Hari Yoshiyuki 張功幸

… Alternative Names

張功幸ハリヨシユキ

HARI Yoshiyuki 張功幸

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Researcher Number	50347423
Other IDs
Affiliation (Current)	2025: 徳島文理大学, 薬学部, 教授
Affiliation (based on the past Project Information) *help	2017 – 2023: 徳島文理大学, 薬学部, 教授 2014: 大阪大学, 大学院薬学系研究科, 准教授 2012 – 2014: 大阪大学, 薬学研究科(研究院), 准教授 2013: 大阪大学, 薬学研究科, 特任准教授 2009 – 2011: Osaka University, 薬学研究科, 特任准教授 … More 2010: Osaka University, 大学院・薬学研究科, 特任准教授 2005: 名古屋市立大学, 大学院薬学研究科, 助手 2004: 名古屋市立大学, 大学院・薬学研究科, 助手 Less
Review Section/Research Field	Principal Investigator Basic Section 37010:Bio-related chemistry / Chemical pharmacy / Bio-related chemistry / Chemistry related to living body / Complex systems Except Principal Investigator General pharmacology / Complex systems
Keywords	Principal Investigator 核酸化学 / 有機化学 / 有機合成化学 / 修飾オリゴ核酸 / アンチセンス核酸 / オリゴ核酸上の化学反応 / コンジュゲートオリゴ核酸 / アシルシラン / ベンゾフラン / インダゾール … More / ベンズアゼピン / トリメチルシリルジアゾメタン / 複素環合成 / イソボルネオール / アミノアルコール / 立体配座 / 不斉反応 / キラル触媒 … More Except Principal Investigator プロテオミクス / 生体膜 / リン酸化プロテオミクス / 比較定量プロテオミクス / シグナル情報伝達系 / 輸送系 / チャネル / 受容体 / 生物学 / 生物物理 / 薬物動態学 / 代謝 / 全身循環 / 薬物動態 / 不整脈 / 心臓 / 生物物理学 / 生理学 / システム生物学 Less

核酸塩基部をsyn配座固定したプリンヌクレオシドの開発と核酸高次構造の制御Principal Investigator
- Principal Investigator
  
  張功幸
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 37010:Bio-related chemistry
- Research Institution
  Tokushima Bunri University
Development of modified nucleic acid possessing RNase H activity for antisense oligonucleotides without phosphorothioate (PS) modificationPrincipal Investigator
- Principal Investigator
  
  Hari Yoshiyuki
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 37010:Bio-related chemistry
- Research Institution
  Tokushima Bunri University
Development of a pinpoint functionalization method of nucleic acidsPrincipal Investigator
- Principal Investigator
  
  Hari Yoshiyuki
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Bio-related chemistry
- Research Institution
  Tokushima Bunri University
Development of site-specific conversion method of nucleobase in mRNAPrincipal Investigator
- Principal Investigator
  
  HARI Yoshiyuki
- Project Period (FY)
  2012 – 2013
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Chemistry related to living body
- Research Institution
  Osaka University
Identification of plasma membrane leucine receptor and elucidation of its link to mTOR signaling pathway
- Principal Investigator
  
  KANAI Yoshikatsu
- Project Period (FY)
  2012 – 2013
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  General pharmacology
- Research Institution
  Osaka University
Establishment of Integrative Multi-level Systems Biology and its Applications
- Principal Investigator
  
  KURACHI YOSHIHISA
- Project Period (FY)
  2010 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
- Review Section
  
  Complex systems
- Research Institution
  Osaka University
Development of synthetic methodology to supply materials for understanding of physiological systemPrincipal Investigator
- Principal Investigator
  
  HARI Yoshiyuki
- Project Period (FY)
  2010 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
- Review Section
  
  Complex systems
- Research Institution
  Osaka University
Practical synthetic reactions using functionalized trimethylsilyldiazomethanesPrincipal Investigator
- Principal Investigator
  
  HARI Yoshiyuki
- Project Period (FY)
  2009 – 2010
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Chemical pharmacy
- Research Institution
  Osaka University
厳密な不斉反応場の構築を指向した立体配座固定型触媒の開発Principal Investigator
- Principal Investigator
  
  張功幸
- Project Period (FY)
  2004 – 2005
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Chemical pharmacy
- Research Institution
  Nagoya City University

[Book] Software Platform for Metabolic Network Reconstruction of Mycobacterium tuberculosis. Systems Biology of Tuberculosis.2013
- Author(s)
  Samik Ghosh, Yukiko Matsuoka, Yoshiyuki Asai, Hiroaki Kitano, Anshu Bhardwaj, Vinod Scaria, Rohit Vashisht, Anup Shah, Anupam Kumar Mondal, Priti Vishnoi, Kumari Sonal, Akanksha Jain, Priyanka Priyadarshini, Kausik Bhattacharyya, Vikas Kumar, Anurag Passi, Pratibha Sharma, Samir Brahmachari
- Total Pages
  226
- Publisher
  Springer
- Data Source
  KAKENHI-ORGANIZER-22136001
[Book] Software Platform for Metabolic Network Reconstruction of Mycobacterium tuberculosis.(書籍タイトル:Systems Biology of Tubarculosis,)2011
- Author(s)
  Samik Ghosh, Yukiko Matsuoka, Yoshiyuki Asai, Hiroaki Kitano, Anshu Bhardwaj, Vinod Scaria, Rohit Vashisht, Anup Shah, Anupam Kumar Mondal, Priti Vishnoi, Kumari Sonal, Akanksha Jain, Priyanka Priyadarshini, Kausik Bhattacharyya, Vikas Kumar, Anurag Passi, Pratibha Sharma, Open Source Drug Discovery Consortium, Samir Brahmachari
- Publisher
  Springer(In press)
- Data Source
  KAKENHI-ORGANIZER-22136001
[Book] Science of Synthesis Knowledge Updates 2010/42011
- Author(s)
  Y.Hari, T.Aoyama, T.Shioiri
- Publisher
  Georg Thieme Verlag
- Data Source
  KAKENHI-PLANNED-22136006
[Book] Therapeutic Oligonucleotides : Methods and Protocols2011
- Author(s)
  Y.Hari, T.Kodama, T.Imanishi, S.Obika
- Publisher
  Humana Press
- Data Source
  KAKENHI-PLANNED-22136006
[Journal Article] Synthesis and hybridization properties of iridium(III) polypyridyl complex-conjugated oligonucleotide2020
- Author(s)
  Yuta Ito, Koichi Mizuno, Kohei Domoto, Yoshiyuki Hari
- Journal Title
  
  Nucleos. Nucleot. Nucleic Acids
  
  Volume: 39 Issue: 1-3 Pages: 69-81
- DOI
  10.1080/15257770.2019.1690150
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K05943
[Journal Article] Triplex- and Duplex-Forming Abilities of Oligonucleotides Containing 2′-Deoxy-5-trifluoromethyluridine and 2′-Deoxy-5-trifluoromethylcytidine2017
- Author(s)
  Y. Ito, M. Matsuo, T. Osawa, Y. Hari
- Journal Title
  
  Chemical and Pharmaceutical Bulletin
  
  Volume: 65 Issue: 10 Pages: 982-988
- DOI
  10.1248/cpb.c17-00530
- NAID
  130006109934
- ISSN
  0009-2363, 1347-5223
- Language
  English
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K05943, KAKENHI-PROJECT-17K15431
[Journal Article] Kinetic study of the binding of triplex-forming oligonucleotides containing partial cationic modifications to double-stranded DNA2014
- Author(s)
  Hari, Y.; Ijitsu, S.; Akabane-Nakata, M.; Yoshida, T.; Obika, S.
- Journal Title
  
  Bioorg. Med. Chem. Lett.
  
  Volume: 24 Issue: 14 Pages: 3046-3049
- DOI
  10.1016/j.bmcl.2014.05.031
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PLANNED-22136006
[Journal Article] Synthesis of oligonucleotides containing N,N-disubstituted 3-deazacytosine nucleobases by post-elongation modification and their triplex-forming ability with double-stranded DNA2014
- Author(s)
  Akabane-Nakata, M.; Obika, S.; Hari, Y.
- Journal Title
  
  Org. Biomol. Chem.
  
  Volume: 12 Issue: 44 Pages: 9011-9015
- DOI
  10.1039/c4ob01760a
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PLANNED-22136006
[Journal Article] The ability of 1-aryltriazole-containing nucleobases to recognize a TA base pair in triplex DNA2014
- Author(s)
  Hari, Y.; Nakahara, M.; Ijitsu, S.; Obika, S.
- Journal Title
  
  Heterocycles
  
  Volume: 88 Issue: 1 Pages: 377-386
- DOI
  10.3987/com-13-s(s)33
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-22136006
[Journal Article] Base pair recognition ability of 2-(methylamino)pyrimidin-4-yl nucleobase in parallel triplex DNA2014
- Author(s)
  Hari, Y.; Kashima, S.; Matsuda, Y.; Sakata, A.; Takamine, R.; Ijitsu, S.; Obika, S.
- Journal Title
  
  Heterocycles
  
  Volume: 90 Issue: 1 Pages: 432-441
- DOI
  10.3987/com-14-s(k)41
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PLANNED-22136006
[Journal Article] 2,4 -BNA bearing a chiral guanidkhopyrroi rdine-containing nucreobase with potent ability to recognize the CG base pair in a parallel-motif DNA trinlex2013
- Author(s)
  Yoshiyuki Hari, Masaaki Akabane, Satoshi Obika
- Journal Title
  
  Chemical Communications
  
  Volume: 49 Issue: 67 Pages: 7421-7423
- DOI
  10.1039/c3cc44030c
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-12J00463, KAKENHI-PLANNED-22136006
[Journal Article] Triplex-forming ability of oligonucleotides containing 1-aryl-1,2,3-triazole nucleobases linked via a two atom-length spacer2013
- Author(s)
  Hari, Y.; Nakahara, M.; Obika, S.
- Journal Title
  
  Bioorg. Med. Chem.
  
  Volume: 21 Issue: 17 Pages: 5583-5588
- DOI
  10.1016/j.bmc.2013.05.034
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-22136006
[Journal Article] Synthesis and properties of 2'-O,4'-C-ethyleneoxy bridged 5-methyluridine2013
- Author(s)
  Hari, Y.; Morikawa, T.; Osawa, T.; Obika, S.
- Journal Title
  
  Org. Lett.
  
  Volume: 15 Issue: 14 Pages: 3702-3705
- DOI
  10.1021/ol401566r
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-22136006
[Journal Article] Synthesis and properties of thymidines with six-membered amide bridge2013
- Author(s)
  Hari, Y.; Osawa, T.; Kotobuki, Y.; Shrestha, A. R.; Yahara, A.; Obika, S.
- Journal Title
  
  Bioorg. Med. Chem.
  
  Volume: 21 Issue: 14 Pages: 4405-4412
- DOI
  10.1016/j.bmc.2013.04.049
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-22136006, KAKENHI-PROJECT-24249007
[Journal Article] Base-pair recognition ability of hydroxyphenyl nucleobases in parallel triplex DNA2013
- Author(s)
  Hari, Y.; Kashima, S.; Inohara, H.; Ijitsu, S.; Imanishi, T.; Obika, S.
- Journal Title
  
  Tetrahedron
  
  Volume: 69 Issue: 31 Pages: 6381-6391
- DOI
  10.1016/j.tet.2013.05.107
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-22136006
[Journal Article] Synthesis and duplex-forming ability of oligonucleotides containing 4’-carboxythymidine analogs2012
- Author(s)
  Hari, Y.; Osawa, T.; Obika, S.
- Journal Title
  
  Org. Biomol. Chem.
  
  Volume: 10 Issue: 48 Pages: 9639-9649
- DOI
  10.1039/c2ob26712h
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-22136006
[Journal Article] Towards the sequence-selective recognition of double-stranded DNA containing pyrimidine-purine interruptions by triplex-forming oligonucleotides2012
- Author(s)
  Hari, Y.; Obika, S.; Imanishi, T.
- Journal Title
  
  Eur. J. Org. Chem.
  
  Volume: 2012 Issue: 15 Pages: 2875-2887
- DOI
  10.1002/ejoc.201101821
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-22136006
[Journal Article] A 2-AMINO-6-METHYLPYRIDIN-5-YL NUCLEOBASE FOR GC BASE PAIR RECOGNITION IN THE PARALLEL TRIPLEX DNA2012
- Author(s)
  中原基
- Journal Title
  
  Heterocycles
  
  Volume: 86 Issue: 2 Pages: 1135-1146
- DOI
  10.3987/com-12-s(n)68
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-12J03385, KAKENHI-PLANNED-22136006
[Journal Article] Synthesis and properties of a bridged nucleic acid with a perhydro-1,2-oxazin-3-one ring2011
- Author(s)
  A.R.Shrestha, Y.Hari, A.Yahara, T.Osawa, S.Obika
- Journal Title
  
  J.Org.Chem.
  
  Volume: 76 Pages: 9891-9899
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-22136006
[Journal Article] A 4-[(3R,4R)-Dihydroxypyrrolidino]pyrimidin-2-one Nucleobase for a CG Base Pair in Triplex DNA2011
- Author(s)
  Y.Hari, M.Akabane, Y.Hatanaka, M.Nakahara, S.Obika
- Journal Title
  
  Chem.Commun.
  
  Volume: (印刷中)
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-22136006
[Journal Article] Facile synthesis of 1-methyl-1H-benzo[b]azepines from 1-methylquinolinium iodides and diazo(trimethylsilyl)methylmagnesium bromide2010
- Author(s)
  M.Morita, Y.Hari, T.Aoyama
- Journal Title
  
  Synthesis
  
  Pages: 4221-4227
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21790021
[Journal Article] Facile synthesis of 1-methyl-1 H-benzo[b]azepines from 1-methylquinolinium iodides and diazo(trimethylsilyl)methylmagnesium bromide2010
- Author(s)
  M.Morita, Y.Hari, T.Aoyama
- Journal Title
  
  Synthesis
  
  Pages: 4221-4227
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21790021
[Journal Article] Facile synthesis of 2-unsubstituted benzofuran-3-carboxylates using diazo(trimethylsilyl)methylmagnesium bromide2009
- Author(s)
  Y.Hari, R.Kondo, K.Date, T.Aoyama
- Journal Title
  
  Tetrahedron 65
  
  Pages: 8708-8713
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21790021
[Journal Article] Facile two-step synthesis of 3-substituted indazoles using diazo (trimethylsilyl) methylmagnesium bromide2009
- Author(s)
  Y.Hari, R.Sone, T.Aoyama
- Journal Title
  
  Org.Biomol.Chem. Vol.7
  
  Pages: 2804-2808
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21790021
[Journal Article] Facile two-step synthesis of 3-substituted indazoles using diazo(trimethylsilyl)methylmagnesium bromide2009
- Author(s)
  Y.Hari, R.Sone, T.Aoyama
- Journal Title
  
  Org.Biomol.Chem. 7
  
  Pages: 2804-2808
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21790021
[Journal Article] Facile synthesis of 2-unsubstituted benzofuran-3-carboxylates using diazo (trimethylsilyl) methylmagnesium bromide2009
- Author(s)
  Y.Hari, R.Kondo, K.Date, T.Aoyama
- Journal Title
  
  Tetrahedron Vol.65
  
  Pages: 8708-8713
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21790021
[Journal Article] Efficient Synthesis of o-Alkynyl-N-pivaloylanilines from o-Acyl-N-pivaloylanilines and Lithium Trimethylsilyldiazomethane2006
- Author(s)
  Yoshiyuki Hari, Tomoki Kanie, Toyohiko Aoyama
- Journal Title
  
  Tetrahedron Letters vol 47
  
  Pages: 1137-1139
- Data Source
  KAKENHI-PROJECT-16790016
[Journal Article] Enantioselective Addition of Diethylzinc to Aldehydes Catalyzed by (1R,2R)-10-(Dialkylamino)isoborneols2005
- Author(s)
  Yoshiyuki Hari, Toyohiko Aoyama
- Journal Title
  
  Synthesis (印刷中)
- Data Source
  KAKENHI-PROJECT-16790016
[Journal Article] New Synthesis of t-Butyl 1,2-Dihydro-1-oxaazulene-3-carboxylates Using Lithium Trimethylsilyldiazomethane2005
- Author(s)
  Susumu Tsuchida, Yoshiyuki Hari, Toyohiko Aoyama
- Journal Title
  
  Heterocycles vol 65
  
  Pages: 2667-2674
- NAID
  40006934826
- Data Source
  KAKENHI-PROJECT-16790016
[Journal Article] Regioselective Synthesis of 1-Arylindazoles via N-Arylation of 3-Trimethylsilylindazoles2005
- Author(s)
  Yoshiyuki Hari, Yoshimichi Shoji, Toyohiko Aoyama
- Journal Title
  
  Tetrahedron Letters vol 46
  
  Pages: 3771-3774
- Data Source
  KAKENHI-PROJECT-16790016
[Journal Article] Facile, One-Pot Synthesis of Bicyclic 2-Pyridones from Acyl Isocyanates, N-Phenylmaleimide and Trimethylsilyldiazomethane2005
- Author(s)
  Yoshiyuki Hari, Tomoe Iguchi, Toyohiko Aoyama
- Journal Title
  
  Synthesis
  
  Pages: 2147-2150
- Data Source
  KAKENHI-PROJECT-16790016
[Journal Article] Facile One-Pot Synthesis of Di- and Tri-Substituted Furans From Acyl Isocyanates Using Trimethylsilyldiazomethane2004
- Author(s)
  Yoshiyuki Hari, Tomoe Iguchi, Toyohiko Aoyama
- Journal Title
  
  Synthesis No.9
  
  Pages: 1359-1362
- Data Source
  KAKENHI-PROJECT-16790016
[Journal Article] New Synthesis of 3-Substituted Indoles Using Lithium Trimethylsilyldiazomethane2004
- Author(s)
  Takashi Miyagi, Yoshiyuki Hari, Toyohiko Aoyama
- Journal Title
  
  Tetrahedron Letters Vol.45/No.33
  
  Pages: 6303-6305
- Data Source
  KAKENHI-PROJECT-16790016
[Journal Article] New Synthesis of 3-Substituted Indazoles from 3-Trimethylsilylindazole2004
- Author(s)
  Yoshiyuki Hari, Yoshimichi Shoji, Toyohiko Aoyama
- Journal Title
  
  Synthesis No.8
  
  Pages: 1183-1186
- Data Source
  KAKENHI-PROJECT-16790016
[Patent] 架橋型ヌクレオシドおよびヌクレオチド2014
- Inventor(s)
  張功幸，大澤昂志，小比賀聡
- Industrial Property Rights Holder
  大阪大学
- Industrial Property Rights Type
  特許
- Industrial Property Number
  2014-248316
- Filing Date
  2014-12-08
- Data Source
  KAKENHI-PLANNED-22136006
[Patent] 架橋型ヌクレオシドおよびヌクレオチド2014
- Inventor(s)
  張功幸，大澤昂志，小比賀聡
- Industrial Property Rights Holder
  大阪大学
- Industrial Property Rights Type
  特許
- Industrial Property Number
  2014-156149
- Filing Date
  2014-07-31
- Data Source
  KAKENHI-PLANNED-22136006
[Presentation] アデノシンアナログを含む核酸高次構造の評価系の構築2024
- Author(s)
  花城帆乃佳，伊藤勇太，渕　靖史，張　功幸
- Organizer
  日本薬学会第144年会
- Data Source
  KAKENHI-PROJECT-23K04936
[Presentation] 1',4'-架橋型チミジンを含むオリゴ核酸の合成とその物性評価2023
- Author(s)
  後藤優大、伊藤勇太、渕　靖史、張　功幸
- Organizer
  日本薬学会第143年会
- Data Source
  KAKENHI-PROJECT-20K05716
[Presentation] 4'-置換チミジンを含むオリゴヌクレオチドのRNase H活性とヌクレアーゼ耐性能2022
- Author(s)
  石川楓子、渕靖史、伊藤勇太、張功幸
- Organizer
  日本薬学会第142年会
- Data Source
  KAKENHI-PROJECT-20K05716
[Presentation] イリジウム錯体を導入したオリゴ核酸の合成とその応用2019
- Author(s)
  堂本晃平，伊藤勇太，大澤昂志，張　功幸
- Organizer
  第2回日本核酸化学会中四国地区セミナー
- Data Source
  KAKENHI-PROJECT-17K05943
[Presentation] イリジウム錯体コンジュゲートオリゴ核酸の合成2019
- Author(s)
  堂本晃平，伊藤勇太，大澤昂志，張　功幸
- Organizer
  日本薬学会第139年会
- Data Source
  KAKENHI-PROJECT-17K05943
[Presentation] Synthesis of iridium-conjugated oligonucleotides and their application2019
- Author(s)
  伊藤勇太，堂本晃平，大澤昂志，張　功幸
- Organizer
  日本核酸医薬学会第5回年会
- Data Source
  KAKENHI-PROJECT-17K05943
[Presentation] イリジウム錯体コンジュゲートオリゴ核酸の合成2019
- Author(s)
  堂本晃平、伊藤勇太、大澤昂志、張　功幸
- Organizer
  日本薬学会第139年会
- Data Source
  KAKENHI-PROJECT-17K05943
[Presentation] 三重鎖核酸形成においてＴＡ塩基対を選択的に認識する新規人工核酸の開発2014
- Author(s)
  井實慎，張功幸，小比賀聡
- Organizer
  日本薬学会第134年会
- Place of Presentation
  熊本大学（熊本県）
- Data Source
  KAKENHI-PLANNED-22136006
[Presentation] スルフィン酸アナログを用いたC→U変換反応2014
- Author(s)
  廣瀬望，張功幸，小比賀聡
- Organizer
  第63回日本薬学会近畿支部総会・大会
- Place of Presentation
  同志社女子大学（京都府）
- Data Source
  KAKENHI-PROJECT-24655152
[Presentation] 5-メチルシトシンを含む二重鎖DNAとの安定な三重鎖核酸形成を目指した人工核酸ユニットの設計と合成2014
- Author(s)
  高嶺竜太朗，松田侑也，小比賀聡，張　功幸
- Organizer
  第64回日本薬学会近畿支部総会・大会
- Place of Presentation
  京都薬科大学
- Year and Date
  2014-10-11
- Data Source
  KAKENHI-PLANNED-22136006
[Presentation] Synthesis and Triplex-Forming Ability of Oligonucleotides Bearing Hydroxyphenyl Nucleobases2013
- Author(s)
  Shin Ijitsu, Yoshiyuki Hari, Satoshi Kashima, Satoshi Obika
- Organizer
  The 2nd HD Physiology International Symposium
- Place of Presentation
  丸の内 My Plaza Hall（東京都）
- Data Source
  KAKENHI-PLANNED-22136006
[Presentation] スルフィン酸アナログを用いたC→U変換反応2013
- Author(s)
  廣瀬望, 張功幸, 小比賀聡
- Organizer
  第63回日本薬学会近畿支部総会・大会
- Place of Presentation
  京都
- Year and Date
  2013-10-12
- Data Source
  KAKENHI-PROJECT-24655152
[Presentation] 2'-O,4'-C-エチレンオキシ架橋型5-メチルウリジンの合成と機能評価2013
- Author(s)
  張功幸，森河朋彦，大澤昂志，小比賀聡
- Organizer
  第23回アンチセンスシンポジウム
- Place of Presentation
  徳島大学（徳島県）
- Data Source
  KAKENHI-PLANNED-22136006
[Presentation] Synthesis and Property of a Novel 2',4'-BNA Analog with 2,6-Dioxabicyclo[3.2.1]oct-3-ene Skeleton2013
- Author(s)
  Takashi Osawa, Yoshiyuki Hari, Satoshi Obika
- Organizer
  The 2nd HD Physiology International Symposium
- Place of Presentation
  丸の内 My Plaza Hall（東京都）
- Data Source
  KAKENHI-PLANNED-22136006
[Presentation] 正電荷を有する人工核酸の三重鎖核酸形成速度に与える影響2013
- Author(s)
  井實慎，張功幸，小比賀聡
- Organizer
  第39回反応と合成の進歩シンポジウム
- Place of Presentation
  九州大学（福岡県）
- Data Source
  KAKENHI-PLANNED-22136006
[Presentation] Design, Synthesis and Properties of 2’-O,4’-C-Ethyleneoxy Bridged 5-Methyluridine Analog2013
- Author(s)
  Yoshiyuki Hari, Tomohiko Morikawa, Satoshi Obika
- Organizer
  9th AFMC International Medicinal Chemistry Symposium (AIMECS 13)
- Place of Presentation
  Grand Hotel Taipei（台湾）
- Data Source
  KAKENHI-PLANNED-22136006
[Presentation] Synthesis and Property of a Novel 2',4'-BNA with 2,6-Dioxabicyclo[3.2.1]oct-3-ene Skeleton2013
- Author(s)
  Takashi Osawa, Yoshiyuki Hari, Satoshi Obika
- Organizer
  The 40th International Symposium on Nucleic Acids Chemistry (ISNAC2013)
- Place of Presentation
  神奈川大学（神奈川県）
- Data Source
  KAKENHI-PLANNED-22136006
[Presentation] N-アルキル置換2-オキサ-5-アザビシクロ[2.2.1]ヘプタン-6-オン骨格を有する架橋型人工核酸の開発2012
- Author(s)
  矢原愛子, 張功幸, 大澤昂志, 山口雅樹, A.R.Shrestha, 寿悠太朗, 小比賀聡
- Organizer
  第132回日本薬学会年会
- Place of Presentation
  北海道大学高等教育振興機構(札幌)
- Year and Date
  2012-03-29
- Data Source
  KAKENHI-PLANNED-22136006
[Presentation] 分子内水素結合形成を基盤とした新規架橋型人工核酸の開発2012
- Author(s)
  大澤昂志, 張功幸, 小比賀聡
- Organizer
  第132回日本薬学会年会
- Place of Presentation
  北海道大学高等教育振興機構(札幌)
- Year and Date
  2012-03-31
- Data Source
  KAKENHI-PLANNED-22136006
[Presentation] Modification methods of oligonucleotides : Post-elongation modification2012
- Author(s)
  M.Akabane, Y.Hari, M.Nakahara, S.Obika
- Organizer
  The 1^<th> HD Physiology International Symposium
- Place of Presentation
  東京大学(東京)
- Year and Date
  2012-01-21
- Data Source
  KAKENHI-PLANNED-22136006
[Presentation] CG 塩基対を含む二重鎖DNA と安定な三重鎖核酸を形成する人工核酸の開発2012
- Author(s)
  張功幸，赤羽昌明，小比賀聡
- Organizer
  第62回日本薬学会近畿支部総会・大会
- Place of Presentation
  武庫川女子大学（兵庫県）
- Year and Date
  2012-10-20
- Data Source
  KAKENHI-PLANNED-22136006
[Presentation] Development of a novel bridged nucleic acid based on intramolecular hydrogen bond formation2012
- Author(s)
  Osawa, T.; Hari, Y.; Obika, S.
- Organizer
  The 7th Seoul-Kyoto-Osaka Joint Symposium onPharmaceutical Sciences for Young Scientists
- Place of Presentation
  京都大学（京都府）
- Year and Date
  2012-05-25
- Data Source
  KAKENHI-PLANNED-22136006
[Presentation] Synthesis of new conformationally-restricted nucleosides2012
- Author(s)
  A.Fujisaka, Y.Hari, T.Imanishi, S.Obika
- Organizer
  The 1^<th> HD Physiology International Symposium
- Place of Presentation
  東京大学(東京)
- Year and Date
  2012-01-21
- Data Source
  KAKENHI-PLANNED-22136006
[Presentation] Synthesis and duplex-forming ability of oligonucleotides containing 2'-substituted thymidines with carboxylic acid equivalents at the 4'-position2012
- Author(s)
  Hari, Y.; Osawa, T.; Obika, S.
- Organizer
  13th Tetrahedron Symposium (Asia Edition)
- Place of Presentation
  台北（台湾）
- Year and Date
  2012-11-27
- Data Source
  KAKENHI-PLANNED-22136006
[Presentation] クリックケミストリーを活用した新規人工核酸塩基の開発と三重鎖形成核酸への応用2012
- Author(s)
  中原基，張功幸，小比賀聡
- Organizer
  第３８回反応と合成の進歩シンポジウム
- Place of Presentation
  タワーホール船橋（東京都）
- Year and Date
  2012-11-05
- Data Source
  KAKENHI-PLANNED-22136006
[Presentation] New synthetic methods of heterocyclic compounds using trimethylsilyldiazomethane2012
- Author(s)
  Y.Hari, T.Aoyama
- Organizer
  The 1^<th> HD Physiology International Symposium
- Place of Presentation
  東京大学(東京)
- Year and Date
  2012-01-21
- Data Source
  KAKENHI-PLANNED-22136006
[Presentation] Efforts towards recognition of a CG base pair in triplex DNA2011
- Author(s)
  Y.Hari, M.Akabane, M.Nakahara, S.Obika
- Organizer
  8^<th> AFMC International Medicinal Chemistry Symposium
- Place of Presentation
  京王プラザホテル(東京)
- Year and Date
  2011-12-01
- Data Source
  KAKENHI-PLANNED-22136006
[Presentation] 三重鎖核酸形成のためのTA塩基対認識塩基の開発2011
- Author(s)
  加島聖史、張功幸、井實慎、小比賀聡
- Organizer
  第61回日本薬学会近畿支部総会・大会
- Place of Presentation
  神戸学院大学(兵庫)
- Year and Date
  2011-10-22
- Data Source
  KAKENHI-PLANNED-22136006
[Presentation] Design and Synthesis of Novel 2',4'-Bridged Nucleic Acid with Perhydro 1,2-Oxazinone Ring2011
- Author(s)
  A.R.Shrestha, 張功幸, 矢原愛子, 大澤昂志, 小比賀聡
- Organizer
  第131回日本薬学会年会
- Place of Presentation
  静岡
- Year and Date
  2011-03-29
- Data Source
  KAKENHI-PLANNED-22136006
[Presentation] 2-オキサ-5-アザビシクロ[2.2.1]ヘプタン-6-オン骨格を有する架橋型人工核酸の開発2011
- Author(s)
  矢原愛子, 張功幸, 大澤昂志, 山口雅樹, A.R.Shrestha, 寿悠太朗, 小比賀聡
- Organizer
  第131回日本薬学会年会
- Place of Presentation
  静岡
- Year and Date
  2011-03-29
- Data Source
  KAKENHI-PLANNED-22136006
[Presentation] アミド型六員環架橋構造を持つ新規人工核酸の合成と機能評価(2)2011
- Author(s)
  寿悠太朗、張功幸、矢原愛子、大澤昂志、小比賀聡
- Organizer
  第61回日本薬学会近畿支部総会・大会
- Place of Presentation
  神戸学院大学(兵庫)
- Year and Date
  2011-10-22
- Data Source
  KAKENHI-PLANNED-22136006
[Presentation] プリン塩基を有する2',4'-BNA^<NC>の合成2010
- Author(s)
  藤坂朱紀, 張功幸, 田熊寛子, 逢娟娟, 今西武, 小比賀聡
- Organizer
  第20回アンチセンスシンポジウム
- Place of Presentation
  兵庫
- Data Source
  KAKENHI-PLANNED-22136006
[Presentation] 三重鎖核酸形成によりCG塩基対を認識するシチジンアナログ(2)2010
- Author(s)
  張功幸, 赤羽昌明, 小比賀聡
- Organizer
  第60回日本薬学会近畿支部総会・大会
- Place of Presentation
  大阪
- Year and Date
  2010-10-30
- Data Source
  KAKENHI-PLANNED-22136006
[Presentation] パラレル型三重鎖核酸形成におけるCG塩基対認識を目的としたシチジン誘導体の合成および評価2010
- Author(s)
  赤羽昌明, 張功幸, 小比賀聡
- Organizer
  第20回アンチセンスシンポジウム
- Place of Presentation
  兵庫
- Data Source
  KAKENHI-PLANNED-22136006
[Presentation] 三重鎖核酸形成における非天然塩基ピリジンの塩基対認識能2010
- Author(s)
  畑中優里, 張功幸, 小比賀聡
- Organizer
  第60回日本薬学会近畿支部総会・大会
- Place of Presentation
  大阪
- Year and Date
  2010-10-30
- Data Source
  KAKENHI-PLANNED-22136006
[Presentation] N,N-ジ置換シトシン塩基を含むオリゴヌクレオチドの合成および三重鎖核酸形成能2010
- Author(s)
  張功幸, 赤羽昌明, 小比賀聡
- Organizer
  第36回反応と合成の進歩シンポジウム
- Place of Presentation
  愛知
- Year and Date
  2010-11-01
- Data Source
  KAKENHI-PLANNED-22136006
[Presentation] 三重鎖核酸形成によりCG塩基対を認識するシチジンアナログ(1)2010
- Author(s)
  赤羽昌明, 張功幸, 畑中優里, 小比賀聡
- Organizer
  第60回日本薬学会近畿支部総会・大会
- Place of Presentation
  大阪
- Year and Date
  2010-10-30
- Data Source
  KAKENHI-PLANNED-22136006
[Presentation] N,N-Disubstituted Cytosine Nucleobases for Recognition of a CG Base Pair in Triplex DNA Formation2010
- Author(s)
  Y.Hari, M.Akabane, Y.Hatanaka, M.Nakahara, S.Obika
- Organizer
  The 5th International Conference on Cutting-Edge Organic Chemistry in Asia (ICCEOCA-5)
- Place of Presentation
  Hsinchu, Taiwan
- Data Source
  KAKENHI-PLANNED-22136006
[Presentation] アミド型6員環架橋構造を持つ新規人工核酸の合成と機能評価2010
- Author(s)
  大澤昂志, 張功幸, 矢原愛子, A.R.Shrestha, 寿悠太朗, 山口雅樹, 小比賀聡
- Organizer
  第60回日本薬学会近畿支部総会・大会
- Place of Presentation
  大阪
- Year and Date
  2010-10-30
- Data Source
  KAKENHI-PLANNED-22136006
[Presentation] トリメチルシリルジアゾメタンのMgBr塩を用いたα-ヒドロキシアシルシランの合成2009
- Author(s)
  曽根良介, 張功幸, 青山豊彦
- Organizer
  第35回反応と合成の進歩シンポジウム
- Place of Presentation
  金沢
- Year and Date
  2009-11-07
- Data Source
  KAKENHI-PROJECT-21790021
[Presentation] トリメチルシリルジアゾメタンのMgBr塩を用いたα-ヒドロキシアシルシランの合成2009
- Author(s)
  曽根良介, 張功幸, 青山豊彦
- Organizer
  第35回反応と合成の進歩シンポジウム
- Place of Presentation
  金沢市文化ホール(金沢)
- Year and Date
  2009-11-07
- Data Source
  KAKENHI-PROJECT-21790021
[Presentation] indazoles using [3+2]cycloaddition reactions of 2-diazo-2-(trimethylsilyl)ethanols2009
- Author(s)
  Y.Hari, R.Sone, T.Aoyama
- Organizer
  22^<nd> International Congress on Heterocyclic Chemistry
- Place of Presentation
  St John's, Canada
- Year and Date
  2009-08-03
- Data Source
  KAKENHI-PROJECT-21790021
[Presentation] Facile synthesis of 3-substituted pyrazoles and indazoles using [3+2] cycloaddition reactions of 2-diazo-2- (trimethylsilyl) ethanols2009
- Author(s)
  Y.Hari, R.Sone, T.Aoyama
- Organizer
  22_<nd> International Congress on Heterocyclic Chemistry
- Place of Presentation
  The Delta Hotel (St John's, Canada)
- Year and Date
  2009-08-03
- Data Source
  KAKENHI-PROJECT-21790021
[Presentation] Development of new post-elongation modification method towards finding a nucleobase for TA base pair recognition in triplex DNA
- Author(s)
  Yuya Matsuda, Shin Ijitsu, Ryutaro Takamine, Akihiro Sakata, Satoshi Obika, Yoshiyuki Hari
- Organizer
  The 41th International Symposium on Nucleic Acids Chemistry (ISNAC2014)
- Place of Presentation
  北九州国際会議場
- Year and Date
  2014-11-05 – 2014-11-07
- Data Source
  KAKENHI-PLANNED-22136006
[Presentation] 二重鎖DNAの標的化を可能にする機能性人工核酸の開発
- Author(s)
  張　功幸
- Organizer
  日本薬学会第１３５年会
- Place of Presentation
  神戸学院大学
- Year and Date
  2015-03-25 – 2015-03-28
- Invited
- Data Source
  KAKENHI-PLANNED-22136006
[Presentation] 新規架橋型核酸3'-O,4'-C-エチレンオキシ-5-メチルウリジンの開発
- Author(s)
  土肥正和，大澤昂志，小比賀聡，張　功幸
- Organizer
  日本薬学会第１３５年会
- Place of Presentation
  神戸学院大学
- Year and Date
  2015-03-25 – 2015-03-28
- Data Source
  KAKENHI-PLANNED-22136006

1. KURACHI YOSHIHISA (30142011)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
2. INOUE Ryuji (30232573)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
3. YAMASHITA Fumiyoshi (30243041)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
4. SUZUKI Hiroshi (80206523)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
5. KITANO Hiroaki (80500256)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
6. OHTSUKI Sumio (60323036)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. AMANO Akira (60252491)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. KINOSHITA Kengo (60332293)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. MAKITA Naomasa (00312356)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. ISHIKAWA Yoshihiro (40305470)

# of Collaborated Projects: 1 results

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11. HONJO Haruo (70262912)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
12. NAKAZAWA Kazuo (50198058)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
13. OKUNO Yasushi (20283666)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
14. KUSUHARA Hiroyuki (00302612)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
15. KAGECHIKA Hiroyuki (20177348)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
16. YOSHIMITSU Takehiko (30301576)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
17. KODAMA Tetsuya (00432443)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
18. KOJIMA Naoto (90420413)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
19. KANAI Yoshikatsu (60204533)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
20. NAGAMORI Shushi (90467572)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
21. OHGAKI Ryuichi (20467525)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
22. 中原基

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Hari Yoshiyuki 張 功幸

張 功幸 ハリ ヨシユキ

HARI Yoshiyuki 張 功幸

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核酸塩基部をsyn配座固定したプリンヌクレオシドの開発と核酸高次構造の制御Principal Investigator

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Development of modified nucleic acid possessing RNase H activity for antisense oligonucleotides without phosphorothioate (PS) modificationPrincipal Investigator

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Development of a pinpoint functionalization method of nucleic acidsPrincipal Investigator

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Development of site-specific conversion method of nucleobase in mRNAPrincipal Investigator

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Identification of plasma membrane leucine receptor and elucidation of its link to mTOR signaling pathway

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Establishment of Integrative Multi-level Systems Biology and its Applications

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Development of synthetic methodology to supply materials for understanding of physiological systemPrincipal Investigator

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Practical synthetic reactions using functionalized trimethylsilyldiazomethanesPrincipal Investigator

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厳密な不斉反応場の構築を指向した立体配座固定型触媒の開発Principal Investigator

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[Book] Software Platform for Metabolic Network Reconstruction of Mycobacterium tuberculosis. Systems Biology of Tuberculosis.2013

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[Book] Software Platform for Metabolic Network Reconstruction of Mycobacterium tuberculosis.(書籍タイトル:Systems Biology of Tubarculosis,)2011

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[Book] Science of Synthesis Knowledge Updates 2010/42011

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[Book] Therapeutic Oligonucleotides : Methods and Protocols2011

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[Journal Article] Synthesis and hybridization properties of iridium(III) polypyridyl complex-conjugated oligonucleotide2020

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Hari Yoshiyuki 張功幸

張功幸ハリヨシユキ

HARI Yoshiyuki 張功幸