Higashio Hironori 東尾浩典

… Alternative Names

Researcher Number	50342837
Other IDs
External Links
Affiliation (Current)	2022: 岩手医科大学, 教養教育センター, 准教授
Affiliation (based on the past Project Information) *help	2014 – 2020: 岩手医科大学, 教養教育センター, 講師 2013: 助教 2013: 岩手医科大学, 共通教育センター, 講師 2011 – 2013: 岩手医科大学, 公私立大学の部局等, 講師 2007: The University of Tokushima, 大学院・ヘルスバイオサイエンス研究部, 助教 2006: 徳島大学, 大学院・ヘルスバイオサイエンス研究部, 助手
Review Section/Research Field	Principal Investigator General medical chemistry / General anatomy (including histology/embryology) / Eating habits / Basic Section 48010:Anatomy-related Except Principal Investigator General anatomy (including Histology/Embryology)
Keywords	Principal Investigator マスト細胞 / 調節性分泌 / 脱顆粒 / ライブイメージング / 即時型アレルギー / 蛍光プローブ / イメージング / 小胞輸送 / カルシウムセンサー / リソソーム … More Except Principal Investigator 解剖学 / 細胞・組織 / シグナル伝達 / 生理活性 / 脂肪酸ｴﾁﾙｴｽﾃﾙ / 脂肪酸エチルエステル / 細胞内カルシウム濃度 / 膵腺房細胞 / 血球 / 細静脈 / 高速共焦点レーザー顕微鏡 / マスト細胞 / 細胞死イメージング Less

マスト細胞の脱顆粒応答は分泌刺激の種類で変化するか？―イメージングによる解析―Principal Investigator
- Principal Investigator
  
  東尾浩典
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 48010:Anatomy-related
- Research Institution
  Iwate Medical University
Fluorescent-based method for monitoring mast cell degranulationPrincipal Investigator
- Principal Investigator
  
  Higashio Hironori
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Eating habits
- Research Institution
  Iwate Medical University
Live imaging of mast cell degranulation and its application to spatiotemporal analyses of the degranulation-related genesPrincipal Investigator
- Principal Investigator
  
  Higashio Hironori
- Project Period (FY)
  2013 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  General anatomy (including histology/embryology)
- Research Institution
  Iwate Medical University
Effect of FAEEs on intracellular signalling
- Principal Investigator
  
  SATOH Yoh-ichi
- Project Period (FY)
  2011 – 2013
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  General anatomy (including Histology/Embryology)
- Research Institution
  Iwate Medical University
カルシウムセンサータンパク質Doc2による小胞輸送制御機構の解析Principal Investigator
- Principal Investigator
  
  東尾浩典
- Project Period (FY)
  2006 – 2007
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  General medical chemistry
- Research Institution
  The University of Tokushima

All 2020 2018 2017 2016 2015 2014 2013 2008 2007 Other

All Journal Article Presentation

[Journal Article] 3D image reconstruction techniques using STEM for arteriole and venule morphological analyses2020
- Author(s)
  Hirakawa M., Satoh YI., Mchonde GJ., Higashio H., and Seino T.
- Journal Title
  
  Annual Reports of Iwate Medical University Center for Liberal Arts and Sciences
  
  Volume: 55 Pages: 115-125
- NAID
  40022479421
- Data Source
  KAKENHI-PROJECT-19K07272
[Journal Article] Anti-allergy activities of Kuji amber extract and kujigamberol.2018
- Author(s)
  Maruyama M., Kobayashi M., Uchida T., Shimizu E., Higashio H., Ohno M., Uesugi S., Kimura KI.
- Journal Title
  
  Fitoterapia
  
  Volume: 印刷中 Pages: 263-270
- DOI
  10.1016/j.fitote.2018.02.033
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16K12730, KAKENHI-PROJECT-16H04910
[Journal Article] Inhibitory role of Munc13-1 in antigen-induced mast cell degranulation 2017
- Author(s)
 Higashio H, Satoh YI, Saino T.
- Journal Title
 
 Biomedical Research
 
 Volume: 38 Issue: 6 Pages: 321-329
- DOI
 10.2220/biomedres.38.321
- NAID
 130006248384
- ISSN
 0388-6107, 1880-313X
- Language
 English
- Peer Reviewed / Open Access
- Data Source
 KAKENHI-PROJECT-17K08516, KAKENHI-PROJECT-16K12730
[Journal Article] Mast cell degranulation is negatively regulated by the Munc13-4-binding small-guanosine triphosphatase Rab372016
- Author(s)
  Higashio H., Satoh Y., and Saino T.
- Journal Title
  
  Scientific Reports
  
  Volume: 6 Pages: 22539-22539
- DOI
  10.1038/srep22539
- NAID
  120005944301
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-25460274
[Journal Article] P2Y purinoceptors mediate ATP-induced changes in intracellular calcium and amylase release in acinar cells of mouse parotid glands 2016
- Author(s)
 Moriguchi-Mori K1, Higashio H, Isobe K, Kumagai M, Sasaki K, Satoh Y, Kuji A, Saino T
- Journal Title
 
 Biomedical Research
 
 Volume: 37 Issue: 1 Pages: 37-49
- DOI
 10.2220/biomedres.37.37
- NAID
 130005128376
- ISSN
 0388-6107, 1880-313X
- Language
 English
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
 KAKENHI-PROJECT-26460100, KAKENHI-PROJECT-25460274
[Journal Article] α1-Adrenoceptors relate Ca2+ modulation and protein secretions in rat lacrimal gland 2015
- Author(s)
 Ikeda-Kurosawa C., Higashio H., Nakano M., Okubo M., Satoh Y., Kurosaka D., and Saino T.
- Journal Title
 
 Biomedical Research
 
 Volume: 36 Issue: 6 Pages: 357-369
- DOI
 10.2220/biomedres.36.357
- NAID
 130005116838
- ISSN
 0388-6107, 1880-313X
- Language
 English
- Peer Reviewed / Open Access
- Data Source
 KAKENHI-PROJECT-25460274
[Journal Article] Doc2a and Muncl3-4 regulate Ca^<2+>dependent secretory lysosome exocytosis in mast cells.2008
- Author(s)
 Higashio, H.
- Journal Title
 
 J. Immunol. 180
 
 Pages: 4774-4784
- Peer Reviewed
- Data Source
 KAKENHI-PROJECT-18790204
[Journal Article] Smy2p participates in COPII vesicle formation through the interaction with Sec23p/Sec24p subcomplex.2008
- Author(s)
  Higashio, H.
- Journal Title
  
  Traffic 9
  
  Pages: 79-93
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18790204
[Presentation] マスト細胞におけるMunc13-1の発現と脱顆粒への関わり2017
- Author(s)
  東尾浩典、佐藤洋一、齋野朝幸
- Organizer
  第69回日本細胞生物学会大会
- Data Source
  KAKENHI-PROJECT-16K12730
[Presentation] シェーグレン症候群での耳下腺分泌障害には交感神経系が関与している可能性がある2017
- Author(s)
  守口霞、東尾浩典、横山拓矢、久慈昭慶、佐藤洋一、齋野朝幸
- Organizer
  第63回日本解剖学会東北・北海道連合支部学術集会
- Data Source
  KAKENHI-PROJECT-16K12730
[Presentation] 低分子量GTPase Rab37はマスト細胞の脱顆粒を負に制御する2015
- Author(s)
  東尾浩典、佐藤洋一、齋野朝幸
- Organizer
  第54回日本薬学会東北支部大会
- Place of Presentation
  岩手県矢巾町
- Year and Date
  2015-09-26
- Data Source
  KAKENHI-PROJECT-25460274
[Presentation] ATP受容体刺激によるマウス耳下腺腺房細胞の細胞内Ca2+濃度上昇はP2Y受容体が主である2015
- Author(s)
  守口-森霞、東尾浩典、磯部可奈子、熊谷美保、佐藤洋一、久慈昭慶、齋野朝幸
- Organizer
  第61回日本解剖学会東北・北海道連合支部学術集会
- Place of Presentation
  盛岡
- Year and Date
  2015-08-29
- Data Source
  KAKENHI-PROJECT-25460274
[Presentation] Ca2+シグナル伝達に関わる遺伝子変異酵母に作用する物質のRBL-2H3細胞への効果2015
- Author(s)
  大川祐介、小林幹、東尾浩典、塩野義人、上杉祥太、木村賢一
- Organizer
  日本生化学会東北支部第81回例会
- Place of Presentation
  仙台
- Year and Date
  2015-05-09
- Data Source
  KAKENHI-PROJECT-25460274
[Presentation] 低分子量GTPase Rab37によるマスト細胞脱顆粒の抑制的制御2015
- Author(s)
  東尾浩典、佐藤洋一、齋野朝幸
- Organizer
  第67回日本細胞生物学会大会
- Place of Presentation
  東京
- Year and Date
  2015-06-30
- Data Source
  KAKENHI-PROJECT-25460274
[Presentation] Ca2+シグナル伝達に関わる遺伝子変異酵母に作用する物質の RBL-2H3 細胞への効果2015
- Author(s)
  大川佑介、小林幹、東尾浩典、塩野義人、上杉祥太、木村賢一
- Organizer
  日本生化学会東北支部第81回例会
- Place of Presentation
  東北大学（仙台）
- Year and Date
  2015-05-09
- Data Source
  KAKENHI-PROJECT-25460274
[Presentation] ノルアドレナリンはα1 受容体を介して涙腺腺房細胞からムチン分泌を促す2014
- Author(s)
  黒澤千花、齋野朝幸、東尾浩典、佐藤洋一、黒坂大次郎
- Organizer
  日本解剖学会第60回東北・北海道連合支部学術集会
- Place of Presentation
  福島学院大学（福島）
- Year and Date
  2014-09-07
- Data Source
  KAKENHI-PROJECT-25460274
[Presentation] マスト細胞の脱顆粒における低分子量GTPase Rab37の役割2014
- Author(s)
  東尾浩典、齋野朝幸、佐藤洋一
- Organizer
  第66回日本細胞生物学会大会
- Place of Presentation
  奈良県公会堂（奈良）
- Year and Date
  2014-06-13
- Data Source
  KAKENHI-PROJECT-25460274
[Presentation] The GTPase Rab37 participates in the control of mast cell degranulation2013
- Author(s)
  Higashio H, Satoh Y
- Organizer
  第36回日本分子生物学会年会
- Place of Presentation
  神戸
- Data Source
  KAKENHI-PROJECT-23590241
[Presentation] マスト細胞の調節性分泌におけるDoc2の役割2007
- Author(s)
  東尾浩典
- Organizer
  第59回日本細胞生物学会
- Place of Presentation
  福岡
- Year and Date
  2007-05-30
- Data Source
  KAKENHI-PROJECT-18790204
[Presentation] マスト細胞の調節性分泌におけるDoc2α-Muncl3-4系の役割2007
- Author(s)
  東尾浩典
- Organizer
  第30回日本分子生物学会年会・第80回日本生化学会大会合同大会BMB2007
- Place of Presentation
  横浜
- Year and Date
  2007-12-13
- Data Source
  KAKENHI-PROJECT-18790204
[Presentation] 低分子量GTPase Rab37によるマスト細胞脱顆粒の制御
- Author(s)
  東尾浩典、佐藤洋一
- Organizer
  日本分子生物学会
- Place of Presentation
  神戸
- Data Source
  KAKENHI-PROJECT-25460274
[Presentation] マスト細胞の脱顆粒における低分子量GTPase Rab37の役割
- Author(s)
  東尾浩典、齋野朝幸、佐藤洋一
- Organizer
  日本細胞生物学会
- Place of Presentation
  奈良
- Data Source
  KAKENHI-PROJECT-25460274
[Presentation] 琥珀に含まれる生物活性物質の抗アレルギー作用
- Author(s)
  小林幹、内田武史、阿部友美、新田久男、東尾浩典、上杉昇太、木村賢一
- Organizer
  日本農芸化学会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-25460274
[Presentation] 低分子量GTPase Rab37によるマスト細胞脱顆粒の抑制的制御
- Author(s)
  東尾浩典、佐藤洋一、齋野朝幸
- Organizer
  第67回日本細胞生物学会大会
- Place of Presentation
  タワーホール船堀（東京）
- Year and Date
  2015-06-30 – 2015-07-01
- Data Source
  KAKENHI-PROJECT-25460274

1. 齋野朝幸 (40305991)

# of Collaborated Projects: 3 results

# of Collaborated Products: 4 results
2. SATOH Yoh-ichi (40118253)

# of Collaborated Projects: 2 results

# of Collaborated Products: 13 results
3. NAKANO Masato (50237351)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
4. 松浦誠 (00405846)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
5. 葉原芳昭 (30142813)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. 石田陽治 (70151389)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. 永井健治 (20311350)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. 小笠原邦昭 (00305989)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. 阿久津仁美 (30398482)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. 吉田潤 (20611007)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. 横山拓矢 (70772094)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
12. KIMURA Ken-ichi

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Higashio Hironori 東尾 浩典

東尾 浩典 ヒガシオ ヒロノリ

Research Projects

Research Products

Co-Researchers

マスト細胞の脱顆粒応答は分泌刺激の種類で変化するか？―イメージングによる解析―Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Fluorescent-based method for monitoring mast cell degranulationPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Live imaging of mast cell degranulation and its application to spatiotemporal analyses of the degranulation-related genesPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Effect of FAEEs on intracellular signalling

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

カルシウムセンサータンパク質Doc2による小胞輸送制御機構の解析Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] 3D image reconstruction techniques using STEM for arteriole and venule morphological analyses2020

Author(s)

Journal Title

NAID

Data Source

[Journal Article] Anti-allergy activities of Kuji amber extract and kujigamberol.2018

Author(s)

Journal Title

DOI

Data Source

[Journal Article] <b>Inhibitory role of Munc13-1 in antigen-induced mast cell </b><b>degranulation </b>2017

Author(s)

Journal Title

DOI

NAID

ISSN

Language

Data Source

[Journal Article] Mast cell degranulation is negatively regulated by the Munc13-4-binding small-guanosine triphosphatase Rab372016

Author(s)

Journal Title

DOI

NAID

Data Source

[Journal Article] <b>P2Y purinoceptors mediate ATP-induced changes in intracellular calcium and amylase release in acinar cells of mouse parotid </b><b>glands </b>2016

Author(s)

Journal Title

DOI

NAID

ISSN

Language

Data Source

[Journal Article] <b>α1-Adrenoceptors relate Ca</b><sup><b>2+</b></sup><b> modulation and protein secretions in rat lacrimal </b><b>gland </b>2015

Author(s)

Journal Title

DOI

NAID

ISSN

Language

Data Source

[Journal Article] Doc2a and Muncl3-4 regulate Ca^<2+>dependent secretory lysosome exocytosis in mast cells.2008

Author(s)

Journal Title

Data Source

[Journal Article] Smy2p participates in COPII vesicle formation through the interaction with Sec23p/Sec24p subcomplex.2008

Higashio Hironori 東尾浩典

東尾浩典ヒガシオヒロノリ