Hara Masayuki 原正之

… Alternative Names

原正之ハラマサユキ

HARA Masayuki 原正之

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Researcher Number	50344172
Other IDs
External Links
Affiliation (Current)	2023: 大阪公立大学, 大学院理学研究科 , 教授
Affiliation (based on the past Project Information) *help	2022: 大阪公立大学, 大学院理学研究科, 教授 2011 – 2016: 大阪府立大学, 理学(系)研究科(研究院), 教授 2007: Oasaka Prefecture Universty, Graduate School of Sciences, Professor 2006: 大阪府立大学, 理学研究科, 教授 2005: Osaka Prefecture University, Graduate School of Sciences, Professor, 理学系研究科, 教授 … More 2004: 大阪府立大学, 先端科学研究所, 教授 2003: 大阪府立大学, 先端科学研究所・応用生体科学部門人工生体組織研究分野, 教授 2002: 大阪府立大学, 先端科学研究所・応用生体科学部門・人口生体組織研究分野, 教授 Less
Review Section/Research Field	Principal Investigator Biofunction/Bioprocess / Biofunction/Bioprocess / Basic Section 27040:Biofunction and bioprocess engineering-related Except Principal Investigator Nuclear engineering / Cerebral neurosurgery / Biofunction/Bioprocess
Keywords	Principal Investigator 間葉系幹細胞 / 光増感色素 / 細胞分化 / 神経幹細胞 / 細胞分離技術 / PDT / 細胞死 / 活性酸素 / 神経幹・前駆細胞 / apoptosis … More / 神経細胞 / グリア細胞 / ABC transporter / necrosis / mesenchymal stem cell / bone / photosensitizer / hematorporphyrin / rhodamine / reative oxygen species / hematoporphyrin / reactive oxygen species / 活性酸素種 / ヘマトポルフィリン … More Except Principal Investigator 神経幹細胞 / ナノ材料 / 感温性 / ポリペプチド / 放射線架橋 / ヒト神経幹細胞 / 低酸素ストレス / 乳酸脱水素酵素 / ピルビン酸脱水素酵素 / 神経前駆細胞 / ヒト細胞 / 多分化能 / 細胞倍加速度 / レチノイン酸 / BDNF / neural stem cell / viscoelasiticity / collagen gel / endothelial cell / UV-irradiation / cell patterning / コラーゲン / 血管内皮細胞 / 紫外線照射 / ハイドロゲル / 粘弾性 / パターニング / パターンニング / 下限臨界温度 / エラスチン / ナノ粒子 / DDS / nano material / thermosensitivity / polypeptide / LCST / radiation crosslinking / Nano materials / Thermosensitivity / Polypeptide / Radiation Crosslinking Less

光制御活性酸素負荷による間葉系幹細胞の運命決定技術の創製Principal Investigator
- Principal Investigator
  
  原正之
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 27040:Biofunction and bioprocess engineering-related
- Research Institution
  Osaka Metropolitan University
Development of techniques for patterning of differentiating cells derived from neural stem cells
- Principal Investigator
  
  Mori Hideki
- Project Period (FY)
  2014 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Biofunction/Bioprocess
- Research Institution
  Osaka Prefecture University
Study on the system to control the proliferation and differentiation of stem cells and by moderate oxidative stress.Principal Investigator
- Principal Investigator
  
  Hara Masayuki
- Project Period (FY)
  2014 – 2015
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Biofunction/Bioprocess
- Research Institution
  Osaka Prefecture University
Method for selection of cells using photosensitizersPrincipal Investigator
- Principal Investigator
  
  HARA Masayuki
- Project Period (FY)
  2011 – 2012
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Biofunction/Bioprocess
- Research Institution
  Osaka Prefecture University
Fabrication of Nanoparticles by Gamma-ray crosslinking of thermosensitive polypeptides and analysis for controled release of drugs
- Principal Investigator
  
  FURUTA Masakazu
- Project Period (FY)
  2006 – 2007
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Nuclear engineering
- Research Institution
  Osaka Prefecture University
Design of nano-particle type drug delivery system with thermosensitive bioelastic polypeptides by radiation crosslinking
- Principal Investigator
  
  FURUTA Masakazu
- Project Period (FY)
  2004 – 2005
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Nuclear engineering
- Research Institution
  Osaka Prefecture University
正常ヒト神経幹細胞由来神経細胞における、低酸素状態下での遺伝子制御システムの解明
- Principal Investigator
  
  金村米博
- Project Period (FY)
  2002 – 2003
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  Cerebral neurosurgery
- Research Institution
  National Institute of Advanced Industrial Science and Technology

All 2017 2016 2015 2014 2013 2012 2011 2006 2005 2004 Other

All Journal Article Presentation Patent

[Journal Article] Analysis of ZIP (Zrt-, Irt-related protein) transporter gene expression in murine neural　stem/progenitor cells2017
- Author(s)
  Mayu Nishikawa, Hideki Mori, Masayuki Hara
- Journal Title
  
  Environmental Toxicology and Pharmacology
  
  Volume: -
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-26420799
[Journal Article] Clusters of neural stem/progenitor cells cultured on a soft poly(vinyl alcohol) hydrogel crosslinked by gamma irradiation2016
- Author(s)
  Hideki Mori, Masayuki Hara
- Journal Title
  
  Journal of Bioscience and Bioengineering
  
  Volume: 12 Issue: 5 Pages: 584-590
- DOI
  10.1016/j.jbiosc.2015.09.010
- NAID
  40020838937
- ISSN
  1389-1723
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-26420799
[Journal Article] Gamma-cross-linked nonfibrillar collagen gel as a scaffold for osteogenic differentiation of mesenchymal stem cells2015
- Author(s)
  Takako Takitoh, Masahiko Bessho, Motohiro Hirose, Hajime Ohgushi, Hideki Mori, Masayuki Hara
- Journal Title
  
  Journal of Bioscience and Bioengineering
  
  Volume: 119 Issue: 2 Pages: 217-225
- DOI
  10.1016/j.jbiosc.2014.07.008
- NAID
  110009922498
- ISSN
  1389-1723
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-26630435
[Journal Article] Porous hydrogel of wool keratin prepared by a novel method: an extraction with guanidine/2-mercaptoethnolsolution followed by a dialysis2014
- Author(s)
  Yuki Ozaki, Yusuke Takagi, Hideki Mori, Masayuki Hara
- Journal Title
  
  Materials Science and Engineering C
  
  Volume: 42 Pages: 146-154
- DOI
  10.1016/j.msec.2014.05.018
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-26630435
[Journal Article] Migration of glial cells differentiated from neurosphere-forming neural stem/progenitor cells depends on the stiffness of the chemically cross-linked collagen gel substrate2013
- Author(s)
  Hideki Mori, Ayumi Takahashi, Ayano Horimoto, Masayuki Hara
- Journal Title
  
  Neuroscience Letters
  
  Volume: 555 Pages: 1-6
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23656532
[Journal Article] Migration of glial cells differentiated from neurosphere-forming　neural stem/progenitor cells depends on the　stiffness of the chemically cross-linked collagen gel substrate2013
- Author(s)
  Hideki Mori, Ayumi Takahashi, Ayano Horimoto, Masayuki Hara
- Journal Title
  
  Neuroscience Letters
  
  Volume: 555 Pages: 1-6
- DOI
  10.1016/j.neulet.2013.09.012
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23656532
[Journal Article] Neural stem/progenitor cells damaged by reactive oxygen species evolved by photosensitizing reaction2011
- Author(s)
  Hideki Mori, Yosuke Yoshida, Masayuki Hara
- Journal Title
  
  Neuroscience Letters
  
  Volume: 493 Pages: 24-28
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23656532
[Journal Article] A novel collagen hydrogel cross-linked by gamma-ray irradiation in acidic pH condition2006
- Author(s)
  N.Inoue, M.Bessho, M.Furuta, T.kojima, S.Okuda, M.Hara
- Journal Title
  
  Journal of biomater.Sci.Polymer Edn. 17(8)
  
  Pages: 837-858
- Data Source
  KAKENHI-PROJECT-18560803
[Journal Article] Gelatin hydrogels cross-linked by gamma-ray irradiation : materials for absorption and release of dye,2005
- Author(s)
  M.Bessho, M.Furuta, T.Kojima, S.Okuda, M.Hara
- Journal Title
  
  Journal of Biomater.Sci.Polymer Edn. 16(6)
  
  Pages: 715-724
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16560736
[Journal Article] Pulse radiolysis system of OPU-LINAC in RIAST, Osaka Prefecture University,2004
- Author(s)
  T.Kojima, R.Taniguchi, M.Furuta, S.Okuda, M.Hara, S.Fujita
- Journal Title
  
  Radiation Physics and Chemistry 71(1-2)
  
  Pages: 603-606
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16560736
[Journal Article] Characterization of biopolymer hydrogels produced by γ-ray irradiation,2004
- Author(s)
  T.Kojima, M.Bessho, M.Furuta, S.Okuda, M.Hara
- Journal Title
  
  Radiation Physics and Chemistry 71(1-2)
  
  Pages: 235-238
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16560736
[Patent] 神経幹細胞の新規マーカー2016
- Inventor(s)
  森英樹、原正之、西川麻裕
- Industrial Property Rights Holder
  公立大学法人大阪府立大学
- Industrial Property Rights Type
  特許
- Industrial Property Number
  2016-161359
- Filing Date
  2016-08-19
- Data Source
  KAKENHI-PROJECT-26420799
[Presentation] コラーゲンゲル表面の紫外線架橋による血管内皮細胞の接着性の調節2017
- Author(s)
  森英樹、土岐麻菜、原正之
- Organizer
  第16回日本再生医療学会総会
- Place of Presentation
  仙台国際センター（宮城県・仙台市）
- Year and Date
  2017-03-07
- Data Source
  KAKENHI-PROJECT-26420799
[Presentation] Proliferation of neural stem/progenitor cells on poly (acrylic acid)-grafted polyamide fibers2016
- Author(s)
  Hideki Mori, Masayuki Hara
- Organizer
  2016年度国際幹細胞学会（ISSCR2016）
- Place of Presentation
  San Franｃisco (USA, CA)
- Year and Date
  2016-06-22
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26420799
[Presentation] ポリアミド繊維上における神経幹細胞／前駆細胞の接着と三次元的な伸展2016
- Author(s)
  森英樹、藤田雅徳、原正之
- Organizer
  第68回日本生物工学会
- Place of Presentation
  富山国際会議場（富山県・富山市）
- Year and Date
  2016-09-28
- Data Source
  KAKENHI-PROJECT-26420799
[Presentation] 間葉系幹細胞の生存と分化に対する光増感反応による酸化ストレス刺激の影響2016
- Author(s)
  城田祐介、森英樹、原正之
- Organizer
  日本化学会第96春季年会
- Place of Presentation
  同志社大学（京田辺市）
- Year and Date
  2016-03-24
- Data Source
  KAKENHI-PROJECT-26630435
[Presentation] 紫外線照射コラーゲンゲル上で培養した脳毛細血管内皮細胞におけるインテグリン遺伝子の発現解析2016
- Author(s)
  土岐麻菜、佐藤綾香、森英樹、原正之
- Organizer
  第68回日本生物工学会
- Place of Presentation
  富山国際会議場（富山県・富山市）
- Year and Date
  2016-09-28
- Data Source
  KAKENHI-PROJECT-26420799
[Presentation] 培養ラット間葉系幹細胞に対する光増感反応による活性酸素ストレスの影響2015
- Author(s)
  森　英樹、田中太陽、原　正之
- Organizer
  第３８日本分子生物学会年会・第８８回日本生化学会大会合同大会（BMB 2015）
- Place of Presentation
  神戸国際会議場(神戸市）
- Year and Date
  2015-12-01
- Data Source
  KAKENHI-PROJECT-26630435
[Presentation] Preparation of poly (vinyl alcohol) hydrogels by γ-irradiation for cluster culture of neural stem cells2015
- Author(s)
  Hideki Mori, Masayuki Hara
- Organizer
  2015 環太平洋国際化学会議（PACIFICHEM2015）
- Place of Presentation
  HAWAII CONVENTION CENTER、ハワイ（ホノルル）
- Year and Date
  2015-12-15
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26420799
[Presentation] ポリビニルアルコールゲルに接着した神経幹細胞／前駆細胞の分化関連遺伝子の発現解析2015
- Author(s)
  中村泰斗、森英樹、原正之
- Organizer
  第37回日本バイオマテリアル学会
- Place of Presentation
  京都テルサ（京都市）
- Year and Date
  2015-11-09
- Data Source
  KAKENHI-PROJECT-26420799
[Presentation] 多孔質ケラチンハイドロゲルの研究2015
- Author(s)
  村田重徳、尾崎由季、高木優輔、森英樹、原正之
- Organizer
  日本バイオマテリアル学会第１０回関西若手研究発表会
- Place of Presentation
  関西大学（吹田市）
- Year and Date
  2015-08-05
- Data Source
  KAKENHI-PROJECT-26630435
[Presentation] 培養ラット間葉系幹細胞に対する活性酸素ストレスの影響2015
- Author(s)
  森　英樹、田中太陽、原　正之
- Organizer
  第 67 回日本生物工学会大会
- Place of Presentation
  城山観光ホテル（鹿児島市）
- Year and Date
  2015-10-26
- Data Source
  KAKENHI-PROJECT-26630435
[Presentation] In vitro osteogenic differentiation of rat mesenchymal stem cells on two types of collagen gels with and without collagen fibrils2015
- Author(s)
  Takako Takitoh, Masahiko Bessho, Motohiro Hirose, Hajime Ohgushi, Hideki Mori, Masayuki Hara
- Organizer
  8th KIFEE-Symposium
- Place of Presentation
  NTNU, Trondheim, Norway (ノルウェー科学技術大学)
- Year and Date
  2015-09-23
- Data Source
  KAKENHI-PROJECT-26630435
[Presentation] 紫外線照射コラーゲンゲルに対する脳毛細血管内皮細胞の接着性の解析2015
- Author(s)
  森英樹、佐藤綾香、原正之
- Organizer
  第67回日本生物工学会大会
- Place of Presentation
  城山観光ホテル（鹿児島市）
- Year and Date
  2015-10-26
- Data Source
  KAKENHI-PROJECT-26420799
[Presentation] マウス神経幹細胞/前駆細胞のアストロサイト分化に対するカドミウム曝露の影響2014
- Author(s)
  森英樹、西川麻裕、佐々木豪、原正之
- Organizer
  第13回日本再生医療学会総会
- Place of Presentation
  京都国際会議場
- Data Source
  KAKENHI-PROJECT-23656532
[Presentation] ガンマ線架橋ポリビニルアルコールゲル上におけるマウス神経幹細胞/前駆細胞の増殖性の評価2014
- Author(s)
  森英樹、川瀬文音、大田愛里、原正之
- Organizer
  第13回日本再生医療学会総会
- Place of Presentation
  京都国際会議場
- Data Source
  KAKENHI-PROJECT-23656532
[Presentation] カドミウム曝露によるマウス神経幹細胞由来アストロサイトのGFAP局在性の変化2013
- Author(s)
  森英樹、西川麻裕、佐々木豪、原正之
- Organizer
  第65回日本生物工学会大会
- Place of Presentation
  広島国際会議場
- Data Source
  KAKENHI-PROJECT-23656532
[Presentation] マウス神経幹細胞/前駆細胞の分化による亜鉛感受性の変化2013
- Author(s)
  西川麻裕、佐々木豪、森英樹、原正之
- Organizer
  第65回日本生物工学会大会
- Place of Presentation
  広島国際会議場
- Data Source
  KAKENHI-PROJECT-23656532
[Presentation] 放射線架橋ポリビニルアルコールゲルを用いた神経幹細胞／前駆細胞の培養2013
- Author(s)
  森英樹、川瀬文音、原正之
- Organizer
  第65回日本生物工学会大会
- Place of Presentation
  広島国際会議場
- Data Source
  KAKENHI-PROJECT-23656532
[Presentation] 活性酸素による神経幹／前駆細胞の障害機構2012
- Author(s)
  森英樹、吉田陽亮、金村米博、原正之
- Organizer
  第64回日本生物工学会大会
- Place of Presentation
  神戸国際会議場（兵庫県）
- Data Source
  KAKENHI-PROJECT-23656532
[Presentation] 培養神経幹／前駆細胞に対する活性酸素の影響2012
- Author(s)
  森英樹、原正之
- Organizer
  日本化学会第9２春季年会
- Place of Presentation
  慶應義塾大学（神奈川県）
- Data Source
  KAKENHI-PROJECT-23656532
[Presentation] 培養神経幹/前駆細胞に対する活性酸素の影響2012
- Author(s)
  森英樹, 原正之
- Organizer
  日本化学会第92春季年会
- Place of Presentation
  横浜・慶応義塾大学
- Data Source
  KAKENHI-PROJECT-23656532
[Presentation] 培養神経幹／前駆細胞に対する活性酸素の影響2012
- Author(s)
  原正之、森英樹
- Organizer
  第11回日本再生医療学会総会
- Place of Presentation
  パシフィコ横浜（神奈川県）
- Data Source
  KAKENHI-PROJECT-23656532
[Presentation] Neural stem/progenitor cells damaged by reactive oxygen species evolved by photosensitizing reaction2012
- Author(s)
  Hideki Mori, Masayuki Hara
- Organizer
  International Society for Stem Cell Research (ISSCR)
- Place of Presentation
  Pacifico Yokohama
- Data Source
  KAKENHI-PROJECT-23656532
[Presentation] 活性酸素による神経幹/前駆細胞の障害機構2012
- Author(s)
  森英樹, 吉田陽亮, 金村米博, 原正之
- Organizer
  第64回日本生物工学会大会
- Place of Presentation
  神戸国際会議場
- Data Source
  KAKENHI-PROJECT-23656532
[Presentation] Neural stem/progenitor cells damaged by reactive oxygen species evolved by photosensitizing reaction2012
- Author(s)
  Hideki Mori, Masayuki Hara
- Organizer
  International Society for Stem Cell Research (ISSCR)
- Place of Presentation
  パシフィコ横浜（神奈川県）
- Data Source
  KAKENHI-PROJECT-23656532
[Presentation] Neural stem/progenitor cells damaged by reactive oxygen species2012
- Author(s)
  Hideki Mori, Masayuki Hara
- Organizer
  YABEC 2012
- Place of Presentation
  徳島大学（徳島県）
- Data Source
  KAKENHI-PROJECT-23656532
[Presentation] Neural stem/progenitor cells damaged by reactive oxygen species2012
- Author(s)
  Hideki Mori, Masayuki Hara
- Organizer
  YABEC 2012
- Place of Presentation
  徳島大学
- Data Source
  KAKENHI-PROJECT-23656532
[Presentation] 培養神経幹/前駆細胞に対する活性酸素の影響2012
- Author(s)
  原正之, 森英樹
- Organizer
  第11回日本再生医療学会総会
- Place of Presentation
  パシフィコ横浜
- Data Source
  KAKENHI-PROJECT-23656532
[Presentation] 間葉系幹細胞への光増感反応の影響評価
- Author(s)
  田中太陽、森英樹、原正之
- Organizer
  第 66 回日本生物工学会大会
- Place of Presentation
  札幌コンベンションセンター
- Year and Date
  2014-09-09 – 2014-09-11
- Data Source
  KAKENHI-PROJECT-26630435
[Presentation] Proliferation of murine neural stem/progenitor cells on polyvinyl alcohol hydrogels
- Author(s)
  Hideki Mori, Masayuki Hara
- Organizer
  International Society for Stem Cell Research　12th　Annual Meeting
- Place of Presentation
  バンクーバー (カナダ)
- Year and Date
  2014-06-18 – 2014-06-21
- Data Source
  KAKENHI-PROJECT-26420799
[Presentation] 軟質ポリビニルアルコールゲル上におけるマウス神経幹細胞／前駆細胞の接着と増殖
- Author(s)
  森英樹、原正之
- Organizer
  第87回日本生化学会大会
- Place of Presentation
  京都国際会館 (京都市)
- Year and Date
  2014-10-15 – 2014-10-18
- Data Source
  KAKENHI-PROJECT-26420799

1. MORI Hideki (30450894)

# of Collaborated Projects: 4 results

# of Collaborated Products: 37 results
2. FURUTA Masakazu (40181458)

# of Collaborated Projects: 2 results

# of Collaborated Products: 4 results
3. OKUDA Shuichi (00142175)

# of Collaborated Projects: 2 results

# of Collaborated Products: 4 results
4. OKAMOTO Kouji (40122618)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
5. 金村米博 (80344175)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. 中村徳幸 (20198229)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. 三宅正人 (60344173)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. 田村和義 (40340971)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. 有田憲生 (80159508)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results

Hara Masayuki 原 正之

原 正之 ハラ マサユキ

HARA Masayuki 原 正之

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光制御活性酸素負荷による間葉系幹細胞の運命決定技術の創製Principal Investigator

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Development of techniques for patterning of differentiating cells derived from neural stem cells

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Study on the system to control the proliferation and differentiation of stem cells and by moderate oxidative stress.Principal Investigator

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Method for selection of cells using photosensitizersPrincipal Investigator

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Fabrication of Nanoparticles by Gamma-ray crosslinking of thermosensitive polypeptides and analysis for controled release of drugs

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Design of nano-particle type drug delivery system with thermosensitive bioelastic polypeptides by radiation crosslinking

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正常ヒト神経幹細胞由来神経細胞における、低酸素状態下での遺伝子制御システムの解明

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[Journal Article] Analysis of ZIP (Zrt-, Irt-related protein) transporter gene expression in murine neural stem/progenitor cells2017

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[Journal Article] Clusters of neural stem/progenitor cells cultured on a soft poly(vinyl alcohol) hydrogel crosslinked by gamma irradiation2016

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[Journal Article] Gamma-cross-linked nonfibrillar collagen gel as a scaffold for osteogenic differentiation of mesenchymal stem cells2015

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[Journal Article] Porous hydrogel of wool keratin prepared by a novel method: an extraction with guanidine/2-mercaptoethnolsolution followed by a dialysis2014

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[Journal Article] Migration of glial cells differentiated from neurosphere-forming neural stem/progenitor cells depends on the stiffness of the chemically cross-linked collagen gel substrate2013

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[Journal Article] Migration of glial cells differentiated from neurosphere-forming neural stem/progenitor cells depends on the stiffness of the chemically cross-linked collagen gel substrate2013

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Hara Masayuki 原正之

原正之ハラマサユキ

HARA Masayuki 原正之

[Journal Article] Analysis of ZIP (Zrt-, Irt-related protein) transporter gene expression in murine neural　stem/progenitor cells2017

[Journal Article] Migration of glial cells differentiated from neurosphere-forming　neural stem/progenitor cells depends on the　stiffness of the chemically cross-linked collagen gel substrate2013