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SAKAMOTO Kimitoshi  坂元 君年

ORCIDConnect your ORCID iD *help
Researcher Number 50361465
Affiliation *help 2011 – 2016 : 弘前大学, 農学生命科学部, 准教授
2011 : The University of Tokyo, 医学(系)研究科(研究院), 助教
2008 : 東大, 医学(系)研究科(研究院), 助教
2007 : The University of Tokyo, 大学院・医学系研究科, 助教
2007 : 東大, 医学(系)研究科(研究院), 助手
2004 – 2005 : 東京大学, 大学院・医学系研究科, 助手
2004 – 2005 : 東大, 医学(系)研究科(研究院), 助手
Review Section/Research Field
Principal Investigator
Parasitology (including Sanitary zoology) / Parasitology (including sanitary zoology)
Keywords
Principal Investigator
ミトコンドリア呼吸鎖 / アスコフラノン / キノール酸化酵素 / シアン耐性末端酸化酵素 / トリパノソーマ / 蠕虫 / コハク酸脱水素酵素 / ロドキノン / ミトコンドリア
  • Research Projects

    (4results)
  • Research Products

    (29results)
  • Co-Researchers

    (13People)
  •  Reaction mechanism analysis and inhibitor screening of helminthic fumarate quinone reductasePrincipal Investigator

    • Principal Investigator
      SAKAMOTO Kimitoshi
    • Project Period (FY)
      2014 – 2016
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Parasitology (including sanitary zoology)
    • Research Institution
      Hirosaki University
  •  Development of the expression system of helminthic mitochondrial quinol-fumarate reductase in bacteria.Principal Investigator

    • Principal Investigator
      SAKAMOTO Kimitoshi
    • Project Period (FY)
      2011 – 2013
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Parasitology (including Sanitary zoology)
    • Research Institution
      Hirosaki University
  •  アフリカトリパノソーマシアン耐性キノール酸化酵素の分子機構Principal Investigator

    • Principal Investigator
      坂元 君年
    • Project Period (FY)
      2007 – 2008
    • Research Category
      Grant-in-Aid for Young Scientists (B)
    • Research Field
      Parasitology (including Sanitary zoology)
    • Research Institution
      The University of Tokyo
  •  アフリカトリパノソーマミトコンドリア末端酸化酵素キノール酸化反応の分子機構Principal Investigator

    • Principal Investigator
      坂元 君年
    • Project Period (FY)
      2004 – 2005
    • Research Category
      Grant-in-Aid for Young Scientists (B)
    • Research Field
      Parasitology (including Sanitary zoology)
    • Research Institution
      The University of Tokyo

All 2017 2016 2015 2014 2013 2012 2011 2006 2005 Other

All Journal Article Presentation

  • [Journal Article] The open form inducer approach for structuresed drug design2017

    • Author(s)
      Inaoka, D. K., Iida, M., Tabuchi, T., Honma, T., Lee, N., Hashimoto, S., Matsuoka, S., Kuranaga, T., Sato,K., Shiba, T., Sakamoto, K., Balogun, E. O., Suzuki, S., Nara, T., Rodrigues da Rocha, J., Montanari, C. A., Tanaka, A., Inoue, H., Kita, K. and Harada, S.
    • Journal Title

      PLoS One

      Volume : 11 Issue : 11 Pages : e0167078

    • Publisher
      Public Library of Science
    • Language
      English
    • Peer Reviewed / Open Access / Acknowledgement Compliant / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-26304041, KAKENHI-PUBLICLY-16H01130, KAKENHI-PROJECT-26253003, KAKENHI-PROJECT-26253025, KAKENHI-PROJECT-15J12403, KAKENHI-PROJECT-26460504, KAKENHI-PROJECT-16K15268
  • [Journal Article] Knockdown of the coenzyme Q synthesis gene Smed-dlp1 affects planarian regeneration and tissue homeostasis2015

    • Author(s)
      Shiobara Y, Harada C, Shiota T, Sakamoto K, Kita K, Tanaka S, Tabata K, Sekie K, Yamamoto Y, Sugiyama T
    • Journal Title

      Redox Biol

      Volume : 6 Pages : 599-606

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-26350915, KAKENHI-PROJECT-26460504
  • [Journal Article] Enhancement of protocatechuate decarboxylase activity for the effective production of muconate from lignin-related aromatic compounds.2014

    • Author(s)
      Sonoki T., Morooka M., Sakamoto K., Otsuka Y., Nakamura M, Jellison J, Goodell B.
    • Journal Title

      Journal of Biotechnology

      Volume : 192 Pages : 71-77

    • Peer Reviewed / Acknowledgement Compliant
    • Data Source
      KAKENHI-PROJECT-26460504, KAKENHI-PROJECT-26850041
  • [Journal Article] Pharmacophore identification of ascofuranone, potent inhibitor of cyanide-insensitive alternative oxidase of Trypanosoma brucei2013

    • Author(s)
      Saimoto H, Kido Y, Haga Y, Sakamoto K, Kita K
    • Journal Title

      The Journal of Biochemistry

      Volume : 153 Pages : 267-273

    • Data Source
      KAKENHI-PROJECT-23590484
  • [Journal Article] Structure of the trypanosome cyanide-insensitive alternative oxidase2013

    • Author(s)
      Shiba T, et al.(他17名)
    • Journal Title

      Proc Natl Acad Sci USA

      Volume : 印刷中 Pages : 4580-4585

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22310158, KAKENHI-PROJECT-23370050, KAKENHI-PROJECT-23402046, KAKENHI-PROJECT-23590484, KAKENHI-PROJECT-24390102, KAKENHI-PROJECT-25670205, KAKENHI-PROJECT-12F02102
  • [Journal Article] Pharmacophore identification of ascofuranone, potent inhibitor of cyanide-insensitive alternative oxidase of Trypanosoma brucei2013

    • Author(s)
      Saimoto, H., Kido, Y., Haga, Y., Sakamoto, K., Kita, K.
    • Journal Title

      The Journal of Biochemistry

      Volume : 153 Pages : 267-273

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23590484
  • [Journal Article] Cloning and characterization of hypoxia-inducible factor-1 subunits from Ascaris suum - a parasitic nematode highly adapted to changes of oxygen conditions during its life cycle2013

    • Author(s)
      Goto, M., Amino, H., Nakajima, M., Tsuji, N., Sakamoto, K., Kita, K.
    • Journal Title

      Gene

      Volume : 516 Pages : 39-47

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23590484
  • [Journal Article] Structure of the trypanosome cyanide-insensitive alternative oxidase2013

    • Author(s)
      Shiba T, Kido Y, Sakamoto K, Inaoka DK, Tsuge C, Tatsumi R, Takahashi G, Balogun EO, Nara T, Aoki T, Honma T, Tanaka A, Inoue M, Matsuoka S, Saimoto H, Moore AL, Harada S, Kita K
    • Journal Title

      Proceedings of the National Academy of Sciences of the United States of America

      Volume : 110 Pages : 4580-4585

    • Data Source
      KAKENHI-PROJECT-23590484
  • [Journal Article] Crystal structure of mitochondrial quinol-fumarate reductase from the parasitic nematode Ascaris suum2012

    • Author(s)
      Shimizu H, Osanai A, Sakamoto K, Inaoka D K, Shiba T, Harada S, Kita K
    • Journal Title

      The Journal of Biochemistry

      Volume : 151 Pages : 589-592

    • Data Source
      KAKENHI-PROJECT-23590484
  • [Journal Article] Crystal structure of mitochondrial quinol-fumarate reductase from the parasitic nematode Ascaris suum2012

    • Author(s)
      Shimizu, H., Osanai, A., Sakamoto, K., Inaoka, D. K., Shiba, T., Harada, S., Kita, K
    • Journal Title

      The Journal of Biochemistry

      Volume : 151 Pages : 589-592

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23590484
  • [Journal Article] Age-related changes in the activities of respiratory chain complexes and mitochondrial morphology in Drosophila2012

    • Author(s)
      Oda Y, Yui R, Sakamoto K, Kita K, Matsuura ET
    • Journal Title

      Mitochondrion

      Volume : 12 Pages : 345-351

    • Data Source
      KAKENHI-PROJECT-23590484
  • [Journal Article] Age-related changes in the activities of respiratory chain complexes and mitochondrial morphology in Drosophila.2011

    • Author(s)
      Oda, Y., Yui, R., Sakamoto, K., Kita, K., Matsuura, E.T.
    • Journal Title

      Mitochondrion

      Volume : 12 Pages : 345-351

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23590484
  • [Journal Article] Uklactones A and B, new NADH-fumarate reductase inhibitors produced by Penicillium sp.FKI-33892011

    • Author(s)
      M.Mori, H.Morimoto, Y.-P.Kim, H.Ui, K.Nonaka, R.Masuma, K.Sakamoto, K.Kita, H.Tomoda, K.Shiomi, S.Omura
    • Journal Title

      Tetrahedron

      Volume : 67 Pages : 6582-6586

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21580129, KAKENHI-PROJECT-23590484
  • [Journal Article] Ukulactones A and B, new NADH-fumarate reductase inhibitors produced by Penicillium sp. FKI-33892011

    • Author(s)
      Mori M, Morimoto H, Kim YP, Ui H, Nonaka K, Masuma R, Sakamoto K, Kita K, Tomoda H, Shiomi K, Omura S
    • Journal Title

      Tetrahedron

      Volume : 67 Pages : 6582-6586

    • Data Source
      KAKENHI-PROJECT-23590484
  • [Journal Article] Differential Kinetics Activities of Glycerol Kinase among African Trypanosome Species: Phylogenetic and Therapeitic Implications.2011

    • Author(s)
      Ohashi-Suzuki, M., Yabu, Y., Ohshima, S., Nakamura, K., Kido, Y., Sakamoto, K., Kita, K., Ohta, N., Suzuki, T.
    • Journal Title

      Journal of Veterinary Medical Science

      Volume : 73 Pages : 615-621

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23590484, KAKENHI-PROJECT-21380186
  • [Journal Article] Mass spectrometric analysis of the ubiquinol-binding site in cytochrome bd from Escherichia coli2006

    • Author(s)
      Matsumoto Y, Murai M, Fujita D, Sakamoto K, Miyoshi H, Yoshida M, Mogi T
    • Journal Title

      The Journal of Biological Chemistry 281

      Pages : 1905-1912

    • Data Source
      KAKENHI-PROJECT-16790244
  • [Journal Article] Identification and characterization of amino acid residues essential for the active site of UDP-N-acetylenolpyruvylglucosamine reductase (MurB) from Staphylococcus aureus2006

    • Author(s)
      Nishida S, Kurokawa K, Matsuo M, Sakamoto K, Ueno K, Kita K, Sekimizu K
    • Journal Title

      The Journal of Biological Chemistry 281

      Pages : 1714-1724

    • Data Source
      KAKENHI-PROJECT-16790244
  • [Journal Article] Alternative Oxidase (AOX) Genes of African Trypanosomes : Phylogeny and Evolution of AOX and Plastid Terminal Oxidase Families2005

    • Author(s)
      Suzuki T, Hashimoto T, Yabu Y, Majiwa PA, Ohshima S, Suzuki M, Lu S, Hato M, Kido Y, Sakamoto K, Nakamura K, Kita K, Ohta N
    • Journal Title

      The Journal of Eukaryotic Microbiology 52

      Pages : 374-381

    • Data Source
      KAKENHI-PROJECT-16790244
  • [Journal Article] Mutational analysis of the Trypanosoma vivax alternative oxidase : The E(X)_6Y motif is conserved in both mitochondrial alternative oxidase and plastid terminal oxidase and is indispensable for enzyme activity2005

    • Author(s)
      Nakamura K, Sakamoto K, Kido Y, Fujimoto Y, Suzuki T, Suzuki M, Yabu Y, Ohta N, Tsuda A, Onuma M, Kita K.
    • Journal Title

      Biochemical and Biophysical Research Communications 334

      Pages : 593-600

    • Data Source
      KAKENHI-PROJECT-16790244
  • [Presentation] Rhodobacter capsulatus由来bdキノール酸化酵素の解析2016

    • Author(s)
      坂元君年, 佐々木智子, Fevzi Daldal
    • Organizer
      日本生化学会東北支部第82回例会
    • Place of Presentation
      弘前大学
    • Year and Date
      2016-05-21
    • Data Source
      KAKENHI-PROJECT-26460504
  • [Presentation] ユビキノンおよびロドキノンの機能研究材料としてのプラナリア2016

    • Author(s)
      鎌田紗綾, 坂元君年
    • Organizer
      第89回日本生化学会大会
    • Place of Presentation
      東北大学
    • Year and Date
      2016-09-25
    • Data Source
      KAKENHI-PROJECT-26460504
  • [Presentation] アルファプロテオバクテリア綱の細菌が持つコハク酸脱水素酵素の鉄硫黄クラスター近傍アミノ酸変異による活性制御の解析2016

    • Author(s)
      前田晴香、Fevzi Daldal、坂元君年
    • Organizer
      日本農芸化学会2016年大会
    • Place of Presentation
      札幌コンベンションセンター
    • Year and Date
      2016-03-27
    • Data Source
      KAKENHI-PROJECT-26460504
  • [Presentation] Rhodobacter capsulatusとRhodospirillum rubrum間でのキメラ型コハク酸‐ユビキノン還元酵素の作製2013

    • Author(s)
      福士実咲・柴谷恵太・Hendri Aldrat・北潔・Fevzi Daldal・坂元君年
    • Organizer
      第86回日本生化学会大会
    • Place of Presentation
      パシフィコ横浜・横浜
    • Data Source
      KAKENHI-PROJECT-23590484
  • [Presentation] Rhodobacter capsulatusとRhodospirillum rubrum間でのキメラ型コハク酸‐ユビキノン還元酵素の作製2013

    • Author(s)
      福士 実咲、柴谷 恵太、Hendri Aldrat、北 潔、Fevzi Daldal、坂元 君年
    • Organizer
      第86回日本生化学会大会
    • Place of Presentation
      パシフィコ横浜
    • Data Source
      KAKENHI-PROJECT-23590484
  • [Presentation] 紅色光合成細菌Rhodobacter capsulatusを用いたコハク酸脱水素酵素複合体の異種生物間発現2012

    • Author(s)
      坂元君年・Hendri Aldrat・北潔
    • Organizer
      日本農芸化学会2012年度大会
    • Place of Presentation
      京都女子大学
    • Data Source
      KAKENHI-PROJECT-23590484
  • [Presentation] コハク酸脱水素酵素複合体の異種生物間発現系の開発2011

    • Author(s)
      坂元君年・Hendri Aldrat・北潔
    • Organizer
      日本農芸化学会東北支部第146回大会
    • Place of Presentation
      山形大学
    • Data Source
      KAKENHI-PROJECT-23590484
  • [Presentation] コハク酸脱水素酵素複合体の異種生物間発現系の開発

    • Author(s)
      坂元 君年、Hendri Aldrat、北 潔
    • Organizer
      日本農芸化学会東北支部
    • Place of Presentation
      山形大学農学部
    • Data Source
      KAKENHI-PROJECT-23590484
  • [Presentation] 紅色光合成細菌Rhodobacter capsulatusを用いたコハク酸脱水素酵素複合体の異種生物間発現

    • Author(s)
      坂元 君年、Aldrat Hendri、北 潔
    • Organizer
      日本農芸化学会
    • Place of Presentation
      京都女子大学
    • Data Source
      KAKENHI-PROJECT-23590484
  • [Presentation] 淡水性プラナリアからのミトコンドリア単離

    • Author(s)
      室川聡大、櫻田拓也、坂元君年
    • Organizer
      第87回生化学会大会
    • Place of Presentation
      国立京都国際会館
    • Year and Date
      2014-10-15 – 2014-10-18
    • Data Source
      KAKENHI-PROJECT-26460504
  • 1.  LEE Wei
    # of Collaborated Projects : 0results
    # of Collaborated Products : 1results
  • 2.  KITA Kiyoshi
    # of Collaborated Projects : 0results
    # of Collaborated Products : 1results
  • 3.  Inoue Masayuki
    # of Collaborated Projects : 0results
    # of Collaborated Products : 1results
  • 4.  TAKEFUMI Kuranaga
    # of Collaborated Projects : 0results
    # of Collaborated Products : 1results
  • 5.  HARADA Shigeharu
    # of Collaborated Projects : 0results
    # of Collaborated Products : 2results
  • 6.  SONOKI TOMONORI
    # of Collaborated Projects : 0results
    # of Collaborated Products : 1results
  • 7.  NARA Takeshi
    # of Collaborated Projects : 0results
    # of Collaborated Products : 2results
  • 8.  SHIOMI Kazuro
    # of Collaborated Projects : 0results
    # of Collaborated Products : 1results
  • 9.  MASUMA Rokuro
    # of Collaborated Projects : 0results
    # of Collaborated Products : 1results
  • 10.  INOUE Noboru
    # of Collaborated Projects : 0results
    # of Collaborated Products : 1results
  • 11.  WATANABE Jyunichi
    # of Collaborated Projects : 0results
    # of Collaborated Products : 1results
  • 12.  YAMAMOTO Yorihiro
    # of Collaborated Projects : 0results
    # of Collaborated Products : 1results
  • 13.  稲岡 健ダニエル
    # of Collaborated Projects : 0results
    # of Collaborated Products : 1results

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