yatsuhashi hiroshi 八橋弘

… Alternative Names

Researcher Number	50360855
Other IDs	https://orcid.org/0000-0001-5487-3403
External Links
Affiliation (Current)	2022: 独立行政法人国立病院機構(長崎医療センター臨床研究センター), 臨床研究センター, 副院長
Affiliation (based on the past Project Information) *help	2006: 独立行政法人国立病院機構(長崎医療センター臨床研究センター), 治療研究部, 部長 2006: Nagasaki Medical Center, Clinical Research Center, Director of the Department of Therapeutic Research, 臨床研究センター・治療研究部, 部長 2005: 独立行政法人国立病院機構(長崎医療センター臨床研究センター), 治療研究部, 治療研究部長 2005: National Hospital Organization, Nagasaki Medical Center, Clinical Research Center, Department of Therapeutic Research, Director, 臨床研究センター, 治療研究部長 2004: National Hospital Organization Nagasaki Medical Center, Clinical Research Center, Department of Therapeutic Research, Director, 長崎医療センター・臨床研究センター, 治療研究部長 … More
Review Section/Research Field	Principal Investigator Gastroenterology Except Principal Investigator Gastroenterology / 膠原病・アレルギー・感染症内科学 / General surgery
Keywords	Principal Investigator C型慢性肝炎 / IFNシグナル / IFN治療 / IFNレセプター / Chronic Hepatitis C / IFN Signal / IFN Management / IFN Receptor Except Principal Investigator 原発性胆汁性肝硬変 / 抗gp210抗体 … More

Identification of new molecular targets and the study for the mechanism of bile ducts-and hepatocyte-destruction in primary biliary cirrhosis
- Principal Investigator
  
  NAKAMURA Minoru
- Project Period (FY)
  2005 – 2006
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Gastroenterology
- Research Institution
  National Hospital Organization(NHO) Nagasaki Medical Center
C型肝炎ウイルスコア蛋白と結合するDNA修復酵素の遺伝子クローニング
- Principal Investigator
  
  ISHIBASHI Hiromi
- Project Period (FY)
  2003 – 2004
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  Gastroenterology
- Research Institution
  Department of Clinical Research, National Hospital Organization Nagasaki Medical Center
Single nucleotide polymorphisms in interferon signaling pathway and immuno system response to interferon treatment in hepatitis C patientsPrincipal Investigator
- Principal Investigator
  
  YATSUHASHI Hiroshi
- Project Period (FY)
  2003 – 2004
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Gastroenterology
- Research Institution
  National Hospital Organization Nagasaki Medical Center, Clinical Research Center
Construction of antibody-library to identify etiology-associated-antigen
- Principal Investigator
  
  NAKAMURA Minoru
- Project Period (FY)
  2003 – 2004
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  膠原病・アレルギー・感染症内科学
- Research Institution
  National Hospital Organization Nagasaki Medical Center, Clinical Research Center
Clinical application of bioartifical liver support and heopatocyte transplantation using human hepatocytes
- Principal Investigator
  
  FUJIOKA Hikaru
- Project Period (FY)
  2003 – 2005
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  General surgery
- Research Institution
  National Hospital Organization Nagasaki Medical Center Clinical Research Center

All 2006 2005 2004 2003 2002

All Journal Article Book

[Book] IFN Receptor and IFN Signals : In Therapy for Viral Hepatitis and Prevent ion of Hepatocellular Carcinoma(M.Omata, K.Okita (Eds.))2004
- Author(s)
  H.Yatsuhashi
- Publisher
  Springer-Verlag
- Data Source
  KAKENHI-PROJECT-15590710
[Book] IFN Receptor and IFN Signals : In Therapy for Viral Hepatitis and Prevention of Hepatocellular Carcinoma(M.Omata, K.Okita(Eds.))2004
- Author(s)
  H.Yatsuhashi
- Publisher
  Springer-Verlag
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15590710
[Journal Article] Immunosuppressive FK506 inhibits matrix metalloproteinase-9 induction in TNF-alpha-stimulated human hepatic stellate cells.2006
- Author(s)
  Migita K, Maeda Y, Abiru S, Nakamura M, Komori A, Yokoyama T, Takii Y, Mod T, Yatsuhashi H, Eguchi K, Ishibashi H.
- Journal Title
  
  Life Sci. 78(21)
  
  Pages: 2510-2515
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17590696
[Journal Article] Serum cytokine and soluble cytokine receptor levels in patients with non-alcoholic steatohepatitis.2006
- Author(s)
  Abiru S, Migita K, Maeda Y, Daikoku M, Ito M, Ohata K, Nakamura M, Komori A, Yano K, Yatsuhashi H, Eguchi K, Ishibashi H.
- Journal Title
  
  Liver Int. 26(1)
  
  Pages: 39-45
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17590696
[Journal Article] Serum levels of interleukin-6 and its soluble receptors in patients with hepatitis C virus infection.2006
- Author(s)
  Migita K, Abiru S, Maeda Y, Daikoku M, Ohata K, Nakamura M, Komori A, Yano K, Yatsuhashi H, Eguchi K, Ishibashi H.
- Journal Title
  
  Human Immunol. 67(1-2)
  
  Pages: 27-32
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17590696
[Journal Article] Increased expression of nuclear envelope gp210 antigen in small bile ducts in primary biliary cirrhosis.2006
- Author(s)
  Nakamura M, Takii Y, Ito M, Komori A, Yokoyama T, Shimizu-Yoshida Y, Koyabu M, Matsuyama M, Mori T, Kamihira T, Daikoku M, Migita K, Yatsuhashi H, Nozaki N, Shimoda S, Ishibashi H
- Journal Title
  
  J.Autoimmunity 26(2)
  
  Pages: 138-145
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15591371
[Journal Article] IgA class antibodies to 2-oxo-acid dehydrogenase complex are not predictive markers of histopathological progression in primary biliary cirrhosis.2006
- Author(s)
  Omagari K, Kadokawa Y, Nakamura M, Akazawa S, Ohba K, Ohnita K, Mizuta Y, Daikoku M, Yatsuhashi H, Ishibashi H, Kohno S.
- Journal Title
  
  Autoimmunity 39(2)
  
  Pages: 107-112
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17590696
[Journal Article] Polymorhisms of interleukin-1beta in Japanese patients with hepatitis B virus infection.2006
- Author(s)
  Migita K, Maeda Y, Abiru S, Nakamura M, Komori A, Miyazoe S, Nakao K, Yatsuhashi H, Eguchi K, Ishibashi H.
- Journal Title
  
  J Hepatol. (Epub ahead of print)
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17590696
[Journal Article] Relationship between serum resistin concentrations and inflammatory markers in patients with type 2 diabetes mellitus.2006
- Author(s)
  Hui-Bing H, Migita K, Miyashita T, Maeda Y, Nakamura M, Yatsuhashi H, Ishibashi H, Eguchi K, Kimura H.
- Journal Title
  
  Metabolism. 55
  
  Pages: 1670-1673
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17590696
[Journal Article] HLA-DRB1^*04 alleles in Japanese rheumatoid arthritis patients with AA amyloidosis.2006
- Author(s)
  Migita K, Nakamura T, Maeda Y, Miyashita T, Origuchi T, Yatsuhashi Y, Nakamura M, Ishibashi H, Eguchi K.
- Journal Title
  
  J Rheumatol. 33
  
  Pages: 2120-2123
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17590696
[Journal Article] Increased expression of nuclear envelope gp210 antigen in small bile ducts in primary biliary cirrhosis.2006
- Author(s)
  Nakamura M, Takii Y, Ito M, Komori A, Yokoyama T, Shimizu-Yoshida Y, Koyabu M, Matsuyama M, Mori T, Kamihira T, Daikoku M, Migita K, Yatsuhashi H, Nozaki N, Shimoda S, Ishibashi H.
- Journal Title
  
  J.Autoimmunity 26(2)
  
  Pages: 138-145
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17590696
[Journal Article] Immunosuppressant FK506 inhibits matrix metalloproteinase-9 induction in TNF-alpha-stimulated human hepatic stellate cells.2006
- Author(s)
  Migita K, Maeda Y, Abiru S, Nakamura M, Komori A, Yokoyama T, Takii Y, Mori T, Yatsuhashi H, Eguchi K, Ishibashi H
- Journal Title
  
  Life Sci. 78(21)
  
  Pages: 2510-2515
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15591371
[Journal Article] Human intrahepatic biliary epithelial cells function in innate immunity by producing IL-6 and IL-8 via the TLR4-NF-kappaB and -MAPK signaling pathways.2006
- Author(s)
  Yokoyama T, Komori A, Nakamura M, Takii Y, Kamihira T, Shimoda S, Mori T, Fujiwara S, Koyabu M, Taniguchi K, Fujioka H, Migita K, Yatsuhashi H, Ishibashi H
- Journal Title
  
  Liver Int. 26(4)
  
  Pages: 467-476
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15591371
[Journal Article] Enhanced expression of type I interferon and toll-like receptor-3 in primary biliary cirrhosis.2005
- Author(s)
  Takii Y, Nakamura M, Ito M, Yokoyama T, Komori A, Shimizu-Yoshida Y, Nakao R, Kusumoto K, Nagaoka S, Yano K, Abiru S, Ueki T, Matsumoto T, Daikoku M, Taniguchi K, Fujioka H, Migita K, Yatsuhashi H, Nakashima M, Harada M, Ishibashi H
- Journal Title
  
  Lab Invest. 85(7)
  
  Pages: 908-920
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15591371
[Journal Article] Antibody titer to gp210-C terminal peptide as a clinical parameter for monitoring primary biliary cirrhosis.2005
- Author(s)
  Nakamura M, Shimizu-Yoshida Y, Takii Y, Komori A, Yokoyama T, Ueki T, Daikoku M, Yano K, Matsumoto T, Migita K, Yatsuhashi H, Ito M, Masaki N, Adachi H, Watanabe Y, Nakamura Y, Saoshiro T, Sodeyama T, Koga M, Shimoda S, Ishibashi H
- Journal Title
  
  J.Hepatol. 42(3)
  
  Pages: 386-392
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15591371
[Journal Article] Natural interferon α treatment and interferon α receptor 2 levels in a cute hepatitis C2004
- Author(s)
  Ohata K, Yano K, Yatsuhashi H, Daikoku M, Koga M, Eguchi K, Yano M
- Journal Title
  
  Dig Dis Sci 49・2
  
  Pages: 289-294
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15590710
[Journal Article] Natural interferon α treatment and interferon α receptor 2 levels in acute hepatitis C2004
- Author(s)
  Ohata K, Yano K, Yatsuhashi H, Daikoku M, Koga M, Eguchi K, Yano M
- Journal Title
  
  Dig Dis.Sci 49・2
  
  Pages: 289-294
- Data Source
  KAKENHI-PROJECT-15590710
[Journal Article] A low-density cDNA microarray with a unique reference RNA : pattern recognition analysis for IFN efficacy prediction to HCV as a model.2004
- Author(s)
  Daiba A, Inaba N, Ando S, Kajiyama N, Yatsuhashi H, Terasaki H, Ito A, Ogasawara M, Abe A, Yoshioka J, Hayashida K, Kaneko S, Kohara M, Ito S.
- Journal Title
  
  Biochem Biophys Res Commun 315(4)
  
  Pages: 1088-1096
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15590710
[Journal Article] B型肝炎可燃ウイルス(HBV) B型肝炎ウイルスのゲノム疫学2004
- Author(s)
  八橋弘
- Journal Title
  
  日本臨牀ウイルス性肝炎(下)-基礎・臨床研究の進歩 62・増刊号8
  
  Pages: 186-189
- Data Source
  KAKENHI-PROJECT-15590710
[Journal Article] B型肝炎ウイルス(HBV) B型肝炎ウイルスのゲノム疫学2004
- Author(s)
  八橋弘
- Journal Title
  
  日本臨牀ウイルス性肝炎(下) -基礎・臨床研究の進歩 62・増刊号8
  
  Pages: 186-189
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15590710
[Journal Article] IFN Receptor and IFN Signals2004
- Author(s)
  H.Yatsuhashi
- Journal Title
  
  Therapy for Viral Hepatitis and Prevention of Hepatocellular Carcinoma, (M.Omata, K.Okita (Eds.))(Springer-Verlag)
  
  Pages: 176-185
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15590710
[Journal Article] わが国のC型肝炎の現状,日本の肝癌は,なぜ多いのか2004
- Author(s)
  八橋弘
- Journal Title
  
  日本消化器学会雑誌 101(6)
  
  Pages: 578-584
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15590710
[Journal Article] B型肝炎ウイルス(HBV),B型肝炎ウイルスのゲノム疫学2004
- Author(s)
  八橋弘
- Journal Title
  
  日本臨牀ウイルス性肝炎(下)-基礎・臨床研究の進歩 62(増刊号8)
  
  Pages: 186-189
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15590710
[Journal Article] 特集/B型肝炎診療の進歩 IFN治療の滴応と問題点2004
- Author(s)
  八橋弘
- Journal Title
  
  肝胆膵 49・4
  
  Pages: 471-477
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15590710
[Journal Article] 特集/B型肝炎診療の進歩,IFN治療の適応と問題点2004
- Author(s)
  八橋弘
- Journal Title
  
  肝胆膵 49(4)
  
  Pages: 471-477
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15590710
[Journal Article] Natural interferon atreatment and interferon areceptor 2 levels in acute hepatitis C.2004
- Author(s)
  Ohata K, Yano K, Yatsuhashi H, Daikoku M, Koga M, Eguchi K, Yano M.
- Journal Title
  
  Dig Dis Sci 49(2)
  
  Pages: 289-294
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15590710
[Journal Article] 特集/B型肝炎診療の進歩 IFN治療の適応と問題点2004
- Author(s)
  八橋弘
- Journal Title
  
  肝胆膵 49・4
  
  Pages: 471-477
- Data Source
  KAKENHI-PROJECT-15590710
[Journal Article] A low-density cDNA microarray with a unique reference RNA : pattern recognition analysis for IFN efficacy prediction to HCV as a model2004
- Author(s)
  Daiba A, Inaba N, Ando S, Kajiyama N, Yatsuhashi H, Terasaki H, Ito A, Ogasawara M, Abe A, Yoshioka J, Hayashida K, Kaneko S, Kohara M, Ito S
- Journal Title
  
  Biochem Biophys Res Commun 315・4
  
  Pages: 1088-1096
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15590710
[Journal Article] わが国のC型肝炎の現状日本の肝癌は,なぜ多いのか2004
- Author(s)
  八橋弘
- Journal Title
  
  日本消化器病学会雑誌 101・6
  
  Pages: 578-584
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15590710
[Journal Article] Interleukin-10 promoter polymorphisms and liver fibrosis progression in patients with chronic hepatitis C in Japan2003
- Author(s)
  H.Hamada, H.Yatsuhashi, K.Yao, K.Arisawa, K.Nakao, M.Yano
- Journal Title
  
  Journal of Hepatology 39・3
  
  Pages: 457-458
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15590710
[Journal Article] Interleukin-10 promoter polymorphisms and liver fibrosis progression in patients with chronic hepatitis C in Japan.2003
- Author(s)
  H.Hamada, H.Yatsuhashi, K.Yano, K.Arisawa, K.Nakao, M.Yano
- Journal Title
  
  Journal of Hepatology 39(3)
  
  Pages: 457-458
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15590710
[Journal Article] Influence of Interleukin-10 Gene Promoter Polymorphisms on Disease Progression in Patients Chronically Infected With Hepatitis B Virus.2002
- Author(s)
  S.Miyazoe, K.Hamasaki, K.Nakata, Y.Kajiya, K.Kitajima, K.Nakao, M.Daikoku, H.Yatsuhashi, M.Koga, M.Yano, K.Eguchi
- Journal Title
  
  Am J Gastroentero 197(8)
  
  Pages: 2086-2092
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15590710
[Journal Article] Influence of Interleukin-10 Gene Promoter Polymorphisms on Disease Progression in Patients Chronically Infected With Hepatitis B Virus2002
- Author(s)
  S.Miyazoe, K.Hamasaki, K.Nakata, Y.Kajiya, K.Kitajima, K.Nakao, M.Daikoku, H.Yatsuhashi, M.Koga, M.Yano, K.Eguchi
- Journal Title
  
  Am J Gastroenterol 97・8
  
  Pages: 2086-2092
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15590710

1. ISHIBASHI Hiromi (80127969)

# of Collaborated Projects: 5 results

# of Collaborated Products: 13 results
2. NAKAMURA Minoru (40217906)

# of Collaborated Projects: 5 results

# of Collaborated Products: 13 results
3. FUJIOKA Hikaru (00264226)

# of Collaborated Projects: 3 results

# of Collaborated Products: 2 results
4. YANO Koji (60360856)

# of Collaborated Projects: 2 results

# of Collaborated Products: 7 results
5. KOMORI Atsumasa (50234901)

# of Collaborated Projects: 1 results

# of Collaborated Products: 5 results
6. MIGITA Kiyoshi (60264214)

# of Collaborated Projects: 1 results

# of Collaborated Products: 7 results

yatsuhashi hiroshi 八橋 弘

YATSUHASHI Hiroshi 八橋 弘

Research Projects

Research Products

Co-Researchers

Identification of new molecular targets and the study for the mechanism of bile ducts-and hepatocyte-destruction in primary biliary cirrhosis

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

C型肝炎ウイルスコア蛋白と結合するDNA修復酵素の遺伝子クローニング

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Single nucleotide polymorphisms in interferon signaling pathway and immuno system response to interferon treatment in hepatitis C patientsPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Construction of antibody-library to identify etiology-associated-antigen

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Clinical application of bioartifical liver support and heopatocyte transplantation using human hepatocytes

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Book] IFN Receptor and IFN Signals : In Therapy for Viral Hepatitis and Prevent ion of Hepatocellular Carcinoma(M.Omata, K.Okita (Eds.))2004

Author(s)

Publisher

Data Source

[Book] IFN Receptor and IFN Signals : In Therapy for Viral Hepatitis and Prevention of Hepatocellular Carcinoma(M.Omata, K.Okita(Eds.))2004

Author(s)

Publisher

Description

Data Source

[Journal Article] Immunosuppressive FK506 inhibits matrix metalloproteinase-9 induction in TNF-alpha-stimulated human hepatic stellate cells.2006

Author(s)

Journal Title

Description

Data Source

[Journal Article] Serum cytokine and soluble cytokine receptor levels in patients with non-alcoholic steatohepatitis.2006

Author(s)

Journal Title

Description

Data Source

[Journal Article] Serum levels of interleukin-6 and its soluble receptors in patients with hepatitis C virus infection.2006

Author(s)

Journal Title

Description

Data Source

[Journal Article] Increased expression of nuclear envelope gp210 antigen in small bile ducts in primary biliary cirrhosis.2006

Author(s)

Journal Title

Description

Data Source

[Journal Article] IgA class antibodies to 2-oxo-acid dehydrogenase complex are not predictive markers of histopathological progression in primary biliary cirrhosis.2006

Author(s)

Journal Title

Description

Data Source

[Journal Article] Polymorhisms of interleukin-1beta in Japanese patients with hepatitis B virus infection.2006

Author(s)

Journal Title

Description

Data Source

[Journal Article] Relationship between serum resistin concentrations and inflammatory markers in patients with type 2 diabetes mellitus.2006

Author(s)

Journal Title

Description

Data Source

[Journal Article] HLA-DRB1^*04 alleles in Japanese rheumatoid arthritis patients with AA amyloidosis.2006

yatsuhashi hiroshi 八橋弘

YATSUHASHI Hiroshi 八橋弘