePrincipal Investigator

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異常タンパク質インターフェイスとしての天然変性領域の機能解析Principal Investigator

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Physiological and Pathological Function of Cellular Stress ResponsesPrincipal Investigator

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「天然」変性タンパク質による「非天然」変性タンパク質の感知・認識機構の解析Principal Investigator

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Identification of novel ER stress responsive pathways that function in intercellular interactionPrincipal Investigator

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小胞体ストレス細胞死における分子制御機構の解明Principal Investigator

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[Journal Article] Unconventional Activation of IRE1 Enhances TH17 Responses and Promotes Airway Neutrophilia2024

Author(s)

Iwawaki Takao 岩脇隆夫

IWAWAKI Takao 岩脇隆夫

岩脇隆夫イワワキタカオ