SAKAMOTO Kimitoshi 坂元君年

Researcher Number	50361465
Affiliation *help	2011 – 2016 : 弘前大学, 農学生命科学部, 准教授 2011 : The University of Tokyo, 医学(系)研究科(研究院), 助教 2008 : 東大, 医学(系)研究科(研究院), 助教 2007 : The University of Tokyo, 大学院・医学系研究科, 助教 2007 : 東大, 医学(系)研究科(研究院), 助手 2004 – 2005 : 東京大学, 大学院・医学系研究科, 助手 2004 – 2005 : 東大, 医学(系)研究科(研究院), 助手
Review Section/Research Field	Principal Investigator Parasitology (including Sanitary zoology) / Parasitology (including sanitary zoology)
Keywords	Principal Investigator ミトコンドリア呼吸鎖 / アスコフラノン / キノール酸化酵素 / シアン耐性末端酸化酵素 / トリパノソーマ / 蠕虫 / コハク酸脱水素酵素 / ロドキノン / ミトコンドリア

Reaction mechanism analysis and inhibitor screening of helminthic fumarate quinone reductasePrincipal Investigator
- Principal Investigator
  
  SAKAMOTO Kimitoshi
- Project Period (FY)
  2014 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Parasitology (including sanitary zoology)
- Research Institution
  Hirosaki University
Development of the expression system of helminthic mitochondrial quinol-fumarate reductase in bacteria.Principal Investigator
- Principal Investigator
  
  SAKAMOTO Kimitoshi
- Project Period (FY)
  2011 – 2013
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Parasitology (including Sanitary zoology)
- Research Institution
  Hirosaki University
アフリカトリパノソーマシアン耐性キノール酸化酵素の分子機構Principal Investigator
- Principal Investigator
  
  坂元君年
- Project Period (FY)
  2007 – 2008
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Parasitology (including Sanitary zoology)
- Research Institution
  The University of Tokyo
アフリカトリパノソーマミトコンドリア末端酸化酵素キノール酸化反応の分子機構Principal Investigator
- Principal Investigator
  
  坂元君年
- Project Period (FY)
  2004 – 2005
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Parasitology (including Sanitary zoology)
- Research Institution
  The University of Tokyo

All 2017 2016 2015 2014 2013 2012 2011 2006 2005 Other

All Journal Article Presentation

[Journal Article] The open form inducer approach for structuresed drug design2017
- Author(s)
  Inaoka, D. K., Iida, M., Tabuchi, T., Honma, T., Lee, N., Hashimoto, S., Matsuoka, S., Kuranaga, T., Sato,K., Shiba, T., Sakamoto, K., Balogun, E. O., Suzuki, S., Nara, T., Rodrigues da Rocha, J., Montanari, C. A., Tanaka, A., Inoue, H., Kita, K. and Harada, S.
- Journal Title
  
  PLoS One
  
  Volume : 11 Issue : 11 Pages : e0167078
- Publisher
  Public Library of Science
- Language
  English
- Peer Reviewed / Open Access / Acknowledgement Compliant / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26304041, KAKENHI-PUBLICLY-16H01130, KAKENHI-PROJECT-26253003, KAKENHI-PROJECT-26253025, KAKENHI-PROJECT-15J12403, KAKENHI-PROJECT-26460504, KAKENHI-PROJECT-16K15268
[Journal Article] Knockdown of the coenzyme Q synthesis gene Smed-dlp1 affects planarian regeneration and tissue homeostasis2015
- Author(s)
  Shiobara Y, Harada C, Shiota T, Sakamoto K, Kita K, Tanaka S, Tabata K, Sekie K, Yamamoto Y, Sugiyama T
- Journal Title
  
  Redox Biol
  
  Volume : 6 Pages : 599-606
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-26350915, KAKENHI-PROJECT-26460504
[Journal Article] Enhancement of protocatechuate decarboxylase activity for the effective production of muconate from lignin-related aromatic compounds.2014
- Author(s)
  Sonoki T., Morooka M., Sakamoto K., Otsuka Y., Nakamura M, Jellison J, Goodell B.
- Journal Title
  
  Journal of Biotechnology
  
  Volume : 192 Pages : 71-77
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-26460504, KAKENHI-PROJECT-26850041
[Journal Article] Pharmacophore identification of ascofuranone, potent inhibitor of cyanide-insensitive alternative oxidase of Trypanosoma brucei2013
- Author(s)
  Saimoto H, Kido Y, Haga Y, Sakamoto K, Kita K
- Journal Title
  
  The Journal of Biochemistry
  
  Volume : 153 Pages : 267-273
- Data Source
  KAKENHI-PROJECT-23590484
[Journal Article] Structure of the trypanosome cyanide-insensitive alternative oxidase2013
- Author(s)
  Shiba T, et al.（他17名）
- Journal Title
  
  Proc Natl Acad Sci USA
  
  Volume : 印刷中 Pages : 4580-4585
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22310158, KAKENHI-PROJECT-23370050, KAKENHI-PROJECT-23402046, KAKENHI-PROJECT-23590484, KAKENHI-PROJECT-24390102, KAKENHI-PROJECT-25670205, KAKENHI-PROJECT-12F02102
[Journal Article] Pharmacophore identification of ascofuranone, potent inhibitor of cyanide-insensitive alternative oxidase of Trypanosoma brucei2013
- Author(s)
  Saimoto, H., Kido, Y., Haga, Y., Sakamoto, K., Kita, K.
- Journal Title
  
  The Journal of Biochemistry
  
  Volume : 153 Pages : 267-273
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23590484
[Journal Article] Cloning and characterization of hypoxia-inducible factor-1 subunits from Ascaris suum - a parasitic nematode highly adapted to changes of oxygen conditions during its life cycle2013
- Author(s)
  Goto, M., Amino, H., Nakajima, M., Tsuji, N., Sakamoto, K., Kita, K.
- Journal Title
  
  Gene
  
  Volume : 516 Pages : 39-47
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23590484
[Journal Article] Structure of the trypanosome cyanide-insensitive alternative oxidase2013
- Author(s)
  Shiba T, Kido Y, Sakamoto K, Inaoka DK, Tsuge C, Tatsumi R, Takahashi G, Balogun EO, Nara T, Aoki T, Honma T, Tanaka A, Inoue M, Matsuoka S, Saimoto H, Moore AL, Harada S, Kita K
- Journal Title
  
  Proceedings of the National Academy of Sciences of the United States of America
  
  Volume : 110 Pages : 4580-4585
- Data Source
  KAKENHI-PROJECT-23590484
[Journal Article] Crystal structure of mitochondrial quinol-fumarate reductase from the parasitic nematode Ascaris suum2012
- Author(s)
  Shimizu H, Osanai A, Sakamoto K, Inaoka D K, Shiba T, Harada S, Kita K
- Journal Title
  
  The Journal of Biochemistry
  
  Volume : 151 Pages : 589-592
- Data Source
  KAKENHI-PROJECT-23590484
[Journal Article] Crystal structure of mitochondrial quinol-fumarate reductase from the parasitic nematode Ascaris suum2012
- Author(s)
  Shimizu, H., Osanai, A., Sakamoto, K., Inaoka, D. K., Shiba, T., Harada, S., Kita, K
- Journal Title
  
  The Journal of Biochemistry
  
  Volume : 151 Pages : 589-592
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23590484
[Journal Article] Age-related changes in the activities of respiratory chain complexes and mitochondrial morphology in Drosophila2012
- Author(s)
  Oda Y, Yui R, Sakamoto K, Kita K, Matsuura ET
- Journal Title
  
  Mitochondrion
  
  Volume : 12 Pages : 345-351
- Data Source
  KAKENHI-PROJECT-23590484
[Journal Article] Age-related changes in the activities of respiratory chain complexes and mitochondrial morphology in Drosophila.2011
- Author(s)
  Oda, Y., Yui, R., Sakamoto, K., Kita, K., Matsuura, E.T.
- Journal Title
  
  Mitochondrion
  
  Volume : 12 Pages : 345-351
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23590484
[Journal Article] Uklactones A and B, new NADH-fumarate reductase inhibitors produced by Penicillium sp.FKI-33892011
- Author(s)
  M.Mori, H.Morimoto, Y.-P.Kim, H.Ui, K.Nonaka, R.Masuma, K.Sakamoto, K.Kita, H.Tomoda, K.Shiomi, S.Omura
- Journal Title
  
  Tetrahedron
  
  Volume : 67 Pages : 6582-6586
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21580129, KAKENHI-PROJECT-23590484
[Journal Article] Ukulactones A and B, new NADH-fumarate reductase inhibitors produced by Penicillium sp. FKI-33892011
- Author(s)
  Mori M, Morimoto H, Kim YP, Ui H, Nonaka K, Masuma R, Sakamoto K, Kita K, Tomoda H, Shiomi K, Omura S
- Journal Title
  
  Tetrahedron
  
  Volume : 67 Pages : 6582-6586
- Data Source
  KAKENHI-PROJECT-23590484
[Journal Article] Differential Kinetics Activities of Glycerol Kinase among African Trypanosome Species: Phylogenetic and Therapeitic Implications.2011
- Author(s)
  Ohashi-Suzuki, M., Yabu, Y., Ohshima, S., Nakamura, K., Kido, Y., Sakamoto, K., Kita, K., Ohta, N., Suzuki, T.
- Journal Title
  
  Journal of Veterinary Medical Science
  
  Volume : 73 Pages : 615-621
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23590484, KAKENHI-PROJECT-21380186
[Journal Article] Mass spectrometric analysis of the ubiquinol-binding site in cytochrome bd from Escherichia coli2006
- Author(s)
  Matsumoto Y, Murai M, Fujita D, Sakamoto K, Miyoshi H, Yoshida M, Mogi T
- Journal Title
  
  The Journal of Biological Chemistry 281
  
  Pages : 1905-1912
- Data Source
  KAKENHI-PROJECT-16790244
[Journal Article] Identification and characterization of amino acid residues essential for the active site of UDP-N-acetylenolpyruvylglucosamine reductase (MurB) from Staphylococcus aureus2006
- Author(s)
  Nishida S, Kurokawa K, Matsuo M, Sakamoto K, Ueno K, Kita K, Sekimizu K
- Journal Title
  
  The Journal of Biological Chemistry 281
  
  Pages : 1714-1724
- Data Source
  KAKENHI-PROJECT-16790244
[Journal Article] Alternative Oxidase (AOX) Genes of African Trypanosomes : Phylogeny and Evolution of AOX and Plastid Terminal Oxidase Families2005
- Author(s)
  Suzuki T, Hashimoto T, Yabu Y, Majiwa PA, Ohshima S, Suzuki M, Lu S, Hato M, Kido Y, Sakamoto K, Nakamura K, Kita K, Ohta N
- Journal Title
  
  The Journal of Eukaryotic Microbiology 52
  
  Pages : 374-381
- Data Source
  KAKENHI-PROJECT-16790244
[Journal Article] Mutational analysis of the Trypanosoma vivax alternative oxidase : The E(X)_6Y motif is conserved in both mitochondrial alternative oxidase and plastid terminal oxidase and is indispensable for enzyme activity2005
- Author(s)
  Nakamura K, Sakamoto K, Kido Y, Fujimoto Y, Suzuki T, Suzuki M, Yabu Y, Ohta N, Tsuda A, Onuma M, Kita K.
- Journal Title
  
  Biochemical and Biophysical Research Communications 334
  
  Pages : 593-600
- Data Source
  KAKENHI-PROJECT-16790244
[Presentation] Rhodobacter capsulatus由来bdキノール酸化酵素の解析2016
- Author(s)
  坂元君年, 佐々木智子, Fevzi Daldal
- Organizer
  日本生化学会東北支部第82回例会
- Place of Presentation
  弘前大学
- Year and Date
  2016-05-21
- Data Source
  KAKENHI-PROJECT-26460504
[Presentation] ユビキノンおよびロドキノンの機能研究材料としてのプラナリア2016
- Author(s)
  鎌田紗綾, 坂元君年
- Organizer
  第89回日本生化学会大会
- Place of Presentation
  東北大学
- Year and Date
  2016-09-25
- Data Source
  KAKENHI-PROJECT-26460504
[Presentation] アルファプロテオバクテリア綱の細菌が持つコハク酸脱水素酵素の鉄硫黄クラスター近傍アミノ酸変異による活性制御の解析2016
- Author(s)
  前田晴香、Fevzi Daldal、坂元君年
- Organizer
  日本農芸化学会2016年大会
- Place of Presentation
  札幌コンベンションセンター
- Year and Date
  2016-03-27
- Data Source
  KAKENHI-PROJECT-26460504
[Presentation] Rhodobacter capsulatusとRhodospirillum rubrum間でのキメラ型コハク酸‐ユビキノン還元酵素の作製2013
- Author(s)
  福士実咲・柴谷恵太・Hendri Aldrat・北潔・Fevzi Daldal・坂元君年
- Organizer
  第86回日本生化学会大会
- Place of Presentation
  パシフィコ横浜・横浜
- Data Source
  KAKENHI-PROJECT-23590484
[Presentation] Rhodobacter capsulatusとRhodospirillum rubrum間でのキメラ型コハク酸‐ユビキノン還元酵素の作製2013
- Author(s)
  福士実咲、柴谷恵太、Hendri Aldrat、北潔、Fevzi Daldal、坂元君年
- Organizer
  第86回日本生化学会大会
- Place of Presentation
  パシフィコ横浜
- Data Source
  KAKENHI-PROJECT-23590484
[Presentation] 紅色光合成細菌Rhodobacter capsulatusを用いたコハク酸脱水素酵素複合体の異種生物間発現2012
- Author(s)
  坂元君年・Hendri Aldrat・北潔
- Organizer
  日本農芸化学会2012年度大会
- Place of Presentation
  京都女子大学
- Data Source
  KAKENHI-PROJECT-23590484
[Presentation] コハク酸脱水素酵素複合体の異種生物間発現系の開発2011
- Author(s)
  坂元君年・Hendri Aldrat・北潔
- Organizer
  日本農芸化学会東北支部第146回大会
- Place of Presentation
  山形大学
- Data Source
  KAKENHI-PROJECT-23590484
[Presentation] コハク酸脱水素酵素複合体の異種生物間発現系の開発
- Author(s)
  坂元　君年、Hendri Aldrat、北　潔
- Organizer
  日本農芸化学会東北支部
- Place of Presentation
  山形大学農学部
- Data Source
  KAKENHI-PROJECT-23590484
[Presentation] 紅色光合成細菌Rhodobacter capsulatusを用いたコハク酸脱水素酵素複合体の異種生物間発現
- Author(s)
  坂元　君年、Aldrat Hendri、北　潔
- Organizer
  日本農芸化学会
- Place of Presentation
  京都女子大学
- Data Source
  KAKENHI-PROJECT-23590484
[Presentation] 淡水性プラナリアからのミトコンドリア単離
- Author(s)
  室川聡大、櫻田拓也、坂元君年
- Organizer
  第87回生化学会大会
- Place of Presentation
  国立京都国際会館
- Year and Date
  2014-10-15 – 2014-10-18
- Data Source
  KAKENHI-PROJECT-26460504

1. LEE Wei

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2. KITA Kiyoshi

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3. Inoue Masayuki

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4. TAKEFUMI Kuranaga

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5. HARADA Shigeharu

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6. SONOKI TOMONORI

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7. NARA Takeshi

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8. SHIOMI Kazuro

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9. MASUMA Rokuro

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10. INOUE Noboru

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11. WATANABE Jyunichi

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12. YAMAMOTO Yorihiro

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13. 稲岡健ダニエル

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SAKAMOTO Kimitoshi 坂元 君年

Research Projects

Research Products

Co-Researchers

Reaction mechanism analysis and inhibitor screening of helminthic fumarate quinone reductasePrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Development of the expression system of helminthic mitochondrial quinol-fumarate reductase in bacteria.Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

アフリカトリパノソーマシアン耐性キノール酸化酵素の分子機構Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

アフリカトリパノソーマミトコンドリア末端酸化酵素キノール酸化反応の分子機構Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] The open form inducer approach for structuresed drug design2017

Author(s)

Journal Title

Publisher

Language

Data Source

[Journal Article] Knockdown of the coenzyme Q synthesis gene Smed-dlp1 affects planarian regeneration and tissue homeostasis2015

Author(s)

Journal Title

Data Source

[Journal Article] Enhancement of protocatechuate decarboxylase activity for the effective production of muconate from lignin-related aromatic compounds.2014

Author(s)

Journal Title

Data Source

[Journal Article] Pharmacophore identification of ascofuranone, potent inhibitor of cyanide-insensitive alternative oxidase of Trypanosoma brucei2013

Author(s)

Journal Title

Data Source

[Journal Article] Structure of the trypanosome cyanide-insensitive alternative oxidase2013

Author(s)

Journal Title

Data Source

[Journal Article] Pharmacophore identification of ascofuranone, potent inhibitor of cyanide-insensitive alternative oxidase of Trypanosoma brucei2013

Author(s)

Journal Title

Data Source

[Journal Article] Cloning and characterization of hypoxia-inducible factor-1 subunits from Ascaris suum - a parasitic nematode highly adapted to changes of oxygen conditions during its life cycle2013

Author(s)

Journal Title

Data Source

[Journal Article] Structure of the trypanosome cyanide-insensitive alternative oxidase2013

Author(s)

Journal Title

Data Source

[Journal Article] Crystal structure of mitochondrial quinol-fumarate reductase from the parasitic nematode Ascaris suum2012

Author(s)

Journal Title

Data Source

[Journal Article] Crystal structure of mitochondrial quinol-fumarate reductase from the parasitic nematode Ascaris suum2012

Author(s)

Journal Title

Data Source

[Journal Article] Age-related changes in the activities of respiratory chain complexes and mitochondrial morphology in Drosophila2012

Author(s)

Journal Title

Data Source

[Journal Article] Age-related changes in the activities of respiratory chain complexes and mitochondrial morphology in Drosophila.2011

Author(s)

Journal Title

Data Source

[Journal Article] Uklactones A and B, new NADH-fumarate reductase inhibitors produced by Penicillium sp.FKI-33892011

Author(s)

SAKAMOTO Kimitoshi 坂元君年