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WATANABE KENJI  渡辺 賢二

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… Alternative Names

WATANABE Kenji  渡辺 賢二

渡辺 賢二  ワタナベ ケンジ

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Researcher Number 50360938
Other IDs
Affiliation (Current) 2025: 静岡県立大学, 薬学部, 教授
Affiliation (based on the past Project Information) *help 2015 – 2024: 静岡県立大学, 薬学部, 教授
2009 – 2015: University of Shizuoka, 薬学部, 准教授
2004: 北大, (連合)農学研究科(研究院), 助手
Review Section/Research Field
Principal Investigator
Medium-sized Section 38:Agricultural chemistry and related fields / Chemical biology / Science and Engineering / Broad Section F / Transformative Research Areas, Section (II) / Basic Section 38040:Bioorganic chemistry-related / Transition State Control / Chemical biology / Bioproduction chemistry/Bioorganic chemistry / Applied biochemistry … More
Except Principal Investigator
… More Science and Engineering / Transformative Research Areas, Section (II) / Basic Section 09030:Childhood and nursery/pre-school education-related / Basic Section 08030:Family and consumer sciences, and culture and living-related / Eating habits / Natural medicines / Biomolecular chemistry / Genetics/Genome dynamics / Living organism molecular science Less
Keywords
Principal Investigator
生合成 / 天然物 / 天然物化学 / コリバクチン / 大腸がん / 酵素反応機構 / 大腸菌 / 異種発現 / 抗生物質 / がん化学予防法 … More / 孵化誘因物質 / 農薬 / ステロール / ソラノエクレピンA / 遺伝毒性物質 / 天然物生合成 / 抗腫瘍性抗生物質 / フマギリン / 遺伝子治療 / 反応機構 / Diels-Alder反応 / 糸状菌 / 遺伝子 / 物質生産 / 酵素 / ペプチド / ジャガイモ シストセンチュウ / モノクローナル抗体 / 発がんメカニズム / 植物 / 予知生合成 / ステロイド / ジャガイモシストセンチュウ / 生合成メカニズム / ナス科植物 / Micro-Tom / シストセンチュウ孵化誘因物質 / solanoeclepin A / ジャガイモシストセンチュウ孵化誘因物質 / ヒト細胞発現系 / 抗がん剤 / 生合成遺伝子異種発現 / fumagillin / 遺伝子治療法 / 細胞内de novo合成 / 細菌叢 / 大腸ガン / 化学構造解析 / 計算化学 / 酸化反応 / epoxidation / FAD / monooxygenase / spiro-carbon / [4+2]環化反応 / 生合成酵素 / Diels-Alderase / 反応メカニズム / Diels-Alder / アポトーシス / 生物的全合成 / 生物活性 / 生合成遺伝子 / 自己抗生物質 / レトロウイルスベクター / HeLa細胞 / 生合成遺伝子発現 / 機能発現 / 異種宿主発現 / ゲノム情報 / Aspoquinolone / 生合 / 微量天然物 / キノコ / テルペノイド / 生合成リデザイン / 生理活性物質 / 担子菌 / 遺伝子クラスター / リデザイン / タンパク質構造解析 / 活性物質 / 酵素反応 / 遷移状態 / 反応遷移状態 / オクタリン骨格 / Dels-Alder反応 / 腸内細菌 / シンセティックバイオロジー / ケミカルバイオロジー / 脂質 / 診断マーカー / 腸内細菌層 / 遺伝性毒素 / 非リボソーム依存性ペプチド / 酵母 / サフラマイシン / 化学生物学 … More
Except Principal Investigator
天然物化学 / 生合成 / 反応機構 / 腸内細菌叢 / 生物分子科学 / 生合成工学 / 合成生物学 / 生合成リデザイン / 生物合成 / 植物 / バイオテクノロジー / 酵素 / 酵素工学 / ゲノム / 情報科学 / 計算科学 / 有機合成 / 国際交流 / 天然有機化合物 / 生物活性物質 / 保育所 / 無作為化介入試験 / 親子 / 介入試験 / 沖縄県 / 行動変容 / 肥満 / 食育 / 社会経済因子 / 母子関係 / 小児肥満因子 / 沖縄の食習慣 / 断面研究 / 小児肥満 / 家庭・地域 / 母子相互関係 / 社会経済因子(沖縄) / 生物分子化学 / 分子代謝学 / 炎症 / 大腸菌 / ケミカルバイオロジー / シンセティックバイオロジー / 光合成細菌 / シアノバクテリア / 天然物 / コルジセピン / キノコ / 微生物 / 酵素化学 / 生物活性 / 抗生物質 / 物質生産 / OAC / polyketide synthase / Type III PKS / X線結晶構造解析 / 閉環酵素 / タンパク質結晶構造解析 / ポリケタイド / 組換え機構 / 遺伝学 / 突然変異 / 遺伝子 / 逆遺伝学 / 分子遺伝 / プレニル基転移酵素 / テレトニン / テルペン環化酵素 / 分子多様性 / メロテルペノイド / biosynthesis / 生理活性 Less
  • Research Projects

    (25 results)
  • Research Products

    (196 results)
  • Co-Researchers

    (50 People)
  •  Toward engineered biosynthesis of drugs in human cellsPrincipal Investigator

    • Principal Investigator
      渡辺 賢二
    • Project Period (FY)
      2022 – 2024
    • Research Category
      Grant-in-Aid for Challenging Research (Exploratory)
    • Review Section
      Medium-sized Section 38:Agricultural chemistry and related fields
    • Research Institution
      University of Shizuoka
  •  予知生合成科学・研究総括班

    • Principal Investigator
      葛山 智久
    • Project Period (FY)
      2022 – 2026
    • Research Category
      Grant-in-Aid for Transformative Research Areas (A)
    • Review Section
      Transformative Research Areas, Section (II)
    • Research Institution
      The University of Tokyo
  •  Uncovering a biosynthetic pathway of plant natural product solanoeclepin APrincipal Investigator

    • Principal Investigator
      渡辺 賢二
    • Project Period (FY)
      2022 – 2026
    • Research Category
      Grant-in-Aid for Transformative Research Areas (A)
    • Review Section
      Transformative Research Areas, Section (II)
    • Research Institution
      University of Shizuoka
  •  Understanding a mechanism of an onset of colorectal cancer by colibactin and finding compounds inhibiting colibactin biosynthetic enzymesPrincipal Investigator

    • Principal Investigator
      渡辺 賢二
    • Project Period (FY)
      2022 – 2026
    • Research Category
      Grant-in-Aid for Scientific Research (S)
    • Review Section
      Broad Section F
    • Research Institution
      University of Shizuoka
  •  Understanding a mechanism of an onset of colorectal cancer by colibactin and finding a inhibitor to the biosynthetic enzymesPrincipal Investigator

    • Principal Investigator
      渡辺 賢二
    • Project Period (FY)
      2022
    • Research Category
      Grant-in-Aid for Scientific Research (A)
    • Review Section
      Medium-sized Section 38:Agricultural chemistry and related fields
    • Research Institution
      University of Shizuoka
  •  Influence of dietary habits on intestinal environment of mothers and children in Okinawa: Family and community aspects

    • Principal Investigator
      等々力 英美
    • Project Period (FY)
      2021 – 2024
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 08030:Family and consumer sciences, and culture and living-related
    • Research Institution
      University of the Ryukyus
  •  A Randomized Intervention Trial to Promote Healthy Dietary Intake among Parents and Children in Okinawa: Based on Health Checkup Data of Nursery School

    • Principal Investigator
      名嘉地 めぐみ
    • Project Period (FY)
      2021 – 2024
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 09030:Childhood and nursery/pre-school education-related
    • Research Institution
      University of the Ryukyus
  •  Cell therapy by using engineered biosynthesis of anticancer agent in tumor cellsPrincipal Investigator

    • Principal Investigator
      Watanabe Kenji
    • Project Period (FY)
      2019 – 2021
    • Research Category
      Grant-in-Aid for Challenging Research (Exploratory)
    • Review Section
      Medium-sized Section 38:Agricultural chemistry and related fields
    • Research Institution
      University of Shizuoka
  •  Integrating Computational and Experimental Approaches for New Paradigms in Molecule SynthesisPrincipal Investigator

    • Principal Investigator
      Watanabe Kenji
    • Project Period (FY)
      2019 – 2021
    • Research Category
      Fund for the Promotion of Joint International Research (Fostering Joint International Research (B))
    • Review Section
      Medium-sized Section 38:Agricultural chemistry and related fields
    • Research Institution
      University of Shizuoka
  •  Chemical characterization of colibactin and understanding a mechanism of an onset of colorectal cancer by colibactinPrincipal Investigator

    • Principal Investigator
      Watanabe Kenji
    • Project Period (FY)
      2019 – 2021
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Review Section
      Basic Section 38040:Bioorganic chemistry-related
    • Research Institution
      University of Shizuoka
  •  Redesigning Biosynthetic Machineries (Project Team)

    • Principal Investigator
      Abe Ikuro
    • Project Period (FY)
      2016 – 2020
    • Research Category
      Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
    • Review Section
      Science and Engineering
    • Research Institution
      The University of Tokyo
  •  Engineered biosynthesis of new natural products for innovative drug discoveryPrincipal Investigator

    • Principal Investigator
      Watanabe Kenji
    • Project Period (FY)
      2016 – 2020
    • Research Category
      Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
    • Review Section
      Science and Engineering
    • Research Institution
      University of Shizuoka
  •  Profiling analysis of intestinal endotoxins associated with chronic inflammation in lifestyle-related diseases

    • Principal Investigator
      Miyoshi Noriyuki
    • Project Period (FY)
      2016 – 2019
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Eating habits
    • Research Institution
      University of Shizuoka
  •  Redesigning Biosynthetic Machineries (International Activity Support Team)

    • Principal Investigator
      Abe Ikuro
    • Project Period (FY)
      2016 – 2021
    • Research Category
      Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
    • Review Section
      Science and Engineering
    • Research Institution
      The University of Tokyo
  •  Diels-Alder反応を触媒する酵素が持つ遷移状態制御の解明Principal Investigator

    • Principal Investigator
      渡辺 賢二
    • Project Period (FY)
      2015 – 2017
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Transition State Control
    • Research Institution
      University of Shizuoka
  •  Characterization of genotoxins, colibactin, facilitating inflammation-induced colorectal cancerPrincipal Investigator

    • Principal Investigator
      Watanabe Kenji
    • Project Period (FY)
      2014 – 2016
    • Research Category
      Grant-in-Aid for Challenging Exploratory Research
    • Research Field
      Chemical biology
    • Research Institution
      University of Shizuoka
  •  Unprecedented enzyme-catalyzed generation of complexity in fumagillin-pseurotin biosynthesis

    • Principal Investigator
      Noguchi Hiroshi
    • Project Period (FY)
      2014 – 2016
    • Research Category
      Grant-in-Aid for Challenging Exploratory Research
    • Research Field
      Natural medicines
    • Research Institution
      Nihon Pharmaceutical University
      University of Shizuoka
  •  Unification of biosynthetic pathways of a variety of plant polyketides

    • Principal Investigator
      Noguchi Hiroshi
    • Project Period (FY)
      2013 – 2015
    • Research Category
      Grant-in-Aid for Scientific Research (A)
    • Research Field
      Biomolecular chemistry
    • Research Institution
      University of Shizuoka
  •  生合成遺伝子の異種発現によるテトラヒドロイソキノリン類の合成Principal Investigator

    • Principal Investigator
      渡辺 賢二
    • Project Period (FY)
      2011
    • Research Category
      Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
    • Review Section
      Science and Engineering
    • Research Institution
      University of Shizuoka
  •  有用天然物の生合成遺伝子発現によるシンセティックバイオロジーの確立Principal Investigator

    • Principal Investigator
      渡辺 賢二
    • Project Period (FY)
      2011
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Chemical biology
    • Research Institution
      University of Shizuoka
  •  病原性微生物が生産する天然物の化学構造決定および生合成機構の解明に関する研究Principal Investigator

    • Principal Investigator
      渡辺 賢二
    • Project Period (FY)
      2011
    • Research Category
      Grant-in-Aid for Challenging Exploratory Research
    • Research Field
      Chemical biology
    • Research Institution
      University of Shizuoka
  •  Generating molecular diversity by the wide range of polyketide synthases

    • Principal Investigator
      NOGUCHI Hiroshi
    • Project Period (FY)
      2010 – 2012
    • Research Category
      Grant-in-Aid for Scientific Research (A)
    • Research Field
      Living organism molecular science
    • Research Institution
      University of Shizuoka
  •  Reverse genetics and recombination

    • Principal Investigator
      IIDA Shigeru
    • Project Period (FY)
      2010 – 2012
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Genetics/Genome dynamics
    • Research Institution
      University of Shizuoka
  •  Biosynthesis of natural antitumor agents and their rationally engineered analogs in Escherichia coliPrincipal Investigator

    • Principal Investigator
      WATANABE Kenji
    • Project Period (FY)
      2009 – 2010
    • Research Category
      Grant-in-Aid for Young Scientists (B)
    • Research Field
      Bioproduction chemistry/Bioorganic chemistry
    • Research Institution
      University of Shizuoka
  •  セルロース有効利用を目指したセルロース分解酵素クラスターの単離および機能構築Principal Investigator

    • Principal Investigator
      渡辺 賢二
    • Project Period (FY)
      2004
    • Research Category
      Grant-in-Aid for Young Scientists (B)
    • Research Field
      Applied biochemistry
    • Research Institution
      Hokkaido University

All 2024 2023 2022 2021 2020 2019 2018 2017 2016 2015 2013 2012 2011 2010 2009 Other

All Journal Article Presentation Book Patent

  • [Book] Polyketide synthase and nonribosomal peptide synthetase hybrid enzymes of fungi. The Mycota XV: Physiology and Genetics2018

    • Author(s)
      Kishimoto, S., Hirayama, Y., Watanabe, K.
    • Total Pages
      7
    • Publisher
      Springer
    • Data Source
      KAKENHI-PLANNED-16H06449
  • [Book] 天然物の化学Ⅱ(科学のとびら64)2018

    • Author(s)
      上村大輔, 渡辺賢二
    • Total Pages
      192
    • Publisher
      東京化学同人
    • ISBN
      9784807915057
    • Data Source
      KAKENHI-PLANNED-16H06449
  • [Book] 天然物生合成におけるS-アデノシルメチオニン依存性酵素により触媒されるペリ環状反応2018

    • Author(s)
      大橋雅生, 渡辺賢二
    • Total Pages
      6
    • Publisher
      現代化学
    • Data Source
      KAKENHI-PLANNED-16H06449
  • [Book] 現代化学2017

    • Author(s)
      大橋雅生, 渡辺賢二
    • Total Pages
      6
    • Publisher
      東京化学同人
    • Data Source
      KAKENHI-PLANNED-16H06449
  • [Book] BIO Clinica2017

    • Author(s)
      渡辺賢二
    • Total Pages
      4
    • Publisher
      北隆館/ニュー・サイエンス社
    • Data Source
      KAKENHI-PLANNED-16H06449
  • [Book] Complex enzymes : overview and peptides(Assembling nonribosomal peptide gene cluster in a heterologous host.)(edited by David Hopwood.)2009

    • Author(s)
      Watanabe, K., Praseuth, A.P., Praseuth, M.B., Hotta, K.
    • Publisher
      Methods in Enzymology
    • Data Source
      KAKENHI-PROJECT-21780106
  • [Book] 天然物全合成の最新動向(生合成酵素による天然物の全合成-抗腫瘍性物質エキノマイシンの合成を中心に-)(北泰行監修)2009

    • Author(s)
      渡辺賢二, 大栗博毅, 及川英秋
    • Publisher
      シーエムシー出版
    • Data Source
      KAKENHI-PROJECT-21780106
  • [Journal Article] Reactive Azlactone Intermediate Drives Fungal Secondary Metabolite Cross-Pathway Generation2023

    • Author(s)
      Kishimoto Shinji、Minami Ayumi、Aoki Yoshimitsu、Matsubara Yuya、Watanabe Shogo、Watanabe Kenji
    • Journal Title

      Journal of the American Chemical Society

      Volume: 145 Issue: 5 Pages: 3221-3228

    • DOI

      10.1021/jacs.2c13188

    • Peer Reviewed / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-21K14795, KAKENHI-PROJECT-22H04922, KAKENHI-PLANNED-22H05121, KAKENHI-PROJECT-22H04979
  • [Journal Article] Association between physical activity and the prevalence of tumorigenic bacteria in the gut microbiota of Japanese adults: a cross-sectional study2023

    • Author(s)
      Iwasaka Chiharu、Ninomiya Yuka、Nakagata Takashi、Nanri Hinako、Watanabe Daiki、Ohno Harumi、Tanisawa Kumpei、Konishi Kana、Murakami Haruka、Tsunematsu Yuta、Sato Michio、Watanabe Kenji、Miyachi Motohiko
    • Journal Title

      Scientific Reports

      Volume: 13 Issue: 1 Pages: 20841-20841

    • DOI

      10.1038/s41598-023-47442-9

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-21K17284, KAKENHI-PROJECT-22K17838, KAKENHI-PROJECT-22K06665, KAKENHI-ORGANIZER-23H03820, KAKENHI-PLANNED-23H03823, KAKENHI-PROJECT-22H04979, KAKENHI-PROJECT-23K27966
  • [Journal Article] Biosynthetic Gene Expression and Tissue Distribution of Diosgenin in Dioscorea japonica2023

    • Author(s)
      Onoda Keita、Kato Mai、Tsunematsu Yuta、Eto Fumihiro、Sato Michio、Yoshioka Yasukiyo、Yoshida Takuya、Tamura Kentaro、Yao Ikuko、Dohra Hideo、Watanabe Kenji、Miyoshi Noriyuki
    • Journal Title

      Journal of Agricultural and Food Chemistry

      Volume: 71 Issue: 10 Pages: 4292-4297

    • DOI

      10.1021/acs.jafc.2c08478

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22K06269, KAKENHI-PROJECT-22K06665, KAKENHI-PROJECT-22K11757, KAKENHI-PLANNED-22H05121, KAKENHI-PROJECT-20K05866, KAKENHI-PROJECT-20H04109
  • [Journal Article] Screening method toward ClbP-specific inhibitors2023

    • Author(s)
      Zhou, T., Ando, T., Kudo, A., Sato, M., Miyoshi, N., Mutoh, M., Ishikawa, H., Wakabayashi, K., Watanabe, K.
    • Journal Title

      Genes and Environment

      Volume: 45 Issue: 1 Pages: 8-8

    • DOI

      10.1186/s41021-023-00264-7

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-22K06665, KAKENHI-PROJECT-22H04979
  • [Journal Article] 抗生物質生産菌が持つ自己耐性酵素の機能解明2023

    • Author(s)
      佐藤道大、渡辺賢二
    • Journal Title

      酵素工学研究会誌

      Volume: 89 Pages: 27-30

    • Peer Reviewed
    • Data Source
      KAKENHI-PLANNED-22H05121
  • [Journal Article] Uncommon arrangement of self-resistance allows biosynthesis of de novo purine biosynthesis inhibitor that acts as immunosuppressor2023

    • Author(s)
      Sato, M., Sakano, S., Nakahara, M., Tamura, Y., Hara, K., Hashimoto, H., Tang, Y., Watanabe, K.
    • Journal Title

      J. Am. Chem. Soc.

      Volume: 145 Issue: 49 Pages: 26883-26889

    • DOI

      10.1021/jacs.3c09600

    • Peer Reviewed / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-22K06665, KAKENHI-PROJECT-23K05669, KAKENHI-PLANNED-22H05121, KAKENHI-PROJECT-22H04979, KAKENHI-PROJECT-20H03197
  • [Journal Article] Biosynthesis of polycyclic natural products from conjugated polyenes via tandem isomerization and pericyclic reactions2023

    • Author(s)
      Niwa, K., Ohashi, M., Xie, K., Chiang, C. Y., Jamieson, C. S., Sato, M., Watanabe, K., Liu, F., Houk, K. N., Tang, Y.
    • Journal Title

      J. Am. Chem. Soc.

      Volume: 145 Issue: 25 Pages: 13520-13525

    • DOI

      10.1021/jacs.3c02380

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-22K06665, KAKENHI-PLANNED-22H05121, KAKENHI-PROJECT-22H04979
  • [Journal Article] Non-target GC-MS analyses of fecal VOCs in NASH-hepatocellular carcinoma model STAM mice2023

    • Author(s)
      Kato Mai、Yamaguchi Momoka、Ooka Akira、Takahashi Ryota、Suzuki Takuji、Onoda Keita、Yoshikawa Yuko、Tsunematsu Yuta、Sato Michio、Yoshioka Yasukiyo、Igarashi Miki、Hayakawa Sumio、Shoji Kumiko、Shoji Yutaka、Ishikawa Tomohisa、Watanabe Kenji、Miyoshi Noriyuki
    • Journal Title

      Scientific Reports

      Volume: 13 Issue: 1 Pages: 8924-8924

    • DOI

      10.1038/s41598-023-36091-7

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-22K17781, KAKENHI-PROJECT-22K06665, KAKENHI-PROJECT-22K07078, KAKENHI-PROJECT-22K11757, KAKENHI-PROJECT-21K19727, KAKENHI-ORGANIZER-23H03820, KAKENHI-PLANNED-23H03823, KAKENHI-PROJECT-22H04979, KAKENHI-PROJECT-20H04109, KAKENHI-PROJECT-23K28004
  • [Journal Article] 大腸菌が産生する発がんリスク因子「コリバクチン」の化学構造の全容解明2022

    • Author(s)
      平山 裕一郎、渡辺 賢二
    • Journal Title

      化学と生物

      Volume: 3 Pages: 123-130

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19H02898
  • [Journal Article] Novel Gene Therapy by Expression of Biosynthetic Function2022

    • Author(s)
      Matsuda Shinya、Watanabe Kenji
    • Journal Title

      Journal of Synthetic Organic Chemistry, Japan

      Volume: 80 Issue: 8 Pages: 747-754

    • DOI

      10.5059/yukigoseikyokaishi.80.747

    • ISSN
      0037-9980, 1883-6526
    • Year and Date
      2022-08-01
    • Language
      Japanese
    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22K19158
  • [Journal Article] Cytotoxic Homo- and Hetero-Dimers of o-toluidine, o-anisidine, and Aniline Formed by In Vitro Metabolism2022

    • Author(s)
      Kobayashi Takuma、Kishimoto Shinji、Watanabe Shogo、Yoshioka Yasukiyo、Toyoda Takeshi、Ogawa Kumiko、Watanabe Kenji、Totsuka Yukari、Wakabayashi Keiji、Miyoshi Noriyuki
    • Journal Title

      Chemical Research in Toxicology

      Volume: 35 Issue: 9 Pages: 1625-1630

    • DOI

      10.1021/acs.chemrestox.2c00226

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22K11757, KAKENHI-PROJECT-22H04979
  • [Journal Article] Advancing the Biosynthetic and Chemical Understanding of the Carcinogenic Risk Factor Colibactin and Its Producers2022

    • Author(s)
      Hirayama Yuichiro、Sato Michio、Watanabe Kenji
    • Journal Title

      Biochemistry

      Volume: 61 Issue: 24 Pages: 2782-2790

    • DOI

      10.1021/acs.biochem.2c00229

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22K06665, KAKENHI-PROJECT-22H04979
  • [Journal Article] Toward Engineered Biosynthesis of Drugs in Human Cells2021

    • Author(s)
      Matsuda Shinya、Tsunematsu Yuta、Matsushita Takuma、Ogata Yuji、Hachiya Shihomi、Kishimoto Shinji、Miyoshi Noriyuki、Watanabe Kenji
    • Journal Title

      ChemBioChem

      Volume: 23 Issue: 4 Pages: 1-7

    • DOI

      10.1002/cbic.202100645

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19K22291, KAKENHI-PROJECT-20K05866
  • [Journal Article] Catalytic mechanism and endo-to-exo selectivity reversion of an octalin-forming natural Diels?Alderase2021

    • Author(s)
      Sato Michio、Kishimoto Shinji、Yokoyama Mamoru、Jamieson Cooper S.、Narita Kazuto、Maeda Naoya、Hara Kodai、Hashimoto Hiroshi、Tsunematsu Yuta、Houk Kendall N.、Tang Yi、Watanabe Kenji
    • Journal Title

      Nature Catalysis

      Volume: 4 Issue: 3 Pages: 223-232

    • DOI

      10.1038/s41929-021-00577-2

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-20K05866, KAKENHI-PLANNED-16H06449, KAKENHI-PROJECT-20H03197, KAKENHI-PROJECT-17K07314, KAKENHI-PROJECT-19K07136, KAKENHI-PROJECT-19KK0150
  • [Journal Article] ディールス-アルダラーゼとはどういった酵素なのか2021

    • Author(s)
      佐藤道大, 渡辺賢二
    • Journal Title

      化学

      Volume: 2 Pages: 72-73

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19KK0150
  • [Journal Article] Isolation of New Colibactin Metabolites from Wild-Type Escherichia coli and In Situ Trapping of a Mature Colibactin Derivative2021

    • Author(s)
      Tao Zhou, Yuichiro Hirayama, Yuta Tsunematsu, Nanami Suzuki, Seiji Tanaka, Nahoko Uchiyama, Yukihiro Goda, Yuko Yoshikawa, Yuji Iwashita, Michio Sato, Noriyuki Miyoshi, Michihiro Mutoh, Hideki Ishikawa, Haruhiko Sugimura, Keiji Wakabayashi, and Kenji Watanabe*
    • Journal Title

      JACS

      Volume: 1 Pages: 1-8

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19H02898
  • [Journal Article] Discovery and investigation of natural Diels?Alderases2021

    • Author(s)
      Watanabe Kenji
    • Journal Title

      Journal of Natural Medicines

      Volume: 1 Issue: 3 Pages: 1-6

    • DOI

      10.1007/s11418-021-01502-4

    • NAID

      40022591483

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-19KK0150
  • [Journal Article] o-Anisidine Dimer, 2-Methoxy-N4-(2-methoxyphenyl) Benzene-1,4-diamine, in Rat Urine Associated with Urinary bladder Carcinogenesis2021

    • Author(s)
      Kobayashi Takuma、Toyoda Takeshi、Tajima Yuya、Kishimoto Shinji、Tsunematsu Yuta、Sato Michio、Matsushita Kohei、Yamada Takanori、Shimamura Yuko、Masuda Shuichi、Ochiai Masako、Ogawa Kumiko、Watanabe Kenji、Takamura-Enya Takeji、Totsuka Yukari、Wakabayashi Keiji、Miyoshi Noriyuki
    • Journal Title

      Chemical Research in Toxicology

      Volume: 34 Issue: 3 Pages: 912-919

    • DOI

      10.1021/acs.chemrestox.0c00536

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19K07136, KAKENHI-PROJECT-20K05866, KAKENHI-PROJECT-20K10452, KAKENHI-PROJECT-19H02898, KAKENHI-PROJECT-19K12344, KAKENHI-PROJECT-20H04109
  • [Journal Article] Isolation of New Colibactin Metabolites from Wild-Type Escherichia coli and In Situ Trapping of a Mature Colibactin Derivative2021

    • Author(s)
      Zhou Tao、Hirayama Yuichiro、Tsunematsu Yuta、Suzuki Nanami、Tanaka Seiji、Uchiyama Nahoko、Goda Yukihiro、Yoshikawa Yuko、Iwashita Yuji、Sato Michio、Miyoshi Noriyuki、Mutoh Michihiro、Ishikawa Hideki、Sugimura Haruhiko、Wakabayashi Keiji、Watanabe Kenji
    • Journal Title

      Journal of the American Chemical Society

      Volume: 143 Issue: 14 Pages: 5526-5533

    • DOI

      10.1021/jacs.1c01495

    • Peer Reviewed / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-20K05866, KAKENHI-PROJECT-19K07136, KAKENHI-PROJECT-19H02898
  • [Journal Article] Elevated levels of proinflammatory volatile metabolites in feces of high fat diet fed KK-Ay mice2020

    • Author(s)
      Uchikawa Misaki、Kato Mai、Nagata Akika、Sanada Shunsuke、Yoshikawa Yuto、Tsunematsu Yuta、Sato Michio、Suzuki Takuji、Hashidume Tsutomu、Watanabe Kenji、Yoshikawa Yuko、Miyoshi Noriyuki
    • Journal Title

      Scientific Reports

      Volume: 10 Issue: 1 Pages: 5681-5681

    • DOI

      10.1038/s41598-020-62541-7

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-16H03041, KAKENHI-PROJECT-18K11123, KAKENHI-PROJECT-19K07136, KAKENHI-PROJECT-20K05866, KAKENHI-PROJECT-17K08841
  • [Journal Article] ディールス-アルダラーゼとはどういった酵素なのか?2020

    • Author(s)
      佐藤道大、渡辺賢二
    • Journal Title

      化学

      Volume: 76 Pages: 72-73

    • Data Source
      KAKENHI-PROJECT-19KK0150
  • [Journal Article] Genotyping of a gene cluster for production of colibactin and in vitro genotoxicity analysis of Escherichia coli strains obtained from the Japan Collection of Microorganisms2020

    • Author(s)
      Kawanishi Masanobu、Shimohara Chiaki、Oda Yoshimitsu、Hisatomi Yuuta、Tsunematsu Yuta、Sato Michio、Hirayama Yuichiro、Miyoshi Noriyuki、Iwashita Yuji、Yoshikawa Yuko、Sugimura Haruhiko、Mutoh Michihiro、Ishikawa Hideki、Wakabayashi Keiji、Yagi Takashi、Watanabe Kenji
    • Journal Title

      Genes and Environment

      Volume: 42 Issue: 1 Pages: 12-17

    • DOI

      10.1186/s41021-020-00149-z

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-18J02190, KAKENHI-PROJECT-19K07136, KAKENHI-PROJECT-20K05866, KAKENHI-PROJECT-19H02898, KAKENHI-PROJECT-17K08841
  • [Journal Article] Artesunate Inhibits Intestinal Tumorigenesis through Inhibiting Wnt Signaling.2020

    • Author(s)
      Hamoya T, Fujii G, Iizumi Y, Narita T, Komiya M, Matsuzawa Y, Miki K, Kondo T, Kishimoto S, Watanabe K, Wakabayashi K, Sakai T, Toshima J, Mutoh M
    • Journal Title

      Carcinogenesis

      Volume: 42 Issue: 1 Pages: 148-58

    • DOI

      10.1093/carcin/bgaa084

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-18K11066, KAKENHI-PROJECT-19K06571, KAKENHI-ORGANIZER-17H06391, KAKENHI-PLANNED-17H06398, KAKENHI-PROJECT-19H01079, KAKENHI-PROJECT-19H02898, KAKENHI-PROJECT-19J10184
  • [Journal Article] A new class of dimeric product isolated from the fungus Chaetomium globosum: evaluation of chemical structure and biological activity2020

    • Author(s)
      Sarmales-Murga Christopher、Akaoka Fumito、Sato Michio、Takanishi Jun、Mino Takashi、Miyoshi Noriyuki、Watanabe Kenji
    • Journal Title

      The Journal of Antibiotics

      Volume: 73 Issue: 5 Pages: 320-323

    • DOI

      10.1038/s41429-020-0281-x

    • Peer Reviewed
    • Data Source
      KAKENHI-PLANNED-16H06449, KAKENHI-PROJECT-19K07136
  • [Journal Article] Biosynthesis of the Immunosuppressant (?)-FR9014832020

    • Author(s)
      Zhang Zhuan、Tamura Yui、Tang Mancheng、Qiao Tianzhang、Sato Michio、Otsu Yoshihiro、Sasamura Satoshi、Taniguchi Masatoshi、Watanabe Kenji、Tang Yi
    • Journal Title

      Journal of the American Chemical Society

      Volume: 143 Issue: 1 Pages: 132-136

    • DOI

      10.1021/jacs.0c12352

    • Peer Reviewed / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-19K07136, KAKENHI-PROJECT-19KK0150, KAKENHI-PLANNED-16H06449
  • [Journal Article] Oxidative modification enzymes in polyketide biosynthetic pathways2020

    • Author(s)
      Tsunematsu, Y., Hirayama, Y., Masuya, T., Watanabe, K.
    • Journal Title

      Comprehensive Natural Products III: Chemistry and Biology, Wiley

      Volume: 4 Pages: 30-30

    • Peer Reviewed
    • Data Source
      KAKENHI-PLANNED-16H06449
  • [Journal Article] Concise Biosynthesis of Phenylfuropyridones in Fungi2020

    • Author(s)
      Zhang Zhuan、Qiao Tianzhang、Watanabe Kenji、Tang Yi
    • Journal Title

      Angewandte Chemie International Edition

      Volume: 59 Issue: 45 Pages: 19889-19893

    • DOI

      10.1002/anie.202008321

    • Peer Reviewed / Int'l Joint Research
    • Data Source
      KAKENHI-PLANNED-16H06449
  • [Journal Article] Specialized Flavoprotein Promotes Sulfur Migration and Spiroaminal Formation in Aspirochlorine Biosynthesis2020

    • Author(s)
      Tsunematsu Yuta、Maeda Naoya、Sato Michio、Hara Kodai、Hashimoto Hiroshi、Watanabe Kenji、Hertweck Christian
    • Journal Title

      Journal of the American Chemical Society

      Volume: 143 Issue: 1 Pages: 206-213

    • DOI

      10.1021/jacs.0c08879

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-19K07136, KAKENHI-PROJECT-20K05866, KAKENHI-PROJECT-19KK0150, KAKENHI-PLANNED-16H06449, KAKENHI-PROJECT-20H03197, KAKENHI-PROJECT-17K07314
  • [Journal Article] Bisindole2020

    • Author(s)
      Sato, M., Kishimoto, S., Noguchi, H., Watanabe, K.
    • Journal Title

      Comprehensive Natural Products III: Chemistry and Biology, Wiley

      Volume: 4 Pages: 1-1

    • Peer Reviewed
    • Data Source
      KAKENHI-PLANNED-16H06449
  • [Journal Article] Uncovering hidden sesquiterpene biosynthetic pathway through expression boost area-mediated productivity enhancement in basidiomycete2020

    • Author(s)
      Asai Shihori、Tsunematsu Yuta、Masuya Takahiro、Otaka Junnosuke、Osada Hiroyuki、Watanabe Kenji
    • Journal Title

      The Journal of Antibiotics

      Volume: 73 Issue: 10 Pages: 721-728

    • DOI

      10.1038/s41429-020-0355-9

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20K05866, KAKENHI-PROJECT-20K15457, KAKENHI-PLANNED-16H06449, KAKENHI-PLANNED-17H06412, KAKENHI-PROJECT-18H03945
  • [Journal Article] Biosynthesis of lagopodins in mushroom involves a complex network of oxidation reactions2019

    • Author(s)
      Masuya Takahiro、Tsunematsu Yuta、Hirayama Yuichiro、Sato Michio、Noguchi Hiroshi、Nakazawa Takehito、Watanabe Kenji
    • Journal Title

      Organic & Biomolecular Chemistry

      Volume: 17 Issue: 2 Pages: 234-239

    • DOI

      10.1039/c8ob02814a

    • Peer Reviewed
    • Data Source
      KAKENHI-PLANNED-16H06449, KAKENHI-PROJECT-16H05840, KAKENHI-PROJECT-17H07002, KAKENHI-PROJECT-17K15265
  • [Journal Article] <i>In vitro</i> genotoxicity analyses of colibactin-producing <i>E. coli</i> isolated from a Japanese colorectal cancer patient2019

    • Author(s)
      Kawanishi Masanobu、Hisatomi Yuuta、Oda Yoshimitsu、Shimohara Chiaki、Tsunematsu Yuta、Sato Michio、Hirayama Yuichiro、Miyoshi Noriyuki、Iwashita Yuji、Yoshikawa Yuko、Sugimura Haruhiko、Mutoh Michihiro、Ishikawa Hideki、Wakabayashi Keiji、Yagi Takashi、Watanabe Kenji
    • Journal Title

      The Journal of Toxicological Sciences

      Volume: 44 Issue: 12 Pages: 871-876

    • DOI

      10.2131/jts.44.871

    • NAID

      130007759775

    • ISSN
      0388-1350, 1880-3989
    • Language
      English
    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-17K08841, KAKENHI-PROJECT-19H02898, KAKENHI-PROJECT-18J02190
  • [Journal Article] Activity-Based Probe for Screening of High-Colibactin Producers from Clinical Samples2019

    • Author(s)
      Hirayama Yuichiro、Tsunematsu Yuta、Yoshikawa Yuko、Tamafune Ryota、Matsuzaki Nobuo、Iwashita Yuji、Ohnishi Ippei、Tanioka Fumihiko、Sato Michio、Miyoshi Noriyuki、Mutoh Michihiro、Ishikawa Hideki、Sugimura Haruhiko、Wakabayashi Keiji、Watanabe Kenji
    • Journal Title

      Organic Letters

      Volume: 21 Issue: 12 Pages: 4490-4494

    • DOI

      10.1021/acs.orglett.9b01345

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17K08841, KAKENHI-PROJECT-19H02898, KAKENHI-PROJECT-18J02190
  • [Journal Article] Genomic Mushroom Hunting Decrypts Coprinoferrin, A Siderophore Secondary Metabolite Vital to Fungal Cell Development2019

    • Author(s)
      Tsunematsu Yuta、Takanishi Jun、Asai Shihori、Masuya Takahiro、Nakazawa Takehito、Watanabe Kenji
    • Journal Title

      Organic Letters

      Volume: 21 Issue: 18 Pages: 7582-7586

    • DOI

      10.1021/acs.orglett.9b02861

    • NAID

      40022757906

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19KK0150, KAKENHI-PLANNED-16H06449
  • [Journal Article] Functional and Structural Analyses of trans C-Methyltransferase in Fungal Polyketide Biosynthesis2019

    • Author(s)
      Kishimoto Shinji、Tsunematsu Yuta、Matsushita Takuma、Hara Kodai、Hashimoto Hiroshi、Tang Yi、Watanabe Kenji
    • Journal Title

      Biochemistry

      Volume: 58 Issue: 38 Pages: 3933-3937

    • DOI

      10.1021/acs.biochem.9b00702

    • Peer Reviewed / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-17K07314, KAKENHI-PROJECT-19K15757, KAKENHI-PROJECT-19KK0150, KAKENHI-PLANNED-16H06449, KAKENHI-PROJECT-16H05840
  • [Journal Article] Polyketide synthase-nonribosomal peptide synthetase hybrid enzymes of fungi2018

    • Author(s)
      Kishimoto, S., Hirayama, Y., Watanabe, K.
    • Journal Title

      The Mycota XV: Physiology and Genetics

      Volume: 368 Pages: 1-1

    • Peer Reviewed
    • Data Source
      KAKENHI-PLANNED-16H06449
  • [Journal Article] Genome Mining and Assembly-Line Biosynthesis of the UCS1025A Pyrrolizidinone Family of Fungal Alkaloids2018

    • Author(s)
      Li Li、Tang Man-Cheng、Tang Shoubin、Gao Shushan、Soliman Sameh、Hang Leibniz、Xu Wei、Ye Tao、Watanabe Kenji、Tang Yi
    • Journal Title

      Journal of the American Chemical Society

      Volume: 140 Issue: 6 Pages: 2067-2071

    • DOI

      10.1021/jacs.8b00056

    • Peer Reviewed / Int'l Joint Research
    • Data Source
      KAKENHI-PLANNED-16H06449
  • [Journal Article] Enzymatic Amide Tailoring Promotes Retro-Aldol Amino Acid Conversion To Form the Antifungal Agent Aspirochlorine2018

    • Author(s)
      Tsunematsu Yuta、Maeda Naoya、Yokoyama Mamoru、Chankhamjon Pranatchareeya、Watanabe Kenji、Scherlach Kirstin、Hertweck Christian
    • Journal Title

      Angewandte Chemie International Edition

      Volume: 57 Issue: 43 Pages: 14051-14054

    • DOI

      10.1002/anie.201806740

    • Peer Reviewed / Int'l Joint Research
    • Data Source
      KAKENHI-PLANNED-16H06449, KAKENHI-PROJECT-17K15265
  • [Journal Article] Enzymatic one-step ring contraction for quinolone biosynthesis2018

    • Author(s)
      Kishimoto Shinji、Hara Kodai、Hashimoto Hiroshi、Hirayama Yuichiro、Champagne Pier Alexandre、Houk Kendall N.、Tang Yi、Watanabe Kenji
    • Journal Title

      Nature Communications

      Volume: 9 Issue: 1 Pages: 2826-2826

    • DOI

      10.1038/s41467-018-05221-5

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-17K07314, KAKENHI-PLANNED-16H06449, KAKENHI-PUBLICLY-17H06014, KAKENHI-PROJECT-16H04755, KAKENHI-PROJECT-16H05113, KAKENHI-PROJECT-16H05840
  • [Journal Article] Integration of chemical, genetic and bioinformatic approaches delineates fungal polyketide-peptide hybrid biosynthesis.2017

    • Author(s)
      Yokoyama, M., Hirayama, Y., Yamamoto, T., Kishimoto, S., Tsunematsu, Y., Watanabe, K.
    • Journal Title

      Org. Lett.

      Volume: 印刷中 Issue: 8 Pages: 2002-2005

    • DOI

      10.1021/acs.orglett.7b00559

    • Peer Reviewed / Acknowledgement Compliant / Open Access
    • Data Source
      KAKENHI-PLANNED-16H06449
  • [Journal Article] Elucidation of biosynthetic pathways of natural products.2017

    • Author(s)
      Kishimoto, S., Tsunematsu, Y., Sato, M., Watanabe, K.
    • Journal Title

      The Chemical Record

      Volume: 印刷中 Issue: 11 Pages: 1095-1108

    • DOI

      10.1002/tcr.201700015

    • Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PLANNED-16H06449, KAKENHI-PROJECT-15KT0068, KAKENHI-PROJECT-17K15265
  • [Journal Article] Oxidative Cyclization in Natural Product Biosynthesis2017

    • Author(s)
      Tang Man-Cheng、Zou Yi、Watanabe Kenji、Walsh Christopher T.、Tang Yi
    • Journal Title

      Chemical Reviews

      Volume: 117 Issue: 8 Pages: 5226-5333

    • DOI

      10.1021/acs.chemrev.6b00478

    • Peer Reviewed / Int'l Joint Research
    • Data Source
      KAKENHI-PLANNED-16H06449
  • [Journal Article] Collaborative biosynthesis of maleimide- and succinimide- containing natural products by fungal polyketide megasynthases.2017

    • Author(s)
      Sato, M., Dander, J. E., Sato, C., Hung, Y.-S., Gao, S.-S., Tang, M.-C., Hang, L., Winter, J. M., Garg, N. K.*, Watanabe, K.*, Tang, Y.*
    • Journal Title

      J. Am. Chem. Soc.

      Volume: 印刷中 Issue: 15 Pages: 5317-5320

    • DOI

      10.1021/jacs.7b02432

    • Peer Reviewed / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-15KT0068
  • [Journal Article] SAM-dependent enzyme-catalysed pericyclic reactions in natural product biosynthesis2017

    • Author(s)
      1.Ohashi, M., Liu, F., Hai, Y., Chen, M., Tang, M.-C., Yang, Z., Sato, M., Watanabe, K., Houk, K. N., Tang, Y.
    • Journal Title

      Nature

      Volume: 549 Issue: 7673 Pages: 502-506

    • DOI

      10.1038/nature23882

    • Peer Reviewed / Int'l Joint Research
    • Data Source
      KAKENHI-PLANNED-16H06449
  • [Journal Article] Integration of Chemical, Genetic, and Bioinformatic Approaches Delineates Fungal Polyketide-Peptide Hybrid Biosynthesis2017

    • Author(s)
      Yokoyama M, Hirayama Y, Yamamoto T, Kishimoto S, Tsunematsu Y, Watanabe K
    • Journal Title

      Org Lett

      Volume: 19 Pages: 2002-2005

    • Peer Reviewed / Int'l Joint Research
    • Data Source
      KAKENHI-PLANNED-16H06449
  • [Journal Article] Biochemical characterization of an eukaryotic decalin-forming Diels-Alderase.2016

    • Author(s)
      Li, L., Yu, P., Tang, M. C., Zou, Y., Gao, S.-S., Hung, Y.-S., Zhao, M., Watanabe, K., Houk, K., Tang, Y.
    • Journal Title

      J. Am. Chem. Soc.

      Volume: 138 Issue: 49 Pages: 15837-15840

    • DOI

      10.1021/jacs.6b10452

    • Peer Reviewed / Int'l Joint Research
    • Data Source
      KAKENHI-PLANNED-16H06449, KAKENHI-PROJECT-15KT0068
  • [Journal Article] Oxidative trans to cis Isomerization of Olefins in Polyketide Biosynthesis2016

    • Author(s)
      Tsuyoshi Yamamoto, Yuta Tsunematsu, Kodai Hara, Tomohiro Suzuki, Shinji Kishimoto, Hirokazu Kawaguchi, Hiroshi Noguchi, Hiroshi Hashimoto, Yi Tang, Kinya Hotta, & Kenji Watanabe
    • Journal Title

      Angew Chem Int Ed Engl

      Volume: 印刷中 Issue: 21 Pages: 6207-6210

    • DOI

      10.1002/anie.201600940

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-25291017, KAKENHI-PLANNED-16H06449, KAKENHI-PROJECT-16H05840, KAKENHI-PROJECT-15K18491, KAKENHI-PROJECT-16K00397, KAKENHI-PROJECT-16H04755
  • [Journal Article] Oxidative trans-to-cis isomerization of olefin in polyketide biosynthesis.2016

    • Author(s)
      Yamamoto, T., Tsunematsu, Y., Hara, K., Suzuki, T., Kishimoto, S., Kawagishi, H., Noguchi, H., Hashimoto, H., Tang, Y., Hotta, K., Watanabe, K.
    • Journal Title

      Angew. Chem. Int. Ed.

      Volume: 55

    • Peer Reviewed / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-15KT0068
  • [Journal Article] Regioselective dichlorination of a non-activated aliphatic carbon and phenol bismethylation by a multifunctional fungal flavoenzyme.2016

    • Author(s)
      Chankhamjon, P., Tsunematsu, Y., Ishida-Ito, M., Sasa, Y., Meyer, F., Boettger-Schmidt, D., Urbansky, B., Menzel, K. D., Scherlach, K., Watanabe, K., Hertweck, C.
    • Journal Title

      Angew. Chem. Int. Ed.

      Volume: 55 Issue: 39 Pages: 11955-11959

    • DOI

      10.1002/anie.201604516

    • Peer Reviewed / Int'l Joint Research
    • Data Source
      KAKENHI-PLANNED-16H06449
  • [Journal Article] Activation of transient receptor potential ankyrin 1 by quercetin and its analogs.2016

    • Author(s)
      Toshiyuki Nakamura, Noriyuki Miyoshi, Takeshi Ishii, Miyu Nishikawa, Shinichi Ikushiro, Tatsuo Watanabe
    • Journal Title

      Bioscience, Biotechnology, and Biochemistry

      Volume: 80 Issue: 5 Pages: 949-954

    • DOI

      10.1080/09168451.2015.1132148

    • Peer Reviewed / Acknowledgement Compliant
    • Data Source
      KAKENHI-PROJECT-15K16212, KAKENHI-PROJECT-24300252, KAKENHI-PROJECT-26292072, KAKENHI-PROJECT-16H03041, KAKENHI-PROJECT-16K12726
  • [Journal Article] Combinatorial Generation of Chemical Diversity by Redox Enzymes in Chaetoviridin Biosynthesis2016

    • Author(s)
      Sato M, Winter JM, Kishimoto S, Noguchi H, Tang Yi, Watanabe K
    • Journal Title

      Org. Lettr

      Volume: 18 Issue: 6 Pages: 1446-1449

    • DOI

      10.1021/acs.orglett.6b00380

    • Peer Reviewed / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-16H05840, KAKENHI-PROJECT-15KT0068
  • [Journal Article] Elucidation of Pyranonigrin Biosynthetic Pathway Reveals a Mode of Tetramic Acid, Fused γ-Pyrone, and exo-Methylene Formation.2015

    • Author(s)
      Yamamoto, T., Tsunematsu, Y., Noguchi, H., Hotta, K., Watanabe, K.
    • Journal Title

      Org. Lett.

      Volume: 17 Issue: 20 Pages: 4992-4995

    • DOI

      10.1021/acs.orglett.5b02435

    • Peer Reviewed / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-15KT0068
  • [Journal Article] Elucidation of shanorellin biosynthetic pathway and functional analysis of associated enzymes.2015

    • Author(s)
      Sato, M., Yamada, H., Hotta, K., Watanabe, K.
    • Journal Title

      MedChemComm

      Volume: 6 Issue: 3 Pages: 425-430

    • DOI

      10.1039/c4md00352g

    • Peer Reviewed / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-26670048
  • [Journal Article] Tandem prenyltransferases catalyze isoprenoid elongation and complexity generation in biosynthesis of quinolone alkaloids.2015

    • Author(s)
      Zou, Y., Zhan, Z., Li, D., Tang, M., Watanabe, K., Tang, Y.
    • Journal Title

      J. Am. Chem. Soc.

      Volume: 137 Issue: 15 Pages: 4980-4983

    • DOI

      10.1021/jacs.5b03022

    • Peer Reviewed / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-26560450
  • [Journal Article] Biochemical and structural basis for controlling chemical modularity in fungal polyketide biosynthesis.2015

    • Author(s)
      Winter, J. M., Cascio, D., Dietrich, D., Sato, M., Watanabe, K., Sawaya, M., Vederas, J. C., Tang, Y.
    • Journal Title

      J. Am. Chem. Soc.

      Volume: 137 Issue: 31 Pages: 9885-9893

    • DOI

      10.1021/jacs.5b04520

    • Peer Reviewed / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-26560450
  • [Journal Article] Combinatorial generation of complexity by redox enzymes in the chaetoglobosin a biosynthesis2013

    • Author(s)
      K. Ishiuchi, T. Nakazawa, F. Yagishita, T. Mino, H. Noguchi, K. Hotta, K. Watanabe
    • Journal Title

      J. Am. Chem. Soc

      Volume: 135 Pages: 7371-7377

    • Data Source
      KAKENHI-PROJECT-22241054
  • [Journal Article] Targeted disruption of transcriptional regulators in Chaetomium globosum activates biosynthetic pathways and reveals transcriptional regulator-like behavior of aureonitol.2013

    • Author(s)
      Nakazawa T, et al.
    • Journal Title

      J. Am. Chem. Soc

      Volume: 135 Issue: 36 Pages: 13446-13455

    • DOI

      10.1021/ja405128k

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23406031, KAKENHI-PROJECT-25242067
  • [Journal Article] Combinatorial Generation of Complexity by Redox Enzymes in the Chaetoglobosin A Biosynthesis2013

    • Author(s)
      K. Ishiuchi, T. Nakazawa, F. Yagishita, T. Mino, H. Noguchi, K.a Hotta, K. Watanabe
    • Journal Title

      J. Am. Chem. Soc.

      Volume: 135 Issue: 19 Pages: 7371-7377

    • DOI

      10.1021/ja402828w

    • URL

      http://dx.doi.org/

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22241054, KAKENHI-PROJECT-23406031, KAKENHI-PROJECT-23880025, KAKENHI-PROJECT-25242067
  • [Journal Article] Spiro-carbon formation by different chemistry involving pathway crosstalk.2013

    • Author(s)
      石川格靖, 他8名
    • Journal Title

      Nature Chemical Biology

      Volume: 9 Issue: 12 Pages: 818-825

    • DOI

      10.1038/nchembio.1366

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-13J10688, KAKENHI-PROJECT-23310140, KAKENHI-PROJECT-23406031, KAKENHI-PUBLICLY-25108717, KAKENHI-PROJECT-25242067, KAKENHI-PROJECT-25640115
  • [Journal Article] Establishing a new methodology for genome mining and biosynthesis of polyketides and peptides through yeast molecular genetics2012

    • Author(s)
      K. Ishiuchi, T. Nakazawa, T. Ookuma, S. Sugimoto, M. Sato, Y. Tsunematsu, N. Ishikawa, H. Noguchi, K. Hotta, H. Moriya, K. Watanabe
    • Journal Title

      ChemBioChem

      Volume: 13(6) Pages: 846-854

    • Data Source
      KAKENHI-PROJECT-22241054
  • [Journal Article] Overexpressing transcriptional regulator in Aspergillus oryzae activates a silent biosynthetic pathway to produce novel polyketide2012

    • Author(s)
      T. Nakazawa, K. Ishiuchi, A. Praseuth, H. Noguchi, K. Hotta, K. Watanabe
    • Journal Title

      ChemBioChem

      Volume: 13(6) Pages: 855-861

    • Data Source
      KAKENHI-PROJECT-22241054
  • [Journal Article] Development of EST-SSR markers of <i>Ipomoea nil</i>2012

    • Author(s)
      T. Ly, H. Fukuoka, A. Otaka, A. Hoshino, S. Iida, E. Nitasaka, N. Watanabe and T. Kuboyama
    • Journal Title

      Breeding Science

      Volume: 62 Issue: 1 Pages: 99-104

    • DOI

      10.1270/jsbbs.62.99

    • NAID

      130004146342

    • ISSN
      1344-7610, 1347-3735
    • Language
      English
    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22370001, KAKENHI-PROJECT-22770047, KAKENHI-PROJECT-24501059
  • [Journal Article] Establishing a new methodology for genome mining and biosynthesis of polyketides and peptides through yeast molecular genetics2012

    • Author(s)
      Ishiuchi, K., Nakazawa, T., Ookuma, T., Sugimoto, T., Sato, M., Tsunematsu, Y., Ishikawa, N., Noguchi, H., Hotta, K., Moriya, H., Watanabe, K.
    • Journal Title

      ChemBioChem

      Volume: 13 Pages: 846-854

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22241054
  • [Journal Article] Overexpressing transcriptional regulator in Aspergillus oryzae activates a silent biosynthetic pathway to produce novel polyketide2012

    • Author(s)
      Nakazawa, T., Ishiuchi, K., Praseuth, A., Noguchi, H., Hotta, K., Moriya, H., Watanabe, K.
    • Journal Title

      ChemBioChem

      Volume: 13 Pages: 855-861

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22241054
  • [Journal Article] Overexpressing transcriptional regulator in Chaetomium globosum activates a silent biosynthetic pathway: evaluation of shanorellin biosynthesis2012

    • Author(s)
      Y. Tsunematsu, S. Ichinoseki, T. Nakazawa, N. Ishikawa, H. Noguchi, K. Hotta, K. Watanabe
    • Journal Title

      J. of Antibiotics

      Volume: 65(7) Pages: 377-380

    • NAID

      10030955543

    • Data Source
      KAKENHI-PROJECT-22241054
  • [Journal Article] Overexpressing transcriptional regulator in Aspergillus oryzae activates a silent biosynthetic pathway to produce novel polyketide2012

    • Author(s)
      T. Nakazawa, K. Ishiuchi, A. Praseuth, H. Noguchi, K. Hotta, K. Watanabe
    • Journal Title

      ChemBioChem.

      Volume: 13(6) Issue: 6 Pages: 855-861

    • DOI

      10.1002/cbic.201200107

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22241054, KAKENHI-PROJECT-23406031, KAKENHI-PROJECT-23880025
  • [Journal Article] Establishing a New Methodology for Genome Mining and Biosynthesis of Polyketides and Peptides through Yeast Molecular Genetics2012

    • Author(s)
      石内勘一郎、佐藤道大, 他9名
    • Journal Title

      Chembiochem

      Volume: 13 Issue: 6 Pages: 846-854

    • DOI

      10.1002/cbic.201100798

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-10J01668, KAKENHI-PROJECT-22241054, KAKENHI-PROJECT-23310140, KAKENHI-PROJECT-23406031, KAKENHI-PROJECT-23880025
  • [Journal Article] A comprehensive overview on genomically directed assembly of aromatic polyketides and macrolide lactones using fungal megasynthases2011

    • Author(s)
      Saruwatari, T., Praseuth, A.P., Sato, M., Torikai, K., Noguchi, H., Watanabe, K.
    • Journal Title

      J.Antibiot.

      Volume: 64 Pages: 9-17

    • NAID

      10030637198

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22241054
  • [Journal Article] A comprehensive overview on genomically directed assembly of aromatic polyketides and macrolide lactones using fungal megasynthases2011

    • Author(s)
      T. Saruwatari, A. P Praseuth, M. Sato, K. Torikai, H. Noguchi, K. Watanabe
    • Journal Title

      The Journal of Antibiotics

      Volume: 64 Pages: 9-17

    • NAID

      10030637198

    • Data Source
      KAKENHI-PROJECT-22241054
  • [Journal Article] Practical Synthesis of dopa derivative for biosynthetic production of potent antitumor natural products, Saframycins and Ecteinascidin 7432011

    • Author(s)
      K. Torikai, T. Saruwatari, T. Kitano, T. Sano, A. Nakane, H. Noguchi, K. Watanabe
    • Journal Title

      Letters In Organic Chemistry

      Volume: 8-10 Pages: 686-689

    • NAID

      120005133055

    • Data Source
      KAKENHI-PROJECT-22241054
  • [Journal Article] 生合成マシナリーを用いた抗腫瘍性物質生産の試み2011

    • Author(s)
      渡辺賢二
    • Journal Title

      バイオサイエンスとインダストリー

      Volume: 69 Pages: 26-30

    • NAID

      10027617152

    • Data Source
      KAKENHI-PROJECT-21780106
  • [Journal Article] A comprehensive overview on genomically directed assembly of aromatic polyketides and macrolide lactones using fungal megasynthases2011

    • Author(s)
      T.Saruwatari, A.P Praseuth, M.Sato, K.Torikai, H.Noguchi, K.Watanabe
    • Journal Title

      Journal of Antibiotics

      Volume: 64 Pages: 9-17

    • NAID

      10030637198

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22241054
  • [Journal Article] Practical synthesis of DOPA derivative for biosynthetic production of potent antitumor natural products, saframycins and ecteinascidin 7432011

    • Author(s)
      Torikai, K., Saruwatari, T., Kitano, T., Sano, T., Nakane, A., Noguchi, H., Watanabe, K.
    • Journal Title

      Letters In Organic Chemistry

      Volume: 8 Pages: 686-689

    • NAID

      120005133055

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22241054
  • [Journal Article] 生合成マシナリーを用いた抗腫瘍性物質生産の試み,バイオサイエンスとインダストリー2011

    • Author(s)
      渡辺賢二, 大栗博毅, 及川英秋
    • Journal Title

      バイオインダストリー協会 69

      Pages: 26-30

    • Data Source
      KAKENHI-PROJECT-21780106
  • [Journal Article] Reconstruction of the saframycin core scaffold defines dual Pictet-Spengler mechanisms.2010

    • Author(s)
      Koketsu, K., Oguri, H., Watanabe, K., Oikawa, H.
    • Journal Title

      Nature Chemical Biology 6

      Pages: 408-410

    • NAID

      120002646838

    • Data Source
      KAKENHI-PROJECT-21780106
  • [Journal Article] Intriguing substrate tolerance of epoxide hydrolase Lsd19 involved in biosynthesis of the ionophore antibiotic lasalocid A.2010

    • Author(s)
      Matsuura, Y., Shichijo, Y., Minami, A., Migita, A., Oguri, H., Watanabe, M., Tokiwano, T., Watanabe, K., Oikawa, H.
    • Journal Title

      Org.Lett. 12

      Pages: 2226-2229

    • Data Source
      KAKENHI-PROJECT-21780106
  • [Journal Article] Plasmid construction using recombination activity in the fission yeast Schizosaccharomyces pombe.2010

    • Author(s)
      Chino, A., Watanabe, K., Moriya, M.
    • Journal Title

      PLoS One 5

    • Data Source
      KAKENHI-PROJECT-21780106
  • [Journal Article] Identification of a gene cluster of polyether antibiotic lasalocid from Streptomyces lasaliensis.2009

    • Author(s)
      Migita, A., Watanabe, M., Hirose, Y., Watanabe, K., Tokiwano, T., Kinashi, H., Oikawa, H.
    • Journal Title

      Biosci.Biotechnol.Biochem. 73

      Pages: 169-176

    • NAID

      10027536367

    • Data Source
      KAKENHI-PROJECT-21780106
  • [Journal Article] Enzymatic synthesis of molecular skeletons of complex antitumor antibiotics with non-ribosomal peptide synthetases.2009

    • Author(s)
      Watanabe, K., Oguri, H, Oikawa, H.
    • Journal Title

      Journal of Synthetic Organic Chemistry,Japan 67

      Pages: 1152-1160

    • NAID

      10026866717

    • Data Source
      KAKENHI-PROJECT-21780106
  • [Journal Article] Escherichia coli allows efficient modular incorporation of newly isolated quinomycin biosynthetic enzyme into echinomycin biosynthetic pathway for rational design and synthesis of potent antibiotic unnatural natural product.2009

    • Author(s)
      Watanabe, K., Hotta, K., Nakaya, M., Praseuth, A.P., Wang, C.C.C., Inada, D., Takahashi, K., Fukushi, F., Oguri, H., Oikawa, H.
    • Journal Title

      J.Am.Chem.Soc. 131

      Pages: 9347-9353

    • Data Source
      KAKENHI-PROJECT-21780106
  • [Journal Article] Escherichia coli allows efficient modular incorporation of newly isolated quinomycin biosynthetic enzyme into echinomycin biosynthetic pathway for rational design and synthesis of potent antibiotic unnatural product2009

    • Author(s)
      Watanabe, K., et al.
    • Journal Title

      J Am Chem Soc 131

      Pages: 9347-9353

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21780106
  • [Journal Article] Genetic indoctrination of Escherichia coli for innovative drug discovery by way of heterologous expression of the echinomycin biosynthetic pathway.2009

    • Author(s)
      Watanabe, K., Oguri, H., Oikawa, H.
    • Journal Title

      Current Opinion in Chemical Biology 13

      Pages: 189-196

    • Data Source
      KAKENHI-PROJECT-21780106
  • [Journal Article] Sequence and analysis of the SF2575 gene cluster and characterization of key tailoring enzyme.2009

    • Author(s)
      Pickens, L.B., Wang, P., Zhou, H., Kim, W., Watanabe, K., Gomi, S., Tang, Y.
    • Journal Title

      J.Am.Chem.Soc. 131

      Pages: 17677-17689

    • Data Source
      KAKENHI-PROJECT-21780106
  • [Journal Article] Rationally engineered total biosynthesis of a synthetic analogue of natural quinomycin depsipeptide in Escherichia coli2009

    • Author(s)
      Watanabe, K., et al.
    • Journal Title

      ChembioChem 10

      Pages: 1965-1968

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21780106
  • [Journal Article] Chromatin-level regulation of biosynthetic gene clusters.2009

    • Author(s)
      Bok, J.W., Chiang, Y. M., Szewczyk, E., Reyes-Domingez, Y., Davidson, A.D., Sanchez, J.F., Lo, H.C., Watanabe, K., Strauss, J., Oakley, B.R., Wang, C.C.C., Keller, N.P.
    • Journal Title

      Nature Chemical Biology 5

      Pages: 462-464

    • Data Source
      KAKENHI-PROJECT-21780106
  • [Journal Article] Rationally Engineered Total Biosynthesis of a Synthetic Analog of a Natural Quinomycin Depsipeptide in Escherichia coli.2009

    • Author(s)
      Watanabe, K., Hotta, K., Praseuth, A.P., Searcey, M., Wang, C.C.C., Oguri, H., Oikawa, H.
    • Journal Title

      ChemBioChem 10

      Pages: 1965-1968

    • Data Source
      KAKENHI-PROJECT-21780106
  • [Journal Article] Involvement of common intermediate L-3-hydroxyknyurenine in the chromophore biosynthesis of quinomycin family antibiotics.

    • Author(s)
      Hirose, Y., Watanabe, K., Minami, A., Nakamura, T., Oguri, H., Oikawa, H.
    • Journal Title

      J.Antibiot. in press.

    • Data Source
      KAKENHI-PROJECT-21780106
  • [Journal Article] A comprehensive overview on genomically directed assembly of aromatic polyketides and macrolide lactones using fungal megasynthases.

    • Author(s)
      Saruwatari, T., Praseuth, A. P., Sato, M., Torikai, K., Noguchi, H., Watanabe, K.
    • Journal Title

      J.Antibiot. in press.

    • NAID

      10030637198

    • Data Source
      KAKENHI-PROJECT-21780106
  • [Patent] プロバイオティクス大腸菌の二重変異株、該二重変異株から産生される膜小胞、及びそれを用いた製品2024

    • Inventor(s)
      中尾 龍馬、安部 公博、尾花 望、渡辺 賢二
    • Industrial Property Rights Holder
      国立感染症研究所長
    • Industrial Property Rights Type
      特許
    • Industrial Property Number
      2024-033964
    • Filing Date
      2024
    • Data Source
      KAKENHI-PROJECT-22H04979
  • [Patent] コリバクチン産生大腸菌結合性抗体2023

    • Inventor(s)
      渡辺賢二、瀧本陽介
    • Industrial Property Rights Holder
      株式会社アデノプリベント、静岡県公立大学法人
    • Industrial Property Rights Type
      特許
    • Filing Date
      2023
    • Overseas
    • Data Source
      KAKENHI-PROJECT-22H04979
  • [Patent] PCT出願2022

    • Inventor(s)
      周韜、渡辺賢二
    • Industrial Property Rights Holder
      周韜、渡辺賢二
    • Industrial Property Rights Type
      特許
    • Filing Date
      2022
    • Overseas
    • Data Source
      KAKENHI-PROJECT-19H02898
  • [Patent] コリバクチンおよびコリバクチン産生菌の検出方法および検出プローブ2022

    • Inventor(s)
      渡辺賢二、恒松雄太、佐藤道大
    • Industrial Property Rights Holder
      静岡県公立大学法人
    • Industrial Property Rights Type
      特許
    • Filing Date
      2022
    • Acquisition Date
      2023
    • Overseas
    • Data Source
      KAKENHI-PROJECT-22H04979
  • [Patent] コリバクチン産生菌検出用プライマーセット及び検出用キット2019

    • Inventor(s)
      渡辺賢二
    • Industrial Property Rights Holder
      渡辺賢二
    • Industrial Property Rights Type
      特許
    • Industrial Property Number
      2019-027695
    • Filing Date
      2019
    • Data Source
      KAKENHI-PLANNED-16H06449
  • [Patent] コリバクチンおよびコリバクチン産生菌の検出方法および検出プローブ2018

    • Inventor(s)
      渡辺賢二
    • Industrial Property Rights Holder
      渡辺賢二
    • Industrial Property Rights Type
      特許
    • Filing Date
      2018
    • Overseas
    • Data Source
      KAKENHI-PLANNED-16H06449
  • [Patent] カビ類ポリケチド合成遺伝子の酵母での異種発現2010

    • Inventor(s)
      渡辺賢二, 守屋央朗
    • Industrial Property Rights Holder
      静岡県立大学, 岡山大学
    • Industrial Property Number
      2010-181279
    • Filing Date
      2010-08-13
    • Data Source
      KAKENHI-PROJECT-21780106
  • [Patent] カビ類ポリケチド合成遺伝子の酵母での異種発現2010

    • Inventor(s)
      渡辺賢二、守屋央朗
    • Industrial Property Rights Holder
      静岡県立大学、岡山大学
    • Filing Date
      2010-08-13
    • Data Source
      KAKENHI-PROJECT-21780106
  • [Presentation] OSMAC法により見出された放線菌由来天然物の生合成研究2023

    • Author(s)
      小林 裕輝, 遠藤 瞭太, 佐藤 道大, Lopez Julius, 野川 俊彦, 長田 裕之, 渡辺 賢二
    • Organizer
      日本農芸化学会2023年度大会
    • Data Source
      KAKENHI-PLANNED-22H05121
  • [Presentation] Solanoeclepin A生合成経路解明に向けたNicotiana benthamianaへの一過性異種発現における重要中間体cycloartenolおよび関連化合物の単離構造解析について2023

    • Author(s)
      青木 聡樹、岡本 拓実、山本 泰誠、岸本 真治、渡辺 賢二
    • Organizer
      日本薬学会第144年会
    • Data Source
      KAKENHI-PLANNED-22H05121
  • [Presentation] CYTOCHROME P450 FOR CREATION OF DIMERIZED DIKETOPIPERAZINES2023

    • Author(s)
      Micho Sato, Yuji Ogata, Kenji Watanabe
    • Organizer
      International Conference on NATURAL PRODUCT DISCOVERY and DEVELOPMENT in the Genomic Era
    • Int'l Joint Research
    • Data Source
      KAKENHI-PLANNED-22H05121
  • [Presentation] マメ科モデル植物およびその近縁種を用いたダイズシストセンチュウ孵化誘因物質glycinoeclepin A の生合成遺伝子および経路の解明2023

    • Author(s)
      村上 侑太郎、岡本 拓実、岸本 真治、渡辺 賢二
    • Organizer
      日本薬学会第144年会
    • Data Source
      KAKENHI-PLANNED-22H05121
  • [Presentation] OSMAC法により見出された放線菌由来天然物の生合成研究2023

    • Author(s)
      小林 裕輝, 遠藤 瞭太, 佐藤 道大, Lopez Julius, 野川 俊彦, 長田 裕之, 渡辺 賢二
    • Organizer
      日本薬学会 第143年会
    • Data Source
      KAKENHI-PLANNED-22H05121
  • [Presentation] Structural elucidation of natural product colibactin isolated from Escherichia coli in tumor tissues of clinical samples2023

    • Author(s)
      渡辺賢二
    • Organizer
      4th Bandung Shizuoka Food and Pharma Conference
    • Invited
    • Data Source
      KAKENHI-PROJECT-22H04979
  • [Presentation] 天然物生合成遺伝子の発現による遺伝子治療法の確立2023

    • Author(s)
      根岸 天都, 恒松 雄太, 佐藤 道大, 渡辺 賢二
    • Organizer
      日本生薬学会第69回年会
    • Data Source
      KAKENHI-PROJECT-22K19158
  • [Presentation] アズラクトン合成酵素の機能解析2023

    • Author(s)
      青木 義光, 南 歩実, 岸本 真治, 渡辺 賢二
    • Organizer
      日本薬学会 第143年会
    • Data Source
      KAKENHI-PLANNED-22H05121
  • [Presentation] Cladobotryum属真菌が生産するFR901483に対する自己耐性機構の解明2023

    • Author(s)
      坂野 桜子, 中原 実玖, 田村 優衣, 佐藤 道大, 原 幸大, 橋本 博, Tang Yi, 渡辺 賢二
    • Organizer
      日本薬学会 第143年会
    • Data Source
      KAKENHI-PLANNED-22H05121
  • [Presentation] BIOSYNTHETIC STUDY ON FUNGAL METABOLITE, PYRROLIZILACTONE2023

    • Author(s)
      Sakurako Sakano, Micho Sato, Hiroyuki Osada, Kenji Watanabe
    • Organizer
      International Conference on NATURAL PRODUCT DISCOVERY and DEVELOPMENT in the Genomic Era
    • Int'l Joint Research
    • Data Source
      KAKENHI-PLANNED-22H05121
  • [Presentation] アズラクトン合成酵素の機能解析2023

    • Author(s)
      青木 義光, 南 歩実, 岸本 真治, 渡辺 賢二
    • Organizer
      日本農芸化学会2023年度大会
    • Data Source
      KAKENHI-PLANNED-22H05121
  • [Presentation] ClbP特異阻害剤のスクリーニング法2023

    • Author(s)
      周 韜, 佐藤 道大, 渡辺 賢二
    • Organizer
      日本薬学会 第143年会
    • Data Source
      KAKENHI-PROJECT-22H04979
  • [Presentation] 抗腫瘍性抗生物質fumagillin生合成遺伝子のウイルス発現系による新規抗がん治療法の確立2023

    • Author(s)
      根岸 天都, 恒松 雄太, 佐藤 道大, 渡辺 賢二
    • Organizer
      日本薬学会144年会
    • Data Source
      KAKENHI-PROJECT-22K19158
  • [Presentation] サラシナショウマの主成分cimigenolを基点としたde novo transcriptome解析による生合成遺伝子・経路の解明2023

    • Author(s)
      岡本 拓実、岸本 真治、渡辺 賢二
    • Organizer
      日本薬学会第144年会
    • Data Source
      KAKENHI-PLANNED-22H05121
  • [Presentation] Cladobotryum属真菌が生産するFR901483に対する自己耐性機構の解明2023

    • Author(s)
      坂野 桜子, 中原 実玖, 田村 優衣, 佐藤 道大, 原 幸大, 橋本 博, Tang Yi, 渡辺 賢二
    • Organizer
      日本農芸化学会2023年度大会
    • Data Source
      KAKENHI-PLANNED-22H05121
  • [Presentation] 抗腫瘍性抗生物質fumagillin生合成遺伝子のウイルス発現系による新規抗がん遺伝子治療法の確立2023

    • Author(s)
      根岸 天都, 恒松 雄太, 佐藤 道大, 渡辺 賢二
    • Organizer
      日本農芸化学会2024年度大会
    • Data Source
      KAKENHI-PROJECT-22K19158
  • [Presentation] UNCOVERING THE SELF-RESISTANCE MECHANISM AGAINST FR901483 AS A SECONDARY METABOLITE2023

    • Author(s)
      Miku Nakahara, Sakurako Sakano, Yui Tamura, Micho Sato, Kodai Hara, Hiroshi Hashimoto, Kenji Watanabe
    • Organizer
      International Conference on NATURAL PRODUCT DISCOVERY and DEVELOPMENT in the Genomic Era
    • Int'l Joint Research
    • Data Source
      KAKENHI-PLANNED-22H05121
  • [Presentation] 天然物生合成研究と新展開2023

    • Author(s)
      渡辺賢二
    • Organizer
      第24回天然薬物の開発と応用シンポジウム
    • Invited
    • Data Source
      KAKENHI-PROJECT-22H04979
  • [Presentation] Ergosterolの多様な自動酸化機構の解析2023

    • Author(s)
      難波 良太, 岸本 真治, Pengchen Ma, 西川 俊夫, 及川 英秋, 河岸 洋和, Kendall N. Houk, 渡辺 賢二
    • Organizer
      日本薬学会 第143年会
    • Data Source
      KAKENHI-PLANNED-22H05121
  • [Presentation] ジャガイモシストセンチュウ孵化誘因物質solanoeclepin Aおよび類縁体の実用的供給法の構築2023

    • Author(s)
      山口 友喜、渡邊 正悟、岡本 拓実、岸本 真治、渡辺 賢二
    • Organizer
      日本薬学会第144年会
    • Data Source
      KAKENHI-PLANNED-22H05121
  • [Presentation] 担子菌Coprinopsis属由来化合物lagopodin Bからhitoyol Aへの変換を担う細胞外酵素の探索2023

    • Author(s)
      鈴木 詞也, 浅井 しほり, 遠藤 瞭太, 恒松 雄太, 渡辺 賢二
    • Organizer
      日本薬学会 第143年会
    • Data Source
      KAKENHI-PLANNED-22H05121
  • [Presentation] 抗腫瘍性抗生物質fumagillin生合成遺伝子のウイルス発現系による新規抗がん治療法の確立2023

    • Author(s)
      根岸 天都, 恒松 雄太, 佐藤 道大, 渡辺 賢二
    • Organizer
      第24回 天然薬物の開発と応用シンポジウム
    • Data Source
      KAKENHI-PROJECT-22K19158
  • [Presentation] 天然物生合成研究と新展開2023

    • Author(s)
      渡辺賢二
    • Organizer
      第24回天然薬物の開発と応用シンポジウム
    • Invited / Int'l Joint Research
    • Data Source
      KAKENHI-PLANNED-22H05121
  • [Presentation] 糸状菌由来 cochliodone A 生合成におけるポリケタイド還元機構の解明2022

    • Author(s)
      小坂 幹, Christopher Sarmales-Murga, 佐藤 道大, 渡辺 賢
    • Organizer
      日本生薬学会第68回年会
    • Data Source
      KAKENHI-PLANNED-22H05121
  • [Presentation] アズラクトンを経由する糸状菌二次代謝産物の生合成研究2022

    • Author(s)
      南 歩実, 岸本 真治, 渡邉 正悟, 渡辺 賢二
    • Organizer
      日本生薬学会第68回年会
    • Data Source
      KAKENHI-PLANNED-22H05121
  • [Presentation] Cladobotryum属真菌が生産するFR901483に対する自己耐性機構の解明2022

    • Author(s)
      坂野 桜子, 中原 実玖, 田村 優衣, 佐藤 道大, 原 幸大, 橋本 博, Tang Yi, 渡辺 賢二
    • Organizer
      日本生薬学会第68回年会
    • Data Source
      KAKENHI-PLANNED-22H05121
  • [Presentation] アズラクトン合成酵素の機能解析2022

    • Author(s)
      青木 義光, 南 歩実, 岸本 真治, 渡辺 賢二
    • Organizer
      日本生薬学会第68回年会
    • Data Source
      KAKENHI-PLANNED-22H05121
  • [Presentation] Ergosterol 多様化鍵中間体 triradical の発見2022

    • Author(s)
      難波 良太, 岸本 真治, Pengchen Ma, 西川 俊夫, 及川 英秋, 河岸 洋和, Kendall N. Houk, 渡辺 賢二
    • Organizer
      日本生薬学会第68回年会
    • Data Source
      KAKENHI-PLANNED-22H05121
  • [Presentation] Lentopeptin A, B の生合成経路におけるジアステレオマー形成機構の解明2022

    • Author(s)
      松原 有也, 岸本 真治, 渡辺 賢二
    • Organizer
      日本生薬学会第68回年会
    • Data Source
      KAKENHI-PLANNED-22H05121
  • [Presentation] アズラクトン合成酵素の機能解析2022

    • Author(s)
      青木 義光, 南 歩実, 岸本 真治, 渡辺 賢二
    • Organizer
      第9回食品薬学シンポジウム
    • Data Source
      KAKENHI-PLANNED-22H05121
  • [Presentation] Pyrenula sp.由来 pyrenulic acid のビスエーテル環形成メカニズム解明2022

    • Author(s)
      伊藤 優衣, 佐藤 道大, 籠浦 倫美, 石塚 碧, 恒松 雄太, 竹仲 由希子, 棚橋 孝雄, 渡辺 賢二
    • Organizer
      日本生薬学会第68回年会
    • Data Source
      KAKENHI-PLANNED-22H05121
  • [Presentation] Pyrenula sp.に由来する pyrenulic acid の 6,7 縮環エーテル形成機構解明2022

    • Author(s)
      伊藤 優衣, 佐藤 道大, 籠浦 倫美, 石塚 碧, 恒松 雄太, 竹仲 由希子, 棚橋 孝雄, 渡辺 賢二
    • Organizer
      第9回食品薬学シンポジウム
    • Data Source
      KAKENHI-PLANNED-22H05121
  • [Presentation] 反応メカニズムの理解に基づく天然物生合成リデザイン2022

    • Author(s)
      渡辺賢二
    • Organizer
      新学術領域研究 「生合成リデザイン」 取りまとめ公開シンポジウム
    • Invited
    • Data Source
      KAKENHI-PROJECT-19H02898
  • [Presentation] 糸状菌二次代謝における隠されたアズラクトン形成の発見2022

    • Author(s)
      岸本 真治, 南 歩実, 松原 有也, 竹島 実加, 渡邉 正悟, 渡辺 賢二
    • Organizer
      第64回天然有機化合物討論会
    • Data Source
      KAKENHI-PLANNED-22H05121
  • [Presentation] Cladobotryum属真菌が生産するFR901483に対する自己耐性機構の解明2022

    • Author(s)
      坂野 桜子, 中原 実玖, 田村 優衣, 佐藤 道大, 原 幸大, 橋本 博, Tang Yi, 渡辺 賢二
    • Organizer
      第9回食品薬学シンポジウム
    • Data Source
      KAKENHI-PLANNED-22H05121
  • [Presentation] 生物に作らせる未来の天然物合成化学2022

    • Author(s)
      渡辺賢二
    • Organizer
      日本化学会
    • Invited / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-22K19158
  • [Presentation] 糸状菌Aspergillus lentulus由来新規天然物lentopeptinの発見とそのジアステレオマー形成機構解析2022

    • Author(s)
      松原 有也, 岸本 真治, 渡辺 賢二
    • Organizer
      第9回食品薬学シンポジウム
    • Data Source
      KAKENHI-PLANNED-22H05121
  • [Presentation] アズラクトン形成を経由する糸状菌二次代謝産物の生合成研究2022

    • Author(s)
      南 歩実, 岸本 真治, 渡邉 正悟, 渡辺 賢二
    • Organizer
      第9回食品薬学シンポジウム
    • Data Source
      KAKENHI-PLANNED-22H05121
  • [Presentation] 量子化学計算を活用したergosterolの多様な自動酸化機構の解析2022

    • Author(s)
      難波 良太, 岸本 真治, Pengchen Ma, 西川 俊夫, 及川 英秋, 河岸 洋和, Kendall N. Houk, 渡辺 賢二
    • Organizer
      第9回食品薬学シンポジウム
    • Data Source
      KAKENHI-PLANNED-22H05121
  • [Presentation] 糸状菌由来 cochliodone A 生合成におけるポリケタイド還元機構の解明2022

    • Author(s)
      小坂 幹, Christopher Sarmales-Murga, 赤岡 史人, 佐藤 道大, 渡辺 賢二
    • Organizer
      第9回食品薬学シンポジウム
    • Data Source
      KAKENHI-PLANNED-22H05121
  • [Presentation] Structural elucidation of natural product colibactin isolated from Escherichia coli in tumor tissues of clinical samples2021

    • Author(s)
      Kenji Watanabe
    • Organizer
      Pacifichem2021
    • Invited / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-19H02898
  • [Presentation] Diels-Alderaseのジアステレオ選択性および生成物阻害回避メカニズムの解明2021

    • Author(s)
      佐藤道大、岸本真治、Cooper S. Jamiesonc、原幸大、橋本博、恒松雄太、Houk N. Kendall、Yi Tang、渡辺賢二
    • Organizer
      第62回天然有機化合物討論会
    • Data Source
      KAKENHI-PROJECT-19KK0150
  • [Presentation] ヒトがん培養細胞における天然物生合成遺伝子の機能発現2021

    • Author(s)
      松田真弥、恒松雄太、松下拓磨、尾形勇二、 蜂矢志保実、岸本真治、三好規之、渡辺賢二
    • Organizer
      第23回天然薬物の開発と応用シンポジウム
    • Data Source
      KAKENHI-PROJECT-19K22291
  • [Presentation] 大腸がんリスク因子コリバクチンの化学構造解析2021

    • Author(s)
      周 韜、平山 裕一郎、恒松 雄太、鈴木 七海、佐藤 道大、 田中 誠司、内山 奈穂子、合田 幸広、渡辺 賢二
    • Organizer
      第63回天然有機化合物討論会
    • Data Source
      KAKENHI-PROJECT-19H02898
  • [Presentation] 酵素的Diels-Alder反応におけるジアステレオ選択性の制御機構2020

    • Author(s)
      佐藤道大, 岸本真治, Jamieson Cooper, 成田一仁, 前田直哉, 原幸大, 橋本博, 恒松雄太, Houk N. Kendall, Yi Tang, 渡辺賢二
    • Organizer
      日本薬学会第140年会
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-19KK0150
  • [Presentation] Diels-Alderase CghA の全容解明2020

    • Author(s)
      岸本真治, 佐藤道大, Jamieson Cooper, 横山葵, 成田一仁, 前田直哉, 恒松雄太, 原幸大, 橋本博, Houk Kendall N., 渡辺賢二
    • Organizer
      日本農芸化学会2020年度大会
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-19KK0150
  • [Presentation] Diels-Alderaseのジアステレオ選択性および生成物阻害回避メカニズムの解明2020

    • Author(s)
      渡辺賢二
    • Organizer
      新学術領域研究「生合成リデザイン」第9回公開シンポジウム
    • Invited / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-19KK0150
  • [Presentation] Crystallographic characterization of Diels-Alderase binding site and mutational alteration of stereoselectivity2020

    • Author(s)
      渡辺 賢二
    • Organizer
      Let’s leap! Challenges in Organic Chemistry
    • Invited / Int'l Joint Research
    • Data Source
      KAKENHI-PLANNED-16H06449
  • [Presentation] Diastereoselectivity of an octalin-forming Diels-Alderase2020

    • Author(s)
      渡辺 賢二
    • Organizer
      The 10th Korea-Japan Chemical Biology Symposium and 30th Meeting for New Drug Discovery
    • Invited / Int'l Joint Research
    • Data Source
      KAKENHI-PLANNED-16H06449
  • [Presentation] Diastereoselectivity and product inhibition evasion by Diels-Alderase2020

    • Author(s)
      渡辺 賢二
    • Organizer
      1st International Conference on Natural Product Chemistry in Taiwan
    • Invited / Int'l Joint Research
    • Data Source
      KAKENHI-PLANNED-16H06449
  • [Presentation] Diels-Alderase のジアステレオ選択性および生成物阻害回避メカニズムの解明2020

    • Author(s)
      佐藤道大, 岸本真治, Cooper S. Jamieson, 原幸大, 橋本博, 恒松雄太, Houk N. Kendall, Yi Tang, 渡辺賢二
    • Organizer
      第62回天然有機化合物討論会
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-19KK0150
  • [Presentation] Diels-Alderaseのジアステレオ選択性および生成物阻害回避メカニズムの解明2020

    • Author(s)
      渡辺 賢二
    • Organizer
      生物合成系の再設計による複雑骨格機能分子の革新的創成科学、第8回公開シンポジウム
    • Invited / Int'l Joint Research
    • Data Source
      KAKENHI-PLANNED-16H06449
  • [Presentation] Crystallographic characterization of a [4+2]-cyclase binding site and mutational alteration of stereoselectivity2020

    • Author(s)
      渡辺 賢二
    • Organizer
      The 2nd International Symposium on Organic Reaction Mechanism
    • Invited / Int'l Joint Research
    • Data Source
      KAKENHI-PLANNED-16H06449
  • [Presentation] 大腸がんリスク因子コリバクチン産生菌の増殖抑制を目的としたパイロット介入試験2019

    • Author(s)
      渡辺賢二
    • Organizer
      日本がん予防学会学
    • Invited / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-19H02898
  • [Presentation] Crystallographic characterization of a [4+2]-cyclase binding site and mutational alteration of stereoselectivity2018

    • Author(s)
      Kenji Watanabe
    • Organizer
      The 2nd International Symposium on Organic Reaction Mechanism
    • Invited / Int'l Joint Research
    • Data Source
      KAKENHI-PLANNED-16H06449
  • [Presentation] Simple Screening for High-Colibactin Producers from Clinical Samples Using Activity- Based Fluorescent Probe2018

    • Author(s)
      Kenji Watanabe
    • Organizer
      U.S.-Japan Cooperative Medical Sciences Program (USJCMSP)
    • Invited / Int'l Joint Research
    • Data Source
      KAKENHI-PLANNED-16H06449
  • [Presentation] Assay for proinflammatory activity of structurally modified lipid A.2018

    • Author(s)
      Sayaka Ohashi, Tsutomu Hashidume, Noriko Ishiduka, Hisayoshi Hayashi, Yasuaki Kawarasaki, Kenji Watanabe, Yuko Yoshikawa, Noriyuki Miyoshi
    • Organizer
      第23回静岡健康・長寿学術フォーラム
    • Data Source
      KAKENHI-PROJECT-16H03041
  • [Presentation] Lipid A biosynthesis in E. coli cultured in metal-depletion2018

    • Author(s)
      Sayaka Ohashi, Tsutomu Hashidume, Noriko Ishiduka, Hisayoshi Hayashi, Yasuaki Kawarasaki, Kenji Watanabe, Yuko Yoshikawa, Noriyuki Miyoshi
    • Organizer
      Shizuoka ICPF 2018
    • Data Source
      KAKENHI-PROJECT-16H03041
  • [Presentation] Simple Screening for High-Colibactin Producers from Clinical Samples Using Activity- Based Fluorescent Probe2018

    • Author(s)
      Kenji Watanabe
    • Organizer
      30th International Symposium on the Chemistry of Natural Products
    • Invited / Int'l Joint Research
    • Data Source
      KAKENHI-PLANNED-16H06449
  • [Presentation] ENZYMATIC ONE-STEP RING CONTRACTION FOR QUINOLONE BIOSYNTHESIS2018

    • Author(s)
      Kenji Watanabe
    • Organizer
      2nd China-Japan Joint Symposium on Natural Product Biosynthesis
    • Invited / Int'l Joint Research
    • Data Source
      KAKENHI-PLANNED-16H06449
  • [Presentation] Simple Screening for High-Colibactin Producers from Clinical Samples Using Activity- Based Fluorescent Probe2018

    • Author(s)
      Kenji Watanabe
    • Organizer
      6th Biennial International Conference on New Developments in Drug Discovery from Natural Products and Traditional Medicines
    • Invited / Int'l Joint Research
    • Data Source
      KAKENHI-PLANNED-16H06449
  • [Presentation] Disfavored exo-adduct formation by a modified octalin-forming Diels-Alderase2017

    • Author(s)
      渡辺賢二
    • Organizer
      China/Japan Symposium on Natural Product Biosynthesis
    • Invited / Int'l Joint Research
    • Data Source
      KAKENHI-PLANNED-16H06449
  • [Presentation] 実用的物質生産系構築にむけたゲノム情報に基づく 新規生合成システムのリデザイ2017

    • Author(s)
      渡辺賢二
    • Organizer
      生物合成系の再設計による複雑骨格機能分子の革新的創成化学(新学術領域)第一回公開シンポジウム
    • Place of Presentation
      東京大学, 東京
    • Invited / Int'l Joint Research
    • Data Source
      KAKENHI-PLANNED-16H06449
  • [Presentation] Genetic indoctrination of Escherichia coli for finding genotoxins “colibactin” facilitating inflammation-induced colorectal cancer2017

    • Author(s)
      Kenji Watanabe
    • Organizer
      US-Japan Cooperative Medical Sciences Program, 19th International Conference on Emerging Infectious Diseases in the Pacific Rim
    • Place of Presentation
      Seoul, South Korea
    • Year and Date
      2017-02-07
    • Invited / Int'l Joint Research
    • Data Source
      KAKENHI-PLANNED-16H06449
  • [Presentation] Disfavored exo-adduct generation by a modified octalin-forming Diels-Alderase2017

    • Author(s)
      渡辺賢二
    • Organizer
      Society for Industrial Microbiology
    • Invited / Int'l Joint Research
    • Data Source
      KAKENHI-PLANNED-16H06449
  • [Presentation] Genetic indoctrination of Escherichia coli for finding genotoxins colibactin facilitating inflammation-induced colorectal cancer2017

    • Author(s)
      渡辺賢二
    • Organizer
      US-Japan Cooperative Medical Sciences Program Cancer Panel Meeting
    • Invited / Int'l Joint Research
    • Data Source
      KAKENHI-PLANNED-16H06449
  • [Presentation] 立体選択的な環化反応を触媒する酵素CghAの反応機構解析2017

    • Author(s)
      横山葵, 岸本真治, 佐藤道大, 原幸大, 恒松雄太, 橋本博, 渡辺賢二
    • Organizer
      日本薬学会第137年会
    • Place of Presentation
      東北大学、仙台
    • Year and Date
      2017-03-24
    • Data Source
      KAKENHI-PROJECT-15KT0068
  • [Presentation] 立体選択的な環化反応を触媒する酵素CghAの反応機構解析2017

    • Author(s)
      横山葵, 岸本真治, 佐藤道大, 原幸大, 恒松雄太, 橋本博, ※渡辺賢二
    • Organizer
      日本農芸化学会2017年度大会
    • Place of Presentation
      京都女子大学、京都
    • Year and Date
      2017-03-17
    • Data Source
      KAKENHI-PROJECT-15KT0068
  • [Presentation] Pseurotin biosynthesis in fungus2017

    • Author(s)
      渡辺賢二
    • Organizer
      9th US-Japan Seminar: The international Conference of Natural Product Biosynthesis
    • Invited / Int'l Joint Research
    • Data Source
      KAKENHI-PLANNED-16H06449
  • [Presentation] Genetic indoctrination of Escherichia coli for finding genotoxins “colibactin” facilitating inflammation-induced colorectal cancer2017

    • Author(s)
      Kenji Watanabe
    • Organizer
      U.S.-Japan Cooperative Medical Sciences Program (USJCMSP) Cancer Panel Meeting
    • Place of Presentation
      Seoul, Korea
    • Year and Date
      2017-02-07
    • Invited / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-26560450
  • [Presentation] Novel Genotoxins “Colibactin” Produced by E.coli and colon carcinogenesis (In Vitro, In Vivo Experiments)2017

    • Author(s)
      渡辺賢二
    • Organizer
      The 12th international conference and 5th Asian congress on environmental mutagens with the 33rd annual meeting of KSOT/KEMS
    • Invited / Int'l Joint Research
    • Data Source
      KAKENHI-PLANNED-16H06449
  • [Presentation] 冬虫夏草Cordyceps militarisにおけるcordycepin生合成経路の研究2017

    • Author(s)
      天内 優子、崔 宰熏、恒松 雄太、渡辺 賢二、道羅 英夫、鈴木 智大、河岸洋和
    • Organizer
      日本農芸化学会
    • Place of Presentation
      京都女子大学、京都
    • Year and Date
      2017-03-17
    • Data Source
      KAKENHI-PROJECT-26670048
  • [Presentation] Oxidative trans-to-cis isomerization of olefin in polyketide biosynthesis2016

    • Author(s)
      Kenji Watanabe
    • Organizer
      The 13th International Symposium on the Genetics of Industrial Microorganisms
    • Place of Presentation
      Wuhan, People’s Republic of China
    • Year and Date
      2016-10-16
    • Invited / Int'l Joint Research
    • Data Source
      KAKENHI-PLANNED-16H06449
  • [Presentation] Development of catalysts from natural product biosynthesis as reagents for enzymatic syntheses of potential drugs as well as natural products2016

    • Author(s)
      Kenji Watanabe
    • Organizer
      Biosystems Design Symposium 2.0
    • Place of Presentation
      Singapore
    • Year and Date
      2016-03-21
    • Invited / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-15KT0068
  • [Presentation] Aspoquinolone biosynthesis: Non-heme dioxygenase catalyzes atypical oxidations of 6,7-bicycle to form 6,6-quinolone core of viridicatin-type fungal alkaloid2015

    • Author(s)
      Kenji Watanabe
    • Organizer
      Pacifichem 2015
    • Place of Presentation
      Honolulu, Hawaii
    • Year and Date
      2015-12-15
    • Invited / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-15KT0068
  • [Presentation] Elucidation of pyranonigrin biosynthetic pathway reveals mechanism of fused γ-pyrone, exo-methylene and spiral cyclobutane formation2015

    • Author(s)
      Kenji Watanabe
    • Organizer
      Pacifichem 2015
    • Place of Presentation
      Honolulu, Hawaii
    • Year and Date
      2015-12-15
    • Invited / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-15KT0068
  • [Presentation] 大腸がん原因物質コリバクチンの生合成機構の解明2015

    • Author(s)
      佐々侑寿香、石川格靖、小山ふみ、福冨愛実、野口博司、渡辺賢二
    • Organizer
      日本薬学会第135年会(神戸)
    • Place of Presentation
      兵庫医療大学
    • Year and Date
      2015-03-26
    • Data Source
      KAKENHI-PROJECT-26560450
  • [Presentation] 大腸がん原因物質コリバクチンの生合成機構の解明2015

    • Author(s)
      佐々侑寿香、石川格靖、小山ふみ、福冨愛実、野口博司、渡辺賢二
    • Organizer
      日本農芸化学会2015年度大会(岡山)
    • Place of Presentation
      岡山大学
    • Year and Date
      2015-03-28
    • Data Source
      KAKENHI-PROJECT-26560450
  • [Presentation] Biosynthesis of a Cancer&#8211;Inducing Compound in Escherichia coli2015

    • Author(s)
      Masao Oohashi, Yuzuka Sasa, Noriyasu Ishikawa, Hiroshi Noguchi and Kenji Watanabe
    • Organizer
      Pacifichem 2015
    • Place of Presentation
      Honolulu, Hawaii, USA.
    • Year and Date
      2015-12-15
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-26560450
  • [Presentation] 大腸がん原因物質colibactinの化学構造解明2015

    • Author(s)
      大橋雅生、渡辺賢二
    • Organizer
      天然物談話会
    • Place of Presentation
      宮城県岩沼市
    • Year and Date
      2015-07-01
    • Data Source
      KAKENHI-PROJECT-26560450
  • [Presentation] Natural products from fungi2013

    • Author(s)
      Kenji Watanabe
    • Organizer
      3rd International Conference on Natural product Biosynthesis
    • Place of Presentation
      University of California Los Angeles, University of Southern California (USA)
    • Invited
    • Data Source
      KAKENHI-PROJECT-25242067
  • [Presentation] Functional reconstitution of the saframycin biosynthetic enzymes2012

    • Author(s)
      K. Watanabe
    • Organizer
      RCIS International Conference
    • Place of Presentation
      Okayama
    • Data Source
      KAKENHI-PROJECT-22241054
  • [Presentation] Biosynthesis of natural products through a fungal molecular genetics2012

    • Author(s)
      T. Nakazawa, T. Ookuma, S. Sugimoto, S. Ichinoseki, Y. Gotanda, N. Ishikawa, Y. Tsunematsu, K. Ishiuchi, H. Noguchi, K. Watanabe
    • Organizer
      Philipps-Universitat Marburg
    • Place of Presentation
      Germany
    • Data Source
      KAKENHI-PROJECT-22241054
  • [Presentation] Biologically active molecules from fungi2012

    • Author(s)
      Kenji Watanabe
    • Organizer
      第8回天然物生合成日米セミナー
    • Place of Presentation
      淡路
    • Data Source
      KAKENHI-PROJECT-22241054
  • [Presentation] Biosynthesis of Natural Products Through a Fungal Molecular Genetics2012

    • Author(s)
      T. Nakazawa, T. Ookuma, S. Sugimoto, S. Ichinoseki, Y. Gotanda, N. Ishikawa, Y. Tsunematsu, K. Ishiuchi, H. Noguchi, K. Watanabe
    • Organizer
      11th European Conference on Fungal Genetics.
    • Place of Presentation
      Philipps-Universit&#228;t Marburg (Germany)
    • Data Source
      KAKENHI-PROJECT-22241054
  • [Presentation] Yeast, a more manageable non-ribosomal peptide mill for Spirotryprostatin B assembly2011

    • Author(s)
      K. Watanabe
    • Organizer
      11th European Conference on Fungal Genetics. Society for Industrial Microbiology, Annual meeting and exhibition 2011
    • Place of Presentation
      Sheraton New Orleans, New Orleans (LA)
    • Year and Date
      2011-07-24
    • Data Source
      KAKENHI-PROJECT-22241054
  • [Presentation] T. Nakazawa, K. Ishiuchi, K. Hotta, H.Noguchi, H. Moriya, K. Watanabe2011

    • Author(s)
      T. Nakazawa, K. Ishiuchi, K. Hotta, H.Noguchi, H. Moriya, K. Watanabe
    • Organizer
      8th AFMC International Medicinal Chemistry Symposium "Frontier of Medicinal Science"
    • Place of Presentation
      KEIO PLAZA HOTEL TOKYO(東京)
    • Year and Date
      2011-11-29
    • Data Source
      KAKENHI-PROJECT-22241054
  • [Presentation] Yeast, a more manageable non-ribosomal peptide mill for Spirotryprostatin B assembly.2011

    • Author(s)
      K. Watanabe
    • Organizer
      International Union of Microbiological Societies 2011 Congress, Sapporo Convention Center
    • Place of Presentation
      札幌
    • Year and Date
      2011-09-06
    • Data Source
      KAKENHI-PROJECT-22241054
  • [Presentation] 合理的設計に基づく改変生合成遺伝子群を用いた非天然型生物活性環状デプシペプチドの合成2010

    • Author(s)
      渡辺賢二
    • Organizer
      生体触媒化学シンポジウム
    • Place of Presentation
      静岡市
    • Year and Date
      2010-09-24
    • Data Source
      KAKENHI-PROJECT-21780106
  • [Presentation] 生合成遺伝子の大腸菌発現による抗腫瘍性生理活性物質サフラマシンの効率的合成2010

    • Author(s)
      渡辺賢二
    • Organizer
      アステラス病態研究会
    • Place of Presentation
      経団連会館,東京
    • Year and Date
      2010-10-16
    • Data Source
      KAKENHI-PROJECT-21780106
  • [Presentation] 天然物合成を指向した生合成遺伝子の異種発現によるシンセティックバイオロジーの確立2010

    • Author(s)
      渡辺賢二
    • Organizer
      バイオインダストリー協会
    • Place of Presentation
      パシフィコ横浜,横浜
    • Year and Date
      2010-09-29
    • Data Source
      KAKENHI-PROJECT-21780106
  • [Presentation] Rational Design of Natural Products through Controlled Biosynthesis2009

    • Author(s)
      Kenji Watanabe
    • Organizer
      5th Japan-Korea Young Scientists Meeting on Bioorganic and Natural Products Chemistry
    • Place of Presentation
      Shizuoka, JAPAN
    • Data Source
      KAKENHI-PROJECT-21780106
  • [Presentation] Rational Design of Natural Products through Controlled BiosynthesisSociety for Industrial Microbiology2009

    • Author(s)
      Kenji Watanabe
    • Organizer
      Annual meeting and exhibition 2009
    • Place of Presentation
      Westin Harbour Castle Hotel, Toronto, ON, Canada
    • Data Source
      KAKENHI-PROJECT-21780106
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    # of Collaborated Products: 17 results
  • 2.  葛山 智久 (30280952)
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    # of Collaborated Projects: 2 results
    # of Collaborated Products: 5 results
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    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
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    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 24.  KOBAYASHI Hirokazu (80170348)
    # of Collaborated Projects: 1 results
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    # of Collaborated Projects: 1 results
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    # of Collaborated Products: 0 results
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    # of Collaborated Projects: 1 results
    # of Collaborated Products: 8 results
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    # of Collaborated Products: 0 results
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    # of Collaborated Products: 4 results
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    # of Collaborated Products: 1 results

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