NAGASAWA Masahiro 長澤雅裕

Researcher Number	50343083
Affiliation (based on the past Project Information) *help	2007 – 2017: Gunma University, 生体調節研究所, 助教 2003 – 2004: 群馬大学, 生体調節研究所, 助手
Review Section/Research Field	Principal Investigator General surgery Except Principal Investigator Metabolomics
Keywords	Principal Investigator カルシウム / TRPチャネル / トランスロケーション / カルシウムチャネル / TRPV2チャネル / 伸展刺激 / TRPV2 / TRPV / 癌 / 細胞運動 … More / 癌細胞 / 機械受容チャネル / メカノセンサー / ビンキュリン / 機械受容 / calcium / macrophage / TRP channels / 増殖因子 / TRPVファミリー / マクロファージ / 機械刺激 / 機械受容カルシウムチャネル / がん / TRP / 癌転移 … More Except Principal Investigator cell therapy / cell transplantation / stem cell / regenerative medicine / diabetes / insulin / 分化誘導因子 / 再生医学 / 膵β細胞 / 細胞療法 / 細胞移植 / 幹細胞 / 再生医療 / 糖尿病 / インスリン Less

The regulation of focal mechanical stress on the localization of TRPV2 was investigated in the fibrosarcoma cells.Principal Investigator
- Principal Investigator
  
  Nagasawa Masahiro
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  General surgery
- Research Institution
  Gunma University
The effect of focal mechanical stress on the localization of TRPV2 was investigated in the fibrosarcoma cells.Principal Investigator
- Principal Investigator
  
  nagasawa masahiro
- Project Period (FY)
  2012 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  General surgery
- Research Institution
  Gunma University
The role of TRPV2 channel trafficking in cancer cell adhesion and motilityPrincipal Investigator
- Principal Investigator
  
  NAGASAWA Masahiro
- Project Period (FY)
  2009 – 2011
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  General surgery
- Research Institution
  Gunma University
The role of calcium permeable TRPV channels in cancer cells metastasis and invasion.Principal Investigator
- Principal Investigator
  
  NAGASAWA Masahiro
- Project Period (FY)
  2007 – 2008
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  General surgery
- Research Institution
  Gunma University
Regenerative Medicine for the Type 2 Diabetes
- Principal Investigator
  
  KOJIMA Itaru
- Project Period (FY)
  2003 – 2004
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Metabolomics
- Research Institution
  Gunma University
Analysis of calcium channels roles in cancer cells proliferationPrincipal Investigator
- Principal Investigator
  
  NAGASAWA Masahiro
- Project Period (FY)
  2003 – 2004
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  General surgery
- Research Institution
  Gunma University

All 2017 2016 2015 2013 2012 2011 2010 2009 2008 2007 Other

All Journal Article Presentation Book

[Book] Mammalian Transient Receptor Potential (TRP) Cation Channels Volume1 PartⅡ The TRPV Subfamily TRPV22015
- Author(s)
  Kojima I. and Nagasawa M
- Publisher
  Springer
- Data Source
  KAKENHI-PROJECT-24591865
[Book] Mammalian Transient Receptor Potential (TRP) Cation Channels Volume1 PartⅡ The TRPV Subfamily TRPV22015
- Author(s)
  Kojima I. and Nagasawa M
- Publisher
  Springer
- Data Source
  KAKENHI-PROJECT-15K10019
[Journal Article] T1R3 homomeric sweet taste receptor regulates adipogenesis through Gαs-mediated microtubules disassembly and Rho activation in 3T3-L1 cells.2017
- Author(s)
  Masubuchi Y, Nakagawa Y, Medina J, Nagasawa M, Kojima I, Rasenick MM, Inagaki T, Shibata H.
- Journal Title
  
  PLoS One.
  
  Volume: 12 Issue: 7 Pages: e0181293-e0181293
- DOI
  10.1371/journal.pone.0181293
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15K10019
[Journal Article] TRPV2 activation requires interaction with the actin cytoskeleton and enhances growth cone motility.2017
- Author(s)
  Sugio S, Nagasawa M, Kojima I, Ishizaki Y, Shibasaki K
- Journal Title
  
  FASEB J.
  
  Volume: 31 Issue: 4 Pages: 1368-1381
- DOI
  10.1096/fj.201600686rr
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PLANNED-15H05934, KAKENHI-PROJECT-15H03000, KAKENHI-PROJECT-15K10019
[Journal Article] T1R3 homomeric sweet taste receptor regulates adipogenesis through Gas-mediated microtubules disassembly and Rho activation in 3T3-L1 cells2017
- Author(s)
  Y. Masubuchi, Y. Nakagawa, J. Medina, M. Nagasawa, I. Kojima, M. M. Rasenick, T. Inagaki, H. Shibata
- Journal Title
  
  PLOS ONE
  
  Volume: - Issue: 5 Pages: e0176841-e0176841
- DOI
  10.1371/journal.pone.0176841
- Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26461325, KAKENHI-PROJECT-15K10019, KAKENHI-PROJECT-25291002, KAKENHI-PROJECT-17H03631
[Journal Article] Positive Allosteric Modulation of the Calcium-sensing Receptor by Physiological Concentrations of Glucose.2016
- Author(s)
  Medina J, Nakagawa Y, Nagasawa M, Fernandez A, Sakaguchi K, Kitaguchi T, Kojima I.
- Journal Title
  
  J Biol Chem
  
  Volume: 291 Issue: 44 Pages: 23126-23135
- DOI
  10.1074/jbc.m116.729863
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K10019
[Journal Article] Glucose-Sensing Receptor T1R3: A New Signaling Receptor Activated by Glucose in Pancreatic β-Cells.2015
- Author(s)
  Kojima I, Nakagawa Y, Hamano K, Medina J, Li L, Nagasawa M.
- Journal Title
  
  Biol Pharm Bull.
  
  Volume: 5 Pages: 674-9
- NAID
  130005068103
- Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-24591865
[Journal Article] Glucose-Sensing Receptor T1R3: A New Signaling Receptor Activated by Glucose in Pancreatic β-Cells.2015
- Author(s)
  Kojima I, Nakagawa Y, Hamano K, Medina J, Li L, Nagasawa M.
- Journal Title
  
  Biol Pharm Bull
  
  Volume: 5 Pages: 674-9
- NAID
  130005068103
- Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K10019
[Journal Article] Translocation of TRPV2 channel induced by focal administration of mechanical stress.2015
- Author(s)
  Nagasawa M, Kojima I.
- Journal Title
  
  Physiol Reports
  
  Volume: 3
- Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K10019
[Journal Article] Translocation of TRPV2 channel induced by focal administration of mechanical stress.2015
- Author(s)
  Nagasawa M, Kojima I.
- Journal Title
  
  Physiol Rep.
  
  Volume: 3
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-24591865
[Journal Article] Glucose Evokes Rapid Ca2+ and Cyclic AMP Signals by Activating the Cell-Surface Glucose-Sensing Receptor in Pancreatic β-Cells.2015
- Author(s)
  Nakagawa Y, Nagasawa M, Medina J, Kojima I.
- Journal Title
  
  PLoS One.
  
  Volume: 12
- Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-24591865
[Journal Article] Return of the glucoreceptor: Glucose activates the glucose-sensing receptor T1R3 and facilitates metabolism in pancreatic β-cells.2015
- Author(s)
  Kojima I, Nakagawa Y, Ohtsu Y, Hamano K, Medina J, Nagasawa M.
- Journal Title
  
  J Diabetes Investig
  
  Volume: 3 Pages: 256-63
- Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K10019
[Journal Article] Return of the glucoreceptor: Glucose activates the glucose-sensing receptor T1R3 and facilitates metabolism in pancreatic β-cells.2015
- Author(s)
  Kojima I, Nakagawa Y, Ohtsu Y, Hamano K, Medina J, Nagasawa M
- Journal Title
  
  J Diabetes Investig.
  
  Volume: 3 Pages: 256-63
- Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-24591865
[Journal Article] Translocation of TRPV2 channel induced by focal administration of mechanical stress.2015
- Author(s)
  Nagasawa M, Kojima I.
- Journal Title
  
  Physiol Rep
  
  Volume: 3
- Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-24591865
[Journal Article] Glucose Evokes Rapid Ca2+ and Cyclic AMP Signals by Activating the Cell-Surface Glucose-Sensing Receptor in Pancreatic β-Cells.2015
- Author(s)
  Nakagawa Y, Nagasawa M, Medina J, Kojima I.
- Journal Title
  
  PLoS One.
  
  Volume: 12
- Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K10019
[Journal Article] Translocation of calciumpermeable TRPV2 channel to the podosome : Its role in the regulation of podosome assembly2012
- Author(s)
  長澤雅裕
- Journal Title
  
  Cell Calcium
  
  Volume: 51 Issue: 2 Pages: 186-193
- DOI
  10.1016/j.ceca.2011.12.012
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21591627
[Journal Article] Translocation of calcium-permeable TRPV2 channel to the podosome : Its role in the regulation of podosome assembly2012
- Author(s)
  Nagasawa, M and Kojimam, I
- Journal Title
  
  Cell Calcium
  
  Volume: 51 Pages: 186-193
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21591627
[Journal Article] Sweet Taste Receptor Expressed in Pancreatic beta-Cells Activates the Calcium and Cyclic AMP Signaling Systems and Stimulates Insulin Secretion2010
- Author(s)
  Nakagawa Y, Nagasawa M, Yamada S, Hara A, Mogami H, Nikolaev VO, Lohse MJ, Shigemura N, Ninomiya Y, Kojima I
- Journal Title
  
  PLOS One
  
  Volume: 4 Pages: 5106-5106
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21591627
[Journal Article] Regulation of Calcium-Permeable TRPV2 Channel by Insulin in Pancreatic beta-Cells2009
- Author(s)
  Hisanaga E, Nagasawa M, Ueki K, Kulkarni RN, Mori M, Kojima I
- Journal Title
  
  Diabetes
  
  Volume: 58 Pages: 174-184
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21591627
[Journal Article] Microtubule Disruption with BAPTA and Dimethyl BAPTA by a Calcium Chelation-Independent Mechanism in 3T3-L1 Adipocytes2009
- Author(s)
  Furuta A, Tanaka M, Omata W, Nagasawa M, Kojima I, Shibata H
- Journal Title
  
  Endocrine J
  
  Volume: 56 Pages: 235-243
- NAID
  10026913018
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21591627
[Presentation] 膵β細胞に発現するグルコース感知受容体2015
- Author(s)
  小島至、ヨハン・メディナ、中川祐子、濱野邦久、長澤雅裕
- Organizer
  生理学研究所研究会「生体シグナルダイナミクス」
- Place of Presentation
  国立生理研研究所(愛知県岡崎市）
- Year and Date
  2015-09-03
- Data Source
  KAKENHI-PROJECT-15K10019
[Presentation] 膵β細胞に発現するグルコース感知受容体2015
- Author(s)
  小島至、ヨハン・メディナ、中川祐子、濱野邦久、長澤雅裕
- Organizer
  生理学研究所研究会「生体シグナルダイナミクス」
- Place of Presentation
  生理研研究所(愛知県岡崎市）
- Year and Date
  2015-09-03
- Data Source
  KAKENHI-PROJECT-24591865
[Presentation] 機械受容チャネルTRPV2の制御機構2013
- Author(s)
  長澤　雅裕　小島　至
- Organizer
  第9回TRPチャネル研究会
- Place of Presentation
  岡崎カンファレンスセンター
- Data Source
  KAKENHI-PROJECT-24591865
[Presentation] がん細胞に発現するTRPV2:機械刺激に対する応答2012
- Author(s)
  長澤　雅裕　小島　至
- Organizer
  第8回TRPチャネル研究会
- Place of Presentation
  岡崎カンファレンスセンター
- Data Source
  KAKENHI-PROJECT-24591865
[Presentation] 膵内分泌細胞の分化におけるTRPV2チャネルの役割2011
- Author(s)
  小島至, 山田聡子, 小寺力, 中川祐子, 長澤雅裕
- Organizer
  第7回TRPチャネル研究会
- Place of Presentation
  岡崎カンファレンスセンター
- Data Source
  KAKENHI-PROJECT-21591627
[Presentation] 細胞接着・細胞運動とTRPV2機能制御2010
- Author(s)
  長澤雅裕, 小島至
- Organizer
  第6回TRPチャネル研究会
- Place of Presentation
  岡崎カンファレンスセンター
- Data Source
  KAKENHI-PROJECT-21591627
[Presentation] がん細胞の遊走とTRPV2機能2009
- Author(s)
  長澤雅裕, 中川祐子, 小島至
- Organizer
  第5回TRP研究会
- Place of Presentation
  岡崎カンファレンスセンター
- Data Source
  KAKENHI-PROJECT-21591627
[Presentation] TRPV2 による細胞骨格・細胞運動の制御2008
- Author(s)
  長澤雅裕, 小島至, 中川祐子
- Organizer
  第4回 TRPチャネル研究会
- Place of Presentation
  岡崎カンファレンスセンター
- Data Source
  KAKENHI-PROJECT-19591472
[Presentation] マクロファージにおけるTRPV2チャネルの生理的機能2007
- Author(s)
  長澤雅裕, 中川祐子, 小島至
- Organizer
  平成19年度生理学研究所研究会細胞機能を制御するシグナリング機構の普遍性と特異性
- Place of Presentation
  岡崎カンファレンスセンター
- Data Source
  KAKENHI-PROJECT-19591472
[Presentation] TRPV2
- Author(s)
  長澤　雅裕、小島　至
- Organizer
  第１０回TRP研究会
- Place of Presentation
  岡崎カンファレンスセンター
- Year and Date
  2014-06-05 – 2014-06-06
- Data Source
  KAKENHI-PROJECT-24591865

1. KOJIMA Itaru (60143492)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
2. 柴崎貢志

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
3. 柴田宏

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

NAGASAWA Masahiro 長澤 雅裕

Research Projects

Research Products

Co-Researchers

The regulation of focal mechanical stress on the localization of TRPV2 was investigated in the fibrosarcoma cells.Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

The effect of focal mechanical stress on the localization of TRPV2 was investigated in the fibrosarcoma cells.Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

The role of TRPV2 channel trafficking in cancer cell adhesion and motilityPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

The role of calcium permeable TRPV channels in cancer cells metastasis and invasion.Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Regenerative Medicine for the Type 2 Diabetes

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Analysis of calcium channels roles in cancer cells proliferationPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Book] Mammalian Transient Receptor Potential (TRP) Cation Channels Volume1 PartⅡ The TRPV Subfamily TRPV22015

Author(s)

Publisher

Data Source

[Book] Mammalian Transient Receptor Potential (TRP) Cation Channels Volume1 PartⅡ The TRPV Subfamily TRPV22015

Author(s)

Publisher

Data Source

[Journal Article] T1R3 homomeric sweet taste receptor regulates adipogenesis through Gαs-mediated microtubules disassembly and Rho activation in 3T3-L1 cells.2017

Author(s)

Journal Title

DOI

Data Source

[Journal Article] TRPV2 activation requires interaction with the actin cytoskeleton and enhances growth cone motility.2017

Author(s)

Journal Title

DOI

Data Source

[Journal Article] T1R3 homomeric sweet taste receptor regulates adipogenesis through Gas-mediated microtubules disassembly and Rho activation in 3T3-L1 cells2017

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Positive Allosteric Modulation of the Calcium-sensing Receptor by Physiological Concentrations of Glucose.2016

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Glucose-Sensing Receptor T1R3: A New Signaling Receptor Activated by Glucose in Pancreatic β-Cells.2015

Author(s)

Journal Title

NAID

Data Source

[Journal Article] Glucose-Sensing Receptor T1R3: A New Signaling Receptor Activated by Glucose in Pancreatic β-Cells.2015

Author(s)

Journal Title

NAID

Data Source

[Journal Article] Translocation of TRPV2 channel induced by focal administration of mechanical stress.2015

Author(s)

NAGASAWA Masahiro 長澤雅裕