HISATSUNE AKINORI 久恒昭哲

… Alternative Names

Researcher Number	50347001
Other IDs
Affiliation (Current)	2022: 熊本大学, 薬学部, 非常勤講師
Affiliation (based on the past Project Information) *help	2019: 熊本大学, 薬学部, 非常勤講師 2018: 熊本大学, 大学院先導機構, 特定事業教員 2013: 熊本大学, 大学院先導機構, 特任准教授 2013: 熊本大学, 生命科学研究部, 准教授 2011 – 2013: 熊本大学, 大学院生命科学研究部, 助教 … More
Review Section/Research Field	Principal Investigator Biological pharmacy / Basic Section 59040:Nutrition science and health science-related Except Principal Investigator Biological pharmacy / General internal medicine (including Psychosomatic medicine) / General pharmacology
Keywords	Principal Investigator シアル酸 / Toll-like受容体5 / フラジェリン / MUC1 / 自然免疫 / Toll様受容体 / ムチン / 神経細胞 / ミクログリア / 中枢神経系 … More Except Principal Investigator アクアポリン / 肺胞上皮細胞 / ミクログリア / Sp3転写因子 / ガス交換 / 一酸化窒素 / 東洋医学 / 未病 / 抗MUC1抗体 / 抗腫瘍 / グリチルリチン / インターフェロン-γ / 診断マーカー / MUC1 / 脳卒中 / トロンビン / ニコチン / レチノイド / ヘムオキシゲナーゼ / アポトーシス / 神経保護 / 好中球 / 線条体 / 腫瘍壞死因子 / 脳内出血 / 神経細胞死 / ポリアミン / 大脳皮質 / 転写因子Sp3 / 肺上皮細胞 / 転写因子 / 細胞分化 / アクアポリ / 肺気腫 / 肺胞II型上皮細胞 / Sp3 / 分化 / 炎症 / サイトカイン / 桂皮 / インターロイキン-4 / アルギナーゼ / GABA / 透過性 / Sp1転写因子 / 細胞内局在 / レチノイン酸 / Aquaporin-5 / p38 MAP kinase / CO_2ガス / Gas exchange / Aquaporin / Membrane permeability / Sp1 transcription factor / Subcellular distribution / DNAメチル化 / CO_2がス透過性 / alveolar epithelial cell / gas exchange / aquaporin / nitric oxide / DNA methylation Less

精神症状の発現に関わるガングリオシドの作用Principal Investigator
- Principal Investigator
  
  久恒昭哲
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 59040:Nutrition science and health science-related
- Research Institution
  Kumamoto University
Low molecular weight compounds that direct microglia toward alternative activation
- Principal Investigator
  
  KATSUKI Hiroshi
- Project Period (FY)
  2012 – 2013
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  General pharmacology
- Research Institution
  Kumamoto University
Pathophysiological significance of sialic acid in CNSPrincipal Investigator
- Principal Investigator
  
  HISATSUNE Akinori
- Project Period (FY)
  2011 – 2013
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Biological pharmacy
- Research Institution
  Kumamoto University
A new function of aquaporin provide a insight into the molecular mechanism to inhibit inflammatory response
- Principal Investigator
  
  ISOHAMA Yoichiro
- Project Period (FY)
  2011 – 2013
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Biological pharmacy
- Research Institution
  Tokyo University of Science
  Kumamoto University
Research on pathology and protection of intracerebral hemorrhage with special reference to microglial functions
- Principal Investigator
  
  KATSUKI Hiroshi
- Project Period (FY)
  2008 – 2010
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Biological pharmacy
- Research Institution
  Kumamoto University
Sp3 and its regulatory effect of gene expression provide new insights to treat chronic obstructive pulmonary disease.
- Principal Investigator
  
  ISOHAMA Yoichiro
- Project Period (FY)
  2008 – 2010
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Biological pharmacy
- Research Institution
  Kumamoto University
Pharmacological study to cure mibyo, disease-oriented state
- Principal Investigator
  
  MIYATA Takeshi
- Project Period (FY)
  2007 – 2009
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  General internal medicine (including Psychosomatic medicine)
- Research Institution
  Sojo University
Significance of increase in aquaporin 5 expression in respiratory system
- Principal Investigator
  
  ISOHAMA Yoichiro
- Project Period (FY)
  2006 – 2007
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Biological pharmacy
- Research Institution
  Kumamoto University
Toll-like受容体-5シグナル伝達に対する膜結合型ムチンMUCIの調節作用Principal Investigator
- Principal Investigator
  
  久恒昭哲
- Project Period (FY)
  2004 – 2005
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Biological pharmacy
- Research Institution
  Kumamoto University
CO_2 gas transporter in plasma membrane which is involved in gas exchange
- Principal Investigator
  
  ISOHAMA Yoichiro
- Project Period (FY)
  2004 – 2005
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Biological pharmacy
- Research Institution
  Kumamoto University

All 2014 2013 2012 2011 2010 2009 2008 2007 2006 2005 Other

All Journal Article Presentation Patent

[Journal Article] Suppression of CXCL2 upregulation underlies the therapeutic effect of the retinoid Am80 on intracerebral hemorrhage in mice.2014
- Author(s)
  Matsushita H, Hijioka M, Ishibashi H, Anan J, Kurauchi Y, Hisatsune A, Seki T, Shudo K, Katsuki H.
- Journal Title
  
  J Neurosci Res.
  
  Volume: in press
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23590108
[Journal Article] Aquaporin 5 increases keratinocyte-derived chemokine expression and NF-κB activity through ERK activation.2014
- Author(s)
  Sakamoto Y, Hisatsune A, Katsuki H, Horie I, Isohama Y
- Journal Title
  
  Biochemical and Biophysical Research Commununications
  
  Volume: 448 Pages: 355-360
- DOI
  10.1016/j.bbrc.2014.04.047
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-23590109, KAKENHI-PROJECT-26460078, KAKENHI-PROJECT-26670036
[Journal Article] Suppression of CXCL2 upregulation underlies the therapeutic effect of the retinoid Am80 on intracerebral hemorrhage in mice2014
- Author(s)
  Matsushita H, Hijioka M, Ishibashi H, Anan J, Kurauchi Y, Hisatsune A, Seki T, Shudo K, Katsuki H
- Journal Title
  
  J Neurosci Res
  
  Volume: (Epub ahead of print)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23590108
[Journal Article] Nitric oxide mediates selective degeneration of hypothalamic orexin neurons through dysfunction of protein disulfide isomerase2013
- Author(s)
  Obukuro K, Nobunaga M, Takigawa M, Morioka H, Hisatsune A, Isohama Y, Shimokawa H, Tsutsui M, Katsuki H.
- Journal Title
  
  J. Neurosci.
  
  Volume: 33(31) Pages: 12557-12568
- DOI
  10.1523/jneurosci.0595-13.2013
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23590108, KAKENHI-PROJECT-23590305, KAKENHI-PROJECT-24659118
[Journal Article] MRI-based analysis of intracerebral hemorrhage in mice reveals relationship between hematoma expansion and the severity of symptoms2013
- Author(s)
  Matsushita H, Hijioka M, Hisatsune A, Isohama Y, Iwamoto S, Terasawa H, Katsuki H
- Journal Title
  
  PLoS One
  
  Volume: 8(7)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23590108
[Journal Article] Nitric oxide/soluble guanylyl cyclase signaling mediates depolarization-induced protection of rat mesencephalic dopaminergic neurons from MPP cytotoxicity2013
- Author(s)
  Kurauchi Y, Hisatsune A, Isohama Y, Sawa T, Akaike T, Katsuki H
- Journal Title
  
  Neuroscience
  
  Volume: 231 Pages: 206-15
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23590108
[Journal Article] Nitric oxide mediates selective degeneration of hypothalamic orexin neurons through dysfunction of protein disulfide isomerase2013
- Author(s)
  Obukuro K, Nobunaga M, Takigawa M, Morioka H, Hisatsune A, Isohama Y, Shimokawa H, Tsutsui M, Katsuki H
- Journal Title
  
  J Neurosci
  
  Volume: 33 Pages: 12557-12568
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23590109
[Journal Article] Natural and synthetic retinoids afford therapeutic effects on intracerebral hemorrhage in mice2013
- Author(s)
  Matsushita H, Hijioka M, Hisatsune A, Isohama Y, Shudo K, Katsuki H.
- Journal Title
  
  Eur J Pharmacol
  
  Volume: 683(1-3) Pages: 125-131
- DOI
  10.1016/j.ejphar.2012.03.023
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23590108, KAKENHI-PROJECT-23590109, KAKENHI-PROJECT-24659118, KAKENHI-PUBLICLY-23117714
[Journal Article] Nitric oxide mediates selective degeneration of hypothalamic orexin neurons through dysfunction of protein disulfide isomerase2013
- Author(s)
  Obukuro K, Nobunaga M, Takigawa M, Morioka H, Hisatsune A, Isohama Y, Shimokawa H, Tsutsui M, Katsuki H
- Journal Title
  
  J Neurosci
  
  Volume: 33(31) Pages: 12557-68
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23590108
[Journal Article] MRI-based analysis of intracerebral hemorrhage in mice reveals relationship between hematoma expansion and the severity of symptoms.2013
- Author(s)
  松下英明
- Journal Title
  
  PLoS One.
  
  Volume: e67691
- DOI
  10.1371/journal.pone.0067691
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-12J08698, KAKENHI-PROJECT-23590108, KAKENHI-PROJECT-23590109, KAKENHI-PROJECT-24659118
[Journal Article] Nitric oxide/soluble guanylyl cyclase signaling mediates depolarization-induced protection of rat mesencephalic dopaminergic neurons from MPP+ cytotoxicity.2013
- Author(s)
  Kurauchi Y, Hisatsune A, Isohama Y, Sawa T, Akaike T and Katsuki H.
- Journal Title
  
  Neuroscience.
  
  Volume: 231 Pages: 206-215
- DOI
  10.1016/j.neuroscience.2012.11.044
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-11F01105, KAKENHI-ORGANIZER-20117001, KAKENHI-PLANNED-20117005, KAKENHI-PROJECT-23590108, KAKENHI-PROJECT-23590109, KAKENHI-PROJECT-23651239, KAKENHI-PROJECT-24390082, KAKENHI-PROJECT-24659118, KAKENHI-PROJECT-24890225, KAKENHI-PROJECT-25220103, KAKENHI-PUBLICLY-23117714
[Journal Article] α7 Nicotinic acetylcholine receptor agonist attenuates neuropathological changes associated with intracerebral hemorrhage in mice2012
- Author(s)
  Hijioka M, Matsushita H, Ishibashi H, Hisatsune A, Isohama Y, Katsuki H.
- Journal Title
  
  Neuroscience
  
  Volume: 222 Pages: 10-19
- DOI
  10.1016/j.neuroscience.2012.07.024
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23590108, KAKENHI-PROJECT-23590109, KAKENHI-PROJECT-24659118, KAKENHI-PUBLICLY-23117714
[Journal Article] Natural and synthetic retinoids afford therapeutic effects on intracerebral hemorrhage in mice2012
- Author(s)
  Matsushita H, Hijioka M, Hisatsune A, Isohama Y, Shudo K, Katsuki H
- Journal Title
  
  Eur J Pharmacol
  
  Volume: 683(1-3) Pages: 125-31
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23590108
[Journal Article] Natural and synthetic retinoids afford therapeutic effects on intracerebral hemorrhage in mice.2012
- Author(s)
  Matsushita H, Hijioka M, Hisatsune A, Isohama Y, Shudo K, Katsuki H.
- Journal Title
  
  Eur J Pharmacol. Mar 23.
  
  Volume: .
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23590108
[Journal Article] Caffeic acid phenethyl ester protects nigral dopaminergic neurons via dual mechanisms involving haem oxygenase-1 and brain-derived neurotrophic factor2012
- Author(s)
  Kurauchi Y, Hisatsune A, Isohama Y, Mishima S, Katsuki H
- Journal Title
  
  Br J Pharmacol
  
  Volume: 166(3) Pages: 1151-68
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23590108
[Journal Article] Caffeic acid phenethyl ester protects nigral dopaminergic neurons via dual mechanisms involving haem oxygenase-1 and brain-derived neurotrophic factor.2012
- Author(s)
  倉内祐樹
- Journal Title
  
  Br J Pharmacol.
  
  Volume: (in press) Pages: 1151-1168
- DOI
  10.1111/j.1476-5381.2012.01833.x
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-10J07329, KAKENHI-PUBLICLY-23117714, KAKENHI-PROJECT-23590108, KAKENHI-PROJECT-23590109, KAKENHI-PROJECT-24659118
[Journal Article] α7 Nicotinic acetylcholine receptor agonist attenuates neuropathological changes associated with intracerebral hemorrhage in mice2012
- Author(s)
  Hijioka M, Matsushita H, Ishibashi H, Hisatsune A, Isohama Y, Katsuki H
- Journal Title
  
  Neuroscience
  
  Volume: 222 Pages: 10-9
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23590108
[Journal Article] Orexin neurons in hypothalamic slice cultures are vulnerable to endoplasmic reticulum stress2011
- Author(s)
  Michinaga S(第一著者)
- Journal Title
  
  Neuroscience
  
  Volume: 190 Pages: 289-300
- DOI
  10.1016/j.neuroscience.2011.06.026
- Peer Reviewed
- Data Source
  KAKENHI-PUBLICLY-23117714, KAKENHI-PROJECT-23590109
[Journal Article] Anti-MUC1 antibody inhibits EGF receptor signaling in cancer cells.2011
- Author(s)
  Hisatsune A, Nakayama H, Kawasaki M, Horie I, Miyata T, Isohama Y, Kim KC, Katsuki H
- Journal Title
  
  Biochem Biophys Res Commun 405
  
  Pages: 377-381
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590084
[Journal Article] Therapeutic effect of nicotine in a mouse model of intracerebral hemorrhage2011
- Author(s)
  Hijioka M, Matsushita H, Hisatsune A, Isohama Y, Katsuki H
- Journal Title
  
  J Pharmacol Exp Ther
  
  Volume: 338(3) Pages: 741-9
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23590108
[Journal Article] Orexin neurons in hypothalamic slice cultures are vulnerable to endoplasmic reticulum stress2011
- Author(s)
  Michinaga S, Hisatsune A, Isohama Y, Katsuki H
- Journal Title
  
  Neuroscience
  
  Volume: 190 Pages: 289-300
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23590108
[Journal Article] Therapeutic effect of nicotine in a mouse model of intracerebral hemorrhage.2011
- Author(s)
  Hijioka M, Matsushita H, Hisatsune A, Isohama Y, Katsuki H.
- Journal Title
  
  J Pharmacol Exp Ther.
  
  Volume: 338(3) Pages: 741-749
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23590108
[Journal Article] Anti MUC1 antibody inhibits EGF receptor signaling in cancer cells.2011
- Author(s)
  Hisatsune A(第一著者)
- Journal Title
  
  Biochem Biophys Res Commun.
  
  Volume: 405 Pages: 377-381
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20390026
[Journal Article] A retinoicacid receptor agonist Am80 rescues neurons, attenuates inflammatory reactions, and improves behavioral recovery after intracerebral hemorrhage in mice.2011
- Author(s)
  Matsushita H, Hijioka M, Hisatsune A, Isohama Y, Shudo K, Katsuki H.
- Journal Title
  
  J Cereb Blood Flow Metab. 31(1)
  
  Pages: 222-234
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20390026
[Journal Article] Orexin neurons in hypothalamic slice cultures are vulnerable to endoplasmic reticulum stress.2011
- Author(s)
  Michinaga S, Hisatsune A, Isohama Y, Katsuki H.
- Journal Title
  
  Neuroscience
  
  Volume: 190 Pages: 289-300
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23590108
[Journal Article] Anti-MUC1 antibody inhibits EGF receptor signaling in cancer cells.2011
- Author(s)
  Hisatsune A, ほか
- Journal Title
  
  Biochem Biophys Res Commun
  
  Volume: 405 Pages: 377-381
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590084
[Journal Article] Anti-MUC1 antibody inhibits EGF receptor signaling in cancer cells2011
- Author(s)
  Hisatsune A
- Journal Title
  
  Biochem Biophys Res Commun
  
  Volume: VOL.405 Pages: 377-381
- DOI
  10.1016/j.bbrc.2011.01.029
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590672, KAKENHI-PROJECT-23590109
[Journal Article] Therapeutic effect of nicotine in a mouse model of intracerebral hemorrhage2011
- Author(s)
  Hijioka M(第一著者)
- Journal Title
  
  J Pharmacol Exp Ther
  
  Volume: 338 Pages: 741-749
- DOI
  10.1124/jpet.111.182519
- Peer Reviewed
- Data Source
  KAKENHI-PUBLICLY-23117714, KAKENHI-PROJECT-23590109
[Journal Article] A retinoic acid receptor agonist Am80 rescues neurons, attenuates inflammatory reactions, and improves behavioral recovery after intracerebral hemorrhage in mice.2011
- Author(s)
  Matsushita H, Hijioka M, Hisatsune A, Isohama Y, Shudo K, Katsuki H.
- Journal Title
  
  J Cereb Blood Flow Metab 31
  
  Pages: 222-234
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590084
[Journal Article] Anti-MUC1 antibody inhibits EGF receptor signaling in cancer cells.2011
- Author(s)
  Hisatsune Aほか
- Journal Title
  
  Biochem Biophys Res Commun.
  
  Volume: 405 Pages: 377-381
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23590109
[Journal Article] Glycyrrhizin attenuates mucus production by inhibition of MUC5AC mRNA expression in vivo and in vitro.2010
- Author(s)
  Nishimoto Y, Hisatsune A, Katsuki H, Miyata T, Yokomizo K, Isohama Y.
- Journal Title
  
  J Pharmacol Sci. 113
  
  Pages: 76-83
- NAID
  10027745175
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590084
[Journal Article] Tumor necrosis factor-αdecreases aquaporin-3 expression in DJM-1 keratinocytes.2009
- Author(s)
  Horie I, Maeda M, Yokoyama S, Hisatsune A, Katsuki H, Miyata T, Isohama Y.
- Journal Title
  
  Biochem Biophys Res Commun. 387
  
  Pages: 564-568
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19390193
[Journal Article] Internalization of MUC1 by anti-MUC1 antibody from cell membrane through the macropinocytotic pathway2009
- Author(s)
  Hisatsune A(第一著者)
- Journal Title
  
  Biochem Biophys Res Commun 388
  
  Pages: 677-682
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20390026
[Journal Article] Tumor necrosis factor-alpha decreases aquaporin-3 expression in DJM-1 keratinocytes.2009
- Author(s)
  Horie I, Maeda M, Yokoyama S, Hisatsune A, Katsuki H, Miyata T, Isohama Y.
- Journal Title
  
  Biochem Biophys Res Commun. 387
  
  Pages: 564-568
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590084
[Journal Article] Bacterial neuraminidase increases IL-8 production in lung epithelial cells via NF-kappaB-dependent pathway.2009
- Author(s)
  Kuroiwa A, Hisatsune A, Isohama Y, Katsuki H.
- Journal Title
  
  Biochem Biophys Res Commun. 379
  
  Pages: 754-759
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590084
[Journal Article] Hypoxia enhances MUC1 expression in a lung adenocarcinoma cell line.2009
- Author(s)
  Mikami Y, Hisatsune A, Tashiro T, Isohama Y, Katsuki H.
- Journal Title
  
  Biochem Biophys Res Commun. 379
  
  Pages: 1060-1065
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590084
[Journal Article] Internalization of MUC1 by anti-MUC1 antibody from cell membrane through the macropinocytotic pathway.2009
- Author(s)
  Hisatsune A, Kawasaki M, Nakayama H, Mikami Y, Miyata T, Isohama Y, Katsuki H, Kim KC.
- Journal Title
  
  Biochem Biophys Res Commun. 388
  
  Pages: 677-682
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590084
[Journal Article] Involvement of DNA-methylation in AQP5 gene expression in alveolar epithelial cells.(in Japanese)2008
- Author(s)
  Isohama, Y., Nomura, J., Harada, S., Hisatsune, A., Katsuki, H., Miyata, T.
- Journal Title
  
  Respr Mol Med 12
  
  Pages: 52-56
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18590061
[Journal Article] Glycyrrhizin inhibits interleukin-8 production and nuclear factor-kappaB activity in lung epithelial cells, but not through glucocorticoid receptors.2008
- Author(s)
  Takei H, Baba Y, Hisatsune A, Katsuki H, Miyata T, Yokomizo K, Isohama Y.
- Journal Title
  
  J Pharmacol Sci 106
  
  Pages: 460-468
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19390193
[Journal Article] Glycyrrhizin inhibits interleukin-8 production and NF-κB activity in lung epithelial cells, but not through glucocorticoid receptors2008
- Author(s)
  Takei, H., Baba, Y., Hisatsune, A., Katsuki, H., Miyata, T., Yokomizo, K., Isohama, Y.
- Journal Title
  
  J Phamrmacol Sci 293
  
  Pages: 460-468
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18590061
[Journal Article] Nitric oxide decreases cell surface expression of aquaporin-5 and membrane water permeability in lung epithelial cells.2007
- Author(s)
  Nagai K., Watanabe M., Seto M., Hisatsune A., Miyata T., Isohama Y
- Journal Title
  
  Biochem Biophys Res Commun 354
  
  Pages: 579-584
- Data Source
  KAKENHI-PROJECT-18590061
[Journal Article] The role of CpG methylation in cell type-specific expression of the aquaporin-5 gene2007
- Author(s)
  Nomura, J., Hisatsune, A., Miyata, T., Isohama, Y.
- Journal Title
  
  Biochem Biophys Res Commun 353
  
  Pages: 1017-1022
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18590061
[Journal Article] Nitric oxide decreases cell surface expression of aquaporin-5 and membrane water permeability in lung epithelial cells2007
- Author(s)
  Nagai, K., Watanabe, M., Seto, M., Hisatsune, A., Miyata, T., Isohama, Y.
- Journal Title
  
  Biochem Biophys Res Commun 354
  
  Pages: 579-584
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18590061
[Journal Article] The role of CpG methylation in cell type-specific expression of the aquaporin-52007
- Author(s)
  Nomura J., Hisatsune A., Miyata T., Isohama Y
- Journal Title
  
  Biochem Biophys Res Commun 353
  
  Pages: 1017-1022
- Data Source
  KAKENHI-PROJECT-18590061
[Journal Article] All-trans retinoic acid increases expression of aquaporin-5 and plasma membrane water permeability via transactivation of Sp1 in mouse lung epithelial cells.2006
- Author(s)
  Nomura J., Horie I., Seto M., Nagai K., Hisatsune A., Miyata T., Isohama Y
- Journal Title
  
  Biochem Biophys Res Commun 351
  
  Pages: 1048-1053
- Data Source
  KAKENHI-PROJECT-18590061
[Journal Article] All-trans retinoic acid increases expression of aquaporin-5 and plasma membrane water permeability via transactivation of Sp1 in mouse lung epithelial cells2006
- Author(s)
  Nomura, J., Horie, I., Seto, M., Nagai, K., Hisatsune, A., Miyata, T., Isohama, Y.
- Journal Title
  
  Biochem Biophys Res Commun 351
  
  Pages: 1048-1053
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18590061
[Journal Article] Neutrophil elastase induces IL-8 gene expression in lung epithelial cell2006
- Author(s)
  Kuwahara I, Lillehoi EP, Hisatsune A, Lu W, Isohama Y., Miyata T, Kim KC
- Journal Title
  
  Am J Physiol Lung Cell Physiol (In press)
- Data Source
  KAKENHI-PROJECT-16590053
[Journal Article] Neutrophil elastase stimulates MUC1 gene expression through increased Sp1 binding to the MUC1 promoter.2005
- Author(s)
  Kuwahara I, Lillehoi EP, Hisatsune A, Lu W, Isohama Y., Miyata T, Kim KC
- Journal Title
  
  Am J Physiol Lung Cell Physiol 289
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16590053
[Journal Article] Neutrophil elastase stimulates MUC1 gene expression through increased Spl binding to the MUC1 promoter.2005
- Author(s)
  Kuwahara I, Lillehoi EP, Hisatsune A, Lu W, Isohama T, Miyata T, Kim KC
- Journal Title
  
  Am J Physiol Lung Cell Physiol 289
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16590053
[Journal Article] Lipopolysaccharide changes the subcellular distribution of aquaporin 5 and increases plasma membrane water permeability in mouse lung epithelial cells.2005
- Author(s)
  Ohinata A, Nagai K, Nomura J, Hashimoto K, Hisatsune A, Miyata T, Isohama Y.
- Journal Title
  
  Biochem Biophys Res Commun. 326
  
  Pages: 521-526
- Data Source
  KAKENHI-PROJECT-16590053
[Journal Article] Lipopolysaccharide changes the subcellular distribution of aquaporin 5 and increases plasma membrane water permeability in mouse lung epithelial cells2005
- Author(s)
  Ohinata A, Nagai K, Nomura J, Hashimoto K, Hisatsune A, Miyata T, Isohama Y
- Journal Title
  
  Biochem Biophys Res Commun 326
  
  Pages: 521-526
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16590053
[Patent] アクアポリン3の発現調節剤2009
- Inventor(s)
  礒濱洋一郎,久恒昭哲,堀江一郎,香月博志
- Industrial Property Rights Holder
  熊本大学
- Industrial Property Number
  2009-178704
- Filing Date
  2009-07-31
- Data Source
  KAKENHI-PROJECT-20590084
[Patent] アクアポリン5の発現亢進剤2006
- Inventor(s)
  礒浜洋一郎, 宮田健, 久恒昭哲
- Industrial Property Rights Holder
  熊本大学
- Industrial Property Number
  2006-163070
- Filing Date
  2006-06-13
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-18590061
[Presentation] AQP5 expression enhances cytokine/chemokine expression by inflammatory stimuli in2014
- Author(s)
  坂本唯真、江川奈生、堀江一郎、久恒昭哲、香月博志、礒濱洋一郎
- Organizer
  第８７回日本薬理学会年会
- Place of Presentation
  宮城県仙台市仙台国際センター
- Data Source
  KAKENHI-PROJECT-23590108
[Presentation] Endogenous retinoid signaling after intracerebral hemorrhage in mice2014
- Author(s)
  松下英明、肱岡雅宣、石橋勇人、阿南順平、倉内祐樹、久恒昭哲、関貴弘、首藤紘一、香月博志
- Organizer
  第87回日本薬理学会年会
- Place of Presentation
  宮城県仙台市仙台国際センター, 他
- Data Source
  KAKENHI-PROJECT-23590108
[Presentation] High fat diet induces pathological change in hypothalamic orexin neurons2014
- Author(s)
  延永瑞希、小袋加奈絵、倉内祐樹、久恒昭哲、関貴弘、筒井正人、香月博志
- Organizer
  第８７回日本薬理学会年会
- Place of Presentation
  宮城県仙台市仙台国際センター
- Data Source
  KAKENHI-PROJECT-23590108
[Presentation] AQP5 expression enhances cytokine/chemokine expression by inflammatory stimuli in in airway epithelial cells2014
- Author(s)
  坂本唯真、江川奈生、堀江一郎、久恒昭哲、香月博志、礒濱洋一郎
- Organizer
  第87回日本薬理学会年会
- Place of Presentation
  宮城県仙台市仙台国際センター, 他
- Data Source
  KAKENHI-PROJECT-23590108
[Presentation] Endogenous retinoid signaling after intracerebral hemorrhage in mice2014
- Author(s)
  松下英明、肱岡雅宣、石橋勇人、阿南順平、倉内祐樹、久恒昭哲、関貴弘、首藤紘一、香月博志
- Organizer
  第８７回日本薬理学会年会
- Place of Presentation
  宮城県仙台市仙台国際センター
- Data Source
  KAKENHI-PROJECT-23590108
[Presentation] High fat diet induces pathological change in hypothalamic orexin neurons2014
- Author(s)
  延永瑞希、小袋加奈絵、倉内祐樹、久恒昭哲、関貴弘、筒井正人、香月博志
- Organizer
  第87回日本薬理学会年会
- Place of Presentation
  宮城県仙台市仙台国際センター, 他
- Data Source
  KAKENHI-PROJECT-23590108
[Presentation] 脳内出血モデルマウスにおける内因性レチノイドの役割2014
- Author(s)
  松下英明、肱岡雅宣、石橋勇人、阿南純平、倉内祐樹、久恒昭哲、関貴弘、首藤紘一、香月博志
- Organizer
  第87回日本薬理学会年会
- Place of Presentation
  仙台国際センター（仙台市）
- Data Source
  KAKENHI-PROJECT-24659118
[Presentation] アクアポリン5はサイトカイン産生を亢進する2014
- Author(s)
  坂本唯真、江川奈生、堀江一郎、久恒昭哲、香月博志、礒濱洋一郎
- Organizer
  第87回日本薬理学会年会
- Place of Presentation
  仙台国際センター（仙台市）
- Data Source
  KAKENHI-PROJECT-24659118
[Presentation] 高脂肪食は視床下部オレキシンニューロンにおける病理学的変化を誘導する2014
- Author(s)
  延永瑞希、小袋加奈絵、倉内祐樹、久恒昭哲、関貴弘、筒井正人、香月博志
- Organizer
  第87回日本薬理学会年会
- Place of Presentation
  仙台国際センター（仙台市）
- Data Source
  KAKENHI-PROJECT-24659118
[Presentation] 内包領域での軸索障害を焦点とした脳内出血病態進行メカニズムの解析2013
- Author(s)
  肱岡雅宜、松下英明、石橋勇人、久恒昭哲、礒濱洋一郎、香月博志
- Organizer
  日本薬学会第133年会
- Place of Presentation
  パシフィコ横浜
- Data Source
  KAKENHI-PROJECT-23590108
[Presentation] Mechanisms of retinoid-induced nNOS upregulation and neurite elongation in SH-SY5Y cells2013
- Author(s)
  Tatsuya Fujibayashi, Yuki Kurauchi, Akinori Hisatsune, Yoichiro Isohama, Hiroshi Katsuki
- Organizer
  第86回日本薬理学会年会
- Place of Presentation
  福岡国際会議場
- Data Source
  KAKENHI-PROJECT-23590108
[Presentation] モルモット気道粘液線毛輸送能の低下に対する清肺湯の作用2013
- Author(s)
  礒濱洋一郎，中川恭宏，久恒昭哲，香月博志
- Organizer
  第30回和漢医薬学会学術大会
- Place of Presentation
  金沢
- Data Source
  KAKENHI-PROJECT-23590109
[Presentation] 脳内出血モデルマウスにおける急性炎症に対するデキサメタゾンおよびレチノイド受容体作動薬Am80の作用2013
- Author(s)
  松下英明、肱岡雅宣、石橋勇人、久恒昭哲、礒濱洋一郎、首藤紘一、香月博志
- Organizer
  第86回日本薬理学会年会
- Place of Presentation
  福岡国際会議場(福岡市)
- Year and Date
  2013-03-22
- Data Source
  KAKENHI-PROJECT-24659118
[Presentation] 内包領域での軸索障害を焦点とした脳内出血病態進行メカニズムの解析2013
- Author(s)
  肱岡雅宜、松下英明、石橋勇人、久恒昭哲、礒濱洋一郎、香月博志
- Organizer
  日本薬学会第133年会
- Place of Presentation
  神奈川県横浜市パシフィコ横浜
- Data Source
  KAKENHI-PROJECT-23590108
[Presentation] マウス炎症性ドパミンニューロン変性モデルにおけるフェルラ酸の神経保護効果の解析2013
- Author(s)
  上松哲大、倉内祐樹、久恒昭哲、関貴弘、香月博志
- Organizer
  第66回日本薬理学会西南部会
- Place of Presentation
  福岡県福岡市福岡大学
- Year and Date
  2013-11-16
- Data Source
  KAKENHI-PROJECT-23590108
[Presentation] GABAによるミクログリア活性調節に関する研究2013
- Author(s)
  高岡侑一郎、久恒昭哲、小道由木子、倉内祐樹、関貴弘、香月博志
- Organizer
  第8回トランスポーター研究会年会
- Place of Presentation
  熊本大学薬学部(熊本市)
- Year and Date
  2013-06-15
- Data Source
  KAKENHI-PROJECT-24659118
[Presentation] Effects of dexamethasone and reinoic acid receptor agnoist Am80 on acute inflammation following intracerebral hemorrhage in mice2013
- Author(s)
  Hideaki Matsushita, Masanori Hijioka, Hayato Ishibashi, Akinori Hisatsune, Yoichiro Isohama, Koichi Syudo, Hiroshi Katsuki
- Organizer
  第86回日本薬理学会年会
- Place of Presentation
  福岡国際会議場
- Data Source
  KAKENHI-PROJECT-23590108
[Presentation] シェーグレン症候群患者血清中の抗アクアポリン5―自己抗体の存在とその意義に関する研究2013
- Author(s)
  礒濱洋一郎，本多裕亮，久恒昭哲，平木昭光，篠原　正德，牧野貴充，香月博志
- Organizer
  第12回九州シェーグレン症候群研究会
- Place of Presentation
  福岡
- Data Source
  KAKENHI-PROJECT-23590109
[Presentation] NO依存的な神経ペプチド折りたたみ不全亢進による視床下部オレキシンニューロンの選択的変性2013
- Author(s)
  香月博志、小袋加奈絵、延永瑞希、森岡弘志、久恒昭哲、下川宏明、筒井正人
- Organizer
  第13回日本NO学会学術集会
- Place of Presentation
  沖縄県医師会館
- Data Source
  KAKENHI-PROJECT-24659118
[Presentation] 内包領域での軸索傷害を焦点とした新規脳内出血病態進行メカニズム2013
- Author(s)
  肱岡雅宣、松下英明、石橋勇人、久恒昭哲、礒濱洋一郎、香月博志
- Organizer
  第36回日本神経科学大会
- Place of Presentation
  国立京都国際会館
- Data Source
  KAKENHI-PROJECT-24659118
[Presentation] マウス炎症生ドパミンニューロン変性モデルにおけるフェルラ酸の神経保護効果の解析2013
- Author(s)
  上松哲大、倉内祐樹、久恒昭哲、関貴弘、香月博志
- Organizer
  第66回日本薬理学会西南部会
- Place of Presentation
  福岡大学薬学部（福岡市）
- Data Source
  KAKENHI-PROJECT-24659118
[Presentation] 水チャネルaquaporin5はサイトカイン産生を亢進する2013
- Author(s)
  坂本唯真、江川奈生、久恒昭哲、香月博志、礒濱洋一郎
- Organizer
  第129回日本薬理学会関東部会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-23590109
[Presentation] GABAによるミクログリア活性調節に関する研究2013
- Author(s)
  高岡侑一郎、久恒昭哲、小道由木子、倉内祐樹、関貴弘、香月博志
- Organizer
  第8回トランスポーター研究会年会
- Place of Presentation
  熊本大学薬学部（熊本市）
- Data Source
  KAKENHI-PROJECT-24659118
[Presentation] 中脳ドパミンニューロン保護におけるNOを介するレチノイドシグナル2013
- Author(s)
  香月博志、藤林達也、倉内祐樹、久恒昭哲、首藤紘一
- Organizer
  第17回活性アミンに関するワークショップ
- Place of Presentation
  AOSSA福井(福井市)
- Year and Date
  2013-08-24
- Data Source
  KAKENHI-PROJECT-24659118
[Presentation] Mechanisms of retinoid-induced nNOS upregulation and neurite elongation in SH-SY5Y cells2013
- Author(s)
  Tatsuya Fujibayashi, Yuki Kurauchi, Akinori Hisatsune, Yoichiro Isohama, Hiroshi Katsuki
- Organizer
  第86回日本薬理学会年会
- Place of Presentation
  福岡県福岡市福岡国際会議場
- Data Source
  KAKENHI-PROJECT-23590108
[Presentation] SH-SY5Y細胞の神経突起伸長に関与するレチノイン酸受容体刺激誘導性nNOS発現亢進の機序解析2013
- Author(s)
  香月博志、藤林達也、倉内祐樹、久恒昭哲、首藤紘一
- Organizer
  第13回日本NO学会学術集会
- Place of Presentation
  沖縄県医師会館
- Data Source
  KAKENHI-PROJECT-24659118
[Presentation] レチノイン酸受容体刺激による神経型NO合成酵素発現亢進の機序2013
- Author(s)
  香月博志、藤林達也、倉内祐樹、久恒昭哲、首藤紘一
- Organizer
  日本レチノイド研究会第24回学術集会
- Place of Presentation
  星薬科大学百年記念館（東京）
- Data Source
  KAKENHI-PROJECT-24659118
[Presentation] 内包領域での軸索傷害を焦点とした脳内出血病態進行メカニズムの解析2013
- Author(s)
  肱岡雅宣、松下英明、石橋勇人、久恒昭哲、礒濱洋一郎、香月博志
- Organizer
  日本薬学会第133年会
- Place of Presentation
  パシフィコ横浜(横浜市)
- Year and Date
  2013-03-29
- Data Source
  KAKENHI-PROJECT-24659118
[Presentation] マウス炎症性ドパミンニューロン変性モデルにおけるフェルラ酸の神経保護効果の解析2013
- Author(s)
  上松哲大、倉内祐樹、久恒昭哲、関貴弘、香月博志
- Organizer
  第66回日本薬理学会西南部会
- Place of Presentation
  福岡大学薬学部(福岡市)
- Year and Date
  2013-11-16
- Data Source
  KAKENHI-PROJECT-24659118
[Presentation] ヒト神経芽腫SH-SY5Y細胞の神経突起伸長におけるシアル酸の関与2013
- Author(s)
  高橋周平、久恒昭哲、倉内祐樹、関貴弘、香月博志
- Organizer
  第8回トランスポーター研究会年会
- Place of Presentation
  熊本大学薬学部（熊本市）
- Data Source
  KAKENHI-PROJECT-24659118
[Presentation] Effects of dexamethasone and reinoic acid receptor agnoist Am80 on acute inflammation following intracerebral hemorrhage in mice2013
- Author(s)
  Hideaki Matsushita, Masanori Hijioka, Hayato Ishibashi, Akinori Hisatsune, Yoichiro Isohama, Koichi Syudo, Hiroshi Katsuki
- Organizer
  第86回日本薬理学会年会
- Place of Presentation
  福岡県福岡市福岡国際会議場
- Data Source
  KAKENHI-PROJECT-23590108
[Presentation] 高脂肪食は視床下部オレキシンニューロンにおける病理学的変化を誘導する2013
- Author(s)
  延永瑞希、小袋加奈絵、倉内祐樹、久恒昭哲、関貴弘、筒井正人、香月博志
- Organizer
  第87回日本薬理学会年会
- Place of Presentation
  仙台国際センター(仙台市)
- Year and Date
  2013-03-19
- Data Source
  KAKENHI-PROJECT-24659118
[Presentation] 脱シアル酸は、ミクログリアを活性化させる2012
- Author(s)
  久恒昭哲,笠田高志,高橋周平,礒濱洋一郎,香月博志
- Organizer
  第31回日本糖質学会
- Place of Presentation
  鹿児島県鹿児島市鹿児島市民文化ホール
- Data Source
  KAKENHI-PROJECT-23590108
[Presentation] 細菌性シアリダーゼに対す茶カテキンによる阻害作用2012
- Author(s)
  久恒昭哲, 他
- Organizer
  日本薬学会第132年会
- Place of Presentation
  札幌
- Year and Date
  2012-03-29
- Data Source
  KAKENHI-PROJECT-23590109
[Presentation] 脱シアル酸は、ミクログリアを活性化させる2012
- Author(s)
  久恒昭哲，笠田高志，高橋周平，礒濱洋一郎，香月博志
- Organizer
  第31回日本糖質学会
- Place of Presentation
  鹿児島市民文化ホール
- Data Source
  KAKENHI-PROJECT-23590108
[Presentation] 細菌性シアリダーゼに対する茶カテキンによる阻害作用2012
- Author(s)
  久恒昭哲ほか
- Organizer
  日本薬学会第132年会
- Place of Presentation
  北海道大学（札幌）
- Data Source
  KAKENHI-PROJECT-23590109
[Presentation] Involvement of bacterial sialidase in the development of bacterial meningitis2011
- Author(s)
  Akinori Hisatsune, Takashi Kasada, Shuhei Takahashi, Yoichiro Isohama, Hiroshi Katsuki
- Organizer
  Society for Neuroscience
- Place of Presentation
  米国ワシントンDC・コンベンションセンター
- Data Source
  KAKENHI-PROJECT-23590108
[Presentation] 細菌性シアリダーゼはミクログリアを活性化する2011
- Author(s)
  久恒昭哲，笠田高志，高橋周平，礒濱洋一郎，香月博志
- Organizer
  次世代を担う創薬・医療薬理シンポジウム2011
- Place of Presentation
  北里大学薬学部（東京都）
- Data Source
  KAKENHI-PROJECT-23590108
[Presentation] 抗MUC1抗体のEGF受容体シグナル伝達に対する影響2010
- Author(s)
  久恒昭哲(代表者)
- Organizer
  次世代を担う創薬・医療薬理シンポジウム2010
- Place of Presentation
  京都大学薬学部(京都市)
- Year and Date
  2010-09-11
- Data Source
  KAKENHI-PROJECT-20390026
[Presentation] シアリダーゼの肺上皮細胞における炎症性サトカイン発現に対する影響2009
- Author(s)
  久恒昭, ほか
- Organizer
  第29回気道分泌研究会
- Place of Presentation
  東京、八重洲富士屋ホオル
- Year and Date
  2009-04-25
- Data Source
  KAKENHI-PROJECT-20590084
[Presentation] ケラチノサイトの水チャネルaquaporin-3の発現を増加させる生薬の探索研究2009
- Author(s)
  堀江一郎, 久恒昭哲, 香月博志, 宮田健, 礒濱洋一郎
- Organizer
  第26回和漢医薬学会大会
- Place of Presentation
  千葉市
- Year and Date
  2009-08-30
- Data Source
  KAKENHI-PROJECT-19390193
[Presentation] シアリダーゼの肺上皮細胞における炎症性サトカイン発現に対する影響2009
- Author(s)
  久恒昭哲, ほか
- Organizer
  第29回気道分泌研究会
- Place of Presentation
  東京
- Year and Date
  2009-04-25
- Data Source
  KAKENHI-PROJECT-19390193
[Presentation] Influence of various point mutations on aqiaporin-1 mediated increase in CO_2 gas permeability2008
- Author(s)
  Takamatsu, F., Kondo, M., Hisatsune, A., Isohama, Y.
- Organizer
  The 128th annual meeting of the pharmaceutical society of Japan
- Place of Presentation
  Yokohama.
- Year and Date
  2008-03-28
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18590061
[Presentation] The inhibitory effects of inflammatory cytokines on aquaporin-3 expression2008
- Author(s)
  Horie, I., Isohama, Y., Hisatsune, A., Katsuki, H.
- Organizer
  The 128th annual meeting of the pharmaceutical society of Japan
- Place of Presentation
  Yokohama.
- Year and Date
  2008-03-28
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18590061
[Presentation] グリチルリチンの気道粘液産生抑制作用の薬理学的特性2008
- Author(s)
  礒濱洋一郎, 西本裕樹, 久恒昭哲, 香月博志, 宮田健
- Organizer
  第27回気道分泌研究会
- Place of Presentation
  東京
- Year and Date
  2008-04-12
- Data Source
  KAKENHI-PROJECT-19390193
[Presentation] Transcriptional regulation of aquaporin-5 gene in alveolar epithelial cells2007
- Author(s)
  Isohama, Y., Nomura, J., Mikami, Y., Hirie, I., Kurauchi, Y., Hisatsune, A.
- Organizer
  The 5th International Conference of Aquaporin
- Place of Presentation
  Nara.
- Year and Date
  2007-07-13
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18590061
[Presentation] Role of CpG methylation and Sp1 on cell type-specific expression of aquaporin-5 gene2007
- Author(s)
  Nomura, J., Hisatsune, A., Miyata, T., Isohama, Y.
- Organizer
  The 80th annual meeting of the Japanese pharmacological society
- Place of Presentation
  Nagoya.
- Year and Date
  2007-03-16
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18590061
[Presentation] Effect of Hochu-ekki-to,a Kampo medicine, on airway inflammation2007
- Author(s)
  Takei, H., Koguro, N., Hisatsune, A., Miyata, T., Katsuki, H., Isohama, Y.
- Organizer
  The 24th annual meeting of medical and pharmaceutical society for Wakan-yaku
- Place of Presentation
  Tovama.
- Year and Date
  2007-09-08
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18590061
[Presentation] Involvement of CpG methylation in cell type-specific expression of aquaporin-5 in alveolar type I epithelial cells2007
- Author(s)
  Isohama, Y., Nomura, J., Harada, S., Takei, H., Hisatsune, A., Miyata, T.
- Organizer
  The 6th annual meeting of new aspects in pulmonary surfactant biology and diseases
- Place of Presentation
  Sapporo
- Year and Date
  2007-07-07
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18590061
[Presentation] Inhibition of aquaporin-5 water channel by nitric oxide2007
- Author(s)
  Isohama, Y., Nagai, K., Arimatsu, A., Watanabe, M., Seto, M., Hisatsune, A., Miyata, T.
- Organizer
  The 27th annual meeting of the Japanese association for airway secretion research
- Place of Presentation
  Kagoshima
- Year and Date
  2007-04-14
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18590061
[Presentation] Glycyrrhizin inhibits NF-κB-dependent gene transcription and lung inflammation not through glucocorticoid receptor2007
- Author(s)
  Takei, H., Noshimoto, Y., Hisatsune, A., Miyata, T., Isohama, Y.
- Organizer
  The 80th annual meeting of the Japanese pharmacological society
- Place of Presentation
  Nagoya
- Year and Date
  2007-03-16
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18590061
[Presentation] 補中益気湯の抗炎症作用の薬理学的特性2007
- Author(s)
  武井啓典, 小黒夏子, 久恒昭哲, 香月博志, 宮田健, 礒濱洋一郎
- Organizer
  第24回和漢医薬学会大会
- Place of Presentation
  富山市
- Year and Date
  2007-09-08
- Data Source
  KAKENHI-PROJECT-19390193
[Presentation] Effects of aquaporin-1 and its point mutants on CO_2 gas permeability in Xenopus oocytes2007
- Author(s)
  Takamatsu, F., Kondo, M., Niomiya, A., Hisatsune, A., Katsuki, H.
- Organizer
  The 1st regional meeting Kyushu area of Japan transporter research association
- Place of Presentation
  Kumamoto
- Year and Date
  2007-11-24
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18590061
[Presentation] Nitric oxide stimulates aquaporin-5 endocytosis through cGMP-independent pathway in lung epithelial cells2007
- Author(s)
  Watanabe, M., Nagai, K., Arimatsu, A., Hisatsune, A., Miyata, T., Isohama, Y.
- Organizer
  The 80th annual meeting of the Japanese pharmacological society
- Place of Presentation
  Nagoya
- Year and Date
  2007-03-16
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18590061
[Presentation] All-trans retinoic acid increases expression of aquaporin-5 and plasma membrane water permeability via transactivation of Sp1 in mouse lung epithelial cells2007
- Author(s)
  Horie, I., Nomura, J., Hisatsune, A., Isohama, Y.
- Organizer
  The 5th International Conference of Aquaporin
- Place of Presentation
  Nara.
- Year and Date
  2007-07-13
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18590061
[Presentation] Effect of inflammatory cytokines on aquaporin-3 expression in keratinocytes2007
- Author(s)
  Horie, I., Isohama, Y., Hisatsune, A., Katsuki, H.
- Organizer
  The 60th regional meeting Seinan Area of the Japanese pharmacological society
- Place of Presentation
  Miyazaki
- Year and Date
  2007-11-22
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18590061
[Presentation] 気道上皮細胞における好中球エラスターゼによるMUClの発現調節機構2006
- Author(s)
  久恒昭哲(代表者)
- Organizer
  第26回気道分泌研究会
- Place of Presentation
  東京
- Year and Date
  2006-04-22
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-18590061
[Presentation] Transcriptional regulation of MUC1 gene by neutrophil elastase,through Sp1 binding to the MUC1 promoter2006
- Author(s)
  Hisatsune, A., Kalahari, I., Isohama, Y., Kim, KC., Miyata, T.
- Organizer
  The 26th annual meeting of the Japanese association for airway secretion research
- Place of Presentation
  Tokyo
- Year and Date
  2006-04-22
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18590061
[Presentation] SP-A-independent reuptake of surfactant phospholipids by alveolar type II cells2006
- Author(s)
  Isohama, Y., Okimoto, M., Hisatsune, A., Miyata, T.
- Organizer
  The 5th annual meeting of new aspects in pulmonary surfactant biology and diseases
- Place of Presentation
  Sapporo
- Year and Date
  2006-06-24
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18590061
[Presentation] Inhibition of water permeability through aquaporins by nitric oxide2006
- Author(s)
  Arimatsu, A., nagai, K., Hisatsune, A., Isohama, Y.
- Organizer
  The 23rd regional meeting Kyushu area of the pharmaceutical society of Japan
- Place of Presentation
  Kumamoto
- Year and Date
  2006-12-10
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18590061
[Presentation] Hypoxia-induced MUC1 gene expression in lung cancer cells2006
- Author(s)
  Mikami, Y., Hisatsune, A., Isohama, Y.
- Organizer
  The 23rd regional meeting Kyushu area of the pharmaceutical society of Japan
- Place of Presentation
  Kumamoto
- Year and Date
  2006-12-10
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18590061
[Presentation] Desensitization of toll-like receptor by MUC1.2006
- Author(s)
  Kuroiwa, A., Hisatsune, A., Kim, KC., Miyata, T., Isohama, Y.
- Organizer
  The 59th regional meeting Seinan Area of the Japanese pharmacological society
- Place of Presentation
  Naha.
- Year and Date
  2006-11-24
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18590061
[Presentation] マウス炎症性ドパミンニューロン変性モデルにおけるフェルラ酸の神経保護効果の解析
- Author(s)
  上松哲大、倉内祐樹、久恒昭哲、関貴弘、香月博志
- Organizer
  第６６回日本薬理学会西南部会
- Place of Presentation
  福岡県福岡市福岡大学
- Data Source
  KAKENHI-PROJECT-23590108

1. ISIHAMA Yoichiro (10240920)

# of Collaborated Projects: 6 results

# of Collaborated Products: 0 results
2. KATSUKI Hiroshi (40240733)

# of Collaborated Projects: 4 results

# of Collaborated Products: 38 results
3. MIYATA Takeshi (90040310)

# of Collaborated Projects: 3 results

# of Collaborated Products: 27 results
4. YOKOMIZO Kazumi (80240919)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
5. KURAUCHI Yuki

# of Collaborated Projects: 0 results

# of Collaborated Products: 3 results
6. 礒浜洋一郎

# of Collaborated Projects: 0 results

# of Collaborated Products: 55 results
7. 筒井正人

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
8. 松下英明

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
9. 赤池孝章

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
10. 澤智裕

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

HISATSUNE AKINORI 久恒 昭哲

久恒 昭哲 ヒサツネ アキノリ

HISATSUNE Akinori 久恒 昭哲

Research Projects

Research Products

Co-Researchers

精神症状の発現に関わるガングリオシドの作用Principal Investigator

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Low molecular weight compounds that direct microglia toward alternative activation

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Pathophysiological significance of sialic acid in CNSPrincipal Investigator

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A new function of aquaporin provide a insight into the molecular mechanism to inhibit inflammatory response

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Research on pathology and protection of intracerebral hemorrhage with special reference to microglial functions

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Sp3 and its regulatory effect of gene expression provide new insights to treat chronic obstructive pulmonary disease.

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Pharmacological study to cure mibyo, disease-oriented state

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Significance of increase in aquaporin 5 expression in respiratory system

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Toll-like受容体-5シグナル伝達に対する膜結合型ムチンMUCIの調節作用Principal Investigator

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CO_2 gas transporter in plasma membrane which is involved in gas exchange

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[Journal Article] Suppression of CXCL2 upregulation underlies the therapeutic effect of the retinoid Am80 on intracerebral hemorrhage in mice.2014

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[Journal Article] Aquaporin 5 increases keratinocyte-derived chemokine expression and NF-κB activity through ERK activation.2014

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[Journal Article] Suppression of CXCL2 upregulation underlies the therapeutic effect of the retinoid Am80 on intracerebral hemorrhage in mice2014

Author(s)

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[Journal Article] Nitric oxide mediates selective degeneration of hypothalamic orexin neurons through dysfunction of protein disulfide isomerase2013

HISATSUNE AKINORI 久恒昭哲

久恒昭哲ヒサツネアキノリ

HISATSUNE Akinori 久恒昭哲