KASAHARA Takaoki 笠原和起

Researcher Number	50344031
Other IDs
Affiliation *help	2018 : 国立研究開発法人理化学研究所, 脳神経科学研究センター, 副チームリーダー 2016 – 2017 : 国立研究開発法人理化学研究所, 脳科学総合研究センター, 副チームリーダー 2013 : 独立行政法人理化学研究所, 脳科学総合研究センター, 副チームリーダー 2011 – 2012 : 独立行政法人理化学研究所, 精神疾患動態研究チーム, 副チームリーダー 2011 : 理化学研究所, 精神疾患動態研究チーム, 副チームリーグー … More
Review Section/Research Field	Principal Investigator Psychiatric science / Animal physiology/Animal behavior / Functional biochemistry / Complex systems Except Principal Investigator Psychiatric science
Keywords	Principal Investigator メラトニン / 双極性障害 / 気分障害 / ミトコンドリア / 動物モデル / 松果体 / モデルマウス / リチウム / 概日リズム / 躁うつ病 … More Except Principal Investigator 脳・神経 / バイオテクノロジー / ゲノム / 双極性障害 / 脳神経疾患 / 神経科学 Less

Role of paraventricular thalamic nucleus in bipolar disorderOngoing
- Principal Investigator
  
  加藤忠史
- Project Period (FY)
  2017 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  Psychiatric science
- Research Institution
  Institute of Physical and Chemical Research
松果体ホルモン・メラトニンの挙動を制御する分子機序Principal InvestigatorOngoing
- Principal Investigator
  
  笠原和起
- Project Period (FY)
  2016 – 2017
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Animal physiology/Animal behavior
- Research Institution
  Institute of Physical and Chemical Research
気分障害発症における思春期早発の影響Principal Investigator
- Principal Investigator
  
  笠原和起
- Project Period (FY)
  2012 – 2013
- Research Category
  
  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
- Review Section
  
  Complex systems
- Research Institution
  The Institute of Physical and Chemical Research
Mood episode-dependent metabolome analysis of bipolar disorder model micePrincipal Investigator
- Principal Investigator
  
  KASAHARA Takaoki
- Project Period (FY)
  2011
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Psychiatric science
- Research Institution
  The Institute of Physical and Chemical Research
Physiological significance of melatonin and its precursor in mammalsPrincipal Investigator
- Principal Investigator
  
  KASAHARA Takaoki
- Project Period (FY)
  2011 – 2013
- Research Category
  
  Grant-in-Aid for Young Scientists (A)
- Research Field
  
  Animal physiology/Animal behavior
- Research Institution
  The Institute of Physical and Chemical Research
Behavioral physiological and molecular biological analyses of animal model for bipolar disorderPrincipal Investigator
- Principal Investigator
  
  KASAHARA Takaoki
- Project Period (FY)
  2008 – 2009
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Psychiatric science
- Research Institution
  The Institute of Physical and Chemical Research
遺伝子改変マウスを用いた双極性障害モデル動物の作出と実証Principal Investigator
- Principal Investigator
  
  笠原和起
- Project Period (FY)
  2005 – 2006
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Psychiatric science
- Research Institution
  The Institute of Physical and Chemical Research
第三の酸化還元補酵素を利用する新規酵素の同定と機能解析Principal Investigator
- Principal Investigator
  
  笠原和起
- Project Period (FY)
  2002 – 2003
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Functional biochemistry
- Research Institution
  The Institute of Physical and Chemical Research

All 2013 2012 2011 2010 2009 2008 2006 Other

All Journal Article Presentation Book

[Book] 精神科臨床リュミエール16巻(共著)「生物リズムと脳」2010
- Author(s)
  笠原和起
- Publisher
  中山書店(印刷中)
- Data Source
  KAKENHI-PROJECT-20790864
[Book] 精神科臨床リュミエール
- Author(s)
  笠原和起
- Total Pages
  16
- Publisher
  中山書店
- Data Source
  KAKENHI-PROJECT-20790864
[Journal Article] 松果体2013
- Author(s)
  笠原和起
- Journal Title
  
  分子精神医学
  
  Volume : 13 Pages : 212-217
- Data Source
  KAKENHI-PUBLICLY-24118510
[Journal Article] 松果体2013
- Author(s)
  笠原和起
- Journal Title
  
  分子精神医学
  
  Volume : 13 Pages : 212-217
- Data Source
  KAKENHI-PROJECT-23687010
[Journal Article] 松果体2013
- Author(s)
  笠原和起
- Journal Title
  
  分子精神医学（先端医学社）
  
  Volume : 13
- Data Source
  KAKENHI-PROJECT-23687010
[Journal Article]2013
- Author(s)
  笠原和起
- Journal Title
  
  松果体.分子精神医学
  
  Volume : 13 Pages : 212-217
- URL
  http://mol.medicalonline.jp/library/journal/abstract?GoodsID=ae6mopsb/2013/001303/009&name=0212-0217j
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23687010
[Journal Article] Regional variation in mitochondrial DNA copy number in mouse brain. Biochim2011
- Author(s)
  Fuke S, Kubota-Sakashita M, Kasahara T, Shigeyoshi Y, Kato T
- Journal Title
  
  Biophys. Acta
  
  Volume : 1807 Pages : 270-274
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23659569
[Journal Article] Genetic variation of melatonin productivity in laboratory mice under domestication.2010
- Author(s)
  Kasahara, T., Abe, K., Mekada, K., Yoshiki, A., Kato, T.
- Journal Title
  
  Proc. Natl. Acad. Sci. USA. 107
  
  Pages : 6412-6417
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20790864
[Journal Article] 双極性障害モデル実験動物2010
- Author(s)
  笠原和起
- Journal Title
  
  生体の科学 61
  
  Pages : 59-64
- Data Source
  KAKENHI-PROJECT-20790864
[Journal Article] 加藤忠史双極性障害モデル実験動物.2010
- Author(s)
  笠原和起
- Journal Title
  
  生体の科学 64
  
  Pages : 59-64
- Data Source
  KAKENHI-PROJECT-20790864
[Journal Article] Aberrant endoplasmic reticulum stress response in lymphoblastoid cells from patients with bipolar disorder.2009
- Author(s)
  Hayashi, A., Kasahara, T., Kametani, M., Toyota, T., Yoshikawa, T., Kato, T.
- Journal Title
  
  Int. J. Neuropsychopharmacol. 12
  
  Pages : 33-43
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20790864
[Journal Article] A marked effect of electroconvulsive stimulation on behavioral aberration of mice with neuron-specific mitochondrial DNA defects.2008
- Author(s)
  Kasahara, T., Kubota, M., Miyauchi, T., Ishiwata, M., Kato T.
- Journal Title
  
  PLoS ONE 3
  
  Pages : 1877-1877
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20790864
[Journal Article] Attenuated BDNF-induced upregulation of GABAergic markers in neurons lacking Xbp1.2008
- Author(s)
  Hayashi, A., Kasahara, T., Kametani, M., Kato, T.
- Journal Title
  
  Biochem. Biophys. Res. Commun. 376
  
  Pages : 758-763
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20790864
[Journal Article] 双極性障害におけるミトコンドリア機能障害.2008
- Author(s)
  笠原和起, 加藤忠史
- Journal Title
  
  脳と精神の医学 19
  
  Pages : 107-115
- Data Source
  KAKENHI-PROJECT-20790864
[Journal Article] PQQビタミン説へのアプローチ.2008
- Author(s)
  野地なつ美, 笠原和起, 浅見忠男
- Journal Title
  
  化学と生物 46
  
  Pages : 339-345
- Data Source
  KAKENHI-PROJECT-20790864
[Journal Article] Behavioral and gene expression analyses of Wfs1 knockout mice as a possible animal model of mood disorder.2008
- Author(s)
  Kato, T., Ishiwata, M., Yamada, K., Kasahara T., Kakiuchi, C., Iwamoto, K., Kawamura, K., Ishihara, H., Oka, Y.
- Journal Title
  
  Neurosci. Res. 61
  
  Pages : 143-153
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20790864
[Journal Article] A marked effect of electroconvulsive stimulation on behavioral aberration of mice with neuron-specific mitochondrial DNA defects2008
- Author(s)
  T. Kasahara
- Journal Title
  
  PLoS ONE 3
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20790864
[Journal Article] Mice with neuron-specific accumulation of mitochondrial DNA mutations show mood disorder-like phenotypes.2006
- Author(s)
  Kasahara, T.
- Journal Title
  
  Molecular Psychiatry 11・6
  
  Pages : 577-593
- Data Source
  KAKENHI-PROJECT-17790830
[Journal Article] Therapeutic implications of down-regulation of cyclophilin D in bipolar disorder.
- Author(s)
  Kubota, M., Kasahara, T., Iwamoto, K., Komori, A., Ishiwata, M., Miyauchi, T., Kato, T.
- Journal Title
  
  Int. J. Neuropsychopharmacol. (in press)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20790864
[Journal Article] 気分障害薬物療法の脳科学.
- Author(s)
  笠原和起
- Journal Title
  
  精神科 (印刷中)
- Data Source
  KAKENHI-PROJECT-20790864
[Presentation] Molecular and genetic characterization of the mouse pseudoautosomal region2013
- Author(s)
  Takaoki Kasahara, Kuniya Abe, Tadafumi Kato
- Organizer
  Mouse Molecular Genetics 2013
- Place of Presentation
  WellcomeTrust Genome Campus（イギリス・ケンブリッジ）
- Data Source
  KAKENHI-PROJECT-23687010
[Presentation] Molecular and genetic characterization of the mouse pseudoautosomal region2013
- Author(s)
  Takaoki Kasahara, Kuniya Abe, Tadafumi Kato
- Organizer
  Mouse Molecular Genetics 2013
- Place of Presentation
  英国・ケンブリッジ
- Year and Date
  2013-09-20
- Data Source
  KAKENHI-PROJECT-23687010
[Presentation] Identification of mouse Hiomt gene and development of melatonin-proficient congenic C57BL/6J mice2012
- Author(s)
  Takaoki Kasahara, Kuniya Abe, Kazuyuki Mekada, Atsushi Yoshiki, Shigeharu Wakana, Tadafumi Kato
- Organizer
  Gordon Research Conference : Pineal Cell Biology
- Place of Presentation
  ガルベストン(米国)
- Year and Date
  2012-02-01
- Data Source
  KAKENHI-PROJECT-23687010
[Presentation] 気分障害の生物学的アプローチ2012
- Author(s)
  笠原和起
- Organizer
  第116回日本眼科学会総会
- Place of Presentation
  東京
- Year and Date
  2012-04-06
- Data Source
  KAKENHI-PROJECT-23659569
[Presentation] Tadafumi Kato. Identification of mouse Hiomt gene and development of melatonin-proficient congenic C57BL/6J mice2012
- Author(s)
  Takaoki Kasahara, Kuniya Abe, Kazuyuki Mekada, Atsushi Yoshiki, Shigeharu Wakana, Tadafumi Kato
- Organizer
  Gordon Research Conference : Pineal Cell Biology
- Place of Presentation
  米国・ガルベストン
- Year and Date
  2012-02-01
- Data Source
  KAKENHI-PROJECT-23687010
[Presentation] Development and characterization of a mouse model for mood disorde2012
- Author(s)
  Takaoki Kasahara
- Organizer
  Infrafrontier/IMPC Korea Meeting
- Place of Presentation
  韓国・ソギッポ
- Year and Date
  2012-09-26
- Invited
- Data Source
  KAKENHI-PROJECT-23687010
[Presentation] Development and characterization of a mouse model for mood disorder2012
- Author(s)
  Takaoki Kasahara
- Organizer
  Infrafrontier / IMPC Korea Meeting
- Place of Presentation
  韓国・ソギィポ
- Year and Date
  2012-09-26
- Invited
- Data Source
  KAKENHI-PUBLICLY-24118510
[Presentation] 気分障害の生物学的アプローチ2012
- Author(s)
  笠原和起
- Organizer
  第116回日本眼科学会総会
- Place of Presentation
  東京
- Year and Date
  2012-04-06
- Invited
- Data Source
  KAKENHI-PUBLICLY-24118510
[Presentation] A Possible Role of Mitochondrial Dysfunction in Bipolar Disorder : from Genetics to Animal Model2011
- Author(s)
  Takaoki Kasahara, Tadafumi Kato
- Organizer
  The American College of Neuropsychopharmacology第50回年会
- Place of Presentation
  米国ハワイ州ワイコロア
- Year and Date
  2011-12-08
- Data Source
  KAKENHI-PROJECT-23659569
[Presentation] マウス偽常染色体領域のDNAシーケンシング2011
- Author(s)
  笠原和起
- Organizer
  第25回モロシヌス研究会
- Place of Presentation
  ベルナティオ(新潟県)
- Year and Date
  2011-07-09
- Data Source
  KAKENHI-PROJECT-23687010
[Presentation] マウスの飼育舎内「進化」～メラトニン合成能を例に～2011
- Author(s)
  笠原和起
- Organizer
  実験動物学会第58回総会
- Place of Presentation
  タワーホール船堀(東京都)(招待講演)
- Year and Date
  2011-05-25
- Data Source
  KAKENHI-PROJECT-23687010
[Presentation] Sequencing of mouse pseudoautosomal region2011
- Author(s)
  Takaoki Kasahara, Kuniya Abe, Tadafumi Kato
- Organizer
  International Mammalian Genome Society、Complex Trait Consortium, The Genetics Society of Americaの合同総会(Mouse Genetics 2011)
- Place of Presentation
  ワシントンDC(米国)
- Year and Date
  2011-06-24
- Data Source
  KAKENHI-PROJECT-23687010
[Presentation] マウスの飼育舎内「進化」～メラトニン合成能を例に～2011
- Author(s)
  笠原和起
- Organizer
  実験動物学会第58回総会
- Place of Presentation
  東京都
- Year and Date
  2011-05-25
- Invited
- Data Source
  KAKENHI-PROJECT-23687010
[Presentation] Sequencing of mouse pseudoautosomal region.2011
- Author(s)
  Takaoki Kasahara, Kuniya Abe, Tadafumi Kato
- Organizer
  Mouse Genetics 2011
- Place of Presentation
  米国・ワシントンDC
- Year and Date
  2011-06-24
- Data Source
  KAKENHI-PROJECT-23687010
[Presentation] マウス偽常染色体領域のDNAシーケンシング2011
- Author(s)
  笠原和起
- Organizer
  第25回モロシヌス研究会
- Place of Presentation
  新潟県
- Year and Date
  2011-07-09
- Data Source
  KAKENHI-PROJECT-23687010
[Presentation] 変異Polg1トランスジェニックマウスが示す気分障害類似の表現型の詳細な解析2011
- Author(s)
  笠原和起,窪田美恵,石渡みずほ,亀谷瑞枝,磯野蕗子,加藤忠史
- Organizer
  第33回日本生物学的精神医学会
- Place of Presentation
  東京
- Year and Date
  2011-05-21
- Data Source
  KAKENHI-PROJECT-23659569
[Presentation] マウスのメラトニン合成能の飼育舎内進化2009
- Author(s)
  笠原和起
- Organizer
  第23回モロシヌス研究会
- Place of Presentation
  守山
- Year and Date
  2009-07-11
- Data Source
  KAKENHI-PROJECT-20790864
[Presentation] 複数の遺伝的負因を持つ双極性障害モデルマウスの開発2009
- Author(s)
  笠原和起
- Organizer
  第31回日本生物学的精神医学会
- Place of Presentation
  京都
- Year and Date
  2009-04-23
- Data Source
  KAKENHI-PROJECT-20790864
[Presentation] Mouse models for bipolar disorder based on rare hereditary diseases2009
- Author(s)
  笠原和起
- Organizer
  第32回日本神経科学大会
- Place of Presentation
  名古屋
- Year and Date
  2009-09-18
- Data Source
  KAKENHI-PROJECT-20790864
[Presentation] Identification of mouse HIOMT gene2009
- Author(s)
  笠原和起
- Organizer
  Gordon Research Conference(Chronobiology)
- Place of Presentation
  米国・ニューポート
- Year and Date
  2009-07-19
- Data Source
  KAKENHI-PROJECT-20790864
[Presentation] Mouse models for bipolar disorder based on rare hereditary diseases.2009
- Author(s)
  Kasahara, T.
- Organizer
  第32回日本神経科学大会
- Place of Presentation
  名古屋
- Data Source
  KAKENHI-PROJECT-20790864
[Presentation] マウスのメラトニン合成能の飼育舎内進化2009
- Author(s)
  笠原和起, 阿部訓也, 加藤忠史
- Organizer
  第23回モロシヌス研究会
- Place of Presentation
  守山
- Data Source
  KAKENHI-PROJECT-20790864
[Presentation] Identification of mouse HIOMT gene.2009
- Author(s)
  Kasahara, T., Kato, T.
- Organizer
  Gordon Research Conference
- Place of Presentation
  ニューポート, 米国
- Data Source
  KAKENHI-PROJECT-20790864
[Presentation] 複数の遺伝的負因を持つ双極性障害モデルマウスの開発.2009
- Author(s)
  笠原和起, 石渡みずほ, 宮内妙子, 山田一之, 垣内千尋, 川村光毅, 石原寿光, 岡芳知, 加藤忠史
- Organizer
  第31回日本生物学的精神医学会
- Place of Presentation
  富山
- Data Source
  KAKENHI-PROJECT-20790864
[Presentation] Mitochondrial Dysfunction in Bipolar Disorder2008
- Author(s)
  T. Kasahara
- Organizer
  The 2nd WFSBP Asia-Pacific Cogress
- Place of Presentation
  富山
- Year and Date
  2008-09-11
- Data Source
  KAKENHI-PROJECT-20790864
[Presentation] Transgenic mice with neuron-specific mitochondrial DNA defects as a model for bipolar disorderT. Kasahara2008
- Author(s)
  T. Kasahara
- Organizer
  The seventh European Meeting on Mitochondrial Pathology(EUEOMIT7)
- Place of Presentation
  ストックホルム(スウェーデン)
- Year and Date
  2008-06-12
- Data Source
  KAKENHI-PROJECT-20790864
[Presentation] 双極性障害のミトコンドリア機能障害仮説に基づいたモデル動物が示す異常行動とそれに対する治療効果.2008
- Author(s)
  笠原和起, 窪田美恵, 宮内妙子, 石渡みずほ, 加藤忠史
- Organizer
  第27回躁うつ病の薬理・生化学的研究懇話会
- Place of Presentation
  箱根
- Data Source
  KAKENHI-PROJECT-20790864
[Presentation] Transgenic mice with neuron-specific mitochondrial DNA defects as a model for bipolar disorder.2008
- Author(s)
  Kasahara, T., Kubota, M., Miyauchi, T., Ishiwata, M., Kato, T.
- Organizer
  Euromit7
- Place of Presentation
  ストックホルム, スウェーデン
- Data Source
  KAKENHI-PROJECT-20790864
[Presentation] Mitochondrial Dysfunction in Bipolar Disorder.2008
- Author(s)
  Kasahara, T., Kato, T.
- Organizer
  2nd World Federation of Societies of Biological Psychiatry Asia-Pacific Congress・第30回日本生物学的精神医学会
- Place of Presentation
  富山
- Data Source
  KAKENHI-PROJECT-20790864
[Presentation] Episodic behavioral change in mutant Polg1 transgenic mice meets clinical diagnostic criteria for major depressive episode.
- Author(s)
  Takaoki Kasahara, Mizue Kametani, Mizuho Ishiwata, Fumiko Isono, Tadafumi Kato
- Organizer
  Neuro2013
- Place of Presentation
  京都国際会館（京都府）
- Invited
- Data Source
  KAKENHI-PUBLICLY-24118510
[Presentation] Mice with neuron-specific accumulation of mtDNA deletions, the DSM-5- validated animal model for mood disorder.
- Author(s)
  Takaoki Kasahara, Tadafumi Kato
- Organizer
  16th Annual Conference of the International Society for Bipolar Disorders
- Place of Presentation
  COEX Convention & Exhibition Center（韓国・ソウル）
- Invited
- Data Source
  KAKENHI-PUBLICLY-24118510
[Presentation] DSM-based assessment of episodic behavioral change in mutant Polg1 transgenic mice.
- Author(s)
  Takaoki Kasahara, Mizue Kametani, Mizuho Ishiwata, Fumiko Isono, Tadafumi Kato
- Organizer
  11th World congress of Biological Psychiatry
- Place of Presentation
  京都国際会館（京都府）
- Invited
- Data Source
  KAKENHI-PUBLICLY-24118510
[Presentation] Development and characterization of a mouse model for mood disorder
- Author(s)
  Takaoki Kasahara
- Organizer
  Infrafrontier / IMPC Korea Meeting
- Place of Presentation
  韓国・ソギィポ
- Invited
- Data Source
  KAKENHI-PROJECT-23687010

1. 加藤忠史 (30214381)

# of Collaborated Projects : 1results

# of Collaborated Products : 0results
2. 窪田美恵 (90344035)

# of Collaborated Projects : 1results

# of Collaborated Products : 0results

KASAHARA Takaoki 笠原 和起

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Co-Researchers

Role of paraventricular thalamic nucleus in bipolar disorderOngoing

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松果体ホルモン・メラトニンの挙動を制御する分子機序Principal InvestigatorOngoing

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気分障害発症における思春期早発の影響Principal Investigator

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Mood episode-dependent metabolome analysis of bipolar disorder model micePrincipal Investigator

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Physiological significance of melatonin and its precursor in mammalsPrincipal Investigator

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Behavioral physiological and molecular biological analyses of animal model for bipolar disorderPrincipal Investigator

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遺伝子改変マウスを用いた双極性障害モデル動物の作出と実証Principal Investigator

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第三の酸化還元補酵素を利用する新規酵素の同定と機能解析Principal Investigator

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[Book] 精神科臨床リュミエール16巻(共著)「生物リズムと脳」2010

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[Book] 精神科臨床リュミエール

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[Journal Article] 松果体2013

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[Journal Article] 松果体2013

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[Journal Article] 松果体2013

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Data Source

[Journal Article]2013

Author(s)

Journal Title

URL

Data Source

[Journal Article] Regional variation in mitochondrial DNA copy number in mouse brain. Biochim2011

Author(s)

KASAHARA Takaoki 笠原和起