Chiba Natsuko 千葉奈津子

… Alternative Names

Researcher Number	50361192
Other IDs
Affiliation (Current)	2022: 東北大学, 加齢医学研究所, 教授
Affiliation (based on the past Project Information) *help	2014 – 2022: 東北大学, 加齢医学研究所, 教授 2007 – 2013: Tohoku University, 加齢医学研究所, 准教授 2004 – 2006: 東北大学, 加齢医学研究所, 助手
Review Section/Research Field	Principal Investigator General surgery / Basic Section 50010:Tumor biology-related / Laboratory medicine / Tumor biology / Tumor therapeutics / Tumor biology Except Principal Investigator Biological Sciences / Digestive surgery / Basic Section 50010:Tumor biology-related
Keywords	Principal Investigator BRCA1 / がん / 癌 / 中心体 / がん関連分子 / 家族性乳癌 / DNA修復 / 乳がん / 細胞分裂 / 遺伝子診断 … More Except Principal Investigator BRCA1 / 機能解析 / p53 / MYH / MLH1 / がん抑制遺伝子 / 遺伝子変異 / ミスセンス変異 / missense mutation / PTEN / 機能診断 / BRCA2 / がん関連遺伝子 / 腫瘍関連遺伝子 / TP53 / 変異 / 食道扁平上皮癌 / BAP1遺伝子 / 脱ユビキチン化 / 癌化 / BAP1 / 中心体 / 乳がん / 翻訳後修飾 / 局在制御 Less

中心体異常とDNA損傷によるゲノム不安定性を標的とする新しいがん治療法の開発Principal Investigator
- Principal Investigator
  
  千葉奈津子
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 50010:Tumor biology-related
- Research Institution
  Tohoku University
BRCA1複合体の中心体制御機構の解析による組織特異的発がん機序の解明
- Principal Investigator
  
  吉野優樹
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 50010:Tumor biology-related
- Research Institution
  Tohoku University
Development of Targeting therapy for centrosome dysregulation in cancerPrincipal Investigator
- Principal Investigator
  
  千葉奈津子
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 50010:Tumor biology-related
- Research Institution
  Tohoku University
Elucidation of regulatory mechanism to maintain genome stability by novel BRCA1-interacting molecules and development of cancer therapyPrincipal Investigator
- Principal Investigator
  
  CHIBA Natsuko
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Tumor biology
- Research Institution
  Tohoku University
Somatic alteration and depleted nuclear expression of BAP1 in human esophageal squamous cell carcinoma; survey for molecular targeted medicine
- Principal Investigator
  
  Mori Takahiro
- Project Period (FY)
  2013 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Digestive surgery
- Research Institution
  Tohoku University
Elucidation of regulatory mechanism of DNA repair factor to overcome intractable breast cancerPrincipal Investigator
- Principal Investigator
  
  Chiba Natsuko
- Project Period (FY)
  2013 – 2015
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Tumor therapeutics
- Research Institution
  Tohoku University
Function of the novel tumor suppressor in cell division and carcinogenesisPrincipal Investigator
- Principal Investigator
  
  Chiba Natsuko
- Project Period (FY)
  2012 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Tumor biology
- Research Institution
  Tohoku University
Analysis of a novel BRCA1-associated protein for new cancer therapyPrincipal Investigator
- Principal Investigator
  
  CHIBA Natsuko
- Project Period (FY)
  2009 – 2011
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  General surgery
- Research Institution
  Tohoku University
Identifcataion of new molecular targets by analysis of multiple DNA repair activity of familial breast cancer susceptibility genePrincipal Investigator
- Principal Investigator
  
  CHIBA Natsuko
- Project Period (FY)
  2006 – 2008
- Research Category
  
  Grant-in-Aid for Young Scientists (A)
- Research Field
  
  General surgery
- Research Institution
  Tohoku University
Development of functional assays for tumor-related genes
- Principal Investigator
  
  ISHIOKA Chikashi
- Project Period (FY)
  2005 – 2009
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Tohoku University
プロテオミクス解析を利用した家族性乳癌原因遺伝子BRCA1の機能診断法の開発Principal Investigator
- Principal Investigator
  
  千葉奈津子
- Project Period (FY)
  2004 – 2005
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Laboratory medicine
- Research Institution
  Tohoku University
がん関連遺伝子変異の検出および機能評価法の開発
- Principal Investigator
  
  ISHIOKA Chikashi
- Project Period (FY)
  2000 – 2004
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Tohoku University

[Book] インフォームドコンセントのための図説シリーズ　抗悪性腫瘍薬-分子標的治療薬-改訂版2015
- Author(s)
  吉野優樹、千葉奈津子
- Total Pages
  120
- Publisher
  医薬ジャーナル社
- Data Source
  KAKENHI-PROJECT-25640086
[Book] 最新遺伝性腫瘍・家族性腫瘍研究と遺伝カウンセリング2015
- Author(s)
  藤田拡樹、千葉奈津子
- Total Pages
  300
- Publisher
  メディカル　ドゥ
- Data Source
  KAKENHI-PROJECT-25640086
[Book] BRCA1 is involved in the transcription-coulpled repair of UV lesions. Nano-Biomedical Engineering 20112012
- Author(s)
  Chiba N and Wei L
- Publisher
  Imperial College Press
- Data Source
  KAKENHI-PROJECT-21591656
[Book] Identification of a novel BARD1-interacting protein and an analysis of its function in the regulation of mitosis. Nano-Biomedical Engineering 20112012
- Author(s)
  Matsuzawa A, Wei L, Kashiwagi R, Shibata S, Mochiduki H, Maseki E, Furukawa Y, Kato K, Shiono M, and Chiba N.
- Publisher
  Imperial College Press
- Data Source
  KAKENHI-PROJECT-21591656
[Book] Regulation of BRCA1 and BARD1 expression levels in Response to DNA damageNano-Biomedical Engineering 20112012
- Author(s)
  Maseki E, Shiono M, Matsuzawa A, Wei L, Kashiwagi R, Furukawa Y, Shibata S, Mochiduki H, Kato K, and Chiba N.
- Publisher
  Imperial College Press
- Data Source
  KAKENHI-PROJECT-21591656
[Book] Nano-Biomedical Engineering 2011, Proceeding of the Tohoku University Global Centre of Excellence Programme, Global Nano-Biomedical Engineering Education and Research Network Centre2012
- Author(s)
  Natsuko Chiba
- Publisher
  Imperial College Press
- Data Source
  KAKENHI-PROJECT-21591656
[Book] BRCA1 responds to DNA damage induced by laser-irradiation. Nano-Biomedical Engineering 20112012
- Author(s)
  Wei L, Kashiwagi R, Furukawa Y, Kato K, and Chiba N.
- Publisher
  Imperial College Press
- Data Source
  KAKENHI-PROJECT-21591656
[Book] Analysis of BRCA1 Accumulation at DNA Double-Strand Breaks Using a Molecular Imaging technique, Nano-Biomedical Engineering 20092009
- Author(s)
  Wei L and Chiba N
- Publisher
  Imperial College Press
- Data Source
  KAKENHI-PROJECT-21591656
[Book] Analysis of Tumor Suppressor Gene Using Molecular Imaging for Personalized Medicine, Nano-Biomedical Engineering 20092009
- Author(s)
  Chiba N and Wei L
- Publisher
  Imperial College Press
- Data Source
  KAKENHI-PROJECT-21591656
[Journal Article] Dysregulation of the centrosome induced by BRCA1 deficiency contributes to tissue‐specific carcinogenesis2021
- Author(s)
  Yoshino Y, Fang Z, Qi H, Kobayashi A, and Chiba N
- Journal Title
  
  Cancer Science
  
  Volume: in press
- DOI
  10.1111/cas.14859
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19H03493, KAKENHI-PROJECT-18K15233
[Journal Article] The function of BARD1 in centrosome regulation in cooperation with BRCA1/OLA1/RACK1.2020
- Author(s)
  Otsuka Kei、Yoshino Yuki、Qi Huicheng、Chiba Natsuko
- Journal Title
  
  Genes
  
  Volume: 11 Pages: 842-842
- DOI
  10.3390/genes11080842
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K18020, KAKENHI-PROJECT-19H03493, KAKENHI-PROJECT-18K15233
[Journal Article] RACK1 regulates centriole duplication through promoting the activation of polo-like kinase 1 by Aurora A2020
- Author(s)
  Yoshino Y*, Kobayashi A*, Qi H, Endo S, Fang Z, Shindo K, Kanazawa R, Chiba N
- Journal Title
  
  Journal of Cell Science
  
  Volume: 133 Pages: 238931-238931
- DOI
  10.1242/jcs.238931
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19H03493, KAKENHI-PROJECT-18K15233
[Journal Article] Relationship among DNA double-strand break (DSB), DSB repair, and transcription prevents genome instability and cancer.2020
- Author(s)
  Ui A, Chiba N, and Yasui A.
- Journal Title
  
  Cancer Science
  
  Volume: 111 Pages: 1443-1451
- DOI
  10.1111/cas.14404
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19H03493
[Journal Article] Interaction between transcription and DSB repair to prevent genome instability and cancer.2020
- Author(s)
  Ui A, Chiba N, and Yasui A.
- Journal Title
  
  Cancer Science
  
  Volume: －
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19H03493
[Journal Article] RACK1 regulates centriole duplication by controlling localization of BRCA1 to the centrosome in mammary tissue-derived cells.2019
- Author(s)
  Yoshino Y, Qi H, Kanazawa R, Sugamata M, Suzuki K, Kobayshi A, Shindo K, Matsuzawa A, Shibata S, Endo S, Miyanishi Y, Shimaoka T, Ishioka C, Kanno S, Yasui A, and Chiba N.
- Journal Title
  
  Oncogene
  
  Volume: 印刷中 Pages: 3077-3092
- DOI
  10.1038/s41388-018-0647-8
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16H04690, KAKENHI-PROJECT-19H03493
[Journal Article] BRCA1-interacting protein OLA1 requires interaction with BARD1 to regulate centrosome number.2018
- Author(s)
  Yoshino Y, Qi H, Fujita H, Shirota M, Abe S, Komiyama Y, Shindo K, Nakayama M, Matsuzawa A, Kobayashi A, Ogoh H, Watanabe T, Ishioka C and Chiba N.
- Journal Title
  
  Molecular Cancer Research
  
  Volume: 6(10) Pages: 1499-1511
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16H04690
[Journal Article] Increased centrosome number in BRCA-related breast cancer specimens determined by immunofluorescence analysis2018
- Author(s)
  Gou Watanabe, Natsuko Chiba, Tadashi Nomizu, Akihiko Furuta, Kaolu Sato, Minoru Miyashita, Hiroshi Tada, Akihiko Suzuki, Noriaki Ohuchi, Takanori Ishida
- Journal Title
  
  Cancer Science
  
  Volume: 印刷中
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16H04690
[Journal Article] Increased centrosome number in BRCA-related breast cancer specimens determined by immunofluorescence analysis2018
- Author(s)
  Watanabe G, Chiba N, Nomizu T, Furuta A, Sato K, Miyashita M, Tada H, Suzuki A, Ohuchi N, Ishida T.
- Journal Title
  
  Cancer Science
  
  Volume: in press Pages: 2027-2035
- DOI
  10.1111/cas.13595
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K15006, KAKENHI-PROJECT-16H04690
[Journal Article] Loss of protein phosphatase 6 in mouse keratinocytes enhances K-ras G12D -driven tumor promotion2018
- Author(s)
  Kurosawa Koreyuki、Inoue Yui、Kakugawa Yoichiro、Yamashita Yoji、Kanazawa Kosuke、Kishimoto Kazuhiro、Nomura Miyuki、Momoi Yuki、Sato Ikuro、Chiba Natsuko、Suzuki Mai、Ogoh Honami、Yamada Hidekazu、Miura Koh、Watanabe Toshio、Tanuma Nobuhiro、Tachi Masahiro、Shima Hiroshi
- Journal Title
  
  Cancer Science
  
  Volume: 109 Pages: 2178-2187
- DOI
  10.1111/cas.13638
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K07187, KAKENHI-PROJECT-17K10660, KAKENHI-PROJECT-18K16043, KAKENHI-PROJECT-16H04690, KAKENHI-PROJECT-16K07296, KAKENHI-PROJECT-16K10486, KAKENHI-PROJECT-16K10774, KAKENHI-PROJECT-17K16358, KAKENHI-PROJECT-17K16876
[Journal Article] Efficacy and safety of gemcitabine plus docetaxel in Japanese patients with unresectable or recurrent bone and soft tissue sarcoma: Results from a single-institutional analysis2017
- Author(s)
  Takahashi M, Komine K, Imai H, Okada Y, Saijo K, Takahashi M, Shirota H, Ohori H, Takahashi S, Chiba N, Mori T, Shimodaira H, Ishioka C.
- Journal Title
  
  PLoS One
  
  Volume: 12(5)
- DOI
  10.1371/journal.pone.0176972
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K07106, KAKENHI-PROJECT-16H04690, KAKENHI-PROJECT-15K08962, KAKENHI-PROJECT-16K10488
[Journal Article] Regulation of centrosome cycle2016
- Author(s)
  Hiroki Fujita, Yuki Yoshino , and Natsuko Chiba
- Journal Title
  
  Molecular & Cellular Oncology
  
  Volume: 3
- DOI
  10.1080/23723556.2015.1075643
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-25640086
[Journal Article] deltaNp63beta induces quiescence and downregulates the BRCA1 pathway in Estrogen receptor-positive luminal breast cancer cell Line MCF7 but not in other breast cancer cell lines.2016
- Author(s)
  Amin R, Morita-Fujimura Y, Tawarayama H, Semba K, Chiba N, Fukumoto M, Ikawa S
- Journal Title
  
  Molecular Oncology
  
  Volume: 10 Pages: 575-593
- DOI
  10.1016/j.molonc.2015.11.009
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15K06733, KAKENHI-PROJECT-16H04690
[Journal Article] OLA1 gene sequencing in patients with BRCA1/2 mutation-negative suspected hereditary breast and ovarian cancer.2016
- Author(s)
  Takahashi M*, Chiba N*, Shimodaira H, Yoshino Y, Mori T, Sumii M, Nomizu T, Ishioka C.
- Journal Title
  
  Breast Cancer
  
  Volume: 24(2) Pages: 336-340
- DOI
  10.1007/s12282-016-0709-0
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-16H04690, KAKENHI-PROJECT-26460958
[Journal Article] Regulation of centrosome cycle2016
- Author(s)
  Hiroki Fujita , Yuki Yoshino, and Nastuko Chiba
- Journal Title
  
  Molecular & Cellular Oncology
  
  Volume: 3
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-24300327
[Journal Article] BRCA1結合分子OLA1の中心体制御能とゲノム安定性の維持機構2015
- Author(s)
  千葉奈津子
- Journal Title
  
  生化学
  
  Volume: 87 Pages: 741-743
- NAID
  40020687424
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-25640086
[Journal Article] Somatic alteration and depleted nuclear expression of BAP1 in human esophageal squamous cell carcinoma2015
- Author(s)
  Mori T, Sumii M, Fujishima F, Ueno K, Emi M, Nagasaki M, Ishioka C, Chiba N
- Journal Title
  
  Cancer Sci.
  
  Volume: 106 (9) Pages: 1118-1129
- DOI
  10.1111/cas.12722
- Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25462010
[Journal Article] BRCA1結合分子OLA1の中心体制御能とゲノム安定性の維持機構2015
- Author(s)
  千葉奈津子
- Journal Title
  
  生化学
  
  Volume: 87 Pages: 741-743
- NAID
  40020687424
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-24300327
[Journal Article] The BRCA1/BARD1-interacting protein OLA1 functions in centrosome regulation2014
- Author(s)
  Matsuzawa A, Kanno S, Nakayama M, Mochiduki H, Wei L, Shimaoka T, Furukawa Y, Kato K, Shibata S, Yasui A, Ishioka C, Chiba N.
- Journal Title
  
  Molecular Cell
  
  Volume: 53 Pages: 101-114
- DOI
  10.1016/j.molcel.2013.10.028
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PLANNED-22131005, KAKENHI-PROJECT-23510059, KAKENHI-PROJECT-24300327, KAKENHI-PROJECT-24310037
[Journal Article] BRCA1とその新規結合分子OLA1による中心体制御能と乳がん発症機構2014
- Author(s)
  千葉奈津子
- Journal Title
  
  実験医学
  
  Volume: 32(6) Pages: 908-910
- Data Source
  KAKENHI-PROJECT-25640086
[Journal Article] 家族性乳がん原因遺伝子産物BRCA1の新規結合分子OLA1の中心体制御機構2014
- Author(s)
  松澤綾子、千葉奈津子
- Journal Title
  
  細胞工学
  
  Volume: 33 Pages: 432-433
- Data Source
  KAKENHI-PROJECT-24300327
[Journal Article] BRCA1とその新規結合分子OLA1による中心体制御能と乳がん発症機構2014
- Author(s)
  千葉奈津子
- Journal Title
  
  実験医学
  
  Volume: 32(6) Pages: 908-910
- Data Source
  KAKENHI-PROJECT-24300327
[Journal Article] Analysis of BRCA1 variants in double strand break repair by homologous recombination and single strand annealing.2013
- Author(s)
  Towler W I, Zhang J, Ransburgh D, Toland A, Ishioka C, Chiba N, and Parvin J D.
- Journal Title
  
  Human Mutation
  
  Volume: 34 Pages: 439-445
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25640086
[Journal Article] Analysis of BRCA1 variants in double strand break repair by homologous recombination and single strand annealing.2013
- Author(s)
  Towler W I, Zhang J, Ransburgh D, Toland A, Ishioka C, Chiba N, and Parvin J D.
- Journal Title
  
  Human Mutation
  
  Volume: 34 Pages: 439-445
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24300327
[Journal Article] Analysis of Tumor Suppressor BRCA1 using Molecular Imaging2012
- Author(s)
  Natsuko Chiba
- Journal Title
  
  Tohoku University Global COE Program, Global Nano-Biomedical Engineering Education and Research Network Centre, Annals of nanoBME
  
  Volume: Vol.5 Pages: 211-220
- Data Source
  KAKENHI-PROJECT-21591656
[Journal Article] Functional differences among BRCAL missense mutations in the control of centrosome duplication.2012
- Author(s)
  Kais Z, Chiba N, Ishioka C, Parvin J D
- Journal Title
  
  Oncogene
  
  Volume: 31(6) Pages: 799-804
- DOI
  10.1038/onc.2011.271
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21591656, KAKENHI-PROJECT-24300327
[Journal Article] 個別化医療のための分子イメージング技術を用いた癌関連分子の機能解析2012
- Author(s)
  千葉奈津子
- Journal Title
  
  東北大学グローバルCOEプログラム新世紀世界の成長焦点に築くナノ医工学拠点ナノ医工学年報
  
  Volume: Vol.5 Pages: 231-240
- NAID
  40019250290
- Data Source
  KAKENHI-PROJECT-21591656
[Journal Article] 新規乳癌関連分子の細胞分裂制御能の解析による発癌機構の解明と治療法の開発2012
- Author(s)
  千葉奈津子
- Journal Title
  
  癌と人
  
  Volume: 39 Pages: 48-49
- NAID
  120004852415
- Data Source
  KAKENHI-PROJECT-24300327
[Journal Article] Identifying the effect of BRCA1 mutations on homologous recombination using cells that express endogenous wild-type2011
- Author(s)
  Parvin J D, Chiba N, and Ransburgh D
- Journal Title
  
  BRCA1
  
  Volume: 48
- DOI
  10.3791/2468
- URL
  http://www.jove.com/index/Details.stp?ID=2468J.Vis.Exp
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21591656
[Journal Article] BRCA1 contributes to transcription-coupled repair of DNA damage through polyubiquitination and degradation of Cockayne syndrome Bprotein2011
- Author(s)
  Wei L, Lan L, Yasui A, Tanaka K, Saijo M, Matsuzawa A, Kashiwagi R, Maseki E, Hu Y, Parvin J D, Ishioka C and Chiba N
- Journal Title
  
  Cancer Science
  
  Volume: 102(10) Pages: 1840-1847
- DOI
  10.1111/j.1349-7006.2011.02037.x
- NAID
  10030243954
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21591656, KAKENHI-PLANNED-22131009
[Journal Article] Identification of breast tumor mutations in BRCA1 that abolish its function in homologous DNA recombination.2010
- Author(s)
  Ransburgh D, Chiba N, Ishioka C, Toland A, and Parvin J D
- Journal Title
  
  Cancer Research
  
  Volume: 70(3) Pages: 988-95
- URL
  http://www.ncbi.nlm.nih.gov/pubmed/20103620
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21591656
[Journal Article] 個別化医療のための分子イメージング技術を用いた癌抑制遺伝子の機能解析2010
- Author(s)
  千葉奈津子
- Journal Title
  
  東北大学グローバルCOEプログラム新世紀世界の成長焦点に築くナノ医工学拠点ナノ医工学年報
  
  Volume: Vol.4 Pages: 222-231
- NAID
  40017238541
- Data Source
  KAKENHI-PROJECT-21591656
[Journal Article] Identification of breast tumor mutations in BRCA1 that abolish its function in homologous DNA recombination2010
- Author(s)
  Ransburgh, D.J., Chiba, N., Ishioka, C., Toland, A.E., Parvin, J. D
- Journal Title
  
  Cancer Res 70
  
  Pages: 988-95
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17015002
[Journal Article] 個別化医療のための分子イメージング技術を用いた癌抑制遺伝子の機能解析2009
- Author(s)
  千葉奈津子
- Journal Title
  
  東北大学グローバルCOEプログラム新世紀世界の成長焦点に築くナノ医工学拠点ナノ医工学年報 Vol.3
  
  Pages: 211-220
- NAID
  40017238541
- Data Source
  KAKENHI-PROJECT-21591656
[Journal Article] Analysis of Tumor Suppressor Gene Using Molecular Imaging for Personalized Medicine2009
- Author(s)
  千葉奈津子
- Journal Title
  
  Tohoku University Global COE Program, Global Nano-Biomedical Engineering Education and Research Network Centre, Annals of nanoBME Vol.3
  
  Pages: 209-218
- Data Source
  KAKENHI-PROJECT-21591656
[Journal Article]2009
- Author(s)
  Natsuko Chiba
- Journal Title
  
  Proceeding of the Tohoku University Global Centre of Excellence Programme, Global Nano-Biomedical Engineering Education and Research Network Centre(Imperial College Press)
  
  Pages: 339-349
- Data Source
  KAKENHI-PROJECT-21591656
[Journal Article] Rapid Recruitment of BRCA1 to DNA Double-Strand Breaks Is Dependent on Its Association with Ku802008
- Author(s)
  Wei, L., Lan, L., Hong, Z., Yasui, A., Ishioka, C., Chiba, N
- Journal Title
  
  Mol Cell Biol 28
  
  Pages: 7380-93
- Data Source
  KAKENHI-PROJECT-17015002
[Journal Article] Rapid recruitment of BRCA1 to DNA double-strand breaks is dependent on its association with Ku802008
- Author(s)
  Wei L, Lan L, Hong Z, Yasui A, Ishioka C, and Chiba N
- Journal Title
  
  Mol. Cell. Biol 28(24)
  
  Pages: 7380-7393
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18689032
[Journal Article] 生殖細胞変異の遺伝子診断-家族性乳癌BRCA1,BRCA2を中心に2007
- Author(s)
  千葉奈津子,下平秀樹,石岡千加史
- Journal Title
  
  実験医学 25(17)(増刊)
- Data Source
  KAKENHI-PROJECT-18689032
[Journal Article] 家族性乳癌の原因遺伝子2007
- Author(s)
  千葉奈津子
- Journal Title
  
  日本臨床増刊 65(6)
  
  Pages: 601-605
- Data Source
  KAKENHI-PROJECT-18689032
[Journal Article] 生殖細胞変異の遺伝子診断-家族性乳癌BRCA1, BRCA2を中心に2007
- Author(s)
  千葉奈津子
- Journal Title
  
  実験医学増刊 25(17)
  
  Pages: 2629-2634
- Data Source
  KAKENHI-PROJECT-18689032
[Journal Article] 家族性乳癌の原因遺伝子2007
- Author(s)
  千葉奈津子,石岡千加史
- Journal Title
  
  日本臨床2007年増刊乳癌ー基礎・臨床のアップデート 65(6)
  
  Pages: 601-605
- Data Source
  KAKENHI-PROJECT-18689032
[Journal Article] A dose escalation study of docetaxel and nedaplatin in patients with relapsed or refractory squamous cell carcinoma of the esophagus pretreated using cisplatin, 5-fluorouracil and radiation2006
- Author(s)
  Yoshioka T , Sakayori M, Kato S, Chiba N, Miyazaki S, Nemoto K, Shibata H, Shimodaira H, Ohtsuka K, Kakudo Y, Sakata Y, and Ishioka C
- Journal Title
  
  Int J Clin Oncol 11(6)
  
  Pages: 454-460
- NAID
  10020571819
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18689032
[Journal Article] 家族性乳癌の遺伝子検査に関わる問題点2006
- Author(s)
  酒寄真人, 千葉奈津子, 河原正典, 白石千子, 武田元博, 野水整, 野口眞三郎, 大内憲明, 竹之下誠一, 石岡千加史
- Journal Title
  
  家族性腫瘍 6(1)
  
  Pages: 7-11
- NAID
  130007540991
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18689032
[Journal Article] BRCA1/BARD1 ubiquitinate phosphorylated RNA polymerase II2005
- Author(s)
  Starita, L.M., Horwitz, A.A., Keogh, M.C., Ishioka, C., Parvin, J.D., Chiba, N
- Journal Title
  
  J Biol Chem 280
  
  Pages: 24498-505
- Data Source
  KAKENHI-PROJECT-17015002
[Presentation] Dysfunction of centrosome regulation by BRCA1-containing complex increases tumor heterogeneity.2020
- Author(s)
  Natsuko Chiba, Huicheng Qi, Yuki Yoshino.
- Organizer
  AACR Virtual Special Conference: Tumor Heterogeneity: Form Single cell to Clinical Impact
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19H03493
[Presentation] DNA修復とDNA損傷応答を標的とした新規がん治療2020
- Author(s)
  千葉奈津子
- Organizer
  第79回日本癌学会学術総会
- Invited
- Data Source
  KAKENHI-PROJECT-19H03493
[Presentation] BRCA1関連乳がんの新たな診断法の開発と発がん機構の解析.2020
- Author(s)
  吉野優樹, 遠藤栞乃, 渡部剛, 千葉奈津子.
- Organizer
  第8回HBOCコンソーシアム学術総会
- Data Source
  KAKENHI-PROJECT-19H03493
[Presentation] リン酸化BRCA1はAurora Aの中心体局在を介してDNA損傷後の中心体増幅を制御する2020
- Author(s)
  斉匯成、吉野優樹、菊池めぐみ、方震宙、石岡千加史、千葉奈津子.
- Organizer
  第79回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-19H03493
[Presentation] BRCA1のゲノム安定性維持能の破綻の発がんと抗がん剤感受性への影響について2019
- Author(s)
  千葉奈津子
- Organizer
  「7大学連携個別化がん医療実践者養成プラン」第54回がんプロセミナー
- Data Source
  KAKENHI-PROJECT-19H03493
[Presentation] A novel BRCA1-interacting protein, RACK1, contributes centriole duplication in mammary cells via regulation of PLK1.2019
- Author(s)
  Yoshino Y, Kobayashi A, Qi H, Endo S, Fang Z, Chiba N.
- Organizer
  第78回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-19H03493
[Presentation] Aurora AによるOLA1のユビキチン化は中心体複製制御に重要である2019
- Author(s)
  方震宙, 齋匯成, 森隆弘, 吉野優樹, 鈴木萌, 石岡千加史, 千葉奈津子.
- Organizer
  第78回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-19H03493
[Presentation] Centrosome regulation by a novel BRCA1 complex: insight into tissue-specific carcinogenesis.2019
- Author(s)
  Yoshino Y, Qi H, Endo S, Fang Z, Otsuka K, Chiba N.
- Organizer
  The 14th International Symposium of the Institute Network for Biomedical Sciences
- Data Source
  KAKENHI-PROJECT-19H03493
[Presentation] RCA1/2によるゲノム安定性維持機構とその機能破綻による発がん2019
- Author(s)
  千葉奈津子
- Organizer
  「がんプロ」特別公開講演会　がんゲノム医療先端レクチャー
- Data Source
  KAKENHI-PROJECT-19H03493
[Presentation] BARD1アイソフォームの発現は中心体の異常な伸長を引き起こす.2019
- Author(s)
  大塚慧, 内山千尋, 吉野優樹, 齋匯成, 千葉奈津子.
- Organizer
  第42回分子生物学会学術総会
- Data Source
  KAKENHI-PROJECT-19H03493
[Presentation] BRCA1はDNA損傷後のAurora Aの中心体局在を制御する.2019
- Author(s)
  菊地めぐみ, 齋匯成, 趙懿, 方震宙, 吉野優樹, 千葉奈津子.
- Organizer
  第３７回染色体ワークショップ・第１８回核ダイナミクス研究会
- Data Source
  KAKENHI-PROJECT-19H03493
[Presentation] 新規BRCA1結合分子であるOLA1とRACK1は中心体複製を制御してゲノム安定性に寄与する2019
- Author(s)
  千葉奈津子, 吉野優樹, 斉匯成, 遠藤栞乃, 方震宙, 石岡千加史, 安井明
- Organizer
  第78回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-19H03493
[Presentation] BRCA1とその関連分子による中心体のDNA損傷応答機構の解明.2019
- Author(s)
  斉匯成, 菊地めぐみ, 大橋和音, 方震宙, 吉野優樹, 千葉奈津子.
- Organizer
  第３７回染色体ワークショップ・第１８回核ダイナミクス研究会
- Data Source
  KAKENHI-PROJECT-19H03493
[Presentation] BRCA１結合分子BIP2の過剰発現はPLK1とAurora Aの活性化により中心体過剰複製を引き起こす2018
- Author(s)
  小林輝大, 吉野優樹, 千葉奈津子
- Organizer
  第77回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-16H04690
[Presentation] 新規BRCA1結合分子RACK1 の中心体複製制御能2018
- Author(s)
  吉野優樹, 齋匯成, 小林輝大, 遠藤栞乃, 方震宙, 千葉奈津子.
- Organizer
  第36回染色体ワークショップ第17回核ダイナミクス研究会
- Data Source
  KAKENHI-PROJECT-16H04690
[Presentation] Function of BRCA1-interacting proteins OLA1 and BIP in centrosome and carcinogenesis2018
- Author(s)
  Yuki Yoshino, Huicheng Qi, Kei Otsuka, and Natsuko Chiba
- Organizer
  BASSER CENTER FOR BRCA 6th Annual Scientific Symposium BRCA1, BRCA2 and Beyond: An Update on hereditary Cancer
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H04690
[Presentation] 中心体制御における新規BRCA1結合因子OLA1とBARD1の相互作用の重要性2018
- Author(s)
  吉野優樹, 齋匯成, 藤田拡樹, 小林輝大, 千葉奈津子.
- Organizer
  第77回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-16H04690
[Presentation] BRCA1結合分子OLA1の中心体のDNA損傷応答における機能2017
- Author(s)
  齋匯成, 方震宙, 新藤一葉, 吉野優樹, 千葉奈津子.
- Organizer
  第34回染色体ワークショップ
- Place of Presentation
  木更津
- Year and Date
  2017-01-11
- Data Source
  KAKENHI-PROJECT-16H04690
[Presentation] BRCA1の新規結合分子Ola1のノックアウトマウスの表現型の解析.2017
- Author(s)
  吉田貴大, 吉野優樹, 小河穂波, 佐々木伯大, 中村保宏, 渡邊利雄, 千葉奈津子.
- Organizer
  生命科学系学会合同年次大会　ConBio2017
- Data Source
  KAKENHI-PROJECT-16H04690
[Presentation] BRCA1 supresses centrosome amplification induced by BIP2 over-expression in mammary epithelial cells.2017
- Author(s)
  Shino Endo, Yuki Yoshino, Akihiro Kobayashi, Qi Huicheng, Natsuko Chiba.
- Organizer
  第75回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-16H04690
[Presentation] BRCA1-interacting protein OLA1 is involved in the centrosomal duplication and response to DNA damage.2017
- Author(s)
  Huicheng Qi, Kazune Ohashi, Fang Zhenzhou, Yuki Yoshino, Natsuko Chiba.
- Organizer
  The 33rd International Symposium of Radiation Biology Center, Kyoto University
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H04690
[Presentation] Function of the novel BRCA1-interacting protein OLA1 in centrosomal regulation and carcinogenesis.2017
- Author(s)
  Yuki Yoshino, Huicheng Qi, Natsuko Chiba.
- Organizer
  2nd Global Onsight Conference on Breast Cancer
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H04690
[Presentation] BRCA1結合分子OLA1による中心体のDNA損傷応答機構の解明2017
- Author(s)
  齋匯成, 吉野優樹, 方震宙,千葉奈津子.
- Organizer
  第69回日本細胞生物学会大会
- Data Source
  KAKENHI-PROJECT-16H04690
[Presentation] DNA損傷後の中心体数の増加のメカニズムの解明.2017
- Author(s)
  斉匯成, 大橋和音, 方震宙, 吉野優樹, 千葉奈津子.
- Organizer
  第34回染色体ワークショップ第15回核ダイナミクス研究会
- Data Source
  KAKENHI-PROJECT-16H04690
[Presentation] 新規中心体制御因子RACK1によるBRCA1中心体局在制御と発がん2017
- Author(s)
  吉野優樹, 小林輝大, 菅股眞美, 早坂美月, 齋匯成, 千葉奈津子.
- Organizer
  第69回日本細胞生物学会大会
- Data Source
  KAKENHI-PROJECT-16H04690
[Presentation] BRCA1-interacting protein OLA1 regulates centrosome amplification induced by DNA damage2017
- Author(s)
  Huicheng Qi, Yuki Yoshino, Natsuko Chiba.
- Organizer
  生命科学系学会合同年次大会　ConBio2017
- Data Source
  KAKENHI-PROJECT-16H04690
[Presentation] 新規BRCA1結合分子BIP2による中心体数制御機の分子機構2016
- Author(s)
  吉野優樹、鈴木健太、菅股眞美、齋匯成、千葉奈津子
- Organizer
  第33回染色体ワークショップ第14回核ダイナミクス研究会
- Place of Presentation
  松島一の坊（宮城県・松島町）
- Year and Date
  2016-01-12
- Data Source
  KAKENHI-PROJECT-24300327
[Presentation] 中心体制御因子としての新規BRCA1結合因子BIP2の同定2016
- Author(s)
  吉野優樹, 齋匯成, 石岡千加史, 安井明, 千葉奈津子.
- Organizer
  第75回日本癌学会学術総会
- Place of Presentation
  横浜
- Year and Date
  2016-10-06
- Data Source
  KAKENHI-PROJECT-16H04690
[Presentation] BRCA1依存性に中心体数を制御する新規中心体タンパク質BIP2の同定2016
- Author(s)
  吉野優樹, 齋匯成, 菅股眞美, 安井明, 千葉奈津子.
- Organizer
  第89回日本生化学会大会
- Place of Presentation
  仙台
- Year and Date
  2016-09-25
- Data Source
  KAKENHI-PROJECT-16H04690
[Presentation] 遺伝性乳がん・卵巣がんの現状と今後の展望2016
- Author(s)
  千葉奈津子
- Organizer
  第75回日本癌学会学術総会
- Place of Presentation
  横浜
- Year and Date
  2016-10-06
- Invited
- Data Source
  KAKENHI-PROJECT-16H04690
[Presentation] BRCA1の新規結合分子OLA1の中心体制御能の破綻と発がん2016
- Author(s)
  千葉奈津子
- Organizer
  第19回　東北家族性腫瘍研究会学術集会
- Place of Presentation
  ＴＫＰガーデンシティ仙台（宮城県・仙台市）
- Year and Date
  2016-01-30
- Data Source
  KAKENHI-PROJECT-24300327
[Presentation] 新規中心体タンパク質BIP2はBRCA1の中心体局在と発がん機構に関与する2016
- Author(s)
  齋匯成, 吉野優樹, 石岡千加史, 千葉奈津子.
- Organizer
  第75回日本癌学会学術総会
- Place of Presentation
  横浜
- Year and Date
  2016-09-25
- Data Source
  KAKENHI-PROJECT-16H04690
[Presentation] BRCA1結合分子OLA1の中心体制御機構の解析2016
- Author(s)
  吉野優樹、藤田拡樹、飯地雄大、齋匯成、小宮山裕平、Linn Kullberg、佐々木勇人、千葉奈津子
- Organizer
  第33回染色体ワークショップ第14回核ダイナミクス研究会
- Place of Presentation
  松島一の坊（宮城県・松島町）
- Year and Date
  2016-01-12
- Data Source
  KAKENHI-PROJECT-24300327
[Presentation] 中心体制御因子Ola1ノックアウトマウスに自然発生した造血器系腫瘍の病理組織学的解析2016
- Author(s)
  飯地雄大、吉野優樹、中村保宏、小河穂波、二口充、藤田拡樹、渡邉利雄、千葉　奈津子
- Organizer
  第20回造血器腫瘍研究会
- Place of Presentation
  かずさアカデミアホール（千葉県・木更津市）
- Year and Date
  2016-01-23
- Data Source
  KAKENHI-PROJECT-24300327
[Presentation] BRCA1結合分子OLA1の中心体制御機構の解析2016
- Author(s)
  吉野優樹、藤田拡樹、飯地雄大、齋匯成、小宮山裕平、Linn Kullberg、佐々木勇人、千葉奈津子
- Organizer
  第33回染色体ワークショップ第14回核ダイナミクス研究会
- Place of Presentation
  松島一の坊（宮城県・松島町）
- Year and Date
  2016-01-12
- Data Source
  KAKENHI-PROJECT-25640086
[Presentation] 新規BRCA1結合分子OLA1と協調したBARD1の中心体制御機構2016
- Author(s)
  藤田拡樹、吉野優樹、阿部舜、小宮山裕平、佐々木勇人、齋匯成、千葉奈津子
- Organizer
  第33回染色体ワークショップ第14回核ダイナミクス研究会
- Place of Presentation
  松島一の坊（宮城県・松島町）
- Year and Date
  2016-01-12
- Data Source
  KAKENHI-PROJECT-24300327
[Presentation] 新規中心体タンパク質BIP2はBRCA1の中心体局在制御に関与する2016
- Author(s)
  新藤一葉, 吉野優樹, 齋匯成, 菅股眞美, 早坂美月, 千葉奈津子.
- Organizer
  第89回日本生化学会大会
- Place of Presentation
  仙台
- Year and Date
  2016-09-25
- Data Source
  KAKENHI-PROJECT-16H04690
[Presentation] OLA1 regulates centrosome number together with BRCA1 and BARD12015
- Author(s)
  藤田拡樹, 吉野優樹, 石岡千加史,千葉奈津子
- Organizer
  第74回日本癌学会学術総会
- Place of Presentation
  名古屋国際会議場（愛知県・名古屋市）
- Year and Date
  2015-10-08
- Data Source
  KAKENHI-PROJECT-24300327
[Presentation] BRCA1結合分子OLA1の中心体制御能の破綻による発がん機構2015
- Author(s)
  藤田拡樹, 吉野優樹, 阿部舜, 齋匯成, 小宮山祐平, 千葉奈津子
- Organizer
  第23回DNA複製・組み換え・修復ワークショップ
- Place of Presentation
  焼津グランドホテル（静岡県・焼津市）
- Year and Date
  2015-10-19
- Data Source
  KAKENHI-PROJECT-24300327
[Presentation] BRCA1結合分子OLA1の中心体制御能の破綻による発がん機構2015
- Author(s)
  千葉奈津子
- Organizer
  第23回DNA複製・組み換え・修復ワークショップ
- Place of Presentation
  焼津グランドホテル（静岡県・焼津市）
- Year and Date
  2015-10-19
- Data Source
  KAKENHI-PROJECT-25640086
[Presentation] OLA1 regulates centrosome number together with BRCA1 and BARD12015
- Author(s)
  藤田拡樹, 吉野優樹, 石岡千加史,千葉奈津子
- Organizer
  第74回日本癌学会学術総会
- Place of Presentation
  名古屋国際会議場（愛知県・名古屋市）
- Year and Date
  2015-10-08
- Data Source
  KAKENHI-PROJECT-25640086
[Presentation] OLA1 and BRCA1/BARD1 heterodimer cooperatively regulate centrosome replication and carcinogenesis2015
- Author(s)
  Hiroki Fujita, Yuki Yoshino, Shun Abe, Kaisei, Sai, Yuhei Komiyama, Chikashi Ishioka, and Natsuko Chiba
- Organizer
  第38回分子生物学会年会・第88回日本生化学会大会合同大会
- Place of Presentation
  神戸ポートアイランド（兵庫県・神戸市）
- Year and Date
  2015-12-01
- Data Source
  KAKENHI-PROJECT-24300327
[Presentation] OLA1 and BRCA1/BARD1 heterodimer cooperatively regulate centrosome replication and carcinogenesis2015
- Author(s)
  Hiroki Fujita, Yuki Yoshino, Shun Abe, Kaisei, Sai, Yuhei Komiyama, Chikashi Ishioka, and Natsuko Chiba
- Organizer
  第38回分子生物学会年会・第88回日本生化学会大会合同大会
- Place of Presentation
  神戸ポートアイランド（兵庫県・神戸市）
- Year and Date
  2015-12-01
- Data Source
  KAKENHI-PROJECT-25640086
[Presentation] Somatic alteration and depleted nuclear expression of BAP1 in human esophageal squamous cell carcinoma．2015
- Author(s)
  Mori, T.，Sumii, M.，Fujishima, F.，Ueno, K.，Emi, M.，Nagasaki, M.，Ishioka, C.，Chiba, N.
- Organizer
  AACR Annual Meeting 2015
- Place of Presentation
  Philadelphia, USA．
- Year and Date
  2015-04-22
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25462010
[Presentation] 切除不能進行再発大腸癌に対するregorafenibとTAS102の治療効果に関する後方視野的検討2015
- Author(s)
  小峰啓吾，小林輝大，伊藤祝栄，大石隆之，岡田佳也，今井源，西條憲，高橋昌宏，高橋雅信，高橋信，城田英和，千葉奈津子，下平秀樹，森隆弘，石岡千加史
- Organizer
  日本癌治療学会学術集会
- Place of Presentation
  京都（国立京都国際会館）
- Year and Date
  2015-10-31
- Data Source
  KAKENHI-PROJECT-25462010
[Presentation] ヒト食道扁平上皮癌でのBAP1遺伝子変異は脱ユビキチン化能を低下させ細胞内局在を変化させる2015
- Author(s)
  森隆弘，千葉奈津子，江見充，石岡千加史，藤島史喜
- Organizer
  日本癌学会学術総会
- Place of Presentation
  名古屋（名古屋国際会議場）
- Year and Date
  2015-10-08
- Data Source
  KAKENHI-PROJECT-25462010
[Presentation] BRCA1の新規結合分子OLA1による中心体制御能とその機能破綻による発がん機構2014
- Author(s)
  千葉奈津子
- Organizer
  第7回Symphony
- Place of Presentation
  東京
- Year and Date
  2014-09-14
- Invited
- Data Source
  KAKENHI-PROJECT-24300327
[Presentation] Analysis of Tumor Suppressor BRCA1 using Molecular Imaging2012
- Author(s)
  Natsuko Chiba
- Organizer
  The 18^<th> International Symposium on Nano-Biomedical Engineering in the East Asian-Pacific Rim Region
- Place of Presentation
  Sendai
- Year and Date
  2012-03-06
- Data Source
  KAKENHI-PROJECT-21591656
[Presentation] Analysis of Tumor Suppressor BRCA1 using Molecular Imaging.2012
- Author(s)
  Chiba N, Furukawa Y, Shibata S, Kato K, Mochiduki H, Shiono M, Maseki E, and Matsuzawa A
- Organizer
  The 18th International Symposium on Nano-Biomedical
- Place of Presentation
  Engineering in the East Asian-Pacific Rim Region (Sendai, Japan)
- Year and Date
  2012-03-06
- Data Source
  KAKENHI-PROJECT-21591656
[Presentation] A novel BARD1-interacting protein regulates centrosome and cytokinesis.2011
- Author(s)
  Matsuzawa A, Shibata S, Mochiduki H, Maseki E, , Furukawa Y, Kato K, Shiono M, and Chiba N
- Organizer
  5th East Asian Pacific Student Workshop on Nano-Biomedical Engineering
- Place of Presentation
  National University of Singapore, Singapore, Singapore
- Year and Date
  2011-12-12
- Data Source
  KAKENHI-PROJECT-21591656
[Presentation] Function of BRCA1 in DNA damage repair and centrosome regulation.2011
- Author(s)
  Chiba N, Matsuzawa A, Kashiwagi R, Maseki E, Kanno S, Wei L, Furukawa Y, Shibata S, Ishioka C, and Yasui A
- Organizer
  The 6th International Symposium of Institute Network
- Place of Presentation
  Tokyo, Japan
- Year and Date
  2011-06-09
- Data Source
  KAKENHI-PROJECT-21591656
[Presentation] Regulation of the level of BRCA1/BARD1 expression.2011
- Author(s)
  Maseki E, Shiono M, Matsuzawa A, Furukawa Y, Shibata S, Mochiduki H, Kato K, and Chiba N
- Organizer
  5th East Asian Pacific Student Workshop on Nano-Biomedical Engineering
- Place of Presentation
  National University of Singapore, Singapore, Singapore
- Year and Date
  2011-12-12
- Data Source
  KAKENHI-PROJECT-21591656
[Presentation] SNPs of Aurora-A are involved in the centrosome regulation of BRCA1 and malignant potential of esophageal cancer. Aurora-Aの一塩基多型はBRCA1による中心体制御と食道癌の悪性度に関与する。2011
- Author(s)
  Matsuzawa A, Mori T, Mochiduki H, Chiba N
- Organizer
  第70回日本癌学会学術総会
- Place of Presentation
  名古屋
- Year and Date
  2011-10-03
- Data Source
  KAKENHI-PROJECT-21591656
[Presentation] Analysis of tumor suppressor gene using Molecular imaging technique for paesonalized medicine2010
- Author(s)
  千葉奈津子
- Organizer
  The 12^<th> Internatopnal Symposium on Nano-Biomedical Engineering in the East Asian-Pacific Rim Region
- Place of Presentation
  Sendai, Japan
- Year and Date
  2010-04-16
- Data Source
  KAKENHI-PROJECT-21591656
[Presentation] The effect of BRCA1 missense mutations on homology directed recombination, BRCA1の点突然変異の相同組み換えへの影響2010
- Author(s)
  Chiba N, Matsuzawa A, Kashiwagi R, Maseki E and Ishioka C
- Organizer
  第69回日本癌学会学術総会
- Place of Presentation
  大阪
- Year and Date
  2010-09-22
- Data Source
  KAKENHI-PROJECT-21591656
[Presentation] BRCA1はDNA単鎖切断修復に関与する2010
- Author(s)
  柏木梨佐、古川裕美子、宇井彩子、松澤綾子、柵木絵美子、柴田峻、石岡千加史、安井明、千葉奈津子
- Organizer
  第33回日本分子生物学会年会
- Place of Presentation
  神戸
- Year and Date
  2010-12-08
- Data Source
  KAKENHI-PROJECT-21591656
[Presentation] Analysis of tumor suppressor gene using Molecular imaging technique for personalized medicine.2010
- Author(s)
  Chiba N, Kashiwagi R, Maseki E, and Matsuzawa A
- Organizer
  The 12th Internatopnal Symposium on Nano-Biomedical Engineering in the East Asian-Pacific Rim Region
- Place of Presentation
  Sendai, Japan
- Year and Date
  2010-03-26
- Data Source
  KAKENHI-PROJECT-21591656
[Presentation] Regulatory mechanism of the level of BRCA1/BARD1 expression following DNA damage.2010
- Author(s)
  aseki E, Kanno S, Matsuzawa A, Kashiwagi R, Furukawa Y, Shibata S, Yasui A, and Chiba N
- Organizer
  4th East Asian Pacific Student Workshop on Nano-Biomedical Engineering
- Place of Presentation
  National University of Singapore, Singapore, Singapore
- Year and Date
  2010-12-16
- Data Source
  KAKENHI-PROJECT-21591656
[Presentation] Regulation of BRCA1/BARD1 expression after DNA damage.2010
- Author(s)
  Maseki E, Kanno S, Matsuzawa A, Kashiwagi R, Wei L, Ishioka C, Yasui A, and Chiba N
- Organizer
  6th World Congress of Biomechanics
- Place of Presentation
  Suntec City, Singapore, Singapore
- Year and Date
  2010-08-03
- Data Source
  KAKENHI-PROJECT-21591656
[Presentation] The effect of BRCA1 missense mutations on homology directed recombination2010
- Author(s)
  Natsuko Chiba
- Organizer
  第69回日本癌学会学術総会
- Place of Presentation
  大阪
- Year and Date
  2010-09-22
- Data Source
  KAKENHI-PROJECT-21591656
[Presentation] Identification of a novel BARD1-interacting protein that regulates centrosome and cytokinesis中心体と細胞質分裂を制御する新規BARD1結合分子の同定2010
- Author(s)
  Matsuzawa A, Wei L, Kashiwagi R, Maseki E, Ishioka C, Yasui A, and Chiba N
- Organizer
  第69回日本癌学会学術総会
- Place of Presentation
  大阪
- Year and Date
  2010-09-24
- Data Source
  KAKENHI-PROJECT-21591656
[Presentation] A novel BARD1-interacting protein functions at cell cycle regulation.2010
- Author(s)
  Matsuzawa A, Kanno S, Wei L, Kashiwagi R, Maseki E, Ishioka C, Yasui A, and Chiba N
- Organizer
  6th World Congress of Biomechanics
- Place of Presentation
  Suntec City, Singapore, Singapore
- Year and Date
  2010-08-03
- Data Source
  KAKENHI-PROJECT-21591656
[Presentation] Identification of a novel BARD1-interacting protein and analyses of its function.2010
- Author(s)
  Matsuzawa A, Kanno S, Wei L, Kashiwagi R, Maseki E, Shibata S, Furukawa Y, Ishioka C, Yasui A, and Chiba N
- Organizer
  4th East Asian Pacific Student Workshop on Nano-Biomedical Engineering
- Place of Presentation
  National University of Singapore, Singapore, Singapore
- Year and Date
  2010-12-16
- Data Source
  KAKENHI-PROJECT-21591656
[Presentation] Regulatory mechanism of the level of BRCA1/BARD1 expression following DNA damage2010
- Author(s)
  Maseki E, Kanno S, Matsuzawa A, Kashiwagi R, Shibata S, Furukawa Y, Wei L, Ishioka C, Yasui A, and Chiba N
- Organizer
  第33回日本分子生物学会年会
- Place of Presentation
  神戸
- Year and Date
  2010-12-08
- Data Source
  KAKENHI-PROJECT-21591656
[Presentation] BRCA1 polyubiquitinates CSB protein in transcription-coupled repair of UV damage2009
- Author(s)
  千葉奈津子
- Organizer
  第68回日本癌学会学術総会
- Place of Presentation
  名古屋
- Year and Date
  2009-10-03
- Data Source
  KAKENHI-PROJECT-21591656
[Presentation] BRCA1のDNA単鎖切断修復能における機能2009
- Author(s)
  柏木梨佐、魏雷震、松澤綾子、柵木絵美子、石岡千加史、安井明、千葉奈津子
- Organizer
  第20回DNA複製・組み換え・修復ワークショップ
- Place of Presentation
  滋賀県彦根市
- Year and Date
  2009-11-01
- Data Source
  KAKENHI-PROJECT-21591656
[Presentation] BRCA1のコケイン症候群CSB蛋白のユビキチン化と転写共役修復への影響2009
- Author(s)
  千葉奈津子、魏雷震、田中亀代次、石岡千加史、安井明
- Organizer
  第20回DNA複製・組み換え・修復ワークショップ
- Place of Presentation
  滋賀県彦根市
- Year and Date
  2009-11-01
- Data Source
  KAKENHI-PROJECT-21591656
[Presentation] BRCA 1 polyubiquitinates CSB protein in transcription-coupled repair of UV damage2009
- Author(s)
  Chiba, N, et al
- Organizer
  68th Annual Meeting of the Japanese Cancer Association
- Place of Presentation
  Pacifico Yokohama Japan
- Year and Date
  2009-10-03
- Data Source
  KAKENHI-PROJECT-17015002
[Presentation] Identification of a new target of cancer therapy by a proteomic study. The 10th Internatopnal Symposium on Nano-Biomedical Engineering2009
- Author(s)
  Chiba N, Matsuzawa A, Wei L, Kashiwagi R, Maseki E, Yasui A, and Kanno S
- Organizer
  in the East Asian-Pacific Rim Region
- Place of Presentation
  Christchurch, New Zealand
- Year and Date
  2009-04-16
- Data Source
  KAKENHI-PROJECT-21591656
[Presentation] BRCA1 polyubiquitinates CSB protein in transcription-coupled repair of UV damage、転写と共役したDNA修復においてBRCA1がコケイン症候群CSB蛋白をユビキチン化する2009
- Author(s)
  千葉奈津子, 魏雷震, 田中亀代次, 安井明, 石岡千加史
- Organizer
  第68回日本癌学会学術総会
- Place of Presentation
  名古屋
- Year and Date
  2009-10-03
- Data Source
  KAKENHI-PROJECT-21591656
[Presentation] A novel BARD1-interacting protein functions at spindle poles and midbody to regulate mitosis and cytokinesis.2009
- Author(s)
  松澤綾子、菅野新一郎、魏雷震、柏木梨佐、柵木絵美子、石岡千加史、安井明、千葉奈津子
- Organizer
  第32回日本分子生物学会年会
- Place of Presentation
  横浜
- Year and Date
  2009-12-11
- Data Source
  KAKENHI-PROJECT-21591656
[Presentation] Tumor suppressor BRCA1 response to DNA single-strand breaks induced by laser micro-irradiation2008
- Author(s)
  Natsuko Chiba
- Organizer
  Th7^<th> Internatopnal Symposium on Nano-Biomedical Engineering (ISNBME-7)
- Place of Presentation
  Tainan, Taiwan
- Year and Date
  2008-10-16
- Data Source
  KAKENHI-PROJECT-18689032
[Presentation] Recruitment of Tumor Suppressor, BRCA1 to DNA double strands induced by lasesr micro irradiation2008
- Author(s)
  Chiba N
- Organizer
  5th International Symposium of 2007 Tohoku University Global COEProgram Global Nano-Biomedical Engineering Education and Research Network Centre, Nano-Biomedical Engineering in the East Asian-Pacific Rim Region
- Place of Presentation
  Matsushima Japan
- Data Source
  KAKENHI-PROJECT-18689032
[Presentation] 家族性乳癌原因遺伝子BRCA1の紫外線損傷への集積2008
- Author(s)
  千葉奈津子, 魏雷震, 蘭利, 佐竹正延, 安井明, 石岡千加史
- Organizer
  第67回日本癌学会学術総会
- Place of Presentation
  名古屋
- Year and Date
  2008-10-28
- Data Source
  KAKENHI-PROJECT-18689032
[Presentation] Rapid accumulation of BRCA1 at DNAdouble-strand breaks is dependent on Ku802008
- Author(s)
  Wei L, Lan L., Hong Z, Yasui A, Satake M, Ishioka C. and Chiba N
- Organizer
  Ataxia-Telamgiectasia Workshop 2008
- Place of Presentation
  Ohtsu Japan
- Data Source
  KAKENHI-PROJECT-18689032
[Presentation] Tumor suppressor BRCA1 response to DNA single-strand breaks induced by laser micro-irradiation2008
- Author(s)
  Chiba N. and Wei L
- Organizer
  The 7th Internatopnal Symposium on Nano-Biomedical Engineering (ISNBME-7)
- Place of Presentation
  Tainan, Taiwan
- Data Source
  KAKENHI-PROJECT-18689032
[Presentation] 家族性乳癌原因遺伝子BRCA1の紫外線損傷への集積2008
- Author(s)
  千葉奈津子
- Organizer
  第67回日本癌学会学術総会
- Place of Presentation
  名古屋市
- Year and Date
  2008-10-28
- Data Source
  KAKENHI-PROJECT-18689032
[Presentation] Domain-dependent accumulation of BRCA1 at the sites of DNA damage2007
- Author(s)
  Chiba N., Wei L, Lan L., Hong Z, Yasui A and Ishioka C
- Organizer
  AACR-NCI-EORTC International conference Molecular targets and Cancer Therapeutics
- Place of Presentation
  San Francisco U.S.A
- Data Source
  KAKENHI-PROJECT-18689032
[Presentation] Two cases of breast cancer responding to trastuzumab monotherapy.. Asia Pacific Medical Education Initiative2007
- Author(s)
  Chiba, N., Yoshioka, T., Takahashi, S., Shibata, H., Kato, S., Shimodaira, H., Otsuka, K., Kakudo, Y., Takahashi, M., Yasuda, K., Sakamoto, Y., Ishioka, C
- Organizer
  3rd Asia Pacific Workshop, Molecular targeted Therapy of Cancer
- Place of Presentation
  Shanghai China
- Year and Date
  2007-03-10
- Data Source
  KAKENHI-PROJECT-17015002
[Presentation] Domain-dependent accumulation of BRCA1 at the sites of DNA damage2007
- Author(s)
  Chiba, N., Ishioka, C
- Organizer
  AACR-NCI-EORTC International conference Molecular targets and Cancer Therapeutics
- Place of Presentation
  San Francisco・U.S. A(poster)
- Year and Date
  2007-10-23
- Data Source
  KAKENHI-PROJECT-17015002
[Presentation] 家族性乳癌原因遺伝子BRCA1のN末端のDNA二本鎖切断への集積2007
- Author(s)
  魏雷震, 千葉奈津子, 蘭利, 佐竹正延, 安井明, 石岡千加史
- Organizer
  第66回日本癌学会学術総会
- Place of Presentation
  横浜
- Year and Date
  2007-10-05
- Data Source
  KAKENHI-PROJECT-18689032
[Presentation] Domain-dependent accumulation of BRCA1 at the sites of DNA damage2007
- Author(s)
  Chiba N.
- Organizer
  AACR-NCI-EORTC International conference Molecular targets and Cancer Therapeutics
- Place of Presentation
  San Francisco U.S.A.
- Data Source
  KAKENHI-PROJECT-18689032
[Presentation] Two cases of breast cancer responding to trastuzumab monotherapy2007
- Author(s)
  Chiba N, Yoshioka T, Takahashi S, Shibata H, Kato S, Shimodaira H, Otsuka K, Kakudo Y, Takahashi M, Yasuda K, Sakamoto Y, and Ishioka C
- Organizer
  Asia Pacific Medical Education Initiative, 3rd Asia Pacific Workshop, Molecular targeted Therapy of Cancer
- Place of Presentation
  Shanghai China
- Data Source
  KAKENHI-PROJECT-18689032
[Presentation] リアルタイム分析による家族性乳癌原因遺伝子BRCA1のDNA損傷への集積2006
- Author(s)
  魏雷震, 千葉奈津子, 蘭利, 安井明, 石岡千加史
- Organizer
  第65回日本癌学会学術総会
- Place of Presentation
  横浜
- Year and Date
  2006-09-28
- Data Source
  KAKENHI-PROJECT-18689032
[Presentation] BRCA1の新規結合分子OLA1の機能破綻と発がん機構
- Author(s)
  千葉奈津子
- Organizer
  第73回日本癌学会学術総会
- Place of Presentation
  横浜
- Year and Date
  2014-09-25 – 2014-09-27
- Invited
- Data Source
  KAKENHI-PROJECT-24300327
[Presentation] 新規BRCA1結合分子OLA1は中心体の複製機構に関与する
- Author(s)
  藤田拡樹, 安井明, 石岡千加史, 千葉奈津子
- Organizer
  第73回日本癌学会学術総会
- Place of Presentation
  横浜
- Year and Date
  2014-09-25 – 2014-09-27
- Data Source
  KAKENHI-PROJECT-24300327
[Presentation] 食道扁平上皮癌でのBAP1遺伝子変異により脱ユビキチン化酵素活性が低下する
- Author(s)
  森隆弘, 住井真紀子, 佐藤秀則, 江見充, 石岡千加史, 千葉奈津子
- Organizer
  第72回日本癌学会学術総会
- Place of Presentation
  パシフィコ横浜
- Data Source
  KAKENHI-PROJECT-25462010
[Presentation] The novel BRCA1-interacting protein OLA1 functions in centrosome regulation
- Author(s)
  Matsuzawa A, Fujita H, Wui X, Saito T, Kanno S, Yasui A, and Chiba N.
- Organizer
  The 9th 3R Symposium
- Place of Presentation
  御殿場
- Year and Date
  2014-11-17 – 2014-11-21
- Data Source
  KAKENHI-PROJECT-24300327
[Presentation] 家族性乳癌原因遺伝子産物BRCA1の新規関連分子の中心体制御能の解析
- Author(s)
  松澤綾子, 柴田峻, 望月寛徳, 菅野新一郎, 古川裕美子, 加藤慧, 石岡千加史, 安井明, 千葉奈津子
- Organizer
  第32回染色体ワークショップ第13回核ダイナミクス研究会
- Place of Presentation
  廿日市
- Year and Date
  2014-12-15 – 2014-12-17
- Data Source
  KAKENHI-PROJECT-24300327
[Presentation] BRCA1の新規結合分子OLA1の中心体制御能の破綻と発がん機構
- Author(s)
  藤田拡樹, 松澤綾子, 仲山真弘, 阿部舜, 呉㬢, 千葉奈津子
- Organizer
  第37回分子生物学会年会
- Place of Presentation
  横浜
- Year and Date
  2014-11-25 – 2014-11-27
- Data Source
  KAKENHI-PROJECT-24300327
[Presentation] 家族性乳がん原因分子Brca1の新規結合分子Ola1の欠損マウスにおける発がん
- Author(s)
  千葉奈津子, 小河穂波, 藤田拡樹, 呉曦, 二口充, 渡邊利雄
- Organizer
  第19回造血器腫瘍研究会
- Place of Presentation
  佐賀
- Year and Date
  2015-01-23 – 2015-01-24
- Data Source
  KAKENHI-PROJECT-24300327
[Presentation] 新規BRCA1/BARD1結合分子OLA1は中心体複製機構に関与する
- Author(s)
  千葉奈津子,菅野新一郎,藤田拡樹,安井明,石岡千加史,松澤綾子
- Organizer
  第37回分子生物学会年会
- Place of Presentation
  横浜
- Year and Date
  2014-11-25 – 2014-11-27
- Data Source
  KAKENHI-PROJECT-24300327
[Presentation] BRCA1の新規結合分子OLA1の機能破綻と発がん機構
- Author(s)
  千葉奈津子
- Organizer
  第73回日本癌学会学術総会
- Place of Presentation
  横浜
- Year and Date
  2014-09-25 – 2014-09-27
- Invited
- Data Source
  KAKENHI-PROJECT-25640086
[Presentation] BRCA1とその関連分子のDNA損傷部位への集積の制御機構
- Author(s)
  原田悠、安井明、千葉奈津子
- Organizer
  第22回DNA複製・組換え・修復ワークショップ
- Place of Presentation
  仙台
- Data Source
  KAKENHI-PROJECT-25640086
[Presentation] BRCA1の新規結合分子Ola1のノックアウトマウスの解析.
- Author(s)
  仲山真弘, 小河穂波, 呉曦, 藤田拡樹, 千葉奈津子.
- Organizer
  平成25年度「個体レベルでのがん研究支援活動」ワークショップ
- Place of Presentation
  大津
- Data Source
  KAKENHI-PROJECT-24300327
[Presentation] 家族性乳がん原因遺伝子BRCA1の新規結合分子の同定とその癌抑制能の解明
- Author(s)
  千葉奈津子、安井明、石岡千加史
- Organizer
  第72回日本癌学会学術総会
- Place of Presentation
  横浜
- Invited
- Data Source
  KAKENHI-PROJECT-24300327

1. 吉野優樹 (60755700)

# of Collaborated Projects: 3 results

# of Collaborated Products: 33 results
2. ISHIOKA Chikashi (60241577)

# of Collaborated Projects: 2 results

# of Collaborated Products: 5 results
3. SHIBATA Hiroyuki (50260071)

# of Collaborated Projects: 2 results

# of Collaborated Products: 1 results
4. KATO Shunsuke (40312657)

# of Collaborated Projects: 2 results

# of Collaborated Products: 1 results
5. KANNO Shin-ichiro (10400417)

# of Collaborated Projects: 2 results

# of Collaborated Products: 12 results
6. WATABANE Toshio (60201208)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
7. 城田松之 (00549462)

# of Collaborated Projects: 2 results

# of Collaborated Products: 2 results
8. SHIMODAIRA Hideki (70373214)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
9. Sugimoto Asako (80281715)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. Mori Takahiro (00323030)

# of Collaborated Projects: 1 results

# of Collaborated Products: 6 results
11. 酒寄真人 (20344666)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
12. 大塚慧 (20772437)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
13. 渡部剛 (70451573)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
14. MIYASHITA Minoru

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
15. TAKAHASHI Masanobu

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
16. TAKAHASHI Hidekazu

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
17. 渡辺利雄

# of Collaborated Projects: 0 results

# of Collaborated Products: 7 results
18. 安井明

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
19. 俵山寛司

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
20. 城田英和

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
21. 佐藤郁郎

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
22. 島礼

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
23. 三浦康

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
24. 井上維

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
25. 角川陽一郎

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
26. 山下洋二

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
27. 桃井勇貴

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
28. 野村美有樹

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Chiba Natsuko 千葉 奈津子

CHIBA Natuko 千葉 奈津子

Research Projects

Research Products

Co-Researchers

中心体異常とDNA損傷によるゲノム不安定性を標的とする新しいがん治療法の開発Principal Investigator

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BRCA1複合体の中心体制御機構の解析による組織特異的発がん機序の解明

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Development of Targeting therapy for centrosome dysregulation in cancerPrincipal Investigator

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Elucidation of regulatory mechanism to maintain genome stability by novel BRCA1-interacting molecules and development of cancer therapyPrincipal Investigator

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Somatic alteration and depleted nuclear expression of BAP1 in human esophageal squamous cell carcinoma; survey for molecular targeted medicine

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Elucidation of regulatory mechanism of DNA repair factor to overcome intractable breast cancerPrincipal Investigator

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Function of the novel tumor suppressor in cell division and carcinogenesisPrincipal Investigator

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Analysis of a novel BRCA1-associated protein for new cancer therapyPrincipal Investigator

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Identifcataion of new molecular targets by analysis of multiple DNA repair activity of familial breast cancer susceptibility genePrincipal Investigator

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Development of functional assays for tumor-related genes

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プロテオミクス解析を利用した家族性乳癌原因遺伝子BRCA1の機能診断法の開発Principal Investigator

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がん関連遺伝子変異の検出および機能評価法の開発

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[Book] インフォームドコンセントのための図説シリーズ 抗悪性腫瘍薬-分子標的治療薬-改訂版2015

Author(s)

Total Pages

Chiba Natsuko 千葉奈津子

CHIBA Natuko 千葉奈津子

[Book] インフォームドコンセントのための図説シリーズ　抗悪性腫瘍薬-分子標的治療薬-改訂版2015