USUI Shinichi 臼井真一

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USUI SHINICHI 臼井真一

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Researcher Number	50346417
Other IDs
Affiliation (Current)	2023: 鳥取大学, 医学部, 教授
Affiliation (based on the past Project Information) *help	2020 – 2022: 鳥取大学, 医学部, 教授 2015 – 2019: 岡山大学, 保健学研究科, 准教授 2008 – 2011: Okayama University, 大学院・保健学研究科, 准教授 2007: Okayama University, 大学院・保健学研究科, 助教 2004 – 2006: 岡山大学, 医学部, 助手
Review Section/Research Field	Principal Investigator Laboratory medicine / Applied health science / Basic Section 38050:Food sciences-related / Basic Section 59040:Nutrition science and health science-related Except Principal Investigator Laboratory medicine / Psychiatric science / Surgery related to the biological and sensory functions and related fields / Basic Section 59040:Nutrition science and health science-related / Basic Section 38050:Food sciences-related
Keywords	Principal Investigator HDL / 動脈硬化 / リポタンパク質 / アポリポプロテインE / 臨床化学 / トリグリセリド / 肥満 / 危険因子 / ニトロチロシン / 酸化ストレス … More / アポリポタンパク質 / ELISA / 臨床検査 / 生化学検査 / 脂質検査 / 脂質 / アポリポ蛋白E / 生活習慣病モデルマウス / リポ蛋白 / 細胞培養 / 脂肪細胞 / アポリポ蛋白Ｅ / ＨＤＬ / エタノール / HDL受容体 / コレステロール / リポ蛋白代謝 / HepG2 / アルコール / メタボリックシンドローム / 脂肪肝 / アポE / 生活習慣病 … More Except Principal Investigator HDL / コレステロール / 非アルコール性脂肪肝炎 / 生活習慣病 / 循環器・高血圧 / 虚血 / 細胞・組織 / 内皮細胞 / 興奮性神経細胞死 / マウス / カイニン酸 / 海馬 / 錐体細胞 / Fc受容体欠損マウス / ミクログリア / アストロサイト / Fc受容体 / 遺伝子欠損 / 局所注入 / 錐体細胞死 / excitotoxic neuronal death / mouse / kainic acid / hippocampus / pyramidal cell loss / FcR-deficient mouse / microglia / astrocyte / 遺伝子 / 非アルコール脂肪肝炎 / 中性脂肪 / リポ蛋白 / NAFL / NASH Less

コレステロールと脂肪摂取の相乗作用による非アルコール性脂肪肝疾患の発症メカニズム
- Principal Investigator
  
  篠畑綾子
- Project Period (FY)
  2021 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 38050:Food sciences-related
- Research Institution
  Okayama University
メタボリックシンドロームの発症・進展におけるアポE含有HDLの関与の可能性Principal Investigator
- Principal Investigator
  
  臼井真一
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 59040:Nutrition science and health science-related
- Research Institution
  Tottori University
Establishment of molecular mechanism for moderate alcohol intake to prevent atherosclerosisPrincipal Investigator
- Principal Investigator
  
  USUI Shinichi
- Project Period (FY)
  2018 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 38050:Food sciences-related
- Research Institution
  Tottori University
  Okayama University
Prevention strategy for non-alcoholic steatohepatitis based on hepatic cholesterol efflux by HDL
- Principal Investigator
  
  Shinohata Ryoko
- Project Period (FY)
  2018 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 59040:Nutrition science and health science-related
- Research Institution
  Okayama University
Challenge for liquid biopsy of osteoarthritis
- Principal Investigator
  
  HIROHATA SATOSHI
- Project Period (FY)
  2017 – 2018
- Research Category
  
  Grant-in-Aid for Challenging Research (Exploratory)
- Research Field
  
  Surgery related to the biological and sensory functions and related fields
- Research Institution
  Okayama University
The role of apoE-rich HDL in lifestyle diseasesPrincipal Investigator
- Principal Investigator
  
  USUI SHINICHI
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Applied health science
- Research Institution
  Okayama University
Development of a clinically useful method for measuring serum triglyceridesPrincipal Investigator
- Principal Investigator
  
  USUI Shinichi
- Project Period (FY)
  2010 – 2011
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Laboratory medicine
- Research Institution
  Okayama University
Development of a new and useful method in clinical testing of HDL subfractionsPrincipal Investigator
- Principal Investigator
  
  USUI Shinichi
- Project Period (FY)
  2008 – 2009
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Laboratory medicine
- Research Institution
  Okayama University
内皮細胞由来ADAMTS1の虚血バイオマーカーとしての可能性
- Principal Investigator
  
  HIROHATA SATOSHI
- Project Period (FY)
  2007 – 2008
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  Laboratory medicine
- Research Institution
  Okayama University
動脈硬化症における血中ニトロチロシン含有リポタンパク質測定の臨床的意義Principal Investigator
- Principal Investigator
  
  臼井真一
- Project Period (FY)
  2006 – 2007
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Laboratory medicine
- Research Institution
  Okayama University
ヒト血中アポE含有HDLの定量分析法の確立と臨床応用Principal Investigator
- Principal Investigator
  
  臼井真一
- Project Period (FY)
  2004 – 2005
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Laboratory medicine
- Research Institution
  Okayama University
The role of Fc receptors in microglial activation and excototoxic neuronal death.
- Principal Investigator
  
  OKAMOTO Motoi
- Project Period (FY)
  2004 – 2005
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Psychiatric science
- Research Institution
  Okayama University

All 2022 2020 2019 2018 2017 2016 2015 2008

All Journal Article Presentation Patent

[Journal Article] A high-fat/high-cholesterol diet, but not high-cholesterol alone, increases free cholesterol and apoE-rich HDL serum levels in rats and upregulates hepatic ABCA1 expression.2022
- Author(s)
  Shinohata Ryoko, Shibakura Misako, Arao Yujiro, Watanabe Shogo, Hirohata Satoshi, Usui Shinichi
- Journal Title
  
  Biochimie
  
  Volume: 197 Pages: 49-58
- DOI
  10.1016/j.biochi.2022.01.011
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K05470, KAKENHI-PROJECT-18K05488, KAKENHI-PROJECT-18K11073, KAKENHI-PROJECT-20H00548, KAKENHI-PROJECT-21K11622
[Journal Article] Low plasma apolipoprotein E-rich high-density lipoprotein levels in patients with metabolic syndrome2020
- Author(s)
  Shinohata Ryoko、Shiga Yuhei、Miura Shin-ichiro、Hirohata Satoshi、Shibakura Misako、Ueno-Iio Tomoe、Watanabe Shogo、Arao Yujiro、Usui Shinichi
- Journal Title
  
  Clinica Chimica Acta
  
  Volume: 510 Pages: 531-536
- DOI
  10.1016/j.cca.2020.08.020
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K05488, KAKENHI-PROJECT-18K11073, KAKENHI-PROJECT-19K11767, KAKENHI-PROJECT-20H00548
[Journal Article] Bile acid metabolism is an intermediary factor between non-alcoholic steatohepatitis and ischemic heart disease in SHRSP5/Dmcr rats2019
- Author(s)
  Kumazaki Shota、Nakamura Mayu、Sasaki Shun、Tagashira Rina、Maruyama Nozomi、Sato Ikumi、Yamamoto Shusei、Ran Shang、Usui Shinichi、Shinohata Ryoko、Ohtsuki Takashi、Hirohata Satoshi、Kitamori Kazuya、Mori Mari、Yamori Yukio、Watanabe Shogo
- Journal Title
  
  Journal of Nutrition and Food Sciences
  
  Volume: 09 Pages: 763-763
- DOI
  10.35248/2155-9600.19.9.763
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K05488, KAKENHI-PROJECT-18K11073, KAKENHI-PROJECT-19K09627, KAKENHI-PROJECT-17H04313
[Journal Article] A High-Fat and High-Cholesterol Diet Induces Cardiac Fibrosis, Vascular Endothelial, and Left Ventricular Diastolic Dysfunction in SHRSP5/Dmcr Rats2018
- Author(s)
  Watanabe S, Kumazaki S, Kusunoki K, Inoue T, Maeda Y, Usui S, Shinohata R, Ohtsuki T, Hirohata S, Kusachi S, Kitamori K, Mori M, Yamori Y, Oka H.
- Journal Title
  
  J Atheroscler Thromb
  
  Volume: 印刷中 Issue: 5 Pages: 439-453
- DOI
  10.5551/jat.40956
- NAID
  130006729837
- ISSN
  1340-3478, 1880-3873
- Language
  English
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K19727, KAKENHI-PROJECT-17H04313, KAKENHI-PROJECT-15K01715, KAKENHI-PROJECT-16K10905
[Journal Article] A rapid and precise method for measuring plasma apoE-rich HDL using polyethylene glycol and cation-exchange chromatography: a pilot study on the clinical significance of apoE-rich HDL measurements.2017
- Author(s)
  Ikeda T, Shinohata R, Murakami M, Hina K, Kamikawa S, Hirohata S, Kusachi S, Tamura A, Usui S.
- Journal Title
  
  Clin Chim Acta.
  
  Volume: 465 Pages: 112-118
- DOI
  10.1016/j.cca.2016.12.016
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-26293338, KAKENHI-PROJECT-15K01715
[Journal Article] Lavender Essential Oil and Its Main Constituents Inhibit the Expression of TNF-α-induced Cell Adhesion Molecules in Endothelial Cells2017
- Author(s)
  Michinori Aoe, Tomoe Ueno-Iio, Misako Shibakura, Ryoko Shinohata, Shinichi Usui, Yujiro Arao, Satoru Ikeda, Nobuaki Miyahara,　Mitsune Tanimoto, and Mikio Kataoka
- Journal Title
  
  Acta Medica Okayama
  
  Volume: 71 Issue: 6 Pages: 493-503
- DOI
  10.18926/AMO/55586
- NAID
  120006370713
- URL
  https://ousar.lib.okayama-u.ac.jp/55586
- Language
  English
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K17900, KAKENHI-PROJECT-15K01715
[Patent] アポＥ含有ＨＤＬの測定方法および測定装置2015
- Inventor(s)
  臼井真一，草地省蔵，臼井綾子
- Industrial Property Rights Holder
  岡山大学
- Industrial Property Rights Type
  特許
- Filing Date
  2015-08-10
- Data Source
  KAKENHI-PROJECT-15K01715
[Patent] 急性虚血性疾患の診断薬2008
- Inventor(s)
  廣畑聡, 臼井真一, 草地省蔵
- Industrial Property Rights Holder
  岡山大学
- Acquisition Date
  2008-10-03
- Data Source
  KAKENHI-PROJECT-19659142
[Presentation] Circulating platelet-activating factor acetylhydrolase activity increases in rats with non-alcoholic steatohepatitis with fibrosis induced by high-fat/high-cholesterol diet2022
- Author(s)
  Usui S, Shinohata R, Arao Y
- Organizer
  2022 AACC Annual Scientific Meeting & Clinical Lab Expo
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K05470
[Presentation] Analysis of Serum HDL Subclass in Mouse Obesity Models by Cation-Exchange Chromatography.2019
- Author(s)
  Shinohata R, Shibakura M, Ueno-Iio T, Arao U, Watanabe S, Hirohata S, Okazaki M, Usui S.
- Organizer
  71st AACC Annual Scientific Meeting & Clinical Lab Expo.
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K11073
[Presentation] Analysis of Serum HDL Subclass in Mouse Obesity Models by Cation-Exchange Chromatography2019
- Author(s)
  Shinohata R, Shibakura M, Ueno-Iio T, Arao Y, Watanabe S, Hirohata S, Okazaki M, Usui S
- Organizer
  71st AACC Annual Scientific Meeting & Clinical Lab Expo
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K05488
[Presentation] Analysis of serum HDL subclass from rats with non-alcoholic fatty liver disease induced by high-fat and high-cholesterol diet.2018
- Author(s)
  Shinohata R, Watanabe S, Hirohata S, Nakajima K, Okazaki M, Usui S.
- Organizer
  第70回米国臨床化学会学術集会(AACC 70th Annual Scientific Meeting)
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K19727
[Presentation] Analysis of serum HDL subclass from rats with non-alcoholic fatty liver disease induced by high-fat and high-cholesterol diet2018
- Author(s)
  Shinohata R, Watanabe S, Hirohata S, Nakajima K, Okazaki M, Usui S
- Organizer
  70th AACC Annual Scientific Meeting & Clinical Lab Expo
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K05488
[Presentation] Analysis of serum HDL subclass from rats with non-alcoholic fatty liver disease induced by high-fat and high-cholesterol diet2018
- Author(s)
  Shinohata R, Watanabe S, Hirohata S, Nakajima K, Okazaki M, Usui S.
- Organizer
  70th AACC Annual Scientific Meeting and Clinical Lab Expo
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K11073
[Presentation] ApoE-rich HDL in pre-heparin plasma may be HDL remnants which remain in the circulation2017
- Author(s)
  Usui S, Shinohata R, Miyashita K, Hirohata S, Shibakura S, Fukamachi I, Nakajima K
- Organizer
  69th AACC Annual Scientific Meeting & Clinical Lab Expo
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K01715
[Presentation] ApoE-rich HDL in pre-heparin plasma may be HDL remnants which remain in the circulation.2017
- Author(s)
  Usui S, Shinohata R, Miyashita K, Hirohata S, Shibakura M, Fukamachi I, Nakajima K.
- Organizer
  67th AACC annual scientifi meeting & clinical lab expo.
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K19727
[Presentation] LDL particle size associates with apoE-containing HDL in patients who undergo coronary computed tomographic angiography.2016
- Author(s)
  Shinohata R, Ikeda T, Murakami M, Hina K, Kamikawa S, Hirohata S, Kusachi S, Nakajima K, Ikeda S, Usui S.
- Organizer
  68th AACC Annual Scientific Meeting & Clinical Lab Expo
- Place of Presentation
  Philadelphia(America)
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K01715
[Presentation] Hepatic triglyceride lipase is mainly located on apoE-rich HDＬ in post-heparin plasma2015
- Author(s)
  Usui S, Shinohata R, Nakajima K, Miyashita K, Imamura S, Sato K, Okajima F, Kobayashi J, Shirakawa T, Shimomura Y, Machida T, Sumino H, Murakami M
- Organizer
  2015 American Association for Clinical Chemistry Annual Meeting
- Place of Presentation
  Ａｔｌａｎｔａ（Ａｍｅｒｉｃａ）
- Year and Date
  2015-07-29
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K01715

1. SHINOHATA Ryoko (70335587)

# of Collaborated Projects: 5 results

# of Collaborated Products: 14 results
2. HIROHATA SATOSHI (90332791)

# of Collaborated Projects: 4 results

# of Collaborated Products: 11 results
3. 柴倉美砂子 (30314694)

# of Collaborated Projects: 2 results

# of Collaborated Products: 3 results
4. OKAMOTO Motoi (80144757)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
5. ISHIKAWA Tetsuya (90221754)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. SATO Hiaki (70362960)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. 三好亨 (70444651)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. 草地省蔵 (30214943)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. 大月孝志 (10534802)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
10. 稲垣純子 (90271056)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. 下廣寿 (90583758)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
12. WATANABE Shogo

# of Collaborated Projects: 0 results

# of Collaborated Products: 4 results

USUI Shinichi 臼井 真一

USUI SHINICHI 臼井 真一

Research Projects

Research Products

Co-Researchers

コレステロールと脂肪摂取の相乗作用による非アルコール性脂肪肝疾患の発症メカニズム

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

メタボリックシンドロームの発症・進展におけるアポE含有HDLの関与の可能性Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Establishment of molecular mechanism for moderate alcohol intake to prevent atherosclerosisPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Prevention strategy for non-alcoholic steatohepatitis based on hepatic cholesterol efflux by HDL

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Challenge for liquid biopsy of osteoarthritis

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

The role of apoE-rich HDL in lifestyle diseasesPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Development of a clinically useful method for measuring serum triglyceridesPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Development of a new and useful method in clinical testing of HDL subfractionsPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

内皮細胞由来ADAMTS1の虚血バイオマーカーとしての可能性

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

動脈硬化症における血中ニトロチロシン含有リポタンパク質測定の臨床的意義Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

ヒト血中アポE含有HDLの定量分析法の確立と臨床応用Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

The role of Fc receptors in microglial activation and excototoxic neuronal death.

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] A high-fat/high-cholesterol diet, but not high-cholesterol alone, increases free cholesterol and apoE-rich HDL serum levels in rats and upregulates hepatic ABCA1 expression.2022

Author(s)

Journal Title

USUI Shinichi 臼井真一

USUI SHINICHI 臼井真一